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GET /v1/research/project/?format=api&offset=60&ordering=-begin_effective
{ "count": 2140, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=80&ordering=-begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=40&ordering=-begin_effective", "results": [ { "id": 8412, "title": { "de": "Immunologische Evaluierung des pre-Sjögren Syndromes", "en": "Pre-Sjögren Syndrome Targeted Immunology \r\nEvaluation – The preSStige study" }, "short": "preSStige", "url": null, "abstract": { "de": "Die Sjögren Erkrankung (auch primäres Sjögren-Syndrom genannt) ist eine Autoimmunerkrankung, bei der das körpereigene Immunsystem die Speichel- und Tränendrüsen angreift und zerstört. Seltener können auch lebenswichtige Organe befallen sein. Die Erkrankung verläuft häufig schleichend weswegen sie meist sehr spät erkannt wird. Daher stammt der größte Teil des derzeitigen Wissens über die Sjögren Erkrankung von Patient*innen mit langjähriger Erkrankung. Die Symptome der Patient*innen im Frühstadium der Erkrankung, die initialen immunologischen Veränderungen und die frühen Veränderungen der Speichel- und Tränendrüsen sind völlig unbekannt. Daher gibt es derzeit auch keine Biomarker für die Frühdiagnose der Sjögren Erkrankung. Das vorliegende Projekt ist eine Zusammenarbeit zwischen universitären Zentren in Graz (Österreich) und Brest (Frankreich) und zielt darauf ab, die anfänglichen immunologischen Veränderungen der Sjögren Erkrankung aufzudecken und so die Entstehung der Erkrankung besser zu verstehen. \r\nUm dieses Ziel zu erreichen werden im vorliegenden Projekt etwa 140 Menschen mit hohem Risiko für die Entwicklung einer Sjögren Erkrankung über mehrere Jahre begleitet und eingehend untersucht. Die Methodik verbindet klinische Forschung mit modernsten Labortechniken. Mit Hilfe fortschrittlicher Instrumente werden im Rahmen der Studie eingehende Profile des Immunsystems erstellt. Techniken wie die Einzelzell-RNA-Sequenzierung und Einsatz künstlicher Intelligenz zur Diagnosevorhersage sind integrale Bestandteile des innovativen Forschungsansatzes. Mithilfe der gewonnenen Daten können immunologische Veränderungen von Studienteilnehmer*innen, die im Laufe des Beobachtungszeitraumes eine Sjögren Erkrankung entwickeln, exakt identifiziert und eingeordnet werden. Diese Erkenntnisse sollen das Verständnis zur Entstehung und die Früherkennung der Sjögren Erkrankung revolutionieren.\r\n\r\n", "en": "Sjögren's disease (also known as primary Sjögren's syndrome) is an autoimmune disease in which the body's own immune system attacks and destroys the salivary and lacrimal glands. Vital organs such as the kidneys and lungs can also be affected. The disease often progresses insidiously, which is why it is usually diagnosed very late. It is therefore clear that the majority of current knowledge about Sjögren's disease is derived from patients who have had the disease for many years. In contrast, we know little about the initial immunological events, the symptoms of patients in the early stages of the disease or the early changes in the salivary and lacrimal glands. This means that there are currently no biomarkers for the early diagnosis of Sjögren's disease. This project is a collaboration between university centres in Graz (Austria) and Brest (France). Its aim is to uncover the initial immunological changes of Sjögren's disease in order to better understand the pathogenesis of the disease. \r\nWe will achieve this goal by following and examining in detail around 140 participants at high risk of developing Sjögren's disease over several years. The methodology combines clinical research with state-of-the-art laboratory techniques. The study will create detailed profiles of the immune system using advanced instruments. Techniques such as single-cell RNA sequencing and the use of artificial intelligence for diagnosis prediction are fundamental to this innovative research approach. The data obtained will precisely identify and classify immunological changes in study participants who develop Sjögren's disease during the observation period. These findings will transform our understanding of the development and early diagnosis of Sjögren's disease.\r\n" }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2029-12-31T01:00:00+01:00", "end_effective": "2029-12-31T01:00:00+01:00", "assignment": "2024-10-02T16:37:19+02:00", "program": 111, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 3, "manager": 53560, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PIN3316924", "ethics_committee": null, "edudract_number": null, "persons": [ "8412-51002-12", "8412-53560-10", "8412-85048-12", "8412-111407-12", "8412-105947-12", "8412-120209-12", "8412-108758-12", "8412-101167-12", "8412-120630-12" ] }, { "id": 8534, "title": { "de": "K Kanal Regler bei IPF\r\n", "en": "K channel regulator in IPF\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2028-12-31T01:00:00+01:00", "end_effective": "2028-12-31T01:00:00+01:00", "assignment": "2024-11-28T16:37:05+01:00", "program": 72, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 58984, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT7985824", "ethics_committee": null, "edudract_number": null, "persons": [ "8534-58984-10" ] }, { "id": 8425, "title": { "de": "Nanoträger für die selektive Behandlung von HER2+ Brustkrebs", "en": "Nanocarriers for selective HER2+ breast cancer treatment" }, "short": "MIP-Magic", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-03-31T02:00:00+02:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2024-10-07T16:23:56+02:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 3, "manager": 124253, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8425-124253-10" ] }, { "id": 8645, "title": { "de": "Bile acids ameliorate obesogenic memory", "en": "Bile acids ameliorate obesogenic memory" }, "short": "BAOB", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2025-02-10T15:52:55+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 98847, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8645-98847-10" ] }, { "id": 8572, "title": { "de": "Biologische Chelatbildner zur Behandlung von Metallionenüberladung: Eine vergleichende Studie mit traditionellen chemischen Chelatoren", "en": "Biological chelation agents for metal ion overload: A comparative study\r\nwith traditional chemical chelators" }, "short": "Bio-Chem-Chel ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-12-19T14:55:05+01:00", "program": 203, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 3, "manager": 124253, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "ASEA 11/2024", "ethics_committee": null, "edudract_number": null, "persons": [ "8572-124253-10" ] }, { "id": 8573, "title": { "de": "Integrierter Ansatz zur Gewebsheilung: Ein bioaktives magnetisches Pflaster mit Hyperthermie und immobilisiertem Humanserumalbumin", "en": "Integrative approach to tissue healing: A bioactive magnetic patch with hyperthermia and immobilized human serum albumin" }, "short": "BIMA-Patch", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-12-19T15:25:02+01:00", "program": 207, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 124253, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "BA 07/2025", "ethics_committee": null, "edudract_number": null, "persons": [ "8573-124253-10" ] }, { "id": 8299, "title": { "de": "Energetik-Transkriptions Kopplung im hypertensiven Herzen", "en": "Energetics-transcription coupling in hypertensive heart" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2029-12-31T01:00:00+01:00", "end_effective": "2029-12-31T01:00:00+01:00", "assignment": "2024-07-17T18:19:55+02:00", "program": 110, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 62747, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "STA 194", "ethics_committee": null, "edudract_number": null, "persons": [ "8299-62747-10", "8299-75758-12", "8299-117943-12", "8299-122231-12", "8299-110709-12", "8299-105142-12" ] }, { "id": 8558, "title": { "de": "Teaching students how children with neurodevelopmental disorders adopt and interact with technologies", "en": "Teaching students how children with neurodevelopmental disorders adopt and interact with technologies" }, "short": "TE(A)CHADOPT", "url": null, "abstract": { "de": "Technologien spielen eine immer größer werdende Rolle im Alltag von Kindern mit Entwicklungsstörungen. So werden sie beispielsweise zu Therapiezwecken und als Kommunikationshilfen eingesetzt. Vielfach ist die Barrierefreiheit von Technologien für Kinder mit Entwicklungsstörungen jedoch nicht ausreichend gegeben. Zugleich wird dieses Thema in der Ausbildung derjenigen Studierenden, die in ihrem Berufsleben später Technologien (mit-)entwickeln und/oder einsetzen werden noch kaum behandelt. Im Rahmen dieses interdisziplinären Kooperationsprojekts von sieben Institutionen aus sechs Ländern sollen Leitlinien zur Evaluation von Technologien hinsichtlich ihrer Barrierefreiheit für Kinder mit Entwicklungsstörungen entwickelt und ein umfangreiches Lehrmaterial erstellt, eingesetzt und verbreitet werden. TE(A)CHADOPT soll dazu beitragen, dass Technologien künftig besser die Wünsche und Bedürfnisse von Kindern mit Entwicklungsstörungen erfüllen.", "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-12-15T01:00:00+01:00", "end_planned": "2027-09-30T02:00:00+02:00", "end_effective": "2027-12-14T01:00:00+01:00", "assignment": "2024-12-12T12:09:30+01:00", "program": 220, "subprogram": null, "organization": 14068, "category": 10, "type": 10, "partner_function": 3, "manager": 77049, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "2024-1-AT01-KA220-HED-000248380", "ethics_committee": null, "edudract_number": null, "persons": [ "8558-77049-10", "8558-125014-12" ] }, { "id": 8591, "title": { "de": "Krebsbekämpfung mit digitaler Pathologie ", "en": "Fighting cancer with digital pathology" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-09-01T02:00:00+02:00", "begin_effective": "2024-12-01T01:00:00+01:00", "end_planned": "2026-08-31T02:00:00+02:00", "end_effective": "2026-11-30T01:00:00+01:00", "assignment": "2025-01-14T13:06:19+01:00", "program": 206, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 104839, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8591-104839-10" ] }, { "id": 8530, "title": { "de": "Krebsbekämpfung mit digitaler Pathologie ", "en": "Fighting cancer with digital pathology " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": null, "begin_effective": "2024-12-01T01:00:00+01:00", "end_planned": null, "end_effective": "2026-11-30T01:00:00+01:00", "assignment": "2024-11-26T10:47:29+01:00", "program": 206, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 92422, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8530-92422-10" ] }, { "id": 8538, "title": { "de": "Mikrobielle Kontaminationen im Tränkewassersystem – Zusammenhang mit Absetzdurchfällen in der Schweinehaltung ", "en": "Microbial contamination in the drinking water pipe system – correlation with post weaning diarrhea in pig farming" }, "short": "MikroWaSta", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-11-01T01:00:00+01:00", "begin_effective": "2024-12-01T01:00:00+01:00", "end_planned": "2027-04-30T02:00:00+02:00", "end_effective": "2027-04-30T02:00:00+02:00", "assignment": "2024-12-03T15:10:53+01:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 58733, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 957 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8538-50497-11", "8538-51198-11", "8538-58733-10", "8538-103077-12" ] }, { "id": 8459, "title": { "de": "Succinat als Signalmolekül in der menschlichen Plazenta", "en": "Succinate as Signaling Molecule in the human Placenta" }, "short": "Succinat_Signalmolekül_menschlPlazenta", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2024-12-01T01:00:00+01:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2027-11-30T01:00:00+01:00", "assignment": "2024-10-21T11:54:18+02:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 51756, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT8808224", "ethics_committee": null, "edudract_number": null, "persons": [ "8459-51756-10", "8459-100879-11", "8459-111587-12" ] }, { "id": 8445, "title": { "de": "Wissenschaftspreis der ÖGKJ", "en": "Research Prize of the \"ÖGKJ\"" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-11-01T01:00:00+01:00", "begin_effective": "2024-11-01T01:00:00+01:00", "end_planned": "2027-10-31T02:00:00+02:00", "end_effective": "2027-10-31T02:00:00+02:00", "assignment": "2024-10-15T14:31:21+02:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 3, "manager": 50907, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 97 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8445-50907-10" ] }, { "id": 8503, "title": { "de": "„Mikroperfusion der Haut zur Bestimmung von Veränderungen des Mikromilieus der Haut bei SSc“", "en": "Dermal open flow microperfusion to determine changes in the skin microenvironment in vivo during SSc" }, "short": "SSc_OFM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-11-01T01:00:00+01:00", "begin_effective": "2024-11-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-11-19T13:55:23+01:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 1, "manager": 120271, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2296 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8503-120271-10" ] }, { "id": 8370, "title": { "de": "pan-European Management of Biological toxin incidents through standaRdisAtion initiatives for Crisis response Enhancement (EMBRACE)", "en": "pan-European Management of Biological toxin incidents through standaRdisAtion initiatives for Crisis response Enhancement (EMBRACE)" }, "short": "EMBRACE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2027-09-30T02:00:00+02:00", "end_effective": "2027-09-30T02:00:00+02:00", "assignment": "2024-08-22T12:04:16+02:00", "program": 211, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 2, "manager": 50654, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8370-50654-10" ] }, { "id": 8525, "title": { "de": "Metabolische Kontrolle von Altern und Krankheit", "en": "Metabolic control of aging and disease" }, "short": "MetAGE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2028-09-30T02:00:00+02:00", "end_effective": "2029-09-30T02:00:00+02:00", "assignment": "2024-11-21T16:12:41+01:00", "program": 125, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51860, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "COE14", "ethics_committee": null, "edudract_number": null, "persons": [ "8525-51860-10", "8525-70922-12", "8525-124053-12", "8525-120872-12" ] }, { "id": 8127, "title": { "de": "LYVE-1 Hofbauer-Zellen bei Präeklampsie", "en": "LYVE-1 Hofbauer cells in preeclampsia" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-03-01T01:00:00+01:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2027-02-28T01:00:00+01:00", "end_effective": "2027-09-30T02:00:00+02:00", "assignment": "2024-04-05T10:35:43+02:00", "program": 111, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 53232, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I06907", "ethics_committee": null, "edudract_number": null, "persons": [ "8127-53232-10", "8127-98902-12", "8127-93683-12", "8127-90214-12", "8127-119494-12", "8127-126134-12", "8127-106163-12" ] }, { "id": 8356, "title": { "de": "CXCR4 role in the anabolic response of teriparatide in bone ", "en": "CXCR4 role in the anabolic response of teriparatide in bone " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2028-03-31T02:00:00+02:00", "end_effective": "2028-03-31T02:00:00+02:00", "assignment": "2024-08-19T14:37:04+02:00", "program": 72, "subprogram": null, "organization": 14028, "category": 10, "type": 10, "partner_function": 4, "manager": 107134, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT4629323", "ethics_committee": null, "edudract_number": null, "persons": [ "8356-50464-12", "8356-56571-12", "8356-122433-12", "8356-124131-12", "8356-129458-12", "8356-107134-10", "8356-110967-12" ] }, { "id": 8312, "title": { "de": "Studying TRPC6 conformational dynamics with high-speed atomic force microscopy", "en": "Untersuchung der Konformationsdynamik von TRPC6 mit Hochgeschwindigkeits-Atomkraftmikroskopie" }, "short": null, "url": null, "abstract": { "de": "Transient-Rezeptor-Potential-Kanäle vom kanonischen Typ (TRPC) sind kalziumdurchlässige Ionenkanäle, die sowohl in erregbaren als auch in nicht-erregbaren Zellen vorkommen. TRPC-Kanäle werden durch Diacylglycerol (DAG) aktiviert, ein Produkt, das im Phospholipase-C-(PLC)-Weg nach der Spaltung von Phosphatidylinositol-4,5-bisphosphat (PIP2) gebildet wird. Bemerkenswerterweise sind, obwohl alle TRPC-Kanäle an (patho)physiologischen Prozessen beteiligt sind, nur TRPC6 als ein Schlüsselfaktor in der Entwicklung einer schweren Nierenerkrankung bekannt, die als fokal segmentale Glomerulosklerose (FSGS) bezeichnet wird. FSGS ist durch einen kontinuierlichen Kalziumleckstrom durch TRPC6 gekennzeichnet, der das Ionen-Gleichgewicht in den glomerulären Zellen stört und letztendlich zu einer Glomerulosklerose führt. Jüngste kryo-elektronenmikroskopische (Kryo-EM) Studien von TRPC6 konnten nur Strukturen von geschlossenen Kanälen erfassen und geben keine Einblicke in die Dynamik des Kanalöffnungsmechanismus, selbst in Anwesenheit von Aktivatoren. Ein Verständnis des Öffnungsmechanismus des TRPC6-Kanals zu gewinnen, wird jedoch unser Verständnis seiner pathophysiologischen Bedeutung erweitern. Darüber hinaus wird es die Grundlage für die Entwicklung pharmakologischer Strategien zur Regulierung des Kanals in nativen Geweben schaffen. Elektrophysiologische Analysen des TRPC6-Verhaltens auf Einzelkanalebene zeigten einen kurzlebigen geöffneten Zustand des Kanals. Folglich vermuten wir, dass das Kanalverhalten das Haupthindernis beim Verständnis des Öffnungsmechanismus von TRPC6-Kanälen in Kryo-EM-Studien darstellt. Hochgeschwindigkeits-Atomkraftmikroskopie (HS-AFM), eine hochmoderne Technik, hat in den letzten Jahren insbesondere bei der Untersuchung der Kanalöffnungsmechanismen von Ionenkanälen viel Aufmerksamkeit erlangt. Diese Technik ermöglicht hochauflösende und zeitlich aufgelöste topografische Bilder einer Probe, indem ihre Oberfläche gescannt wird. Kürzlich hat die Gruppe von Prof. Dr. Scheuring erfolgreich HS-AFM eingesetzt, um die Dynamik in den TRPV2- und TRPV3-Kanälen zu untersuchen. Um ein umfassendes Verständnis von TRPC6 zu erlangen und das Verhalten des Kanals in nativem Gewebe zu verstehen, werden wir die Dynamik des Kanalöffnungsmechanismus nach Stimulation mit verschiedenen Agonisten unter Verwendung von HS-AFM untersuchen.", "en": "Transient receptor potential canonical (TRPC) channels are calcium permeable ion channels found both in excitable and non-excitable cells. TRPC channels are activated by diacylglycerol (DAG), a product generated in the phospholipase C (PLC) pathway following the cleavage of phosphatidylinositol 4,5-bisphosphate (PIP2). Notably, although all TRPC channels are involved in (patho)physiological processes, only TRPC6 has been identified as playing a pivotal role in the development of a severe kidney disease known as focal segmental glomerulosclerosis (FSGS). FSGS is characterized by continuous calcium leakage through TRPC6, which disturbs ion homeostasis within glomerular cells, ultimately resulting in glomerular sclerosis. Recent cryo-electron microscopy (cryo-EM) studies of TRPC61–3 could obtain only closed-channel structures and do not give insights into the dynamics of channel gating even in presence of activators. However, gaining an understanding of the gating mechanism of the TRPC6 channel will enhance our comprehension of its pathophysiological significance. Furthermore, it will establish a foundation for developing pharmacological strategies to regulate the channel within native tissues. Electrophysiological analysis of TRPC6 behavior on a single channel level showed a short-lived open state of the channel.4 Consequently, we hypothesized that the channel behavior is the main obstacle in gaining insights into the gating mechanism of TRPC6 channels during cryo-EM. High-speed atomic force microscopy (HS-AFM), a state-of-the-art technique, has gained high attention in recent years especially in studying ion channel gating. This technique allows high-resolution and time resolved topographic images of a sample by scanning its surface. Recently the group of Prof. Dr. Scheuring, successfully employed HS-AFM to study the dynamics in TRPV25 and TRPV36 ion channels. To gain a comprehensive understanding of TRPC6 and understand the behavior of the channel in native tissue we will study the dynamics of channel gating upon stimulation with different agonists using HS-AFM. " }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2026-09-30T02:00:00+02:00", "end_effective": "2026-09-30T02:00:00+02:00", "assignment": "2024-07-26T11:43:41+02:00", "program": 116, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 116421, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8312-73077-12", "8312-78591-12", "8312-90337-12", "8312-98848-12", "8312-116421-10" ] }, { "id": 8395, "title": { "de": "Identifying novel lung cancer drivers: Unravelling the functional role of genes affected by large copy number gains\r\n", "en": "Identifying novel lung cancer drivers: Unravelling the functional role of genes affected by large copy number gains\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-09-23T13:30:15+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 109002, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1888 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8395-98327-12", "8395-109002-10", "8395-109501-11", "8395-111070-11" ] } ] }