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GET /v1/research/project/?format=api&offset=660&ordering=end_planned
{ "count": 2139, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=680&ordering=end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=640&ordering=end_planned", "results": [ { "id": 3264, "title": { "de": "Molekulare Mechanismen in der frühen Entwicklung von dendritischen Zellen", "en": "Regulatory mechanisms in early dendritic cell development" }, "short": null, "url": null, "abstract": { "de": null, "en": "Dendritic cells (DCs) are essential immune cells for antigen presentation and are responsible for the initiation of T-cell responses. With the exception of Langerhans cells, all subtypes of DCs are derived from bone marrow-resident hematopoietic stem cells (HSCs). DCs develop from HSCs via several specification steps and intermediate progenitor stages including common myeloid progenitor (CMP) and the monocyte/DC progenitor (MDPs) stages. \r\nThe transcription factor C/EBPa (CCAAT/enhancer binding protein alpha) is known to play an important role in early hematopoiesis. Mice with a homozygous deletion of the Cebpa gene have normal to elevated numbers of CMPs but completely lack granulocytic/monocytic progenitors (GMPs) and all subsequent granulocytic stages indicating that C/EBPa is essential for transition of early myeloid to late myeloid progenitors. Despite its critical role in early myeloid and hence DC progenitors little is known about C/EBPa in early DC development. \r\nPreliminary results from our lab using an inducible bone marrow-specific Cebpa knock-out mouse model (Mx1-Cre CebpaF/F) suggest that C/EBPa indeed has an important role in early DC development. Mice lacking Cebpa in the bone marrow display reduced numbers of both subtypes of conventional DCs (cDCs) in spleen, and even more prominent in lymph nodes and thymus, while plasmacytoid DCs are not affected. The fact that cDCs are formed albeit at reduced numbers indicates that C/EBPa is dispensable for cDC formation but is crucially involved in proliferation and/or inhibition of apoptosis in cDC precursors. In addition, it is currently not known whether cDCs formed in the absence of C/EBPa display full functional activity. Using gene expression profiling we have identified a number of C/EBPa target genes in early DC progenitors including other transcription factors, inflammatory cytokines, genes of the NF-kB-pathway, genes associated with DC maturation and distinct anti-apoptotic factors. Based on these results the aim of this project is to identify critical factors involved in differentiation, proliferation and/or inhibition of apoptosis in early DC progenitors affected by C/EBPa. To experimentally approach this goal we will use Mx1-Cre CebpaF/F experimental and Mx1-Cre Cebpawt/wt control mice and analyze DCs in spleen, lymph nodes and thymus for expression of various DC-specific surface antigens and - after isolation characterize their function. In addition, isolated FLT3+ myeloid progenitors of these mice will be stimulated with FLT3L and monitored in vitro for changes in gene expression and functionality at critical steps during DC formation. \r\n" }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2015-07-31T02:00:00+02:00", "end_effective": "2020-06-30T02:00:00+02:00", "assignment": "2013-05-08T09:53:08+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51911, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3264-51911-10", "3264-103865-12", "3264-94653-12" ] }, { "id": 2846, "title": { "de": "Modellieren eines Kollisions-Sensors aus dem Tierreich zur Entwicklung von Orientierungshilfen für Blinde oder Sehbehinderte", "en": "Modelling a collision-sensor of animals to develop devices that help blind or visually challenged person in orienting" }, "short": "Kollisions-Sensor als Orientierungshilfe", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-09-01T02:00:00+02:00", "begin_effective": "2012-09-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2016-01-31T01:00:00+01:00", "assignment": "2012-04-30T13:42:15+02:00", "program": null, "subprogram": "HTI_SMApp", "organization": 14017, "category": 10, "type": 10, "partner_function": 3, "manager": 50960, "contact": 50960, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2846-50960-10" ] }, { "id": 3031, "title": { "de": "Diagnostik mit partikelplasmon-basierten Biosensoren", "en": "n/a" }, "short": "PP-BioSens", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-09-01T02:00:00+02:00", "begin_effective": "2012-09-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2015-08-31T02:00:00+02:00", "assignment": "2012-11-06T15:03:34+01:00", "program": null, "subprogram": "Land Steiermark \"HTI:SMApp\"", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 53998, "contact": 53998, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3031-53998-10" ] }, { "id": 3353, "title": { "de": "Vermeidung arterieller Hypotonie bei Frühgeborenen", "en": "Avoiding hypotension in preterm neonates (AHIP) - A randomised controlled study on near infrared spectroscopy monitoring of peripheral-muscle and cerebral oxygenation with defined interventions versus routine monitoring and treatment in preterm neonates" }, "short": "AHIP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2017-08-31T02:00:00+02:00", "assignment": "2013-08-14T16:35:13+02:00", "program": 79, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 50907, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3353-50907-10" ] }, { "id": 3376, "title": { "de": "Netzwerk für Innovation, Transfer und Verwertung von Medizinprodukten", "en": "Dynamic Network Arranged for Medical Device Innovation, Transfer & Exploitation" }, "short": "DYNAMITE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2015-12-31T01:00:00+01:00", "assignment": "2013-09-18T13:27:30+02:00", "program": 104, "subprogram": "Kooperation und Netzwerke", "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "840131", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3717, "title": { "de": "Untersuchung der psychometrischen Gütekriterien der deutschen Fassung der Parental Stressor Scale (PSS:NICU)", "en": "Examination of the psychometric properties of the German Parental Stressor Scale (PSS:NICU_German)" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-02-07T01:00:00+01:00", "begin_effective": "2014-07-15T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2015-10-31T01:00:00+01:00", "assignment": "2014-07-21T10:40:32+02:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 50907, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3717-50907-10" ] }, { "id": 3338, "title": { "de": "Rolle von Tumorstammzell-assoziierten non-coding RNAs beim hepatozellulären Karzinom", "en": "Role of stem cell-associated non-coding RNAs in hepatocellular carcinoma" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2013-07-18T16:36:18+02:00", "program": 81, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 53557, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 52 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3338-53557-10" ] }, { "id": 3092, "title": { "de": "Erforschung der Abbauprodukte von neuen Implantatmaterialien in der Unfallchirurgie", "en": "Investigation of degradation products of novel implant materials used in accident surgery" }, "short": "degIMMAT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-09-01T02:00:00+02:00", "begin_effective": "2012-09-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2015-08-31T02:00:00+02:00", "assignment": "2012-12-06T11:35:04+01:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50785, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1166 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3092-50785-10" ] }, { "id": 3789, "title": { "de": "Diagnostische Klebsielle oxytoca PCR", "en": "Diagnostic Klebsielle oxytoca PCR" }, "short": "K.oxy PCR", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-09-01T02:00:00+02:00", "begin_effective": "2014-10-01T02:00:00+02:00", "end_planned": "2015-09-01T02:00:00+02:00", "end_effective": "2015-12-31T01:00:00+01:00", "assignment": "2014-10-16T12:31:56+02:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 50527, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3789-50527-10" ] }, { "id": 3562, "title": { "de": "Semantische Datenumgebung für die Gesundheitsversorgung", "en": "Semantic Data Platform for Healthcare" }, "short": "SEMCARE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-10-01T02:00:00+02:00", "begin_effective": "2014-01-01T01:00:00+01:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2015-12-31T01:00:00+01:00", "assignment": "2014-02-10T12:08:55+01:00", "program": 24, "subprogram": "FP7-ICT-2013-SME-DCA", "organization": 14026, "category": 10, "type": 10, "partner_function": 2, "manager": 72306, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "611388", "ethics_committee": null, "edudract_number": null, "persons": [ "3562-60827-12", "3562-72306-10" ] }, { "id": 2697, "title": { "de": "Herzinsuffizienzforschung an der Medizinischen Universität Graz", "en": "Herzinsuffizienzforschung an der Medizinischen Universität Graz" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2011-12-19T10:48:05+01:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2697-59941-12", "2697-60390-12", "2697-62075-12", "2697-62747-12", "2697-58906-12", "2697-60041-12", "2697-60377-12", "2697-75758-12", "2697-78591-12", "2697-83082-12", "2697-89052-12" ] }, { "id": 3751, "title": { "de": "Der Anstieg des pulmonalen Blutflusses nach der Geburt.", "en": "Understanding the increase in pulmonary blood flow at birth." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-10-01T02:00:00+02:00", "begin_effective": "2014-10-01T02:00:00+02:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2014-08-20T11:39:49+02:00", "program": 69, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 73733, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "J3595", "ethics_committee": null, "edudract_number": null, "persons": [ "3751-73733-10" ] }, { "id": 2916, "title": { "de": "ApoA-I und ApoJ beeinflussen den Amyloid-beta Metabolismus an der Blut-Hirn-Schranke", "en": "Implications of apoA-I and apoJ as modulators of amyloid beta metabolism in brain capillary endothelial cells of the blood-brain barrier" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-10-01T02:00:00+02:00", "begin_effective": "2013-03-01T01:00:00+01:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2018-02-28T01:00:00+01:00", "assignment": "2012-07-17T12:22:27+02:00", "program": 72, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P24783", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3721, "title": { "de": "Disseminierende Tumorzellen in primär metastasierten Brustkrebspatientinnen mit Chirurgie des Primärtumors ", "en": "Disseminating tumor cells in primary metastasized breast cancer patients undergoing surgery of primary tumor" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-10-01T02:00:00+02:00", "begin_effective": "2014-10-01T02:00:00+02:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2014-07-23T16:36:55+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 122 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3484, "title": { "de": "Zell-basierte regenerative Medizin: Neue Herausforderungen für EU Legislatur und Governance", "en": "Cell-based regenerative medicine: new challenges for EU legislation and governance" }, "short": "EUCelLEX", "url": null, "abstract": { "de": null, "en": "This proposal aims at collecting and analysing facts and figures in order to assess the current legislation on\r\nthe therapeutic use of somatic cells, and to bridge it with the research infrastructure capacity building. Although\r\nEU has adopted 3 Directives on Tissues and cells between 2004 and 2006 to harmonise the procurement,\r\nstorage and use of cells for therapeutic use in Europe, countries have implemented these directives in very\r\ndifferent ways. Furthermore, research has been partially covered by the initial regulation, calling into question the\r\nmatch between regulation and practices that will develop in the near future, in particular with the emergence of\r\nEuropean research infrastructures. Finally many changes have occurred in the scientific, legal and institutional\r\nenvironment of cell use, leading to a necessary update of this regulation with regards to its implementation in\r\nnational legislation and its impact on research practice and innovation. Two domains are at stake: research\r\n(infrastructures) and medical practice/public health measures (cells). The therapeutic use of cells is regulated by\r\nEU law whereas its research counterpart is mainly depending on national laws and regulations. This gap calls for\r\na coordinated action in order to optimize the translational process, since the full pipeline is not coherently taken\r\ninto account in current legislations. To achieve these objectives, our project relies on a coherent consortium\r\nof experts in the fields of cells therapies, cells banks and translational biomedicine, having strong expertise\r\nin law and/ or in governance issues. After 36 months the project will deliver evidence about the contemporary\r\npractices around cells and will design a picture of the market and its distribution between the public and private\r\nsector. The project will thus help the Commission in the regulatory choices covering the use of human cells for\r\ntherapeutic purposes and to foster the innovation potential of related research activities." }, "begin_planned": "2013-10-01T02:00:00+02:00", "begin_effective": "2013-10-01T02:00:00+02:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2016-09-30T02:00:00+02:00", "assignment": "2013-12-20T12:06:22+01:00", "program": 24, "subprogram": "Health FP7-HEALTH-2013-INNOVATION-1", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "601806", "ethics_committee": null, "edudract_number": null, "persons": [ "3484-51663-10" ] }, { "id": 2792, "title": { "de": "Immunmodulierende Strategien für die Behandlung des Merkelzell-Karzinoms (IMMOMEC).", "en": "Immune modulating strategies for treatment of Merkel cell carcinoma (IMMOMEC)." }, "short": "IMMOMEC", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-01T02:00:00+02:00", "begin_effective": "2012-01-01T01:00:00+01:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2016-12-31T01:00:00+01:00", "assignment": "2012-02-15T16:29:57+01:00", "program": 24, "subprogram": "Health 2011.2.4.1-1 ", "organization": 14047, "category": 10, "type": 10, "partner_function": 3, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "277775", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3052, "title": { "de": "Adrenerge Regulation der CaV1.2 L-Typ Kalziumkanäle Dynamik in Neuronen", "en": "Adrenergic regulation of CaV1.2 L-type calcium channel dynamics in neurons" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-10-01T02:00:00+02:00", "begin_effective": "2012-11-01T01:00:00+01:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2016-09-30T02:00:00+02:00", "assignment": "2012-11-26T15:44:00+01:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P25085", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3793, "title": { "de": "Identifizierung von putativen Krebs-Stammzellen in Adenocarcinoma der Lunge mittels Next Generation Sequencing.", "en": "Biomarkers of putative cancer stem cells in adenocarcinoma of the lung identified by\r\nnext generation sequencing\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-10-01T02:00:00+02:00", "begin_effective": "2014-10-01T02:00:00+02:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2016-11-30T01:00:00+01:00", "assignment": "2014-10-23T11:54:42+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 122 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3793-59188-12", "3793-50563-12", "3793-50539-12" ] }, { "id": 3674, "title": { "de": "Die Rolle des Orai N-Terminus und des 2. Loops in der Kopplung mit STIM1", "en": "The role of Orai N-terminus and loop 2 in the coupling with STIM1" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-10-08T02:00:00+02:00", "begin_effective": "2012-10-08T02:00:00+02:00", "end_planned": "2015-10-07T02:00:00+02:00", "end_effective": "2015-10-07T02:00:00+02:00", "assignment": "2014-05-27T16:39:36+02:00", "program": 72, "subprogram": "Nachmeldung zu einem Projekt, dass bereits vorweg an den FWF weitergeleitet wurde und bewilligt wurde.", "organization": 14011, "category": 10, "type": 10, "partner_function": 2, "manager": 78591, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 25172", "ethics_committee": null, "edudract_number": null, "persons": [ "3674-78591-10" ] }, { "id": 3099, "title": { "de": "Parodontale Therapie und Reduktion der Gefäßinflammation bei Patienten mit peripherer arterieller Verschlusskrankheit", "en": "Periodontal treatment and reduction of vascular inflammation in patients with peripheral arterial disease" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-11-01T01:00:00+01:00", "begin_effective": "2013-01-01T01:00:00+01:00", "end_planned": "2015-10-31T01:00:00+01:00", "end_effective": "2018-01-01T01:00:00+01:00", "assignment": "2012-12-10T11:16:43+01:00", "program": 108, "subprogram": "KLIF", "organization": 14079, "category": 10, "type": 10, "partner_function": 4, "manager": 52018, "contact": 52018, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI256", "ethics_committee": null, "edudract_number": null, "persons": [ "3099-52018-10" ] } ] }