Project List

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    "count": 2329,
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    "results": [
        {
            "id": 2031,
            "title": {
                "de": "Genetic variants in the RAD51, BRCA1 and BRCA2 genes as predictors of radiation response and toxicity in prostate cancer patients",
                "en": "Genetic variants in the RAD51, BRCA1 and BRCA2 genes as predictors of radiation response and toxicity in prostate cancer patients"
            },
            "short": "GENETIC_PROSTATE_CANCER_OeNB",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-01-11T15:12:11+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14060,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50495,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2031-50495-10",
                "2031-50910-12"
            ]
        },
        {
            "id": 2342,
            "title": {
                "de": "Quantifizierung der orthostatischen Kapazität",
                "en": "Orthocap - Use of galanin and adrenomedullin responses to quantify orthostatic capacity"
            },
            "short": "Orthocap",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2009-07-31T02:00:00+02:00",
            "begin_effective": "2010-12-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2012-12-31T01:00:00+01:00",
            "assignment": "2010-11-22T12:56:50+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51683,
            "contact": 51683,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                416
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2342-51683-10"
            ]
        },
        {
            "id": 2498,
            "title": {
                "de": "Die Rolle von Metalloproteasen und Endothelin im ersten Schwangerschaftstrimester",
                "en": "The role of metalloproteinases and endothelin in the first trimester of pregnancy"
            },
            "short": "METALLPROTEINASES_ENDOTHELIN_PREGNANCY",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-07-01T02:00:00+02:00",
            "begin_effective": "2011-07-01T02:00:00+02:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2011-06-16T12:49:53+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14038,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2095,
            "title": {
                "de": "Purkinje Topology",
                "en": "Purkinje Topology"
            },
            "short": "PURKINJE TOPOLOGY",
            "url": null,
            "abstract": {
                "de": "Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. ",
                "en": "Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. "
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-02-09T12:53:47+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50967,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                894
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2095-50967-10"
            ]
        },
        {
            "id": 2261,
            "title": {
                "de": "Immune responses to mental stress in patients with malignant melanoma",
                "en": "Immune responses to mental stress in patients with malignant melanoma"
            },
            "short": "MENTAL STRESS_MALIGNANT MELANOMA",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-07-01T02:00:00+02:00",
            "begin_effective": "2010-10-01T02:00:00+02:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-09-30T02:00:00+02:00",
            "assignment": "2010-08-05T16:54:16+02:00",
            "program": 79,
            "subprogram": null,
            "organization": 14047,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 52274,
            "contact": 52274,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2261-60040-11",
                "2261-60388-12",
                "2261-52274-10"
            ]
        },
        {
            "id": 2788,
            "title": {
                "de": "Scanningbewegungen des Kopfes als Ausdruck des Schauverhaltens am gehenden Patienten im Low vision Bereich: Entwicklung der Analysemethode und Standardisierung",
                "en": "Headscanning in Mobility Testing"
            },
            "short": "Headscanning in Mobility Testing",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-05-01T02:00:00+02:00",
            "begin_effective": "2011-05-01T02:00:00+02:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2012-02-14T15:16:48+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14043,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 3,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                938
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 1734,
            "title": {
                "de": "Verkalkung von Gefäßen und Knochen bei NierentransplantationspatientInnen [Regulierung der Kalzifizierung bei NierentransplantationspatientInnen]",
                "en": "Verkalkung von Gefäßen und Knochen bei NierentransplantationspatientInnen [Regulierung der Kalzifizierung bei NierentransplantationspatientInnen]"
            },
            "short": "Verkalkung bei Nierentransplantationen",
            "url": null,
            "abstract": {
                "de": "Kalzifizierung tritt physiologisch im Knochen und pathophysiologisch im Gefäßsystem auf. Kardiovaskuläre Erkrankungen sind eine Haupt-Todesursache von Nierenerkrankten und sind entscheidend für die Durchführbarkeit von Nierentransplantationen (RTX). Das derezeitige Wissen um die Regulation der Kalzifizierung in Knochen und Gefäßsystem bei RTX-Patienten ist fragmentarisch.\r\n\r\nDiese offene, kontrollierte, monozentrische Studie untersucht die Regulation der Kalzifizierung im Knochen- und Gefäßsystem bei PatientInnen mit RTX.\r\nUnsere Fragestellung zielt auf Unterschiede der Expressionslevels von Regulatoren der Kalzifizierung in beiden Gewebstypen und im Vergleich von athero- und mediasklerotischen Gefäßen.\r\nWir erwarten uns Einblick in Kalzifizierungsmechanismen und mögliche klinische Aspekte für Diagnose und Therapie bei diesen HochrisikopatientInnen.",
                "en": "Kalzifizierung tritt physiologisch im Knochen und pathophysiologisch im Gefäßsystem auf. Kardiovaskuläre Erkrankungen sind eine Haupt-Todesursache von Nierenerkrankten und sind entscheidend für die Durchführbarkeit von Nierentransplantationen (RTX). Das derezeitige Wissen um die Regulation der Kalzifizierung in Knochen und Gefäßsystem bei RTX-Patienten ist fragmentarisch.\r\n\r\nDiese offene, kontrollierte, monozentrische Studie untersucht die Regulation der Kalzifizierung im Knochen- und Gefäßsystem bei PatientInnen mit RTX.\r\nUnsere Fragestellung zielt auf Unterschiede der Expressionslevels von Regulatoren der Kalzifizierung in beiden Gewebstypen und im Vergleich von athero- und mediasklerotischen Gefäßen.\r\nWir erwarten uns Einblick in Kalzifizierungsmechanismen und mögliche klinische Aspekte für Diagnose und Therapie bei diesen HochrisikopatientInnen."
            },
            "begin_planned": "2009-01-01T01:00:00+01:00",
            "begin_effective": "2009-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2012-12-31T01:00:00+01:00",
            "assignment": "2009-01-21T15:49:20+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14073,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51982,
            "contact": 51982,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "1734-51982-10",
                "1734-57544-12"
            ]
        },
        {
            "id": 2609,
            "title": {
                "de": "Hepcidin im Rahmen von Sepsis und Adipositas",
                "en": "The Role of Hepcidin in Sepsis and Obesity"
            },
            "short": "HEPCIDIN_SEPSIS_ADIPOSITAS",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-07-01T02:00:00+02:00",
            "begin_effective": "2011-10-01T02:00:00+02:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2012-06-30T02:00:00+02:00",
            "assignment": "2011-10-06T15:38:08+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14049,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50778,
            "contact": 50778,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2609-50778-10"
            ]
        },
        {
            "id": 1716,
            "title": {
                "de": "Nano-Health: Nano-structured materials for drug targeting, release and imaging",
                "en": "Nano-Health: Nano-structured materials for drug targeting, release and imaging"
            },
            "short": "NANO-HEALTH",
            "url": null,
            "abstract": {
                "de": "The increasing incidence of cancer and of degenerative diseases, the latter uncreasingly in relatively young patients, calls for a new healthcare model that is more proactive (detects asymptomatic disease when it is more amenable to treatment), more personalised (based on the growing knowledge about the molecular mechanisms underlying disease), less traumatic and more targeted (non/minimally invasively and specifically treats the affected tissue or organ(s)) and that allows more informed interventions (following of the progress of therapy and disease reoccurrence in as close to real time as possible).\r\nThis prolongation of NANO-HEALTH will build on the work done to date to develop new NM-based solutions for targeted drug delivery and imaging. The following topics will be pursued:\r\n*Further development of thiomers for oral delivery of active substances\r\n*An industrial production process for nano-thiomers\r\n*Development of targeted imaging for cancer using MRI\r\n*Stem cell tracking in vivo\r\n*Atherosclerotic plaque detection\r\n*Chronic nanotoxicity",
                "en": "The increasing incidence of cancer and of degenerative diseases, the latter uncreasingly in relatively young patients, calls for a new healthcare model that is more proactive (detects asymptomatic disease when it is more amenable to treatment), more personalised (based on the growing knowledge about the molecular mechanisms underlying disease), less traumatic and more targeted (non/minimally invasively and specifically treats the affected tissue or organ(s)) and that allows more informed interventions (following of the progress of therapy and disease reoccurrence in as close to real time as possible).\r\nThis prolongation of NANO-HEALTH will build on the work done to date to develop new NM-based solutions for targeted drug delivery and imaging. The following topics will be pursued:\r\n*Further development of thiomers for oral delivery of active substances\r\n*An industrial production process for nano-thiomers\r\n*Development of targeted imaging for cancer using MRI\r\n*Stem cell tracking in vivo\r\n*Atherosclerotic plaque detection\r\n*Chronic nanotoxicity"
            },
            "begin_planned": "2009-01-01T01:00:00+01:00",
            "begin_effective": "2009-03-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2012-02-28T01:00:00+01:00",
            "assignment": "2009-01-14T14:15:30+01:00",
            "program": null,
            "subprogram": "Nano-Initiative",
            "organization": 28392,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 54033,
            "contact": null,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                416
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "1716-54033-10"
            ]
        },
        {
            "id": 2550,
            "title": {
                "de": "Endothelin und Matrixmetalloproteinasen im ersten Schwangerschaftstrimester",
                "en": "Endothelin and matrix metalloproteinases in the first trimester of pregnancy"
            },
            "short": "EndothelMatrix",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-08-01T02:00:00+02:00",
            "begin_effective": "2011-08-01T02:00:00+02:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2011-08-02T14:12:12+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14038,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2431,
            "title": {
                "de": "Genetic predisposition to therapy-related myeloid neoplasms: involvement of the Fanconi anemia/BRCA pathway?",
                "en": "Genetic predisposition to therapy-related myeloid neoplasms: involvement of the Fanconi anemia/BRCA pathway?"
            },
            "short": "FANCONI ANEMIA BRCA",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2013-07-31T02:00:00+02:00",
            "assignment": "2011-02-28T11:28:49+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14082,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51857,
            "contact": 51857,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2431-77371-12",
                "2431-77615-12",
                "2431-51857-10",
                "2431-50116-12"
            ]
        },
        {
            "id": 2384,
            "title": {
                "de": "Mobile Teledermatologie in der Behandlung von Akne-Patienten",
                "en": "Use of Mobile Teledermatology in the Care of Acne Patients"
            },
            "short": "Mobile Acne Care",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-04-01T02:00:00+02:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2012-12-31T01:00:00+01:00",
            "assignment": "2011-01-24T15:38:08+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14047,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51711,
            "contact": 51711,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2384-51711-10"
            ]
        },
        {
            "id": 2340,
            "title": {
                "de": "Die Bedeutung des gluconeogenetischen Enzyms Phosphoenolpyruvat Carboxykinase (PEPCK) für das Tumorwachstum",
                "en": "The role of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) in cancer growth"
            },
            "short": "PEPCK",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-09-01T02:00:00+02:00",
            "begin_effective": "2010-12-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2012-03-31T02:00:00+02:00",
            "assignment": "2010-11-17T10:58:29+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14087,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 57557,
            "contact": 57557,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2340-57557-10"
            ]
        },
        {
            "id": 2093,
            "title": {
                "de": "Isolation of Side Population Cells in Human Soft Tissue Sarcomas",
                "en": "Isolation of Side Population Cells in Human Soft Tissue Sarcomas"
            },
            "short": "ISOLATION OF SIDE POP CELLS ",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-02-09T12:52:51+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14052,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50696,
            "contact": 50696,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                894
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2093-50696-10"
            ]
        },
        {
            "id": 2023,
            "title": {
                "de": "Induction of immunological changes by endoluminal photodynamic therapy (PDT) for esophageal carcinoma",
                "en": "Induction of immunological changes by endoluminal photodynamic therapy (PDT) for esophageal carcinoma"
            },
            "short": "PDT_ESOPHAGEAL_CARCINOMA",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2009-12-18T12:29:42+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14077,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51615,
            "contact": 51615,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2023-62056-12",
                "2023-51615-10",
                "2023-51618-12"
            ]
        },
        {
            "id": 2192,
            "title": {
                "de": "Akupressur-Stimulationsequipment zur emotionalen Entlastung von Menschen mit geistiger Behinderung",
                "en": "Akupressur-Stimulationsequipment zur emotionalen Entlastung von Menschen mit geistiger Behinderung"
            },
            "short": "AKUPRESSUR_STIMULATION",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2013-12-31T01:00:00+01:00",
            "assignment": "2010-05-03T14:28:49+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14044,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51073,
            "contact": 51073,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2192-51073-10"
            ]
        },
        {
            "id": 1821,
            "title": {
                "de": "Nano-Health: Nano-Plaque-Extension",
                "en": "Nano-Health: Nano-Plaque-Extension"
            },
            "short": "Nano-Plaque-Extension",
            "url": null,
            "abstract": {
                "de": "The increasing incidence of cancer and of degenerative diseases, the latter increasingly in relatively young patientes, call for a new healthcare model that is more proactive, i.e. that detects disease pre-symptomatically when it is more amenable to treatment, more personalised, i.e. based on the growing knowledge about the molecular mechanisms underlying disease, less traumatic and more targeted, i.e. that non-invasively or minimally invasively and specifically treats the affected tissue or organ(s) and allows more informed interventions, i.e. That enables the progress of therapy and relapse to be followed in as close to real time as possible.\r\nThe extended project will build on the achievements of NANO-HEALTH made to date. Within the first two years an NP platform based on 4 different types of NPs was elaborated and optimised for drug delivery and imaging. All NPs were characterised in detail by physico-chemical and chemical methods. Starting from this platform, the most promising NPs were optimised for oral drug delivery, for a depot formulation of Vasoactive Intestinal Peptide (VIP), for contrast media using MRI and Spect/PET and to trace stem cells in vivo and for the early detection of atherosclerotic plaque. Several proof-of-concept studies were performed from the end of year 2 up to now (3 years and 3 months).\r\n\r\nThe prolongation of NANO-HEALTH year 5 to 7 will build on the work done to date to develop new NM-based solutions for targeted drug delivery and imaging. The following topics will be pursued:\r\n*Further development of thiomers for oral and topical (depot)delivery of active substances\r\n*(Based on the successful results obtained so far) large scale production processes for nano-thiomers and PLA-HSA-based NPs\r\n*Development of targeted imaging for cancer using MRI\r\n*Stem cell tracking in vivo\r\n*Atherosclerotic plaque detection\r\n*Chronic nanotoxicity",
                "en": "The increasing incidence of cancer and of degenerative diseases, the latter increasingly in relatively young patientes, call for a new healthcare model that is more proactive, i.e. that detects disease pre-symptomatically when it is more amenable to treatment, more personalised, i.e. based on the growing knowledge about the molecular mechanisms underlying disease, less traumatic and more targeted, i.e. that non-invasively or minimally invasively and specifically treats the affected tissue or organ(s) and allows more informed interventions, i.e. That enables the progress of therapy and relapse to be followed in as close to real time as possible.\r\nThe extended project will build on the achievements of NANO-HEALTH made to date. Within the first two years an NP platform based on 4 different types of NPs was elaborated and optimised for drug delivery and imaging. All NPs were characterised in detail by physico-chemical and chemical methods. Starting from this platform, the most promising NPs were optimised for oral drug delivery, for a depot formulation of Vasoactive Intestinal Peptide (VIP), for contrast media using MRI and Spect/PET and to trace stem cells in vivo and for the early detection of atherosclerotic plaque. Several proof-of-concept studies were performed from the end of year 2 up to now (3 years and 3 months).\r\n\r\nThe prolongation of NANO-HEALTH year 5 to 7 will build on the work done to date to develop new NM-based solutions for targeted drug delivery and imaging. The following topics will be pursued:\r\n*Further development of thiomers for oral and topical (depot)delivery of active substances\r\n*(Based on the successful results obtained so far) large scale production processes for nano-thiomers and PLA-HSA-based NPs\r\n*Development of targeted imaging for cancer using MRI\r\n*Stem cell tracking in vivo\r\n*Atherosclerotic plaque detection\r\n*Chronic nanotoxicity"
            },
            "begin_planned": "2009-03-01T01:00:00+01:00",
            "begin_effective": "2009-03-01T01:00:00+01:00",
            "end_planned": "2012-01-28T01:00:00+01:00",
            "end_effective": "2012-02-28T01:00:00+01:00",
            "assignment": "2009-05-18T13:05:25+02:00",
            "program": null,
            "subprogram": "Nano-Health Verlängerung",
            "organization": 14028,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 52854,
            "contact": 52854,
            "status": 2,
            "research": 3,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                416
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "1821-52854-10"
            ]
        },
        {
            "id": 2365,
            "title": {
                "de": "Plasmakonzentration und genetische Polymorphismen von PCSK9 in Patienten mit koronarer Herzkrankheit",
                "en": "Plasma concentration and polymorphisms of PCSK9 in patients with coronary artery disease "
            },
            "short": "PCSK9",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-01-01T01:00:00+01:00",
            "end_planned": "2012-01-31T01:00:00+01:00",
            "end_effective": "2012-01-31T01:00:00+01:00",
            "assignment": "2010-12-20T12:47:35+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14028,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50886,
            "contact": 50886,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2365-50886-10"
            ]
        },
        {
            "id": 2039,
            "title": {
                "de": "Wilms Tumor Development as a Mirror of Nephrogenesis - The Role of Imprinted Genes",
                "en": "Wilms Tumor Development as a Mirror of Nephrogenesis - The Role of Imprinted Genes"
            },
            "short": "WILMS TUMOR NEPHROGENESIS",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-02-01T01:00:00+01:00",
            "begin_effective": "2010-02-01T01:00:00+01:00",
            "end_planned": "2012-01-31T01:00:00+01:00",
            "end_effective": "2012-06-30T02:00:00+02:00",
            "assignment": "2010-01-18T10:41:24+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14020,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 52569,
            "contact": 52569,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2039-52569-10"
            ]
        },
        {
            "id": 2024,
            "title": {
                "de": "Non-invasive monitoring of tissue rejection after heart transplantation",
                "en": "Non-invasive monitoring of tissue rejection after heart transplantation"
            },
            "short": "TISSUE REJECTION HEART TRANSPLANT",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-02-01T01:00:00+01:00",
            "begin_effective": "2010-02-01T01:00:00+01:00",
            "end_planned": "2012-01-31T01:00:00+01:00",
            "end_effective": "2012-12-31T01:00:00+01:00",
            "assignment": "2009-12-18T14:24:22+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14073,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50874,
            "contact": 50874,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2024-50874-10"
            ]
        }
    ]
}