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GET /v1/research/project/?format=api&offset=400&ordering=end_effective
{ "count": 2244, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=420&ordering=end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=380&ordering=end_effective", "results": [ { "id": 1732, "title": { "de": "Zerebrale und peripher-muskuläre Gewebssättigung unmittelbar nach der Geburt [Postpartale zerebrale und periphere Oxygenierung bei reifen Neugeborenen und Frühgeborenen]", "en": "Transition after birth: cerebral and peripheral muscle oxygenation in term and preterm neonates" }, "short": "Oxygenierung", "url": null, "abstract": { "de": "Mit Nah-Infrarot Spektroskopie (NIRS) kann die Oxygenierung in verschiedenen Gewebsregionen gemessen werden. Zahlreiche Studien bei reifen Neugeborenen und Frühgeborenen wurden bereits durchgeführt, wobei es jedoch noch keine Daten der zerebralen und peripher-muskulären Oxygenierung unmittelbar nach der Geburt gibt. \r\nZiel der vorliegenden Studie ist es daher, die zerebrale und peripher-muskuläre Oxygenierung unmittelbar nach der Geburt mit NIRS zu messen und zu analysieren. Sollte eine Atemunterstützung mit Maske notwendig sein, wird der Einfluss von \"continuous positive airway pressure\" (CPAP) oder \"positive pressure ventilation\" (PPV) analysiert. Das Studiendesign ist prospektiv beobachtend.\r\nNIRS wird kombiniert mit nicht-invasivem Monitoring der arteriellen Sauerstoffsättigung, der Herzfrequenz, der Hämoglobinkonzentration, des Blutdrucks, mit einer Videodokumentation und -bei Atemunterstützung mit CPAP oder PPV- mit einem Atemfunktionsmonitoring.", "en": "Mit Nah-Infrarot Spektroskopie (NIRS) kann die Oxygenierung in verschiedenen Gewebsregionen gemessen werden. Zahlreiche Studien bei reifen Neugeborenen und Frühgeborenen wurden bereits durchgeführt, wobei es jedoch noch keine Daten der zerebralen und peripher-muskulären Oxygenierung unmittelbar nach der Geburt gibt. \r\nZiel der vorliegenden Studie ist es daher, die zerebrale und peripher-muskuläre Oxygenierung unmittelbar nach der Geburt mit NIRS zu messen und zu analysieren. Sollte eine Atemunterstützung mit Maske notwendig sein, wird der Einfluss von \"continuous positive airway pressure\" (CPAP) oder \"positive pressure ventilation\" (PPV) analysiert. Das Studiendesign ist prospektiv beobachtend.\r\nNIRS wird kombiniert mit nicht-invasivem Monitoring der arteriellen Sauerstoffsättigung, der Herzfrequenz, der Hämoglobinkonzentration, des Blutdrucks, mit einer Videodokumentation und -bei Atemunterstützung mit CPAP oder PPV- mit einem Atemfunktionsmonitoring." }, "begin_planned": "2009-04-01T02:00:00+02:00", "begin_effective": "2009-04-01T02:00:00+02:00", "end_planned": "2011-03-31T02:00:00+02:00", "end_effective": "2012-02-28T01:00:00+01:00", "assignment": "2009-01-19T12:54:11+01:00", "program": 79, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 50907, "contact": 50907, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1732-50907-10" ] }, { "id": 1821, "title": { "de": "Nano-Health: Nano-Plaque-Extension", "en": "Nano-Health: Nano-Plaque-Extension" }, "short": "Nano-Plaque-Extension", "url": null, "abstract": { "de": "The increasing incidence of cancer and of degenerative diseases, the latter increasingly in relatively young patientes, call for a new healthcare model that is more proactive, i.e. that detects disease pre-symptomatically when it is more amenable to treatment, more personalised, i.e. based on the growing knowledge about the molecular mechanisms underlying disease, less traumatic and more targeted, i.e. that non-invasively or minimally invasively and specifically treats the affected tissue or organ(s) and allows more informed interventions, i.e. That enables the progress of therapy and relapse to be followed in as close to real time as possible.\r\nThe extended project will build on the achievements of NANO-HEALTH made to date. Within the first two years an NP platform based on 4 different types of NPs was elaborated and optimised for drug delivery and imaging. All NPs were characterised in detail by physico-chemical and chemical methods. Starting from this platform, the most promising NPs were optimised for oral drug delivery, for a depot formulation of Vasoactive Intestinal Peptide (VIP), for contrast media using MRI and Spect/PET and to trace stem cells in vivo and for the early detection of atherosclerotic plaque. Several proof-of-concept studies were performed from the end of year 2 up to now (3 years and 3 months).\r\n\r\nThe prolongation of NANO-HEALTH year 5 to 7 will build on the work done to date to develop new NM-based solutions for targeted drug delivery and imaging. The following topics will be pursued:\r\n*Further development of thiomers for oral and topical (depot)delivery of active substances\r\n*(Based on the successful results obtained so far) large scale production processes for nano-thiomers and PLA-HSA-based NPs\r\n*Development of targeted imaging for cancer using MRI\r\n*Stem cell tracking in vivo\r\n*Atherosclerotic plaque detection\r\n*Chronic nanotoxicity", "en": "The increasing incidence of cancer and of degenerative diseases, the latter increasingly in relatively young patientes, call for a new healthcare model that is more proactive, i.e. that detects disease pre-symptomatically when it is more amenable to treatment, more personalised, i.e. based on the growing knowledge about the molecular mechanisms underlying disease, less traumatic and more targeted, i.e. that non-invasively or minimally invasively and specifically treats the affected tissue or organ(s) and allows more informed interventions, i.e. That enables the progress of therapy and relapse to be followed in as close to real time as possible.\r\nThe extended project will build on the achievements of NANO-HEALTH made to date. Within the first two years an NP platform based on 4 different types of NPs was elaborated and optimised for drug delivery and imaging. All NPs were characterised in detail by physico-chemical and chemical methods. Starting from this platform, the most promising NPs were optimised for oral drug delivery, for a depot formulation of Vasoactive Intestinal Peptide (VIP), for contrast media using MRI and Spect/PET and to trace stem cells in vivo and for the early detection of atherosclerotic plaque. Several proof-of-concept studies were performed from the end of year 2 up to now (3 years and 3 months).\r\n\r\nThe prolongation of NANO-HEALTH year 5 to 7 will build on the work done to date to develop new NM-based solutions for targeted drug delivery and imaging. The following topics will be pursued:\r\n*Further development of thiomers for oral and topical (depot)delivery of active substances\r\n*(Based on the successful results obtained so far) large scale production processes for nano-thiomers and PLA-HSA-based NPs\r\n*Development of targeted imaging for cancer using MRI\r\n*Stem cell tracking in vivo\r\n*Atherosclerotic plaque detection\r\n*Chronic nanotoxicity" }, "begin_planned": "2009-03-01T01:00:00+01:00", "begin_effective": "2009-03-01T01:00:00+01:00", "end_planned": "2012-01-28T01:00:00+01:00", "end_effective": "2012-02-28T01:00:00+01:00", "assignment": "2009-05-18T13:05:25+02:00", "program": null, "subprogram": "Nano-Health Verlängerung", "organization": 14028, "category": 10, "type": 10, "partner_function": 2, "manager": 52854, "contact": 52854, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1821-52854-10" ] }, { "id": 1991, "title": { "de": "Proteomic characterization of mitochondrial ion channels", "en": "Proteomic characterization of mitochondrial ion channels" }, "short": "mitochondrial ion channels", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2012-03-13T01:00:00+01:00", "end_effective": "2012-03-13T01:00:00+01:00", "assignment": "2009-11-25T16:00:48+01:00", "program": 69, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "J2968-B19", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2520, "title": { "de": "CORA-BGF 2011 Untersuchung der positiven Auswirkungen erhöhter Gravitationsbelastung auf die Kreislaufbelastbarkeit", "en": "CORA-BGF 2011 Untersuchung der positiven Auswirkungen erhöhter Gravitationsbelastung auf die Kreislaufbelastbarkeit" }, "short": "CORA GBF", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2012-03-30T02:00:00+02:00", "end_effective": "2012-03-30T02:00:00+02:00", "assignment": "2011-07-05T14:52:27+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 57932, "contact": 57932, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2520-57932-10" ] }, { "id": 2553, "title": { "de": "Der Einfluss von Dexamethason auf rheumatoide Synoviozyten untersucht anhand einer Gen Chip Transkriptionsanalyse", "en": "The Influence of Dexamethasone on Rheumatoid Fibroblast-Like Synoviocytes based on a Gene CHip Transcription Analysis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-01T02:00:00+02:00", "begin_effective": "2011-08-09T02:00:00+02:00", "end_planned": "2011-10-31T01:00:00+01:00", "end_effective": "2012-03-30T02:00:00+02:00", "assignment": "2011-08-10T10:28:02+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2438, "title": { "de": "Genvarianten in den RAD51-, XRCC2-, XRCC3-, XPD- und XPG-Genen als Prädiktionsfaktoren für Metastasierung bei PatientInnen mit Weichteilsarkomen", "en": "Genetic variants in the RAD51, XRCC2, XRCC3, XPD and XPG genes as predictors of outcome in soft tissue sarcoma patients" }, "short": "SOFT TISSUE SARCOMA PATIENTS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-12-01T01:00:00+01:00", "begin_effective": "2011-04-01T02:00:00+02:00", "end_planned": "2011-12-01T01:00:00+01:00", "end_effective": "2012-03-30T02:00:00+02:00", "assignment": "2011-03-03T12:10:08+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 69234, "contact": 69234, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2438-69234-10", "2438-58814-12" ] }, { "id": 2567, "title": { "de": "Die Wirkung eines Konzentrates multipotenter Knochenmarkszellen auf die Knochenregeneration und die Osseointegration von Zahnimplantaten nach Sinusbodenelevation", "en": "Die Wirkung eines Konzentrates multipotenter Knochenmarkszellen auf die Knochenregeneration und die Osseointegration von Zahnimplantaten nach Sinusbodenelevation" }, "short": "Multipotente Knochenmarkszellen", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-03-01T01:00:00+01:00", "begin_effective": "2011-09-01T02:00:00+02:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2012-03-30T02:00:00+02:00", "assignment": "2011-09-05T17:35:08+02:00", "program": null, "subprogram": null, "organization": 14057, "category": 10, "type": 10, "partner_function": 4, "manager": 50792, "contact": 50792, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2567-50792-10" ] }, { "id": 2197, "title": { "de": "Aufbau eines osteuropäisches Implantationszentrum mit angeschlossenen Rehabilitations- und Trainingszentrum", "en": "Development of an Eastern European implantation center with adjacent Rehabilitation and Trainings center" }, "short": "Osteuropäisches_Implantationszentrum", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-04-01T02:00:00+02:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2011-02-01T01:00:00+01:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2010-05-07T10:52:01+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2390, "title": { "de": "Suche genetischer Faktoren in Neurotrophinen beim primären Offenwinkelglaukom", "en": "Candidate Gene Analysis in Neurotrophins in Primary Open Angle Glaucoma using Haplotype Tagging Single Nucleotide Polymorphisms" }, "short": "CANDIDATE GENE ANALYSIS_GLAUCOMA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-02-01T01:00:00+01:00", "begin_effective": "2011-04-01T02:00:00+02:00", "end_planned": "2013-01-31T01:00:00+01:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2011-02-04T09:28:08+01:00", "program": 79, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 981, "title": { "de": "SFB LIPOTOXICITY - Part 07: Myeloperoxidase-mediated lipotoxicity in the central nervous system", "en": "SFB LIPOTOXICITY" }, "short": "SFB LIPOTOXICITY", "url": null, "abstract": { "de": "Das Ziel des SFB-LIPOTOX ist die Zusammenführung relevanter Forschungsgruppen um gemeinsam ein zentrales Thema zu bearbeiten, Lipotoxizität. Unter Lipotoxizität versteht man die fehlgesteuerte Aufnahme bzw. Produktion von Fettsäuren und Lipiden, die zur Bildung (lipo)toxischer Substanzen führen, die Dysfunktion von Zellen und Geweben bewirken und im Zelltod enden können. Wir wollen jene metabolischen Vorgänge und molekularen Mechanismen untersuchen, die durch lipotoxische Effektoren ausgelöst werden und die pathologische Basis prävalenter Erkrankungen, wie z.B. dem Metabolischen Syndrom, Typ-2 Diabetes und Atherosklerose darstellen. Dieses hochgesteckte Ziel ist nur durch eine gemeinsame Anstrengung innerhalb eines dynamischen und interaktiven Konsortiums, die weit über die Möglichkeiten innerhalb von Einzelprojektförderungen hinausgeht, zu erreichen. Durch Einsatz aktueller genomischer, proteomischer und lipidomischer Methoden sollen neue lipotoxische Stoffwechselwege entdeckt werden. Durch Einsatz mutanter Maus- und Hefemodelle werden jene molekulare Mechanismen untersucht, durch die zelluläre Dysfunktion und Zelltod bewirkt werden. Die gewonnenen Erkenntnisse können somit einen wichtigen Beitrag zur Auffindung neuartiger Diagnose- und Behandlungsmethoden leisten.", "en": "Das Ziel des SFB-LIPOTOX ist die Zusammenführung relevanter Forschungsgruppen um gemeinsam ein zentrales Thema zu bearbeiten, Lipotoxizität. Unter Lipotoxizität versteht man die fehlgesteuerte Aufnahme bzw. Produktion von Fettsäuren und Lipiden, die zur Bildung (lipo)toxischer Substanzen führen, die Dysfunktion von Zellen und Geweben bewirken und im Zelltod enden können. Wir wollen jene metabolischen Vorgänge und molekularen Mechanismen untersuchen, die durch lipotoxische Effektoren ausgelöst werden und die pathologische Basis prävalenter Erkrankungen, wie z.B. dem Metabolischen Syndrom, Typ-2 Diabetes und Atherosklerose darstellen. Dieses hochgesteckte Ziel ist nur durch eine gemeinsame Anstrengung innerhalb eines dynamischen und interaktiven Konsortiums, die weit über die Möglichkeiten innerhalb von Einzelprojektförderungen hinausgeht, zu erreichen. Durch Einsatz aktueller genomischer, proteomischer und lipidomischer Methoden sollen neue lipotoxische Stoffwechselwege entdeckt werden. Durch Einsatz mutanter Maus- und Hefemodelle werden jene molekulare Mechanismen untersucht, durch die zelluläre Dysfunktion und Zelltod bewirkt werden. Die gewonnenen Erkenntnisse können somit einen wichtigen Beitrag zur Auffindung neuartiger Diagnose- und Behandlungsmethoden leisten." }, "begin_planned": "2007-03-01T01:00:00+01:00", "begin_effective": "2007-03-01T01:00:00+01:00", "end_planned": "2011-02-28T01:00:00+01:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2006-12-27T15:02:44+01:00", "program": 67, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51705, "contact": 51833, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "F30", "ethics_committee": null, "edudract_number": null, "persons": [ "981-51705-10" ] }, { "id": 2340, "title": { "de": "Die Bedeutung des gluconeogenetischen Enzyms Phosphoenolpyruvat Carboxykinase (PEPCK) für das Tumorwachstum", "en": "The role of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) in cancer growth" }, "short": "PEPCK", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-09-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2010-11-17T10:58:29+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 57557, "contact": 57557, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2340-57557-10" ] }, { "id": 2198, "title": { "de": "Kommunikation als Screeninginstrument", "en": "Kommunikation als Screeninginstrument" }, "short": "KOMMUNIK_SCREENING", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-10-01T02:00:00+02:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2011-05-31T02:00:00+02:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2010-05-07T16:16:27+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": 54332, "contact": 54332, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 70 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2198-54332-10" ] }, { "id": 2758, "title": { "de": "Body Composition and Performance: Relatives Körpergewicht österreichischer Athleten", "en": "Body Composition and Performance" }, "short": "Body Composition", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-01-01T01:00:00+01:00", "begin_effective": "2012-01-01T01:00:00+01:00", "end_planned": "2012-03-31T02:00:00+02:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2012-01-19T16:37:18+01:00", "program": 90, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1326 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1145, "title": { "de": "Rett Disorder: The Pre-Regression Period", "en": "Rett Disorder: The Pre-Regression Period" }, "short": "RETTDISORDER_FWF07", "url": null, "abstract": { "de": "The main focus of this project is on the motor, behavioural and communicative development in girls with Rett disorder from the age of 6 months to the onset of regression (12 to 18 months). The new results will be discussed in the light of continuity or discontinuity with the findings during the first 6 months of life. In addition, the results of the pre-regression period will be assessed in view of a possible association between genotypes and the severity of phenotypes.", "en": "The main focus of this project is on the motor, behavioural and communicative development in girls with Rett disorder from the age of 6 months to the onset of regression (12 to 18 months). The new results will be discussed in the light of continuity or discontinuity with the findings during the first 6 months of life. In addition, the results of the pre-regression period will be assessed in view of a possible association between genotypes and the severity of phenotypes." }, "begin_planned": "2007-04-01T02:00:00+02:00", "begin_effective": "2007-04-01T02:00:00+02:00", "end_planned": "2010-03-31T02:00:00+02:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2007-03-02T09:43:48+01:00", "program": 72, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P19581", "ethics_committee": null, "edudract_number": null, "persons": [ "1145-58883-12" ] }, { "id": 1714, "title": { "de": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling", "en": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling" }, "short": "GOLD3_BIRNER_GRUENBERGER", "url": null, "abstract": { "de": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.", "en": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis." }, "begin_planned": "2008-12-01T01:00:00+01:00", "begin_effective": "2009-02-01T01:00:00+01:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2009-01-14T12:15:11+01:00", "program": 73, "subprogram": null, "organization": 28394, "category": 10, "type": 10, "partner_function": 2, "manager": 58794, "contact": 58794, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1714-58794-10" ] }, { "id": 2104, "title": { "de": "Refining the basophil activation test (BAT) for the diagnosis of Hymenoptera venom allergy", "en": "Refining the basophil activation test (BAT) for the diagnosis of Hymenoptera venom allergy" }, "short": "BAT_09", "url": null, "abstract": { "de": "Weiterentwicklung des Basophilen-Aktivierungstests (BAT) für die Diagnostik der Insektengiftallergie\r\n\r\nZur Routinediagnostik einer Insektengiftallergie gehören Anamnese, Hauttests und die Bestimmung spezifischer IgE Antikörper im Serum. Leider führen diese Verfahren manchmal zu inkonkulsiven Ergebnissen. In den letzten Jahren hat sich der Basophilenaktivierungstest (BAT) als nützliche zusätzliche Methode bewährt. Ein Nachteil des BAT ist jedoch, dass durch den Grad der Zellaktivierung im Test sich kein Rückschluss auf den Schweregrad der allergischen Reaktion ziehen lässt. Ferner sind Daten verschiedener Labors kaum vergleichbar, da es kein standardisiertes Protokoll gibt. Um nun die Möglichkeiten der Allergiediagnostik zu optimieren und für den betroffen Patienten die bestmögliche Versorgung sicherzustellen ist es unerlässlich, auf diesem Gebiet nach weiteren neuen Ansatzpunkten zu suchen. Ziel des Projektes ist es daher einen auf der Expression verschiedener neuer Oberflächenmarker basierenden Basophilenaktivierungstest für die Diagnostik der Insektengiftallergie zu entwickeln.\r\n", "en": null }, "begin_planned": "2010-05-01T02:00:00+02:00", "begin_effective": "2010-05-01T02:00:00+02:00", "end_planned": "2012-04-30T02:00:00+02:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2010-02-10T17:29:56+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 87717, "contact": 87717, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1161 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2104-87717-10" ] }, { "id": 2780, "title": { "de": "Gelotophobie - Die Angst vor dem Lachen anderer - Studie zur Erforschung der zu Grunde liegenden emotionalen Prozesse in spontaner Interaktion.", "en": "Gelotophobia - A biopsychological approach" }, "short": "Gelotophobie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-02-01T01:00:00+01:00", "begin_effective": "2012-02-01T01:00:00+01:00", "end_planned": "2012-04-30T02:00:00+02:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2012-02-06T18:26:26+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 3, "manager": 64295, "contact": 64295, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2780-64295-10" ] }, { "id": 1735, "title": { "de": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 8: Lipid droplet-associated proteins regulating lipid storage and release in macrophages and foam cells", "en": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 8: Lipid droplet-associated proteins regulating lipid storage and release in macrophages and foam cells" }, "short": "GOLD3_KRATKY", "url": null, "abstract": { "de": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.", "en": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis." }, "begin_planned": "2008-12-01T01:00:00+01:00", "begin_effective": "2009-02-01T01:00:00+01:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2009-01-22T11:56:26+01:00", "program": 73, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51904, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1735-51904-10", "1735-58794-11" ] }, { "id": 2480, "title": { "de": "FET FlagShip: Information Technology Future of Medicine", "en": "FET FlagShip: Information Technology Future of Medicine" }, "short": "IT FoM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-01T02:00:00+02:00", "begin_effective": "2011-05-01T02:00:00+02:00", "end_planned": "2012-06-01T02:00:00+02:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2011-05-19T10:22:48+02:00", "program": 24, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": 51663, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": " 285609", "ethics_committee": null, "edudract_number": null, "persons": [ "2480-51663-10" ] }, { "id": 1822, "title": { "de": "Mechanisms of restoration of ß-cell function in relation to adipoinsular and enteroinsular axes after gastric bypass surgery in severly obese patients with type 2 diabetes - double-centre, prospective, controlled, longitudinal open study - short: Restoration of ß-cell function after gastric bypass", "en": "Mechanisms of restoration of ß-cell function in relation to adipoinsular and enteroinsular axes after gastric bypass surgery in severly obese patients with type 2 diabetes - double-centre, prospective, controlled, longitudinal open study - short: Restoration of ß-cell function after gastric bypass" }, "short": "Restoration of ß-cell function", "url": null, "abstract": { "de": "The presented project aims to: \r\n1) compare changes in â-cell function following gastric bypass in patients with short- and long-term history of type 2 diabetes (T2DM), \r\n2) evaluate the â-cell insulin response to oral and intravenous glucose load early and late after gastric bypass surgery,\r\n3) relate the early and long-term changes in â-cell function after gastric bypass to changes in parameters of adipoinsular and enteroinsular axes in patients with and without T2DM and \r\n4) compare the changes of adipoinsular and enteroinsular axes after weight loss achieved after gastric bypass with BMI-matched controls without bariatric surgery.", "en": "The presented project aims to: \r\n1) compare changes in â-cell function following gastric bypass in patients with short- and long-term history of type 2 diabetes (T2DM), \r\n2) evaluate the â-cell insulin response to oral and intravenous glucose load early and late after gastric bypass surgery,\r\n3) relate the early and long-term changes in â-cell function after gastric bypass to changes in parameters of adipoinsular and enteroinsular axes in patients with and without T2DM and \r\n4) compare the changes of adipoinsular and enteroinsular axes after weight loss achieved after gastric bypass with BMI-matched controls without bariatric surgery." }, "begin_planned": "2009-07-01T02:00:00+02:00", "begin_effective": "2009-07-01T02:00:00+02:00", "end_planned": "2011-06-30T02:00:00+02:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2009-05-18T17:08:39+02:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": 51831, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 431 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1822-51831-10" ] } ] }