List projects.

Fields

id (integer)

Primary key.

Expansions

To activate relation expansion add the desired fields as a comma separated list to the expand query parameter like this:

?expand=<field>,<field>,<field>,...

The following relational fields can be expanded:

  • organization
  • category
  • type
  • partner_function
  • manager
  • contact
  • status
  • grant
  • research
  • event
  • study
  • language
  • program
  • funders

Filters

To filter for exact value matches:

?<fieldname>=<value>

Possible exact filters:

  • organization
  • category
  • manager
  • contact
  • status
  • grant
  • research
  • study
  • language
  • funders
  • program

For advanced filtering use lookups:

?<fieldname>__<lookup>=<value>

All fields with advanced lookups can also be used for exact value matches as described above.

Possible advanced lookups:

  • begin_planned: gt, gte, lt, lte
  • begin_effective: gt, gte, lt, lte
  • end_planned: gt, gte, lt, lte
  • end_effective: gt, gte, lt, lte
GET /v1/research/project/?format=api&offset=380&ordering=begin_planned
HTTP 200 OK
  Allow: GET, HEAD, OPTIONS
  Content-Type: application/json
  Vary: Accept
  
  {
    "count": 2244,
    "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=400&ordering=begin_planned",
    "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=360&ordering=begin_planned",
    "results": [
        {
            "id": 2482,
            "title": {
                "de": "Experience-oriented Sharing of Health Knowledge via Information and Communication Technology",
                "en": "Experience-oriented Sharing of Health Knowledge via Information and Communication Technology"
            },
            "short": "ESICT",
            "url": null,
            "abstract": {
                "de": "Die ESICT-Konsortium (Experience-oriented Sharing of health knowledge via Information and Communication Technology) wird von dem dänischen Strategic Research Council finanziert. ESICT konzentriert sich auf die wissenschaftliche Untersuchung und Entwicklung von Methoden und Technologien, welche Bürgern mittels eines innovativen Informationssystems über chronische Erkrankungen aufklärt, unter Verwendung  von Sprachtechnologien und medizinischen Wissensbasen. Das Ziel von ESICT ist die computergestützte Beantwortung von natürlichsprachigen Benutzeranfragen.",
                "en": "The ESICT consortium (Experience-oriented Sharing of health knowledge via Information and Communication Technology) is funded by the Danish Strategic Research Council. ESICT focuses on research in methods and development of technologies providing citizens with an innovative information system on chronic diseases based on language technology and formalized medical knowledge. The goal of ESICT is to allow users to ask questions in natural language. "
            },
            "begin_planned": "2010-12-01T01:00:00+01:00",
            "begin_effective": "2010-12-01T01:00:00+01:00",
            "end_planned": "2012-11-30T01:00:00+01:00",
            "end_effective": "2013-12-31T01:00:00+01:00",
            "assignment": "2011-05-19T18:33:42+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14026,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 72306,
            "contact": 72306,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1152
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2482-72306-10"
            ]
        },
        {
            "id": 2438,
            "title": {
                "de": "Genvarianten in den RAD51-, XRCC2-, XRCC3-, XPD- und XPG-Genen als Prädiktionsfaktoren für Metastasierung bei PatientInnen mit Weichteilsarkomen",
                "en": "Genetic variants in the RAD51, XRCC2, XRCC3, XPD and XPG genes as predictors of outcome in soft tissue sarcoma patients"
            },
            "short": "SOFT TISSUE SARCOMA PATIENTS",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-12-01T01:00:00+01:00",
            "begin_effective": "2011-04-01T02:00:00+02:00",
            "end_planned": "2011-12-01T01:00:00+01:00",
            "end_effective": "2012-03-30T02:00:00+02:00",
            "assignment": "2011-03-03T12:10:08+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14085,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 69234,
            "contact": 69234,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2438-69234-10",
                "2438-58814-12"
            ]
        },
        {
            "id": 2449,
            "title": {
                "de": "Identifizierung und funktionelle Charakterisierung von neuen Genen in hereditären Neuropathien-Teil II",
                "en": "Identification and functional characterisation of novel genes in hereditary neuropathies - Part II"
            },
            "short": "NOVEL GENES IN HEREDITARY NEUROPATHIES",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-12-01T01:00:00+01:00",
            "begin_effective": "2011-04-01T02:00:00+02:00",
            "end_planned": "2013-11-30T01:00:00+01:00",
            "end_effective": "2015-03-31T02:00:00+02:00",
            "assignment": "2011-03-22T13:43:11+01:00",
            "program": 72,
            "subprogram": null,
            "organization": 14080,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P23223",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2365,
            "title": {
                "de": "Plasmakonzentration und genetische Polymorphismen von PCSK9 in Patienten mit koronarer Herzkrankheit",
                "en": "Plasma concentration and polymorphisms of PCSK9 in patients with coronary artery disease "
            },
            "short": "PCSK9",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-01-01T01:00:00+01:00",
            "end_planned": "2012-01-31T01:00:00+01:00",
            "end_effective": "2012-01-31T01:00:00+01:00",
            "assignment": "2010-12-20T12:47:35+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14028,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50886,
            "contact": 50886,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2365-50886-10"
            ]
        },
        {
            "id": 2662,
            "title": {
                "de": "Die Orai Aktivierungs-Maschinerie",
                "en": "Key determinants of the Orai activation machinery - evaluated by a STIM1 conformational sensor"
            },
            "short": "The Orai Activation Machinery",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-01-01T01:00:00+01:00",
            "end_planned": "2013-12-31T01:00:00+01:00",
            "end_effective": "2013-12-31T01:00:00+01:00",
            "assignment": "2011-12-06T13:47:03+01:00",
            "program": 72,
            "subprogram": null,
            "organization": 14011,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 78591,
            "contact": 78591,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P22565",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2662-78591-10"
            ]
        },
        {
            "id": 2366,
            "title": {
                "de": "\"Advanced\" EEG in der Vorhersage des Verlaufs der Alzheimerdemenz\"",
                "en": "\"Advanced\" EEG in the prediction of the clinical course of Alzheimer dementia"
            },
            "short": "EEG und Alzheimer",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-02-01T01:00:00+01:00",
            "end_planned": "2013-12-31T01:00:00+01:00",
            "end_effective": "2015-01-31T01:00:00+01:00",
            "assignment": "2010-12-21T10:16:33+01:00",
            "program": 60,
            "subprogram": null,
            "organization": 14051,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                416
            ],
            "funder_projectcode": "827462",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2363,
            "title": {
                "de": "Detektion der BRAF V600E Mutation in Lentigo Maligna Melanoma",
                "en": "Detection of the BRAF V600E mutation in Lentigo Maligna Melanoma lesions"
            },
            "short": "BRAF V600E",
            "url": null,
            "abstract": {
                "de": "Das maligne Melanom (MM) gilt als eine der aggressivsten Formen von Hautkrebs mit einer hohen\r\nSterblichkeitsrate und oftmals inadäquaten Therapiemöglichkeiten, insbesondere bei\r\nMetastasierung. Die Voraussetzungen für die Gabe neuer, vielversprechender Therapien sind die\r\npräzise Diagnose und das Wissen über den Mutationsstatus des Tumors.\r\nDie Diagnose der Lentigo maligna melanoma (LMM), einer Sonderform des MM, wird durch klinische\r\nund histopathologische Ähnlichkeiten mit pigmentierter aktinischer Keratose (in situ\r\nPlattenepithelkarzinom) und solarer Lentigo („einfacher Pigmentfleck“ oder „Altersfleck“) erschwert.\r\nÜber den genetischen Charakter von LMM (insbesondere hinsichtlich BRAF), aber auch solarer\r\nLentigo ist bisher nur wenig bekannt.\r\nDie BRAF V600E Mutation ist das am häufigsten detektierte onkologische Ereignis beim MM. In der\r\nvorliegenden Studie wird der Mutationsstatus von BRAF V600E in einem genau charakterisierten\r\nKollektiv aus FFPE LMM Gewebeproben analysiert. Dazu werden drei verschiedene, auf PCR\r\nbasierende, Methoden zur Mutationsanalyse optimiert und validiert. Die BRAF V600E\r\nMutationshäufigkeit wird in einem großem LMM Kollektiv bestimmt und ihre diagnostische und\r\nklinische Relevanz durch den Vergleich mit dem Mutationsstatus bei aktinischer Keratose und solarer\r\nLentigo evaluiert. Die Ergebnisse dieser Studie sollen zur Verbesserung der Diagnostik und\r\nDifferenzialdiagnostik und auch der Therapie des MM beitragen.",
                "en": "Malignant melanoma (MM) is considered the most aggressive form of skin cancers with a high\r\nmortality and often ineffective treatment, especially for metastasis. Prerequisites for the application\r\nof new and promising therapies are the precise diagnosis and the knowledge of the mutational status\r\nof the tumor.\r\nDiagnosis of Lentigo maligna melanoma (LMM), a special form of MM, is complicated since\r\npigmented actinic keratosis (in situ squamous cell carcinoma) and solar lentigo (‘senile freckle’) can\r\nresemble LMM clinically and histopathologically. Only few data is available concerning the genetic\r\ncharacter of both LMM and solar lentigo (especially regarding BRAF).\r\nThe BRAF V600E mutation is the most frequent oncogenic event detected in MM. The study at hand\r\nwill analyze the BRAF V600E mutational status in a well characterized collective of FFPE LMM tissue\r\nsamples. For this purpose we will optimize and validate three different PCR based methods for\r\nmutational analysis. The incidence of the BRAF V600E mutation will be determined in a large LMM\r\ncollective and the diagnostic and clinical relevance of mutated BRAF will be evaluated by comparison\r\nwith that in pigmented actinic keratosis and solar lentigo. The results of this study should help to\r\nimprove the diagnostics means and contribute to advance therapy options of MM."
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-01-01T01:00:00+01:00",
            "end_planned": "2012-06-30T02:00:00+02:00",
            "end_effective": "2012-06-30T02:00:00+02:00",
            "assignment": "2010-12-16T11:07:50+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14085,
            "category": 10,
            "type": 10,
            "partner_function": null,
            "manager": 50563,
            "contact": 50563,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2363-50229-12",
                "2363-50563-10",
                "2363-51066-12",
                "2363-51618-11"
            ]
        },
        {
            "id": 2293,
            "title": {
                "de": "Die pulmonale Mikrozirkulation bei Sepsis und Adipositas",
                "en": "Pulmonary Microcirculation during Sepsis and Obesity – The Role of Cytokines and Adhesion Molecules"
            },
            "short": "PULMONALE MIKROZIRK SEPSIS ADIPOS",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2010-11-01T01:00:00+01:00",
            "end_planned": "2013-12-31T01:00:00+01:00",
            "end_effective": "2015-10-31T01:00:00+01:00",
            "assignment": "2010-09-07T13:56:50+02:00",
            "program": 72,
            "subprogram": null,
            "organization": 14049,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50778,
            "contact": 50778,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P22567",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2293-50778-10"
            ]
        },
        {
            "id": 2395,
            "title": {
                "de": "Mechanische Änderungen von Musculus Triceps Surae im Laufe des  Skelettwachstums - funktionelle Beurteilung von Kontrakturen bei Kindern mit spastischer diplegischer Zerebralparese",
                "en": "Mechanical changes of triceps surae muscle with skeletal growth - functional evaluation of contractures in children with spastic diplegic cerebral palsy"
            },
            "short": "MECHANICAL CHANGES SKELETAL GROWTH",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-01-01T01:00:00+01:00",
            "end_planned": "2012-12-31T01:00:00+01:00",
            "end_effective": "2013-02-28T01:00:00+01:00",
            "assignment": "2011-02-04T12:14:35+01:00",
            "program": null,
            "subprogram": "Österreichische Akademie der Wissenschaften -\r\nAustrian Programme for Advanced Research and Technology ",
            "organization": 14049,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 65038,
            "contact": 65038,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                15
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2395-65038-10"
            ]
        },
        {
            "id": 2448,
            "title": {
                "de": "Onco Track - Methods for systematic next generation oncology biomarker development",
                "en": "Onco Track - Methods for systematic next generation oncology biomarker development"
            },
            "short": "OncoTrack",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-01-01T01:00:00+01:00",
            "end_planned": "2015-12-31T01:00:00+01:00",
            "end_effective": "2016-12-31T01:00:00+01:00",
            "assignment": "2011-03-22T10:18:00+01:00",
            "program": 24,
            "subprogram": "IMI_FP7-Health.2010.4.2.9-6:Integrated data analyses and servicing.",
            "organization": 14020,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": "115234",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2450,
            "title": {
                "de": "Expression von SUMO-Proteinen bei Tumoren des zentralen Nervensystems",
                "en": "Expression von SUMO-Proteinen bei Tumoren des zentralen Nervensystems"
            },
            "short": "SUMOylierung bei ZNS-Tumoren",
            "url": null,
            "abstract": {
                "de": "Die Funktion zahlreicher Proteine wird durch einen, SUMOylierung genannten Prozess, eine reversible Bindung von SUMO-Proteinen an Zielsubstrate, modifiziert. Der Einfluss der SUMOylierung auf die Entstehung und das Wachstum von Tumoren ist bislang erst ansatzweise untersucht worden. In diesem mehrstufigen Forschungsprojekt soll die Expression von SUMO-Proteinen in Hirntumorzelllinien und am Tumorfrischmaterial von Tumoren des zentralen Nervensystems untersucht werden. Es soll darüber hinaus überprüft werden, wie sich die Expression von SUMO-Proteinen in Gegenwart zytostatischer (zellwachstumshemmender) Medikamente verändert. Das Projekt soll zum besseren Verständnis der Bedeutung von molekularbiologischen Veränderungen bei Hirntumoren führen. Daraus können sich weitere Hinweise auf Resistenzmechanismen von Tumorzellen gegenüber zytostatischen Einflüssen ergeben.",
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-04-01T02:00:00+02:00",
            "end_planned": "2013-12-31T01:00:00+01:00",
            "end_effective": "2014-03-31T02:00:00+02:00",
            "assignment": "2011-03-22T15:09:48+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14092,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51369,
            "contact": 51369,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1550
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2450-51369-10"
            ]
        },
        {
            "id": 2394,
            "title": {
                "de": "CXCL13 Chemokin als neuer Biomarker bei systemischer Sklerodermie",
                "en": "CXCL13 Chemokine - a putative biomarker in systemic sclerosis"
            },
            "short": "CXCL13 bei Sklerodermie",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-04-01T02:00:00+02:00",
            "end_planned": "2012-06-01T02:00:00+02:00",
            "end_effective": "2012-09-30T02:00:00+02:00",
            "assignment": "2011-02-04T11:58:45+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14047,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2384,
            "title": {
                "de": "Mobile Teledermatologie in der Behandlung von Akne-Patienten",
                "en": "Use of Mobile Teledermatology in the Care of Acne Patients"
            },
            "short": "Mobile Acne Care",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-04-01T02:00:00+02:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2012-12-31T01:00:00+01:00",
            "assignment": "2011-01-24T15:38:08+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14047,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51711,
            "contact": 51711,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2384-51711-10"
            ]
        },
        {
            "id": 2546,
            "title": {
                "de": "MSc in Migrant Health: Adressing New Challenges in Europe",
                "en": "MSc in Migrant Health: Adressing New Challenges in Europe"
            },
            "short": "MSC IN MIGRANT HEALTH",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2010-10-01T02:00:00+02:00",
            "end_planned": "2013-12-31T01:00:00+01:00",
            "end_effective": "2013-09-30T02:00:00+02:00",
            "assignment": "2011-07-28T12:19:44+02:00",
            "program": null,
            "subprogram": "Erasmus",
            "organization": 29447,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 51521,
            "contact": 51521,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2546-51521-10"
            ]
        },
        {
            "id": 4261,
            "title": {
                "de": "TRPC\u2029 modulation \u2029by \u2029PKG\u2029 and \u2029Muscular \u2029Dystrophy",
                "en": "TRPC\u2029 modulation \u2029by \u2029PKG\u2029 and \u2029Muscular \u2029Dystrophy"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-04-01T02:00:00+02:00",
            "end_planned": "2012-06-30T02:00:00+02:00",
            "end_effective": "2012-09-30T02:00:00+02:00",
            "assignment": "2016-02-01T10:37:22+01:00",
            "program": 101,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 58906,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                15
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4261-58906-10"
            ]
        },
        {
            "id": 2359,
            "title": {
                "de": "Hochauflösende Analyse zirkulierender Tumorzellen beim Mammakarzinom",
                "en": "High-resolution analysis of circulating tumor cells from patients with breast cancer"
            },
            "short": "CIRCULATING TUMOR CELLS",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-01-01T01:00:00+01:00",
            "end_planned": "2012-12-31T01:00:00+01:00",
            "end_effective": "2012-12-31T01:00:00+01:00",
            "assignment": "2010-12-15T13:15:03+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14021,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 57423,
            "contact": 57423,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2359-57423-10"
            ]
        },
        {
            "id": 3226,
            "title": {
                "de": "Von Hypertrophie zur Herzinsuffizienz-die Rolle des spontanen SR Ca2+ Lecks",
                "en": "From hypertrophy to heart failure-the role of spontaneous SR Ca2+ leak"
            },
            "short": "MUG Start",
            "url": null,
            "abstract": {
                "de": null,
                "en": "Heart failure (HF) is a leading cause of death in the developed countries. Despite considerable progress in the past decade in our understanding of cellular and molecular mechanisms involved in the progression of HF, therapeutic agents that specifically target the underlying cellular defects remain rare and ineffective. In HF, intracellular Ca2+ homeostasis is altered and increased cytosolic Ca2+ has been proposed as a potential activator of hypertrophic signalling cascades, ultimately culminating in overt HF phenotype. Recent studies pointed out that increased spontaneous Ca2+ release (Ca2+ leak) from the sarcoplasmic reticulum (SR) Ca2+ release channel (ryanodine receptor, RyR2) due to defective regulation of the RyR2 occurs during HF and causes contractile dysfunction and development of arrhythmias. However, it remains controversial whether increased SR Ca2+ leak is an epiphenomenon accompanying HF only or a pathophysiologically relevant process contributing to accelerated decompensation from hypertrophy to HF.\r\nIn the proposed project, we will pursue the hypothesis, that an increased spontaneous SR Ca2+ leak per se is causally involved in accelerated decompensation from cardiac hypertrophy to HF. We will take advantage of the minimally invasive transverse aortic constriction (TAC) as a pressure overload model for HF, and apply it to a mouse model with an inherited SR Ca2+ leak (knock-in RyR2R4496C+/- human mutation). Our preliminary results show strikingly increased hypertrophy and accelerated transition from hypertrophy to HF in RyR2R4496C+/- hearts after TAC, confirming our initial hypothesis. In the current project, we aim to identify the mechanism(s) of the transition from hypertrophy to overt HF. We will investigate, whether congenital SR Ca2+ leak in RyR2R4496C+/- cardiomyocytes is increased after TAC and, subsequently, leads to alterations in expression and/or phosphorylation pattern of Ca2+ regulatory proteins and transcription factors involved in Ca2+-dependent hypertrophic signalling pathways. Using in vivo ECG recordings, we will further determine the cause for premature cardiac death in RyR2R4496C+/--TAC mice. Additionally, rescue experiments will reveal, whether a putative RyR2 stabilizer (JTV-519) effectively decelerates the HF progression. \r\nWe anticipate that these results will help to define a new role for SR Ca2+ release in the transition from cardiac hypertrophy to HF. Since abnormal RyR2 Ca2+ release is regarded as the underlying mechanism for contractile dysfunction and arrhythmias, this project may contribute to the identification of novel molecular therapeutic targets in HF and thus, possibly improve clinical outcome in HF patients in the future.\r\n"
            },
            "begin_planned": "2011-01-01T01:00:00+01:00",
            "begin_effective": "2011-01-01T01:00:00+01:00",
            "end_planned": "2013-12-31T01:00:00+01:00",
            "end_effective": "2013-12-31T01:00:00+01:00",
            "assignment": "2013-04-02T15:52:03+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 60041,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                894
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3226-60041-10"
            ]
        },
        {
            "id": 2897,
            "title": {
                "de": "Einfluss inflammatorischer Signale auf die myeloide Zelldifferenzierung",
                "en": "Myeloid lineage plasticity in response to inflammatory signals"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-02-01T01:00:00+01:00",
            "begin_effective": "2012-06-15T02:00:00+02:00",
            "end_planned": "2013-04-30T02:00:00+02:00",
            "end_effective": "2014-04-30T02:00:00+02:00",
            "assignment": "2012-04-15T13:14:47+02:00",
            "program": 72,
            "subprogram": null,
            "organization": 14014,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P23215",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2390,
            "title": {
                "de": "Suche genetischer Faktoren in Neurotrophinen beim primären Offenwinkelglaukom",
                "en": "Candidate Gene Analysis in Neurotrophins in Primary Open Angle Glaucoma using Haplotype Tagging Single Nucleotide Polymorphisms"
            },
            "short": "CANDIDATE GENE ANALYSIS_GLAUCOMA",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-02-01T01:00:00+01:00",
            "begin_effective": "2011-04-01T02:00:00+02:00",
            "end_planned": "2013-01-31T01:00:00+01:00",
            "end_effective": "2012-03-31T02:00:00+02:00",
            "assignment": "2011-02-04T09:28:08+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14043,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2379,
            "title": {
                "de": "Die Bedeutung der Th9-Achse bei Psoriasis ",
                "en": "The role of Th9 in psoriasis"
            },
            "short": "TH9_PSORIASIS",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-02-01T01:00:00+01:00",
            "begin_effective": "2011-02-01T01:00:00+01:00",
            "end_planned": "2012-01-31T01:00:00+01:00",
            "end_effective": "2012-01-31T01:00:00+01:00",
            "assignment": "2011-01-17T10:12:57+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14047,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51618,
            "contact": 51618,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1161
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2379-51618-10"
            ]
        }
    ]
}