Project List
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GET /v1/research/project/?format=api&offset=60&ordering=-end_effective
{ "count": 2213, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=80&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=40&ordering=-end_effective", "results": [ { "id": 9390, "title": { "de": "Second research action for medical counter measures against CBRN threats performed in the frame of the RESILIENCE FPA consortium: SP 1 - Transversal activities", "en": "Second research action for medical counter measures against CBRN threats performed in the frame of the RESILIENCE FPA consortium: SP 1 - Transversal activities" }, "short": "RESILIENCE-R-2024", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-12-01T01:00:00+01:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2028-11-30T01:00:00+01:00", "end_effective": "2028-10-31T01:00:00+01:00", "assignment": "2025-11-14T11:51:58+01:00", "program": 243, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 1, "manager": 104520, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101201953", "ethics_committee": null, "edudract_number": null, "persons": [ "9390-104520-10" ] }, { "id": 7935, "title": { "de": "European action for the Diagnosis of Early Non-symptomatic Type 1 diabetes For Intervention", "en": "European action for the Diagnosis of Early Non-symptomatic Type 1 diabetes For Intervention" }, "short": "EDENT1FI", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-11-01T01:00:00+01:00", "begin_effective": "2023-11-01T01:00:00+01:00", "end_planned": "2028-10-31T01:00:00+01:00", "end_effective": "2028-10-31T01:00:00+01:00", "assignment": "2023-12-15T12:09:06+01:00", "program": 211, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "GA101132379", "ethics_committee": null, "edudract_number": null, "persons": [ "7935-51831-10", "7935-50452-12", "7935-56667-12", "7935-81132-12", "7935-90274-12", "7935-97867-12", "7935-102575-12", "7935-109149-12" ] }, { "id": 9268, "title": { "de": "Cross Regions 4 Health", "en": "Cross Regions 4 Health" }, "short": "CrossReg-4-Health", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2028-09-30T02:00:00+02:00", "end_effective": "2028-10-30T01:00:00+01:00", "assignment": "2025-10-13T12:38:35+02:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 1, "manager": 82411, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9268-82411-10" ] }, { "id": 8761, "title": { "de": "Innovative Ansätze für die Implantationsforschung in Gesundheit und Krankheit", "en": "Innovative approaches to implantation research in health and disease" }, "short": "IMPLANTEU", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2028-09-30T02:00:00+02:00", "assignment": "2025-04-09T16:15:10+02:00", "program": 209, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 1, "manager": 53232, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101169308", "ethics_committee": null, "edudract_number": null, "persons": [ "8761-53232-10" ] }, { "id": 7791, "title": { "de": "Cluster of Excellence: Mikrobiome steuern planetare Gesundheit ", "en": "Cluster of Excellence: Microbiomes drive planetary health" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-10-01T02:00:00+02:00", "begin_effective": "2023-10-01T02:00:00+02:00", "end_planned": "2027-09-30T02:00:00+02:00", "end_effective": "2028-09-30T02:00:00+02:00", "assignment": "2023-10-02T11:21:30+02:00", "program": 125, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 50496, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "COE 7", "ethics_committee": null, "edudract_number": null, "persons": [ "7791-50496-10" ] }, { "id": 9044, "title": { "de": "OSIP: Die Erneuerung der Werkzeuge für den Planetenschutz", "en": "OSIP: Modernizing planetary protection toolkits" }, "short": null, "url": null, "abstract": { "de": "Artikel IX des Weltraumvertrags (OST) (https://www.unoosa.org/oosa/en/ourwork/spacelaw/treaties/outerspacetreaty.html) verlangt, dass die Vertragsstaaten geeignete Maßnahmen ergreifen, um eine schädliche Verunreinigung von Himmelskörpern und nachteilige Veränderungen auf der Erde zu vermeiden. Die ESA handelt im Namen ihrer Mitgliedstaaten, die alle Vertragsparteien des Weltraumvertrags sind. Als solche müssen die Aktivitäten der ESA mit den Verpflichtungen der Mitgliedstaaten gemäß Artikel IX übereinstimmen. Die derzeitigen PP-Standards, die auf den Methoden der Viking-Mission der NASA aus den 1970er Jahren beruhen, sind veraltet. Unser Verständnis von mikrobiellem Leben hat sich weiterentwickelt, und so muss auch unser Ansatz für PP. Wir schlagen ein revolutionäres Projekt im Einklang mit der PP-Vision der ESA für 2026 vor (ESA-TECQI-TN-2024-000152). Unser Ziel ist es, den Standardtest (ECSS-Q-ST-70-55) mit einem hochmodernen probabilistischen Risikobewertungsmodell zu erweitern. Jüngste Forschungsarbeiten (Green et al., 2023) haben mehrere Wissenslücken aufgedeckt, wie z. B. die Überlebensfähigkeit von PP-relevanten Mikroorganismen, die wir nun systematisch angehen wollen. Zu diesem Zweck werden wir modernste Metagenomik als Schlüsseltechnologie zur Bewertung der Biodiversität und des Risikos von Vorwärts- und Rückwärtskontaminationen einsetzen. Durch die Integration von Echtzeit-Sequenzierungstechnologien wie Nanopore können wir zeitnah (<24h) ein Profil von Umgebungen mit geringer Biomasse erstellen und den Ingenieuren ermöglichen, Maßnahmen zu ergreifen. Um die Anpassung von Mikroben an Reinraum- und Raumfahrzeugumgebungen wirklich zu verstehen, werden wir Metabolitenvorhersagen auf Genomebene und Massenspektrometrie von Proteinen und Metaboliten durchführen. Wir planen die Entwicklung eines überwachten maschinellen Lernmodells, das metagenomische und massenspektrometrische Daten nutzt, um einen risikoinformierten Wert für die Überlebensfähigkeit von Mikroben in Reinräumen und auf Oberflächen von Raumfahrzeugen zu ermitteln. Unser innovativer Ansatz wird die PP-Toolkits modernisieren, den ESA-Missionsteams mehr Flexibilität und Effizienz bei der Implementierung von PP in Industrieunternehmen bieten und gleichzeitig die Unternehmensverpflichtungen der ESA zur Durchführung verantwortungsvoller und nachhaltiger Weltraumerkundungen erfüllen. Begleiten Sie uns auf diesem kühnen Weg, PP neu zu definieren und eine sichere und nachhaltige Zukunft in der Weltraumforschung zu gewährleisten.", "en": "Article IX of the Outer Space Treaty (OST) (https://www.unoosa.org/oosa/en/ourwork/spacelaw/treaties/outerspacetreaty.html) requires that State parties adopt appropriate measures to avoid harmful contamination of celestial bodies and adverse changes on Earth. ESA acts on behalf of its Member States, all of which are State parties to the OST. As such, ESA's activities shall comply with Member States' obligations to Article IX. The current PP standards, rooted in methodologies from the 1970s NASA Viking mission, are outdated. Our understanding of microbial life has evolved, and so must our approach to PP. We propose a revolutionary project in line with ESA’s PP vision for 2026 (ESA-TECQI-TN-2024-000152). Our goal is to enhance the standard assay (ECSS-Q-ST-70-55) with a cutting-edge probabilistic risk assessment model. Recent research (Green et al., 2023) has unveiled several knowledge gaps, such as the survivability of PP-relevant microorganisms, which we aim to address now systematically. For this, we will leverage state-of-the-art metagenomics as a key technology to assess biodiversity and the risk of forward and backward contaminations. By integrating real-time sequencing technologies like Nanopore, we can profile low biomass environments in a timely manner (<24h) and allow engineers to take action. To truly understand the adaptation of microbes to cleanroom and spacecraft environments, we will implement genome-scale metabolite predictions and mass spectrometry of proteins and metabolites. We plan to develop a supervised machine learning model that uses metagenomic and mass spectrometry data to provide a risk-informed value for the survivability of microbes from cleanrooms and spacecraft surfaces. Our innovative approach will modernize PP toolkits, provide more flexibility and increased efficiency to ESA mission teams when implementing PP inside industrial organizations while fulfilling ESA’s corporate obligations to conduct responsible and sustainable space explorations. Join us in this bold journey to redefine PP and ensure a safe and sustainable future in space exploration." }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2028-09-30T02:00:00+02:00", "end_effective": "2028-09-30T02:00:00+02:00", "assignment": "2025-06-20T11:55:25+02:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 3, "manager": 100035, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1203 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9044-90021-12", "9044-100035-10", "9044-113714-12" ] }, { "id": 8926, "title": { "de": "Weiterentwicklung von genetisch codierten K+ Biosensoren", "en": "Advancing Genetically Encoded K+ Sensors for in vivo Imaging" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2027-09-30T02:00:00+02:00", "end_effective": "2028-09-30T02:00:00+02:00", "assignment": "2025-05-22T16:14:34+02:00", "program": 111, "subprogram": null, "organization": 17230, "category": 10, "type": 10, "partner_function": 4, "manager": 50810, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PIN1161824", "ethics_committee": null, "edudract_number": null, "persons": [ "8926-50810-10", "8926-130736-12", "8926-135501-12" ] }, { "id": 7792, "title": { "de": "Cluster of Excellence: Mikrobiome steuern planetare Gesundheit", "en": "Cluster of Excellence: Microbiomes drive planetary health" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-10-01T02:00:00+02:00", "begin_effective": "2023-10-01T02:00:00+02:00", "end_planned": "2028-09-30T02:00:00+02:00", "end_effective": "2028-09-30T02:00:00+02:00", "assignment": "2023-10-02T12:53:05+02:00", "program": 125, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 2, "manager": 90021, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "COE 7", "ethics_committee": null, "edudract_number": null, "persons": [ "7792-65966-12", "7792-90021-10", "7792-91470-12", "7792-95832-12", "7792-99612-12", "7792-100035-12", "7792-104024-12", "7792-109121-12", "7792-100806-12", "7792-111471-12", "7792-125318-12", "7792-129735-12", "7792-127414-12", "7792-128495-12" ] }, { "id": 9075, "title": { "de": "Search for combinational therapy to target clonal haematopoiesis in solid malignancies", "en": "Search for combinational therapy to target clonal haematopoiesis in solid malignancies" }, "short": "SARAH", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2028-08-31T02:00:00+02:00", "end_effective": "2028-09-30T02:00:00+02:00", "assignment": "2025-07-07T14:22:56+02:00", "program": 111, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 1, "manager": 109002, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PIK4391224", "ethics_committee": null, "edudract_number": null, "persons": [ "9075-109002-10", "9075-119310-12", "9075-124172-12" ] }, { "id": 9072, "title": { "de": "Bioresorbierbare Mg-Fe Implantate in der Knochenheilung", "en": "Adapting bioresorbable Mg-Fe implants in bone healing" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-07-07T13:18:31+02:00", "program": 111, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 2, "manager": 98087, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PIN5073823", "ethics_committee": null, "edudract_number": null, "persons": [ "9072-98087-10" ] }, { "id": 9082, "title": { "de": "Der Einfluss von humanen p53 Varianten auf Gewichtsschwankungs-assoziierte Metaflammation", "en": "Impact of human p53 variants on metaflammation during weight cycling" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2028-08-31T02:00:00+02:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-07-09T15:54:23+02:00", "program": 116, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 124455, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9082-124455-10" ] }, { "id": 8731, "title": { "de": "Metabolische und epigenetische Regulierung von Th9-Zellen", "en": "Metabolic and epigenetic regulation of Th9 cells" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-11-01T01:00:00+01:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2027-10-31T02:00:00+02:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-03-17T16:30:44+01:00", "program": 72, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": 78952, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT9714324", "ethics_committee": null, "edudract_number": null, "persons": [ "8731-78952-10" ] }, { "id": 9083, "title": { "de": "Metabolische Signaturen und Reaktionsvorhersage unter Nährstoffentzug bei Brustkrebs", "en": "Metabolic Signatures and Response Prediction under Nutrient Deprivation in Breast Cancer" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2028-08-31T02:00:00+02:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-07-09T16:52:51+02:00", "program": 116, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 107135, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9083-107135-10" ] }, { "id": 9128, "title": { "de": "Erweiterte Realität für offenes anatomisches und medizinisches Erbe\r\nErkundung, Innovation und kulturelle Zugänglichkeit", "en": "eXtended Reality for Open Anatomical and Medical Heritage\r\nExploration, Innovation, and Cultural Accessibility" }, "short": "XR-Anatomica", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2028-08-31T02:00:00+02:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-08-04T17:22:16+02:00", "program": null, "subprogram": "Virtuelle und hybride Welten 2024", "organization": 14018, "category": 10, "type": 10, "partner_function": 2, "manager": 97024, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9128-97024-10", "9128-102804-12" ] }, { "id": 8325, "title": { "de": "XR2ESILIENCE - BAHNBRECHENDE XR-TECHNOLOGIE ZUR FÖRDERUNG DER RESILIENZ \r\nUND DER PSYCHISCHEN GESUNDHEIT DES GESUNDHEITSPERSONALS", "en": "XR2ESILIENCE - PIONEERING XR TECHNOLOGY FOR THE PROMOTION OF RESILIENCE \r\nAND MENTAL HEALTH OF THE HEALTHCARE WORKFORCE" }, "short": "XR2ESILIENCE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-12-01T01:00:00+01:00", "begin_effective": "2024-08-01T02:00:00+02:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2028-07-31T02:00:00+02:00", "assignment": "2024-08-05T12:40:49+02:00", "program": 211, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 1, "manager": 79733, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8325-79733-10" ] }, { "id": 8142, "title": { "de": "TARgetinG disease pErsisTence and progression of\r\nMyeloProliferative Neoplasms", "en": "TARgetinG disease pErsisTence and progression of\r\nMyeloProliferative Neoplasms" }, "short": "TARGET MPN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-06-01T02:00:00+02:00", "end_planned": "2028-01-01T01:00:00+01:00", "end_effective": "2028-07-10T02:00:00+02:00", "assignment": "2024-04-18T12:35:12+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 107132, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I06944", "ethics_committee": null, "edudract_number": null, "persons": [ "8142-107132-10", "8142-134381-12", "8142-101484-12", "8142-126596-12" ] }, { "id": 4874, "title": { "de": "Analyse des RAS/MAPK-ERK Signalweges bei der akuten myeloischen Leukämie", "en": "Analysis of the RAS/MAPK-ERK signal transduction cascade in acute myeloid leukemia" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-15T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2018-04-14T02:00:00+02:00", "end_effective": "2028-06-30T02:00:00+02:00", "assignment": "2017-03-09T11:45:45+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 57402, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4874-57402-10", "4874-97430-12", "4874-108352-12", "4874-104139-12", "4874-126117-12" ] }, { "id": 8390, "title": { "de": "Intermittierendes Fasten und Bewegung bei Typ 2 Diabetes", "en": "Intermittent Fasting and Exercise in Type 2 Diabetes" }, "short": "INTERFAST-3", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-06-15T02:00:00+02:00", "begin_effective": "2024-06-15T02:00:00+02:00", "end_planned": "2027-06-14T02:00:00+02:00", "end_effective": "2028-06-14T02:00:00+02:00", "assignment": "2024-09-17T12:19:28+02:00", "program": 108, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 50838, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLP3413324", "ethics_committee": null, "edudract_number": null, "persons": [ "8390-50838-10" ] }, { "id": 8609, "title": { "de": "Exogene eletrische und mechanische Stimulation durch eletronische Haut stimuliert die Zellprofileration der oralen Mundschleimhaut", "en": "Exogenous electrical and mechanical motion stimulation by using an electronic skin for support oral cell proliferation." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-02-01T01:00:00+01:00", "begin_effective": "2025-06-01T02:00:00+02:00", "end_planned": "2028-01-31T01:00:00+01:00", "end_effective": "2028-05-31T02:00:00+02:00", "assignment": "2025-01-21T17:58:12+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 1, "manager": 133140, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "ESP6372324", "ethics_committee": null, "edudract_number": null, "persons": [ "8609-133140-10" ] }, { "id": 7529, "title": { "de": "Impfbare Krankheiten bei schwangeren und stillenden Frauen", "en": "Vaccine preventable diseases in pregnant and lactating women" }, "short": null, "url": null, "abstract": { "de": "Given its effectiveness in protecting pregnant women, foetuses and infants from infectious diseases, maternal immunization has gained interest in recent years. Nevertheless, information on the optimal timing for this vaccination strategy is limited by the relatively poor understanding of the immunobiology of vaccine responses in pregnancy and during lactation. Dynamic changes in immune function occur during gestation that may affect vaccine response in pregnant women if vaccination is given at a different timepoint in pregnancy. Additionally, since several recommendations for vaccination in pregnancy or during lactation are currently in place or being made, the question arises whether the administration of different vaccines has an impact on the induction of the antibody-mediated immune responses and whether this possibly also influence the kinetics of these vaccine-induced antibodies. This implies that repeated sampling after vaccination is needed to describe and analyse antibody kinetics. However, the design of maternal immunization studies is typically informed by generic statistical approaches not dealing with questions as to when and how often samples should be taken in order to gather the right amount of information to investigate antibody kinetics.\r\n\r\nThe objectives are 1) to describe and compare kinetics of antibodies to two different vaccines (Tdap, COVID-19) and to investigate potential interactions; 2) to develop a framework to plan maternal immunization studies.\r\n\r\nIn two ongoing trials, serum and breastmilk samples are collected at several timepoints during and after pregnancy. In the Tdap trial, three cohorts of women are included differing in gestational age at which women are vaccinated with Tdap vaccine. In the COVID-19 trial, the effects of vaccinating pregnant and lactating women with a COVID-19 vaccine are investigated. In this project, we will measure antibody titres in blood and breastmilk samples for the vaccine not being the focus of the respective trial, i.e. getting in all samples information on Tdap and COVID-19. We will use mathematical models combined with statistical tools to analyse dynamic immune response and to improve the design of maternal immunization studies.\r\n\r\nThe main innovations are:1) comparing kinetic behaviour of antibodies induced by two different vaccines on several time points in serum and breastmilk; 2) investigating potential interactions of antibodies induced by two vaccines impacting the kinetics over time; 3) development of novel methodology to analyse and plan maternal immunization studies. Within this project, we focus on pertussis and COVID-19 as examples, but outcomes of this project can be applied to other infectious diseases for which vaccines can be administered in pregnancy or during lactation.", "en": "Aufgrund der hohen Anfälligkeit von Schwangeren, Föten und Säuglingen für Infektionskrankheiten hat die Immunisierung von Müttern in den letzten Jahren an Interesse gewonnen. Dennoch ist der optimale Zeitpunkt für eine Impfung in der Schwangerschaft noch immer unbekannt. Außerdem kommt es während der Schwangerschaft zu dynamischen Veränderungen der Immunfunktion, wenn ein Impfstoff zu einem anderen Schwangerschaftsalter verabreicht wird. Dies kann die Reaktion auf den Impfstoff und die Kinetik der durch den Impfstoff induzierten mütterlichen Antikörper im Blut und in der Muttermilch der Schwangeren beeinflussen.\r\n\r\nDa derzeit mehrere Empfehlungen für Impfungen in der Schwangerschaft gelten bzw. ausgesprochen werden, stellt sich außerdem die Frage, ob die Verabreichung verschiedener Impfstoffe in der Schwangerschaft Auswirkungen auf die Immunreaktionen auf diese Impfstoffe hat und möglicherweise eine Wechselwirkung in der Kinetik der durch verschiedene Impfstoffe induzierten Antikörper verursacht.\r\n\r\nIm Rahmen dieses Projekts wollen wir den optimalen Zeitpunkt für die Impfung in der Schwangerschaft bestimmen, die Antikörperkinetik vergleichen und mögliche Wechselwirkungen bei der Immunantwort untersuchen, wenn verschiedene Impfstoffe (z. B. Pertussis, COVID-19) in der Schwangerschaft verabreicht werden. Wir entwickeln konzeptionelle Rahmen, in denen wir statistische Ansätze mit mathematischen Modellen von Infektionskrankheiten kombinieren, um die Analyse und das Design von Studien zur mütterlichen Immunisierung zu verbessern.\r\n\r\nDer Schwerpunkt des Projekts liegt auf Pertussis und COVID-19, aber die Ergebnisse können auch auf andere Infektionskrankheiten angewendet werden, gegen die Impfstoffe in der Schwangerschaft verabreicht werden können." }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-06-01T02:00:00+02:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2028-05-31T02:00:00+02:00", "assignment": "2023-04-27T14:12:52+02:00", "program": 111, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 1, "manager": 83644, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I6376", "ethics_committee": null, "edudract_number": null, "persons": [ "7529-83644-10" ] } ] }