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GET /v1/research/project/?format=api&offset=600&ordering=-end_planned
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=620&ordering=-end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=580&ordering=-end_planned", "results": [ { "id": 8140, "title": { "de": "Entschlüsselung von Alzheimer: \r\nTRPC1 als zentrale Figur bei Protein-Entfaltung und Cholesterin-Biosynthese\r\n", "en": "Deciphering Alzheimer's: \r\nTRPC1 as a central player in protein unfolding and cholesterol biosynthesis" }, "short": null, "url": null, "abstract": { "de": "Hintergrund: Die Alzheimer-Krankheit (AD) ist eine irreversible und tödliche Form von Demenz, unterteilt in sporadische (SAD) und familiäre AD (FAD). FAD, mit frühem Beginn aufgrund spezifischer Genmutationen, steht im Gegensatz zu SAD, das einen späten Beginn und eine unklare Ursache aufweist. Die Ca2+-Homöostase- Hypothese von SAD legt nahe, dass eine frühzeitige Ca2+-Dysregulation mit der Fehlfaltung von Proteinen und der Anreicherung von Cholesterin einhergeht. Das endoplasmatische Retikulum (ER) ist entscheidend für die Regulation des intrazellulären Ca2+, die Verarbeitung von Proteinen und die Lipid-Biosynthese. Die Familie der transienten Rezeptorpotenzial-Kanäle (TRPC1-7) umfasst TRPC1, der im Hippocampus stark exprimiert wird. Während TRPC2-7 ausschließlich in der Plasmamembran gefunden werden, befindet sich TRPC1 auch in der ER- Membran.\r\nHypothese: TRPC1 könnte an der Regulation von Ca2+, der Synthese von Proteinen und Cholesterin im ER beteiligt sein.\r\nErgebnisse: Vorläufige Experimente zeigten, dass TRPC1 den Ca2+-Leck aus dem ER signifikant verstärkte, den Cholesterinspiegel in TRPC1-transfizierten HEK293-Zellen erhöhte, den Cholesterinspiegel in den Hippocampi transgener Mäuse im Alter veränderte und die Expression von Transkriptionsfaktoren beeinflusste, die an der Proteinfaltung beteiligt sind.\r\nFazit: Eine weitere Erforschung der Rolle von TRPC1 im ER könnte ihn als potenzielles pharmazeutisches Ziel in der AD-Behandlung etablieren.", "en": "Background: Alzheimer’s disease (AD) is an irreversible and fatal form of dementia, divided into sporadic (SAD) and familial AD (FAD). FAD, with early onset due to specific gene mutations, contrasts SAD, with late onset and an unclear cause. The Ca2+ homeostasis hypothesis of SAD suggests early Ca2+ dyshomeostasis links to protein misfolding and cholesterol accumulation. The endoplasmic reticulum (ER) is crucial, managing intracellular Ca2+, protein processing, and lipid biosynthesis. The transient receptor potential canonical family (TRPC1-7) includes TRPC1, highly expressed in the hippocampus. While TRPC2-7 target the plasma membrane, TRPC1 is also found in the ER membrane.\r\nHypothesis: TRPC1 may be involved in Ca2+ handling, protein, and cholesterol synthesis in the ER.\r\nResults: Preliminary experiments showed TRPC1 increased Ca2+ leak from the ER, elevated cholesterol in TRPC1- transfected HEK293 cells, altered cholesterol levels in hippocampi from aged transgenic mice, and affected expression of transcription factors involved in protein folding.\r\nConclusion: Further exploring TRPC1 role in the ER could establish it as a potential pharmaceutical target in AD treatment." }, "begin_planned": "2024-03-01T01:00:00+01:00", "begin_effective": "2024-03-01T01:00:00+01:00", "end_planned": "2025-02-28T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-04-16T14:17:18+02:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 90337, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8140-90337-10", "8140-116421-12", "8140-122690-12" ] }, { "id": 6971, "title": { "de": "Mütterliche Blutplättchen und extravillöse Trophoblasten", "en": "Maternal platelets and extravillous trophoblasts" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-03-01T01:00:00+01:00", "begin_effective": "2022-09-01T02:00:00+02:00", "end_planned": "2025-02-28T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2022-03-24T09:19:41+01:00", "program": 72, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 53232, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P35118", "ethics_committee": null, "edudract_number": null, "persons": [ "6971-53232-10" ] }, { "id": 8172, "title": { "de": "Entschlüsselung der Rolle der metabolischen Reprogrammierung in Neutrophilen bei Lungenkrebs", "en": "Deciphering the Role of Metabolic Reprogramming in Neutrophils During Lung Cancer" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-02-01T01:00:00+01:00", "begin_effective": "2023-01-01T01:00:00+01:00", "end_planned": "2025-01-31T01:00:00+01:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2024-05-02T11:23:05+02:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 1, "manager": 115261, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894, 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8172-115261-10" ] }, { "id": 7958, "title": { "de": "Elektrophysiologische Charakterisierung der induzierten Zellalterung zur Krebstherapie", "en": "Electrophysiological characterization of induced cell aging for cancer therapy" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-01T01:00:00+01:00", "begin_effective": "2024-02-01T01:00:00+01:00", "end_planned": "2025-01-31T01:00:00+01:00", "end_effective": "2025-07-31T02:00:00+02:00", "assignment": "2023-12-27T17:07:11+01:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 2, "manager": 50615, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7958-50615-10" ] }, { "id": 7934, "title": { "de": "Maschinelles Hören im Kreißsaal: Pilotstudie zur automatischen Evaluierung der neonatalen Lungenfunktion anhand des ersten Schreis", "en": "Maschinelles Hören im Kreißsaal: Pilotstudie zur automatischen Evaluierung der neonatalen Lungenfunktion anhand des ersten Schreis" }, "short": "Maschinelles Hören im Kreißsaal", "url": null, "abstract": { "de": "Die in den ersten Lebensminuten produzierten Laute von Neugeborenen sorgen dafür, dass ein Teil der Ausatemluft vom Kehlkopf zurückpendelt und so das Fruchtwasser aus der Lunge in das umliegende Gewebe presst. Aufgrund unterschiedlich fortgeschrittener Lungenentwicklung gibt es mitunter hörbare Unterschiede zwischen Termin- und Frühgeborenen. Dieses Projekt evaluiert die Durchführbarkeit von standardisierten Tonaufnahmen in der Geburtssituation. Basierend auf Pilotdaten erfolgt erstmals eine umfassende Beschreibung akustischer Merkmale der ersten Laute von Termin- und Frühgeborenen sowie die Validierung künstlicher Intelligenz zur Einschätzung neonataler Lungenfunktion.", "en": null }, "begin_planned": "2024-01-15T01:00:00+01:00", "begin_effective": "2024-03-01T01:00:00+01:00", "end_planned": "2025-01-14T01:00:00+01:00", "end_effective": "2025-05-31T02:00:00+02:00", "assignment": "2023-12-15T12:07:02+01:00", "program": null, "subprogram": null, "organization": 14068, "category": 10, "type": 10, "partner_function": 4, "manager": 79651, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7934-79651-10", "7934-91531-12", "7934-77049-12" ] }, { "id": 9130, "title": { "de": "Auf dem Weg zu einem umfassenden Atlas des menschlichen Atmungsmikrobioms: Taxonomische, genomische und funktionelle Perspektiven", "en": "Towards a Comprehensive Atlas of the Human Respiratory Microbiome: Taxonomic,\r\nGenomic, and Functional Perspectives" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-08-01T02:00:00+02:00", "end_planned": "2025-01-01T01:00:00+01:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2025-08-05T13:14:59+02:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 90021, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9130-90021-10" ] }, { "id": 7852, "title": { "de": "Ein Stammzellpflaster als Therapiemöglichkeit für Verletzungen der juvenilen Wachstumsfuge", "en": "A stem cell sheet as a therapeutic option for juvenile growth plate injuries" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2026-09-30T02:00:00+02:00", "assignment": "2023-10-24T16:18:54+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 100991, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7852-100991-10" ] }, { "id": 7622, "title": { "de": "EVI 2.0 - Evidenzbasierte Informationen zur Unterstützung von gesundheitskompetenten Entscheidungen", "en": "EVI 2.0 - Evidence-based health information to increase health literacy" }, "short": "EVI 2.0", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-01-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2023-06-19T11:56:03+02:00", "program": null, "subprogram": null, "organization": 27964, "category": 10, "type": 10, "partner_function": 4, "manager": 51117, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2160 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7622-51117-10" ] }, { "id": 6857, "title": { "de": "Predicting Cardiovascular Events Using Machine Learning", "en": "Predicting Cardiovascular Events Using Machine Learning" }, "short": "PRE-CARE ML", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2026-05-01T02:00:00+02:00", "assignment": "2021-12-21T14:20:28+01:00", "program": 112, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 3, "manager": 58906, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I5898", "ethics_committee": null, "edudract_number": null, "persons": [ "6857-58906-10" ] }, { "id": 7403, "title": { "de": "Die Rolle der Nekroptose in der akuten myeloischen Leukämie", "en": "The role of necroptosis in acute myeloid leukemia" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-01-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2023-02-16T11:30:10+01:00", "program": 207, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 1, "manager": 107132, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "SI 19/2023", "ethics_committee": null, "edudract_number": null, "persons": [ "7403-107132-10", "7403-111910-12" ] }, { "id": 6820, "title": { "de": "enFaced 2.0 - AR-Tool für die Gesichtschirurgie", "en": "enFaced 2.0 - Instant AR Tool for Maxillofacial Surgery" }, "short": "enFaced 2.0", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-04-01T02:00:00+02:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2021-12-09T10:55:12+01:00", "program": 108, "subprogram": null, "organization": 14112, "category": 10, "type": 10, "partner_function": 2, "manager": 76910, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI1044", "ethics_committee": null, "edudract_number": null, "persons": [ "6820-76910-10" ] }, { "id": 8275, "title": { "de": "Pilotstudie zum Vokalisationsverhalten von Babys mit Regulationsproblemen", "en": "Pilotstudie zum Vokalisationsverhalten von Babys mit Regulationsproblemen" }, "short": null, "url": null, "abstract": { "de": "Die Pilotstudie beschäftigt sich mit Babys mit Regulationsproblemen. Dies sind Babys, welche in den vergangenen 3 Wochen an mindestens 3 Tagen pro Woche 3 oder mehr Stunden geweint haben (\"Wessel-Kriterien\"); sie werden häufig auch als \"Schreibabys\" bezeichnet. Wissenschaftliche Studien zeigten, dass Kinder, die als Babys Regulationsprobleme hatten, später häufiger Verhaltens- und Entwicklungsauffälligkeiten haben als Kinder, die als Babys keine Regulationsprobleme hatten. Ob solche Probleme auftreten werden lässt sich im Babyalter aktuell nicht vorhersagen, zumal es bislang auch kaum Untersuchungen dazu gibt, wie sich Babys mit Regulationsproblemen – abgesehen von der Schreihäufigkeit – in den ersten Lebensmonaten verhalten. Der vorrangige Zweck dieser Pilotstudie ist es,\r\nLautäußerungen von Babys mit Regulationsproblemen und Babys ohne Regulationsprobleme im Alter von 8 bis 10 Wochen zu analysieren und erste Vergleiche anzustellen. Die Ergebnisse könnten Hinweise auf Abweichungen im vorsprachlichen Verhalten von Kindern mit Regulationsproblemen liefern. Die gewonnenen Erkenntnisse über potentiell geeignete Parameter könnten in Folgestudien dazu beitragen, Babys zu identifizieren, die ein erhöhtes Risiko für persistierende Regulationsprobleme bzw. oftmals damit einhergehende Verhaltens- und Entwicklungsdefizite haben. Die Rekrutierung für die Studie erfolgt in Zusammenarbeit mit dem Ärztlichen Dienst der Stadt Graz.", "en": null }, "begin_planned": "2024-05-01T02:00:00+02:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-06-26T16:44:08+02:00", "program": null, "subprogram": null, "organization": 14068, "category": 10, "type": 10, "partner_function": 4, "manager": 77049, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": "FIF-A 16-0451/2024-0001", "ethics_committee": null, "edudract_number": null, "persons": [ "8275-50573-12", "8275-79651-12", "8275-83581-12", "8275-91531-12", "8275-77049-10" ] }, { "id": 7333, "title": { "de": "Serologisches Antikörper Screening zu SARS-CoV-2, Legionellen und Hepatitis unter Zahnmediziner*innen 2022\r\n", "en": "Serological antibody screening for SARS-CoV-2, legionella und hepatitis among dental staf 2022" }, "short": "Leg-Hep-S22", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2023-01-16T14:19:57+01:00", "program": null, "subprogram": null, "organization": 14109, "category": 10, "type": 10, "partner_function": 4, "manager": 50051, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7333-50051-10" ] }, { "id": 8006, "title": { "de": "Sicherheit und Wirksamkeit eines mobilen, App-basierten Decision Support Systems für Bewegung bei Typ 1 Diabetes", "en": "Safety and pilot efficacy of a mobile app-based decision support system for\r\nexercise in type 1 diabetes (AppEx)" }, "short": "AppEx", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2024-01-31T15:08:01+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 50838, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 431 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8006-50838-10" ] }, { "id": 6414, "title": { "de": "Prostaglandin und Cannabinoid Rezeptoren in der EoE", "en": "Prostaglandin and cannabinoid receptors in EoE" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-01-01T01:00:00+01:00", "begin_effective": "2021-03-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2025-02-28T01:00:00+01:00", "assignment": "2021-01-18T12:19:12+01:00", "program": 108, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 56687, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI887", "ethics_committee": null, "edudract_number": null, "persons": [ "6414-56687-10" ] }, { "id": 7908, "title": { "de": "Fra-2/AP-1 induzierte Endothelzellseneszenz und ihre Rolle in der Entwicklung Sklerodermie-assoziierter Lungenerkrankungen", "en": "The role of Fra-2/AP-1 driven endothelial cell senescence in the development of scleroderma associated interstitial lung disease" }, "short": "Fra-2/AP-1 induz.Endothelzellseneszenz", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-12-01T01:00:00+01:00", "begin_effective": "2024-08-01T02:00:00+02:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2023-11-29T13:16:57+01:00", "program": null, "subprogram": null, "organization": 14006, "category": 10, "type": 10, "partner_function": 4, "manager": 61540, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 3020 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7908-61540-10" ] }, { "id": 7971, "title": { "de": "Elektrophysiologische Charakterisierung der induzierten Zellalterung zur Krebstherapie", "en": "Electrophysiological characterization of the induced senescence in cancer therapy" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-02-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2025-07-31T02:00:00+02:00", "assignment": "2024-01-16T09:27:18+01:00", "program": null, "subprogram": null, "organization": 17230, "category": 10, "type": 10, "partner_function": 2, "manager": 53900, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7971-53900-10" ] }, { "id": 6146, "title": { "de": "Vernetzte Muskelzellen bei Inkontinenz", "en": "Anchored Muscle Cells for Incontinence" }, "short": "AMELIE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-01-01T01:00:00+01:00", "begin_effective": "2020-09-01T02:00:00+02:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2020-06-02T11:14:32+02:00", "program": 109, "subprogram": null, "organization": 14063, "category": 10, "type": 10, "partner_function": 2, "manager": 51696, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": 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