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GET /v1/research/project/?format=api&offset=820&ordering=begin_effective
{ "count": 2140, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=840&ordering=begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=800&ordering=begin_effective", "results": [ { "id": 3338, "title": { "de": "Rolle von Tumorstammzell-assoziierten non-coding RNAs beim hepatozellulären Karzinom", "en": "Role of stem cell-associated non-coding RNAs in hepatocellular carcinoma" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2013-07-18T16:36:18+02:00", "program": 81, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 53557, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 52 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3338-53557-10" ] }, { "id": 3376, "title": { "de": "Netzwerk für Innovation, Transfer und Verwertung von Medizinprodukten", "en": "Dynamic Network Arranged for Medical Device Innovation, Transfer & Exploitation" }, "short": "DYNAMITE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2015-12-31T01:00:00+01:00", "assignment": "2013-09-18T13:27:30+02:00", "program": 104, "subprogram": "Kooperation und Netzwerke", "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "840131", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3321, "title": { "de": "Hormonale Regulation der Lipolyse", "en": "Hormonal regulation of lipolysis" }, "short": "Hormonal regulation of lipolysis", "url": null, "abstract": { "de": "Lipasen, das sind Fett spaltende Enzyme, spielen eine wichtige Rolle im Energiestoffwechsel. Beeinträchtigungen ihrer Funktion verursachen Störungen in der Aufnahme, in der Mobilisierung und im Transport von Fetten, sog. Lipiden, und führen zu Lipid-assoziierten Krankheiten, z.B. Typ 2 Diabetes, Atherosklerose und Leberkrankheiten, aber auch Krebs. Die Kontrolle der Lipolyse ist wichtig für das Gleichgewicht des Energiehaushalts und die Verteilung der Fettdepots im Körper. Die Freisetzung von Fettsäuren ist abhängig von der Lipolyse von Triacylglyzeriden und wird neural und hormonal reguliert, um den Energiebedarf zu stillen. Die molekularen Mechanismen dieser Regulation sind noch nicht vollständig erforscht, aber posttranslationelle Proteinmodifikationen, Proteininteraktionen, Proteinlokalisierung und Zugang der Lipasen zu ihrem Substraten, den Lipiden, scheinen eine große Rolle zu spielen. Phosphorylierung der Hormonsensitiven Lipase, des Perilipins und der Adipose Triglyzerid Lipase wurde an verschiedenen Stellen durch verschiedene Kinasen beschrieben. Die Regulation und Funktion der Phosphorylierungsstellen wird aber ungenügend verstanden. Auch ist nichts über die Regulation anderer wichtiger Lipasen und Regulatoren, wie der Monoglyzerid Lipase, CGI-58 und G0/G1 Switch Gen 2, bekannt.\r\nWir haben eine analytische Plattform zur Detektion, vergleichenden Analyse und Visualisierung von Lipasen in lebenden Zellen und Geweben etabliert. In unseren Studien haben wir wiederholt Proteinisoformen der Lipasen detektiert. Außerdem haben wir kürzlich entdeckt, dass CGI-58 phosphoryliert wird. Zusammenfassend weisen unsere Studien, sowie die Studien anderer, auf die Existenz von Lipolyseproteinkomplexen hin, die über Phosphorylierung reguliert werden. Ziel des Projekts ist es daher, die Regulation des Lipidgleichgewichts besser zu verstehen. Dazu werden wir untersuchen, ob Lipasen und ihre Regulatoren phosphoryliert werden, ob und wie Lipolyseproteinkomplexe im Fettgewebe hormonell reguliert werden, und welche Funktionen neue Phosphorylierungsstellen und Proteininteraktionspartner von Lipasen und Regulatoren haben. Dadurch wird auch zum ersten Mal das lipolytische Proteom in humanen Fettgewebe direkt auf der Enzymaktivitätsebene erschlossen, was zum besseren Verständnis der Lipid-Mobilisierung in gesundem Gewebe führen wird, und so neue Therapieansätze für Lipid-assoziierte Krankheiten eröffnen wird.\r\n\r\n", "en": "Lipases play a key role in regulation of whole body energy homeostasis. Control of lipolysis is important for energy partitioning and balance and maintains the size of fat depots in the body. Dysregulation of lipolytic activities affects lipid absorption, mobilization and transport, and is causative for lipid-related diseases. The release of free fatty acids is dependent on the lipolysis of stored triacylglycerol which is tightly controlled by neural regulation and several hormones to meet energy demands. Molecular mechanisms of this regulation are poorly understood but post-translational modification, protein interactions, protein localizations and access of lipases to their substrates appear to play a major role. Phosphorylation of hormone sensitive lipase, the lipolysis regulator perilipin 1 and more recently also adipose triglyceride lipase (ATGL) have been described on various sometimes controversial sites by different sometimes unknown kinases. Regulations and functions of described sites, however, are poorly understood. Moreover, no information is yet available on regulation of other important players, such as monoglyceride lipase or the ATGL regulators comparative gene identification 58 (CGI-58/ABHD-5) and G0/G1 switch gene 2.\r\nWe have established an analytical platform for activity-based discovery, detection, profiling and imaging of lipolytic enzymes in intact cells and tissues. In our activity-based proteomic screens we have repeatedly detected active isoforms of lipases suggesting that they are posttranslationally modified. Moreover, we have recently discovered a novel post translational modification of CGI-58 by protein kinase A. Previous work by others and us points thus towards the existence of lipolytic complexes and post translational modification of the involved proteins, warranting a comprehensive screen for novel regulators of lipolysis.\r\nThe major objective of the proposed project Hormonal regulation of lipolysis is to provide a better understanding of the regulation of lipid homeostasis. We will perform in vitro kinase assays to search for novel substrates of known kinases among known lipolytic proteins and protein regulators, investigate the (phospho)proteomic effects of hormonal regulation on lipolytic complexes in murine and human tissues, and functionally analyze selected novel potential regulators of lipolysis (i.e. novel phosphosites, including our novel CGI-58 phosphosite, and/or novel interacting proteins).\r\nAlthough many protein functions appear to be conserved in humans and mice there is growing evidence for important interspecies differences, especially in complex diseases caused by genetic and environmental factors, which cannot be easily reproduced in model organisms. While activity-based probes were already successfully employed to identify novel lipolytic enzymes in mouse liver and adipose tissue homogenates, this study will for the first time shed light on the lipolytic proteome of human adipose tissues in situ directly at enzymatic activity level. Combined with standard quantitative (phospho)proteomic profiling relevant regulators of lipolytic activities will be identified and might offer entry points for future therapies.\r\n\r\n\r\n" }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2016-07-31T02:00:00+02:00", "end_effective": "2016-08-31T02:00:00+02:00", "assignment": "2013-07-10T10:40:38+02:00", "program": 72, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 58794, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P26074", "ethics_committee": null, "edudract_number": null, "persons": [ "3321-58794-10", "3321-96765-12" ] }, { "id": 3356, "title": { "de": "Elterlicher Stress bei Frühgeburt und pränatale Vorbereitung", "en": "Stress in parents of preterm infants and preparation of preterm birth" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2014-08-31T02:00:00+02:00", "end_effective": "2014-08-31T02:00:00+02:00", "assignment": "2013-08-21T16:06:03+02:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 50907, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3356-50907-10" ] }, { "id": 3340, "title": { "de": "Methylierungsanalysen von zirkulierenden Tumorzellen und weißen Blutzellen bei Brustkrebspatientinnen", "en": "Methylation analysis of circulating tumor cells and white blood cells in breast cancer patients" }, "short": null, "url": null, "abstract": { "de": "Die Identifizierung von zirkulierenden Tumorzellen (CTCs) spielt eine zunehmende Rolle in der effektiven und zielgerichteten Behandlung von Mammakarzinom Patientinnen. CTCs kommen im Blut sehr selten vor, sodass ihr Nachweis und ihre Charakterisierung eine tech- nologische Herausforderung darstellen. Molekulare Charakterisierung, wie die DNA Methylierung von CTCs, ist wichtig um neue biologische Informationen zu bekommen.\r\nWir beabsichtigen einen neuen Filter zur größenbasierten Anreicherung und Methylierungs- analyse von CTCs einzusetzen, um zu prüfen ob dieser Mikrofilter geeignet ist, sowohl CTCs und parallel beim gleichen Patienten weißen Blutzellen epigenetisch zu charakterisieren.", "en": "Identification of circulating tumor cells (CTCs) is increasingly playing an important role in the effective and targeted treatment of breast cancer patients. CTCs are very rare in the blood stream, making their isolation and characterization a major technological challenge. Molecular characterization, such as DNA methylation analysis of CTCs, is important to help extract information about their biology.\r\nWe propose to use a novel size-based microfilter to enrich for CTCs and analyze methylation in CTCs, thus evaluating the microfilter platform for its applicability to epigenetically characterize both CTCs and white blood cells from the same patient." }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2016-08-31T02:00:00+02:00", "end_effective": "2016-08-31T02:00:00+02:00", "assignment": "2013-07-22T10:39:23+02:00", "program": 79, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 50563, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3340-59188-12", "3340-50563-10", "3340-88082-12", "3340-105079-12", "3340-110608-12" ] }, { "id": 3325, "title": { "de": "Neue Biomarker für die Voraussage der Wirkung von Krebsmedikamenten bei Dickdarmkrebs [Charakterisierung von neuen prädiktiven Biomarkern bei Kolorektalkarzinom]", "en": "Characterization of novel predictive biomarkers in colorectal cancer patients treated with EGFR-targeting therapies" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2016-08-30T02:00:00+02:00", "end_effective": "2017-04-30T02:00:00+02:00", "assignment": "2013-07-10T15:42:33+02:00", "program": 79, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 58814, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3325-58814-10", "3325-53557-12" ] }, { "id": 3455, "title": { "de": "Dyslexie und Strabismus: Vision und Perzeption", "en": "Dyslexie und Strabismus: Vision und Perzeption" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2015-02-28T01:00:00+01:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2013-12-03T12:45:45+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 77049, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3455-58883-11", "3455-51583-11", "3455-77049-10" ] }, { "id": 3251, "title": { "de": "Darmflora bei metabolischem Syndrom: Einfluss eines probiotischen Milchgetränks", "en": "Gut microbiota in metabolic syndrome: Influence of a probiotic milk drink " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2014-04-01T02:00:00+02:00", "end_effective": "2014-04-01T02:00:00+02:00", "assignment": "2013-04-24T12:09:12+02:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 50989, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3251-50989-10" ] }, { "id": 3558, "title": { "de": "Entwicklung von bioresorbierbaren Implantaten für Kinder", "en": "Development of bioresorbable implants for children with special regards to fracture healing and patient requirements" }, "short": "BRIC Phase 2", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2016-08-31T02:00:00+02:00", "end_effective": "2017-06-30T02:00:00+02:00", "assignment": "2014-02-07T10:34:22+01:00", "program": 95, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 3, "manager": 50785, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "840286", "ethics_committee": null, "edudract_number": null, "persons": [ "3558-50785-10" ] }, { "id": 3353, "title": { "de": "Vermeidung arterieller Hypotonie bei Frühgeborenen", "en": "Avoiding hypotension in preterm neonates (AHIP) - A randomised controlled study on near infrared spectroscopy monitoring of peripheral-muscle and cerebral oxygenation with defined interventions versus routine monitoring and treatment in preterm neonates" }, "short": "AHIP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2017-08-31T02:00:00+02:00", "assignment": "2013-08-14T16:35:13+02:00", "program": 79, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 50907, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3353-50907-10" ] }, { "id": 3803, "title": { "de": "CB1/CB2R-unabhängigen Signale durch Cannabinoids in Endothel ", "en": "CB1/CB2R-independent cannabinoid signaling in endothelium" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-10-01T02:00:00+02:00", "begin_effective": "2013-10-01T02:00:00+02:00", "end_planned": "2016-09-30T02:00:00+02:00", "end_effective": "2018-11-30T01:00:00+01:00", "assignment": "2014-11-06T16:11:55+01:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 60219, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 27238", "ethics_committee": null, "edudract_number": null, "persons": [ "3803-60219-10" ] }, { "id": 3418, "title": { "de": "Globale Initiative zur Gen-Umwelt-Interaktion für Diabetes / Adipositas Risiko", "en": "Global initiative on Gene-environment interaction on Diabetes/Obesity risk" }, "short": "Interconnect", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-10-01T02:00:00+02:00", "begin_effective": "2013-10-01T02:00:00+02:00", "end_planned": "2017-09-30T02:00:00+02:00", "end_effective": "2017-09-30T02:00:00+02:00", "assignment": "2013-11-05T10:22:26+01:00", "program": 24, "subprogram": "HEALTH", "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 51632, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "602068", "ethics_committee": null, "edudract_number": null, "persons": [ "3418-51632-10" ] }, { "id": 3484, "title": { "de": "Zell-basierte regenerative Medizin: Neue Herausforderungen für EU Legislatur und Governance", "en": "Cell-based regenerative medicine: new challenges for EU legislation and governance" }, "short": "EUCelLEX", "url": null, "abstract": { "de": null, "en": "This proposal aims at collecting and analysing facts and figures in order to assess the current legislation on\r\nthe therapeutic use of somatic cells, and to bridge it with the research infrastructure capacity building. Although\r\nEU has adopted 3 Directives on Tissues and cells between 2004 and 2006 to harmonise the procurement,\r\nstorage and use of cells for therapeutic use in Europe, countries have implemented these directives in very\r\ndifferent ways. Furthermore, research has been partially covered by the initial regulation, calling into question the\r\nmatch between regulation and practices that will develop in the near future, in particular with the emergence of\r\nEuropean research infrastructures. Finally many changes have occurred in the scientific, legal and institutional\r\nenvironment of cell use, leading to a necessary update of this regulation with regards to its implementation in\r\nnational legislation and its impact on research practice and innovation. Two domains are at stake: research\r\n(infrastructures) and medical practice/public health measures (cells). The therapeutic use of cells is regulated by\r\nEU law whereas its research counterpart is mainly depending on national laws and regulations. This gap calls for\r\na coordinated action in order to optimize the translational process, since the full pipeline is not coherently taken\r\ninto account in current legislations. To achieve these objectives, our project relies on a coherent consortium\r\nof experts in the fields of cells therapies, cells banks and translational biomedicine, having strong expertise\r\nin law and/ or in governance issues. After 36 months the project will deliver evidence about the contemporary\r\npractices around cells and will design a picture of the market and its distribution between the public and private\r\nsector. The project will thus help the Commission in the regulatory choices covering the use of human cells for\r\ntherapeutic purposes and to foster the innovation potential of related research activities." }, "begin_planned": "2013-10-01T02:00:00+02:00", "begin_effective": "2013-10-01T02:00:00+02:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2016-09-30T02:00:00+02:00", "assignment": "2013-12-20T12:06:22+01:00", "program": 24, "subprogram": "Health FP7-HEALTH-2013-INNOVATION-1", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "601806", "ethics_committee": null, "edudract_number": null, "persons": [ "3484-51663-10" ] }, { "id": 3333, "title": { "de": "Erhaltungsbehandlung und therapeutische Mechanismen von Psoralen+UVA (PUVA) bei Mycosis fungoides", "en": "Maintenance treatment and therapeutic mechanisms of psoralen+UVA (PUVA) in patients with mycosis fungoides " }, "short": "PUVA and mycosis fungoides", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-10-01T02:00:00+02:00", "begin_effective": "2013-10-01T02:00:00+02:00", "end_planned": "2016-09-30T02:00:00+02:00", "end_effective": "2018-09-30T02:00:00+02:00", "assignment": "2013-07-16T16:12:43+02:00", "program": 79, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 51618, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3333-54011-12", "3333-51618-10" ] }, { "id": 3388, "title": { "de": "Telomerlänge bei physiologischen Gehirnalterung und bei Alzheimer Demenz", "en": "Telomere length in physiological brain aging and Alzheimer`s dementia" }, "short": "Telomere and Brain Aging", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-10-01T02:00:00+02:00", "begin_effective": "2013-10-01T02:00:00+02:00", "end_planned": "2016-09-30T02:00:00+02:00", "end_effective": "2018-09-30T02:00:00+02:00", "assignment": "2013-09-30T12:12:04+02:00", "program": 79, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51912, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3388-51912-10" ] }, { "id": 3368, "title": { "de": "Auswirkung von Verkehrslärm im Freifeld", "en": "Evaluation of the influence of naturalistic road and rail traffic noise on both psychological and physiological parameters in the free field" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-05-01T02:00:00+02:00", "begin_effective": "2013-10-01T02:00:00+02:00", "end_planned": "2014-04-30T02:00:00+02:00", "end_effective": "2016-09-30T02:00:00+02:00", "assignment": "2013-09-09T16:52:17+02:00", "program": 72, "subprogram": null, "organization": 14024, "category": 10, "type": 10, "partner_function": 2, "manager": 51845, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P25747", "ethics_committee": null, "edudract_number": null, "persons": [ "3368-51845-10" ] }, { "id": 3651, "title": { "de": "Optimierung von körperlichem Training für die Prävention und Behandlung der Diastolischen Herzinsuffizienz", "en": "Optimizing Exercise Training in Prevention and Treatment of Diastolic Hert Failure" }, "short": "OptimEx", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-10-01T02:00:00+02:00", "end_planned": "2018-09-01T02:00:00+02:00", 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