Project List
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GET /v1/research/project/?format=api&offset=460&ordering=end_effective
{ "count": 2244, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=480&ordering=end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=440&ordering=end_effective", "results": [ { "id": 2537, "title": { "de": "Klinische Relevanz von Keimbahnpolymorphismen in Wnt/Notch/Hedgehog für Prognose bei Kolonkarzinomen", "en": "Clinical impact of germline polymorphisms in Wnt/Notch/Hedgehog for colon cancer outcome" }, "short": "GERMLINE POLYMORPH COLON CANCER", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-08-01T02:00:00+02:00", "begin_effective": "2011-11-01T01:00:00+01:00", "end_planned": "2012-07-31T02:00:00+02:00", "end_effective": "2012-10-31T01:00:00+01:00", "assignment": "2011-07-19T11:01:17+02:00", "program": 79, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 58814, "contact": 58814, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2537-58814-10" ] }, { "id": 3048, "title": { "de": "Exudate Analysis - Literature Research", "en": "Exudate Analysis - Literature Research" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-09-01T02:00:00+02:00", "begin_effective": "2012-09-01T02:00:00+02:00", "end_planned": "2012-11-30T01:00:00+01:00", "end_effective": "2012-11-30T01:00:00+01:00", "assignment": "2012-11-22T13:24:43+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2720, "title": { "de": "Ko-Kultursystem für die frühe Plazentation mit unterschiedlichen Sauerstoffkonzentrationen", "en": "Co-Culture System for early placentation with different oxygen-concentrations" }, "short": "CO-CULTURE SYSTEM EARLY PLACENTATION", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-08-01T02:00:00+02:00", "begin_effective": "2011-12-01T01:00:00+01:00", "end_planned": "2012-07-31T02:00:00+02:00", "end_effective": "2012-11-30T01:00:00+01:00", "assignment": "2012-01-10T12:04:51+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": null, "manager": 58943, "contact": 58943, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2720-58943-10" ] }, { "id": 2040, "title": { "de": "Wirkung chirurgischer und pharmakologischer Interventionen auf das fetale Lungenwachstum bei pulmonaler Hypoplasie", "en": "Impact of surgical and pharmacological interventions on fetal lung growth in pulmonary hypoplasia" }, "short": "IncreaseLungGrowth08", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-12-15T01:00:00+01:00", "begin_effective": "2009-12-15T01:00:00+01:00", "end_planned": "2012-12-15T01:00:00+01:00", "end_effective": "2012-12-15T01:00:00+01:00", "assignment": "2010-01-18T12:45:19+01:00", "program": 24, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 50155, "contact": 50155, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2040-50155-10" ] }, { "id": 2700, "title": { "de": "Einflüsse der transkraniellen Gleichstromstimulation (tDCS) auf Neuroplastizität und motorische Lernleistung", "en": "Influence of tDCS on neuroplasticity and motor learning" }, "short": "ENTRAIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-01-01T01:00:00+01:00", "begin_effective": "2012-01-01T01:00:00+01:00", "end_planned": "2012-04-30T02:00:00+02:00", "end_effective": "2012-12-30T01:00:00+01:00", "assignment": "2011-12-20T14:35:32+01:00", "program": null, "subprogram": "IA angelegt - 20.12.2011, MAE", "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 51814, "contact": 51814, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2700-51814-10" ] }, { "id": 2721, "title": { "de": "Kopfschmerz, Reaktive Sauerstoff und Stickstoff Studie", "en": "Headache, Reactive Oxygen and Nitrogen Study" }, "short": "HEADRON", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-01T02:00:00+02:00", "begin_effective": "2012-01-01T01:00:00+01:00", "end_planned": "2014-09-01T02:00:00+02:00", "end_effective": "2012-12-30T01:00:00+01:00", "assignment": "2012-01-12T09:20:38+01:00", "program": null, "subprogram": null, "organization": 14028, "category": 10, "type": 10, "partner_function": 4, "manager": 50562, "contact": 50562, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2721-50562-10" ] }, { "id": 2434, "title": { "de": "Darmverlängerung durch mechnische Dehnung (MESI)", "en": "MESI: Mechanical Elongation of Small Intestine" }, "short": "MESI", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-01T02:00:00+02:00", "begin_effective": "2011-02-01T01:00:00+01:00", "end_planned": "2012-08-31T02:00:00+02:00", "end_effective": "2012-12-30T01:00:00+01:00", "assignment": "2011-03-02T14:14:05+01:00", "program": null, "subprogram": "Land Steiermark A3", "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 50052, "contact": 50052, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2434-50052-10" ] }, { "id": 261, "title": { "de": "European Leukemia Net", "en": "European Leukemia Net" }, "short": "European Leukemia Net", "url": null, "abstract": { "de": "Leukemias are a challenge to society and a cost factor because of their frequency in all age groups.\r\nThe objective is to integrate the 78 leading leukemia trial groups (CML, AML, ALL, CLL, MDS, CMPD), their 83 interdisciplinary partners (diagnostic, treatment research, registry, guidelines), industry and SMEs across Europe to form a cooperative network for advancements in leukemia-related research and health care.\r\nThe proposed network will have the expertise and critical mass for European added value and world leadership. It will structure European research durably, spread European scientific excellence in the field of leukemias and can start immediately.", "en": "Leukemias are a challenge to society and a cost factor because of their frequency in all age groups.\r\nThe objective is to integrate the 78 leading leukemia trial groups (CML, AML, ALL, CLL, MDS, CMPD), their 83 interdisciplinary partners (diagnostic, treatment research, registry, guidelines), industry and SMEs across Europe to form a cooperative network for advancements in leukemia-related research and health care.\r\nThe proposed network will have the expertise and critical mass for European added value and world leadership. It will structure European research durably, spread European scientific excellence in the field of leukemias and can start immediately." }, "begin_planned": null, "begin_effective": "2004-01-01T01:00:00+01:00", "end_planned": null, "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 21, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 2, "manager": 51344, "contact": 51344, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "261-51344-10", "261-51553-10", "261-52966-12" ] }, { "id": 2332, "title": { "de": "Durchführung der multizentrischen Studie \"Blood Gas Analysis and Buffering in Cardiac Arrest\"", "en": "Blood gas analysis and buffering in Cardiac Arrest" }, "short": "BABICA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-09-01T02:00:00+02:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2011-08-31T02:00:00+02:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2010-10-29T12:04:43+02:00", "program": null, "subprogram": null, "organization": 14069, "category": 10, "type": 10, "partner_function": 4, "manager": 51986, "contact": 51986, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2332-51986-10" ] }, { "id": 1443, "title": { "de": "Targeting oxygen dependent potassium channels - new option for lung cancer?", "en": "Targeting oxygen dependent potassium channels - new option for lung cancer?" }, "short": "OXYGEN_POTASSIUM_CHANNELS_LUNG_CANCER", "url": null, "abstract": { "de": "Das Nicht-kleinzellige Bronchialkarzinom (NSCLC) macht 80% aller Lungentumoren aus. Das Gesamtüberleben ist schlecht, t.w. wegen einer Apoptoseresistenz gegenüber Chemotherapie. Kaliumkanäle regulieren die Apoptose. Die Rolle von pH-und sauerstoffabhängigen Kaliumkanälen beim NSCLC ist weitgehend unbekannt. Einer dieser Kanäle, TASK-1, kontrolliert in pulmonalarteriellen glatten Muskelzellen das Mambranpotential und wurde von unserer Gruppe beschrieben. Das Ziel der Studie ist es, die Expression und funktionelle Bedeutung von solchen Kanälen beim NSCLC zu analysieren. In vitro sollen Proliferation, Apoptose und hypoxieabhängige Adaptation an Zellkulturen und Tumorslices untersucht werden. Patch clamp, Molekularbiologie und Imaging Techniken werden eingesetzt. Zur spezifischen Ausschaltung und Aktivierung von TASK-1 und -3 werden siRNA sowie pharmakologische Methoden verwendet, um die potentielle Relevanz für die NSCLC Therapie zu prüfen und die Chemotherapieresistenz zu überwinden.", "en": "Das Nicht-kleinzellige Bronchialkarzinom (NSCLC) macht 80% aller Lungentumoren aus. Das Gesamtüberleben ist schlecht, t.w. wegen einer Apoptoseresistenz gegenüber Chemotherapie. Kaliumkanäle regulieren die Apoptose. Die Rolle von pH-und sauerstoffabhängigen Kaliumkanälen beim NSCLC ist weitgehend unbekannt. Einer dieser Kanäle, TASK-1, kontrolliert in pulmonalarteriellen glatten Muskelzellen das Mambranpotential und wurde von unserer Gruppe beschrieben. Das Ziel der Studie ist es, die Expression und funktionelle Bedeutung von solchen Kanälen beim NSCLC zu analysieren. In vitro sollen Proliferation, Apoptose und hypoxieabhängige Adaptation an Zellkulturen und Tumorslices untersucht werden. Patch clamp, Molekularbiologie und Imaging Techniken werden eingesetzt. Zur spezifischen Ausschaltung und Aktivierung von TASK-1 und -3 werden siRNA sowie pharmakologische Methoden verwendet, um die potentielle Relevanz für die NSCLC Therapie zu prüfen und die Chemotherapieresistenz zu überwinden." }, "begin_planned": "2008-01-01T01:00:00+01:00", "begin_effective": "2008-01-01T01:00:00+01:00", "end_planned": "2010-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2008-01-10T15:54:34+01:00", "program": 79, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2875, "title": { "de": "s100b bei Migräne", "en": "s100b in migraine" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-07-01T02:00:00+02:00", "begin_effective": "2012-07-01T02:00:00+02:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2012-05-31T12:05:38+02:00", "program": null, "subprogram": null, "organization": 14028, "category": 10, "type": 10, "partner_function": 4, "manager": 51164, "contact": 51164, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2875-51164-10" ] }, { "id": 2570, "title": { "de": "Die dosisabhängige Wirkung von Platelet-rich Plasma auf die Proliferation von Fibroblasten der Rotatorenmanschette ", "en": "Dose related impact of platelet rich plasma (PRP) on human fibroblast proliferation after rotator cuff lesions" }, "short": "PRP for rotator cuff regeneration", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-01T02:00:00+02:00", "begin_effective": "2011-09-01T02:00:00+02:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2011-09-07T15:52:46+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 59379, "contact": 59379, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1270 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2570-59379-10" ] }, { "id": 2342, "title": { "de": "Quantifizierung der orthostatischen Kapazität", "en": "Orthocap - Use of galanin and adrenomedullin responses to quantify orthostatic capacity" }, "short": "Orthocap", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-07-31T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2010-11-22T12:56:50+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 51683, "contact": 51683, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2342-51683-10" ] }, { "id": 2790, "title": { "de": "GaitBase - Ein interdisciplinären Projekt zur erleichterung von Ganganalyse Datenmanagement bei Kindern mit neuromuskulären Erkrankungen", "en": "GaitBase - An interdisciplinary project to simplify management of gait analysis data in children with neuromuscular disease" }, "short": "GaitBase", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-01T02:00:00+02:00", "begin_effective": "2012-04-01T02:00:00+02:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2012-02-15T12:31:01+01:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 1, "manager": 65038, "contact": 65038, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1287 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2790-65038-10" ] }, { "id": 2339, "title": { "de": "Proteomic and microbial profiling of human cervico-vaginal fluid and saliva of pregnant women throughout gestation", "en": "Proteomic and microbial profiling of human cervico-vaginal fluid and saliva of pregnant women throughout gestation" }, "short": "PROTEOMIC PROFILING", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-01T02:00:00+02:00", "begin_effective": "2011-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2010-11-11T13:26:31+01:00", "program": 79, "subprogram": null, "organization": 14064, "category": 10, "type": 10, "partner_function": 4, "manager": 51719, "contact": 51719, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2339-51719-10" ] }, { "id": 1505, "title": { "de": "Genetische Determinaten zerebraler Kleingefäßerkrankung", "en": "Genetic determinants of cerebral small vessel disease" }, "short": "CEREBRALVESSEL_FWF07", "url": null, "abstract": { "de": "Die Kleingefäßerkrankung ist die zweithäufigste endemische Schädigung des alternden Gehirns nach Alzheimer Pathologie. Leukoaraiose und Lakunen sind die Hauptläsionen dieser Entität und können mittels Magnet Resonanz (MR) Tomografie des Gehirns dargestellt werden. Bis zu 90% aller Personen über dem 65.Lebensjahr zeigen Laukaraiose unterschiedlichen Schweregrades.\r\nDas Ziel unserer Studie ist die Komplexität der zerebralen Kleingefäßerkrankung auf genetischer Basis aufzutrennen, um ein besseres Verständnis des Pathomechanismus dieser Läsion zu erhalten. Im ersten Schritt werden wir eine genomweite Assoziationsstudie und ein Feinmapping der Kopplungsregionen auf Chromosom 4 und 17 in der Austrian Stroke Prevention Study Kohorte durchführen. Im zweiten Schritt werden wir Familien aus der Basiskohorte der Austrian Stroke Prevention Study rekrutieren. Die Familienmitglieder werden dem selben Studienprookoll unterzogen, wie die Probanden der Basiskohorte. In dieser Familienstudie werden wir Schätzungen zur Vererblichkeit der verschiedenen Läsionscharakteristika und die genetische Korrelation zwischen diesen Läsionsmerkmalen und ihren Hauptrisikofaktoren berechnen. Das Spektrum möglicher Endophenotypen der zerebraler Kleingefäßerkrankung soll aufgezeigt werden. In der Familienstudie werden wir Gene verifizieren, die mit dieser Hirnschädigung in früheren Studien identifiziert wurden.\r\nDie gleichzeitige Verfügbarkeit einer Familien- und einer populationsbasierenden Kohorte mit identem Protokoll bietet die einmalige Gelegenheit zur Identifizierung relevanter Gene, da Kopplungs- und Assoziationsstudien in Kombination duchgeführt werden können. Die Identifizierung solcher Gene wird unser äußerst unvollständiges pathophysiologisches Verständnis über die zerebrale Kleingefäßerkrankung verbessern und die Entdeckung neuer therapeutischer Ziele ermöglichen.", "en": "Cerebral small vessel disease is the second most common endemic entity of the ageing brain following Alzheimer pathology. Its hallmark lesions are leuko-araiosis and lacunar infarctions, which can be non-invasively depicted with brain magnetic resonance imaging. Up to 90% of persons above the age of 65 years present with leuko-araiosis. Lacunes occur less common with a frequency of 6% to 20%. Decreased mobility of the elderly due to disequilibrium and gait abnormalities, and progressive cognitive impairment up to dementia are frequent clinical sequelae of cerebral microangiopathy. Established risk factors are arterial hypertension and advancing age. There does not exist any established treatment yet which allows to modify the evolution of small vessel disease-related brain damage. \r\nThe heritability of leukoaraiosis volume ranges between 55% and 73%. There are no heritability estimates of other characteristics of white matter lesions such as type and progression are available. Similarly, the heritability of other components of small vessel disease such as lacunes, brain atrophy and microbleeds have not yet been investigated yet. Association studies indicated that the APOE, ACE, eNOS, MTHFR genes might be related to these pathologies. We found positive associations with APOE, PON1 as well as the AGT, with considerable evidence for a causal relationship for the latter. Very recently, the results of the first genome wide scan on white matter lesion volume have been reported by the Framingham Heart Study describing a significant LOD score on chromosome 4 and a suggestive LOD score for linkage on chromosome 17.\r\n \tThe aim of our study is to genetically dissect the complexity of cerebral small vessel disease in order to better understand the pathomechanisms leading to these lesions. First we will apply genome wide association as well as fine map the linkage regions on Chr 4 and 17 in the the Austrian Stroke Prevention Study cohort, which is one of the largest community-dwelling studies on cerebral small vessel disease and the study with the longest MRI follow up so far. Second, we will recruit families ascertained through participants of the Austrian Stroke Prevention Study. Family members will undergo the same study protocol including brain MRI as the probands in the population based cohort. In the family based cohort we will estimate heritability of and genetic correlation between different lesion characteristics of cerebral small vessel disease and its major risk factors. We aim to develop a spectrum of possible endophenotypes for cerebral small vessel disease. In the family based cohort we also aim to verify genes associated with cerebral small vessel disease in previous studies. \r\nThe co-existence of a family and a population based cohort characterized with identical study protocol will offer a unique and outstanding resource to identify genes by allowing for the combined use of linkage and association. Knowledge of genes involved in cerebral small vessel disease will improve our understanding of the pathogenesis of these lesions and will possibly facilitate the development of novel therapeutic targets.\r\n" }, "begin_planned": "2007-11-01T01:00:00+01:00", "begin_effective": "2008-05-01T02:00:00+02:00", "end_planned": "2010-10-31T02:00:00+02:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2008-03-31T18:04:38+02:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51912, "contact": 51912, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P20545", "ethics_committee": null, "edudract_number": null, "persons": [ "1505-51912-10" ] }, { "id": 2397, "title": { "de": "Körperliche Aktivität, Fitness und Hirnaltern ", "en": "Physical activity, fitness and brain aging" }, "short": "FITNESS AND BRAIN AGING", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-05-01T02:00:00+02:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2011-10-20T02:00:00+02:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2011-02-07T14:46:33+01:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51912, "contact": 51912, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2397-51912-10" ] }, { "id": 2220, "title": { "de": "Stratifizierung genetischer Veränderungen von malignen Kindertumoren - Grundlage für eine personalisierte Therapie", "en": "Stratifizierung genetischer Veränderungen von malignen Kindertumoren - Grundlage für eine personalisierte Therapie" }, "short": "MALIGNE KINDERTUMORE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-07-01T02:00:00+02:00", "end_planned": "2010-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2010-06-09T10:58:03+02:00", "program": null, "subprogram": "MAE: IANr. eingetragen (01.06.2010)", "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 52569, "contact": 52569, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2220-52569-10" ] }, { "id": 1734, "title": { "de": "Verkalkung von Gefäßen und Knochen bei NierentransplantationspatientInnen [Regulierung der Kalzifizierung bei NierentransplantationspatientInnen]", "en": "Verkalkung von Gefäßen und Knochen bei NierentransplantationspatientInnen [Regulierung der Kalzifizierung bei NierentransplantationspatientInnen]" }, "short": "Verkalkung bei Nierentransplantationen", "url": null, "abstract": { "de": "Kalzifizierung tritt physiologisch im Knochen und pathophysiologisch im Gefäßsystem auf. Kardiovaskuläre Erkrankungen sind eine Haupt-Todesursache von Nierenerkrankten und sind entscheidend für die Durchführbarkeit von Nierentransplantationen (RTX). Das derezeitige Wissen um die Regulation der Kalzifizierung in Knochen und Gefäßsystem bei RTX-Patienten ist fragmentarisch.\r\n\r\nDiese offene, kontrollierte, monozentrische Studie untersucht die Regulation der Kalzifizierung im Knochen- und Gefäßsystem bei PatientInnen mit RTX.\r\nUnsere Fragestellung zielt auf Unterschiede der Expressionslevels von Regulatoren der Kalzifizierung in beiden Gewebstypen und im Vergleich von athero- und mediasklerotischen Gefäßen.\r\nWir erwarten uns Einblick in Kalzifizierungsmechanismen und mögliche klinische Aspekte für Diagnose und Therapie bei diesen HochrisikopatientInnen.", "en": "Kalzifizierung tritt physiologisch im Knochen und pathophysiologisch im Gefäßsystem auf. Kardiovaskuläre Erkrankungen sind eine Haupt-Todesursache von Nierenerkrankten und sind entscheidend für die Durchführbarkeit von Nierentransplantationen (RTX). Das derezeitige Wissen um die Regulation der Kalzifizierung in Knochen und Gefäßsystem bei RTX-Patienten ist fragmentarisch.\r\n\r\nDiese offene, kontrollierte, monozentrische Studie untersucht die Regulation der Kalzifizierung im Knochen- und Gefäßsystem bei PatientInnen mit RTX.\r\nUnsere Fragestellung zielt auf Unterschiede der Expressionslevels von Regulatoren der Kalzifizierung in beiden Gewebstypen und im Vergleich von athero- und mediasklerotischen Gefäßen.\r\nWir erwarten uns Einblick in Kalzifizierungsmechanismen und mögliche klinische Aspekte für Diagnose und Therapie bei diesen HochrisikopatientInnen." }, "begin_planned": "2009-01-01T01:00:00+01:00", "begin_effective": "2009-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2009-01-21T15:49:20+01:00", "program": 79, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": 51982, "contact": 51982, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1734-51982-10", "1734-57544-12" ] }, { "id": 2680, "title": { "de": "Psoriasis-Therapieregister-Österreich", "en": "Psoriasis Registry Austria" }, "short": "Psoriasis Registry Austria", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-01-01T01:00:00+01:00", "begin_effective": "2012-01-01T01:00:00+01:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2011-12-12T16:28:51+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 51618, "contact": 51618, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1161 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2680-51618-10" ] } ] }