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GET /v1/research/project/?format=api&offset=420&ordering=-end_effective
{ "count": 2244, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=440&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=400&ordering=-end_effective", "results": [ { "id": 8137, "title": { "de": "MindLeap: Kognitionsmessung im Zeitalter von Virtual Reality", "en": "MindLeap: Measuring cognition in the age of virtual reality" }, "short": "MindLeap", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-04-01T02:00:00+02:00", "begin_effective": "2024-04-01T02:00:00+02:00", "end_planned": "2025-04-30T02:00:00+02:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-04-11T14:57:53+02:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 3, "manager": 79733, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8137-79733-10" ] }, { "id": 5865, "title": { "de": "Zonulin und Properdin zur Regulation der Darmbarriere", "en": "ZONULIN OR PROPERDIN TO REGULATE THE GUT BARRIER?" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-09-01T02:00:00+02:00", "begin_effective": "2019-09-01T02:00:00+02:00", "end_planned": "2020-08-31T02:00:00+02:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2019-07-16T16:10:36+02:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 50989, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-44", "ethics_committee": null, "edudract_number": null, "persons": [ "5865-50989-10" ] }, { "id": 7889, "title": { "de": "Magnetische molekularimprintete Polymere als eine Platform für den Wirkstofftransport", "en": "Magnetic Molecularly Imprinted Polymers as a Platform for Drug Delivery\r\n" }, "short": "MMIPP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2023-11-20T11:36:13+01:00", "program": 207, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 2, "manager": 113130, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "FR 05/2024", "ethics_committee": null, "edudract_number": null, "persons": [ "7889-113130-10" ] }, { "id": 8054, "title": { "de": "Ernährungsgewohnheiten von Patient*innen mit \r\nchronisch-entzündlichen Darmerkrankungen \r\nin Österreich und Deutschland", "en": "Diet and Nutrition among patients with inflammatory bowel disease in Austria and Germany" }, "short": "Nutrition IBD Study", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-03-01T01:00:00+01:00", "begin_effective": "2024-03-01T01:00:00+01:00", "end_planned": "2024-10-01T02:00:00+02:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-02-21T10:50:23+01:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 3, "manager": 53167, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 203 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8054-74515-12", "8054-53167-10", "8054-53167-12" ] }, { "id": 7959, "title": { "de": "Zusammensetzung und Funktion von Immunzellen bei Patient*innen mit und ohne steroidrefraktärer akuter und chronischer Graft-versus-Host-Krankheit nach allogener hämatopoetischer Zelltransplantation", "en": "Immune cell composition and function in patients with and without steroid-refractory acute and chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation" }, "short": "Immune cell composition in GVHD", "url": null, "abstract": { "de": null, "en": "One of the most serious life-threatening complications of allogeneic hematopoietic stem cell transplantation (allo-HCT) is acute and chronic graft-versus-host disease (GVHD). (1,2) The established first-line therapy of acute GVHD is methylprednisolone with an initial dose of 2 mg/kg body weight per day. But, only half of all patients respond to first-line therapy and the so-called steroid-refractory GVHD (SR-GVHD) is associated with a poor long-term prognosis. There is still an urgent need for biomarkers that predict response to glucocorticoid therapy. In a retrospective study we showed that cellular infiltrates of immune cells, like innate lymphoid cells (ILCs) and tissue-resident memory T cells (TRMs), differ at onset of gastrointestinal (GI) GVHD in patients who subsequently respond to glucocorticoid therapy compared to patients developing steroid-refractory disease. Based on these preliminary data, we hypothesize that GVHD affects the composition of immune cell populations in affected tissues, such as skin and GI tract, and cellular and molecular profiles of immune cells from peripheral blood (PB) and tissue biopsies, as well as the GI microbiome, may predict lack of response to glucocorticoid therapy. Furthermore, these cellular and molecular profiles may be prognostic for immune reconstitution after allo-HCT. Therefore, the aim of this study is to identify cellular and molecular profiles of GVHD in patients. \r\nFor this purpose, we will prospectively collect clinical data of patients undergoing allo-HCT at the Clinical Division of Hematology at the Medical University/University Hospital Graz, to create a database and compare patient’s clinical course with immune cell composition as well as function/activation state of the PB determined by flow cytometry and cytokine production, as we GI microbiome analysis and tissue samples (skin and GI) obtained from routine clinical biopsies using immunofluorescence, immunohistochemistry and High-Definition Spatial Transcriptomics (HDST). Results of blood and tissue immune cell analyses, cytokines and data from GI microbiome will be compared to the cli nical data on occurrence and severity of GVHD, response to GVHD therapy and patient outcome.\r\n" }, "begin_planned": "2023-11-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-10-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-01-04T15:27:07+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 82501, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894, 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7959-100134-12", "7959-59183-12", "7959-82501-10", "7959-111069-12" ] }, { "id": 6618, "title": { "de": "Programmlinie Therapie: The Better Life in Osteoarthritis Registry-Projects", "en": "Programe Therapy: The Better Life in Osteoarthritis Registry-Projects" }, "short": "BLOAR", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-01-01T01:00:00+01:00", "begin_effective": "2021-01-01T01:00:00+01:00", "end_planned": "2021-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2021-06-15T11:02:24+02:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 2, "manager": 53560, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 19 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6618-53560-10", "6618-77590-12" ] }, { "id": 6963, "title": { "de": "Schwere Immunzytopenie: Register- und Biomarkersignaturstudie", "en": "Severe immune cytopenia: registry and biomarker signature study" }, "short": "sic-reg.org", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-04-01T02:00:00+02:00", "begin_effective": "2022-04-01T02:00:00+02:00", "end_planned": "2024-03-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2022-03-17T15:18:02+01:00", "program": null, "subprogram": null, "organization": 14092, "category": 10, "type": 10, "partner_function": 4, "manager": 85188, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-78", "ethics_committee": null, "edudract_number": null, "persons": [ "6963-85188-10" ] }, { "id": 6586, "title": { "de": "L-ornithin -L-aspertat und das Darm-Mikrobiom bei Zirrhose", "en": "L-ornithine-L-aspertate and the gut microbiome in liver cirrhosis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-05-01T02:00:00+02:00", "begin_effective": "2021-05-01T02:00:00+02:00", "end_planned": "2021-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2021-05-19T12:43:39+02:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 50989, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-59", "ethics_committee": null, "edudract_number": null, "persons": [ "6586-50989-10" ] }, { "id": 7917, "title": { "de": "Entwicklung einer Immobilisierungsmethode für ein Compound-Screening basierend auf Fluoreszenzmikroskopie in Fadenwürmern", "en": "Establishing an immobilization method for compound screens based on\r\nfluorescence microscopy in nematodes" }, "short": "Immobilisierung_Compound-Screening_WTZ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2023-12-07T12:13:19+01:00", "program": 207, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 1, "manager": 85069, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7917-85069-10" ] }, { "id": 5883, "title": { "de": "Etablierung von Zelllinien seltener Tumorerkrankungen ", "en": "Establishment of rare cancer cell lines" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-05-01T02:00:00+02:00", "begin_effective": "2019-05-01T02:00:00+02:00", "end_planned": "2020-05-01T02:00:00+02:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2019-08-12T11:20:23+02:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 50826, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-39", "ethics_committee": null, "edudract_number": null, "persons": [ "5883-106294-12", "5883-109142-12", "5883-50826-10", "5883-122850-12" ] }, { "id": 7300, "title": { "de": "QCI: Proof of Concept – Secure Connectivity Austria", "en": "QCI: Proof of Concept – Secure Connectivity Austria" }, "short": "QCI-CAT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-10-01T02:00:00+02:00", "begin_effective": "2023-01-01T01:00:00+01:00", "end_planned": "2025-03-31T02:00:00+02:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2022-12-14T15:09:22+01:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10, 999 ], "funder_projectcode": "101091642", "ethics_committee": null, "edudract_number": null, "persons": [ "7300-51663-10" ] }, { "id": 8188, "title": { "de": "Pilztranslokation über den Darm gemessen durch 1,3-Beta-D-Glukan und seine Rolle in Patient:innen mit Leberzirrhose", "en": "Gut fungal translocation measured by 1,3-Beta-D-Glucan and its role in patients with liver cirrhosis" }, "short": "BDG-Cirrhosis", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-08-01T02:00:00+02:00", "begin_effective": "2024-08-01T02:00:00+02:00", "end_planned": "2026-01-01T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-05-07T15:35:19+02:00", "program": null, "subprogram": null, "organization": 29164, "category": 10, "type": 10, "partner_function": 4, "manager": 115781, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 203 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8188-115781-10" ] }, { "id": 5380, "title": { "de": "Progressionsbeurteilung bei metastasierenden neuroendokrinen Neoplasien (NEN) mit bildgebenden und biochemischen Verfahren", "en": "Evaluation of tumor progression in metastasised in neuroendocrine neoplasia (NEN) with biochemical and imaging techniques" }, "short": "Registerstudie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-06-10T02:00:00+02:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2018-06-06T11:25:43+02:00", "program": null, "subprogram": "MEFOgraz", "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 65139, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-16", "ethics_committee": null, "edudract_number": null, "persons": [ "5380-65139-10" ] }, { "id": 5000, "title": { "de": "Veränderungen im intestinalen Mikrobiom als prädiktiver Marker für einen steroid-refraktären Krankheitsverlauf bei Colitis ulzerosa", "en": "Study investigating if specific fecal microbiota alterations can predict a refractory disease course to standard steroid therapy in patients with active ulcerative colitis.\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-07-01T02:00:00+02:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2017-07-06T14:47:36+02:00", "program": null, "subprogram": "ÖGGH Wissenschaftspreis", "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 53167, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 203 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5000-53167-10" ] }, { "id": 7215, "title": { "de": "Die Bedeutung von \"Glial Fibrillary Acidic Pretein\" im Plasma als diagnostischer und prognostischer Marker der Hirnalterung und der Alzheimer Krankheit", "en": "The Role of Plasma Glial Fibrillary Acidic Protein as a diagnostic and prognostic marker in brain aging and Alzheimer´s disease" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2022-10-13T14:04:13+02:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 57435, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2269 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7215-57435-10", "7215-73547-11" ] }, { "id": 8562, "title": { "de": "Pilotprojekt Telemedizin in der klinisch-forensischen Untersuchung", "en": "-" }, "short": "Telemedizin_klin-foren_Untersuchungen", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-07-01T02:00:00+02:00", "begin_effective": "2024-06-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-12-12T14:49:41+01:00", "program": null, "subprogram": null, "organization": 14019, "category": 10, "type": 10, "partner_function": 4, "manager": 115441, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8562-115441-10" ] }, { "id": 5241, "title": { "de": "Eine prospektive Studie zur Testung einer neuen Methode zur Bestimmung der minimalen Resterkrankung bei akuter myeloischer Leukämie", "en": "A prospective study to test a novel method for detection of minimal residual disease in acute myeloid leukemia " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-03-01T01:00:00+01:00", "begin_effective": "2018-03-01T01:00:00+01:00", "end_planned": "2019-02-28T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2018-02-08T13:51:42+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51911, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5241-51911-10" ] }, { "id": 8144, "title": { "de": "Metabolische Signaturen von T-Zell-Untergruppen als neue diagnostische oder therapeutische Angriffspunkte bei Kollagenose-assoziierten interstitiellen Lungenerkrankungen", "en": "Metabolic signatures of T cell subsets as novel diagnostic or therapeutic\r\ntargets in connective tissue disease-associated interstitial lung disease" }, "short": "T cell metabolism in CTD-ILD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-04-23T17:42:43+02:00", "program": null, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 3, "manager": 95212, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8144-78952-11", "8144-95212-10", "8144-107391-11" ] }, { "id": 6916, "title": { "de": "Korrelation von Tumorgröße und -biologie mit der Freisetzung von ctDNA bei Darmkrebs im Frühstadium", "en": "Correlation of tumor size and -biologie with ctDNA release in early colorectal cancer" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-01-01T01:00:00+01:00", "begin_effective": "2022-02-01T01:00:00+01:00", "end_planned": "2023-01-01T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2022-02-10T13:46:10+01:00", "program": null, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 4, "manager": 50899, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-36", "ethics_committee": null, "edudract_number": null, "persons": [ "6916-50899-10" ] }, { "id": 8151, "title": { "de": "Das intestinale Mikrobiom eines orthotopen und eines ektopen Hepatoblastom Mausmodelles", "en": "The Intestinal Microbiome in an Orthotopic and Ectopic Tumor Murine Model of Hepatoblastoma" }, "short": "Microbiome in Hepatoblastoma Mouse Model", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-04-24T15:59:17+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 1, "manager": 90375, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8151-50778-12", "8151-90375-10", "8151-97866-12" ] } ] }