Project List
List projects.
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GET /v1/research/project/?format=api&offset=500&ordering=end_planned
{ "count": 2261, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=520&ordering=end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=480&ordering=end_planned", "results": [ { "id": 3100, "title": { "de": "Qualitätsmanagement der präklinischen Reanimation mittels Postevent Performance Debriefing", "en": "Quality management in prehospital cardio-pulmonary resuscitation with postevent performance debriefing" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-06-01T02:00:00+02:00", "begin_effective": "2012-12-15T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-12-30T01:00:00+01:00", "assignment": "2012-12-10T11:18:18+01:00", "program": null, "subprogram": "Land Steiermark unter 5.000,- Euro", "organization": 14070, "category": 10, "type": 10, "partner_function": 4, "manager": 67711, "contact": 67711, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3100-67711-10" ] }, { "id": 2146, "title": { "de": "AP@home", "en": "AP@home" }, "short": "AP@home", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-10-01T02:00:00+02:00", "begin_effective": "2010-02-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-10-31T01:00:00+01:00", "assignment": "2010-03-02T11:22:16+01:00", "program": 24, "subprogram": "ICT: FP7-ICT-2009-4", "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": 51831, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2146-51831-10", "2146-50877-12", "2146-61759-12", "2146-56674-12", "2146-50731-12" ] }, { "id": 2642, "title": { "de": "Netzwerk für Semantische Interoperabilität im Gesundheitswesen", "en": "Semantic Interoperability for Health Network" }, "short": "SemanticHealthNet", "url": "http://www.semantichealthnet.eu/", "abstract": { "de": "SemanticHealthNet entwickelt eine europäische Organisations-und Governance-Struktur für die semantische Interoperabilität von klinischen Daten und Wissen, um computergestützte Informationssysteme für die Patientenversorgung, der öffentlichen Gesundheit und der klinischen Forschung über Systeme und Institutionen zu optimieren. \r\nSemanticHealthNet wird Erfordernisse für evidenzbasierte, patientenorientierte integrierte Versorgung und für die öffentliche Gesundheitspflege erheben, wobei auf bestehenden europäischen Konsens in der Behandlung der chronischen Herzinsuffizienz und für Herz-Kreislauf-Prävention aufgebaut wird. Experten für elektronische Patientenakten, klinische Datenstrukturen, Terminologien und Ontologien werden ihre methodischen Ansätze optimieren, um den Austausch klinischer Daten zu verbessern. Gesundheitsbehörden und klinische Experten, Ministerien, Softwarehersteller, und Versicherungen sind über klinische und Industriebeiräte eingebunden, um so sicherzustellen, dass die Ergebnisse realistisch und nachhaltig umsetzbar sind. Ein Geschäftsmodell wird entwickelt, das strategische Investitionen, einschließlich der Kosten für wichtige Stakeholder wie Standardisierungsorganisationen und Industrie rechtfertigt. Angestrebt wird die Etablierung des Netzwerks als virtuelle Organisation, die die Förderung von Entwicklungen zur Erreichung semantische Interoperabilität aufrechterhält. Das Konsortium bindet auch mehr als 40 international anerkannten Experten, darunter aus den USA und Kanada, und hat somit auch eine über Europa hinausreichende Dimension. ", "en": "SemanticHealthNet will develop a European organisational and governance process for the semantic interoperability of clinical data and knowledge, to help ensure that health record systems are optimised for patient care, public health and clinical research across systems and institutions. SemanticHealthNet will capture the needs for evidence-based, patient-centred integrated care and for public health, encapsulating existing European consensus in the management of chronic heart failure and cardiovascular prevention. Experts in EHR architectures, clinical data structures, terminologies and ontologies will combine, tailor and pilot their best-of-breed resources in response to optimise clinical data and information exchange. Health authorities, clinical professionals, ministries, vendors, purchasers, insurers are involved via Clinical and Industrial Advisory Boards to ensure that the project approach and results are realistically adoptable and sustainable. A business model to justify strategic investments, including the opportunity costs for key stakeholders such as SDOs, industry, will be defined. This, and links with epSOS II and the eHealth Governance Initiative, will inform the shape of the Virtual Organisation that this Network will establish to sustain semantic interoperability developments and their adoption. The consortium includes more than 40 internationally recognised experts, including from the U.S. and Canada, ensuring a global impact.\r\n" }, "begin_planned": "2012-01-01T01:00:00+01:00", "begin_effective": "2011-12-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2015-05-31T02:00:00+02:00", "assignment": "2011-11-18T13:48:18+01:00", "program": 24, "subprogram": "FP7-ICT-2011-7", "organization": 14026, "category": 10, "type": 10, "partner_function": 2, "manager": 72306, "contact": 72306, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "285609", "ethics_committee": null, "edudract_number": null, "persons": [ "2642-72306-10" ] }, { "id": 3217, "title": { "de": "Die krebshemmende Wirkung von Cucurbitacin F Verbindungen auf humane Weichteilsarkome", "en": "Inhibitory Effect of Cucurbitacin F Compounds on Chemotherapy Resistant Human Soft Tissue Sarcoma" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-01-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-09-30T02:00:00+02:00", "assignment": "2013-03-20T09:58:07+01:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50696, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3217-50696-10" ] }, { "id": 3040, "title": { "de": "Intestinale Kolonisation mit Extended-spectrum beta-lactamase-bildenden Enterobakterien als möglicher Risikofaktor für die Entwicklung einer neonatalen Nekrotisierenden Enterocolitis (NEC)", "en": "Intestinal Colonisation with Extended-spectrum beta-lactamase-producing Enterobacteriaceae as a possible risk factor for the development of neonatal necrotising enterocolitis (NEC)" }, "short": "ESBL und NEC", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-10-01T02:00:00+02:00", "begin_effective": "2012-10-01T02:00:00+02:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-09-30T02:00:00+02:00", "assignment": "2012-11-13T14:40:30+01:00", "program": null, "subprogram": "Land Steiermark < 5.000,- Euro", "organization": 14092, "category": 10, "type": 10, "partner_function": 4, "manager": 56810, "contact": 56810, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3040-56810-10" ] }, { "id": 2119, "title": { "de": "Alzheimer drugs incorporated in nanoparticles for specific transport over the blood brain barrier (NanoBrain)", "en": "Alzheimer drugs incorporated in nanoparticles for specific transport over the blood brain barrier (NanoBrain)" }, "short": "NanoBrain", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-10-01T02:00:00+02:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2010-02-12T14:34:51+01:00", "program": 64, "subprogram": "ERA-Net", "organization": 14051, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I453", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2293, "title": { "de": "Die pulmonale Mikrozirkulation bei Sepsis und Adipositas", "en": "Pulmonary Microcirculation during Sepsis and Obesity The Role of Cytokines and Adhesion Molecules" }, "short": "PULMONALE MIKROZIRK SEPSIS ADIPOS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-01-01T01:00:00+01:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2015-10-31T01:00:00+01:00", "assignment": "2010-09-07T13:56:50+02:00", "program": 72, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 50778, "contact": 50778, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P22567", "ethics_committee": null, "edudract_number": null, "persons": [ "2293-50778-10" ] }, { "id": 2154, "title": { "de": "Contribution of cell-cell contacts and cross-talk to cell conversion into cardiomyocytes ", "en": "Contribution of cell-cell contacts and cross-talk to cell conversion into cardiomyocytes " }, "short": "CARDIOMYOCYTES", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2011-02-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-01-31T01:00:00+01:00", "assignment": "2010-03-04T15:03:51+01:00", "program": 72, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P22466", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2450, "title": { "de": "Expression von SUMO-Proteinen bei Tumoren des zentralen Nervensystems", "en": "Expression von SUMO-Proteinen bei Tumoren des zentralen Nervensystems" }, "short": "SUMOylierung bei ZNS-Tumoren", "url": null, "abstract": { "de": "Die Funktion zahlreicher Proteine wird durch einen, SUMOylierung genannten Prozess, eine reversible Bindung von SUMO-Proteinen an Zielsubstrate, modifiziert. Der Einfluss der SUMOylierung auf die Entstehung und das Wachstum von Tumoren ist bislang erst ansatzweise untersucht worden. In diesem mehrstufigen Forschungsprojekt soll die Expression von SUMO-Proteinen in Hirntumorzelllinien und am Tumorfrischmaterial von Tumoren des zentralen Nervensystems untersucht werden. Es soll darüber hinaus überprüft werden, wie sich die Expression von SUMO-Proteinen in Gegenwart zytostatischer (zellwachstumshemmender) Medikamente verändert. Das Projekt soll zum besseren Verständnis der Bedeutung von molekularbiologischen Veränderungen bei Hirntumoren führen. Daraus können sich weitere Hinweise auf Resistenzmechanismen von Tumorzellen gegenüber zytostatischen Einflüssen ergeben.", "en": null }, "begin_planned": "2011-01-01T01:00:00+01:00", "begin_effective": "2011-04-01T02:00:00+02:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-03-31T02:00:00+02:00", "assignment": "2011-03-22T15:09:48+01:00", "program": null, "subprogram": null, "organization": 14092, "category": 10, "type": 10, "partner_function": 4, "manager": 51369, "contact": 51369, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1550 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2450-51369-10" ] }, { "id": 3047, "title": { "de": "Bild- und Tiefeninformation zur automatischen Lagekorrektur von Patienten in medizinischen Geräten", "en": "Bild- und Tiefeninformation zur automatischen Lagekorrektur von Patienten in medizinischen Geräten" }, "short": "BTAL", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-05-01T02:00:00+02:00", "begin_effective": "2012-05-01T02:00:00+02:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-06-30T02:00:00+02:00", "assignment": "2012-11-21T14:39:21+01:00", "program": null, "subprogram": "HTI-Call 2012", "organization": 14043, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2771, "title": { "de": "Cholesterin-25-Hydroxylase beim Glioblastomwachstum", "en": "25-Hydroxycholesterol as transcriptional regulator of the human astrocytoma grade IV (glioblastoma multiforme) tumor microenvironment" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-01-01T01:00:00+01:00", "begin_effective": "2012-01-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2012-02-01T15:45:19+01:00", "program": 79, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 1, "manager": 51705, "contact": 51705, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2771-51705-10" ] }, { "id": 3133, "title": { "de": "Graz Studie an Gesundheit und Altern", "en": "Graz Study on Health and Aging" }, "short": "GSHA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-12-01T01:00:00+01:00", "begin_effective": "2013-03-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2015-03-31T02:00:00+02:00", "assignment": "2013-01-14T14:45:13+01:00", "program": null, "subprogram": "Subventionsansuchen Stadt Graz", "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51912, "contact": 51912, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3133-51912-10" ] }, { "id": 2626, "title": { "de": "Identifizierung neuer genetischer Ursachen für familiäres Primäres Offenwinkelglaukom (POWG) mittels Komplett-Exom-Sequenzierung", "en": "Identification of novel genes associated with familial Primary Open Angle Glaucoma by use of Whole-Exome-Sequencing" }, "short": "Genetik POWG", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-08-16T02:00:00+02:00", "begin_effective": "2011-08-16T02:00:00+02:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2011-11-07T09:56:07+01:00", "program": null, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2155, "title": { "de": "Remote Assessibility to Diabetes Management and Therapy in Operational healthcare Networks - REACTION", "en": "Remote Assessibility to Diabetes Management and Therapy in Operational healthcare Networks - REACTION" }, "short": "REACTION", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-03-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-02-28T01:00:00+01:00", "assignment": "2010-03-05T10:04:48+01:00", "program": 24, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "248590", "ethics_committee": null, "edudract_number": null, "persons": [ "2155-51831-10", "2155-59231-12", "2155-64875-12", "2155-65558-12" ] }, { "id": 3226, "title": { "de": "Von Hypertrophie zur Herzinsuffizienz-die Rolle des spontanen SR Ca2+ Lecks", "en": "From hypertrophy to heart failure-the role of spontaneous SR Ca2+ leak" }, "short": "MUG Start", "url": null, "abstract": { "de": null, "en": "Heart failure (HF) is a leading cause of death in the developed countries. Despite considerable progress in the past decade in our understanding of cellular and molecular mechanisms involved in the progression of HF, therapeutic agents that specifically target the underlying cellular defects remain rare and ineffective. In HF, intracellular Ca2+ homeostasis is altered and increased cytosolic Ca2+ has been proposed as a potential activator of hypertrophic signalling cascades, ultimately culminating in overt HF phenotype. Recent studies pointed out that increased spontaneous Ca2+ release (Ca2+ leak) from the sarcoplasmic reticulum (SR) Ca2+ release channel (ryanodine receptor, RyR2) due to defective regulation of the RyR2 occurs during HF and causes contractile dysfunction and development of arrhythmias. However, it remains controversial whether increased SR Ca2+ leak is an epiphenomenon accompanying HF only or a pathophysiologically relevant process contributing to accelerated decompensation from hypertrophy to HF.\r\nIn the proposed project, we will pursue the hypothesis, that an increased spontaneous SR Ca2+ leak per se is causally involved in accelerated decompensation from cardiac hypertrophy to HF. We will take advantage of the minimally invasive transverse aortic constriction (TAC) as a pressure overload model for HF, and apply it to a mouse model with an inherited SR Ca2+ leak (knock-in RyR2R4496C+/- human mutation). Our preliminary results show strikingly increased hypertrophy and accelerated transition from hypertrophy to HF in RyR2R4496C+/- hearts after TAC, confirming our initial hypothesis. In the current project, we aim to identify the mechanism(s) of the transition from hypertrophy to overt HF. We will investigate, whether congenital SR Ca2+ leak in RyR2R4496C+/- cardiomyocytes is increased after TAC and, subsequently, leads to alterations in expression and/or phosphorylation pattern of Ca2+ regulatory proteins and transcription factors involved in Ca2+-dependent hypertrophic signalling pathways. Using in vivo ECG recordings, we will further determine the cause for premature cardiac death in RyR2R4496C+/--TAC mice. Additionally, rescue experiments will reveal, whether a putative RyR2 stabilizer (JTV-519) effectively decelerates the HF progression. \r\nWe anticipate that these results will help to define a new role for SR Ca2+ release in the transition from cardiac hypertrophy to HF. Since abnormal RyR2 Ca2+ release is regarded as the underlying mechanism for contractile dysfunction and arrhythmias, this project may contribute to the identification of novel molecular therapeutic targets in HF and thus, possibly improve clinical outcome in HF patients in the future.\r\n" }, "begin_planned": "2011-01-01T01:00:00+01:00", "begin_effective": "2011-01-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2013-04-02T15:52:03+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 60041, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3226-60041-10" ] }, { "id": 2525, "title": { "de": "Genetische Typisierung von Klebsiella oxytoca Stämmen in Bezug auf deren Fähigkeit zur Toxinproduktion und Assoziation zur Entstehung von Colitis.", "en": "Typing of Klebsiella oxytoca Strains Concerning to their Ability for Toxin-Production and their Association to the Develoment of Colitis." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2014-01-01T01:00:00+01:00", "end_effective": "2014-10-31T01:00:00+01:00", "assignment": "2011-07-12T16:25:15+02:00", "program": 79, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 53167, "contact": 53167, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2525-53167-10" ] }, { "id": 3197, "title": { "de": "Antibiotika-assoziierte hämorrhagische Kolitis ausgelöst durch Klebsiella oxytoca bei Kindern", "en": "Antibiotic-associated hemorrhagic colitis (AAHC) caused by Klebsiella oxytoca in children and adolescents" }, "short": "AAHC bei Kindern", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-01-01T01:00:00+01:00", "end_planned": "2014-01-01T01:00:00+01:00", "end_effective": "2016-02-28T01:00:00+01:00", "assignment": "2013-03-01T09:57:45+01:00", "program": null, "subprogram": null, "organization": 14091, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 550 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3159, "title": { "de": "Assoziation von Biomarkern des Knochen- und Nierenstoffwechsels mit der kardiovaskulären Mortalität", "en": "Association of biomarkers of kidney, bone and vitamin D metabolism with cardiovascular mortality " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-01-01T01:00:00+01:00", "end_planned": "2014-01-31T01:00:00+01:00", "end_effective": "2014-01-31T01:00:00+01:00", "assignment": "2013-01-29T09:41:32+01:00", "program": 79, "subprogram": null, "organization": 14028, "category": 10, "type": 10, "partner_function": 4, "manager": 50886, "contact": 50886, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3159-50886-10" ] }, { "id": 3854, "title": { "de": "Die Prävalenz von FHH bei PatientInnen mit einem primären Hyperparathyreoidismus", "en": "The Prevalence of FHH in Patients with Primary Hyperparathyroidism" }, "short": "EPATH-FHH", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": 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