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GET /v1/research/project/?format=api&offset=640&ordering=end_effective
{ "count": 2157, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=660&ordering=end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=620&ordering=end_effective", "results": [ { "id": 2525, "title": { "de": "Genetische Typisierung von Klebsiella oxytoca Stämmen in Bezug auf deren Fähigkeit zur Toxinproduktion und Assoziation zur Entstehung von Colitis.", "en": "Typing of Klebsiella oxytoca Strains Concerning to their Ability for Toxin-Production and their Association to the Develoment of Colitis." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2014-01-01T01:00:00+01:00", "end_effective": "2014-10-31T01:00:00+01:00", "assignment": "2011-07-12T16:25:15+02:00", "program": 79, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 53167, "contact": 53167, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2525-53167-10" ] }, { "id": 2146, "title": { "de": "AP@home", "en": "AP@home" }, "short": "AP@home", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-10-01T02:00:00+02:00", "begin_effective": "2010-02-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-10-31T01:00:00+01:00", "assignment": "2010-03-02T11:22:16+01:00", "program": 24, "subprogram": "ICT: FP7-ICT-2009-4", "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": 51831, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2146-51831-10", "2146-50877-12", "2146-56674-12", "2146-73507-12", "2146-61759-12", "2146-50731-12" ] }, { "id": 2623, "title": { "de": "Entwicklung, Charakterisierung und Validierung neuer Vliesstoff-Wirkstoff-Kombinationen für die medizinische Anwendung im Knochen- und Weichteilgewebe - ProjektNr: 832147", "en": "Development, characterization and validation new fleece-drug combinations for the medical application in bone and Soft tissue" }, "short": "VW Kombi", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-30T02:00:00+02:00", "begin_effective": "2011-12-01T01:00:00+01:00", "end_planned": "2013-09-30T02:00:00+02:00", "end_effective": "2014-11-30T01:00:00+01:00", "assignment": "2011-11-02T11:42:57+01:00", "program": 60, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50785, "contact": 60165, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "832147 ", "ethics_committee": null, "edudract_number": null, "persons": [ "2623-50785-10" ] }, { "id": 3165, "title": { "de": "Phenotyping Fragile X Syndrome for the first two years of life", "en": "Phenotyping Fragile X Syndrome for the first two years of life" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-12-01T01:00:00+01:00", "begin_effective": "2012-12-01T01:00:00+01:00", "end_planned": "2014-11-30T01:00:00+01:00", "end_effective": "2014-11-30T01:00:00+01:00", "assignment": "2013-02-06T14:50:06+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2549, "title": { "de": "Postoperative altersentsprechende Akutschmerzerfassung bei Kindern und Jugendlichen", "en": "postoperative age-related assessment of acute pain in children and adolescents" }, "short": "POSTOPERATIVE AGE-RELATED ACUTE PAIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-09-01T02:00:00+02:00", "end_planned": "2013-06-30T02:00:00+02:00", "end_effective": "2014-11-30T01:00:00+01:00", "assignment": "2011-07-29T11:15:50+02:00", "program": 79, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 50785, "contact": 50785, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2549-50785-10" ] }, { "id": 2785, "title": { "de": "Genetische Analyse der Multiplen Chemikalien-Sensitivität (MCS) mit Exom-Sequenzierung", "en": "Analysis of the genetic basis of multiple chemical sensitivity (MCS) by exome sequencing" }, "short": "MCSEXOM", "url": null, "abstract": { "de": "Multiple Chemikalien-Sensitivität (MCS) ist ein Krankheitsbild der Umweltmedizin, das unzureichend charakterisiert ist und nur symptomatisch im Ausschlussverfahren diagnostiziert werden kann, da die genaue Pathogenese unbekannt ist. Das vorliegende Projekt will herausfinden, ob (1) Exom-Sequenzierung genetische Risikofaktoren für MCS identifizieren kann, (2) MCS mit genetisch bedingten Unterschieden molekularer Chemosensoren zusammenhängt und (3) Genvarianten, MCS-Symptome und psychometrische Eigenschaften der Patienten/innen zusammenhängen. Erstmals an MCS-PatientInnen angewandt, kann die kostengünstige Technologie der Exom-Sequenzierung ganz neue genetische\r\nRisikofaktoren und Gen-Komplexe mit Relevanz für MCS aufklären. Außerdem wird mit dieser Methode untersucht, ob MCS-PatientInnen deshalb verstärkt auf Chemikalien reagieren, weil Unterschiede in den Genen für Chemosensoren eine\r\nChemikalienüberempfindlichkeit bedingen.", "en": "Multiple chemical sensitivity (MCS) is an environmental illness of unkown aetiology. Since evidence for an involvement of xenobiotic-metabolizing enzymes is lacking, the current proposal will test the hypotheses that (1) genetic risk factors for MCS can be identified by exome sequencing and (2) MCS is related to polymorphisms in genes relevant to chemosensation. First applied to MCS patients, exome sequencing will break new ground in the elucidation of the genetic basis of this illness. This cost-efficient technology will identify not only target genes associated with MCS but also complex genetic patterns underlying MCS. Exome sequencing will also be used to examine whether MCS is due to exaggerated chemosensation, because\r\npolymorphisms in genes relevant to chemosensation are likely to predispose for hypersensitivity to chemicals. In these goals, the project has great potential in identifying a possibly genetic cause of MCS and providing leads for the diagnosis and therapy\r\nof MCS." }, "begin_planned": "2011-12-01T01:00:00+01:00", "begin_effective": "2012-02-01T01:00:00+01:00", "end_planned": "2014-11-30T01:00:00+01:00", "end_effective": "2014-11-30T01:00:00+01:00", "assignment": "2012-02-14T14:26:33+01:00", "program": 90, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 3, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 957 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2649, "title": { "de": "Identifizierung von Biomarkern aus zirkulierenden Tumorzellen", "en": "Identification of biomarkers from circulating tumor cells" }, "short": "CTC", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2013-04-30T02:00:00+02:00", "end_effective": "2014-11-30T01:00:00+01:00", "assignment": "2011-11-25T11:07:38+01:00", "program": 72, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 1, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P23284", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2637, "title": { "de": "Entwicklung, Charakterisierung und Validierung neuer Vliesstoff-Wirkstoff-Kombinationen für die medizinische Anwendung im Knochen- und Weichteilgewebe - ProjektNr: 832147", "en": "Entwicklung, Charakterisierung und Validierung neuer Vliesstoff-Wirkstoff-Kombinationen für die medizinische Anwendung im Knochen- und Weichteilgewebe" }, "short": "VW Kombi", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-30T02:00:00+02:00", "begin_effective": "2011-12-01T01:00:00+01:00", "end_planned": "2013-09-30T02:00:00+02:00", "end_effective": "2014-11-30T01:00:00+01:00", "assignment": "2011-11-17T16:13:53+01:00", "program": 60, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 2, "manager": 51503, "contact": 51503, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "832147 ", "ethics_committee": null, "edudract_number": null, "persons": [ "2637-51503-10" ] }, { "id": 3440, "title": { "de": "Der Basophilen-Aktivierungstest als Diskriminator zwischen Bienen- und Wespengiftallergie", "en": "Accuracy of the basophil activation test in the differentiation between bee and wasp venom allergy" }, "short": "ISIREDS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-11-01T01:00:00+01:00", "begin_effective": "2013-02-01T01:00:00+01:00", "end_planned": "2012-10-31T01:00:00+01:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2013-11-21T11:59:18+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 87717, "contact": 87717, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1161 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3440-87717-10" ] }, { "id": 2306, "title": { "de": "Zellbasierte nichtinvasive Pränataldiagnostik", "en": "Cell-based non-invasive prenatal diagnosis" }, "short": "ZELLBAS NICHTINV PRAENATALDIAG", "url": null, "abstract": { "de": "Genetische Pränataldiagostik erfordert die Gewinnung von Zellen des Kindes. Dies erfolgt durch invasive Methoden wie Amniozentese oder Chorionzottenbiopsie. Das Risiko, daß es durch diese Eingriffe zu einem Abort kommt, ist nicht vernachlässigbar und liegt bei 0,5 1%. Aus diesem Grund ist genetische Pränataldiagnostik auf Schwangerschaften mit einem erhöhten Risiko einer genetischen Krankheit des Fetus beschränkt, wie z. B. einem Alter der Schwangeren von über 35 Jahren. Tatsächlich wird aber die Mehrzahl von Kindern mit genetischen Krankheiten nach Schwangerschaften geboren, die nicht primär als mit erhöhtem Risiko behaftet eingestuft werden können und bei denen das Risiko einer invasive Diagnostik in keinem vertretbaren Verhältnis zum Risiko durch den Eingriff steht.\r\nAusgehend von einer von uns entwickelten Methode zur geschlechtsunabhängigen Analyse der fötalen Identität von Zellen wollen wir in dem vorgeschlagenen Projekt ein Verfahren etablieren, das auf der Basis der Analyse von Einzelzellen eine nicht-invasive pränatale Diagnostik numerischer Chromosomenaberrationen und monogenetisch bedingter Krankheiten ermöglicht. Wir vergleichen die Effizienz etablierter Protokolle zur Anreicherung fetaler Zellen aus dem peripheren Blut schwangerer Frauen. Weiters etablieren wir die Amplifikation des gesamten Genoms von Einzelzellen, kombinieren die Analyse der fetalen Identität mittels array comparative genomic hybridization zur Analyse von Trisomien und analysieren als Beispiel der prinzipiellen Machbarkeit Mutationen des CFTR Gens.\r\nAuf Basis dieser Arbeiten wollen wir unter Nutzung von Ressourcen der Medizinischen Universität Graz im Sinn einer kommerziellen Anwendung ein überregionales Zentrum zur zellbasierten nichtinvasiven Pränataldiagnostik etablieren.\r\n", "en": "Genetic prenatal diagnosis is dependent on procurement of fetal cells. This is done my invasive methods such as amniocentesis and chorionic villous sampling. These methods are associated to a risk of 0.5 1% of subsequent abortus. For this reason genetic prenatal diagnosis is restricted to pregnancies with are associated with an increased risk of renetik disease of the fetus, such as age of the pregnant women higher than 35 years. In fact the majority of children with genetic diseases is born at the end of pregnancies which have not abeen associated with an increased risk, where the risk of invasive procedures cannot be justified.\r\nBased on a method which we developed previously for sex-independent analysis of the fetal identity of cells in a fetal microchimeric setting, we plan to establish a technique allowing for non-invasive prenatal diagnosis of both numeric chromosomal aberrations and monogenetic hereditary diseases, using analysis of single cells. We will compare the efficiency of established protocols for enrichment of fetal cells from the peripheral blood of pregnant women. Furthermore, we will establish whole genome amplification of single cells and combine the analysis of fetal identity with analysis of trisomy by means of array comparative genomic hybridization. As a proof of principle for feasibility of analysis of monogenic hereditary diseases using the preamplified genome of single cells we will analyze mutations of the CFTR gene.\r\nThe results of this work will be commercially exploited as we plan to establish an supra-regional center for cell-based non-invasive prenatal diagnosis by using the facilities of the Medical University of Graz.\r\n" }, "begin_planned": "2010-03-01T01:00:00+01:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2013-02-28T01:00:00+01:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2010-09-17T13:41:38+02:00", "program": 71, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 51540, "contact": 51540, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "TRP17 ", "ethics_committee": null, "edudract_number": null, "persons": [ "2306-54171-12", "2306-51540-10" ] }, { "id": 2531, "title": { "de": "Lipasen und lipotoxische Lipid in Makrophagen: Rolle in der Atherogenese", "en": "Lipases and lipotoxic lipids in macrophages: Role in atherogenesis" }, "short": "LIPASES AND LIPOTOXIC LIPIDS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-04-01T02:00:00+02:00", "begin_effective": "2011-04-01T02:00:00+02:00", "end_planned": "2014-03-31T02:00:00+02:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2011-07-14T17:09:54+02:00", "program": 67, "subprogram": "P04", "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51904, "contact": 51904, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "F30", "ethics_committee": null, "edudract_number": null, "persons": [ "2531-51904-10" ] }, { "id": 3577, "title": { "de": "Vergleich der von Qualitätssicherung und Qualitätskontrolle in der Diagnostischen Radiologie von Österreich und Montenegro", "en": "Comparision of QA/QC in diagnostic radiology in Montenegro and Austria" }, "short": " ME 10/2013", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-01-01T01:00:00+01:00", "end_planned": "2014-12-31T01:00:00+01:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2014-02-17T15:34:51+01:00", "program": 92, "subprogram": "WTZ -- Wissenschaftlich technische Zusammenarbeit -- wurde verlängert bis 30.6.2015", "organization": 14106, "category": 10, "type": 10, "partner_function": 1, "manager": 51913, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3577-51913-10" ] }, { "id": 3194, "title": { "de": "Einfluss von LAMA4 Hemmung auf die Organisation von Knorpelzellen im 3 D Model", "en": "LAMA4 inhibition leads to cluster deformation in human osteoarthritic cartilage in a 3 Dimensional matrix model" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-08-01T02:00:00+02:00", "begin_effective": "2012-08-01T02:00:00+02:00", "end_planned": "2013-08-01T02:00:00+02:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2013-03-01T09:09:42+01:00", "program": 79, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 4, "manager": 57343, "contact": 57343, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3194-57343-10", "3194-78952-12" ] }, { "id": 3476, "title": { "de": "Hyperkapnie ist unter präklinischer Reanimation häufig und mit dem Outcome assoziiert", "en": "Hypercapnia is common during out-of-hospital cardiopulmonary resuscitation and affects outcome" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-01-01T01:00:00+01:00", "end_planned": "2014-12-31T01:00:00+01:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2013-12-19T11:38:05+01:00", "program": null, "subprogram": "Preis", "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 54296, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1330 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3476-54296-10" ] }, { "id": 3495, "title": { "de": "Does an altered expression of HCN channel isoforms underlie the observed changes in electrophysiological characteristics of the pacemaker current If in cardiomyocytes isolated from a pig model of atrial fibrillation and arterial hypertension?", "en": "Does an altered expression of HCN channel isoforms underlie the observed changes in electrophysiological characteristics of the pacemaker current If in cardiomyocytes isolated from a pig model of atrial fibrillation and arterial hypertension?" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-01-01T01:00:00+01:00", "begin_effective": "2014-01-01T01:00:00+01:00", "end_planned": "2014-12-31T01:00:00+01:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2014-01-02T15:01:14+01:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 50969, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3495-50615-12", "3495-50990-12", "3495-50969-10" ] }, { "id": 3625, "title": { "de": "Vitamin D bindendes Protein (DBP) und die Effizienz einer Vitamin D Einnahme in der Steirischen Vitamin D Bluthochdruckstudie", "en": "Vitamin D binding protein (DBP) and the efficiency of vitamin D supplementation in the Styrian Hypertension Study" }, "short": "DBP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-03-01T01:00:00+01:00", "begin_effective": "2014-03-01T01:00:00+01:00", "end_planned": "2014-12-31T01:00:00+01:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2014-04-03T12:34:07+02:00", "program": null, "subprogram": "ÖGKM Projektpreis", "organization": 14080, "category": 10, "type": 10, "partner_function": 1, "manager": 81051, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1565 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3625-81051-10" ] }, { "id": 2335, "title": { "de": "Steirische Vitamin D Bluthochdruck Studie", "en": "Styrian Vitamin D Hypertension Study" }, "short": "STEIRISCHE_BLUTHOCHDRUCK_STUDIE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-08-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2013-07-31T02:00:00+02:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2010-11-10T10:05:48+01:00", "program": 79, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 53344, "contact": 53344, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2335-53344-10" ] }, { "id": 2294, "title": { "de": "Der CRTH2 Rezeptor in experimenteller Colitis ulcerosa", "en": "The CRTH2 receptor in experimental ulcerative colitis" }, "short": "CRTH2 RECEPTOR EXP ULC COLITIS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-09-01T02:00:00+02:00", "begin_effective": "2010-08-01T02:00:00+02:00", "end_planned": "2013-08-31T02:00:00+02:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2010-09-07T14:00:00+02:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 56687, "contact": 56687, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P22771", "ethics_committee": null, "edudract_number": null, "persons": [ "2294-56687-10" ] }, { "id": 2528, "title": { "de": "Pilze als Indikatoren für pathogeninaktivierende Eigenschaften eines neuen Fixativs für die Gewebekonservierung", "en": "Fungi as indicators for pathogen inactivating capacity of a novel fixative employed on tissue preservation" }, "short": "3P", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2013-03-31T01:00:00+01:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2011-07-13T15:48:48+02:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 50828, "contact": 50828, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 895 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2528-50828-10" ] }, { "id": 1907, "title": { "de": "Hochdurchsatz-Genexpressionsanalyse im Gehirn verhaltensdivergenter Rattenstämme in Abhängigkeit von Stressexposition und Geschlechtszugehörigkeit", "en": "High throughput gene expression analysis in the brain of behaviourally divergent rat strains under the influence of stress exposure and gender" }, "short": "HOCHDURCHSATZ_GENEXPRESS", "url": null, "abstract": { "de": "Die Begriffe \"stress\" und \"burnout\" sind mittlerweile sprachliches Gemeingut, ihre biomedizinische Bedeutung ist aber, aufgrund nach wie vor fehlender basaler molekularer Konzepte, keineswegs vollständig erfassbar, was allerdings im Sinne adäquater, effizienter Therapieansätze unbedingt nötig wäre.\r\nZur Analyse der möglichen genetischen Determination individueller, wie auch geschlechtsspezifischer Stress-Suszeptibilität wurden bisher stets Tiermodelle herangezogen, in denen a priori definierte Parameter, wie die Expression bekannter Transkriptionsverfahren oder Neurotransmitter als Maß selektiver neuronaler Akrivierung dienten.\r\nDem gegenüber zielt das vorliegende Projektvorhaben darauf ab, innerhalb eines etablierten tierexperimentellen psychologischen Stressmodells, in einem Hochdurchsatz-Prozess mittels automatisierter whole transcriptome analysis durch Microarray-Technologie simultan die Gesamtheit aller stressaktiviertern Gene in bekannten Stresszentren des Gehirns zu erfassen. \r\nAufgrund von bereits erfolgten technischen Vorstudien darf von den Resultaten dieser Studie erwartet werden, wertvolle neue wissenschaftliche Stossrichtungen bezüglich der Aufklärung molekularer Mechanismen geschlechtsspezifischer, Stress-Antwort des Gehirns zu eröffnen.", "en": "Die Begriffe \"stress\" und \"burnout\" sind mittlerweile sprachliches Gemeingut, ihre biomedizinische Bedeutung ist aber, aufgrund nach wie vor fehlender basaler molekularer Konzepte, keineswegs vollständig erfassbar, was allerdings im Sinne adäquater, effizienter Therapieansätze unbedingt nötig wäre.\r\nZur Analyse der möglichen genetischen Determination individueller, wie auch geschlechtsspezifischer Stress-Suszeptibilität wurden bisher stets Tiermodelle herangezogen, in denen a priori definierte Parameter, wie die Expression bekannter Transkriptionsverfahren oder Neurotransmitter als Maß selektiver neuronaler Akrivierung dienten.\r\nDem gegenüber zielt das vorliegende Projektvorhaben darauf ab, innerhalb eines etablierten tierexperimentellen psychologischen Stressmodells, in einem Hochdurchsatz-Prozess mittels automatisierter whole transcriptome analysis durch Microarray-Technologie simultan die Gesamtheit aller stressaktiviertern Gene in bekannten Stresszentren des Gehirns zu erfassen. \r\nAufgrund von bereits erfolgten technischen Vorstudien darf von den Resultaten dieser Studie erwartet werden, wertvolle neue wissenschaftliche Stossrichtungen bezüglich der Aufklärung molekularer Mechanismen geschlechtsspezifischer, Stress-Antwort des Gehirns zu eröffnen." }, "begin_planned": "2009-08-01T02:00:00+02:00", "begin_effective": "2009-10-01T02:00:00+02:00", "end_planned": "2010-01-31T01:00:00+01:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2009-09-03T16:02:11+02:00", "program": null, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": 51205, "contact": 51205, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1907-51205-10" ] } ] }