Project List
List projects.
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The following relational fields can be expanded:
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GET /v1/research/project/?format=api
{ "count": 2194, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=20", "previous": null, "results": [ { "id": 2965, "title": { "de": "DK \"Molecular Fundamentals of Inflammation\" - Koordination (1. Förderperiode)", "en": "DK \"Molecular Fundamentals of Inflammation\" - Koordination (1. funding periode)" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-10-01T02:00:00+02:00", "begin_effective": "2012-03-01T01:00:00+01:00", "end_planned": "2016-09-30T02:00:00+02:00", "end_effective": "2016-02-29T01:00:00+01:00", "assignment": "2012-09-06T12:38:45+02:00", "program": 66, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 1, "manager": 51756, "contact": 51756, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1241", "ethics_committee": null, "edudract_number": null, "persons": [ "2965-74174-12", "2965-86124-12", "2965-86588-12", "2965-87133-12", "2965-51756-10" ] }, { "id": 2618, "title": { "de": "Wirkung des neuen Lipidsenkers Niacin/Laropiprant (Tredaptive®) auf Funktion humaner Blutplättchen", "en": "Effect of the novel lipid-lowering therapy niacin plus laropiprant (Tredaptive®) on platelet function: Benefit or hazard?" }, "short": "LIPIDSENKER NIACIN/LAROPIPRANT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2013-09-30T02:00:00+02:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2011-10-19T13:21:31+02:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 51756, "contact": 51756, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2618-51756-10" ] }, { "id": 2342, "title": { "de": "Quantifizierung der orthostatischen Kapazität", "en": "Orthocap - Use of galanin and adrenomedullin responses to quantify orthostatic capacity" }, "short": "Orthocap", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-07-31T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2010-11-22T12:56:50+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 51683, "contact": 51683, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2342-51683-10" ] }, { "id": 2323, "title": { "de": "Computermodelle strukturell degenerativer Herzerkrankungen", "en": "Computermodelle strukturell degenerativer Herzerkrankungen" }, "short": "Computermodelle Herzerkrankung", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-11-01T01:00:00+01:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2010-10-31T02:00:00+02:00", "end_effective": "2010-07-31T02:00:00+02:00", "assignment": "2010-10-05T11:55:03+02:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 1, "manager": 51502, "contact": 51502, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2323-51502-10" ] }, { "id": 7055, "title": { "de": "Lösung des offenen Rätsels von TRPC3 durch Photopharmakologie", "en": "Resolving the open state enigma of TRPC3 by photopharmacology" }, "short": null, "url": null, "abstract": { "de": "• Wider research context / theoretical framework: TRPC3 is a distinct member of TRPC family. This channel is expressed in excitable and non-excitable cells. By non-selectively conducting cations even at its resting state, TRPC3 promotes cellular processes in both health and disease. However, there are only a few modulators of this channel available. To precisely design new therapeutic ligands, it is of high importance to gain knowledge about TRPC3 protein structure and, consequently, its gating mechanism. Recently, two TRPC3 structures were revealed by cryo electron microscopy (cryo-EM). Nonetheless, neither of them captured open pore architecture. Hence, the open conformations is the critical missing piece of information to solve the TRPC3 gating puzzle. This knowledge is essential for comprehension of the molecular function of TRPC3 and definition of possible ligand binding sites to control this channel is health and, especially, disease.\r\n• Hypotheses / research questions / objectives: Here, we propose to succeed in capturing open pore structures of TRPC3 by stabilizing and synchronizing the channels at a high open probability using photochromic ligands and in addition by preserving their lipid environment during the protein preparation for cryo-EM.\r\n• Approach / methods: We will screen two expression systems for suitability to maintain TRPC3 in open conformation. We will utilize photopharmacological tools for a temporal control over TRPC3 gating during protein extraction and cryo-EM. Structural details obtained from cryo-EM will be followed by structure-guided mutagenesis and evaluated in a multifunctional live cell approach combining Ca2+ imaging and electrophysiology.\r\n• Level of originality / innovation: With our project, we will introduce a novel approach to control protein conformations during cryo-EM by photoswitchable ligands. Our work will unravel TRPC3 open architecture and promote the development of new concepts for therapeutic targeting of these channels.\r\n• Primary researchers involved: The research team will include profound experts in TRPC3 electrophysiology and Ca2+ signaling Dr. Oleksandra Tiapko and Dr. Klaus Groschner (Medical University of Graz, Austria), experts in membrane lipids Dr. Anita Emmerstorfer-Augustin (Graz University of Technology) and in structural biology and electron microscopy Dr. Christine Ziegler (University of Regensburg).", "en": "• Wider research context / theoretical framework: TRPC3 is a distinct member of TRPC family. This channel is expressed in excitable and non-excitable cells. By non-selectively conducting cations even at its resting state, TRPC3 promotes cellular processes in both health and disease. However, there are only a few modulators of this channel available. To precisely design new therapeutic ligands, it is of high importance to gain knowledge about TRPC3 protein structure and, consequently, its gating mechanism. Recently, two TRPC3 structures were revealed by cryo electron microscopy (cryo-EM). Nonetheless, neither of them captured open pore architecture. Hence, the open conformations is the critical missing piece of information to solve the TRPC3 gating puzzle. This knowledge is essential for comprehension of the molecular function of TRPC3 and definition of possible ligand binding sites to control this channel is health and, especially, disease.\r\n• Hypotheses / research questions / objectives: Here, we propose to succeed in capturing open pore structures of TRPC3 by stabilizing and synchronizing the channels at a high open probability using photochromic ligands and in addition by preserving their lipid environment during the protein preparation for cryo-EM.\r\n• Approach / methods: We will screen two expression systems for suitability to maintain TRPC3 in open conformation. We will utilize photopharmacological tools for a temporal control over TRPC3 gating during protein extraction and cryo-EM. Structural details obtained from cryo-EM will be followed by structure-guided mutagenesis and evaluated in a multifunctional live cell approach combining Ca2+ imaging and electrophysiology.\r\n• Level of originality / innovation: With our project, we will introduce a novel approach to control protein conformations during cryo-EM by photoswitchable ligands. Our work will unravel TRPC3 open architecture and promote the development of new concepts for therapeutic targeting of these channels.\r\n• Primary researchers involved: The research team will include profound experts in TRPC3 electrophysiology and Ca2+ signaling Dr. Oleksandra Tiapko and Dr. Klaus Groschner (Medical University of Graz, Austria), experts in membrane lipids Dr. Anita Emmerstorfer-Augustin (Graz University of Technology) and in structural biology and electron microscopy Dr. Christine Ziegler (University of Regensburg)." }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-10-31T01:00:00+01:00", "assignment": "2022-06-13T15:55:42+02:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 90337, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": " P 35291", "ethics_committee": null, "edudract_number": null, "persons": [ "7055-90337-10", "7055-116421-12" ] }, { "id": 2531, "title": { "de": "Lipasen und lipotoxische Lipid in Makrophagen: Rolle in der Atherogenese", "en": "Lipases and lipotoxic lipids in macrophages: Role in atherogenesis" }, "short": "LIPASES AND LIPOTOXIC LIPIDS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-04-01T02:00:00+02:00", "begin_effective": "2011-04-01T02:00:00+02:00", "end_planned": "2014-03-31T02:00:00+02:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2011-07-14T17:09:54+02:00", "program": 67, "subprogram": "P04", "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51904, "contact": 51904, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "F30", "ethics_committee": null, "edudract_number": null, "persons": [ "2531-51904-10" ] }, { "id": 2872, "title": { "de": "Chordom - Charakterisierung der MUG-Chor1 Zelllinie", "en": "Chordoma - Characterizing MUG-Chor1 cell line" }, "short": "Chordoma", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-01T02:00:00+02:00", "begin_effective": "2012-04-01T02:00:00+02:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2012-05-24T12:00:53+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 54171, "contact": 54171, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2872-54171-10" ] }, { "id": 2481, "title": { "de": "Lese-Rechtschreibstörung (LRS): Risikofaktoren, Früherkennung und Förderung", "en": "Lese-Rechtschreibstörung (LRS): Risikofaktoren, Früherkennung und Förderung" }, "short": "LRS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-01T02:00:00+02:00", "begin_effective": "2011-06-01T02:00:00+02:00", "end_planned": "2012-08-31T02:00:00+02:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2011-05-19T11:44:02+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 58883, "contact": 58883, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2481-50173-10", "2481-58883-10", "2481-77049-12" ] }, { "id": 3003, "title": { "de": "An Interdisciplinary View: The Early Phenotype of Fragile-X Syndrome Delineating First Signs of Deviation for Timely Detection.", "en": "An Interdisciplinary View: The Early Phenotype of Fragile-X Syndrome Delineating First Signs of Deviation for Timely Detection." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-01-01T01:00:00+01:00", "end_planned": "2015-12-31T01:00:00+01:00", "end_effective": "2018-01-01T01:00:00+01:00", "assignment": "2012-10-16T16:56:43+02:00", "program": 72, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 58883, "contact": 58883, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P25241", "ethics_committee": null, "edudract_number": null, "persons": [ "3003-58883-10" ] }, { "id": 2257, "title": { "de": "Einfluss unterschiedlicher Lichtspektren am Arbeitsplatz auf Physiologie und circadiane Rhythmik", "en": "Physiological and circadian effects of light in the work-place" }, "short": "Wirkung von Licht am Arbeitsplatz", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-01T02:00:00+02:00", "begin_effective": "2010-08-01T02:00:00+02:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2012-09-30T02:00:00+02:00", "assignment": "2010-07-29T12:08:13+02:00", "program": 79, "subprogram": "Interdisziplinäre Humanmedizin", "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 51671, "contact": 51671, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": "13891", "ethics_committee": null, "edudract_number": null, "persons": [ "2257-51671-10" ] }, { "id": 2896, "title": { "de": "Transport von mütterlichem Serotonin über die humane Plazenta: Studien an primären Endothezellen der menschlichen Plazenta", "en": "Transport of Maternal Serotonin across Human Placenta: studies on primary endothelial cells of human placental barrier" }, "short": "Transport of Maternal Serotonin", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-01-01T01:00:00+01:00", "begin_effective": "2012-01-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2012-06-21T11:08:07+02:00", "program": 92, "subprogram": "WTZ-Kroatien", "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2896-50442-12", "2896-51632-12" ] }, { "id": 2504, "title": { "de": "Subtyp-spezifische, nicht kompetitive metabotrope Glutamatrezeptor-1 Antoagonisten als neuer alternativer Therapieansatz bei neuroendokrinen Tumoren", "en": "Subtype-specific, non competitive metabotropic glutamatereceptor-1 antagonists as novel alternative therapeutic option for neuroendocrine tumors" }, "short": "glutamate-receptor-1 antagonists", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2012-01-31T01:00:00+01:00", "assignment": "2011-06-21T11:36:12+02:00", "program": null, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2521, "title": { "de": "NEUE WIRKSTOFFE ZUR THERAPIE GASTROENTEROPANKREATISCHER TUMOREN (CARCINOIDS)", "en": "NOVEL AGENTS FOR THERAPY OF GASTROENTEROPANCREATIC TUMORS (CARCINOIDS)" }, "short": "CARCINOID THERAPY", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2011-07-06T10:24:22+02:00", "program": null, "subprogram": "Stadt Graz Kulturamt - Wissenschaft", "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2616, "title": { "de": "Subtyp-spezifische, nicht kompetitive, metabotrope Glutamat Rezeptor-1 (mGluR1) Antagonisten als neuer Weg zur Therapie von neuroendokrinen Tumoren", "en": "Subtype-specific, non-competitive, metabotropic glutamate receptor-1 (mGluR1) antagonists as a new avenue of therapeutic intervention in neuroendocrine tumors" }, "short": "GLUTAMATE RECEPTOR NEUROENDOCRINE TUMORS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2014-06-30T02:00:00+02:00", "end_effective": "2016-06-30T02:00:00+02:00", "assignment": "2011-10-18T16:00:57+02:00", "program": 79, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2616-50379-12" ] }, { "id": 2398, "title": { "de": "SIMNET STYRIA 2009/2010", "en": "SIMNET STYRIA 2009/2010" }, "short": "SIMNET", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-05-18T02:00:00+02:00", "begin_effective": "2009-05-18T02:00:00+02:00", "end_planned": "2011-05-31T02:00:00+02:00", "end_effective": "2011-05-31T02:00:00+02:00", "assignment": "2011-02-07T14:48:55+01:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 2, "manager": 50966, "contact": 50966, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2398-50966-10" ] }, { "id": 2719, "title": { "de": "SFB: Mathematische Optimierung mit Anwendungen in der biomedizinischen Forschung \r\n2. Förderperiode", "en": "SFB: Mathematical Optimization with Applications in Biomedical Sciences" }, "short": "MOBIS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-01T02:00:00+02:00", "begin_effective": "2011-05-01T02:00:00+02:00", "end_planned": "2014-04-30T02:00:00+02:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2012-01-09T14:26:01+01:00", "program": 67, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 50966, "contact": 50966, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "F32", "ethics_committee": null, "edudract_number": null, "persons": [ "2719-50966-10" ] }, { "id": 2547, "title": { "de": "SFB: Myeloperoxidase-vermittelte Lipotoxizität im Zentralnervensystem", "en": "Myeloperoxidase-mediated lipotoxicity in the central nervous system" }, "short": "MYELOPEROXIDASE-MEDIATED LIPOTOXICITY", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-01T02:00:00+02:00", "begin_effective": "2011-05-01T02:00:00+02:00", "end_planned": "2014-05-01T02:00:00+02:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2011-07-28T12:47:37+02:00", "program": 67, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51705, "contact": 51705, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "F30", "ethics_committee": null, "edudract_number": null, "persons": [ "2547-51705-10" ] }, { "id": 2973, "title": { "de": "DK \"Molecular Fundamentals of Inflammation\"", "en": "DK \"Molecular Fundamentals of Inflammation\"" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-10-01T02:00:00+02:00", "end_planned": "2016-02-28T01:00:00+01:00", "end_effective": "2016-09-30T02:00:00+02:00", "assignment": "2012-09-06T13:04:33+02:00", "program": 66, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": 51831, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1241", "ethics_committee": null, "edudract_number": null, "persons": [ "2973-51831-10", "2973-95211-12" ] }, { "id": 2771, "title": { "de": "Cholesterin-25-Hydroxylase beim Glioblastomwachstum", "en": "25-Hydroxycholesterol as transcriptional regulator of the human astrocytoma grade IV (glioblastoma multiforme) tumor microenvironment" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-01-01T01:00:00+01:00", "begin_effective": "2012-01-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2012-02-01T15:45:19+01:00", "program": 79, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 1, "manager": 51705, "contact": 51705, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2771-51705-10" ] }, { "id": 2370, "title": { "de": "GIRK Proteine in Brustkrebszellen", "en": "MOLECULAR AND CELLULAR (PATHO)PHYSIOLOGY OF G-PROTEIN ACTIVATED INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNITS IN BREAST CANCER CELLS" }, "short": "GIRK PROTEINE BREAST CANCER", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-10-01T02:00:00+02:00", "begin_effective": "2011-04-01T02:00:00+02:00", "end_planned": "2013-09-30T02:00:00+02:00", "end_effective": "2016-03-31T02:00:00+02:00", "assignment": "2010-12-28T14:50:01+01:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P22974", "ethics_committee": null, "edudract_number": null, "persons": [] } ] }