Project List
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GET /v1/research/project/?format=api&offset=60&ordering=-begin_effective
{ "count": 2261, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=80&ordering=-begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=40&ordering=-begin_effective", "results": [ { "id": 9282, "title": { "de": "Erforschung der vielfältigen Zielwirkungen phenolreicher Formulierungen zur Verbesserung des krebshemmenden Potenzials.", "en": "Exploring the multiple target actions of phenolic-rich formulations to enhance anti-cancer potential." }, "short": "EMTAPFAP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2027-08-31T02:00:00+02:00", "end_effective": "2027-10-31T02:00:00+02:00", "assignment": "2025-11-03T11:23:00+01:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 1, "manager": 92462, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "P154_Nigeria", "ethics_committee": null, "edudract_number": null, "persons": [ "9282-92462-10" ] }, { "id": 9485, "title": { "de": "Die inflammatorische Achse kardiometabolischer Störungen in der Schwangerschaft", "en": "The Inflammatory Axis of Cardiometabolic Disorders in Pregnancy" }, "short": "Inflammatorische Achse_kardiometabolStör", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-11-01T01:00:00+01:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2025-12-15T10:33:05+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 1, "manager": 133882, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": "FIF-A 16-0069/2025-0006", "ethics_committee": null, "edudract_number": null, "persons": [ "9485-133882-10" ] }, { "id": 9223, "title": { "de": "Diethylsuccinat als neues Therapeutikum bei IPF", "en": "Diethylsuccinate as a novel therapeutic for IPF" }, "short": "Diethylsuccinat_therapeutic_IPF", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2028-09-30T02:00:00+02:00", "end_effective": "2029-10-31T01:00:00+01:00", "assignment": "2025-09-24T11:54:15+02:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 85658, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT2165825", "ethics_committee": null, "edudract_number": null, "persons": [ "9223-85658-10", "9223-50132-12", "9223-111587-12", "9223-116746-12", "9223-126994-12" ] }, { "id": 9181, "title": { "de": "Metabolische Anpassungen von Lungenkrebszellen bei Hemmung der Glykolyse", "en": "Metabolic adaptations of lung cancer cells to glycolysis inhibition" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-11-01T01:00:00+01:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2026-06-30T02:00:00+02:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2025-09-04T10:32:00+02:00", "program": 204, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 105621, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9181-105621-10" ] }, { "id": 9149, "title": { "de": "Probiotische Hefen und Nanotechnologie: Isolierung, Charakterisierung und neue Verabreichungssysteme für Gesundheits- und Lebensmittelanwendungen", "en": "Probiotic yeasts and nanotechnology: Isolation, characterization, and innovative delivery systems for health and food applications" }, "short": "PRONANO", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-01-01T01:00:00+01:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2027-10-31T02:00:00+02:00", "assignment": "2025-08-14T16:59:00+02:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 124253, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "P153", "ethics_committee": null, "edudract_number": null, "persons": [ "9149-124253-10" ] }, { "id": 9268, "title": { "de": "Cross Regions 4 Health", "en": "Cross Regions 4 Health" }, "short": "CrossReg-4-Health", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2028-09-30T02:00:00+02:00", "end_effective": "2028-10-30T01:00:00+01:00", "assignment": "2025-10-13T12:38:35+02:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 1, "manager": 82411, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9268-82411-10" ] }, { "id": 9393, "title": { "de": "Second research action for medical counter measures against CBRN threats performed in the frame of the RESILIENCE FPA consortium: SP-5 WOUNDS B-Treatment of wounds and injuries contaminated by B agents", "en": "Second research action for medical counter measures against CBRN threats performed in the frame of the RESILIENCE FPA consortium: SP-5 WOUNDS B-Treatment of wounds and injuries contaminated by B agents" }, "short": "RESILIENCE-R-2024: SP-5", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-11-01T01:00:00+01:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2028-10-31T01:00:00+01:00", "end_effective": "2028-10-31T01:00:00+01:00", "assignment": "2025-11-14T12:19:34+01:00", "program": 243, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 1, "manager": 104520, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101201953", "ethics_committee": null, "edudract_number": null, "persons": [ "9393-104520-10" ] }, { "id": 9392, "title": { "de": "Second research action for medical counter measures against CBRN threats performed in the frame of the RESILIENCE FPA consortium: SP-4 BIOMARKERS B-New biomarkers of infection by B threat agents", "en": "Second research action for medical counter measures against CBRN threats performed in the frame of the RESILIENCE FPA consortium: SP-4 BIOMARKERS B-New biomarkers of infection by B threat agents" }, "short": "RESILIENCE-R-2024: SP-4", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-11-01T01:00:00+01:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2028-10-31T01:00:00+01:00", "end_effective": "2028-10-31T01:00:00+01:00", "assignment": "2025-11-14T12:14:20+01:00", "program": 243, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 1, "manager": 104520, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101201953", "ethics_committee": null, "edudract_number": null, "persons": [ "9392-104520-10" ] }, { "id": 9298, "title": { "de": "BioTransform: Mapping des unbekannten menschlichen Stoffwechsels neuer biologischer Wirkstoffe in Lebensmitteln\r\n\r\n\r\n\r\n", "en": "BioTransform: Mapping the unchartered human metabolism for novel food bioactives\r\n" }, "short": "BioTransform", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-10-01T02:00:00+02:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2027-09-30T02:00:00+02:00", "end_effective": "2029-10-31T01:00:00+01:00", "assignment": "2025-11-05T15:18:11+01:00", "program": 209, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 2, "manager": 51266, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9298-51266-10", "9298-88711-11" ] }, { "id": 9390, "title": { "de": "Second research action for medical counter measures against CBRN threats performed in the frame of the RESILIENCE FPA consortium: SP 1 - Transversal activities", "en": "Second research action for medical counter measures against CBRN threats performed in the frame of the RESILIENCE FPA consortium: SP 1 - Transversal activities" }, "short": "RESILIENCE-R-2024", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-12-01T01:00:00+01:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2028-11-30T01:00:00+01:00", "end_effective": "2028-10-31T01:00:00+01:00", "assignment": "2025-11-14T11:51:58+01:00", "program": 243, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 1, "manager": 104520, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101201953", "ethics_committee": null, "edudract_number": null, "persons": [ "9390-104520-10" ] }, { "id": 9273, "title": { "de": "Beurteilung der Passgenauigkeit von nicht originalen Abutments bei verschraubten implantatgetragenen Brücken", "en": "Fit evaluation of nonoriginal abutments in the partial screw-retained implant-supported prosthesis on internal connection implants" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-20T02:00:00+02:00", "begin_effective": "2025-10-20T02:00:00+02:00", "end_planned": "2027-02-01T01:00:00+01:00", "end_effective": "2027-02-01T01:00:00+01:00", "assignment": "2025-10-21T18:05:25+02:00", "program": null, "subprogram": null, "organization": 14111, "category": 10, "type": 10, "partner_function": 4, "manager": 101246, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2591 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9273-101246-10" ] }, { "id": 9538, "title": { "de": "Charakterisierung von Biglykans Rolle im vaskulären Umbau und der pulmonalen arteriellen Hypertonie - Ein neuer therapeutischer Angriffspunkt?", "en": "Characterization of biglycans role in vascular remodelling and pulmonary\r\narterial hypertension – A new therapeutic target?" }, "short": "BiPAH", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-06T02:00:00+02:00", "begin_effective": "2025-10-06T02:00:00+02:00", "end_planned": "2026-10-05T02:00:00+02:00", "end_effective": "2026-10-05T02:00:00+02:00", "assignment": "2026-01-19T15:12:52+01:00", "program": null, "subprogram": null, "organization": 14006, "category": 10, "type": 10, "partner_function": 3, "manager": 114963, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9538-114963-10" ] }, { "id": 9255, "title": { "de": "Präziseres Therapiemonitoring dank blutbasierter Biomarker", "en": "It’s in our blood: Improving cancer treatment monitoring via liquid biomarkers" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2025-08-31T02:00:00+02:00", "end_effective": "2027-09-30T02:00:00+02:00", "assignment": "2025-10-06T13:24:38+02:00", "program": null, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 4, "manager": 76215, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9255-76215-10" ] }, { "id": 8926, "title": { "de": "Weiterentwicklung von genetisch codierten K+ Biosensoren", "en": "Advancing Genetically Encoded K+ Sensors for in vivo Imaging" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2027-09-30T02:00:00+02:00", "end_effective": "2029-09-30T02:00:00+02:00", "assignment": "2025-05-22T16:14:34+02:00", "program": 111, "subprogram": null, "organization": 17230, "category": 10, "type": 10, "partner_function": 4, "manager": 50810, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PIN1161824", "ethics_committee": null, "edudract_number": null, "persons": [ "8926-50810-10", "8926-130736-12", "8926-135501-12" ] }, { "id": 9044, "title": { "de": "OSIP: Die Erneuerung der Werkzeuge für den Planetenschutz", "en": "OSIP: Modernizing planetary protection toolkits" }, "short": null, "url": null, "abstract": { "de": "Artikel IX des Weltraumvertrags (OST) (https://www.unoosa.org/oosa/en/ourwork/spacelaw/treaties/outerspacetreaty.html) verlangt, dass die Vertragsstaaten geeignete Maßnahmen ergreifen, um eine schädliche Verunreinigung von Himmelskörpern und nachteilige Veränderungen auf der Erde zu vermeiden. Die ESA handelt im Namen ihrer Mitgliedstaaten, die alle Vertragsparteien des Weltraumvertrags sind. Als solche müssen die Aktivitäten der ESA mit den Verpflichtungen der Mitgliedstaaten gemäß Artikel IX übereinstimmen. Die derzeitigen PP-Standards, die auf den Methoden der Viking-Mission der NASA aus den 1970er Jahren beruhen, sind veraltet. Unser Verständnis von mikrobiellem Leben hat sich weiterentwickelt, und so muss auch unser Ansatz für PP. Wir schlagen ein revolutionäres Projekt im Einklang mit der PP-Vision der ESA für 2026 vor (ESA-TECQI-TN-2024-000152). Unser Ziel ist es, den Standardtest (ECSS-Q-ST-70-55) mit einem hochmodernen probabilistischen Risikobewertungsmodell zu erweitern. Jüngste Forschungsarbeiten (Green et al., 2023) haben mehrere Wissenslücken aufgedeckt, wie z. B. die Überlebensfähigkeit von PP-relevanten Mikroorganismen, die wir nun systematisch angehen wollen. Zu diesem Zweck werden wir modernste Metagenomik als Schlüsseltechnologie zur Bewertung der Biodiversität und des Risikos von Vorwärts- und Rückwärtskontaminationen einsetzen. Durch die Integration von Echtzeit-Sequenzierungstechnologien wie Nanopore können wir zeitnah (<24h) ein Profil von Umgebungen mit geringer Biomasse erstellen und den Ingenieuren ermöglichen, Maßnahmen zu ergreifen. Um die Anpassung von Mikroben an Reinraum- und Raumfahrzeugumgebungen wirklich zu verstehen, werden wir Metabolitenvorhersagen auf Genomebene und Massenspektrometrie von Proteinen und Metaboliten durchführen. Wir planen die Entwicklung eines überwachten maschinellen Lernmodells, das metagenomische und massenspektrometrische Daten nutzt, um einen risikoinformierten Wert für die Überlebensfähigkeit von Mikroben in Reinräumen und auf Oberflächen von Raumfahrzeugen zu ermitteln. Unser innovativer Ansatz wird die PP-Toolkits modernisieren, den ESA-Missionsteams mehr Flexibilität und Effizienz bei der Implementierung von PP in Industrieunternehmen bieten und gleichzeitig die Unternehmensverpflichtungen der ESA zur Durchführung verantwortungsvoller und nachhaltiger Weltraumerkundungen erfüllen. Begleiten Sie uns auf diesem kühnen Weg, PP neu zu definieren und eine sichere und nachhaltige Zukunft in der Weltraumforschung zu gewährleisten.", "en": "Article IX of the Outer Space Treaty (OST) (https://www.unoosa.org/oosa/en/ourwork/spacelaw/treaties/outerspacetreaty.html) requires that State parties adopt appropriate measures to avoid harmful contamination of celestial bodies and adverse changes on Earth. ESA acts on behalf of its Member States, all of which are State parties to the OST. As such, ESA's activities shall comply with Member States' obligations to Article IX. The current PP standards, rooted in methodologies from the 1970s NASA Viking mission, are outdated. Our understanding of microbial life has evolved, and so must our approach to PP. We propose a revolutionary project in line with ESA’s PP vision for 2026 (ESA-TECQI-TN-2024-000152). Our goal is to enhance the standard assay (ECSS-Q-ST-70-55) with a cutting-edge probabilistic risk assessment model. Recent research (Green et al., 2023) has unveiled several knowledge gaps, such as the survivability of PP-relevant microorganisms, which we aim to address now systematically. For this, we will leverage state-of-the-art metagenomics as a key technology to assess biodiversity and the risk of forward and backward contaminations. By integrating real-time sequencing technologies like Nanopore, we can profile low biomass environments in a timely manner (<24h) and allow engineers to take action. To truly understand the adaptation of microbes to cleanroom and spacecraft environments, we will implement genome-scale metabolite predictions and mass spectrometry of proteins and metabolites. We plan to develop a supervised machine learning model that uses metagenomic and mass spectrometry data to provide a risk-informed value for the survivability of microbes from cleanrooms and spacecraft surfaces. Our innovative approach will modernize PP toolkits, provide more flexibility and increased efficiency to ESA mission teams when implementing PP inside industrial organizations while fulfilling ESA’s corporate obligations to conduct responsible and sustainable space explorations. Join us in this bold journey to redefine PP and ensure a safe and sustainable future in space exploration." }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2028-09-30T02:00:00+02:00", "end_effective": "2028-09-30T02:00:00+02:00", "assignment": "2025-06-20T11:55:25+02:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 3, "manager": 100035, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1203 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9044-90021-12", "9044-100035-10", "9044-113714-12" ] }, { "id": 9139, "title": { "de": "HER2-gerichteter M13-Bakteriophage als Träger für TRAIL zur gezielten Therapie von Brustkrebs", "en": "Targeted TRAIL delivery via HER2-specific M13 bacteriophage for breast cancer therapy" }, "short": "PHANTHER", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2027-09-30T02:00:00+02:00", "end_effective": "2027-09-30T02:00:00+02:00", "assignment": "2025-08-07T12:17:54+02:00", "program": 203, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 124253, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "ASEA 29/2025", "ethics_committee": null, "edudract_number": null, "persons": [ "9139-124253-10" ] }, { "id": 9270, "title": { "de": "Strukturiertes Kommunikationstraining mit standardisierten Patient*innen für die antenatale neonatologische Beratung bei drohender Frühgeburt", "en": "Antenatal Counselling Training for expected preterm delivery using structured communication training with standardized patients" }, "short": "ACT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2025-10-15T18:28:23+02:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 1, "manager": 68534, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 97 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9270-68534-10" ] }, { "id": 9014, "title": { "de": "Elemental and Structural Composition underlying Brain MRI", "en": "Elemental and Structural Composition underlying Brain MRI" }, "short": "WhatsMRI", "url": null, "abstract": { "de": "Magnetic Resonance Imaging (MRI) is widely established, with 50,000 scanners worldwide and more than100 million diagnostic scans conducted yearly. Myelin acts as the electrical insulation of neuronal fibers andis essential for motor, sensory, and cognitive functions and is composed of several lipids and proteins arrangedin a specific geometry. However, myelin loss occurs regionally in inflammatory diseases like multiplesclerosis, myelitis, and optic neuritis, and it also serves as a biomarker of aging.Despite the availability of various MRI-based approaches for detecting myelin, there remains a significant gapin systematically validated knowledge regarding how myelin's lipids, proteins, and structural variationsinfluence MRI signal generation. Furthermore, there is no gold standard for assessing the constituents ofmyelin, and conclusions are primarily based on MRI of formalin-fixed tissue.Quantitative post-mortem MRI of unfixed human brains in situ, combined with subsequent mass spectrometryimaging (LA-ICP-TOF-MS, MALDI-MSI), small-angle X-ray scattering (SAXS), and microscopy (CARS,TEM, IHC), will enable histologically enriched modelling of tissue and the simulation of fundamental MRIparameters (relaxometry, susceptibility, and diffusion) to reveal causal relationships with chemical elements,matrix composition, structure, and common molecules of myelin, neural fiber orientation, and biometals. Inaddition to 20 control brains, 10 brains from deceased individuals with multiple sclerosis will be recruited tobroaden the spectrum of myelination under investigation.This research addresses the fundamental biophysical mechanisms underlying MRI of myelin and chemicalelements, which currently lack validation. We will establish a publicly available elemental and histochemicalatlas of the human brain and identify how histological features causally contribute to quantitative MRIparameters.", "en": "Magnetic Resonance Imaging (MRI) is widely established, with 50,000 scanners worldwide and more than100 million diagnostic scans conducted yearly. Myelin acts as the electrical insulation of neuronal fibers andis essential for motor, sensory, and cognitive functions and is composed of several lipids and proteins arrangedin a specific geometry. However, myelin loss occurs regionally in inflammatory diseases like multiplesclerosis, myelitis, and optic neuritis, and it also serves as a biomarker of aging.Despite the availability of various MRI-based approaches for detecting myelin, there remains a significant gapin systematically validated knowledge regarding how myelin's lipids, proteins, and structural variationsinfluence MRI signal generation. Furthermore, there is no gold standard for assessing the constituents ofmyelin, and conclusions are primarily based on MRI of formalin-fixed tissue.Quantitative post-mortem MRI of unfixed human brains in situ, combined with subsequent mass spectrometryimaging (LA-ICP-TOF-MS, MALDI-MSI), small-angle X-ray scattering (SAXS), and microscopy (CARS,TEM, IHC), will enable histologically enriched modelling of tissue and the simulation of fundamental MRIparameters (relaxometry, susceptibility, and diffusion) to reveal causal relationships with chemical elements,matrix composition, structure, and common molecules of myelin, neural fiber orientation, and biometals. Inaddition to 20 control brains, 10 brains from deceased individuals with multiple sclerosis will be recruited tobroaden the spectrum of myelination under investigation.This research addresses the fundamental biophysical mechanisms underlying MRI of myelin and chemicalelements, which currently lack validation. We will establish a publicly available elemental and histochemicalatlas of the human brain and identify how histological features causally contribute to quantitative MRIparameters." }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2030-01-01T01:00:00+01:00", "end_effective": "2030-09-30T02:00:00+02:00", "assignment": "2025-06-10T15:39:19+02:00", "program": 208, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 3, "manager": 60116, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9014-70759-11", "9014-86408-11", "9014-98541-12", "9014-101162-11", "9014-60116-10", "9014-118667-12", "9014-132017-12", "9014-134821-12", "9014-135321-12", "9014-135543-12", "9014-127954-12" ] }, { "id": 9299, "title": { "de": "Prädiktive Marker und Pathomechanismen der Krankheitsprogression bei Mycosis fungoides", "en": "Predictive markers and pathomechanisms of mycosis fungoides disease progression: Integrating Spatial Transcriptomics and In Situ Analysis of archived FFPE samples" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2027-09-30T02:00:00+02:00", "assignment": "2025-11-06T09:08:00+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 118468, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1161 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9299-118468-10" ] }, { "id": 9075, "title": { "de": "Search for combinational therapy to target clonal haematopoiesis in solid malignancies", "en": "Search for combinational therapy to target clonal haematopoiesis in solid malignancies" }, "short": "SARAH", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2028-08-31T02:00:00+02:00", "end_effective": "2028-09-30T02:00:00+02:00", "assignment": "2025-07-07T14:22:56+02:00", "program": 111, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 1, "manager": 109002, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PIK4391224", "ethics_committee": null, "edudract_number": null, "persons": [ "9075-109002-10", "9075-119310-12", "9075-124172-12" ] } ] }