Project List
List projects.
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id (integer)
Primary key.
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The following relational fields can be expanded:
organizationcategorytypepartner_functionmanagercontactstatusgrantresearcheventstudylanguageprogramfunders
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begin_planned:gt,gte,lt,ltebegin_effective:gt,gte,lt,lteend_planned:gt,gte,lt,lteend_effective:gt,gte,lt,lte
GET /v1/research/project/?format=api&offset=740&ordering=-end_planned
{ "count": 2139, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=760&ordering=-end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=720&ordering=-end_planned", "results": [ { "id": 5896, "title": { "de": "Biobanking und Human Genom Projekt Zyperns", "en": "BIOBANKING AND THE CYPRUS HUMAN GENOME PROJECT \r\n(TEAMING)" }, "short": "CY-Biobank", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-05-01T02:00:00+02:00", "begin_effective": "2019-10-01T02:00:00+02:00", "end_planned": "2022-11-30T01:00:00+01:00", "end_effective": "2027-09-30T02:00:00+02:00", "assignment": "2019-08-28T10:58:25+02:00", "program": 109, "subprogram": null, "organization": 28392, "category": 10, "type": 10, "partner_function": 2, "manager": 54033, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "857122", "ethics_committee": null, "edudract_number": null, "persons": [ "5896-54033-10", "5896-59323-12", "5896-105319-12" ] }, { "id": 4195, "title": { "de": "Translationale Ansätze für eine kausale Therapie bei Typ 1 Diabetes: Ein innovativer Zugang zum Verständnis und Heilung von Typ 1 Diabetes", "en": "Translational approaches to disease modifying therapy of type 1 diabetes: An innovative approach towards understanding and arresting Type 1 diabetes" }, "short": "INNODIA_Horizon", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-11-01T01:00:00+01:00", "begin_effective": "2015-11-01T01:00:00+01:00", "end_planned": "2022-10-31T01:00:00+01:00", "end_effective": "2023-10-31T01:00:00+01:00", "assignment": "2015-12-15T12:09:23+01:00", "program": 109, "subprogram": "IMI2", "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "115797", "ethics_committee": null, "edudract_number": null, "persons": [ "4195-51831-10", "4195-50452-12", "4195-50659-11", "4195-62036-11", "4195-67348-12", "4195-95211-12", "4195-81132-12" ] }, { "id": 6238, "title": { "de": "Effekte von HDAC Inhibition auf die kontraktile Funktion und Stoffwechsel in Herzinsuffizienz mit erhaltener Pumpfunktion", "en": "Effects of HDAC inhibition on contractile function and metabolism in heart failure with preserved ejection fraction" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-10-01T02:00:00+02:00", "begin_effective": "2020-10-01T02:00:00+02:00", "end_planned": "2022-10-31T01:00:00+01:00", "end_effective": "2025-10-31T01:00:00+01:00", "assignment": "2020-08-11T16:12:28+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 72301, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 468 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6238-72301-10", "6238-75758-12", "6238-110289-12" ] }, { "id": 7051, "title": { "de": "Die Welt in 2050", "en": "The World in 2050" }, "short": "World 2050", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-11-01T01:00:00+01:00", "begin_effective": "2022-06-01T02:00:00+02:00", "end_planned": "2022-10-31T01:00:00+01:00", "end_effective": "2024-03-31T01:00:00+01:00", "assignment": "2022-06-09T11:03:37+02:00", "program": null, "subprogram": null, "organization": 23612, "category": 10, "type": 10, "partner_function": 1, "manager": 54033, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": "00000409", "ethics_committee": null, "edudract_number": null, "persons": [ "7051-54033-10" ] }, { "id": 6510, "title": { "de": "Identifizierung von Antigen-spezifischen T-Zellen über Ca2+ - NFAT-Aktivierung bei Lungenkrebs", "en": "Identification of antigen-specific T cells via Ca2+ - NFAT signaling in non-small cell lung cancer" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-04-01T02:00:00+02:00", "begin_effective": "2021-04-01T02:00:00+02:00", "end_planned": "2022-10-31T01:00:00+01:00", "end_effective": "2022-10-31T01:00:00+01:00", "assignment": "2021-03-30T10:44:48+02:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 60706, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-60", "ethics_committee": null, "edudract_number": null, "persons": [ "6510-60706-10" ] }, { "id": 7059, "title": { "de": "Erforschung neuer Anti-Aging Strategien", "en": "Investigating novel anti-aging strategies " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-06-01T02:00:00+02:00", "begin_effective": "2022-06-01T02:00:00+02:00", "end_planned": "2022-10-30T02:00:00+02:00", "end_effective": "2022-12-31T01:00:00+01:00", "assignment": "2022-06-15T10:55:31+02:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 85069, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7059-85069-10" ] }, { "id": 6055, "title": { "de": "COST: Internationales Netzwerk für translationale Forschung an perinatalen Derivaten für therapeutische Applikationen", "en": "COST: International Network for Translating Research on Perinatal Derivatives into Therapeutic Approaches" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-16T02:00:00+02:00", "begin_effective": "2018-10-16T02:00:00+02:00", "end_planned": "2022-10-15T02:00:00+02:00", "end_effective": "2022-10-15T02:00:00+02:00", "assignment": "2020-02-12T16:36:06+01:00", "program": 22, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 51718, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6055-51718-10" ] }, { "id": 6306, "title": { "de": "SARS-CoV-2 infection in HIV-positive patients with or without antiretroviral therapy in sub-Saharan Africa", "en": "SARS-CoV-2 infection in HIV-positive patients with or without antiretroviral therapy in sub-Saharan Africa (EDCTP PROJECT)" }, "short": "EDCTP PROJECT (HIV AND COVID-19)", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-10-10T02:00:00+02:00", "begin_effective": "2020-09-01T02:00:00+02:00", "end_planned": "2022-10-09T02:00:00+02:00", "end_effective": "2023-12-31T01:00:00+01:00", "assignment": "2020-10-12T17:25:58+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 3, "manager": 57932, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2551 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6306-57932-10" ] }, { "id": 6296, "title": { "de": "Transport lebender 3D Zellkulturen mittels Biochip", "en": "Transport of living 3D cell cultures by biochip" }, "short": "TransCell", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-09-01T02:00:00+02:00", "begin_effective": "2020-09-01T02:00:00+02:00", "end_planned": "2022-10-03T02:00:00+02:00", "end_effective": "2023-08-31T02:00:00+02:00", "assignment": "2020-10-05T19:06:58+02:00", "program": null, "subprogram": null, "organization": 27477, "category": 10, "type": 10, "partner_function": 3, "manager": 50826, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "880628", "ethics_committee": null, "edudract_number": null, "persons": [ "6296-50826-10", "6296-112109-12", "6296-113936-12", "6296-106294-12", "6296-109142-12" ] }, { "id": 6488, "title": { "de": "Umwidmung von Xenobiotika-Rezeptor Liganden fuer die Behandlung von A1AT Mangel", "en": "Repurposing of xenobiotic receptor ligands to treat A1AT deficient liver disease" }, "short": "drug repurposing", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-03-01T01:00:00+01:00", "begin_effective": "2021-03-01T01:00:00+01:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2024-09-30T02:00:00+02:00", "assignment": "2021-03-10T11:43:57+01:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 50593, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-62", "ethics_committee": null, "edudract_number": null, "persons": [ "6488-50593-10" ] }, { "id": 6070, "title": { "de": "Kalzium Detektion von STIM1/STIM2 reguliert Ca2+ Signale", "en": "Ca2+ sensing of STIM1/2 shapes physiological Ca2+ signals" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-10-01T02:00:00+02:00", "begin_effective": "2020-01-06T01:00:00+01:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2020-02-26T14:53:02+01:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 98848, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P32778", "ethics_committee": null, "edudract_number": null, "persons": [ "6070-98848-10" ] }, { "id": 5484, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Inflammatory Disorders in Pregnancy\r\n\r\n" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:33:55+02:00", "program": 114, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 51632, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5484-51632-10", "5484-68413-12", "5484-59816-12", "5484-100826-12", "5484-100803-12", "5484-95608-12", "5484-109041-12" ] }, { "id": 6841, "title": { "de": "Der Effekt von Hydroxychloroquin auf Plazentafunktion bei Frauen mit Präeklampsie", "en": "Effect of hydroxychloroquine on human placental function in severe preeclampsia" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2021-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2021-12-15T16:30:47+01:00", "program": 114, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "DOC 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5867, "title": { "de": "Mitochondrien als potenzielle Ziele in der Therapie gegen Krebs und Zellalterung", "en": "Mitochondria as potential targets in cancer and cell aging therapy" }, "short": "MitoAge", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-10-01T02:00:00+02:00", "begin_effective": "2019-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2019-07-17T16:25:58+02:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51860, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-45", "ethics_committee": null, "edudract_number": null, "persons": [ "5867-51860-10" ] }, { "id": 5480, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft.\r\nNuclear Rezeptor - vermittelte Regulation metabolischer und inflammatorischer Mediatoren in fetoplazentaren Endothelzellen", "en": "Inflammatory Disorders in Pregnancy.\r\nNuclear receptors regulating metabolism and inflammatory mediators in fetoplacental endothelial cells" }, "short": "DP-iDP", "url": "https://www.medunigraz.at/phd-inflammatory-disorders-in-pregnancy/", "abstract": { "de": null, "en": "Rising evidence suggests that Gestational diabetes mellitus (GDM) modulates the placental endothelium to an altered metabolic state causing vascular dysfunction and altered fetal programming. GDM is associated with oxidative stress which may contribute to endothelial dysfunction. Oxysterols, generated from cholesterol oxidation either by CYP-450 reductase or by reactive oxygen species (ROS), are endogenous activators of liver-X receptors (LXRs), nuclear transcription factors centrally involved in important biological processes, including lipid/cholesterol and glucose metabolism (1). \r\nLXRs promote high-density lipoprotein (HDL) formation by activating several target genes of reverse cholesterol transport. We earlier reported that LXR target genes (ABCA1, ABCG1 and PLTP) are centrally involved in HDL mediated cholesterol efflux from fetoplacental endothelial cells (HPEC) (2-4). \r\nA current focus of our laboratory is to define the impact of oxysterols and pharmacological activators of LXRs on cholesterol-metabolic and inflammatory functions in the GDM feto-placental vasculature. Unpublished results of our group strongly suggest that the GDM environment modulates cholesterol homeostasis by enhancing cholesterol biosynthesis and cholesterol efflux in fetoplacental endothelial cells while cellular cholesterol homeostasis is largely maintained. Thus, GDM may affect placental cholesterol metabolism via LXR activation due to increased oxysterol levels in cells and/or in the fetal circulation. \r\nWhile HDL itself exerts anti-inflammatory actions on endothelial cells, LXRs are also involved in immune regulatory functions and can reduce inflammation by sumoylation-dependent and -independent mechanisms (1). Upon activation, LXRs can be sumoylated and as a monomer can stabilize repressor complexes present on the promoter sequence of proinflammatory pathways such as activator protein 1 (AP-1) and nuclear factor kB (NF-kB), thereby preventing the expression of proinflammatory factors. In brain endothelial cells, LXR activation by oxysterols or synthetic agonist TO901317 significantly reduced expression of inflammatory genes COX-II and TNF along with modulating cellular cholesterol metabolism (5). We hypothesize that endogenous and/or pharmacologic activation of LXRs may improve fetoplacental endothelial function in conditions of GDM and other pregnancy complications related to metabolic diseases.\r\n\r\nReferences:\r\n1.\tGuillemot-Legris O, Mutemberezi V, Muccioli GG. Oxysterols in Metabolic Syndrome: From Bystander Molecules to Bioactive Lipids. Trends Mol Med. 2016; 22(7):594-614.\r\n2.\tStefulj J, Panzenboeck U1, Becker T, Hirschmugl B, Schweinzer C, Lang I, Marsche G, Sadjak A, Lang U, Desoye G, and Wadsack C. Human Endothelial Cells of the Placental Barrier Efficiently Deliver Cholesterol to the Fetal Circulation via ABCA1 and ABCG1. Circ Res. 2009; 104:600-608.\r\n4.\tScholler M, Wadsack C, Metso J, Chirackal Manavalan AP, Sreckovic I, Schweinzer C, Hiden U, Jauhiainen M, Desoye G, Panzenboeck U. Phospholipid transfer protein is differentially expressed in human arterial and venous placental endothelial cells and enhances cholesterol efflux to fetal HDL. J Clin Endocrinol Metab. 2012; 97:2466-74.\r\n5.\tScholler M, Wadsack C, Lang I, Etschmaier K, Schweinzer C, Marsche G, Dieber-Rotheneder M, Desoye G, Panzenboeck U. Phospholipid Transfer Protein in the Placental Endothelium Is Affected by Gestational Diabetes Mellitus. J Clin Endocrinol Metab. 2012; 97:437-45.\r\n7.\tSchweinzer C, Kober A, Lang I, Etschmaier K, Scholler M, Kresse A, Sattler W, Panzenboeck U. Processing of Endogenous AβPP in Blood-Brain Barrier Endothelial Cells is Modulated by Liver-X Receptor Agonists and Altered Cellular Cholesterol Homeostasis. J Alzheimers Dis. 2011; 27(2):341-360.\r\n" }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:18:44+02:00", "program": 114, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 50442, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5480-50442-10", "5480-61645-12", "5480-100968-12" ] }, { "id": 5483, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Inflammatory Disorders in Pregnancy" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:32:58+02:00", "program": 114, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 2, "manager": 53252, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5483-53252-10" ] }, { "id": 6272, "title": { "de": "Rechtsventrikel Echokardiographie und Neuropathie Assessment zur besseren Identifikation von Patient*innen mit Amyloidose", "en": "Advanced right ventricular echocardiography and assessment of neuropathy to identify patients with cardiac amyloidosis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-10-01T02:00:00+02:00", "begin_effective": "2020-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2024-06-30T02:00:00+02:00", "assignment": "2020-09-14T11:09:23+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 81519, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 468 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6272-81519-10" ] }, { "id": 5479, "title": { "de": " Inflammatorische Erkrankungen in der Schwangerschaft ", "en": "Inflammatory Disorders in Pregnancy " }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:17:36+02:00", "program": 114, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 100455, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5479-100455-10" ] }, { "id": 6517, "title": { "de": "Mechanismen der Humanen Diabetischen Kardiomyopathie", "en": "Mechanisms of Human Diabetic Cardiomyopathy" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-01-04T01:00:00+01:00", "begin_effective": "2021-01-04T01:00:00+01:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2021-04-07T12:19:57+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 1, "manager": 105266, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1886 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6517-105266-10" ] }, { "id": 5972, "title": { "de": "Network of Health Science Innovation Incubation\r\nPrograms - ERASMUS, KA203", "en": "Network of Health Science Innovation Incubation\r\nPrograms - ERASMUS" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-10-01T02:00:00+02:00", "begin_effective": "2019-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2019-12-03T18:04:09+01:00", "program": null, "subprogram": null, "organization": 23646, "category": 10, "type": 10, "partner_function": 4, "manager": 56582, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5972-56582-10" ] } ] }