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GET /v1/research/project/?format=api&offset=560&ordering=end_effective
{ "count": 2245, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=580&ordering=end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=540&ordering=end_effective", "results": [ { "id": 2941, "title": { "de": "Kognition bei bipolar affektiver Störung", "en": "cognitive function in bipolar disorder" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-09-01T02:00:00+02:00", "end_planned": "2012-05-01T02:00:00+02:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2012-08-13T15:51:24+02:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2896, "title": { "de": "Transport von mütterlichem Serotonin über die humane Plazenta: Studien an primären Endothezellen der menschlichen Plazenta", "en": "Transport of Maternal Serotonin across Human Placenta: studies on primary endothelial cells of human placental barrier" }, "short": "Transport of Maternal Serotonin", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-01-01T01:00:00+01:00", "begin_effective": "2012-01-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2012-06-21T11:08:07+02:00", "program": 92, "subprogram": "WTZ-Kroatien", "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2896-50442-12" ] }, { "id": 2076, "title": { "de": "Identifikation von neuen Biomarkern und ß-Zellantigenen bei PatientInnen mit Typ 1 Diabetes und deren Verwandten ersten Grades: Stufe 1 des Österreichischen Diabetes Präventions-Programmes (ADPP-001)", "en": "Identification of new biomarkers an ß cell antigens in type 1 diabetic subjects and their first-degree relatives: Step 1 of the Austrian Diabetes Prevention Programme (ADPP-001)" }, "short": "ADPP-001", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2010-02-04T16:37:59+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 51831, "contact": 51831, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 984 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2076-51831-10", "2076-50551-12", "2076-67348-12", "2076-76349-12" ] }, { "id": 3226, "title": { "de": "Von Hypertrophie zur Herzinsuffizienz-die Rolle des spontanen SR Ca2+ Lecks", "en": "From hypertrophy to heart failure-the role of spontaneous SR Ca2+ leak" }, "short": "MUG Start", "url": null, "abstract": { "de": null, "en": "Heart failure (HF) is a leading cause of death in the developed countries. Despite considerable progress in the past decade in our understanding of cellular and molecular mechanisms involved in the progression of HF, therapeutic agents that specifically target the underlying cellular defects remain rare and ineffective. In HF, intracellular Ca2+ homeostasis is altered and increased cytosolic Ca2+ has been proposed as a potential activator of hypertrophic signalling cascades, ultimately culminating in overt HF phenotype. Recent studies pointed out that increased spontaneous Ca2+ release (Ca2+ leak) from the sarcoplasmic reticulum (SR) Ca2+ release channel (ryanodine receptor, RyR2) due to defective regulation of the RyR2 occurs during HF and causes contractile dysfunction and development of arrhythmias. However, it remains controversial whether increased SR Ca2+ leak is an epiphenomenon accompanying HF only or a pathophysiologically relevant process contributing to accelerated decompensation from hypertrophy to HF.\r\nIn the proposed project, we will pursue the hypothesis, that an increased spontaneous SR Ca2+ leak per se is causally involved in accelerated decompensation from cardiac hypertrophy to HF. We will take advantage of the minimally invasive transverse aortic constriction (TAC) as a pressure overload model for HF, and apply it to a mouse model with an inherited SR Ca2+ leak (knock-in RyR2R4496C+/- human mutation). Our preliminary results show strikingly increased hypertrophy and accelerated transition from hypertrophy to HF in RyR2R4496C+/- hearts after TAC, confirming our initial hypothesis. In the current project, we aim to identify the mechanism(s) of the transition from hypertrophy to overt HF. We will investigate, whether congenital SR Ca2+ leak in RyR2R4496C+/- cardiomyocytes is increased after TAC and, subsequently, leads to alterations in expression and/or phosphorylation pattern of Ca2+ regulatory proteins and transcription factors involved in Ca2+-dependent hypertrophic signalling pathways. Using in vivo ECG recordings, we will further determine the cause for premature cardiac death in RyR2R4496C+/--TAC mice. Additionally, rescue experiments will reveal, whether a putative RyR2 stabilizer (JTV-519) effectively decelerates the HF progression. \r\nWe anticipate that these results will help to define a new role for SR Ca2+ release in the transition from cardiac hypertrophy to HF. Since abnormal RyR2 Ca2+ release is regarded as the underlying mechanism for contractile dysfunction and arrhythmias, this project may contribute to the identification of novel molecular therapeutic targets in HF and thus, possibly improve clinical outcome in HF patients in the future.\r\n" }, "begin_planned": "2011-01-01T01:00:00+01:00", "begin_effective": "2011-01-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2013-04-02T15:52:03+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 60041, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3226-60041-10" ] }, { "id": 2255, "title": { "de": "Analyse der genetischen Veränderungen in melanozytären Tumoren mit unsicherem maligenen Potential", "en": "Analysis of Genetic Changes in Equivocal Melanocytic Tumours to Improve Diagnosis and Management" }, "short": "EQUIVOCAL MELANOCYTIC TUMOURS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-08-01T02:00:00+02:00", "begin_effective": "2010-08-01T02:00:00+02:00", "end_planned": "2012-07-31T02:00:00+02:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2010-07-16T15:00:22+02:00", "program": 79, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 51751, "contact": 51751, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2255-58889-12", "2255-51751-10" ] }, { "id": 2192, "title": { "de": "Akupressur-Stimulationsequipment zur emotionalen Entlastung von Menschen mit geistiger Behinderung", "en": "Akupressur-Stimulationsequipment zur emotionalen Entlastung von Menschen mit geistiger Behinderung" }, "short": "AKUPRESSUR_STIMULATION", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2010-05-03T14:28:49+02:00", "program": null, "subprogram": null, "organization": 14044, "category": 10, "type": 10, "partner_function": 4, "manager": 51073, "contact": 51073, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2192-51073-10" ] }, { "id": 2750, "title": { "de": "Biostatistisch-genomische Analyse der klinischen Relevanz von Leberkrebsmodellen", "en": "Biostatistical-genomical analysis of the clinical relevance of liver cancer models " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-05-01T02:00:00+02:00", "end_planned": "2013-02-28T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2012-01-18T10:56:20+01:00", "program": null, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 4, "manager": 51684, "contact": 51684, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1019 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2750-51684-10" ] }, { "id": 2482, "title": { "de": "Experience-oriented Sharing of Health Knowledge via Information and Communication Technology", "en": "Experience-oriented Sharing of Health Knowledge via Information and Communication Technology" }, "short": "ESICT", "url": null, "abstract": { "de": "Die ESICT-Konsortium (Experience-oriented Sharing of health knowledge via Information and Communication Technology) wird von dem dänischen Strategic Research Council finanziert. ESICT konzentriert sich auf die wissenschaftliche Untersuchung und Entwicklung von Methoden und Technologien, welche Bürgern mittels eines innovativen Informationssystems über chronische Erkrankungen aufklärt, unter Verwendung von Sprachtechnologien und medizinischen Wissensbasen. Das Ziel von ESICT ist die computergestützte Beantwortung von natürlichsprachigen Benutzeranfragen.", "en": "The ESICT consortium (Experience-oriented Sharing of health knowledge via Information and Communication Technology) is funded by the Danish Strategic Research Council. ESICT focuses on research in methods and development of technologies providing citizens with an innovative information system on chronic diseases based on language technology and formalized medical knowledge. The goal of ESICT is to allow users to ask questions in natural language. " }, "begin_planned": "2010-12-01T01:00:00+01:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2012-11-30T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2011-05-19T18:33:42+02:00", "program": null, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 2, "manager": 72306, "contact": 72306, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2482-72306-10" ] }, { "id": 2435, "title": { "de": "ERASMUS Führungskräfte für Public Health in Europa", "en": "Leaders for European Public Health" }, "short": "LEPHIE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-10-01T02:00:00+02:00", "begin_effective": "2010-10-01T02:00:00+02:00", "end_planned": "2013-03-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2011-03-03T10:21:23+01:00", "program": 93, "subprogram": "ERASMUS Curriculum Development", "organization": 14509, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2783, "title": { "de": "Ein neuartiges System zum Monitoring multipler Neuroparameter zur nicht-invasiven Überwachung in Patienten mit Schlaganfall, Hirnverletzung, nach Herz-Kreislaufstillstand, und Schlaf-Apnoe Syndrom - OPTOBRAIN, Projektnummer: 834110", "en": "A new multi-parameter neuromonitoring system to save patients' lives in stroke, brain injury, cardiac arrest and sleep apnoea" }, "short": "OPTO-BRAIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-11-01T01:00:00+01:00", "begin_effective": "2011-11-01T01:00:00+01:00", "end_planned": "2013-10-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2012-02-14T13:22:05+01:00", "program": null, "subprogram": null, "organization": 14050, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "834110", "ethics_committee": null, "edudract_number": null, "persons": [ "2783-52006-12" ] }, { "id": 2726, "title": { "de": "iCare-Pathway", "en": "iCare-Pathway" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-15T02:00:00+02:00", "begin_effective": "2011-05-15T02:00:00+02:00", "end_planned": "2013-06-30T02:00:00+02:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2012-01-12T12:58:41+01:00", "program": null, "subprogram": null, "organization": 14509, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2802, "title": { "de": "Psychologische und physiologische Stressbelastung bei Patienten mit Aderhautmelanom", "en": "Psychological and physiological stress and stress reactivity in patients with recently diagnosed Uveal Melanoma" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-04-01T02:00:00+02:00", "begin_effective": "2012-04-01T02:00:00+02:00", "end_planned": "2013-09-30T02:00:00+02:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2012-03-02T13:56:54+01:00", "program": 79, "subprogram": null, "organization": 29447, "category": 10, "type": 10, "partner_function": 4, "manager": 51505, "contact": 51505, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2802-61522-12", "2802-65659-12", "2802-51505-10" ] }, { "id": 2626, "title": { "de": "Identifizierung neuer genetischer Ursachen für familiäres Primäres Offenwinkelglaukom (POWG) mittels Komplett-Exom-Sequenzierung", "en": "Identification of novel genes associated with familial Primary Open Angle Glaucoma by use of Whole-Exome-Sequencing" }, "short": "Genetik POWG", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-08-16T02:00:00+02:00", "begin_effective": "2011-08-16T02:00:00+02:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2011-11-07T09:56:07+01:00", "program": null, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4136, "title": { "de": "\"Chordome - Erforschung neuer therapeutischer Targets\"", "en": "“Chordomas – Studying Possible Therapeutic Targets”" }, "short": "Chordom HDAC", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-01-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2015-11-02T09:51:00+01:00", "program": 92, "subprogram": "Marietta Blau-Stipendium", "organization": 14052, "category": 10, "type": 10, "partner_function": 2, "manager": 50448, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4136-50448-10" ] }, { "id": 2920, "title": { "de": "Modellierung der intra-abdominellen Hypertonie", "en": "Modeling Intra-abdominal Hypertension" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-07-01T02:00:00+02:00", "begin_effective": "2012-07-01T02:00:00+02:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2012-07-23T10:14:08+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2871, "title": { "de": "Determinanten und neurobiologische Aspekte von Essstörungen - Gehirnaktivität als Reaktion auf Geschmacksstimuli bei Patientinnen, die an einer Essstörung leiden, im Vergleich zu deren gesunden Müttern und gesunden Kontrollpersonen", "en": "Determinanten und neurobiologische Aspekte bei Essstörungen" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2012-01-01T01:00:00+01:00", "end_planned": "2013-06-30T02:00:00+02:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2012-05-24T10:54:46+02:00", "program": null, "subprogram": null, "organization": 14024, "category": 10, "type": 10, "partner_function": 4, "manager": 51845, "contact": 51845, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2871-51845-10" ] }, { "id": 3159, "title": { "de": "Assoziation von Biomarkern des Knochen- und Nierenstoffwechsels mit der kardiovaskulären Mortalität", "en": "Association of biomarkers of kidney, bone and vitamin D metabolism with cardiovascular mortality " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-01-01T01:00:00+01:00", "end_planned": "2014-01-31T01:00:00+01:00", "end_effective": "2014-01-31T01:00:00+01:00", "assignment": "2013-01-29T09:41:32+01:00", "program": 79, "subprogram": null, "organization": 14028, "category": 10, "type": 10, "partner_function": 4, "manager": 50886, "contact": 50886, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3159-50886-10" ] }, { "id": 2940, "title": { "de": "Ein Vergleich häufig verwendeter Opiate und Hypnotika hinsichtlich ihres Einflusses auf die gastrointestinale Motilität", "en": "a comparison of frequently used opioids and hypnotics regarding their influence on gastrointestinal motility" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-01T02:00:00+02:00", "begin_effective": "2012-04-01T02:00:00+02:00", "end_planned": "2012-04-01T02:00:00+02:00", "end_effective": "2014-01-31T01:00:00+01:00", "assignment": "2012-08-08T15:49:29+02:00", "program": null, "subprogram": null, "organization": 14070, "category": 10, "type": 10, "partner_function": 4, "manager": 71082, "contact": 71082, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2940-71082-10" ] }, { "id": 2154, "title": { "de": "Contribution of cell-cell contacts and cross-talk to cell conversion into cardiomyocytes ", "en": "Contribution of cell-cell contacts and cross-talk to cell conversion into cardiomyocytes " }, "short": "CARDIOMYOCYTES", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2011-02-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-01-31T01:00:00+01:00", "assignment": "2010-03-04T15:03:51+01:00", "program": 72, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P22466", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2155, "title": { "de": "Remote Assessibility to Diabetes Management and Therapy in Operational healthcare Networks - REACTION", "en": "Remote Assessibility to Diabetes Management and Therapy in Operational healthcare Networks - REACTION" }, "short": "REACTION", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-03-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-02-28T01:00:00+01:00", "assignment": "2010-03-05T10:04:48+01:00", "program": 24, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "248590", "ethics_committee": null, "edudract_number": null, "persons": [ "2155-51831-10", "2155-59231-12", "2155-64875-12", "2155-65558-12" ] } ] }