Project List
List projects.
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The following relational fields can be expanded:
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begin_planned:gt,gte,lt,ltebegin_effective:gt,gte,lt,lteend_planned:gt,gte,lt,lteend_effective:gt,gte,lt,lte
GET /v1/research/project/?format=api&offset=980&ordering=-begin_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1000&ordering=-begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=960&ordering=-begin_effective", "results": [ { "id": 5528, "title": { "de": "HDAC Inhibition bei Herzinsuffizienz mit erhaltener Ejektionsfraktion", "en": "HDAC Inhibition in Heart Failure with Preserved Ejection Fraction" }, "short": "Startförderung 2018", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-01-01T01:00:00+01:00", "begin_effective": "2018-11-01T01:00:00+01:00", "end_planned": "2021-12-21T01:00:00+01:00", "end_effective": "2021-12-21T01:00:00+01:00", "assignment": "2018-10-23T16:24:44+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 72301, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5528-72301-10", "5528-75758-12" ] }, { "id": 5550, "title": { "de": "Humanisierte Xenotransplantationsmodelle zur Optimierung der Therapie von akuter myeloischer Leukämie. ", "en": "Humanized xenotransplantation models of acute myeloid leukemia to predict patient outcome and direct therapy." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-11-01T01:00:00+01:00", "begin_effective": "2018-11-01T01:00:00+01:00", "end_planned": "2020-10-31T01:00:00+01:00", "end_effective": "2020-10-31T01:00:00+01:00", "assignment": "2018-11-15T14:47:34+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 50747, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1375 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5550-50747-10" ] }, { "id": 5961, "title": { "de": "CAMed - Clinical Additive Manufacturing for Medical Applications", "en": "CAMed - Clinical Additive Manufacturing for Medical Applications" }, "short": "CAMED", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-07-01T02:00:00+02:00", "begin_effective": "2018-11-01T01:00:00+01:00", "end_planned": "2022-06-30T02:00:00+02:00", "end_effective": "2023-10-31T01:00:00+01:00", "assignment": "2019-11-19T16:21:54+01:00", "program": 94, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 2, "manager": 50785, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5961-50785-10" ] }, { "id": 6055, "title": { "de": "COST: Internationales Netzwerk für translationale Forschung an perinatalen Derivaten für therapeutische Applikationen", "en": "COST: International Network for Translating Research on Perinatal Derivatives into Therapeutic Approaches" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-16T02:00:00+02:00", "begin_effective": "2018-10-16T02:00:00+02:00", "end_planned": "2022-10-15T02:00:00+02:00", "end_effective": "2022-10-15T02:00:00+02:00", "assignment": "2020-02-12T16:36:06+01:00", "program": 22, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 51718, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6055-51718-10" ] }, { "id": 5499, "title": { "de": " Promoting patient safety by a novel combination of imaging technologies for biodegradable magnesium implants", "en": " Promoting patient safety by a novel combination of imaging technologies for biodegradable magnesium implants" }, "short": "MgSafe", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-07-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-06-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-27T10:12:59+02:00", "program": 109, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 2, "manager": 50785, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "811226", "ethics_committee": null, "edudract_number": null, "persons": [ "5499-50785-10", "5499-96335-12", "5499-98087-12" ] }, { "id": 5481, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Inflammatory Disorders in Pregnancy" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:19:32+02:00", "program": 114, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 2, "manager": 51756, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5481-51756-10" ] }, { "id": 5517, "title": { "de": "Die Tyrosinkinase Syk: ein möglicher Angriffspunkt bei Atherosklerose", "en": "Die Tyrosinkinase Syk: ein möglicher Angriffspunkt bei Atherosklerose" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2020-01-01T01:00:00+01:00", "end_effective": "2021-12-31T01:00:00+01:00", "assignment": "2018-10-12T12:35:12+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 100805, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 35 ], "funder_projectcode": "ZI 743/8-1", "ethics_committee": null, "edudract_number": null, "persons": [ "5517-91750-12", "5517-99418-12", "5517-100805-10", "5517-101037-12", "5517-102715-12" ] }, { "id": 5482, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Inflammatory Disorders in Pregnancy" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:32:06+02:00", "program": 114, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 53232, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5482-53232-10" ] }, { "id": 5370, "title": { "de": "LipoLUNG: Adipose Triglyzerid Lipase bei Lungenkrebs", "en": "LipoLUNG: Molecular and metabolic roles of Adipocyte Triglyceride Lipase in lung cancer" }, "short": "LipoLUNG", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2021-12-31T01:00:00+01:00", "end_effective": "2023-09-30T02:00:00+02:00", "assignment": "2018-05-23T11:31:07+02:00", "program": 72, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 51691, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P30968", "ethics_committee": null, "edudract_number": null, "persons": [ "5370-50903-12", "5370-57409-12", "5370-51691-10" ] }, { "id": 5218, "title": { "de": "15d-PGJ2: ein möglicher Therapieansatz gegen Osteosarkom?", "en": "15-deoxy-Δ12,14-PGJ2 (15d-PGJ2): a plausible therapeutic agent against osteosarcoma?" }, "short": "15d-PGJ2 und Osteosarkom", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2019-12-31T01:00:00+01:00", "end_effective": "2021-10-31T02:00:00+02:00", "assignment": "2018-01-22T13:01:57+01:00", "program": 79, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 50610, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5218-50610-10", "5218-50990-12", "5218-51705-12", "5218-101018-12" ] }, { "id": 5484, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Inflammatory Disorders in Pregnancy\r\n\r\n" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:33:55+02:00", "program": 114, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 51632, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5484-59816-12", "5484-68413-12", "5484-95608-12", "5484-51632-10", "5484-109041-12", "5484-100803-12" ] }, { "id": 5486, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Inflammatory Disorders in Pregnancy" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:35:48+02:00", "program": 114, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 2, "manager": 90021, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5486-90021-10", "5486-100806-12" ] }, { "id": 5479, "title": { "de": " Inflammatorische Erkrankungen in der Schwangerschaft ", "en": "Inflammatory Disorders in Pregnancy " }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:17:36+02:00", "program": 114, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5527, "title": { "de": "Modellierung des BAP1 Tumor Prädispositions Syndroms unter Verwendung von iPSC generierten Melanozyten zur Untersuchung der frühen genetischen und epigenetischen Stufen der Melanomentstehung ", "en": "Modelling the BAP1 Tumor predisposition syndrome using iPSC-derived melanocytes to investigate the early genetic and epigenetic steps of melanoma development" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2020-10-01T02:00:00+02:00", "end_effective": "2020-09-30T02:00:00+02:00", "assignment": "2018-10-23T16:24:21+02:00", "program": null, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5518, "title": { "de": "Extrazelluläres ATP und purinerge Rezeptoren in der Atherosklerose", "en": "Extrazelluläres ATP und purinerge Rezeptoren in der Atherosklerose" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2020-01-01T01:00:00+01:00", "end_effective": "2021-12-31T01:00:00+01:00", "assignment": "2018-10-12T12:35:25+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 100805, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 35 ], "funder_projectcode": "ZI 743/7-1", "ethics_committee": null, "edudract_number": null, "persons": [ "5518-100805-10", "5518-101037-12", "5518-102715-12" ] }, { "id": 5431, "title": { "de": "Koordination des Doktoratsprogramms: Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Coordination of the Doctoral Program: Inflammatory Disorders in Pregnancy " }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2021-12-31T01:00:00+01:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-26T15:31:56+02:00", "program": 114, "subprogram": "doc.funds", "organization": 14038, "category": 10, "type": 10, "partner_function": 3, "manager": 50442, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5431-50442-10", "5431-56938-12", "5431-59816-12", "5431-83661-12", "5431-90214-12", "5431-95608-12", "5431-100813-12", "5431-100803-12", "5431-105059-12" ] }, { "id": 5485, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Inflammatory Disorders in Pregnancy" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:34:58+02:00", "program": 114, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 54142, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5485-54142-10" ] }, { "id": 5480, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft.\r\nNuclear Rezeptor - vermittelte Regulation metabolischer und inflammatorischer Mediatoren in fetoplazentaren Endothelzellen", "en": "Inflammatory Disorders in Pregnancy.\r\nNuclear receptors regulating metabolism and inflammatory mediators in fetoplacental endothelial cells" }, "short": "DP-iDP", "url": "https://www.medunigraz.at/phd-inflammatory-disorders-in-pregnancy/", "abstract": { "de": null, "en": "Rising evidence suggests that Gestational diabetes mellitus (GDM) modulates the placental endothelium to an altered metabolic state causing vascular dysfunction and altered fetal programming. GDM is associated with oxidative stress which may contribute to endothelial dysfunction. Oxysterols, generated from cholesterol oxidation either by CYP-450 reductase or by reactive oxygen species (ROS), are endogenous activators of liver-X receptors (LXRs), nuclear transcription factors centrally involved in important biological processes, including lipid/cholesterol and glucose metabolism (1). \r\nLXRs promote high-density lipoprotein (HDL) formation by activating several target genes of reverse cholesterol transport. We earlier reported that LXR target genes (ABCA1, ABCG1 and PLTP) are centrally involved in HDL mediated cholesterol efflux from fetoplacental endothelial cells (HPEC) (2-4). \r\nA current focus of our laboratory is to define the impact of oxysterols and pharmacological activators of LXRs on cholesterol-metabolic and inflammatory functions in the GDM feto-placental vasculature. Unpublished results of our group strongly suggest that the GDM environment modulates cholesterol homeostasis by enhancing cholesterol biosynthesis and cholesterol efflux in fetoplacental endothelial cells while cellular cholesterol homeostasis is largely maintained. Thus, GDM may affect placental cholesterol metabolism via LXR activation due to increased oxysterol levels in cells and/or in the fetal circulation. \r\nWhile HDL itself exerts anti-inflammatory actions on endothelial cells, LXRs are also involved in immune regulatory functions and can reduce inflammation by sumoylation-dependent and -independent mechanisms (1). Upon activation, LXRs can be sumoylated and as a monomer can stabilize repressor complexes present on the promoter sequence of proinflammatory pathways such as activator protein 1 (AP-1) and nuclear factor kB (NF-kB), thereby preventing the expression of proinflammatory factors. In brain endothelial cells, LXR activation by oxysterols or synthetic agonist TO901317 significantly reduced expression of inflammatory genes COX-II and TNF along with modulating cellular cholesterol metabolism (5). We hypothesize that endogenous and/or pharmacologic activation of LXRs may improve fetoplacental endothelial function in conditions of GDM and other pregnancy complications related to metabolic diseases.\r\n\r\nReferences:\r\n1.\tGuillemot-Legris O, Mutemberezi V, Muccioli GG. Oxysterols in Metabolic Syndrome: From Bystander Molecules to Bioactive Lipids. Trends Mol Med. 2016; 22(7):594-614.\r\n2.\tStefulj J, Panzenboeck U1, Becker T, Hirschmugl B, Schweinzer C, Lang I, Marsche G, Sadjak A, Lang U, Desoye G, and Wadsack C. Human Endothelial Cells of the Placental Barrier Efficiently Deliver Cholesterol to the Fetal Circulation via ABCA1 and ABCG1. Circ Res. 2009; 104:600-608.\r\n4.\tScholler M, Wadsack C, Metso J, Chirackal Manavalan AP, Sreckovic I, Schweinzer C, Hiden U, Jauhiainen M, Desoye G, Panzenboeck U. Phospholipid transfer protein is differentially expressed in human arterial and venous placental endothelial cells and enhances cholesterol efflux to fetal HDL. J Clin Endocrinol Metab. 2012; 97:2466-74.\r\n5.\tScholler M, Wadsack C, Lang I, Etschmaier K, Schweinzer C, Marsche G, Dieber-Rotheneder M, Desoye G, Panzenboeck U. Phospholipid Transfer Protein in the Placental Endothelium Is Affected by Gestational Diabetes Mellitus. J Clin Endocrinol Metab. 2012; 97:437-45.\r\n7.\tSchweinzer C, Kober A, Lang I, Etschmaier K, Scholler M, Kresse A, Sattler W, Panzenboeck U. Processing of Endogenous AβPP in Blood-Brain Barrier Endothelial Cells is Modulated by Liver-X Receptor Agonists and Altered Cellular Cholesterol Homeostasis. J Alzheimers Dis. 2011; 27(2):341-360.\r\n" }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:18:44+02:00", "program": 114, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 50442, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5480-50442-10", "5480-61645-12" ] }, { "id": 5487, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Inflammatory Disorders in Pregnancy" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:36:55+02:00", "program": 114, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51904, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5487-51904-10" ] }, { "id": 5428, "title": { "de": "Endo/lysosomale Beweglichkeit & Funktion in Leber -Physiologie und -Pathology", "en": "Endo/lysosome motility & function in liver physiology and liver pathology" }, "short": "“Wissenschaftspreis der ÖGGH”", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2020-04-01T02:00:00+02:00", "end_effective": "2022-03-31T02:00:00+02:00", "assignment": "2018-08-03T17:24:25+02:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 57596, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 203 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5428-57596-10", "5428-113189-12", "5428-123430-12" ] } ] }