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GET /v1/research/project/?format=api&offset=520&ordering=end_effective
{ "count": 2245, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=540&ordering=end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=500&ordering=end_effective", "results": [ { "id": 2877, "title": { "de": "Disseminierende Tumorzellen bei primär metastasierten Brustkrebspatientinnen mit Chirurgie des Primärtumors", "en": "Disseminating tumor cells in primary metastasized breast cancer patients undergoing surgery of primary tumor" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-06-11T02:00:00+02:00", "begin_effective": "2012-06-11T02:00:00+02:00", "end_planned": "2013-06-09T02:00:00+02:00", "end_effective": "2013-06-30T02:00:00+02:00", "assignment": "2012-06-05T16:53:54+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 80692, "contact": 80692, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 122 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2877-80692-10" ] }, { "id": 2633, "title": { "de": "Interface Mundraum: Analyse und in vitro Simulation oraler Bakteriengemeinschaften auf natürlichen und künstlichen Materialien", "en": "Interface oral cavity: analyses and in vitro simulation of oral bacterial communities on natural and artificial surfaces" }, "short": "OraSim", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-11-01T01:00:00+01:00", "begin_effective": "2011-11-01T01:00:00+01:00", "end_planned": "2013-02-28T01:00:00+01:00", "end_effective": "2013-06-30T02:00:00+02:00", "assignment": "2011-11-09T15:28:14+01:00", "program": null, "subprogram": "Human Technology Interface", "organization": 14109, "category": 10, "type": 10, "partner_function": 4, "manager": 50051, "contact": 50051, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2633-50051-10" ] }, { "id": 2893, "title": { "de": "Ischemic Stroke Genome Wide Association Study (IS-GWAS)", "en": "Ischemic Stroke Genome Wide Association Study (IS-GWAS)" }, "short": "IS-GWAS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-01T02:00:00+02:00", "begin_effective": "2012-04-01T02:00:00+02:00", "end_planned": "2013-03-31T01:00:00+01:00", "end_effective": "2013-06-30T02:00:00+02:00", "assignment": "2012-06-19T15:08:13+02:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2682, "title": { "de": "Nachhaltige Grazer biomedizintechnische TCM-Forschung zur Prävention chronischer Erkrankungen", "en": "Sustainable biomedical engineering TCM-research in Graz for prevention of chronic diseases" }, "short": "Grazer Biomed TCM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-01T02:00:00+02:00", "begin_effective": "2011-12-01T01:00:00+01:00", "end_planned": "2013-02-28T01:00:00+01:00", "end_effective": "2013-06-30T02:00:00+02:00", "assignment": "2011-12-13T11:32:16+01:00", "program": null, "subprogram": null, "organization": 14044, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1903, "title": { "de": "Funktionelle Magentresonanztomographie zum Studium motorischer Rehabilitation nach Schlaganfall", "en": "Funktionelle Magentresonanztomographie zum Studium motorischer Rehabilitation nach Schlaganfall" }, "short": "Motorische Rehabilitation ", "url": null, "abstract": { "de": "Die funktionelle Limitation motorischer Defizite nach Schlafganfall steht im Zentrum der Bemühungen der Neurorehabilitation. Moderne neurorehabilitative Strategien zielen hierbei primär auf eine Förderung neuronaler Plastizität ab, wobei das individuelle Ansprechen auf therapeutische Bemühungen auf Basis klinischer Kriterien schwer vorhersagbar ist. Im vorliegenden Projekt soll die Methode der funktionellen Magnetresonanztomographie (fMRT) eingesetzt werden, um zu klären, inwieweit Unterschiede in mit motorischem Sequenzlernen assoziierten fMRT Aktivierungsänderungen Vorhersagewert im Hinblick auf die motorische Rehabilitationsfähigkeit von Schlaganfall-Betroffenen aufweisen. Von derartigen Einblicken lassen sich unter Umständen eine wesentliche Hilfestellung hinsichtlich der Selektion von PatientInnen oder auch die Entwicklung neuartiger Rehabilitationsstrategien erhoffen.", "en": "Die funktionelle Limitation motorischer Defizite nach Schlafganfall steht im Zentrum der Bemühungen der Neurorehabilitation. Moderne neurorehabilitative Strategien zielen hierbei primär auf eine Förderung neuronaler Plastizität ab, wobei das individuelle Ansprechen auf therapeutische Bemühungen auf Basis klinischer Kriterien schwer vorhersagbar ist. Im vorliegenden Projekt soll die Methode der funktionellen Magnetresonanztomographie (fMRT) eingesetzt werden, um zu klären, inwieweit Unterschiede in mit motorischem Sequenzlernen assoziierten fMRT Aktivierungsänderungen Vorhersagewert im Hinblick auf die motorische Rehabilitationsfähigkeit von Schlaganfall-Betroffenen aufweisen. Von derartigen Einblicken lassen sich unter Umständen eine wesentliche Hilfestellung hinsichtlich der Selektion von PatientInnen oder auch die Entwicklung neuartiger Rehabilitationsstrategien erhoffen." }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2013-07-01T02:00:00+02:00", "end_effective": "2013-07-01T02:00:00+02:00", "assignment": "2009-08-27T14:08:42+02:00", "program": 79, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 50173, "contact": 50173, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1903-70680-12", "1903-50173-10" ] }, { "id": 2860, "title": { "de": "Arterial Stiffness, Stress Coping and Health Locus of Control", "en": "Arterial Stiffness, Stress Coping and Health Locus of Control" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-05-01T02:00:00+02:00", "begin_effective": "2012-05-01T02:00:00+02:00", "end_planned": "2013-07-30T02:00:00+02:00", "end_effective": "2013-07-30T02:00:00+02:00", "assignment": "2012-05-16T10:57:28+02:00", "program": null, "subprogram": null, "organization": 29447, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3285, "title": { "de": "Endoskopische, bildverarbeitungsgestützte Diagnostik frühmagnialer Veräderungen bei Barretts-Ösophagus", "en": "Endoskopische, bildverarbeitungsgestützte Diagnostik frühmagnialer Veräderungen bei Barretts-Ösophagus" }, "short": "EBIDAVROS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-08-01T02:00:00+02:00", "begin_effective": "2011-08-01T02:00:00+02:00", "end_planned": "2012-08-31T02:00:00+02:00", "end_effective": "2013-07-30T02:00:00+02:00", "assignment": "2013-05-23T11:43:59+02:00", "program": null, "subprogram": "HTI", "organization": 14081, "category": 10, "type": 10, "partner_function": 2, "manager": 51539, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3285-51539-10" ] }, { "id": 3016, "title": { "de": "Reduzierter Opioidverbrauch durch Physostigmin als Dauertropf zur postoperativen PCA - PHANOS (PHysostigmine-enHAnced Opioid analgeSia) Folgestudie", "en": "PHANOS - PHysostigmine-enHAnced Opioid analgeSia" }, "short": "PHANOS", "url": null, "abstract": { "de": "Zahlreiche Studien haben gezeigt, dass cholinerge Mechanismen eine zentrale Rolle im antinozizeptiven System spielen, indem sie synergistisch mit Morphin wirken und den postoperativen Opioidverbrauch reduzieren. Darüber hinaus hat das Anti-Cholinesterase-Medikament Physostigmin, das die synaptische Acetylcholin-Konzentration erhöht, entzündungshemmende Wirkungen. In dieser randomisierten, placebokontrollierten Studie mit 110 Patienten, die sich einer Nephrektomie unterzogen, untersuchten wir die Auswirkungen einer intraoperativen Physostigmin-Infusion von 0,5 mg h-1 i.v. über 24 Stunden auf den Opioidverbrauch, die Hyperalgesie, die Schmerzwerte und die Zufriedenheit mit der Schmerzkontrolle. \r\n\r\nÜbersetzt mit www.DeepL.com/Translator (kostenlose Version)", "en": "Several studies have shown that cholinergic mechanisms play a pivotal role in the anti-nociceptive system by acting synergistically with morphine and reducing postoperative opioid consumption. In addition, the anti-cholinesterase drug physostigmine that increases synaptic acetylcholine concentrations has anti-inflammatory effects. In this randomised placebo-controlled trial including 110 patients undergoing nephrectomy, we evaluated the effects of intraoperative physostigmine 0.5 mg h-1 i.v. for 24 h on opioid consumption, hyperalgesia, pain scores, and satisfaction with pain control. " }, "begin_planned": "2012-07-01T02:00:00+02:00", "begin_effective": "2012-11-01T01:00:00+01:00", "end_planned": "2014-12-31T01:00:00+01:00", "end_effective": "2013-07-30T02:00:00+02:00", "assignment": "2012-10-25T16:06:20+02:00", "program": null, "subprogram": "Land Steiermark unter 5.000,-", "organization": 14069, "category": 10, "type": 10, "partner_function": 4, "manager": 58422, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3016-58422-10", "3016-51915-12" ] }, { "id": 2548, "title": { "de": "Ko-Kultursystem für die frühe Plazentation mit unterschiedlichen Sauerstoffkonzentrationen", "en": "Co-Culture System for early placentation with different oxygen-concentrations" }, "short": "CO-CULTURE SYSTEM EARLY PLACENTATION", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-03-01T01:00:00+01:00", "begin_effective": "2011-08-01T02:00:00+02:00", "end_planned": "2012-02-28T01:00:00+01:00", "end_effective": "2013-07-30T02:00:00+02:00", "assignment": "2011-07-28T15:36:26+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 58943, "contact": 58943, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2548-58943-10" ] }, { "id": 3014, "title": { "de": "Der Schmerz und seine Begleitaspekte - Evaluation des postoperative Schmerzerlebens bei Kindern und Jugendlichen", "en": "Evaluation of the postoperative painexperience in children and adolescent" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-07-01T02:00:00+02:00", "begin_effective": "2012-10-01T02:00:00+02:00", "end_planned": "2012-10-31T01:00:00+01:00", "end_effective": "2013-07-30T02:00:00+02:00", "assignment": "2012-10-25T10:02:24+02:00", "program": null, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 4, "manager": 67207, "contact": 67207, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3014-67207-10" ] }, { "id": 2119, "title": { "de": "Alzheimer drugs incorporated in nanoparticles for specific transport over the blood brain barrier (NanoBrain)", "en": "Alzheimer drugs incorporated in nanoparticles for specific transport over the blood brain barrier (NanoBrain)" }, "short": "NanoBrain", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-10-01T02:00:00+02:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2010-02-12T14:34:51+01:00", "program": 64, "subprogram": "ERA-Net", "organization": 14051, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I453", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2526, "title": { "de": "Rezeptoren und Metabolite von Prostaglandinen im Morbus Crohn und der ulzerösen Kolitis", "en": "DP receptors and their prostaglandin metabolite ligands: a good or bad match for human IBD?" }, "short": "DP receptors in IBD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-08-01T02:00:00+02:00", "begin_effective": "2011-08-01T02:00:00+02:00", "end_planned": "2013-07-31T02:00:00+02:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2011-07-12T16:34:21+02:00", "program": 79, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 56687, "contact": 56687, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2526-56687-10" ] }, { "id": 2431, "title": { "de": "Genetic predisposition to therapy-related myeloid neoplasms: involvement of the Fanconi anemia/BRCA pathway?", "en": "Genetic predisposition to therapy-related myeloid neoplasms: involvement of the Fanconi anemia/BRCA pathway?" }, "short": "FANCONI ANEMIA BRCA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2011-02-28T11:28:49+01:00", "program": 79, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51857, "contact": 51857, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2431-77371-12", "2431-77615-12", "2431-51857-10", "2431-50116-12" ] }, { "id": 3018, "title": { "de": "Automatisierte Erkennung eines Herzgeräusches (Systolikums) mittels Phonokardiographie", "en": "Automated analysis of cardial murmurs with phonocardiography" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-08-01T02:00:00+02:00", "begin_effective": "2012-08-01T02:00:00+02:00", "end_planned": "2013-07-31T02:00:00+02:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2012-10-31T11:54:12+01:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 50907, "contact": 50907, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3018-50907-10" ] }, { "id": 1777, "title": { "de": "The role of C/EBPa on the development of monocyte subsets", "en": "The role of C/EBPa on the development of monocyte subsets" }, "short": "C/EBPa", "url": null, "abstract": { "de": "The integrity of the hematopoietic system depends on a large number of blood cell lineages being continuously replenished from a rare population of pluripotent heatopoietic stem cells(HSC), representing a paradigm for how multilineage diversity can be achieved from a common stem cell through lineage commitment and subsequent differentiation.\r\nMonocytes are mononuclear cells and represent about 10% of leukocytes in human blood and 4% of leukocytes in mouse blood. The best known function of monocytes is their role as accessory cells, which link inflammation and the innate defense system against microorganisms to adaptive immune response.\r\nMany factors are involved in monocyte differentiation like PU.1, IRF8, KLF-4, MafB, c-maf and C/EBPalpha. C/EBPalpha (CCAAT/enhancer binding protein alpha) is a basic region-leucine zipper transcription factor and indispensable for formation of mature neutrophils and eosinophils. It is expressed at low levels in HSC, and is up-regulated to its highest levels in GMP(granulocyte/monocyte progenitors), whereas it is not expressed in precursors of lymphoid cells and is downregulated as CMP differentiate to MEP(megakaryocyte/erythrocyte progenitors). Mice-studies indicate that C/EBPalpha is essential for transition of CMP to GMP.\r\n\r\nWe hypothesize that C/EBPalpha positive and C/EBPalpha negative monocytes represent distinct subgroups of monocytes, which also differ in their function. In addition, we speculate that they are derived from different progenitors. To experimentally approach this hypothesis we want to use the C/EBPalphaCRE EYFP reporter mouse model.", "en": "The integrity of the hematopoietic system depends on a large number of blood cell lineages being continuously replenished from a rare population of pluripotent heatopoietic stem cells(HSC), representing a paradigm for how multilineage diversity can be achieved from a common stem cell through lineage commitment and subsequent differentiation.\r\nMonocytes are mononuclear cells and represent about 10% of leukocytes in human blood and 4% of leukocytes in mouse blood. The best known function of monocytes is their role as accessory cells, which link inflammation and the innate defense system against microorganisms to adaptive immune response.\r\nMany factors are involved in monocyte differentiation like PU.1, IRF8, KLF-4, MafB, c-maf and C/EBPalpha. C/EBPalpha (CCAAT/enhancer binding protein alpha) is a basic region-leucine zipper transcription factor and indispensable for formation of mature neutrophils and eosinophils. It is expressed at low levels in HSC, and is up-regulated to its highest levels in GMP(granulocyte/monocyte progenitors), whereas it is not expressed in precursors of lymphoid cells and is downregulated as CMP differentiate to MEP(megakaryocyte/erythrocyte progenitors). Mice-studies indicate that C/EBPalpha is essential for transition of CMP to GMP.\r\n\r\nWe hypothesize that C/EBPalpha positive and C/EBPalpha negative monocytes represent distinct subgroups of monocytes, which also differ in their function. In addition, we speculate that they are derived from different progenitors. To experimentally approach this hypothesis we want to use the C/EBPalphaCRE EYFP reporter mouse model." }, "begin_planned": "2009-05-01T02:00:00+02:00", "begin_effective": "2009-08-01T02:00:00+02:00", "end_planned": "2010-04-30T02:00:00+02:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2009-04-07T10:52:48+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51911, "contact": 51911, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1777-58889-12", "1777-51911-10" ] }, { "id": 3053, "title": { "de": "Genetische Charakterisierung einer steirischen Familie mit einem familiären kolorektalen Syndrom X", "en": "Genetic characterization of a Styrian family with colorectal cancer type X" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-11-01T01:00:00+01:00", "begin_effective": "2012-11-01T01:00:00+01:00", "end_planned": "2013-11-01T01:00:00+01:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2012-11-27T13:32:52+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 77615, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3053-77615-10" ] }, { "id": 2904, "title": { "de": "Prognostische und therapeutische Relevanz von steatohepatitischen Veränderungen beim Hepatozellulären Karzinom", "en": "Prognostic and therapeutic relevance of steatohepatitic features in hepatocellular carinoma" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-08-01T02:00:00+02:00", "begin_effective": "2012-08-01T02:00:00+02:00", "end_planned": "2013-08-01T02:00:00+02:00", "end_effective": "2013-08-31T02:00:00+02:00", "assignment": "2012-06-27T13:08:00+02:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 50871, "contact": 50871, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2904-50871-10" ] }, { "id": 1878, "title": { "de": "Anandamide/LPI signaling & function in endothelial cells", "en": "Anandamide/LPI signaling & function in endothelial cells" }, "short": "Anandamide/LPI", "url": null, "abstract": { "de": "Anandamide (ANA), also known as N-arachidonoylethanolamine, is a prominent substance of endocannabinoids, and exhibits multiple physiological functions in the brain, the immune system and the cardiovasculature. Although ANA is well known to contribute to human behavior, like eating and sleeping, and pain relief, evidence accumulated that ANA is an important vascular mediator that is released during tissue stress. LPI (lysophosphatidylinositol is another putatively important lipid mediator in the vessel wall.\r\nThe overall aim of this project is to explore ANA/LPI as important vascular mediators, to characterize their respective signal transduction, their interrelation and consequences to endothelial cell functions. In the end, our proposal aims to provide the scientific basis of consideration of the ANA/LPI system as therapeutic target for vascular-related medicine.", "en": "Anandamide (ANA), also known as N-arachidonoylethanolamine, is a prominent substance of endocannabinoids, and exhibits multiple physiological functions in the brain, the immune system and the cardiovasculature. Although ANA is well known to contribute to human behavior, like eating and sleeping, and pain relief, evidence accumulated that ANA is an important vascular mediator that is released during tissue stress. LPI (lysophosphatidylinositol is another putatively important lipid mediator in the vessel wall.\r\nThe overall aim of this project is to explore ANA/LPI as important vascular mediators, to characterize their respective signal transduction, their interrelation and consequences to endothelial cell functions. In the end, our proposal aims to provide the scientific basis of consideration of the ANA/LPI system as therapeutic target for vascular-related medicine." }, "begin_planned": "2009-07-01T02:00:00+02:00", "begin_effective": "2009-10-01T02:00:00+02:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2009-07-30T13:21:16+02:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51860, "contact": 51860, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P21857", "ethics_committee": null, "edudract_number": null, "persons": [ "1878-50810-11", "1878-51860-10" ] }, { "id": 1640, "title": { "de": "Effect of ivabradine, a novel If-blocker, on human atrial myocytes under elevated endotoxin levels", "en": "Effect of ivabradine, a novel If-blocker, on human atrial myocytes under elevated endotoxin levels" }, "short": "IVABRADINE_FWF08", "url": null, "abstract": { "de": "Endotoxine (Lipopolysaccharide, LPSe), die Auslöser von gram-negativer Sepsis, führen durch Interaktion mit den Wirtszellen zu einer Vielzahl von biologischen Reaktionen. Kürzlich konnten wir in einer Publikation zeigen, dass LPS den Schrittmacherstrom If in humanen Vorhofzellen, nach 6-stündiger Inkubation hemmt, ein Ereignis, das für das Verständnis der bei Sepsis auftretenden Reduktion der Herzfrequenzvariabilität von großer Relevanz ist.\r\nAusgehend von der hemmenden LPS-Wirkung auf If sollen 2 große Themenschwerpunkte untersucht werden:\r\n*Interaktion von Ivabradine und Endotoxin auf den humanen If\r\n*Mechanismus der Endotoxinwirkung", "en": "Endotoxine (Lipopolysaccharide, LPSe), die Auslöser von gram-negativer Sepsis, führen durch Interaktion mit den Wirtszellen zu einer Vielzahl von biologischen Reaktionen. Kürzlich konnten wir in einer Publikation zeigen, dass LPS den Schrittmacherstrom If in humanen Vorhofzellen, nach 6-stündiger Inkubation hemmt, ein Ereignis, das für das Verständnis der bei Sepsis auftretenden Reduktion der Herzfrequenzvariabilität von großer Relevanz ist.\r\nAusgehend von der hemmenden LPS-Wirkung auf If sollen 2 große Themenschwerpunkte untersucht werden:\r\n*Interaktion von Ivabradine und Endotoxin auf den humanen If\r\n*Mechanismus der Endotoxinwirkung" }, "begin_planned": "2008-10-01T02:00:00+02:00", "begin_effective": "2009-10-01T02:00:00+02:00", "end_planned": "2011-09-30T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2008-10-13T14:02:42+02:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 50615, "contact": 50615, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P21159", "ethics_committee": null, "edudract_number": null, "persons": [ "1640-50615-10", "1640-50417-12", "1640-50969-12", "1640-51592-12" ] }, { "id": 2906, "title": { "de": "Der Einfluss der Proteinkinase D2 auf den Glukosemetabolismus von Glioblastomzellen.", "en": "Protein Kinase D2 and its influence on the glucose metabolism of glioblastoma cells." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-07-01T02:00:00+02:00", "end_planned": "2012-05-31T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2012-06-28T10:34:12+02:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 50990, "contact": 50990, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2906-50990-10" ] } ] }