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GET /v1/research/project/?format=api&offset=480&ordering=-end_planned
{ "count": 2261, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=500&ordering=-end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=460&ordering=-end_planned", "results": [ { "id": 6760, "title": { "de": "Apolipoprotein AI(apo-AI) Peptid-Lipid Komplexe", "en": "Apolipoprotein AI(apo-AI) Mimetic Peptide Lipid Assemblies" }, "short": "AAMLA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-11-30T01:00:00+01:00", "assignment": "2021-10-22T11:40:29+02:00", "program": 111, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 3, "manager": 83104, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I5703", "ethics_committee": null, "edudract_number": null, "persons": [ "6760-83104-10", "6760-83104-12", "6760-107231-12" ] }, { "id": 8133, "title": { "de": "Alterssuizid in Österreich: Eine Niedrig- und Hochrisikopopulationsstudie basierend auf verknüpften personenbezogenen Registerdaten", "en": "Suicide among older adults in Austria: A low- and high-risk population study based on linked individual-level register data" }, "short": "SAOAA", "url": "https://www.oeaw.ac.at/foerderungen/data-research-austria", "abstract": { "de": "Der Suizid eines Menschen ist eine Tragödie auf individueller Ebene und gleichzeitig ein Problem der öffentlichen Gesundheitsfürsorge auf gesellschaftlicher Ebene. Wenig bekannt ist dabei, dass die Suizidraten sowohl in Österreich als auch allen anderen europäischen Ländern stark mit dem Alter ansteigen. Die allerhöchsten Suizidraten finden sich bei hochaltrigen Männern. Österreich hat gegenwärtig eine der höchsten Suizidraten bei Hochaltrigen in ganz Europa und es wird erwartet, dass die absolute Zahl der Suizide bei älteren Menschen in den nächsten Dekaden aufgrund der fortschreitenden Überalterung der Bevölkerung, insbesondere durch das Älterwerden der Babyboomer-Generation, steigen wird. Die zentrale Forschungsfrage dieses Projekts ist daher, welche Risikofaktoren Suizide bei älteren Menschen in Österreich vorhersagen können, was in weiterer Folge dazu beitragen soll, Präventionsmaßnahmen zu verbessern. Vor dem Hintergrund erstmalig zugänglicher und auf individueller Ebene verknüpfbarer Registerdaten in Österreich durch das Austria Micro Data Center (AMDC) soll im Rahmen dieses Projekts untersucht werden, welche älteren Personengruppen ein erhöhtes Risiko für Suizid haben. Konkret planen wir Risikofaktoren in zwei Bevölkerungsgruppen zu untersuchen: (1) die gesamte ältere Allgemeinbevölkerung (Niedrigrisiko-Ansatz) und (2) ältere gerontopsychiatrische Patient*innen (Hochrisiko-Ansatz). Potentielle Risikofaktoren werden demographische und sozioökonomische Faktoren, körperliche und psychische Erkrankungen, Pflegebedürftigkeit und soziale Isolation umfassen. Dabei werden diese Risikofaktoren nicht nur isoliert voneinander betrachtet, sondern auch deren multiplikativer Effekt, d.h. wenn beispielsweise der Verlust eines Partners mit einer neuen Krebsdiagnose zusammenfällt, untersucht. Mit diesem Forschungsprojekt wollen wir den Alterssuizid in Österreich besser verstehen und damit eine bessere Grundlage für Präventionsmaßnahmen schaffen, und nicht zuletzt die Lebensumstände jener älteren Personen besser zu beleuchten, die keinen anderen Ausweg sehen, als sich selbst (oft mit Gewalt) das Leben zu nehmen. ", "en": "Suicide is a tragedy at the individual level and a serious public health problem at the societal level. Although often overlooked, suicide rates in both Austria and other European countries increase rapidly with age, so that the highest suicide rates tend to show among the oldest old, and here, specifically among men. Austria has one of the highest suicide rates among the oldest old within the EU-27 countries. The high number of suicide deaths among older adults in Austria is not only a present-day concern, but also worrying against the background of population ageing, specifically the ageing of the large baby boomer generation, as this will likely lead to an increase in the absolute number of suicides among older adults in the decades ahead. The main research question of this project therefore is what risk factors can predict old age suicides in Austria, which can subsequently inform suicide prevention efforts. Against the background of newly available individual-level register data linkage in Austria within the Austrian Micro Data Center (AMDC), the aim of this project is to provide new and hitherto unavailable evidence on who among the older population is at an elevated risk of suicide death. Specifically, we seek to identify risk factors in two populations: (1) the whole general older population (low-risk setting) and (2) older psychiatric inpatients (high-risk setting). Risk factors will include demographic and socioeconomic factors, physical and mental health problems, disability and social disconnectedness. We will not only look at these factors in isolation, but also assess whether there are multiplicative effects for suicide risk, that is, when multiple risk factors co-occur at the same time, e.g. when the loss of spouse coincides with a cancer diagnosis. With this research project, we aim to better understand old age suicide in Austria, to inform suicide prevention efforts, and to illuminate the life circumstances of those older adults who see no other way but to (often violently) end their own lives." }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2024-04-10T11:05:11+02:00", "program": 245, "subprogram": null, "organization": 14024, "category": 10, "type": 10, "partner_function": 1, "manager": 89152, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8133-89152-10", "8133-119651-12", "8133-128434-12" ] }, { "id": 7916, "title": { "de": "ARCTECH: Das Potenzial von Archaea nutzbar machen\r\nAusbildung der nächsten Visionäre Europas für eine innovative und nachhaltige Zukunft", "en": "ARCTECH: Harnessing the potential of Archaea\r\nTraining Europe’s next visionaries for an innovative and sustainable future" }, "short": "ARCTECH", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2024-03-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2028-02-29T01:00:00+01:00", "assignment": "2023-12-07T10:05:45+01:00", "program": 209, "subprogram": "HORIZON-MSCA-2022-DN-01", "organization": 14023, "category": 10, "type": 10, "partner_function": 2, "manager": 90021, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101120407", "ethics_committee": null, "edudract_number": null, "persons": [ "7916-90021-10", "7916-99612-12", "7916-100035-12", "7916-104024-12", "7916-109121-12", "7916-100806-12", "7916-106195-12", "7916-111471-12", "7916-128134-12" ] }, { "id": 8562, "title": { "de": "Pilotprojekt Telemedizin in der klinisch-forensischen Untersuchung", "en": "-" }, "short": "Telemedizin_klin-foren_Untersuchungen", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-07-01T02:00:00+02:00", "begin_effective": "2024-06-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-12-12T14:49:41+01:00", "program": null, "subprogram": null, "organization": 14019, "category": 10, "type": 10, "partner_function": 4, "manager": 115441, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8562-115441-10" ] }, { "id": 8710, "title": { "de": "Klinisch-immunologische Charakterisierung der Chronischen Rhinosinusitis", "en": "Clinical-immunological characterization of chronic rhinosinusitis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-05-01T02:00:00+02:00", "begin_effective": "2025-05-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2027-12-31T01:00:00+01:00", "assignment": "2025-03-06T10:01:42+01:00", "program": null, "subprogram": null, "organization": 14066, "category": 10, "type": 10, "partner_function": 4, "manager": 89704, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": 12, "language": null, "funders": [ 457 ], "funder_projectcode": "FIF-A 16-0479/2024-0002", "ethics_committee": null, "edudract_number": null, "persons": [ "8710-89704-10" ] }, { "id": 8503, "title": { "de": "„Mikroperfusion der Haut zur Bestimmung von Veränderungen des Mikromilieus der Haut bei SSc“", "en": "Dermal open flow microperfusion to determine changes in the skin microenvironment in vivo during SSc" }, "short": "SSc_OFM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-11-01T01:00:00+01:00", "begin_effective": "2024-11-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-11-19T13:55:23+01:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 1, "manager": 120271, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2296 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8503-120271-10" ] }, { "id": 7739, "title": { "de": "Evaluierung innovativer molekularer Analyseverfahren und -ansätze zur Überwachung von Antibiotikaresistenzen im Abwasser", "en": "Evaluation of innovative molecular analytical methods and approaches for monitoring antibiotic resistance in wastewater" }, "short": "ARISE", "url": null, "abstract": { "de": "Universelle DNA/RNA Diagnostik. Es soll die technische Realisier- und Leistungsfähigkeit einer neuen universell einsetzbaren molekularbiologischen Nachweisstrategie für die robuste und sensitive DNA/RNA-Diagnostik biologischer („emerging“) Gefährdungen aller Art für das Abwassermonitoring von Morgen demonstriert werden. Dies wird am Beispiel bakterieller Antibiotikaresistenzen (ARB) – auf Basis einer zukunftsweisenden neuartigen molekularbiologischen Toolbox – durchgeführt. Einerseits stellt die ARB-Problematik eine der größten zukünftigen medizinischen globalen Herausforderungen dar (= größte Relevanz), andererseits sind bereits neue leistungsfähige methodische Teillösungen vorhanden, die in kurzer Zeit zur vorgeschlagenen Toolbox kombiniert werden können (= schnelle Umsetzbarkeit). Da diese auf einer Analyse genetischer Sequenzen basiert, ist eine schnelle Ausweitung auf andere biologische Gefährdungen möglich (nach Anpassung der Sampling- und Probenaufarbeitung).\r\nWasserkreislauf-basierter Ansatz. Die vorgeschlagene Nachweisstrategie soll darüber hinaus erstmals simultane Rückschlüsse auf, i) Verbreitung und Infektionsprävalenz des überwachten Bevölkerungskollektivs im Einzugsgebiet der Abwasserentsorgung (d.h. eigentliche Abwasser-epidemiologie - „Upstream-Verfahren“), als auch, ii) die Gefährdung für Mensch- und Natur (z.B. Nutzung als Badewässer, Trinkwasser oder Fischereigewässer) im Zuge der Ausbreitung über den nachgeschalteten Vorfluter und Wasserkreislauf, ermöglichen (d.h. nutzungsbasierte Gefährdungs- und Risikoanalyse der beeinflussten Wasserressource). \r\nOne-Health Monitoring & Management. Da ARB – wie auch viele andere biologische Gefährdungen – humanen und tierischen Ursprung haben und beidseitige Relevanz besitzen können, wird das vorgeschlagene Tool auf alle Arten fäkaler Abwässer entwickelt und ermöglicht eine Zuordnung und Differenzierung (molekulares fäkales Source-Tracking). Dadurch wird eine universell anwendbare Toolbox im Sinne eines One-Health Ansatzes ermöglicht.\r\nBis Dato vorhandene Limitierungen. Verfügbare molekularbiologische Anwendungen sind i.d.R. i) sensitiv und spezifisch, aber auf wenige Targets beschränkt (z.B. qPCR, RT-qPCR), oder, ii) universell, auf viele Targets einsetzbar, aber wenig sensitiv (z.B. gängige Hochdurchsatz-Sequenzierungsmethoden). Zum anderen erfolgt der Nachweis biologischer Gefährdungen im Abwasser bislang weitgehend ohne Berücksichtigung der Quantität und Qualität der fäkalen Belastungssituation (d.h. Ausmaß, Charakteristik und Herkunft der fäkalen mikrobiologischen Beeinflussung).\r\n", "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2023-08-29T16:37:42+02:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 2, "manager": 58733, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "FO999905348", "ethics_committee": null, "edudract_number": null, "persons": [ "7739-54018-11", "7739-58733-10", "7739-103077-12" ] }, { "id": 8570, "title": { "de": "Erforschung der struktureller und elektrischer Eigenschaften zur in-vitro-axonalen Guidance von 3D-strukturierten photokapazitiven Folien", "en": "Exploring the micro-topographic and galvanotropic cues\r\nfor in-vitro axonal guidance on 3D structured photocapacitive\r\nsubstrates" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-12-18T10:24:31+01:00", "program": 207, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 3, "manager": 98848, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8570-98848-10" ] }, { "id": 7490, "title": { "de": "NR4A1 mediierte Regulation der Immuneevasion in Lymphomen", "en": "NR4A1-mediated regulation of immune evasion in lymphoma*" }, "short": "NIEL", "url": null, "abstract": { "de": "Tumorzellen haben eine Reihe von Mechanismen entwickelt, um die immunvermittelte Erkennung und Zerstörung von Tumorzellen zu umgehen bzw. zu unterdrücken. Eine unserer Erkenntnisse ist, dass ein Teil der aggressiven B-Lymphome, maligne Tumore der antikörperproduzierenden Zellen, eine geringe Expression des Transkriptionsfaktors NR4A1 aufweisen. NR4A1 reguliert, wie andere Transkriptionsfaktoren, zahlreiche biologische Prozesse in Zellen. Die Funktion in aggressiven B-Lymphomen ist jedoch bis dato noch nicht untersucht worden. In unserer Vorstudie haben wir herausgefunden, dass eine niedrige NR4A1-Expression mit einer reduzierten Überlebensrate bei Standardtherapie einherging. In unserem Lymphommausmodell konnten wir nachweisen, dass der Verlust von Nr4a1 die Lymphomentwicklung deutlich beschleunigte, begleitet von einer erhöhten Expression immunsuppressiver Oberflächenmoleküle und einem höheren Gehalt an Immunzellen in Mäusen, die ein funktionierendes Immunsystem besaßen, aber nicht in Mausmodellen mit einem nicht funktionierenden Immunsystem. Weitere Analysen deuten darauf hin, dass der Verlust von Nr4a1 mit einer verminderten immunzellvermittelten Zerstörung von Lymphomzellen verbunden ist. Zusammenfassend deuten unsere Daten auf eine tumorsuppressive Funktion von NR4A1 hin, die durch immunregulatorische Eigenschaften bei der Entwicklung aggressiver Lymphome vermittelt wird.\r\nIn dem geplanten Projekt wollen wir mit globalen genetischen Ansätzen aufklären, welche Gene und/oder genetischen Programme durch NR4A1 reguliert werden, sowie mit Hilfe neuartiger Sequenzierungstechnologien die Auswirkungen von NR4A1 auf die Zusammensetzung und die Aktivität der Immunzellen in aggressiven Lymphomen untersuchen. Darüber hinaus wollen wir die Wirksamkeit von Immuntherapien als Einzelwirkstoffe sowie in Kombination (einschließlich neuer Moleküle) in Bezug auf die NR4A1-Expression bei aggressiven Lymphomen funktionell testen. Schließlich werden wir die Daten aus dem präklinischen Modell auf Patientenproben übertragen. Hier werden wir NR4A1, Antigenpräsentation und immunsuppressive Oberflächenmoleküle in unserer DLBCL-Patientenkohorte untersuchen, um unsere Erkenntnisse in einem klinischeren Umfeld zu validieren.\r\nAnhand der Ergebnisse könnten wir einen neuen Mechanismus identifizieren, der wesentlich zur Lymphomentwicklung beiträgt und zur Identifizierung von Lymphompatienten genutzt werden kann, die von einer neuartigen Immuntherapie profitieren könnten.\r\n", "en": "Tumour cells have developed a number of mechanisms to avoid or suppress their recognition, targeting and killing by immune cells. We found out that a part of aggressive B cell lymphomas, a tumour consisting of the antibody-producing cells, exhibited low expression of the transcription factor NR4A1. NR4A1, like other transcription factors, regulates numerous biological processes in cells. However, its function has not been yet investigated in aggressive B cell lymphomas. In our preliminary study, we observed that low NR4A1 levelwas associated with reduced survival in patients treated with standard therapy. In mice with a functional immune system, we showed that loss of Nr4a1 markedly accelerated the development of lymphoma, with increased presence of surface molecules that inhibit immune cells, but also a higher content of these immune cells compared to immunodeficient mouse models. Further, our analyses indicate that loss of Nr4a1 is linked to reduced killing of lymphoma by immune cells. Taken together our data indicate a tumour-suppressive function of NR4A1 mediated by its immune regulatory properties in the development of aggressive lymphomas.\r\nIn the planned project, we aim to elucidate which genes and/or genetic programs are regulated by NR4A1 with global genetic approaches and to investigate the impact of NR4A1 on immune cell composition and activity in aggressive lymphomas using novel sequencing technologies. In addition, our aim is to functionally test the efficacy of immune therapies as single agents as well as in combination (including novel molecules) in relation to the NR4A1 level in aggressive lymphomas. Finally, we will transfer data from the preclinical model to patients samples and investigate NR4A1 expression, antigen presentation, and immune suppressive surface molecules in our DLBCL patient cohort to validate our findings in a more clinical setting.\r\nBased on the finding, we might identify a novel mechanism, which significantly contribute to lymphoma development and which can be used to identify lymphoma patients who may benefit from a novel type of immune therapy. \r\n" }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-05-15T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-10-14T02:00:00+02:00", "assignment": "2023-04-11T15:10:20+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 59183, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P36643", "ethics_committee": null, "edudract_number": null, "persons": [ "7490-100134-12", "7490-59183-10", "7490-79614-12", "7490-82501-12", "7490-85928-12", "7490-111069-12", "7490-130555-12", "7490-131900-12", "7490-122350-12", "7490-122590-12" ] }, { "id": 8532, "title": { "de": "Identifizierung Glykosylierungs-bezogener Biomarker\r\nzur Stratifizierung des Schweregrads beim chronischen Fatigue Syndrom", "en": "Exploring the Glycome: Identifying Glycosylation-Related Biomarkers\r\nfor severity stratification in Chronic Fatigue Syndrome" }, "short": "GlycoExplore-CFS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-02-28T01:00:00+01:00", "assignment": "2024-11-27T12:11:08+01:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 1, "manager": 120271, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1844 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8532-120271-10" ] }, { "id": 8151, "title": { "de": "Das intestinale Mikrobiom eines orthotopen und eines ektopen Hepatoblastom Mausmodelles", "en": "The Intestinal Microbiome in an Orthotopic and Ectopic Tumor Murine Model of Hepatoblastoma" }, "short": "Microbiome in Hepatoblastoma Mouse Model", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2024-04-24T15:59:17+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 1, "manager": 90375, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8151-50778-12", "8151-90375-10", "8151-97866-12" ] }, { "id": 7917, "title": { "de": "Entwicklung einer Immobilisierungsmethode für ein Compound-Screening basierend auf Fluoreszenzmikroskopie in Fadenwürmern", "en": "Establishing an immobilization method for compound screens based on\r\nfluorescence microscopy in nematodes" }, "short": "Immobilisierung_Compound-Screening_WTZ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2023-12-07T12:13:19+01:00", "program": 207, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 1, "manager": 85069, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7917-85069-10" ] }, { "id": 9078, "title": { "de": "Einfluss von Humanmilch-Oligosacchariden auf das Harnmikrobiom in der Schwangerschaft", "en": "Influence of human milk oligosaccharides on the urinary microbiome during pregnancy" }, "short": "Humanmilch_Harnmikrobiom_StadtGraz", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-04-01T02:00:00+02:00", "begin_effective": "2025-04-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2025-07-08T12:54:31+02:00", "program": null, "subprogram": null, "organization": 14064, "category": 10, "type": 10, "partner_function": 4, "manager": 88993, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9078-88993-10" ] }, { "id": 8681, "title": { "de": "Smart and Federated Open data eXchange of citizen-based data donations for clinical research", "en": "Smart and Federated Open data eXchange of citizen-baseddata donations for clinical research " }, "short": "SmartFOX", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2025-02-24T16:54:03+01:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 1, "manager": 99976, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8681-99976-10" ] }, { "id": 7055, "title": { "de": "Lösung des offenen Rätsels von TRPC3 durch Photopharmakologie", "en": "Resolving the open state enigma of TRPC3 by photopharmacology" }, "short": null, "url": null, "abstract": { "de": "• Wider research context / theoretical framework: TRPC3 is a distinct member of TRPC family. This channel is expressed in excitable and non-excitable cells. By non-selectively conducting cations even at its resting state, TRPC3 promotes cellular processes in both health and disease. However, there are only a few modulators of this channel available. To precisely design new therapeutic ligands, it is of high importance to gain knowledge about TRPC3 protein structure and, consequently, its gating mechanism. Recently, two TRPC3 structures were revealed by cryo electron microscopy (cryo-EM). Nonetheless, neither of them captured open pore architecture. Hence, the open conformations is the critical missing piece of information to solve the TRPC3 gating puzzle. This knowledge is essential for comprehension of the molecular function of TRPC3 and definition of possible ligand binding sites to control this channel is health and, especially, disease.\r\n• Hypotheses / research questions / objectives: Here, we propose to succeed in capturing open pore structures of TRPC3 by stabilizing and synchronizing the channels at a high open probability using photochromic ligands and in addition by preserving their lipid environment during the protein preparation for cryo-EM.\r\n• Approach / methods: We will screen two expression systems for suitability to maintain TRPC3 in open conformation. We will utilize photopharmacological tools for a temporal control over TRPC3 gating during protein extraction and cryo-EM. Structural details obtained from cryo-EM will be followed by structure-guided mutagenesis and evaluated in a multifunctional live cell approach combining Ca2+ imaging and electrophysiology.\r\n• Level of originality / innovation: With our project, we will introduce a novel approach to control protein conformations during cryo-EM by photoswitchable ligands. Our work will unravel TRPC3 open architecture and promote the development of new concepts for therapeutic targeting of these channels.\r\n• Primary researchers involved: The research team will include profound experts in TRPC3 electrophysiology and Ca2+ signaling Dr. Oleksandra Tiapko and Dr. Klaus Groschner (Medical University of Graz, Austria), experts in membrane lipids Dr. Anita Emmerstorfer-Augustin (Graz University of Technology) and in structural biology and electron microscopy Dr. Christine Ziegler (University of Regensburg).", "en": "• Wider research context / theoretical framework: TRPC3 is a distinct member of TRPC family. This channel is expressed in excitable and non-excitable cells. By non-selectively conducting cations even at its resting state, TRPC3 promotes cellular processes in both health and disease. However, there are only a few modulators of this channel available. To precisely design new therapeutic ligands, it is of high importance to gain knowledge about TRPC3 protein structure and, consequently, its gating mechanism. Recently, two TRPC3 structures were revealed by cryo electron microscopy (cryo-EM). Nonetheless, neither of them captured open pore architecture. Hence, the open conformations is the critical missing piece of information to solve the TRPC3 gating puzzle. This knowledge is essential for comprehension of the molecular function of TRPC3 and definition of possible ligand binding sites to control this channel is health and, especially, disease.\r\n• Hypotheses / research questions / objectives: Here, we propose to succeed in capturing open pore structures of TRPC3 by stabilizing and synchronizing the channels at a high open probability using photochromic ligands and in addition by preserving their lipid environment during the protein preparation for cryo-EM.\r\n• Approach / methods: We will screen two expression systems for suitability to maintain TRPC3 in open conformation. We will utilize photopharmacological tools for a temporal control over TRPC3 gating during protein extraction and cryo-EM. Structural details obtained from cryo-EM will be followed by structure-guided mutagenesis and evaluated in a multifunctional live cell approach combining Ca2+ imaging and electrophysiology.\r\n• Level of originality / innovation: With our project, we will introduce a novel approach to control protein conformations during cryo-EM by photoswitchable ligands. Our work will unravel TRPC3 open architecture and promote the development of new concepts for therapeutic targeting of these channels.\r\n• Primary researchers involved: The research team will include profound experts in TRPC3 electrophysiology and Ca2+ signaling Dr. Oleksandra Tiapko and Dr. Klaus Groschner (Medical University of Graz, Austria), experts in membrane lipids Dr. Anita Emmerstorfer-Augustin (Graz University of Technology) and in structural biology and electron microscopy Dr. Christine Ziegler (University of Regensburg)." }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-10-31T01:00:00+01:00", "assignment": "2022-06-13T15:55:42+02:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 90337, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": " P 35291", "ethics_committee": null, "edudract_number": null, "persons": [ "7055-90337-10", "7055-116421-12" ] }, { "id": 6571, "title": { "de": "PERSONALISIERUNG DER IMMUNSUPPRESSION DURCH ÜBERWACHUNG DER VIRUSLAST NACH NIERENTRANSPLANTATION - EINE RANDOMISIERTE, KONTROLLIERTE PHASE-II-STUDIE", "en": "PERSONALISATION OF IMMUNOSUPPRESSION BY MONITORING VIRAL LOAD POST KIDNEY\r\nTRANSPLANTATION - A RANDOMISED CONTROLLED PHASE II TRIAL" }, "short": "TTV GUIDE TX", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-01-01T01:00:00+01:00", "begin_effective": "2021-05-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-04-30T02:00:00+02:00", "assignment": "2021-05-11T12:03:53+02:00", "program": 109, "subprogram": null, "organization": 14084, "category": 10, "type": 10, "partner_function": 2, "manager": 74174, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6571-100601-12", "6571-74174-10", "6571-74175-12", "6571-75657-12", "6571-86124-12", "6571-86588-12", "6571-97708-12", "6571-104723-12", "6571-118529-12" ] }, { "id": 6942, "title": { "de": "CBmed: MODUL - Mikroplastik: Eine Gefahr für die menschliche Gesundheit Projekt 3\r\nInteraktion - Gesundheitseffekte - Prävention", "en": "CBmed: MODUL - Microplastic Particles: A Hazard for Human Health Project 3\r\nINTERACTION – HUMAN HEALTH EFFECTS – TREATMENT" }, "short": "MicroONE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2022-03-02T13:48:50+01:00", "program": 94, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 50989, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6942-81091-12", "6942-107131-12", "6942-106674-12", "6942-112689-12", "6942-50989-10", "6942-114553-12", "6942-115621-12", "6942-119169-12", "6942-125874-12", "6942-126494-12", "6942-124112-12" ] }, { "id": 7913, "title": { "de": "NeEDs - necessary decision support system", "en": "NeEDs - necessary decision support system" }, "short": "NeEDs", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2023-12-05T10:18:58+01:00", "program": null, "subprogram": null, "organization": 14076, "category": 10, "type": 10, "partner_function": 4, "manager": 78071, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1040 ], "funder_projectcode": "1.000.072.603", "ethics_committee": null, "edudract_number": null, "persons": [ "7913-78071-10" ] }, { "id": 7215, "title": { "de": "Die Bedeutung von \"Glial Fibrillary Acidic Pretein\" im Plasma als diagnostischer und prognostischer Marker der Hirnalterung und der Alzheimer Krankheit", "en": "The Role of Plasma Glial Fibrillary Acidic Protein as a diagnostic and prognostic marker in brain aging and Alzheimer´s disease" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2022-10-13T14:04:13+02:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 57435, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2269 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7215-57435-10", "7215-73547-11" ] }, { "id": 8561, "title": { "de": "Gewaltambulanz\r\nder Medizinischen Universität Graz und Konzept für die\r\nflächendeckende Versorgung", "en": "-" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-04-01T02:00:00+02:00", "begin_effective": "2024-04-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-12-12T14:44:55+01:00", "program": null, "subprogram": null, "organization": 14019, "category": 10, "type": 10, "partner_function": 4, "manager": 115441, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8561-115441-10" ] } ] }