GET
json api

Project List

List projects.

Fields

id (integer)

Primary key.

Expansions

To activate relation expansion add the desired fields as a comma separated list to the expand query parameter like this:

?expand=<field>,<field>,<field>,...

The following relational fields can be expanded:

  • organization
  • category
  • type
  • partner_function
  • manager
  • contact
  • status
  • grant
  • research
  • event
  • study
  • language
  • program
  • funders

Filters

To filter for exact value matches:

?<fieldname>=<value>

Possible exact filters:

  • organization
  • category
  • manager
  • contact
  • status
  • grant
  • research
  • study
  • language
  • funders
  • program

For advanced filtering use lookups:

?<fieldname>__<lookup>=<value>

All fields with advanced lookups can also be used for exact value matches as described above.

Possible advanced lookups:

  • begin_planned: gt, gte, lt, lte
  • begin_effective: gt, gte, lt, lte
  • end_planned: gt, gte, lt, lte
  • end_effective: gt, gte, lt, lte
GET /v1/research/project/?format=api&offset=740&ordering=end_effective
HTTP 200 OK
  Allow: GET, HEAD, OPTIONS
  Content-Type: application/json
  Vary: Accept
  
  {
    "count": 2265,
    "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=760&ordering=end_effective",
    "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=720&ordering=end_effective",
    "results": [
        {
            "id": 2957,
            "title": {
                "de": "VERHALTENSSTÖRUNGEN NACH VISZERALER IMMUNAKTIVIERUNG",
                "en": "PSYCHOPHARMACOLOGY OF THE VISCERAL IMMUNE – BRAIN AXIS"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": "Depression ist eine der häufigsten und schwersten affektiven Störungen, welche die Lebensqualität und Arbeitsfähigkeit der betroffenen Patienten massiv einschränkt und damit von enormer sozio-ökonomischer Bedeutung ist. Die Weltgesundheitsorganisation berichtet, dass Depression in der Altersklasse von 15 – 44 Jahren schon jetzt bei beiden Geschlechtern die zweithäufigste Ursache für „disability adjusted life years“ darstellt und die Zahl der von Depression betroffenen Patienten weiter steigt. Unglücklicherweise sprechen bis zu 40 % der Patienten mit Depression nur unzureichend auf die verfügbaren Antidepressiva an, was mit der Tatsache zusammenhängt, dass die Ätiologie affektiver Störungen nur unvollständig bekannt ist. Abgesehen von genetischen und psychosozialen Risikofaktoren rückt immer mehr auch eine chronische Stimulierung des Immunsystems als eine Ursache für die Entstehung affektiver Störungen in den Blickpunkt. Die Zytokin-Hypothese der Depression postuliert, dass systemische Immunprozesse über erhöhte Blutspiegel proinflammatorischer Zytokine einen Einfluss auf Gehirnfunktionen ausüben, die Ängstlichkeit, Affekt, Stressresistenz und kognitive Prozesse regulieren.\r\nAktivierung des viszeralen Immunsystems und viszerale Entzündung können mit einer Reihe von psychiatrischen Abnormalitäten assoziiert sind. Klinische Beobachtungen sprechen dafür, dass Translokation von Zellwandkomponenten des intestinalen Mikrobioms über eine pathologisch durchlässige Darmschleimhaut zu affektiven Störungen führen kann. Präklinische Befunde belegen, dass gastrointestinale Infektionen, gastrointestinale Entzündungen und intraperitoneale Verabreichung bakteriellen Endotoxins emotional-affektive Verhaltensänderungen auslöst. Vor diesem Hintergrund ist es das Ziel des vorgelegten Projekts, in einem experimentellen Ansatz depressive Verhaltensänderungen nach viszeraler Immunstimulierung in umfassender und innovativer Weise zu analysieren und neue Angriffspunkte für wirksame pharmakologische Interventionen zu identifizieren.\r\nDie wichtigsten Hypothesen, die es zu untersuchen gilt, sind, \r\n•\tdass Zellwandkomponenten des intestinalen Mikrobioms (Lipopolysaccharid, Pepidoglycan) und  intestinale Hormone unter dem Einfluss des Mikrobioms (Glucagon-Like Peptide, Peptid YY) depressive Verhaltensänderungen hervorrufen,\r\n•\tviszerale Immunaktivierung das affektive Verhalten kurz- und langfristig beeinflusst;\r\n•\tspezifische Signaltransduktionsmechanismen im Gehirn (Receptor-Activator of Nuclear Factor B Ligand, Cyclooxygenase-2 und Brain-Derived Neurotrophic Factor) von Relevanz für die affektiven Störungen im Gefolge einer peripheren Immunaktivierung sind, und\r\n•\tdepressive Verhaltensänderungen nach viszeraler Immunstimulierung mit einer Störung der Hypothalamus-Hypophysen-Nebennieren-Achse, einer Störung des Glukokortikoid-Feedback an das Gehirn und einer Störung der Neurogenese im limbischen System assoziiert sind.",
                "en": "Being one of the most prevalent and severe mood disorders, major depression is deleterious to the patients’ quality of life and of enormous socio-economic impact. According to the World Health Organization, depression is the second most frequent cause of disability-adjusted life years in the age category of 15 – 44 years for both genders, with the number of patients continuing to grow. A proportion of some 40 % of the patients does not satisfactorily respond to the available antidepressant drugs, which reflects the incomplete understanding of the aetiology of affective disorders. Apart from vulnerability and psychosocial factors, chronic immune challenge has emerged as a circumstance relevant to the pathogenesis of mood disorders. The cytokine hypothesis of depression holds that systemic inflammatory processes associated with elevated levels of circulating proinflammatory cytokines disturb several brain mechanisms that control anxiety, mood, stress resilience and cognition.\r\nVisceral immune activation and inflammation are associated with a variety of psychiatric abnormalities, and there is clinical evidence that constituents of the intestinal microbiome across a leaky mucosal barrier may be a factor underlying mood disorders. Preclinical evidence indicates that gastrointestinal infection and inflammation as well as intraperitoneal administration of bacterial lipopolysaccharide induce behavioural disturbances. The current research proposal sets out to specifically examine the visceral immune – brain axis in an innovative and comprehensive manner and to identify key mechanisms that are suitable for pharmacological modulation.\r\nThe main hypotheses to be addressed are that\r\n•\tfactors derived from the intestinal microbiome (lipopolysaccharide, pepidoglycan) or intestinal hormones under the regulatory influence of the microbiome (glucagon-like peptide, peptide YY) have an impact on the visceral immune – brain axis;\r\n•\tvisceral immune challenge has a short- and long-term impact on affective behaviour;\r\n•\tspecific brain signalling mechanisms involving receptor-activator of nuclear factor B ligand,  cyclooxygenase-2 and brain-derived neurotrophic factor play a role in the behavioural effects of peripheral immune challenge; and\r\n•\tactivation of the visceral immune – brain axis is associated with deranged activity of the hypothalamic-pituitary-adrenal axis, disturbed glucocorticoid feedback on the brain and altered neurogenesis in the limbic system."
            },
            "begin_planned": "2012-05-01T02:00:00+02:00",
            "begin_effective": "2012-09-01T02:00:00+02:00",
            "end_planned": "2015-04-30T02:00:00+02:00",
            "end_effective": "2015-08-31T02:00:00+02:00",
            "assignment": "2012-08-30T10:10:47+02:00",
            "program": 72,
            "subprogram": null,
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P 24618",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2957-71487-12",
                "2957-51529-12"
            ]
        },
        {
            "id": 3581,
            "title": {
                "de": "Kortikale Pathologie und periventrikuläre Läsionen bei Multipler Sklerose – Ausdruck identer pathophysiologischer Prozesse?",
                "en": "An MRI-study to investigate the pathophysiological link between cortical atrophy and periventricular lesions in multiple sclerosis"
            },
            "short": "MS-KORTEX",
            "url": null,
            "abstract": {
                "de": "Die Pathogenese kortikaler Läsionen sowie der Zusammenhang der verschiedenen degenerativen Prozesse im ZNS bei MS sind bis heute weitgehend unklar. Bisherige Studien zeigten, dass meningeale Entzündungen eine wichtige Rolle bei der Entstehung der kortikalen Pathologie spielen können. Aggregierte Lymphozyten und Antikörper (T- und B- Zellen) infiltrieren Meningen und perivaskuläre Bereiche und führen in weiterer Folge zu einer Progression der Erkrankung. Aus dieser Erkenntnis ergibt sich die Fragestellung, ob unmittelbar periventrikuläre (d.h. liquornahe) Marklagerläsionen mit der kortikalen Pathologie in MS in Zusammenhang stehen.Um diese Fragestellung zu untersuchen, sollen in einem interdisziplinären Forschungsprojekt der Universitätsklinik für Neurologie und der klinischen Abteilung für Neuroradiologie (Universitätsklinik für Radiologie) der Medizinischen Universität Graz existierende MRT-Daten einer unizentrischen prospektiven MS-Studie (n=170) analysiert werden. Die kortikale Pathologie wird anhand der Messung der kortikalen Dicke geschätzt. Periventrikuläre Läsionen der weißen Substanz werden halbautomatisiert segmentiert. Die MR-Parameter werden quantifiziert und mittels Korrelationsanalyse wird die Hypothese überprüft, ob verminderte kortikale Dicke (sogenanntes „cortical thinning“ als Ausdruck subpialer kortikaler Läsionen) mit einer Häufung periventrikulärer Läsionen korreliert. Eine Korrelation zwischen diesen MR-Parametern wäre möglicherweise ein Hinweis dafür, dass die Läsionsprogression in MS durch spezifische Faktoren in der zerebrospinalen Flüssigkeit beschleunigt beziehungsweise vielleicht sogar initiiert wird.",
                "en": null
            },
            "begin_planned": "2014-05-01T02:00:00+02:00",
            "begin_effective": "2014-03-01T01:00:00+01:00",
            "end_planned": "2014-11-01T01:00:00+01:00",
            "end_effective": "2015-08-31T02:00:00+02:00",
            "assignment": "2014-02-27T11:39:15+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14108,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 60744,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3581-60744-10",
                "3581-51882-11",
                "3581-50173-11"
            ]
        },
        {
            "id": 3039,
            "title": {
                "de": "Evidenzbasierte High-tech Akupunktur und integrative Lasermedizin für Prävention und frühzeitige Intervention bei chronischen Erkrankungen",
                "en": "Evidence-based high-tech acupuncture and integrative laser medicine for prevention and early intervention of chronic diseases"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2012-07-01T02:00:00+02:00",
            "begin_effective": "2012-09-01T02:00:00+02:00",
            "end_planned": "2015-06-30T02:00:00+02:00",
            "end_effective": "2015-08-31T02:00:00+02:00",
            "assignment": "2012-11-13T13:40:23+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14044,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                25,
                472
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2153,
            "title": {
                "de": "Prostaglandin Rezeptoren in der Therapie von Allergien",
                "en": "Prostaglandin Rezeptoren in der Therapie von Allergien"
            },
            "short": "PROSTAGLANDIN_FWF09",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-06-01T02:00:00+02:00",
            "begin_effective": "2010-09-15T02:00:00+02:00",
            "end_planned": "2013-05-31T02:00:00+02:00",
            "end_effective": "2015-09-14T02:00:00+02:00",
            "assignment": "2010-03-04T15:00:25+01:00",
            "program": 72,
            "subprogram": null,
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51756,
            "contact": 51756,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P22521",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2153-51756-10"
            ]
        },
        {
            "id": 2954,
            "title": {
                "de": "Genetik von Patienten_innen mit Fuchs‘scher Endotheldystrophie in einer österreichischen Population",
                "en": "Genetic investigation of Fuchs' endothelial corneal dystrophy in an Austrian population"
            },
            "short": "Genetik bei Fuchs’scher Endotheldystroph",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2012-11-01T01:00:00+01:00",
            "begin_effective": "2012-10-01T02:00:00+02:00",
            "end_planned": "2014-11-01T01:00:00+01:00",
            "end_effective": "2015-09-20T02:00:00+02:00",
            "assignment": "2012-08-29T10:24:13+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14043,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 65638,
            "contact": null,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135,
                938
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2954-65638-10"
            ]
        },
        {
            "id": 2615,
            "title": {
                "de": "Tailored biodegradable magnesium implant materials",
                "en": "Tailored biodegradable magnesium implant materials"
            },
            "short": "MagnIM",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-10-01T02:00:00+02:00",
            "begin_effective": "2011-10-01T02:00:00+02:00",
            "end_planned": "2014-09-30T02:00:00+02:00",
            "end_effective": "2015-09-30T02:00:00+02:00",
            "assignment": "2011-10-18T11:42:58+02:00",
            "program": 24,
            "subprogram": "Marie Curie Initial Training Network (ITN)",
            "organization": 14052,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 50785,
            "contact": 50785,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": "289163",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2615-50785-10"
            ]
        },
        {
            "id": 2608,
            "title": {
                "de": "Biphasischer PNA FISH Test zur antizipativen Diagnose von Zentralvenenkatheter-assoziierten Bakteriämien/Fungämien Projektnummer:832079",
                "en": "Anticipative Diagnosis of Catheter-related Bloodstream Infections with biphasic PNA-FISH"
            },
            "short": "CRBSI screening",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-08-01T02:00:00+02:00",
            "begin_effective": "2011-09-01T02:00:00+02:00",
            "end_planned": "2014-07-31T02:00:00+02:00",
            "end_effective": "2015-09-30T02:00:00+02:00",
            "assignment": "2011-10-06T12:20:10+02:00",
            "program": 60,
            "subprogram": null,
            "organization": 14087,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 51976,
            "contact": 51976,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                416
            ],
            "funder_projectcode": "832079 ",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2608-51976-10"
            ]
        },
        {
            "id": 3342,
            "title": {
                "de": "Klinisches Decision Support System (DSS) für molekulare Pathologie - Research Studios Austria - ProjektNr. 841246",
                "en": "Klinisches Decision Support System (DSS) für molekulare Pathologie"
            },
            "short": "kDSSMP",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2013-08-01T02:00:00+02:00",
            "begin_effective": "2013-08-01T02:00:00+02:00",
            "end_planned": "2015-07-31T02:00:00+02:00",
            "end_effective": "2015-09-30T02:00:00+02:00",
            "assignment": "2013-08-02T15:02:02+02:00",
            "program": 107,
            "subprogram": null,
            "organization": 14020,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 51663,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                416
            ],
            "funder_projectcode": "841246",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3342-51663-10"
            ]
        },
        {
            "id": 3455,
            "title": {
                "de": "Dyslexie und Strabismus: Vision und Perzeption",
                "en": "Dyslexie und Strabismus: Vision und Perzeption"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2013-09-01T02:00:00+02:00",
            "begin_effective": "2013-09-01T02:00:00+02:00",
            "end_planned": "2015-02-28T01:00:00+01:00",
            "end_effective": "2015-09-30T02:00:00+02:00",
            "assignment": "2013-12-03T12:45:45+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 77049,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3455-58883-11",
                "3455-77049-10"
            ]
        },
        {
            "id": 2618,
            "title": {
                "de": "Wirkung des neuen Lipidsenkers Niacin/Laropiprant (Tredaptive®) auf Funktion humaner Blutplättchen",
                "en": "Effect of the novel lipid-lowering therapy niacin plus laropiprant (Tredaptive®) on platelet function: Benefit or hazard?"
            },
            "short": "LIPIDSENKER NIACIN/LAROPIPRANT",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-10-01T02:00:00+02:00",
            "begin_effective": "2011-10-01T02:00:00+02:00",
            "end_planned": "2013-09-30T02:00:00+02:00",
            "end_effective": "2015-09-30T02:00:00+02:00",
            "assignment": "2011-10-19T13:21:31+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51756,
            "contact": 51756,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2618-51756-10"
            ]
        },
        {
            "id": 3782,
            "title": {
                "de": "Mitochondrien als neues Ziel in der Behandlung diverser Erkrankungen",
                "en": "Mitochondria- a novel target for treatment of many diseases"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2013-03-01T01:00:00+01:00",
            "begin_effective": "2014-10-01T02:00:00+02:00",
            "end_planned": "2014-09-30T02:00:00+02:00",
            "end_effective": "2015-09-30T02:00:00+02:00",
            "assignment": "2014-10-07T15:55:58+02:00",
            "program": null,
            "subprogram": null,
            "organization": 28392,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2697,
            "title": {
                "de": "Herzinsuffizienzforschung an der Medizinischen Universität Graz",
                "en": "Herzinsuffizienzforschung an der Medizinischen Universität Graz"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-10-01T02:00:00+02:00",
            "begin_effective": "2011-10-01T02:00:00+02:00",
            "end_planned": "2015-09-30T02:00:00+02:00",
            "end_effective": "2015-09-30T02:00:00+02:00",
            "assignment": "2011-12-19T10:48:05+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2697-58906-12",
                "2697-60041-12",
                "2697-60377-12",
                "2697-60390-12",
                "2697-62075-12",
                "2697-62747-12",
                "2697-59941-12",
                "2697-75758-12",
                "2697-78591-12",
                "2697-83082-12",
                "2697-89052-12"
            ]
        },
        {
            "id": 2538,
            "title": {
                "de": "Expression und Funktion von Prostaglandin D2 Rezeptoren bei allergischen und asthmatischen Erkrankungen",
                "en": "Enhanced expression and function of prostaglandin D2 receptors in monocytes, macrophages and eosinophils of patients with allergy and bronchial asthma"
            },
            "short": "PGD2 receptors in allergic and asthmatic",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-10-01T02:00:00+02:00",
            "begin_effective": "2011-10-01T02:00:00+02:00",
            "end_planned": "2013-09-30T02:00:00+02:00",
            "end_effective": "2015-09-30T02:00:00+02:00",
            "assignment": "2011-07-19T12:42:10+02:00",
            "program": 79,
            "subprogram": null,
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50791,
            "contact": 50791,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2538-50791-10"
            ]
        },
        {
            "id": 2970,
            "title": {
                "de": "DK \"Molecular Fundamentals of Inflammation\"",
                "en": "DK \"Molecular Fundamentals of Inflammation\""
            },
            "short": "DK-MOLIN",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2012-03-01T01:00:00+01:00",
            "begin_effective": "2012-10-01T02:00:00+02:00",
            "end_planned": "2016-02-28T01:00:00+01:00",
            "end_effective": "2015-09-30T02:00:00+02:00",
            "assignment": "2012-09-06T13:03:09+02:00",
            "program": 66,
            "subprogram": null,
            "organization": 14080,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 51809,
            "contact": 51809,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "W1241",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2970-51809-10"
            ]
        },
        {
            "id": 2911,
            "title": {
                "de": "Psoriasis, dysfunktionales HDL und koronare Herzkrankheit ",
                "en": "Psoriasis, dysfunctional HDL und coronary artery disease"
            },
            "short": "Psoriasis verände3rt gutes Cholesterin",
            "url": null,
            "abstract": {
                "de": "Psoriasis, dysfunktionales HDL und koronare Herzkrankheit \r\n\r\nPsorias, eine chronisch entzündliche Hautererkrankung, betrifft etwa 3% der Menschen weltweit. Psoriasis ist ein eigenständiger erheblicher Risikofaktor für arterielle Erkrankungen des Herz-Kreislauf-Systems, die Ursachen für den beobachteten Zusammenhang sind jedoch unklar. In diesem Projektantrag soll untersucht  werden, ob Psoriasis mit einer funktionellen Beeinträchtigung des high-density lipoproteins (HDL) assoziiert ist. Unter physiologischen Bedingungen vermittelt anti-atherogenes HDL den reversen Cholesterintransport und wirkt vaskuloprotektiv. Mittels massenspektroskopischen und biochemischen Analysen sollen Veränderungen im Proteom und in der Lipidzusammensetzung des HDL von Psoriasis Patienten im Vergleich zu gesunden Kontrollen untersucht werden. In weiterer Folge soll untersucht werden, ob eine veränderte HDL-Zusammensetzung mit einer funktionellen Beeinträchtigung des HDL-Partikels einhergeht. \r\n",
                "en": "Psoriasis, a very common skin disease, is nowadays considered as a systemic inflammatory condition. Psoriasis patients harbor an increased risk of myocardial infarction and stroke, and numerous studies indicate that psoriasis and cardiovascular disease - particularly atherosclerosis - share common pathogenic features. \r\nPatients with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis have decreased levels of high-density lipoprotein (HDL), suggesting that HDL may be important in preventing autoimmunity and the loss of self-tolerance. Proposed mechanisms for the atheroprotective functions of HDL include reverse cholesterol transport, reduction of oxidative stress and potent anti-inflammatory effects. On the other hand, HDL was shown to lose its-anti-atherogenic properties by post-translational modifications such as oxidation and carbamylation. There is emerging evidence suggesting that anti-atherogenic activities of HDL cannot be described by its plasma concentrations alone. For example, cholesterol efflux capacity, a functional measure of HDL, has an inverse association with the likelihood of coronary artery disease independent of HDL-cholesterol levels. Recent studies that elucidated the proteome of HDL from healthy individuals and patients with coronary artery disease or renal disease by mass spectrometry revealed that the protein cargo is a major determinant of the anti-atherogenic and anti-inflammatory properties of HDL. As qualitative alterations of HDL seem to be directly linked with increased cardiovascular complications, we hypothesize that HDL from psoriatic patients might display defective cholesterol efflux capability and anti-oxidative activities. \r\n"
            },
            "begin_planned": "2012-10-01T02:00:00+02:00",
            "begin_effective": "2013-04-01T02:00:00+02:00",
            "end_planned": "2014-09-30T02:00:00+02:00",
            "end_effective": "2015-09-30T02:00:00+02:00",
            "assignment": "2012-07-06T12:57:50+02:00",
            "program": 79,
            "subprogram": null,
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 53252,
            "contact": 53252,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2911-53252-10"
            ]
        },
        {
            "id": 3721,
            "title": {
                "de": "Disseminierende Tumorzellen in primär metastasierten Brustkrebspatientinnen mit Chirurgie des Primärtumors  ",
                "en": "Disseminating tumor cells in primary metastasized breast cancer patients undergoing surgery of primary tumor"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2014-10-01T02:00:00+02:00",
            "begin_effective": "2014-10-01T02:00:00+02:00",
            "end_planned": "2015-09-30T02:00:00+02:00",
            "end_effective": "2015-09-30T02:00:00+02:00",
            "assignment": "2014-07-23T16:36:55+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14085,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 80692,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                122
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3721-80692-10"
            ]
        },
        {
            "id": 3751,
            "title": {
                "de": "Der Anstieg des pulmonalen Blutflusses nach der Geburt.",
                "en": "Understanding the increase in pulmonary blood flow at birth."
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2014-10-01T02:00:00+02:00",
            "begin_effective": "2014-10-01T02:00:00+02:00",
            "end_planned": "2015-09-30T02:00:00+02:00",
            "end_effective": "2015-09-30T02:00:00+02:00",
            "assignment": "2014-08-20T11:39:49+02:00",
            "program": 69,
            "subprogram": null,
            "organization": 14094,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 73733,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "J3595",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3751-73733-10"
            ]
        },
        {
            "id": 3855,
            "title": {
                "de": "Kardiovaskuläre Risikofaktoren bei Patienten mit Depression",
                "en": "Cardiovascular risk factors in patients with major depression"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2014-07-01T02:00:00+02:00",
            "begin_effective": "2014-07-01T02:00:00+02:00",
            "end_planned": "2015-07-01T02:00:00+02:00",
            "end_effective": "2015-10-01T02:00:00+02:00",
            "assignment": "2015-01-14T13:01:15+01:00",
            "program": null,
            "subprogram": null,
            "organization": 29444,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50662,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3855-50662-10"
            ]
        },
        {
            "id": 3688,
            "title": {
                "de": "Gelber LASER - Eine neue Option in der präventiven Grazer Gesundheitsforschung?",
                "en": "Yellow LASER - A new option in the preventive Graz health research?"
            },
            "short": "Gelber LASER",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2014-07-01T02:00:00+02:00",
            "begin_effective": "2014-07-01T02:00:00+02:00",
            "end_planned": "2015-06-30T02:00:00+02:00",
            "end_effective": "2015-10-01T02:00:00+02:00",
            "assignment": "2014-06-23T10:43:27+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14044,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 3674,
            "title": {
                "de": "Die Rolle des Orai N-Terminus und des 2. Loops in der Kopplung mit STIM1",
                "en": "The role of Orai N-terminus and loop 2 in the coupling with STIM1"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2012-10-08T02:00:00+02:00",
            "begin_effective": "2012-10-08T02:00:00+02:00",
            "end_planned": "2015-10-07T02:00:00+02:00",
            "end_effective": "2015-10-07T02:00:00+02:00",
            "assignment": "2014-05-27T16:39:36+02:00",
            "program": 72,
            "subprogram": "Nachmeldung zu einem Projekt, dass bereits vorweg an den FWF weitergeleitet wurde und bewilligt wurde.",
            "organization": 14011,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 78591,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P 25172",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3674-78591-10"
            ]
        }
    ]
}