List projects.

Fields

id (integer)

Primary key.

Expansions

To activate relation expansion add the desired fields as a comma separated list to the expand query parameter like this:

?expand=<field>,<field>,<field>,...

The following relational fields can be expanded:

  • organization
  • category
  • type
  • partner_function
  • manager
  • contact
  • status
  • grant
  • research
  • event
  • study
  • language
  • program
  • funders

Filters

To filter for exact value matches:

?<fieldname>=<value>

Possible exact filters:

  • organization
  • category
  • manager
  • contact
  • status
  • grant
  • research
  • study
  • language
  • funders
  • program

For advanced filtering use lookups:

?<fieldname>__<lookup>=<value>

All fields with advanced lookups can also be used for exact value matches as described above.

Possible advanced lookups:

  • begin_planned: gt, gte, lt, lte
  • begin_effective: gt, gte, lt, lte
  • end_planned: gt, gte, lt, lte
  • end_effective: gt, gte, lt, lte
GET /v1/research/project/?format=api&offset=900&ordering=-begin_planned
HTTP 200 OK
  Allow: GET, HEAD, OPTIONS
  Content-Type: application/json
  Vary: Accept
  
  {
    "count": 2265,
    "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=920&ordering=-begin_planned",
    "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=880&ordering=-begin_planned",
    "results": [
        {
            "id": 6133,
            "title": {
                "de": "Prozess analytische Technologien für industrielle Nanopartikel Produktionen",
                "en": "Process Analytical Technologies for Industrial Nanoparticles Production"
            },
            "short": "NanoPAT",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-03-02T01:00:00+01:00",
            "begin_effective": "2020-06-01T02:00:00+02:00",
            "end_planned": "2024-03-04T01:00:00+01:00",
            "end_effective": "2024-05-31T02:00:00+02:00",
            "assignment": "2020-05-13T12:52:37+02:00",
            "program": 109,
            "subprogram": null,
            "organization": 14011,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 86770,
            "contact": null,
            "status": 2,
            "research": 3,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6133-86770-10",
                "6133-100187-12",
                "6133-107594-12"
            ]
        },
        {
            "id": 6267,
            "title": {
                "de": "Sirtuin 4 und Reaktive Radikale in der Kardioprotektion",
                "en": "The role of SIRT4 in myocardial ischemia reperfusion"
            },
            "short": "SIRT4 and ischemia reperfusion",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-03-01T01:00:00+01:00",
            "begin_effective": "2020-10-01T02:00:00+02:00",
            "end_planned": "2021-02-28T01:00:00+01:00",
            "end_effective": "2024-06-30T02:00:00+02:00",
            "assignment": "2020-09-07T16:18:39+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 100924,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P33874",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6267-108436-12",
                "6267-99418-12",
                "6267-100924-10",
                "6267-101037-12"
            ]
        },
        {
            "id": 6098,
            "title": {
                "de": "HOCHDOSIS-GLUKOKORTIKOID-THERAPIE VS. GLUKOKORTIKOID-SUBSTITUTION IN DER THERAPIE DER IMMUN-CHECKPOINT-INHIBITOR-VERMITTELTEN HYPOPHYSITIS: EINE OFFENE, RANDOMISIERTE STUDIE",
                "en": "GLUCOCORTICOID HIGH-DOSE VS. REPLACEMENT IN IMMUNE CHECKPOINT INHIBITOR ASSOCIATED HYPOPHYSITIS: AN OPEN, RANDOMIZED TRIAL"
            },
            "short": "CORTICI",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-03-01T01:00:00+01:00",
            "begin_effective": "2020-01-01T01:00:00+01:00",
            "end_planned": "2023-02-28T01:00:00+01:00",
            "end_effective": "2024-02-29T01:00:00+01:00",
            "assignment": "2020-03-16T12:01:56+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14080,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 71449,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": "18377",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6098-71449-10"
            ]
        },
        {
            "id": 6260,
            "title": {
                "de": "Gehirnprotektion für sehr kleine Frühgeborene",
                "en": "Safeguarding the brain of our smallest children"
            },
            "short": "SafeBoosC III",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-03-01T01:00:00+01:00",
            "begin_effective": "2020-03-01T01:00:00+01:00",
            "end_planned": "2022-02-28T01:00:00+01:00",
            "end_effective": "2022-04-30T02:00:00+02:00",
            "assignment": "2020-08-26T17:14:39+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14094,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 50907,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6260-50907-10"
            ]
        },
        {
            "id": 6023,
            "title": {
                "de": "Untersuchungen der immunregulatorischen Funktion von NR4A1/Nr4a1 in aggressiven Lymphomen",
                "en": "Investigating the immune-regulatory function of NR4A1/Nr4a1 in aggressive lymphomas"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-03-01T01:00:00+01:00",
            "begin_effective": "2020-03-01T01:00:00+01:00",
            "end_planned": "2022-03-28T02:00:00+02:00",
            "end_effective": "2022-03-28T02:00:00+02:00",
            "assignment": "2020-01-16T15:26:47+01:00",
            "program": 116,
            "subprogram": null,
            "organization": 14082,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 100134,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                15
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6023-100134-10",
                "6023-59183-12",
                "6023-79614-12",
                "6023-119850-12"
            ]
        },
        {
            "id": 5968,
            "title": {
                "de": "Multiskalenveränderungen im Knochen durch biologisch resorbierbare Implantate: Vorhersage der Struktur und der mechanischen Leistung",
                "en": "Multiscale changes in bone due to bio-resorbable implants: towards a\r\nprediction of structure and mechanical performance"
            },
            "short": "SAXStomo",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-03-01T01:00:00+01:00",
            "begin_effective": "2020-06-01T02:00:00+02:00",
            "end_planned": "2023-02-28T01:00:00+01:00",
            "end_effective": "2024-05-31T02:00:00+02:00",
            "assignment": "2019-11-26T14:09:07+01:00",
            "program": 111,
            "subprogram": null,
            "organization": 14052,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 50785,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "I4409",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "5968-50785-10",
                "5968-96335-12",
                "5968-98087-12",
                "5968-107169-12",
                "5968-113631-12",
                "5968-114967-12"
            ]
        },
        {
            "id": 5986,
            "title": {
                "de": "Neuer Knochen in Lithoz 380D Gerüst in Rattencalvarien und prox. Tibia",
                "en": "New Bone in Lithoz TCP 380D Scaffold in Rat Calvaria and prox. Tibia"
            },
            "short": "Lithoz 380D",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-03-01T01:00:00+01:00",
            "begin_effective": "2020-03-01T01:00:00+01:00",
            "end_planned": "2021-09-30T02:00:00+02:00",
            "end_effective": "2023-12-31T01:00:00+01:00",
            "assignment": "2019-12-09T10:47:00+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14052,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 96335,
            "contact": null,
            "status": 2,
            "research": 3,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "5986-96335-10"
            ]
        },
        {
            "id": 5963,
            "title": {
                "de": "Programmierung der Funktion von endothelialen Vorläuferzellen durch mütterlichen Metabolismus und Einfluss des fetalen Geschlechts ",
                "en": "Programming the function of fetal endothelial progenitor cells by maternal metabolism and influences of fetal sex"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-02-10T01:00:00+01:00",
            "begin_effective": "2020-02-10T01:00:00+01:00",
            "end_planned": "2020-05-24T02:00:00+02:00",
            "end_effective": "2020-05-24T02:00:00+02:00",
            "assignment": "2019-11-20T09:12:39+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14038,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 100010,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                431
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "5963-100010-10"
            ]
        },
        {
            "id": 6049,
            "title": {
                "de": "Der Effekt von Rauchen in der Schwangerschaft auf Entwicklung in der frühen Schwangerschaft - eine single-cell multi-omics Studie",
                "en": "Maternal Smoking and its effect on early gestational development – a single-cell multi-omics\r\napproach"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-02-01T01:00:00+01:00",
            "begin_effective": "2020-02-01T01:00:00+01:00",
            "end_planned": "2021-02-28T01:00:00+01:00",
            "end_effective": "2024-12-31T01:00:00+01:00",
            "assignment": "2020-02-10T13:48:05+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14017,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 89664,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-48",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6049-89664-10"
            ]
        },
        {
            "id": 6050,
            "title": {
                "de": "Europlanet 2024",
                "en": "Europlanet 2024"
            },
            "short": "EPN 2024 RI",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-02-01T01:00:00+01:00",
            "begin_effective": "2020-02-01T01:00:00+01:00",
            "end_planned": "2024-01-31T01:00:00+01:00",
            "end_effective": "2024-07-31T02:00:00+02:00",
            "assignment": "2020-02-10T16:35:51+01:00",
            "program": 109,
            "subprogram": null,
            "organization": 14023,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 90021,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": "871149",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6050-90021-10",
                "6050-91470-12",
                "6050-100035-12"
            ]
        },
        {
            "id": 6152,
            "title": {
                "de": "Supplementierung von omega-3 Fettsäuren als Ergänzung zur intravitrealen Therapie des diabetischen Makulaödems",
                "en": "Omega-3 fatty acids supplementation as adjunct to intravitreal treatment of \r\ndiabetic macular edema\r\n"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-02-01T01:00:00+01:00",
            "begin_effective": "2020-02-01T01:00:00+01:00",
            "end_planned": "2021-05-01T02:00:00+02:00",
            "end_effective": "2023-01-31T01:00:00+01:00",
            "assignment": "2020-06-05T11:00:45+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14043,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50850,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2194
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6152-50850-10"
            ]
        },
        {
            "id": 6051,
            "title": {
                "de": "Untersuchungen zu immunregulatorischen Funktion von Nr4a1 in aggressiven Lymphomen",
                "en": "Investigation of the immunregulorischen Funktion von Nr4a1 in aggressive lymphoma"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-02-01T01:00:00+01:00",
            "begin_effective": "2020-02-01T01:00:00+01:00",
            "end_planned": "2021-06-30T02:00:00+02:00",
            "end_effective": "2021-06-30T02:00:00+02:00",
            "assignment": "2020-02-11T09:56:56+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14082,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 59183,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-35",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6051-59183-10"
            ]
        },
        {
            "id": 6090,
            "title": {
                "de": "Nutzung der Elektro-transkriptionellen Kopplung zur Behandlung von hypertensiven Kardiomyopathien",
                "en": "Targeting Excitation-Transcription Coupling for Managing Hypertensive Cardiomyopathy"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-02-01T01:00:00+01:00",
            "begin_effective": "2020-02-01T01:00:00+01:00",
            "end_planned": "2024-01-31T01:00:00+01:00",
            "end_effective": "2024-12-31T01:00:00+01:00",
            "assignment": "2020-03-06T12:12:19+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 62747,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2325
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6090-62747-10",
                "6090-75758-12",
                "6090-105142-12",
                "6090-110709-12",
                "6090-117943-12",
                "6090-126115-12",
                "6090-122231-12"
            ]
        },
        {
            "id": 5978,
            "title": {
                "de": "Der digital-unterstützte Medikationsprozess im Krankenhaus: Chancen, Herausforderungen, Kompetenzentwicklung für mehr MitarbeiterInnen- und PatientInnensicherheit in der Steiermark",
                "en": "The digitally supported medication process in hospitals: opportunities, challenges, competence development "
            },
            "short": "MeDi-Pro",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-01-07T01:00:00+01:00",
            "begin_effective": "2020-01-07T01:00:00+01:00",
            "end_planned": "2021-12-23T01:00:00+01:00",
            "end_effective": "2021-12-31T01:00:00+01:00",
            "assignment": "2019-12-05T11:37:39+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14080,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 65558,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                55
            ],
            "funder_projectcode": "GZ: ABT08-165397/2019  PN:1204",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "5978-54235-12",
                "5978-65558-10"
            ]
        },
        {
            "id": 6000,
            "title": {
                "de": "Die Kataraktogenese aus Sicht der modernen Biophysik",
                "en": "Cataractogenesis in the light of modern biophysics "
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-01-02T01:00:00+01:00",
            "begin_effective": "2020-01-02T01:00:00+01:00",
            "end_planned": "2021-12-31T01:00:00+01:00",
            "end_effective": "2021-12-31T01:00:00+01:00",
            "assignment": "2019-12-16T09:27:28+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14043,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2194
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 6048,
            "title": {
                "de": "Efficient Ex Vivo Evaluation of Combined Immunotherapies for Diffuse Large B Cell Lymphoma",
                "en": "Efficient Ex Vivo Evaluation of Combined Immunotherapies for Diffuse Large B Cell Lymphoma"
            },
            "short": "Immunotherapies for Lymphoma",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-01-01T01:00:00+01:00",
            "begin_effective": "2020-07-01T02:00:00+02:00",
            "end_planned": "2020-12-31T01:00:00+01:00",
            "end_effective": "2025-12-31T01:00:00+01:00",
            "assignment": "2020-02-10T13:46:22+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14017,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 94195,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-47",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6048-94195-10"
            ]
        },
        {
            "id": 6236,
            "title": {
                "de": "Effekte der Skalpakupunktur auf die Herzratenvariabilität bei Patienten mit Schlafstörungen",
                "en": "Effects of Scalp Acupuncture on Heart Rate Variability in Patients with Insomnia"
            },
            "short": "Skalp Akupunktur - HRV - EPU2020",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-01-01T01:00:00+01:00",
            "begin_effective": "2020-07-01T02:00:00+02:00",
            "end_planned": "2020-12-31T01:00:00+01:00",
            "end_effective": "2022-02-28T01:00:00+01:00",
            "assignment": "2020-08-10T10:39:54+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14044,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                762
            ],
            "funder_projectcode": "EPU 35/2019",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 5941,
            "title": {
                "de": "Multiskalen-Modellierung von Herzklappenerkrankungen",
                "en": "Multiscale Modeling of Valvular Heart Diseases - Understanding the Mechanisms of Adverse Remodeling to Improve Precision Medicine."
            },
            "short": "SICVALVES",
            "url": null,
            "abstract": {
                "de": "SICVALVES – Multiskalen-Modellierung von Herzklappenerkrankungen\r\n\r\nMotivation: Herzklappenerkrankungen sind eine zunehmende gesundheitliche Belastung für die alternde Bevölkerung, bei der allein die Aortenklappenstenose bei mehr als 12% der Patienten >70 Jahre vorherrscht. Es ist eine chronisch-progressive Erkrankung, die mit Geschlecht und Alter variiert. Bestehende Leitlinien für die Behandlungsplanung verwenden jedoch nur grobe Funktionsparameter, die die interindividuelle Variabilität nicht berücksichtigen und weit von den Anforderungen der Präzisionsmedizin entfernt sind. Im Zeitalter der digitalen Medizin haben Computermodelle das Potenzial, wichtige pathophysiologische Mechanismen zu entschlüsseln und zur personalisierten Präzisionsmedizin beizutragen.\r\nZiele: Die Nutzung fortgeschrittener Modelle auf Zell-, Gewebe- und Organebene, um mechanistische Erkenntnisse über Auslöser von ventrikulären Arrhythmien, diastolischer und systolischer Dysfunktion und myokardialen metabolischen Veränderungen zu gewinnen und zu untersuchen wie sich diese Prozesse gegenseitig verstärken. Geschlechtsspezifische Unterschiede müssen systematisch berücksichtigt werden. Letztlich sollen die Modelle zur Verbesserung der Diagnostik, Risikobewertung und Behandlungsplanung von Herzklappenerkrankungen beitragen.\r\nMethoden: Basierend auf unseren bisherigen Arbeiten werden wir bestehende computergestützte Modelle der Biomechanik, Elektrophysiologie und der Hämodynamik technologisch weiterentwickeln, testen und validieren. Zur Modellparametrisierung verwenden wir bestehende multidimensionale klinische Daten (Bildgebung, Sensortechnik, Systembiologie) aus eigenen früheren Untersuchungen bei Patienten mit Herzklappenerkrankungen. Die Validierung der Genauigkeit der Modelle zur Vorhersage von mechanistischen Veränderungen erfolgt anhand von Daten, die vor und nach dem Einsatz von künstlichen Klappenprothesen gewonnen werden.\r\nInnovation: Fortgeschrittene computergestützte Werkzeuge werden dafür genutzt, um personalisierte Modelle zu erstellen und diese zur quantitativen Bewertung von hypertropischem Remodeling und der Neigung zu Arrhythmien zu verwenden. Es werden vollständig neue Methoden entwickelt um  zugrunde liegenden Mechanismen, Verlauf und Symptome die bei Herzklappenerkrankungen auftreten zu verstehen. Des Weiteren wird ein virtueller Simulator für die patientenspezifische Planung der Therapie von Herzklappenerkrankungen entwickelt, der die Wirksamkeit der künstlichen Klappenprothesen verbessert und die Sterblichkeit bei Patienten reduziert.",
                "en": "SICVALVES – Multiscale modeling of  Valvular Heart Diseases\r\nUnderstanding the mechanisms of adverse remodeling to improve precision medicine\r\n\r\nBackground: Valvular Heart Diseases (VHD) are a detrimental health burden to the aging population where aortic valve stenosis alone has reached an incidence of more than 12% of patients >70y. It is a chronic-progressive disease that varies with gender and age. If left untreated, VHDs can cause malignant arrhythmias and severe heart failure. However, existing guidelines for treatment planning are using only rough function parameters that fail to account for inter-individual variability and are far away from the demands of precision medicine. In the age of digital medicine, computational modeling has the potential to unveil important pathophysiological mechanisms and to contribution towards personalized precision medicine.\r\nObjectives: To use advanced models of the cell, tissue, and organ level in VHD to gain mechanistic insights about triggers of ventricular arrhythmias, diastolic, and systolic dysfunction and myocardial metabolic alterations and how these processes reinforce each other. Gender differences will be systematically taken into account. Ultimately, models shall contribute to improve diagnostics, risk assessment, and treatment planning of VHDs.\r\nMethods: Based on our previous work, we will technologically advance, test, and validate existing computational models of biomechanics, electrophysiology, and hemodynamics. For model parameterization we use existing multidimensional clinical data (imaging, sensors, omics) from own previous research in patients with VHD (obtained before and after valve replacement). Validation of the model's accuracy to predict mechanistic changes will be done with data obtained before and after aortic valve replacement.\r\nInnovation: Advanced computational models will be leveraged to build personalized models and use these for quantitative assessment of hypertrophic remodeling and propensity for arrhythmias. Novel methodologies will be developed to understand important mechanisms of adverse remodeling in VHDs, as well as to improve patient care by optimizing patient selection and precision treatment planning in valve disease."
            },
            "begin_planned": "2020-01-01T01:00:00+01:00",
            "begin_effective": "2020-05-01T02:00:00+02:00",
            "end_planned": "2022-12-31T01:00:00+01:00",
            "end_effective": "2024-08-31T02:00:00+02:00",
            "assignment": "2019-10-28T13:38:14+01:00",
            "program": 112,
            "subprogram": null,
            "organization": 14011,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 79791,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "I4652",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "5941-79791-10",
                "5941-91352-12",
                "5941-119147-12",
                "5941-122514-12"
            ]
        },
        {
            "id": 6056,
            "title": {
                "de": "Entzündung und Stoffwechsel bei pulmonaler Hypertonie stehen im Zusammenhang mit der Inaktivierung des Chromosoms X: neue therapeutische Möglichkeiten",
                "en": "Inflammation and Metabolism in Pulmonary Hypertension are Linked to skewed chromosome X Inactivation: new therapeutic optiONS"
            },
            "short": "IMPHLeXIONS",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-01-01T01:00:00+01:00",
            "begin_effective": "2020-05-04T02:00:00+02:00",
            "end_planned": "2022-12-31T01:00:00+01:00",
            "end_effective": "2024-06-30T02:00:00+02:00",
            "assignment": "2020-02-13T11:19:46+01:00",
            "program": 112,
            "subprogram": null,
            "organization": 14006,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 62748,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "I4651",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6056-96765-12",
                "6056-62748-10",
                "6056-108817-12"
            ]
        },
        {
            "id": 6017,
            "title": {
                "de": "Tracking General Movements - An Observing‐the‐Observer Approach   to Understand and Enhance Clinical Reasoning   for the General Movement Assessment",
                "en": "Tracking General Movements - An Observing‐the‐Observer Approach   to Understand and Enhance Clinical Reasoning   for the General Movement Assessment"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-01-01T01:00:00+01:00",
            "begin_effective": "2020-04-01T02:00:00+02:00",
            "end_planned": "2023-12-31T01:00:00+01:00",
            "end_effective": "2025-09-30T02:00:00+02:00",
            "assignment": "2020-01-09T12:00:04+01:00",
            "program": 108,
            "subprogram": null,
            "organization": 14068,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 58883,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "KLI811",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6017-88853-11",
                "6017-58883-10"
            ]
        }
    ]
}