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GET /v1/research/project/?format=api&offset=980&ordering=-begin_effective
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1000&ordering=-begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=960&ordering=-begin_effective", "results": [ { "id": 5515, "title": { "de": "COST: Krebs-Nanomedizin - vom Labor zum Patienten", "en": "COST: Cancer-Nanomedicine - from the bench to the bedside" }, "short": "NANO2CLINIC", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-09-29T02:00:00+02:00", "begin_effective": "2018-09-29T02:00:00+02:00", "end_planned": "2022-09-28T02:00:00+02:00", "end_effective": "2022-09-28T02:00:00+02:00", "assignment": "2018-10-11T11:51:19+02:00", "program": 22, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 2, "manager": 83066, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5515-83066-10" ] }, { "id": 5467, "title": { "de": "Modifikation des Mikrobioms zur Verbesserung von Metabolismus, Darmbarriere und Entzündung bei kindlichem Neuroblastom", "en": "Modification of the intestinal microbiome to improve metabolism, gut barrier function and inflammation in neuroblastoma" }, "short": "Mikrobiom-Tumor", "url": null, "abstract": { "de": "HINTERGRUND: Im Rahmen von malignen Tumorerkrankungen kann es zu einem katabolen Zustandsbild mit Verlust von Fett- und Muskelgewebe kommen. Dieses geht mit erheblicher Morbidität und Mortalität einher und wird als Kachexie bezeichnet. Obwohl die volle Ausprägung selten ist, wird bei bis zu 50% der pädiatrischen Malignome eine Unterernährung diagnostiziert. Neben dem Tumor selbst können auch Nebenwirkungen der Chemotherapie schwerwiegende Probleme bereiten. So wird in bis zu 60% dieser Kinder eine Mukositis des Gastrointestinaltraktes beobachtet, die sich klinisch durch Übelkeit, Erbrechen, Durchfall oder Obstipation, Schmerzen und – im schlimmsten Fall – lebensbedrohlichen Entzündungsreaktionen kennzeichnet. Im Alltag kann das eine Reduktion der Chemotherapie oder einen Ausfall eines Zyklus mit reduzierter Effektivität der Chemotherapie erfordern. Bisher ist die Therapie der Mukositis rein symptomatisch. Rezente Untersuchungen des Antragsstellers haben im Mikrobiom von Mäusen mit Neuroblastom (einem malignen Tumor des Kindesalters) einen signifikanten Abfall der Lactobacilli beobachtet, der mit einem pro-inflammatorischen Zustandsbild, Kachexie und gesteigerter Darmpermeabilität einherging. In diesem Modell hat auch die Chemotherapie alleine eine Dysbiose mit Abfall der Lactobacilli ausgelöst, was ursächlich mit der Entstehung einer Mukositis in Verbindung stehen könnte. Insgesamt scheint das intestinale Mikrobiom einen erheblichen Bestandteil in der Entstehung von Kachexie und chemotherapie-induzierter Mukositis zu haben.\r\nZIEL: Ziel dieses Projektes ist es zu untersuchen, ob eine Manipulation des Mikrobioms mittels Präbiotika, Probiotika oder Bakteriozinen einen positiven Einfluss auf Entzündungsreaktion, Darmwandbarriere und Metabolismus bei Neuroblastomen hat. Zusätzlich soll beurteilt werden, ob die im Tiermodell beobachten mikrobiellen Veränderungen auch bei Kindern mit Neuroblastom beobachtet werden können.\r\nMETHODEN: Im tierexperimentellen Teil wird das bereits etablierte Neuroblastommodell verwendet um bei Mäusen eine Kachexie auszulösen. Zusätzlich wird einem Teil der Mäuse eine Chemotherapie verabreicht. Danach wird im ersten Arbeitspaket der Einfluss von Omni-Logic® Apfelpektin und Omni-Biotic® AAD auf diese Mäuse untersucht. Der Hauptfokus liegt dabei auf der Beurteilung des fäkalen Mikrobioms, des bakteriellen Metabolismus, der Darmwandbarriere, Mukositis, des Entzündungssystemes und des Metabolismus. In einem weiteren Arbeitspaket werden dann speziell auf die beobachteten Veränderungen des Mikrobioms ausgerichtete Bakteriozine und antimikrobielle Metabolite hergestellt, für die in-vivo Anwendung angepasst, und im gleichen Tiermodell angewendet. Im grundlagenwissenschaftlichen humanen Teil des Projektes wird untersucht, ob zwischen Kindern mit Neuroblastom und gesunden Kontrollen ein Unterschiede im Mikrobiom und im Profil der volatilen Gase in Stuhl und Atemluft besteht. Zusätzlich wird in diesem Paket durch serielle Messungen Fokus auf mögliche Veränderungen des intestinalen Mikrobioms im Verlauf der Chemotherapie gelegt.\r\nINNOVATIONSGEHALT: Um die Forschungsschwerpunkte dieses Projektes zu beurteilen, kommen hochmoderne Verfahren zur Anwendung. Insbesondere die Untersuchung der volatilen Gase in Stuhl und Atemluft ist auf diesem Gebiet neu und gibt wichtige, nicht-invasive Einblicke in die mikrobielle Besiedelung und damit indirekt auf Metabolismus und Entzündungsreaktion der PatientInnen. Die in diesem Projekt untersuchten Prä- und Probiotika sind bereits am Markt erhältlich. Sollte sich durch ihren Einsatz eine Reduktion der Tumor- oder Chemotherapie-bedingten Störungen des Entzündungssystems, der Darmwandbarriere und des Metabolismus ergeben, könnten diese Produkte zukünftig supportiv in der Anti-Tumortherapie angewendet werden und zur Reduktion der Morbidität beitragen. Der Therapieansatz mit Bakteriozinen ist wissenschaftliches Neuland. \r\n", "en": "BACKGROUND: Malignant tumors may lead to a catabolic state with loss of muscle and adipose tissue. The full picture of catabolism is termed cachexia and is associated with significant morbidity and mortality of cancer patients. Although the full picture is rarely observed up to 50% of children with cancer suffer from significant malnourishment. Additionally to tumor-induced catabolism, side-effects of chemotherapy may be problematic for the patients. In this regard up to 60% of children suffer from gastrointestinal mucositis presenting with nausea, vomiting, diarrhea or constipation and abdominal pain. In the worst case, mucositis may lead to bacterial translocation with life-threatening inflammatory response. Clinically this may require a reduction of the dosage or the number of chemotherapy cycles resulting in reduced effectivity. Up to now the therapy of mucositis is only symptomatic. Recent research of the applicant has shown a significant reduction of Lactobacilli in mice with neuroblastoma (a malignant childhood tumor). The dysbiosis was associated with catabolism, increased gut permeability and inflammation. Astonishingly, chemotherapy alone also lead to a significant reduction of Lactobacilli compared to sham mice, which may be linked to the development of mucositis clinically. Overall, the intestinal microbiome seems to play an essential role in the development of tumor-associated catabolism and chemotherapy-induced mucositis.\r\nAIM: The aim of this project is to determine if manipulation of the intestinal microbiome with prebiotics, probiotics and bacteriocins (also referred to as lantibiotics) exerts beneficial effects on inflammation, gut permeability and metabolism in a murine model of neuroblastoma. Additionally, a human work package should determine if the changes in the intestinal microbiome observed in mice can also be seen in children with neuroblastoma.\r\nMETHODS: An established neuroblastoma model will be used to cause cachexia in mice. Additionally, a group of animals will receive chemotherapy. One work package will analyze the effect of Omni-Logic® Apfelpektin (a prebiotic containing pectin oligosaccharides) and Omni-Biotic® AAD (a probiotic) on these mice. The main focus will be on the intestinal microbiome, bacterial metabolism , gut permeability , mucositis , inflammation and metabolism. Additionally, data gained on microbial alterations by tumor and chemotherapy will be used to select specific bacteriocins and bacterial metabolites to influence the microbiome. These substances will be prepared for in vivo testing and applied to the same animal model. A basic science human work package will address the question if there are differences in the intestinal microbiome and the volatile organic compound profile between children with neuroblastoma and healthy controls. Furthermore, serial investigations in children with neuroblastoma will assess whether of not these patients show alterations of the intestinal microbiome under chemotherapy.\r\nINNOVATIONS: In this project cutting edge technology will be used to gain information about the main research topics. Especially the examination of volatile organic compounds in relation to the other tests is novel in this research field and provides non-invasive information about bacterial metabolism and indirectly on the patients’ inflammatory system and metabolism. The pre- and probiotics tested in this project are available on the market. If they lead to a reduction of tumor- or chemotherapy-induced disturbances of inflammatory system, gut barrier or metabolism in this project they may be easily used as supportive measures in the anti-cancer therapy of the future. The use of bacteriocins has presently not been tested in this context. If these substances would prove effective then this project would be a first important milestone towards human application of bacteriocins.\r\n" }, "begin_planned": "2018-08-01T02:00:00+02:00", "begin_effective": "2018-09-01T02:00:00+02:00", "end_planned": "2021-07-31T02:00:00+02:00", "end_effective": "2022-06-30T02:00:00+02:00", "assignment": "2018-09-03T17:23:35+02:00", "program": 60, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 54087, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "867991", "ethics_committee": null, "edudract_number": null, "persons": [ "5467-50778-12", "5467-50881-12", "5467-54087-10", "5467-73734-12", "5467-90375-12", "5467-100457-12", "5467-102412-12" ] }, { "id": 5471, "title": { "de": "Klinische Anwendbarkeit ex vivo generierter Erythrozyten mit Fokus auf biomechanische Eigenschaften", "en": "Clinical translation of ex vivo cultured erythrocytes – biomechanical properties of manufactured red blood cells\r\n\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-09-01T02:00:00+02:00", "begin_effective": "2018-09-01T02:00:00+02:00", "end_planned": "2020-08-31T02:00:00+02:00", "end_effective": "2022-10-31T01:00:00+01:00", "assignment": "2018-09-11T18:08:07+02:00", "program": null, "subprogram": null, "organization": 14058, "category": 10, "type": 10, "partner_function": 4, "manager": 51164, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5471-51164-10" ] }, { "id": 5459, "title": { "de": "Führt die Zwerchfellhernie zu Unterschieden im pulmonalen Mikrobiom und Atemgasprofil im Vergleich zu gesunden Kindern?\r\n\r\n", "en": "Does congenital diaphragmatic hernia lead to alterations in pulmonary microbiome and exhaled volatile organic compounds compared to healthy children?" }, "short": "CDH VOC Study", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-09-01T02:00:00+02:00", "end_planned": "2019-10-31T01:00:00+01:00", "end_effective": "2019-10-31T01:00:00+01:00", "assignment": "2018-08-27T14:52:47+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5459-50778-12", "5459-54087-12" ] }, { "id": 5424, "title": { "de": "Modeling subclonal heterogeneity, chemotherapy-resistance and relapse of acute myeloid leukemia in a novel refined humanized xenotransplantation model.", "en": "Ein neues humanisiertes Xenotransplantationsmodell zur Analyse von subclonaler Heterogenität, Chemotherapie-Resistenz und Relaps in der akuten myeloischen Leukämie. " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-09-01T02:00:00+02:00", "begin_effective": "2018-09-01T02:00:00+02:00", "end_planned": "2020-08-30T02:00:00+02:00", "end_effective": "2021-12-31T01:00:00+01:00", "assignment": "2018-07-25T13:01:06+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 50747, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 204 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5424-50747-10" ] }, { "id": 5419, "title": { "de": "Potential der MRT 4D-Flussbildgebung zur Charakterisierung der diastolischen Herzfunktion", "en": "Potential role of MR 4D-Flow imaging for the characterization of diastology" }, "short": "CMR2018", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-08-01T02:00:00+02:00", "begin_effective": "2018-08-01T02:00:00+02:00", "end_planned": "2021-07-31T02:00:00+02:00", "end_effective": "2022-07-31T02:00:00+02:00", "assignment": "2018-07-17T13:49:17+02:00", "program": null, "subprogram": null, "organization": 14104, "category": 10, "type": 10, "partner_function": 4, "manager": 82111, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": "17934", "ethics_committee": null, "edudract_number": null, "persons": [ "5419-82111-10" ] }, { "id": 5425, "title": { "de": "Charakterisierung von CD20+ T-Lymphozyten bei Patienten mit Sklerodermie (SSc) und Sjögren Syndrom (SS)", "en": "Characterization of CD20 + T-lymphocytes in Systemic Sclerosis (SSc) and Sjögren Syndrom (SS)" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-08-01T02:00:00+02:00", "begin_effective": "2018-08-01T02:00:00+02:00", "end_planned": "2019-08-01T02:00:00+02:00", "end_effective": "2023-12-31T01:00:00+01:00", "assignment": "2018-07-25T13:09:54+02:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 4, "manager": 96624, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 87 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5425-96624-10" ] }, { "id": 5422, "title": { "de": "PROVIT CLOCK (Stadt Graz Projekt)", "en": "PROVIT CLOCK (Stadt Graz Projekt)" }, "short": "PROVIT CLOCK", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-07-18T02:00:00+02:00", "begin_effective": "2018-08-01T02:00:00+02:00", "end_planned": "2019-07-19T02:00:00+02:00", "end_effective": "2022-12-31T01:00:00+01:00", "assignment": "2018-07-24T15:55:55+02:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": 79771, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": 8, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5422-79771-10" ] }, { "id": 5421, "title": { "de": "Etablierung neuer Gallengangskarzinom-Zelllinien", "en": "Establishment of New Cholangiocarcinoma Cell Lines" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-08-01T02:00:00+02:00", "begin_effective": "2018-08-01T02:00:00+02:00", "end_planned": "2019-08-01T02:00:00+02:00", "end_effective": "2019-12-31T01:00:00+01:00", "assignment": "2018-07-23T15:55:57+02:00", "program": null, "subprogram": null, "organization": 27477, "category": 10, "type": 10, "partner_function": 4, "manager": 50826, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5421-50826-10" ] }, { "id": 5382, "title": { "de": "Die angiogenetische Potenz von Melanozyten", "en": "Melanocytes and angiogenesis" }, "short": "Angiogenese", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-07-01T02:00:00+02:00", "begin_effective": "2018-07-01T02:00:00+02:00", "end_planned": "2020-07-01T02:00:00+02:00", "end_effective": "2022-12-31T01:00:00+01:00", "assignment": "2018-06-07T10:57:35+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": 73157, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 938 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5382-73157-10" ] }, { "id": 5420, "title": { "de": "Pilotstudie zur Evaluierung der Korrelation von Tumor mutational Burden mit der Überlebensdauer von Krebspatienten", "en": "Pilot study for the evaluation of the correlation of tumor mutational burden and overall survival" }, "short": "TMB", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-07-01T02:00:00+02:00", "begin_effective": "2018-07-01T02:00:00+02:00", "end_planned": "2019-07-31T02:00:00+02:00", "end_effective": "2019-07-31T02:00:00+02:00", "assignment": "2018-07-20T15:27:52+02:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 57386, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-32", "ethics_committee": null, "edudract_number": null, "persons": [ "5420-57386-10" ] }, { "id": 5401, "title": { "de": "Virtuelle und Augmentierte Realität zur 3D Rekonstruktion", "en": "Virtual and Augmented Reality Module for 3D Reconstruction" }, "short": "enFaced", "url": "https://www.tugraz.at/index.php?id=26448", "abstract": { "de": null, "en": "This interdisciplinary research project between computer science and medicine targets the development of a comprehensive image-guided tool for head and neck surgery with the main focus on mandibular and mid-facial fractures. The tool supports the physicians in all treatment stages (diagnosis, planning, intervention and monitoring) and can also be used during clinical traineeship. A key point is the development of an algorithm for the semi-automatic and automatic segmentation of bone structures and soft tissue in CT and MRI acquisitions. A segmentation enables a three-dimensional localization, quantification and visualization of biological structures in a very short time. Based on the radiological images from the clinical routine, treatment diagnosis can be visualized, and surgical planning processes or alternative surgery options can be simulated. In addition, the postoperative simulation results can be presented preoperatively in a photo-realistic manner. In particular, this will be applied in the reposition of bony structures, the reconstruction of facial defects and the removal of tumors in complex anatomical areas. Moreover, we plan the development of patient-individual three-dimensional implants, which will 3D printed in-house for comparison with the external manufactured ones and for clinical usage. Furthermore, the medical personnel can be supported in real-time during surgery by an interactive navigation, where Augmented Reality integrates computer-generated objects into the operation field. The application reduces surgical complications and ensures a successful treatment result by pre- and intraoperative simulations. Hence, the number of necessary corrective surgeries and the operation time needed can be reduced, and a higher patient survival rate can be achieved. In addition, the combination with Virtual Reality glasses allows the virtual training of operations during medical education. The objective of the project is the establishment of an open source tool as basis for further research and developments for the participating universities. Currently, comparable tools are protected by strict licensing conditions and not accessible without restrictions for academic research. Existing software for clinical practice is not functionally stable enough and has too high error rates. Additionally, the usage imposes high financial costs, which makes a widespread application not possible. Finally, Augmented Reality in the clinical routine is an important topic for current surgical research and cannot be ignored by modern medical universities.\r\n\r\n" }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2018-07-01T02:00:00+02:00", "end_planned": "2021-12-31T01:00:00+01:00", "end_effective": "2021-09-30T02:00:00+02:00", "assignment": "2018-06-21T10:10:08+02:00", "program": 108, "subprogram": null, "organization": 14112, "category": 10, "type": 10, "partner_function": 4, "manager": 76910, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI 678-B31", "ethics_committee": null, "edudract_number": null, "persons": [ "5401-76910-10" ] }, { "id": 5491, "title": { "de": "Zirkulierende Tumor DNA bei Patienten mit Prostatakarzinom: Analysen der Androgen Rezeptor Achse und DNA Reparaturgene aus Plasma-DNA", "en": "ctDNA in prostate cancer patients: Analyses of androgene receptors axis and DNA damage repair genes from plasma DNA " }, "short": "Liquid Biopsy", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-06-01T02:00:00+02:00", "begin_effective": "2018-06-01T02:00:00+02:00", "end_planned": "2021-05-31T02:00:00+02:00", "end_effective": "2021-12-31T01:00:00+01:00", "assignment": "2018-09-20T15:34:55+02:00", "program": 108, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 4, "manager": 57423, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI 710", "ethics_committee": null, "edudract_number": null, "persons": [ "5491-57423-10" ] }, { "id": 5619, "title": { "de": "Breast-Q", "en": "Breast-Q" }, "short": "Breast-Q - FFG Talente", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-07-02T02:00:00+02:00", "begin_effective": "2018-06-01T02:00:00+02:00", "end_planned": "2018-07-31T02:00:00+02:00", "end_effective": "2018-09-30T02:00:00+02:00", "assignment": "2019-01-21T09:54:31+01:00", "program": null, "subprogram": null, "organization": 14076, "category": 10, "type": 10, "partner_function": 4, "manager": 81670, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 3023 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5619-81670-10" ] }, { "id": 5212, "title": { "de": "Neuronale Netzwerke in Lipase-defizienten Mäusen ", "en": "Neuronal circuits in lipase deficient mouse models" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-05-01T02:00:00+02:00", "begin_effective": "2018-05-01T02:00:00+02:00", "end_planned": "2018-07-31T02:00:00+02:00", "end_effective": "2018-07-31T02:00:00+02:00", "assignment": "2018-01-18T13:27:32+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 95211, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 431 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5212-95211-10" ] }, { "id": 5359, "title": { "de": "Humanmilch Oligosaccharide im ersten Schwangerschaftstrimester ", "en": "First Trimester Human Milk Oligosaccharides" }, "short": "FirstHMOs", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-04-01T02:00:00+02:00", "begin_effective": "2018-05-01T02:00:00+02:00", "end_planned": "2018-09-30T02:00:00+02:00", "end_effective": "2019-09-13T02:00:00+02:00", "assignment": "2018-05-03T12:13:57+02:00", "program": null, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 88993, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": 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downregulation\r\nin aggressive lymphomas" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-05-01T02:00:00+02:00", "begin_effective": "2018-05-01T02:00:00+02:00", "end_planned": "2020-04-30T02:00:00+02:00", "end_effective": "2020-04-30T02:00:00+02:00", "assignment": "2018-05-16T10:36:08+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 59183, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1375 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5364-100134-12", "5364-59183-10", "5364-65239-12", "5364-51930-12", "5364-107832-12" ] } ] }