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GET /v1/research/project/?format=api&offset=680&ordering=begin_planned
{ "count": 2139, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=700&ordering=begin_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=660&ordering=begin_planned", "results": [ { "id": 3321, "title": { "de": "Hormonale Regulation der Lipolyse", "en": "Hormonal regulation of lipolysis" }, "short": "Hormonal regulation of lipolysis", "url": null, "abstract": { "de": "Lipasen, das sind Fett spaltende Enzyme, spielen eine wichtige Rolle im Energiestoffwechsel. Beeinträchtigungen ihrer Funktion verursachen Störungen in der Aufnahme, in der Mobilisierung und im Transport von Fetten, sog. Lipiden, und führen zu Lipid-assoziierten Krankheiten, z.B. Typ 2 Diabetes, Atherosklerose und Leberkrankheiten, aber auch Krebs. Die Kontrolle der Lipolyse ist wichtig für das Gleichgewicht des Energiehaushalts und die Verteilung der Fettdepots im Körper. Die Freisetzung von Fettsäuren ist abhängig von der Lipolyse von Triacylglyzeriden und wird neural und hormonal reguliert, um den Energiebedarf zu stillen. Die molekularen Mechanismen dieser Regulation sind noch nicht vollständig erforscht, aber posttranslationelle Proteinmodifikationen, Proteininteraktionen, Proteinlokalisierung und Zugang der Lipasen zu ihrem Substraten, den Lipiden, scheinen eine große Rolle zu spielen. Phosphorylierung der Hormonsensitiven Lipase, des Perilipins und der Adipose Triglyzerid Lipase wurde an verschiedenen Stellen durch verschiedene Kinasen beschrieben. Die Regulation und Funktion der Phosphorylierungsstellen wird aber ungenügend verstanden. Auch ist nichts über die Regulation anderer wichtiger Lipasen und Regulatoren, wie der Monoglyzerid Lipase, CGI-58 und G0/G1 Switch Gen 2, bekannt.\r\nWir haben eine analytische Plattform zur Detektion, vergleichenden Analyse und Visualisierung von Lipasen in lebenden Zellen und Geweben etabliert. In unseren Studien haben wir wiederholt Proteinisoformen der Lipasen detektiert. Außerdem haben wir kürzlich entdeckt, dass CGI-58 phosphoryliert wird. Zusammenfassend weisen unsere Studien, sowie die Studien anderer, auf die Existenz von Lipolyseproteinkomplexen hin, die über Phosphorylierung reguliert werden. Ziel des Projekts ist es daher, die Regulation des Lipidgleichgewichts besser zu verstehen. Dazu werden wir untersuchen, ob Lipasen und ihre Regulatoren phosphoryliert werden, ob und wie Lipolyseproteinkomplexe im Fettgewebe hormonell reguliert werden, und welche Funktionen neue Phosphorylierungsstellen und Proteininteraktionspartner von Lipasen und Regulatoren haben. Dadurch wird auch zum ersten Mal das lipolytische Proteom in humanen Fettgewebe direkt auf der Enzymaktivitätsebene erschlossen, was zum besseren Verständnis der Lipid-Mobilisierung in gesundem Gewebe führen wird, und so neue Therapieansätze für Lipid-assoziierte Krankheiten eröffnen wird.\r\n\r\n", "en": "Lipases play a key role in regulation of whole body energy homeostasis. Control of lipolysis is important for energy partitioning and balance and maintains the size of fat depots in the body. Dysregulation of lipolytic activities affects lipid absorption, mobilization and transport, and is causative for lipid-related diseases. The release of free fatty acids is dependent on the lipolysis of stored triacylglycerol which is tightly controlled by neural regulation and several hormones to meet energy demands. Molecular mechanisms of this regulation are poorly understood but post-translational modification, protein interactions, protein localizations and access of lipases to their substrates appear to play a major role. Phosphorylation of hormone sensitive lipase, the lipolysis regulator perilipin 1 and more recently also adipose triglyceride lipase (ATGL) have been described on various sometimes controversial sites by different sometimes unknown kinases. Regulations and functions of described sites, however, are poorly understood. Moreover, no information is yet available on regulation of other important players, such as monoglyceride lipase or the ATGL regulators comparative gene identification 58 (CGI-58/ABHD-5) and G0/G1 switch gene 2.\r\nWe have established an analytical platform for activity-based discovery, detection, profiling and imaging of lipolytic enzymes in intact cells and tissues. In our activity-based proteomic screens we have repeatedly detected active isoforms of lipases suggesting that they are posttranslationally modified. Moreover, we have recently discovered a novel post translational modification of CGI-58 by protein kinase A. Previous work by others and us points thus towards the existence of lipolytic complexes and post translational modification of the involved proteins, warranting a comprehensive screen for novel regulators of lipolysis.\r\nThe major objective of the proposed project Hormonal regulation of lipolysis is to provide a better understanding of the regulation of lipid homeostasis. We will perform in vitro kinase assays to search for novel substrates of known kinases among known lipolytic proteins and protein regulators, investigate the (phospho)proteomic effects of hormonal regulation on lipolytic complexes in murine and human tissues, and functionally analyze selected novel potential regulators of lipolysis (i.e. novel phosphosites, including our novel CGI-58 phosphosite, and/or novel interacting proteins).\r\nAlthough many protein functions appear to be conserved in humans and mice there is growing evidence for important interspecies differences, especially in complex diseases caused by genetic and environmental factors, which cannot be easily reproduced in model organisms. While activity-based probes were already successfully employed to identify novel lipolytic enzymes in mouse liver and adipose tissue homogenates, this study will for the first time shed light on the lipolytic proteome of human adipose tissues in situ directly at enzymatic activity level. Combined with standard quantitative (phospho)proteomic profiling relevant regulators of lipolytic activities will be identified and might offer entry points for future therapies.\r\n\r\n\r\n" }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2016-07-31T02:00:00+02:00", "end_effective": "2016-08-31T02:00:00+02:00", "assignment": "2013-07-10T10:40:38+02:00", "program": 72, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 58794, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P26074", "ethics_committee": null, "edudract_number": null, "persons": [ "3321-58794-10", "3321-96765-12" ] }, { "id": 3342, "title": { "de": "Klinisches Decision Support System (DSS) für molekulare Pathologie - Research Studios Austria - ProjektNr. 841246", "en": "Klinisches Decision Support System (DSS) für molekulare Pathologie" }, "short": "kDSSMP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2015-07-31T02:00:00+02:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2013-08-02T15:02:02+02:00", "program": 107, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 3, "manager": 51663, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "841246", "ethics_committee": null, "edudract_number": null, "persons": [ "3342-51663-10" ] }, { "id": 3350, "title": { "de": "Etablierung eines in-vitro Modells zur Stimmlippenvernarbung", "en": "Establishment of an in-vitro model for vocal fold scarring" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2014-07-31T02:00:00+02:00", "end_effective": "2014-06-30T02:00:00+02:00", "assignment": "2013-08-14T11:38:53+02:00", "program": null, "subprogram": null, "organization": 14068, "category": 10, "type": 10, "partner_function": 4, "manager": 50670, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3350-50670-10", "3350-50464-12", "3350-50562-12" ] }, { "id": 3327, "title": { "de": "Bedeutung von Autophagy in chronischer Cholestase und mögliche Modulierung durch Kernrezeptoren", "en": "Role of autophagy in chronic cholestasis in humans and its modulation by nuclear receptors" }, "short": "Autophagy and Cholestasis", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2015-07-31T02:00:00+02:00", "end_effective": "2015-12-31T01:00:00+01:00", "assignment": "2013-07-12T10:53:15+02:00", "program": 79, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 57377, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3327-50593-12", "3327-57377-10" ] }, { "id": 3264, "title": { "de": "Molekulare Mechanismen in der frühen Entwicklung von dendritischen Zellen", "en": "Regulatory mechanisms in early dendritic cell development" }, "short": null, "url": null, "abstract": { "de": null, "en": "Dendritic cells (DCs) are essential immune cells for antigen presentation and are responsible for the initiation of T-cell responses. With the exception of Langerhans cells, all subtypes of DCs are derived from bone marrow-resident hematopoietic stem cells (HSCs). DCs develop from HSCs via several specification steps and intermediate progenitor stages including common myeloid progenitor (CMP) and the monocyte/DC progenitor (MDPs) stages. \r\nThe transcription factor C/EBPa (CCAAT/enhancer binding protein alpha) is known to play an important role in early hematopoiesis. Mice with a homozygous deletion of the Cebpa gene have normal to elevated numbers of CMPs but completely lack granulocytic/monocytic progenitors (GMPs) and all subsequent granulocytic stages indicating that C/EBPa is essential for transition of early myeloid to late myeloid progenitors. Despite its critical role in early myeloid and hence DC progenitors little is known about C/EBPa in early DC development. \r\nPreliminary results from our lab using an inducible bone marrow-specific Cebpa knock-out mouse model (Mx1-Cre CebpaF/F) suggest that C/EBPa indeed has an important role in early DC development. Mice lacking Cebpa in the bone marrow display reduced numbers of both subtypes of conventional DCs (cDCs) in spleen, and even more prominent in lymph nodes and thymus, while plasmacytoid DCs are not affected. The fact that cDCs are formed albeit at reduced numbers indicates that C/EBPa is dispensable for cDC formation but is crucially involved in proliferation and/or inhibition of apoptosis in cDC precursors. In addition, it is currently not known whether cDCs formed in the absence of C/EBPa display full functional activity. Using gene expression profiling we have identified a number of C/EBPa target genes in early DC progenitors including other transcription factors, inflammatory cytokines, genes of the NF-kB-pathway, genes associated with DC maturation and distinct anti-apoptotic factors. Based on these results the aim of this project is to identify critical factors involved in differentiation, proliferation and/or inhibition of apoptosis in early DC progenitors affected by C/EBPa. To experimentally approach this goal we will use Mx1-Cre CebpaF/F experimental and Mx1-Cre Cebpawt/wt control mice and analyze DCs in spleen, lymph nodes and thymus for expression of various DC-specific surface antigens and - after isolation characterize their function. In addition, isolated FLT3+ myeloid progenitors of these mice will be stimulated with FLT3L and monitored in vitro for changes in gene expression and functionality at critical steps during DC formation. \r\n" }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2015-07-31T02:00:00+02:00", "end_effective": "2020-06-30T02:00:00+02:00", "assignment": "2013-05-08T09:53:08+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51911, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3264-51911-10", "3264-103865-12", "3264-94653-12" ] }, { "id": 3338, "title": { "de": "Rolle von Tumorstammzell-assoziierten non-coding RNAs beim hepatozellulären Karzinom", "en": "Role of stem cell-associated non-coding RNAs in hepatocellular carcinoma" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2013-07-18T16:36:18+02:00", "program": 81, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 53557, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 52 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3338-53557-10" ] }, { "id": 3376, "title": { "de": "Netzwerk für Innovation, Transfer und Verwertung von Medizinprodukten", "en": "Dynamic Network Arranged for Medical Device Innovation, Transfer & Exploitation" }, "short": "DYNAMITE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2015-12-31T01:00:00+01:00", "assignment": "2013-09-18T13:27:30+02:00", "program": 104, "subprogram": "Kooperation und Netzwerke", "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "840131", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3356, "title": { "de": "Elterlicher Stress bei Frühgeburt und pränatale Vorbereitung", "en": "Stress in parents of preterm infants and preparation of preterm birth" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2014-08-31T02:00:00+02:00", "end_effective": "2014-08-31T02:00:00+02:00", "assignment": "2013-08-21T16:06:03+02:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 50907, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3356-50907-10" ] }, { "id": 3455, "title": { "de": "Dyslexie und Strabismus: Vision und Perzeption", "en": "Dyslexie und Strabismus: Vision und Perzeption" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2015-02-28T01:00:00+01:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2013-12-03T12:45:45+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 77049, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3455-58883-11", "3455-51583-11", "3455-77049-10" ] }, { "id": 3325, "title": { "de": "Neue Biomarker für die Voraussage der Wirkung von Krebsmedikamenten bei Dickdarmkrebs [Charakterisierung von neuen prädiktiven Biomarkern bei Kolorektalkarzinom]", "en": "Characterization of novel predictive biomarkers in colorectal cancer patients treated with EGFR-targeting therapies" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2016-08-30T02:00:00+02:00", "end_effective": "2017-04-30T02:00:00+02:00", "assignment": "2013-07-10T15:42:33+02:00", "program": 79, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 58814, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3325-58814-10", "3325-53557-12" ] }, { "id": 3483, "title": { "de": "Systembiologie zur Identifizierung neuer Targets in der Therapie von Gefässerkrankungen", "en": "Systems Biology to Identify Molecular Targets for Vascular Disease Treatment" }, "short": "SysVasc", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2014-02-01T01:00:00+01:00", "end_planned": "2018-09-01T02:00:00+02:00", "end_effective": "2018-01-31T01:00:00+01:00", "assignment": "2013-12-20T11:31:45+01:00", "program": 24, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 3, "manager": 59317, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "603288", "ethics_committee": null, "edudract_number": null, "persons": [ "3483-59941-12", "3483-91349-12" ] }, { "id": 3353, "title": { "de": "Vermeidung arterieller Hypotonie bei Frühgeborenen", "en": "Avoiding hypotension in preterm neonates (AHIP) - A randomised controlled study on near infrared spectroscopy monitoring of peripheral-muscle and cerebral oxygenation with defined interventions versus routine monitoring and treatment in preterm neonates" }, "short": "AHIP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2017-08-31T02:00:00+02:00", "assignment": "2013-08-14T16:35:13+02:00", "program": 79, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 50907, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3353-50907-10" ] }, { "id": 3651, "title": { "de": "Optimierung von körperlichem Training für die Prävention und Behandlung der Diastolischen Herzinsuffizienz", "en": "Optimizing Exercise Training in Prevention and Treatment of Diastolic Hert Failure" }, "short": "OptimEx", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-10-01T02:00:00+02:00", "end_planned": "2018-09-01T02:00:00+02:00", "end_effective": "2017-03-31T02:00:00+02:00", "assignment": "2014-05-02T14:11:25+02:00", "program": 24, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "602405", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3447, "title": { "de": "Charakterisierung eines neuen familiäres kolorektales Syndrom X Prädispositionsgens", "en": "Characterization of a Novel Familial Colorectal Cancer Type X Predisposition Gene" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2014-01-01T01:00:00+01:00", "end_planned": "2014-09-01T02:00:00+02:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2013-11-27T09:50:43+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 77615, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1375 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3447-51857-10", "3447-77615-10" ] }, { "id": 3340, "title": { "de": "Methylierungsanalysen von zirkulierenden Tumorzellen und weißen Blutzellen bei Brustkrebspatientinnen", "en": "Methylation analysis of circulating tumor cells and white blood cells in breast cancer patients" }, "short": null, "url": null, "abstract": { "de": "Die Identifizierung von zirkulierenden Tumorzellen (CTCs) spielt eine zunehmende Rolle in der effektiven und zielgerichteten Behandlung von Mammakarzinom Patientinnen. CTCs kommen im Blut sehr selten vor, sodass ihr Nachweis und ihre Charakterisierung eine tech- nologische Herausforderung darstellen. Molekulare Charakterisierung, wie die DNA Methylierung von CTCs, ist wichtig um neue biologische Informationen zu bekommen.\r\nWir beabsichtigen einen neuen Filter zur größenbasierten Anreicherung und Methylierungs- analyse von CTCs einzusetzen, um zu prüfen ob dieser Mikrofilter geeignet ist, sowohl CTCs und parallel beim gleichen Patienten weißen Blutzellen epigenetisch zu charakterisieren.", "en": "Identification of circulating tumor cells (CTCs) is increasingly playing an important role in the effective and targeted treatment of breast cancer patients. CTCs are very rare in the blood stream, making their isolation and characterization a major technological challenge. Molecular characterization, such as DNA methylation analysis of CTCs, is important to help extract information about their biology.\r\nWe propose to use a novel size-based microfilter to enrich for CTCs and analyze methylation in CTCs, thus evaluating the microfilter platform for its applicability to epigenetically characterize both CTCs and white blood cells from the same patient." }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2016-08-31T02:00:00+02:00", "end_effective": "2016-08-31T02:00:00+02:00", "assignment": "2013-07-22T10:39:23+02:00", "program": 79, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 50563, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3340-59188-12", "3340-50563-10", "3340-88082-12", "3340-105079-12", "3340-110608-12" ] }, { "id": 3554, "title": { "de": "Darmflora bei metabolischem Syndrom: Einfluss eines probiotischen Milchgetränks", "en": "Gut microbiota in metabolic syndrome: Influence of a probiotic milk drink " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2014-01-01T01:00:00+01:00", "end_planned": "2014-04-01T02:00:00+02:00", "end_effective": "2014-06-30T02:00:00+02:00", "assignment": "2014-02-05T14:27:45+01:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 50989, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3554-50989-10" ] }, { "id": 3251, "title": { "de": "Darmflora bei metabolischem Syndrom: Einfluss eines probiotischen Milchgetränks", "en": "Gut microbiota in metabolic syndrome: Influence of a probiotic milk drink " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2014-04-01T02:00:00+02:00", "end_effective": "2014-04-01T02:00:00+02:00", "assignment": "2013-04-24T12:09:12+02:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 50989, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3251-50989-10" ] }, { "id": 3558, "title": { "de": "Entwicklung von bioresorbierbaren Implantaten für Kinder", "en": "Development of bioresorbable implants for children with special regards to fracture healing and patient requirements" }, "short": "BRIC Phase 2", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2016-08-31T02:00:00+02:00", "end_effective": "2017-06-30T02:00:00+02:00", "assignment": "2014-02-07T10:34:22+01:00", "program": 95, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 3, "manager": 50785, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "840286", "ethics_committee": null, "edudract_number": null, "persons": [ "3558-50785-10" ] }, { "id": 3562, "title": { "de": "Semantische Datenumgebung für die Gesundheitsversorgung", "en": "Semantic Data Platform for Healthcare" }, "short": "SEMCARE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-10-01T02:00:00+02:00", "begin_effective": "2014-01-01T01:00:00+01:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2015-12-31T01:00:00+01:00", "assignment": "2014-02-10T12:08:55+01:00", "program": 24, "subprogram": "FP7-ICT-2013-SME-DCA", "organization": 14026, "category": 10, "type": 10, "partner_function": 2, "manager": 72306, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "611388", "ethics_committee": null, "edudract_number": null, "persons": [ "3562-60827-12", "3562-72306-10" ] }, { "id": 3117, "title": { "de": "Zirkulierende Tumorzellen als Biomarker für Minimal Residual Disease bei Prostatakarzinom", "en": "Circulating Tumor Cells as Biomarker for Minimal Residual Disease in Prostate Cancer" }, "short": "CTC-SCAN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-10-01T02:00:00+02:00", "begin_effective": "2013-10-01T02:00:00+02:00", "end_planned": "2016-09-30T02:00:00+02:00", "end_effective": "2018-04-30T02:00:00+02:00", "assignment": "2012-12-19T12:27:13+01:00", "program": null, "subprogram": "ERA-Net", "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 51540, "contact": 51540, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I1220", "ethics_committee": null, "edudract_number": null, "persons": [ "3117-54171-12", "3117-51540-10", "3117-60042-12" ] } ] }