Project List
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GET /v1/research/project/?format=api&offset=80&ordering=-begin_effective
{ "count": 2261, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=100&ordering=-begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=60&ordering=-begin_effective", "results": [ { "id": 9044, "title": { "de": "OSIP: Die Erneuerung der Werkzeuge für den Planetenschutz", "en": "OSIP: Modernizing planetary protection toolkits" }, "short": null, "url": null, "abstract": { "de": "Artikel IX des Weltraumvertrags (OST) (https://www.unoosa.org/oosa/en/ourwork/spacelaw/treaties/outerspacetreaty.html) verlangt, dass die Vertragsstaaten geeignete Maßnahmen ergreifen, um eine schädliche Verunreinigung von Himmelskörpern und nachteilige Veränderungen auf der Erde zu vermeiden. Die ESA handelt im Namen ihrer Mitgliedstaaten, die alle Vertragsparteien des Weltraumvertrags sind. Als solche müssen die Aktivitäten der ESA mit den Verpflichtungen der Mitgliedstaaten gemäß Artikel IX übereinstimmen. Die derzeitigen PP-Standards, die auf den Methoden der Viking-Mission der NASA aus den 1970er Jahren beruhen, sind veraltet. Unser Verständnis von mikrobiellem Leben hat sich weiterentwickelt, und so muss auch unser Ansatz für PP. Wir schlagen ein revolutionäres Projekt im Einklang mit der PP-Vision der ESA für 2026 vor (ESA-TECQI-TN-2024-000152). Unser Ziel ist es, den Standardtest (ECSS-Q-ST-70-55) mit einem hochmodernen probabilistischen Risikobewertungsmodell zu erweitern. Jüngste Forschungsarbeiten (Green et al., 2023) haben mehrere Wissenslücken aufgedeckt, wie z. B. die Überlebensfähigkeit von PP-relevanten Mikroorganismen, die wir nun systematisch angehen wollen. Zu diesem Zweck werden wir modernste Metagenomik als Schlüsseltechnologie zur Bewertung der Biodiversität und des Risikos von Vorwärts- und Rückwärtskontaminationen einsetzen. Durch die Integration von Echtzeit-Sequenzierungstechnologien wie Nanopore können wir zeitnah (<24h) ein Profil von Umgebungen mit geringer Biomasse erstellen und den Ingenieuren ermöglichen, Maßnahmen zu ergreifen. Um die Anpassung von Mikroben an Reinraum- und Raumfahrzeugumgebungen wirklich zu verstehen, werden wir Metabolitenvorhersagen auf Genomebene und Massenspektrometrie von Proteinen und Metaboliten durchführen. Wir planen die Entwicklung eines überwachten maschinellen Lernmodells, das metagenomische und massenspektrometrische Daten nutzt, um einen risikoinformierten Wert für die Überlebensfähigkeit von Mikroben in Reinräumen und auf Oberflächen von Raumfahrzeugen zu ermitteln. Unser innovativer Ansatz wird die PP-Toolkits modernisieren, den ESA-Missionsteams mehr Flexibilität und Effizienz bei der Implementierung von PP in Industrieunternehmen bieten und gleichzeitig die Unternehmensverpflichtungen der ESA zur Durchführung verantwortungsvoller und nachhaltiger Weltraumerkundungen erfüllen. Begleiten Sie uns auf diesem kühnen Weg, PP neu zu definieren und eine sichere und nachhaltige Zukunft in der Weltraumforschung zu gewährleisten.", "en": "Article IX of the Outer Space Treaty (OST) (https://www.unoosa.org/oosa/en/ourwork/spacelaw/treaties/outerspacetreaty.html) requires that State parties adopt appropriate measures to avoid harmful contamination of celestial bodies and adverse changes on Earth. ESA acts on behalf of its Member States, all of which are State parties to the OST. As such, ESA's activities shall comply with Member States' obligations to Article IX. The current PP standards, rooted in methodologies from the 1970s NASA Viking mission, are outdated. Our understanding of microbial life has evolved, and so must our approach to PP. We propose a revolutionary project in line with ESA’s PP vision for 2026 (ESA-TECQI-TN-2024-000152). Our goal is to enhance the standard assay (ECSS-Q-ST-70-55) with a cutting-edge probabilistic risk assessment model. Recent research (Green et al., 2023) has unveiled several knowledge gaps, such as the survivability of PP-relevant microorganisms, which we aim to address now systematically. For this, we will leverage state-of-the-art metagenomics as a key technology to assess biodiversity and the risk of forward and backward contaminations. By integrating real-time sequencing technologies like Nanopore, we can profile low biomass environments in a timely manner (<24h) and allow engineers to take action. To truly understand the adaptation of microbes to cleanroom and spacecraft environments, we will implement genome-scale metabolite predictions and mass spectrometry of proteins and metabolites. We plan to develop a supervised machine learning model that uses metagenomic and mass spectrometry data to provide a risk-informed value for the survivability of microbes from cleanrooms and spacecraft surfaces. Our innovative approach will modernize PP toolkits, provide more flexibility and increased efficiency to ESA mission teams when implementing PP inside industrial organizations while fulfilling ESA’s corporate obligations to conduct responsible and sustainable space explorations. Join us in this bold journey to redefine PP and ensure a safe and sustainable future in space exploration." }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2028-09-30T02:00:00+02:00", "end_effective": "2028-09-30T02:00:00+02:00", "assignment": "2025-06-20T11:55:25+02:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 3, "manager": 100035, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1203 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9044-90021-12", "9044-100035-10", "9044-113714-12" ] }, { "id": 9270, "title": { "de": "Strukturiertes Kommunikationstraining mit standardisierten Patient*innen für die antenatale neonatologische Beratung bei drohender Frühgeburt", "en": "Antenatal Counselling Training for expected preterm delivery using structured communication training with standardized patients" }, "short": "ACT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2025-10-15T18:28:23+02:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 1, "manager": 68534, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 97 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9270-68534-10" ] }, { "id": 9139, "title": { "de": "HER2-gerichteter M13-Bakteriophage als Träger für TRAIL zur gezielten Therapie von Brustkrebs", "en": "Targeted TRAIL delivery via HER2-specific M13 bacteriophage for breast cancer therapy" }, "short": "PHANTHER", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2027-09-30T02:00:00+02:00", "end_effective": "2027-09-30T02:00:00+02:00", "assignment": "2025-08-07T12:17:54+02:00", "program": 203, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 124253, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "ASEA 29/2025", "ethics_committee": null, "edudract_number": null, "persons": [ "9139-124253-10" ] }, { "id": 9083, "title": { "de": "Metabolische Signaturen und Reaktionsvorhersage unter Nährstoffentzug bei Brustkrebs", "en": "Metabolic Signatures and Response Prediction under Nutrient Deprivation in Breast Cancer" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2028-08-31T02:00:00+02:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-07-09T16:52:51+02:00", "program": 116, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 107135, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9083-107135-10" ] }, { "id": 9381, "title": { "de": "Der Einfluss von Schwangerschaft und Lebensstil auf die neuromotorische und kognitive Entwicklung von Säuglingen (PreStep Studie)", "en": "The Impact of Pregnancy and Lifestyle on Infants’ Neuromotor and Cognitive Development: Steps for Tomorrow (PreStep study)" }, "short": "PreStep study", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2029-08-31T02:00:00+02:00", "end_effective": "2029-08-31T02:00:00+02:00", "assignment": "2025-11-11T14:35:46+01:00", "program": 108, "subprogram": null, "organization": 14064, "category": 10, "type": 10, "partner_function": 2, "manager": 88993, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9381-88993-10" ] }, { "id": 8731, "title": { "de": "Metabolische und epigenetische Regulierung von Th9-Zellen", "en": "Metabolic and epigenetic regulation of Th9 cells" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-11-01T01:00:00+01:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2027-10-31T02:00:00+02:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-03-17T16:30:44+01:00", "program": 72, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": 78952, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT9714324", "ethics_committee": null, "edudract_number": null, "persons": [ "8731-78952-10" ] }, { "id": 9073, "title": { "de": "Identfying novel vulnerabilites in lung cancer utlizing advanced CRISPR approaches", "en": "Identfying novel vulnerabilites in lung cancer utlizing advanced CRISPR approaches" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2027-01-01T01:00:00+01:00", "end_effective": "2027-08-31T02:00:00+02:00", "assignment": "2025-07-07T13:31:38+02:00", "program": 116, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 2, "manager": 109501, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9073-109501-10" ] }, { "id": 9128, "title": { "de": "Erweiterte Realität für offenes anatomisches und medizinisches Erbe\r\nErkundung, Innovation und kulturelle Zugänglichkeit", "en": "eXtended Reality for Open Anatomical and Medical Heritage\r\nExploration, Innovation, and Cultural Accessibility" }, "short": "XR-Anatomica", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2028-08-31T02:00:00+02:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-08-04T17:22:16+02:00", "program": null, "subprogram": "Virtuelle und hybride Welten 2024", "organization": 14018, "category": 10, "type": 10, "partner_function": 2, "manager": 97024, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9128-97024-10", "9128-102804-12" ] }, { "id": 9072, "title": { "de": "Bioresorbierbare Mg-Fe Implantate in der Knochenheilung", "en": "Adapting bioresorbable Mg-Fe implants in bone healing" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-07-07T13:18:31+02:00", "program": 111, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 2, "manager": 98087, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PIN5073823", "ethics_committee": null, "edudract_number": null, "persons": [ "9072-98087-10" ] }, { "id": 9471, "title": { "de": "The impact of Pregnancy and Lifestyle factors on Infants’ Neuromotor and Cognitive Development: Steps for Tomorrow ", "en": "The impact of Pregnancy and Lifestyle factors on Infants’ Neuromotor and Cognitive Development: Steps for Tomorrow " }, "short": "PreStep study", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2029-08-30T02:00:00+02:00", "end_effective": "2029-08-30T02:00:00+02:00", "assignment": "2025-12-09T14:38:54+01:00", "program": 108, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 2, "manager": 58883, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLP3020124", "ethics_committee": null, "edudract_number": null, "persons": [ "9471-88853-11", "9471-58883-10" ] }, { "id": 9082, "title": { "de": "Der Einfluss von humanen p53 Varianten auf Gewichtsschwankungs-assoziierte Metaflammation", "en": "Impact of human p53 variants on metaflammation during weight cycling" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2028-08-31T02:00:00+02:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-07-09T15:54:23+02:00", "program": 116, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 124455, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9082-124455-10" ] }, { "id": 9382, "title": { "de": "Der Einfluss von Schwangerschaft und Lebensstil auf die neuromotorische und kognitive Entwicklung von Säuglingen: Schritte für morgen", "en": "The Impact of Pregnancy and Lifestyle on Infants’ Neuromotor and Cognitive Development: Steps for Tomorrow" }, "short": "PreStep", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2029-08-31T02:00:00+02:00", "end_effective": "2029-08-31T02:00:00+02:00", "assignment": "2025-11-11T14:37:29+01:00", "program": 108, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 2, "manager": 50907, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9382-50907-10" ] }, { "id": 9066, "title": { "de": "Effekt von Boswellia serrata auf Schmerzintensität, zentrale und periphere Sensibilisierung, Schmerzmodulation bei gesunden Proband:innen - eine randomisierte, doppelblinde, placebo-kontrollierte, cross-over Pilot-Prüfung\r\n", "en": "Effect of Boswellia serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Subjects – A Randomized, Double-Blind, Placebo-Controlled, Crossover Pilot Trial" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2026-03-01T01:00:00+01:00", "end_effective": "2026-04-30T02:00:00+02:00", "assignment": "2025-07-02T16:14:25+02:00", "program": null, "subprogram": null, "organization": 14069, "category": 10, "type": 10, "partner_function": 4, "manager": 101248, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9066-58422-11", "9066-101248-10" ] }, { "id": 9068, "title": { "de": "Zelltypspezifische in vivo Depletion proliferierender Zellen - Charakterisierung eines einzigartigen neuen genetischen Mausmodells", "en": "Cell-type specific in vivo ablation of proliferating cells – characterization of a unique novel genetic mouse model" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-08-01T02:00:00+02:00", "begin_effective": "2025-08-01T02:00:00+02:00", "end_planned": "2026-07-31T02:00:00+02:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2025-07-04T12:12:41+02:00", "program": null, "subprogram": null, "organization": 14006, "category": 10, "type": 10, "partner_function": 1, "manager": 61540, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9068-61540-10" ] }, { "id": 9568, "title": { "de": "OBELIX-NEPHROSE: B Zell Depletion in therapie-naiver MCD", "en": "OBELIX-NEPHROSIS: B CELLDEPLETION IN THERAPY-NAÏVE MCD" }, "short": "OBELIX-NEPHROSIS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-08-01T02:00:00+02:00", "end_planned": "2028-12-31T01:00:00+01:00", "end_effective": "2029-07-31T02:00:00+02:00", "assignment": "2026-01-29T13:31:32+01:00", "program": 111, "subprogram": null, "organization": 14084, "category": 10, "type": 10, "partner_function": 2, "manager": 100601, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9568-100601-10" ] }, { "id": 9130, "title": { "de": "Auf dem Weg zu einem umfassenden Atlas des menschlichen Atmungsmikrobioms: Taxonomische, genomische und funktionelle Perspektiven", "en": "Towards a Comprehensive Atlas of the Human Respiratory Microbiome: Taxonomic,\r\nGenomic, and Functional Perspectives" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-08-01T02:00:00+02:00", "end_planned": "2025-01-01T01:00:00+01:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2025-08-05T13:14:59+02:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 90021, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9130-90021-10" ] }, { "id": 9105, "title": { "de": "Zelluläre Lokalisation von Sbno2/SBNO2 in soliden Tumoren und kardiovaskulärem Gewebe", "en": "cellular localization of Sbno2/SBNO2 in solid tumors and cardio-vascular tissue" }, "short": "Zelluläre Lokalisation_Sbno2/SBNO2", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-07-01T02:00:00+02:00", "begin_effective": "2025-07-01T02:00:00+02:00", "end_planned": "2026-06-30T02:00:00+02:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2025-07-29T10:43:37+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 69755, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9105-69755-10", "9105-134141-12" ] }, { "id": 9104, "title": { "de": "Wirkung von S. auf die Adipozyten–Makrophagen-Kommunikation im Lipödem", "en": "Effect of S. on the adipocyte-macrophage-crosstalk in lipedema" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-07-01T02:00:00+02:00", "begin_effective": "2025-07-01T02:00:00+02:00", "end_planned": "2026-06-30T02:00:00+02:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2025-07-28T16:29:26+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 90806, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9104-90806-10" ] }, { "id": 9045, "title": { "de": "Die Bedeutung von IL-36-Signalübertragung und angeborenen Immunzellen bei pustulösen Hauterkrankungen", "en": "The role of IL-36 signaling and innate immune cells in pustular skin diseases" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-07-01T02:00:00+02:00", "begin_effective": "2025-07-01T02:00:00+02:00", "end_planned": "2027-06-30T02:00:00+02:00", "end_effective": "2027-06-30T02:00:00+02:00", "assignment": "2025-06-23T13:56:58+02:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 88082, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1983 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9045-88082-10" ] }, { "id": 9062, "title": { "de": "In-vitro-Untersuchung der ZX00-Implantate für die Bildung von Knorpelgewebe", "en": "In vitro investigation of the ZX00 implants for the cartilage tissue formation" }, "short": null, "url": null, "abstract": { "de": null, "en": "In children and adolescents, cartilage defects have significant impact on their quality of life due to impairment of joint function in older age. The refixation of loose cartilage, tissue engineering templates or refixation of cartilage after trauma are important to rescue the function of the knee joint. Consequently, the development of innovative techniques for fixation and the optimization of existing ones remain key priorities, driving extensive research efforts from basic science to clinical applications. In the last decade, magnesium (Mg)-based implants become promising alternatives in the orthopedic field because of its biocompatibility, good mechanical properties, biodegradability, and other functional properties. Our research group showed cartilage regeneration after putting an Mg-based screw through the joint surface and the growth plate in ovine model. Besides, tissue regeneration during degradation of the Mg-based screw did not lead to growth disturbances in comparison to titanium-based screws. However, the limited information about effects of Mg-based implants on chondrogenic differentiation, both in direct contact and as extract, point out the need for further investigations. Possible effects due to the alloying elements also need to be better understood. Therefore, this proposed study aims to investigate the potential effects of one of the most commonly used Mg-based implants, ZX00 alloy (Mg-Zn-Ca alloy) on cartilage tissue formation and provide a preliminary data for in vivo experiments.\r\n" }, "begin_planned": "2025-06-02T02:00:00+02:00", "begin_effective": "2025-07-01T02:00:00+02:00", "end_planned": "2026-06-01T02:00:00+02:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2025-06-30T11:23:18+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 102252, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1566 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9062-102252-10" ] } ] }