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GET /v1/research/project/?format=api&offset=780&ordering=begin_effective
{ "count": 2140, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=800&ordering=begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=760&ordering=begin_effective", "results": [ { "id": 3133, "title": { "de": "Graz Studie an Gesundheit und Altern", "en": "Graz Study on Health and Aging" }, "short": "GSHA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-12-01T01:00:00+01:00", "begin_effective": "2013-03-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2015-03-31T02:00:00+02:00", "assignment": "2013-01-14T14:45:13+01:00", "program": null, "subprogram": "Subventionsansuchen Stadt Graz", "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51912, "contact": 51912, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3133-51912-10" ] }, { "id": 5498, "title": { "de": "Anti-atherogene Wirkung neuer Paraoxonase Substrate ", "en": "Athero-protective effects of novel paraoxonase\r\nsubstrates" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-03-01T01:00:00+01:00", "begin_effective": "2013-03-01T01:00:00+01:00", "end_planned": "2014-02-28T01:00:00+01:00", "end_effective": "2014-03-31T02:00:00+02:00", "assignment": "2018-09-26T15:18:52+02:00", "program": null, "subprogram": "MUG-Start-Förderung", "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 62749, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5498-62749-10" ] }, { "id": 2916, "title": { "de": "ApoA-I und ApoJ beeinflussen den Amyloid-beta Metabolismus an der Blut-Hirn-Schranke", "en": "Implications of apoA-I and apoJ as modulators of amyloid beta metabolism in brain capillary endothelial cells of the blood-brain barrier" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-10-01T02:00:00+02:00", "begin_effective": "2013-03-01T01:00:00+01:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2018-02-28T01:00:00+01:00", "assignment": "2012-07-17T12:22:27+02:00", "program": 72, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P24783", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3180, "title": { "de": "Spiegelbestimmung ausgewählter antimikrobieller Substanzen im Liquor cerebrospinalis bei pädiatrischen, hämato-/onkologischen Patienten", "en": "Levels of selected antimicrobial agents in cerebrospinal fluid (CSF) of paediatric haemato-/oncologic patients" }, "short": "Antimicrobials in CSF", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-10-01T02:00:00+02:00", "begin_effective": "2013-03-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2017-03-31T02:00:00+02:00", "assignment": "2013-02-20T09:59:20+01:00", "program": null, "subprogram": "Land Steiermark < 5.000,- Euro", "organization": 14092, "category": 10, "type": 10, "partner_function": 4, "manager": 56810, "contact": 56810, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3180-56810-10" ] }, { "id": 3109, "title": { "de": "GENETISCHE ABERRATIONEN IN SUBTYPEN DES ADENOKARZINOMS DER LUNGE", "en": "Genetic aberrations in subtypes of pulmonary adenocarcinomas" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-03-15T01:00:00+01:00", "begin_effective": "2013-03-15T01:00:00+01:00", "end_planned": "2013-12-01T01:00:00+01:00", "end_effective": "2015-10-31T01:00:00+01:00", "assignment": "2012-12-13T14:59:25+01:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3225, "title": { "de": "Diagnostik und Klassifikation von pulmonaler Hypertonie mittels Herz-Magnetresonanzbildgebung ohne Einsatz von Kontrastmitteln", "en": "Non-contrast enhanced cardiac magnetic resonance imaging in the diagnosis and classification of pulmonary hypertension" }, "short": "CMR-PH2012", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-01-01T01:00:00+01:00", "begin_effective": "2013-03-25T01:00:00+01:00", "end_planned": "2014-12-31T01:00:00+01:00", "end_effective": "2015-12-31T01:00:00+01:00", "assignment": "2013-03-27T16:38:26+01:00", "program": null, "subprogram": null, "organization": 14104, "category": 10, "type": 10, "partner_function": 4, "manager": 53950, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3225-53950-10" ] }, { "id": 3222, "title": { "de": "GPR55 in der Entwicklung des Kolonkarzinoms", "en": "GPR55 in tumorigenesis and metastasis of colon cancer" }, "short": null, "url": null, "abstract": { "de": "GPR55 in der Entwicklung des Kolonkarzinoms\r\nG Protein gekoppelte Rezeptoren spielen eine wichtige Rolle im Tumorwachstum und in der Metastasierung von Krebszellen und stellen somit ein wichtiges pharmakologisches Target für die Krebstherapie dar. Auf Grund seiner fördernden Wirkung in der Proliferation und Invasion von Tumorzellen, aber auch in der Angiogenese, ist der G Protein gekoppelte Rezeptor 55 (GPR55) in jüngster Zeit als ein mögliches neues Target in Erscheinung getreten. Das bioaktive Phospholipid Lysophosphatidylinositol (LPI) ist seit längerem als der endogene Ligand des GPR55 Rezeptors bekannt. Erhöhte LPI Werte wurden im Ovarialkarzinom nachgewiesen und lassen auf einen Zusammenhang zwischen der LPI/GPR55 Achse und Krebswachstum schließen.\r\nGPR55 ist auch in Epithelzellen des Darmtrakts vorhanden, was auf eine mögliche Rolle in der Entwicklung des Kolonkarzinoms vermuten läßt. Im vorliegenden Projekt untersuchen wir die Funktion von GPR55 und LPI in der Tumorgenese und in der Metastasierung des Kolonkarzinoms zuerst an Hand der Kolonkarzinom Zelllinien HCT116 und SW480. Dabei werden Proliferations-, Apoptose-, Migration- und Invasionsassays verwendet ebenso wie molekularbiologische Methoden, um LPI-induzierte Signaltransduktionswege zu untersuchen. In einem Kolitis-assoziierten Kolonkarzinom Modell der Maus soll die Bedeutung von GPR55 in der Tumorentstehung in vivo untersucht werden, insbesondere ob GPR55 an der Proliferation von malignen Zellen und der Expression von onkogenen Transkriptionsfaktoren, wie NF-kappa B und STAT3, beteiligt ist. Die Rolle von GPR55 in der Verbreitung der Kolonkarzinomzellen in Sekundärorgane soll in einem in vivo Metastasierungsmodell untersucht werden. An Hand von histologischen Schnitten und Biopsien von humanem Kolonkarzinomgewebe wollen wir schließlich noch die Bedeutung von GPR55 und LPI in der Entstehung des Kolonkarzinoms beim Menschen untersuchen. Das Projekt sollte wesentliche Aussagen bezüglich einer möglichen pharmakologischen Therapie gegen Dickdarmkrebs basierend auf GPR55 geben. Weiters soll es eine Aussage liefern, ob LPI als möglicher Biomarker bei Dickdarmkrebs Verwendung finden könnte. \r\n", "en": null }, "begin_planned": "2013-06-01T02:00:00+02:00", "begin_effective": "2013-04-01T02:00:00+02:00", "end_planned": "2016-05-31T02:00:00+02:00", "end_effective": "2016-10-31T01:00:00+01:00", "assignment": "2013-03-26T10:24:55+01:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 56687, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P25633", "ethics_committee": null, "edudract_number": null, "persons": [ "3222-56687-10" ] }, { "id": 3160, "title": { "de": "Traumatische Epiphysenbrüche der unteren Extremitäten im Wachstumsalter Prospektive multizentrische Studie zu Aufkommen, Behandlungsstrategien und der Häufigkeit posttraumatischer Wachstumsstörungen.", "en": "Epiphyseal fractures of the lower extremity in children - A prospective multicenter study treatment strategies and incidence of posttraumatic growth arrest." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-04-01T02:00:00+02:00", "begin_effective": "2013-04-01T02:00:00+02:00", "end_planned": "2019-12-31T01:00:00+01:00", "end_effective": "2025-01-16T01:00:00+01:00", "assignment": "2013-01-29T09:42:27+01:00", "program": 103, "subprogram": "LiLa Licht und Lachen für kranke Kinder Effizienz in der Medizin e.V. ", "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 54144, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1450 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3160-54144-10" ] }, { "id": 3220, "title": { "de": "Rolle von micro RNAs in der Differenzierung von epidermalen Langerhanszellen", "en": "The role of micro RNAs in epidermal Langerhans cell differentiation" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-04-01T02:00:00+02:00", "begin_effective": "2013-04-01T02:00:00+02:00", "end_planned": "2016-03-31T02:00:00+02:00", "end_effective": "2017-07-31T02:00:00+02:00", "assignment": "2013-03-25T14:03:20+01:00", "program": 72, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": 79192, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P25720", "ethics_committee": null, "edudract_number": null, "persons": [ "3220-79192-10" ] }, { "id": 3230, "title": { "de": "Eye-Tracking mit 500Hz vs. 1250Hz: Höhere Abtastrate, neue Erkenntnisse...", "en": "Eye tracking with 500Hz vs. 1250Hz: Higher sampling rate, new findings¿" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-04-01T02:00:00+02:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-03-30T01:00:00+01:00", "assignment": "2013-04-11T10:33:06+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 77049, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3230-77049-10" ] }, { "id": 3322, "title": { "de": "Hochdurchsatzidentifizierung von molekularen Lipid Spezies aus LC-MS/MS Daten", "en": "High-Throughput Identification of Lipid Molecular Species in LC-MS/MS Data" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-04-01T02:00:00+02:00", "begin_effective": "2013-04-01T02:00:00+02:00", "end_planned": "2016-03-31T02:00:00+02:00", "end_effective": "2017-10-31T01:00:00+01:00", "assignment": "2013-07-10T10:41:55+02:00", "program": 72, "subprogram": null, "organization": 17225, "category": 10, "type": 10, "partner_function": 2, "manager": 58455, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P26148", "ethics_committee": null, "edudract_number": null, "persons": [ "3322-58455-10" ] }, { "id": 3335, "title": { "de": "Development of micro medical analyzer for ammonia monitoring in expiratory gas of critically ill", "en": "Development of micro medical analyzer for ammonia monitoring in expiratory gas of critically ill" }, "short": "AMMSE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-04-01T02:00:00+02:00", "begin_effective": "2013-04-01T02:00:00+02:00", "end_planned": "2016-03-31T02:00:00+02:00", "end_effective": "2016-09-30T02:00:00+02:00", "assignment": "2013-07-17T10:58:16+02:00", "program": 105, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": 58323, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "840940", "ethics_committee": null, "edudract_number": null, "persons": [ "3335-58323-10" ] }, { "id": 2911, "title": { "de": "Psoriasis, dysfunktionales HDL und koronare Herzkrankheit ", "en": "Psoriasis, dysfunctional HDL und coronary artery disease" }, "short": "Psoriasis verände3rt gutes Cholesterin", "url": null, "abstract": { "de": "Psoriasis, dysfunktionales HDL und koronare Herzkrankheit \r\n\r\nPsorias, eine chronisch entzündliche Hautererkrankung, betrifft etwa 3% der Menschen weltweit. Psoriasis ist ein eigenständiger erheblicher Risikofaktor für arterielle Erkrankungen des Herz-Kreislauf-Systems, die Ursachen für den beobachteten Zusammenhang sind jedoch unklar. In diesem Projektantrag soll untersucht werden, ob Psoriasis mit einer funktionellen Beeinträchtigung des high-density lipoproteins (HDL) assoziiert ist. Unter physiologischen Bedingungen vermittelt anti-atherogenes HDL den reversen Cholesterintransport und wirkt vaskuloprotektiv. Mittels massenspektroskopischen und biochemischen Analysen sollen Veränderungen im Proteom und in der Lipidzusammensetzung des HDL von Psoriasis Patienten im Vergleich zu gesunden Kontrollen untersucht werden. In weiterer Folge soll untersucht werden, ob eine veränderte HDL-Zusammensetzung mit einer funktionellen Beeinträchtigung des HDL-Partikels einhergeht. \r\n", "en": "Psoriasis, a very common skin disease, is nowadays considered as a systemic inflammatory condition. Psoriasis patients harbor an increased risk of myocardial infarction and stroke, and numerous studies indicate that psoriasis and cardiovascular disease - particularly atherosclerosis - share common pathogenic features. \r\nPatients with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis have decreased levels of high-density lipoprotein (HDL), suggesting that HDL may be important in preventing autoimmunity and the loss of self-tolerance. Proposed mechanisms for the atheroprotective functions of HDL include reverse cholesterol transport, reduction of oxidative stress and potent anti-inflammatory effects. On the other hand, HDL was shown to lose its-anti-atherogenic properties by post-translational modifications such as oxidation and carbamylation. There is emerging evidence suggesting that anti-atherogenic activities of HDL cannot be described by its plasma concentrations alone. For example, cholesterol efflux capacity, a functional measure of HDL, has an inverse association with the likelihood of coronary artery disease independent of HDL-cholesterol levels. Recent studies that elucidated the proteome of HDL from healthy individuals and patients with coronary artery disease or renal disease by mass spectrometry revealed that the protein cargo is a major determinant of the anti-atherogenic and anti-inflammatory properties of HDL. As qualitative alterations of HDL seem to be directly linked with increased cardiovascular complications, we hypothesize that HDL from psoriatic patients might display defective cholesterol efflux capability and anti-oxidative activities. \r\n" }, "begin_planned": "2012-10-01T02:00:00+02:00", "begin_effective": "2013-04-01T02:00:00+02:00", "end_planned": "2014-09-30T02:00:00+02:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2012-07-06T12:57:50+02:00", "program": 79, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 53252, "contact": 53252, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2911-53252-10" ] }, { "id": 3131, "title": { "de": "Schwangerschaftserkrankungen-Die Rolle von Metalloproteinasen und Endothelin", "en": "Pregnancy diseases - The role of metalloproteinases and endothelin" }, "short": "Schwangerschaftserkrankungen", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-10-01T02:00:00+02:00", "begin_effective": "2013-04-01T02:00:00+02:00", "end_planned": "2014-09-30T02:00:00+02:00", "end_effective": "2016-09-30T02:00:00+02:00", "assignment": "2013-01-07T16:00:05+01:00", "program": 79, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3179, "title": { "de": "Eine offene Simulationsumgebung zur Vorhersage von Behandlungserfolgen bei minimal invasiven Krebstherapien", "en": "A Generic Open-end Simulation Environment for Minimally Invasive Cancer Treatment" }, "short": "GoSmart", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-04-01T02:00:00+02:00", "end_planned": "2017-01-01T01:00:00+01:00", "end_effective": "2016-06-30T02:00:00+02:00", "assignment": "2013-02-19T13:34:26+01:00", "program": 24, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 2, "manager": 50874, "contact": 50874, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "600641", "ethics_committee": null, "edudract_number": null, "persons": [ "3179-62118-12", "3179-51955-10", "3179-51955-11", "3179-51955-12", "3179-50874-10", "3179-62756-12", "3179-98584-12" ] }, { "id": 3206, "title": { "de": "Genvarianten in Krebsstammzellen und Kolonkarzinom-Prognose", "en": "Cancer stem cell gene variants and colon cancer outcome" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-10-01T02:00:00+02:00", "begin_effective": "2013-04-01T02:00:00+02:00", "end_planned": "2013-09-30T02:00:00+02:00", "end_effective": "2014-03-31T02:00:00+02:00", "assignment": "2013-03-11T09:11:17+01:00", "program": 108, "subprogram": "KLIF", "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 58814, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI191", "ethics_committee": null, "edudract_number": null, "persons": [ "3206-50069-12", "3206-50910-12", "3206-58814-10" ] }, { "id": 3205, "title": { "de": "Analyse von RAS Mutationen in einem murinen in vivo Modell der akuten myeloischen Leukämie", "en": "Analysis of RAS mutations in a murine in vivo model of acute myeloid leukemia" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-04-15T02:00:00+02:00", "begin_effective": "2013-04-15T02:00:00+02:00", "end_planned": "2015-04-15T02:00:00+02:00", "end_effective": "2016-04-15T02:00:00+02:00", "assignment": "2013-03-08T14:51:46+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 57402, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3205-57402-10", "3205-77371-12", "3205-94596-12" ] }, { "id": 3320, "title": { "de": "Der Einfluss von perinatalen Parametern auf die zerebrale Oxygenierung von Neugeborenen am ersten Lebenstag", "en": "Influence of perinatal parameters on cerebral tissue oxygenation of newborn infants on the first day of life" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-05-01T02:00:00+02:00", "begin_effective": "2013-05-01T02:00:00+02:00", "end_planned": "2014-05-01T02:00:00+02:00", "end_effective": "2014-03-31T02:00:00+02:00", "assignment": "2013-07-09T16:27:55+02:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 73733, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3320-73733-10" ] }, { "id": 3252, "title": { "de": "Rolle von PGE2 und EP Rezeptoren in der pulmonalen Endothelfunktion", "en": "Regulatory role of PGE2 and EP receptors in pulmonary endothelial cell function" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-05-01T02:00:00+02:00", "end_planned": "2015-12-31T01:00:00+01:00", "end_effective": "2018-04-30T02:00:00+02:00", "assignment": "2013-04-25T10:48:46+02:00", "program": null, "subprogram": null, "organization": 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