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GET /v1/research/project/?format=api&offset=380&ordering=end_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=400&ordering=end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=360&ordering=end_effective", "results": [ { "id": 825, "title": { "de": "MPO-modifiziertes High-Density Lipoprotein und Rezeptoren", "en": "MPO-modified high-density lipoprotein and receptors" }, "short": "MPO-mod. HD LDL", "url": null, "abstract": { "de": "The vascular endothelium is a wide spread organ responsible for the regulation of hemodynamics, angiogenic vascular remodeling, metabolic, synthetic, antiinflammatory, and antithrombogenic processes. Diminished nitric oxide (NO) availability has been linked to vascular disease and a heightened state of inflammation is characterized, in part, by an increase in vascular myeloperoxidase and proteins in vivo modified by its principal oxidant, hypochlourous acid/hypochlorous acid/hypochlorite (HOCI/OCI). Modification of high-density lipoprotein (HDL) by HOCI generates a proatherogenic and proinflammatory lipoprotein particle. HOCI-HDL, present in human lesions material and on endothelial cells, attenuates the expression and activity of vasuloprotective endothelial NO synthase (eNOS). Therefore, one part of this application is to clarify the mechanisms that governs interaction of HODI-HDL and its lipid (plasmalogen)-derived oxidant 2-chlorohexadecanal with eNOS, to focus whether caveolae-located proteins are involved, to profile alterations in endothelial gene expression patterns, and to investigate endothelium-dependent vascular relaxation in aortic rings and perfused vessels. As endothelial dysfunction may be induced by receptor-ligand interaction, the other part of this application will focus on interaction of HOCI-HDL with candidate receptors mediating (patho)physiologically relevant cellualar responses, i.e. activation of transcription factors, kinases and production of cytokines, leadng to the perpetuation of the inflammatory response and endothelial dysfunction. To answer these questions cell lines overexpressing candidate receptors will be used before adapting the cellular signaling cascade patterns to a specific endothelial cell line. We propose that myeloperoxidase-modified HDL- a unique and clinically significant marker for atherosclerosis - mediates endothelial dysfunction by specific receptor-evoked intracellular signaling pathways. ", "en": "The vascular endothelium is a wide spread organ responsible for the regulation of hemodynamics, angiogenic vascular remodeling, metabolic, synthetic, antiinflammatory, and antithrombogenic processes. Diminished nitric oxide (NO) availability has been linked to vascular disease and a heightened state of inflammation is characterized, in part, by an increase in vascular myeloperoxidase and proteins in vivo modified by its principal oxidant, hypochlourous acid/hypochlorous acid/hypochlorite (HOCI/OCI). Modification of high-density lipoprotein (HDL) by HOCI generates a proatherogenic and proinflammatory lipoprotein particle. HOCI-HDL, present in human lesions material and on endothelial cells, attenuates the expression and activity of vasuloprotective endothelial NO synthase (eNOS). Therefore, one part of this application is to clarify the mechanisms that governs interaction of HODI-HDL and its lipid (plasmalogen)-derived oxidant 2-chlorohexadecanal with eNOS, to focus whether caveolae-located proteins are involved, to profile alterations in endothelial gene expression patterns, and to investigate endothelium-dependent vascular relaxation in aortic rings and perfused vessels. As endothelial dysfunction may be induced by receptor-ligand interaction, the other part of this application will focus on interaction of HOCI-HDL with candidate receptors mediating (patho)physiologically relevant cellualar responses, i.e. activation of transcription factors, kinases and production of cytokines, leadng to the perpetuation of the inflammatory response and endothelial dysfunction. To answer these questions cell lines overexpressing candidate receptors will be used before adapting the cellular signaling cascade patterns to a specific endothelial cell line. We propose that myeloperoxidase-modified HDL- a unique and clinically significant marker for atherosclerosis - mediates endothelial dysfunction by specific receptor-evoked intracellular signaling pathways. " }, "begin_planned": "2006-07-01T02:00:00+02:00", "begin_effective": "2006-12-16T01:00:00+01:00", "end_planned": "2009-06-30T02:00:00+02:00", "end_effective": "2011-12-15T01:00:00+01:00", "assignment": "2006-05-16T17:47:52+02:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51833, "contact": 51833, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P19074", "ethics_committee": null, "edudract_number": null, "persons": [ "825-51833-10" ] }, { "id": 2457, "title": { "de": "INTEROCEPTION AND ARTERIAL STIFFNESS", "en": "INTEROCEPTION AND ARTERIAL STIFFNESS" }, "short": "STRESS HYPOXIC CONDITIONS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-04-01T02:00:00+02:00", "begin_effective": "2011-03-28T02:00:00+02:00", "end_planned": "2011-12-30T01:00:00+01:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-03-29T11:56:04+02:00", "program": null, "subprogram": null, "organization": 29447, "category": 10, "type": 10, "partner_function": 4, "manager": 60040, "contact": 60040, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2457-60040-10" ] }, { "id": 2460, "title": { "de": "Etablierung organtypischer Zellkultur für Herzgewebe", "en": "Establishing of organotypic cell culture for heart tissue" }, "short": "ORGANOTYPIC CELL CULTURE HEART TISSUE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-03-01T01:00:00+01:00", "begin_effective": "2011-05-01T02:00:00+02:00", "end_planned": "2011-08-31T02:00:00+02:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-04-07T13:19:02+02:00", "program": null, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2451, "title": { "de": "Ein US28/GNA Fusionsprotein zur Induktion der Apoptose beim Melanom", "en": "A US28/GNA Fusion Protein to Induce Apoptosis in Melanoma " }, "short": "US28/GNA and Melanoma", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-03-01T01:00:00+01:00", "begin_effective": "2011-04-01T02:00:00+02:00", "end_planned": "2011-05-31T02:00:00+02:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-03-23T11:47:48+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 53662, "contact": 53662, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2451-53662-10" ] }, { "id": 2406, "title": { "de": "Adipokine Visfatin und Chemerin im Kindes- und Jugendalter", "en": "The adipokines visfatin and chemerin in childhood and adolescence" }, "short": "ADIPOKINE VISFATIN CHEMERIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-10-01T02:00:00+02:00", "begin_effective": "2011-03-01T01:00:00+01:00", "end_planned": "2011-10-01T02:00:00+02:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-02-15T12:46:08+01:00", "program": null, "subprogram": null, "organization": 14091, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1610, "title": { "de": "Vitamin D and new bone marker levels in breast cancer patients with and without bone metastases", "en": "Vitamin D and new bone marker levels in breast cancer patients with and without bone metastases" }, "short": "VIT_D_BONE_MARKER_LEVELS", "url": null, "abstract": { "de": "Brustkrebs (BrCa) ist die häufigste Form von Krebs bei Frauen. Das Skelettsystem ist ein bevorzugtes Ziel für Metastasen bei BrCa. Hoher Knochenumsatz erhöht das Risiko für Krankheitsprogression und Tod. Der im Knochenstoffwechsel etablierte Einfluss von Vitamin D3 könnte daher auch ein wichtiger Risikofaktor für Skelettmetastasen sein.\r\nVitamin D3 und Serummarker des Knochenstoffwechsels sollen aus einer großen retrospektiven Kohorte von BrCa-Patientinnen mit einem Pool von 5400 BrCa-Patientinnen an ausgewählten Patientinnen mit (n=1050) und ohne Knochenmetastasen in konsekutiven Serumproben ausgewertet werden. Diese Gruppen werden in Alter und Tumorstadium übereingestimmt und sowohl im Querschnitt als auch im Verlauf nach Knochenmetastasen untersucht. Wir erwarten aus dieser Auswertung neue Perspektiven für Vitamin D3 und Knochenstoffwechselmarker in Pathophysiologie, Diagnose und Verlauf von Knochenmetastasen bei Brustkrebspatientinnen.", "en": "Brustkrebs (BrCa) ist die häufigste Form von Krebs bei Frauen. Das Skelettsystem ist ein bevorzugtes Ziel für Metastasen bei BrCa. Hoher Knochenumsatz erhöht das Risiko für Krankheitsprogression und Tod. Der im Knochenstoffwechsel etablierte Einfluss von Vitamin D3 könnte daher auch ein wichtiger Risikofaktor für Skelettmetastasen sein.\r\nVitamin D3 und Serummarker des Knochenstoffwechsels sollen aus einer großen retrospektiven Kohorte von BrCa-Patientinnen mit einem Pool von 5400 BrCa-Patientinnen an ausgewählten Patientinnen mit (n=1050) und ohne Knochenmetastasen in konsekutiven Serumproben ausgewertet werden. Diese Gruppen werden in Alter und Tumorstadium übereingestimmt und sowohl im Querschnitt als auch im Verlauf nach Knochenmetastasen untersucht. Wir erwarten aus dieser Auswertung neue Perspektiven für Vitamin D3 und Knochenstoffwechselmarker in Pathophysiologie, Diagnose und Verlauf von Knochenmetastasen bei Brustkrebspatientinnen." }, "begin_planned": "2008-07-01T02:00:00+02:00", "begin_effective": "2008-07-01T02:00:00+02:00", "end_planned": "2009-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2008-08-22T12:07:22+02:00", "program": 79, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 51809, "contact": 51809, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1610-51809-10", "1610-51692-12", "1610-57544-12" ] }, { "id": 1901, "title": { "de": "Neurale Korrelate des Schriftspracherwerbs bei morphembasiertem Training bei Legasthenie gemessen anhand der funktionellen Magnetresonanztomographie", "en": "Neurale Korrelate des Schriftspracherwerbs bei morphembasiertem Training bei Legasthenie gemessen anhand der funktionellen Magnetresonanztomographie" }, "short": "Legasthenie ", "url": null, "abstract": { "de": "Die Lese- und Rechtschreibschwäche (Legasthenie) wird zunehmend als ernstzunehmendes Problem erkannt. Erscheinungsformen und Ursachen sind vielfältig und weitgehend ungeklärt. Die zum überwiegenden Teil durchschnittlich bis überdurchschnittlich intelligenten Kinder und Jugendlichen haben-teils organisch, teils psychosozial bedingt- spezifische Schwierigkeiten beim Lesen und Schreiben, wobei die Leistungen \"...unter dem Niveau liegen, das aufgrund des Alters, der allgemeinen Intelligenz und der Beschulung zu erwarten ist\" (Dilling et al. 1991). Wird die Lese-Rechtschreibschwäche nicht frühzeitig erkannt und behandelt, wirkt sich diese bald auch in anderen Wissensbereichen, in denen Lesen vorausgesetzt wird, negativ aus.\r\nIn dieser Studie sollen legasthene Kinder und Jugendliche zwischen 9 und 16 Jahren untersucht und behandelt werden. In einem Vortest wird untersucht, mit welchen psychologischen Funktionsstörungen die Lese- und Rechtschreibschwäche einhergeht. Die TeilnehmerInnen werden dann einer speziellen fMRT Untersuchung unterzogen. Anschließend wird die Gruppe nach einem 5-wöchigen Intensivtraining (mittels MORPHEUS: einem in der Steiermark entwickelten computergestützten Grundwortschatz-Segmentierungstraining, das auf jeden beliebigen Heim-PC installiert werden kann) erneut einer fMRT Untersuchung zugeführt. Eine zweite Warte- bzw. Kontrollgruppe erhält zunächst kein Rechtschreibtraining, wird aber ebenso zweimalig mittels fMRT untersucht. Dadurch lassen sich wesentliche Erkenntnisse über neurophysiologische Veränderungen als Folge des Trainings erwarten.", "en": "Die Lese- und Rechtschreibschwäche (Legasthenie) wird zunehmend als ernstzunehmendes Problem erkannt. Erscheinungsformen und Ursachen sind vielfältig und weitgehend ungeklärt. Die zum überwiegenden Teil durchschnittlich bis überdurchschnittlich intelligenten Kinder und Jugendlichen haben-teils organisch, teils psychosozial bedingt- spezifische Schwierigkeiten beim Lesen und Schreiben, wobei die Leistungen \"...unter dem Niveau liegen, das aufgrund des Alters, der allgemeinen Intelligenz und der Beschulung zu erwarten ist\" (Dilling et al. 1991). Wird die Lese-Rechtschreibschwäche nicht frühzeitig erkannt und behandelt, wirkt sich diese bald auch in anderen Wissensbereichen, in denen Lesen vorausgesetzt wird, negativ aus.\r\nIn dieser Studie sollen legasthene Kinder und Jugendliche zwischen 9 und 16 Jahren untersucht und behandelt werden. In einem Vortest wird untersucht, mit welchen psychologischen Funktionsstörungen die Lese- und Rechtschreibschwäche einhergeht. Die TeilnehmerInnen werden dann einer speziellen fMRT Untersuchung unterzogen. Anschließend wird die Gruppe nach einem 5-wöchigen Intensivtraining (mittels MORPHEUS: einem in der Steiermark entwickelten computergestützten Grundwortschatz-Segmentierungstraining, das auf jeden beliebigen Heim-PC installiert werden kann) erneut einer fMRT Untersuchung zugeführt. Eine zweite Warte- bzw. Kontrollgruppe erhält zunächst kein Rechtschreibtraining, wird aber ebenso zweimalig mittels fMRT untersucht. Dadurch lassen sich wesentliche Erkenntnisse über neurophysiologische Veränderungen als Folge des Trainings erwarten." }, "begin_planned": "2009-09-01T02:00:00+02:00", "begin_effective": "2009-09-01T02:00:00+02:00", "end_planned": "2011-08-31T02:00:00+02:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2009-08-26T15:51:25+02:00", "program": null, "subprogram": "Land Steiermark. Projektantrag über 5.000,- euro", "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 50173, "contact": 50173, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1901-50173-10" ] }, { "id": 1510, "title": { "de": "EuroSTEC: Soft tissue engineering for congenital birth defects in children: from \"biomatrix - cell interaction - model system\" to clinical trials", "en": "EuroSTEC: Soft tissue engineering for congenital birth defects in children: from \"biomatrix - cell interaction - model system\" to clinical trials" }, "short": "IMPPACT", "url": null, "abstract": { "de": "IMPPACT will develop an intervention planning and monitoring application for Radiofrequency Ablation (RFA) of malignant liver tumours. RFA is a minimally invasive form to treat cancer without open surgery, by placing a needle inside the malignancy and destroying it through intensive heating. Though the advantages of this approach ale obvious, the intervention is currently hard to plan, almost impossible to monitor or assess, and therefore is not the first choice for treatment. IMPPACT will develop a physiological model of the liver and simulate the intervention's result, accounting for patient specific physiological factors. Gaps in the understanding of particular aspects of the RFA treatment will be closed by multi-scale studies on cells and animals. New findings will be evaluated microscopically and transformed into macroscopic equations. The long-established bio-heat equation will be extended to incorporate multiple scales. Validation will be performed at multiple levels. Images from ongoing patient treatment will be used to cross check validity for human physiology. Final validation will be performed at macroscopic level through visual comparison of simulation and treatment results gathered in animal studies and during patient treatment. This extensive validation together with a user-centered software design approach will guarantee suitability of the solution for clinical practice. The consortium consists of two Hospitals, three Universities, one Research Institute and one industrial SME. The final project deliverables will be the patient specific intervention planning system and an augmented reality training simulator for the RFA intervention.", "en": "IMPPACT will develop an intervention planning and monitoring application for Radiofrequency Ablation (RFA) of malignant liver tumours. RFA is a minimally invasive form to treat cancer without open surgery, by placing a needle inside the malignancy and destroying it through intensive heating. Though the advantages of this approach ale obvious, the intervention is currently hard to plan, almost impossible to monitor or assess, and therefore is not the first choice for treatment. IMPPACT will develop a physiological model of the liver and simulate the intervention's result, accounting for patient specific physiological factors. Gaps in the understanding of particular aspects of the RFA treatment will be closed by multi-scale studies on cells and animals. New findings will be evaluated microscopically and transformed into macroscopic equations. The long-established bio-heat equation will be extended to incorporate multiple scales. Validation will be performed at multiple levels. Images from ongoing patient treatment will be used to cross check validity for human physiology. Final validation will be performed at macroscopic level through visual comparison of simulation and treatment results gathered in animal studies and during patient treatment. This extensive validation together with a user-centered software design approach will guarantee suitability of the solution for clinical practice. The consortium consists of two Hospitals, three Universities, one Research Institute and one industrial SME. The final project deliverables will be the patient specific intervention planning system and an augmented reality training simulator for the RFA intervention." }, "begin_planned": "2008-06-01T02:00:00+02:00", "begin_effective": "2008-09-01T02:00:00+02:00", "end_planned": "2011-05-31T02:00:00+02:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2008-04-09T17:00:52+02:00", "program": 24, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 2, "manager": 50874, "contact": 50874, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1510-50874-10", "1510-62118-12", "1510-51955-12", "1510-51983-12" ] }, { "id": 2092, "title": { "de": "Analysis of germline polymorphisms in the VEGF/VEGFR pathway to predict colorectal cancer outcome", "en": "Analysis of germline polymorphisms in the VEGF/VEGFR pathway to predict colorectal cancer outcome" }, "short": "GERMLINE POLYMORPH VEGF/VEGFR", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2010-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T11:47:57+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 59304, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2092-59304-10", "2092-58814-12" ] }, { "id": 2093, "title": { "de": "Isolation of Side Population Cells in Human Soft Tissue Sarcomas", "en": "Isolation of Side Population Cells in Human Soft Tissue Sarcomas" }, "short": "ISOLATION OF SIDE POP CELLS ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T12:52:51+01:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50696, "contact": 50696, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2093-50696-10" ] }, { "id": 2130, "title": { "de": "Kinder erzählen: Text- und Erzählkompetenz im Vorschulalter: eine Voraussetzung für den schulischen Erfolg.", "en": "Narratives in first language acquisition." }, "short": "TEXT- UND ERZÄHLKOMPETENZ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-03-01T01:00:00+01:00", "begin_effective": "2010-03-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-24T10:55:39+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 2, "manager": 58883, "contact": 58883, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2130-58883-10" ] }, { "id": 2341, "title": { "de": "Einzelzellanalyse in der forensischen Medizin", "en": "Single cell analysis in forensic medicine" }, "short": "Single cell analysis", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-05-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2011-04-30T02:00:00+02:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-11-17T11:21:30+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 54171, "contact": 54171, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2341-54171-10" ] }, { "id": 2498, "title": { "de": "Die Rolle von Metalloproteasen und Endothelin im ersten Schwangerschaftstrimester", "en": "The role of metalloproteinases and endothelin in the first trimester of pregnancy" }, "short": "METALLPROTEINASES_ENDOTHELIN_PREGNANCY", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2011-06-16T12:49:53+02:00", "program": null, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1771, "title": { "de": "Rett Disorder: The Pre-Regression Period", "en": "Rett Disorder: The Pre-Regression Period" }, "short": "RETT DISORDER", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2007-01-01T01:00:00+01:00", "begin_effective": "2007-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2009-03-30T17:24:34+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2023, "title": { "de": "Induction of immunological changes by endoluminal photodynamic therapy (PDT) for esophageal carcinoma", "en": "Induction of immunological changes by endoluminal photodynamic therapy (PDT) for esophageal carcinoma" }, "short": "PDT_ESOPHAGEAL_CARCINOMA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2009-12-18T12:29:42+01:00", "program": 79, "subprogram": null, "organization": 14077, "category": 10, "type": 10, "partner_function": 4, "manager": 51615, "contact": 51615, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2023-62056-12", "2023-51615-10", "2023-51618-12" ] }, { "id": 1868, "title": { "de": "Computer-based analysis of heart rate variability (HRV) during different methods of acupuncture", "en": "Computer-based analysis of heart rate variability (HRV) during different methods of acupuncture" }, "short": "HRV during acupuncture", "url": null, "abstract": { "de": "Die Herzratenvariabilität stellt die prozentuelle Änderung aufeinander folgender Kammerkomplexe im EKG dar. Der Parameter HRV wird durch das Blutdruckkontrollsystem, Einflüsse vom Hypothalamus und vor allem durch den vagalen Teil des Kreislaufzentrums im unteren Hirnstamm vermittelt. Eine computergestützte Analyse der HRV soll während unterschiedlicher Methoden der Akupunktur und anderer Stimulationsmethoden im gegenständlichen Projekt zum Einsatz kommen. Für die Untersuchungen soll ein Medilog AR 12 verwendet werden. Insgesamt sollen 80 Probanden (im Alter 20-50 Jahren) während unterschiedlicher Akupunktursitzungen (Nadel- und Laserakupunktur) untersucht werden. Dabei werden die folgenden Akupunkturpunkte verwendet: Neiguan (Pe.6), Shenmen (He.7) und Hegu (Di.4). Innerhalb dieses Projektes soll die HRV auch während Stimulationen des Punktes Yintang (Ex.1) näher untersucht werden. Das Projekt könnte dazu beitragen, die Beziehungen zwischen westlicher und östlicher Medizin zu vertiefen.", "en": "Die Herzratenvariabilität stellt die prozentuelle Änderung aufeinander folgender Kammerkomplexe im EKG dar. Der Parameter HRV wird durch das Blutdruckkontrollsystem, Einflüsse vom Hypothalamus und vor allem durch den vagalen Teil des Kreislaufzentrums im unteren Hirnstamm vermittelt. Eine computergestützte Analyse der HRV soll während unterschiedlicher Methoden der Akupunktur und anderer Stimulationsmethoden im gegenständlichen Projekt zum Einsatz kommen. Für die Untersuchungen soll ein Medilog AR 12 verwendet werden. Insgesamt sollen 80 Probanden (im Alter 20-50 Jahren) während unterschiedlicher Akupunktursitzungen (Nadel- und Laserakupunktur) untersucht werden. Dabei werden die folgenden Akupunkturpunkte verwendet: Neiguan (Pe.6), Shenmen (He.7) und Hegu (Di.4). Innerhalb dieses Projektes soll die HRV auch während Stimulationen des Punktes Yintang (Ex.1) näher untersucht werden. Das Projekt könnte dazu beitragen, die Beziehungen zwischen westlicher und östlicher Medizin zu vertiefen." }, "begin_planned": "2009-10-01T02:00:00+02:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-09-30T02:00:00+02:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2009-07-13T18:54:46+02:00", "program": 79, "subprogram": null, "organization": 14044, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1868-54121-12" ] }, { "id": 2097, "title": { "de": "Role of SPN in PP1-mediated RyR2 regulation and intracellular Ca2+ handling", "en": "Role of SPN in PP1-mediated RyR2 regulation and intracellular Ca2+ handling" }, "short": "ROLE OF SPN ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T12:56:38+01:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2033, "title": { "de": "Mit autologen Thrombozyten angereichertes körpereigenes Fibrin zur Förderung der Wundheilung bei chronischem Ulcus cruris venosum (kontrollierte prospektive randomisierte klinische Studie)", "en": "Mit autologen Thrombozyten angereichertes körpereigenes Fibrin zur Förderung der Wundheilung bei chronischem Ulcus cruris venosum (kontrollierte prospektive randomisierte klinische Studie)" }, "short": " Ulcus cruris venosum Studie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2008-10-01T02:00:00+02:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2009-09-30T02:00:00+02:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-01-12T17:36:20+01:00", "program": null, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": 51612, "contact": 51612, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2033-51612-10" ] }, { "id": 2043, "title": { "de": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action", "en": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action" }, "short": "ORPHAN RECEPTOR GPR55", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-01-20T12:45:29+01:00", "program": 92, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2788, "title": { "de": "Scanningbewegungen des Kopfes als Ausdruck des Schauverhaltens am gehenden Patienten im Low vision Bereich: Entwicklung der Analysemethode und Standardisierung", "en": "Headscanning in Mobility Testing" }, "short": "Headscanning in Mobility Testing", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-01T02:00:00+02:00", "begin_effective": "2011-05-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2012-02-14T15:16:48+01:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 938 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] } ] }