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GET /v1/research/project/?format=api&offset=360&ordering=end_effective
{ "count": 2261, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=380&ordering=end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=340&ordering=end_effective", "results": [ { "id": 2607, "title": { "de": "Die Rolle der Phospholipid-Scramblase 1 (PLSCR1) in der Differenzierung und Fusion von humanen Trophoblasten ", "en": "The role of Phospholipid-Scramblase 1 (PLSCR1) in human trophoblast differentiation and fusion" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-13T02:00:00+02:00", "begin_effective": "2011-05-13T02:00:00+02:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2011-11-30T01:00:00+01:00", "assignment": "2011-10-05T11:53:24+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 53232, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2607-53232-10" ] }, { "id": 1725, "title": { "de": "Role of T regulatory cells in polymorphic light eruption", "en": "Role of T regulatory cells in polymorphic light eruption" }, "short": "polymorphic light eruption", "url": null, "abstract": { "de": "Die polymorphe Lichtdermatose (PLD- \"Sonnenallergie\"), deren Prävalenz (mit bis zu 20%) vor allem bei jungen Frauen außerordentlich hoch ist, ist durch an sonnenexponierten Körperstellen auftretende, stark juckende Hautveränderungen gekennzeichnet. Die Ätiopathogenese der PLD ist unbekannt, eine Störung der UV-induzierten Immunsuppression mit Immunreaktionen gegen Photoneoantigene der Haut wird vermutet. Bei der Immunsuppression nach UV-EInwirkung kommt den regulatorischen T-Zellen (CD4+CD25+FoxP3+) (Tregs), einer Subpoulation der T-Helfer Zellen, eine bedeutende Rolle zu.\r\nIm vorliegenden Projekt soll die Hypothese geprüft werden, dass Tregs von PLD-Patienten pathogenetisch bedeutsam im Jahresverlauf abnormal fluktuierende Spiegel und Funktionen aufweisen, welche möglicherweise durch Photohardening (UV-Abhärtung) normalisierbar sind. Aus einem besseren Verständnis der Pathogenese der PLD könnten möglicherweise Ansätze für neue therapeutische Strategien resultieren.", "en": "Die polymorphe Lichtdermatose (PLD- \"Sonnenallergie\"), deren Prävalenz (mit bis zu 20%) vor allem bei jungen Frauen außerordentlich hoch ist, ist durch an sonnenexponierten Körperstellen auftretende, stark juckende Hautveränderungen gekennzeichnet. Die Ätiopathogenese der PLD ist unbekannt, eine Störung der UV-induzierten Immunsuppression mit Immunreaktionen gegen Photoneoantigene der Haut wird vermutet. Bei der Immunsuppression nach UV-EInwirkung kommt den regulatorischen T-Zellen (CD4+CD25+FoxP3+) (Tregs), einer Subpoulation der T-Helfer Zellen, eine bedeutende Rolle zu.\r\nIm vorliegenden Projekt soll die Hypothese geprüft werden, dass Tregs von PLD-Patienten pathogenetisch bedeutsam im Jahresverlauf abnormal fluktuierende Spiegel und Funktionen aufweisen, welche möglicherweise durch Photohardening (UV-Abhärtung) normalisierbar sind. Aus einem besseren Verständnis der Pathogenese der PLD könnten möglicherweise Ansätze für neue therapeutische Strategien resultieren." }, "begin_planned": "2009-01-01T01:00:00+01:00", "begin_effective": "2009-01-01T01:00:00+01:00", "end_planned": "2010-12-31T01:00:00+01:00", "end_effective": "2011-11-30T01:00:00+01:00", "assignment": "2009-01-16T14:41:21+01:00", "program": 79, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 51618, "contact": 51618, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1725-54011-12", "1725-51618-10" ] }, { "id": 825, "title": { "de": "MPO-modifiziertes High-Density Lipoprotein und Rezeptoren", "en": "MPO-modified high-density lipoprotein and receptors" }, "short": "MPO-mod. HD LDL", "url": null, "abstract": { "de": "The vascular endothelium is a wide spread organ responsible for the regulation of hemodynamics, angiogenic vascular remodeling, metabolic, synthetic, antiinflammatory, and antithrombogenic processes. Diminished nitric oxide (NO) availability has been linked to vascular disease and a heightened state of inflammation is characterized, in part, by an increase in vascular myeloperoxidase and proteins in vivo modified by its principal oxidant, hypochlourous acid/hypochlorous acid/hypochlorite (HOCI/OCI). Modification of high-density lipoprotein (HDL) by HOCI generates a proatherogenic and proinflammatory lipoprotein particle. HOCI-HDL, present in human lesions material and on endothelial cells, attenuates the expression and activity of vasuloprotective endothelial NO synthase (eNOS). Therefore, one part of this application is to clarify the mechanisms that governs interaction of HODI-HDL and its lipid (plasmalogen)-derived oxidant 2-chlorohexadecanal with eNOS, to focus whether caveolae-located proteins are involved, to profile alterations in endothelial gene expression patterns, and to investigate endothelium-dependent vascular relaxation in aortic rings and perfused vessels. As endothelial dysfunction may be induced by receptor-ligand interaction, the other part of this application will focus on interaction of HOCI-HDL with candidate receptors mediating (patho)physiologically relevant cellualar responses, i.e. activation of transcription factors, kinases and production of cytokines, leadng to the perpetuation of the inflammatory response and endothelial dysfunction. To answer these questions cell lines overexpressing candidate receptors will be used before adapting the cellular signaling cascade patterns to a specific endothelial cell line. We propose that myeloperoxidase-modified HDL- a unique and clinically significant marker for atherosclerosis - mediates endothelial dysfunction by specific receptor-evoked intracellular signaling pathways. ", "en": "The vascular endothelium is a wide spread organ responsible for the regulation of hemodynamics, angiogenic vascular remodeling, metabolic, synthetic, antiinflammatory, and antithrombogenic processes. Diminished nitric oxide (NO) availability has been linked to vascular disease and a heightened state of inflammation is characterized, in part, by an increase in vascular myeloperoxidase and proteins in vivo modified by its principal oxidant, hypochlourous acid/hypochlorous acid/hypochlorite (HOCI/OCI). Modification of high-density lipoprotein (HDL) by HOCI generates a proatherogenic and proinflammatory lipoprotein particle. HOCI-HDL, present in human lesions material and on endothelial cells, attenuates the expression and activity of vasuloprotective endothelial NO synthase (eNOS). Therefore, one part of this application is to clarify the mechanisms that governs interaction of HODI-HDL and its lipid (plasmalogen)-derived oxidant 2-chlorohexadecanal with eNOS, to focus whether caveolae-located proteins are involved, to profile alterations in endothelial gene expression patterns, and to investigate endothelium-dependent vascular relaxation in aortic rings and perfused vessels. As endothelial dysfunction may be induced by receptor-ligand interaction, the other part of this application will focus on interaction of HOCI-HDL with candidate receptors mediating (patho)physiologically relevant cellualar responses, i.e. activation of transcription factors, kinases and production of cytokines, leadng to the perpetuation of the inflammatory response and endothelial dysfunction. To answer these questions cell lines overexpressing candidate receptors will be used before adapting the cellular signaling cascade patterns to a specific endothelial cell line. We propose that myeloperoxidase-modified HDL- a unique and clinically significant marker for atherosclerosis - mediates endothelial dysfunction by specific receptor-evoked intracellular signaling pathways. " }, "begin_planned": "2006-07-01T02:00:00+02:00", "begin_effective": "2006-12-16T01:00:00+01:00", "end_planned": "2009-06-30T02:00:00+02:00", "end_effective": "2011-12-15T01:00:00+01:00", "assignment": "2006-05-16T17:47:52+02:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51833, "contact": 51833, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P19074", "ethics_committee": null, "edudract_number": null, "persons": [ "825-51833-10" ] }, { "id": 2457, "title": { "de": "INTEROCEPTION AND ARTERIAL STIFFNESS", "en": "INTEROCEPTION AND ARTERIAL STIFFNESS" }, "short": "STRESS HYPOXIC CONDITIONS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-04-01T02:00:00+02:00", "begin_effective": "2011-03-28T02:00:00+02:00", "end_planned": "2011-12-30T01:00:00+01:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-03-29T11:56:04+02:00", "program": null, "subprogram": null, "organization": 29447, "category": 10, "type": 10, "partner_function": 4, "manager": 60040, "contact": 60040, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2457-60040-10" ] }, { "id": 2451, "title": { "de": "Ein US28/GNA Fusionsprotein zur Induktion der Apoptose beim Melanom", "en": "A US28/GNA Fusion Protein to Induce Apoptosis in Melanoma " }, "short": "US28/GNA and Melanoma", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-03-01T01:00:00+01:00", "begin_effective": "2011-04-01T02:00:00+02:00", "end_planned": "2011-05-31T02:00:00+02:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-03-23T11:47:48+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 53662, "contact": 53662, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2451-53662-10" ] }, { "id": 2460, "title": { "de": "Etablierung organtypischer Zellkultur für Herzgewebe", "en": "Establishing of organotypic cell culture for heart tissue" }, "short": "ORGANOTYPIC CELL CULTURE HEART TISSUE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-03-01T01:00:00+01:00", "begin_effective": "2011-05-01T02:00:00+02:00", "end_planned": "2011-08-31T02:00:00+02:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-04-07T13:19:02+02:00", "program": null, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2406, "title": { "de": "Adipokine Visfatin und Chemerin im Kindes- und Jugendalter", "en": "The adipokines visfatin and chemerin in childhood and adolescence" }, "short": "ADIPOKINE VISFATIN CHEMERIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-10-01T02:00:00+02:00", "begin_effective": "2011-03-01T01:00:00+01:00", "end_planned": "2011-10-01T02:00:00+02:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-02-15T12:46:08+01:00", "program": null, "subprogram": null, "organization": 14091, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2788, "title": { "de": "Scanningbewegungen des Kopfes als Ausdruck des Schauverhaltens am gehenden Patienten im Low vision Bereich: Entwicklung der Analysemethode und Standardisierung", "en": "Headscanning in Mobility Testing" }, "short": "Headscanning in Mobility Testing", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-01T02:00:00+02:00", "begin_effective": "2011-05-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2012-02-14T15:16:48+01:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 938 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1002, "title": { "de": "EuroSTEC: Soft tissue engineering for congenital birth defects in children: from \"biomatrix - cell interaction - model system\" to clinical trials", "en": "EuroSTEC: Soft tissue engineering for congenital birth defects in children: from \"biomatrix - cell interaction - model system\" to clinical trials" }, "short": "EuroSTEC", "url": null, "abstract": { "de": "The aim of this project is to use modern tissue engineering approaches to treat children with structural disorders present at birth, such as spina bifida, urogenital defects or abdominal wall defects and surrounding anomalies. The project strives to elucidate underlying mechanisms and take a translational route through in vitro and animal experiments.\r\nThis project will give more insight in the opportunities for advanced technical possibilities with tissue engineering techniques and new treatment strategies for severe and major structural congenital birth defects in children. \r\n", "en": "The aim of this project is to use modern tissue engineering approaches to treat children with structural disorders present at birth, such as spina bifida, urogenital defects or abdominal wall defects and surrounding anomalies. The project strives to elucidate underlying mechanisms and take a translational route through in vitro and animal experiments.\r\nThis project will give more insight in the opportunities for advanced technical possibilities with tissue engineering techniques and new treatment strategies for severe and major structural congenital birth defects in children. \r\n" }, "begin_planned": "2006-11-01T01:00:00+01:00", "begin_effective": "2007-01-01T01:00:00+01:00", "end_planned": "2011-10-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2007-01-15T14:22:41+01:00", "program": 21, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2031, "title": { "de": "Genetic variants in the RAD51, BRCA1 and BRCA2 genes as predictors of radiation response and toxicity in prostate cancer patients", "en": "Genetic variants in the RAD51, BRCA1 and BRCA2 genes as predictors of radiation response and toxicity in prostate cancer patients" }, "short": "GENETIC_PROSTATE_CANCER_OeNB", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-01-11T15:12:11+01:00", "program": 79, "subprogram": null, "organization": 14060, "category": 10, "type": 10, "partner_function": 4, "manager": 50495, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2031-50495-10", "2031-50910-12" ] }, { "id": 2498, "title": { "de": "Die Rolle von Metalloproteasen und Endothelin im ersten Schwangerschaftstrimester", "en": "The role of metalloproteinases and endothelin in the first trimester of pregnancy" }, "short": "METALLPROTEINASES_ENDOTHELIN_PREGNANCY", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2011-06-16T12:49:53+02:00", "program": null, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2023, "title": { "de": "Induction of immunological changes by endoluminal photodynamic therapy (PDT) for esophageal carcinoma", "en": "Induction of immunological changes by endoluminal photodynamic therapy (PDT) for esophageal carcinoma" }, "short": "PDT_ESOPHAGEAL_CARCINOMA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2009-12-18T12:29:42+01:00", "program": 79, "subprogram": null, "organization": 14077, "category": 10, "type": 10, "partner_function": 4, "manager": 51615, "contact": 51615, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2023-62056-12", "2023-51615-10", "2023-51618-12" ] }, { "id": 1329, "title": { "de": "Mapping of the bound proton fraction in the elderly brain", "en": "Mapping of the bound proton fraction in the elderly brain" }, "short": "BOUND_PROTON_ELDERLY_BRAIN_FWF07", "url": null, "abstract": { "de": "The aim of this proposal is to investigate whether the bound pool fraction as a new and quantitative MR measure allows more insight into age related brain tissue changes than other quantitative MR measures. The specific aims are:\r\n\r\n*Develop a MR pulse sequence that allows to map the bound proton fraction on high field systems (>=3T) within a clinically reasonable measurement time (<15min). The sequence should offer whole brain coverage and should overcome current limitations such as the susceptibility for motion and B1 effects.\r\n\r\n*Measure the BPF in brain tissue of a large cohort of the Ausitria Stroke Prevention Study (ASPS). This gives us the opportunity to study a representative and homogeneous group of normal elderly people without a history or signs of neuropsychiatric diseases. By using a younger control cohort, we want to investigate how the BPF changes as a function of age, sex and anatonic region including cortical structures. In addition, we want to find out how the BPF varies within WMH with different severity and how it relates to the BPF in normal appearing brain tissue and to the neurocognitive performance.\r\n\r\n*Compare the sensitivity and specificity of bound proton fraction mapping to more established measures of brain tissue changes including atrophy, diffusion weighted imaging, and magnetization transfer imaging.", "en": "The aim of this proposal is to investigate whether the bound pool fraction as a new and quantitative MR measure allows more insight into age related brain tissue changes than other quantitative MR measures. The specific aims are:\r\n\r\n*Develop a MR pulse sequence that allows to map the bound proton fraction on high field systems (>=3T) within a clinically reasonable measurement time (<15min). The sequence should offer whole brain coverage and should overcome current limitations such as the susceptibility for motion and B1 effects.\r\n\r\n*Measure the BPF in brain tissue of a large cohort of the Ausitria Stroke Prevention Study (ASPS). This gives us the opportunity to study a representative and homogeneous group of normal elderly people without a history or signs of neuropsychiatric diseases. By using a younger control cohort, we want to investigate how the BPF changes as a function of age, sex and anatonic region including cortical structures. In addition, we want to find out how the BPF varies within WMH with different severity and how it relates to the BPF in normal appearing brain tissue and to the neurocognitive performance.\r\n\r\n*Compare the sensitivity and specificity of bound proton fraction mapping to more established measures of brain tissue changes including atrophy, diffusion weighted imaging, and magnetization transfer imaging." }, "begin_planned": "2007-08-01T02:00:00+02:00", "begin_effective": "2008-01-01T01:00:00+01:00", "end_planned": "2010-07-31T02:00:00+02:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2007-07-10T14:42:36+02:00", "program": 72, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 51279, "contact": 51279, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P20103", "ethics_committee": null, "edudract_number": null, "persons": [ "1329-51279-10" ] }, { "id": 2341, "title": { "de": "Einzelzellanalyse in der forensischen Medizin", "en": "Single cell analysis in forensic medicine" }, "short": "Single cell analysis", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-05-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2011-04-30T02:00:00+02:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-11-17T11:21:30+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 54171, "contact": 54171, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2341-54171-10" ] }, { "id": 2095, "title": { "de": "Purkinje Topology", "en": "Purkinje Topology" }, "short": "PURKINJE TOPOLOGY", "url": null, "abstract": { "de": "Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. ", "en": "Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. " }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T12:53:47+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 50967, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2095-50967-10" ] }, { "id": 1771, "title": { "de": "Rett Disorder: The Pre-Regression Period", "en": "Rett Disorder: The Pre-Regression Period" }, "short": "RETT DISORDER", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": null, "begin_effective": "2007-01-01T01:00:00+01:00", "end_planned": null, "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2009-03-30T17:24:34+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1610, "title": { "de": "Vitamin D and new bone marker levels in breast cancer patients with and without bone metastases", "en": "Vitamin D and new bone marker levels in breast cancer patients with and without bone metastases" }, "short": "VIT_D_BONE_MARKER_LEVELS", "url": null, "abstract": { "de": "Brustkrebs (BrCa) ist die häufigste Form von Krebs bei Frauen. Das Skelettsystem ist ein bevorzugtes Ziel für Metastasen bei BrCa. Hoher Knochenumsatz erhöht das Risiko für Krankheitsprogression und Tod. Der im Knochenstoffwechsel etablierte Einfluss von Vitamin D3 könnte daher auch ein wichtiger Risikofaktor für Skelettmetastasen sein.\r\nVitamin D3 und Serummarker des Knochenstoffwechsels sollen aus einer großen retrospektiven Kohorte von BrCa-Patientinnen mit einem Pool von 5400 BrCa-Patientinnen an ausgewählten Patientinnen mit (n=1050) und ohne Knochenmetastasen in konsekutiven Serumproben ausgewertet werden. Diese Gruppen werden in Alter und Tumorstadium übereingestimmt und sowohl im Querschnitt als auch im Verlauf nach Knochenmetastasen untersucht. Wir erwarten aus dieser Auswertung neue Perspektiven für Vitamin D3 und Knochenstoffwechselmarker in Pathophysiologie, Diagnose und Verlauf von Knochenmetastasen bei Brustkrebspatientinnen.", "en": "Brustkrebs (BrCa) ist die häufigste Form von Krebs bei Frauen. Das Skelettsystem ist ein bevorzugtes Ziel für Metastasen bei BrCa. Hoher Knochenumsatz erhöht das Risiko für Krankheitsprogression und Tod. Der im Knochenstoffwechsel etablierte Einfluss von Vitamin D3 könnte daher auch ein wichtiger Risikofaktor für Skelettmetastasen sein.\r\nVitamin D3 und Serummarker des Knochenstoffwechsels sollen aus einer großen retrospektiven Kohorte von BrCa-Patientinnen mit einem Pool von 5400 BrCa-Patientinnen an ausgewählten Patientinnen mit (n=1050) und ohne Knochenmetastasen in konsekutiven Serumproben ausgewertet werden. Diese Gruppen werden in Alter und Tumorstadium übereingestimmt und sowohl im Querschnitt als auch im Verlauf nach Knochenmetastasen untersucht. Wir erwarten aus dieser Auswertung neue Perspektiven für Vitamin D3 und Knochenstoffwechselmarker in Pathophysiologie, Diagnose und Verlauf von Knochenmetastasen bei Brustkrebspatientinnen." }, "begin_planned": "2008-07-01T02:00:00+02:00", "begin_effective": "2008-07-01T02:00:00+02:00", "end_planned": "2009-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2008-08-22T12:07:22+02:00", "program": 79, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 51809, "contact": 51809, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1610-51809-10", "1610-51692-12", "1610-57544-12" ] }, { "id": 1868, "title": { "de": "Computer-based analysis of heart rate variability (HRV) during different methods of acupuncture", "en": "Computer-based analysis of heart rate variability (HRV) during different methods of acupuncture" }, "short": "HRV during acupuncture", "url": null, "abstract": { "de": "Die Herzratenvariabilität stellt die prozentuelle Änderung aufeinander folgender Kammerkomplexe im EKG dar. Der Parameter HRV wird durch das Blutdruckkontrollsystem, Einflüsse vom Hypothalamus und vor allem durch den vagalen Teil des Kreislaufzentrums im unteren Hirnstamm vermittelt. Eine computergestützte Analyse der HRV soll während unterschiedlicher Methoden der Akupunktur und anderer Stimulationsmethoden im gegenständlichen Projekt zum Einsatz kommen. Für die Untersuchungen soll ein Medilog AR 12 verwendet werden. Insgesamt sollen 80 Probanden (im Alter 20-50 Jahren) während unterschiedlicher Akupunktursitzungen (Nadel- und Laserakupunktur) untersucht werden. Dabei werden die folgenden Akupunkturpunkte verwendet: Neiguan (Pe.6), Shenmen (He.7) und Hegu (Di.4). Innerhalb dieses Projektes soll die HRV auch während Stimulationen des Punktes Yintang (Ex.1) näher untersucht werden. Das Projekt könnte dazu beitragen, die Beziehungen zwischen westlicher und östlicher Medizin zu vertiefen.", "en": "Die Herzratenvariabilität stellt die prozentuelle Änderung aufeinander folgender Kammerkomplexe im EKG dar. Der Parameter HRV wird durch das Blutdruckkontrollsystem, Einflüsse vom Hypothalamus und vor allem durch den vagalen Teil des Kreislaufzentrums im unteren Hirnstamm vermittelt. Eine computergestützte Analyse der HRV soll während unterschiedlicher Methoden der Akupunktur und anderer Stimulationsmethoden im gegenständlichen Projekt zum Einsatz kommen. Für die Untersuchungen soll ein Medilog AR 12 verwendet werden. Insgesamt sollen 80 Probanden (im Alter 20-50 Jahren) während unterschiedlicher Akupunktursitzungen (Nadel- und Laserakupunktur) untersucht werden. Dabei werden die folgenden Akupunkturpunkte verwendet: Neiguan (Pe.6), Shenmen (He.7) und Hegu (Di.4). Innerhalb dieses Projektes soll die HRV auch während Stimulationen des Punktes Yintang (Ex.1) näher untersucht werden. Das Projekt könnte dazu beitragen, die Beziehungen zwischen westlicher und östlicher Medizin zu vertiefen." }, "begin_planned": "2009-10-01T02:00:00+02:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-09-30T02:00:00+02:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2009-07-13T18:54:46+02:00", "program": 79, "subprogram": null, "organization": 14044, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1868-54121-12" ] }, { "id": 2092, "title": { "de": "Analysis of germline polymorphisms in the VEGF/VEGFR pathway to predict colorectal cancer outcome", "en": "Analysis of germline polymorphisms in the VEGF/VEGFR pathway to predict colorectal cancer outcome" }, "short": "GERMLINE POLYMORPH VEGF/VEGFR", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2010-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T11:47:57+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 59304, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2092-59304-10", "2092-58814-12" ] }, { "id": 2033, "title": { "de": "Mit autologen Thrombozyten angereichertes körpereigenes Fibrin zur Förderung der Wundheilung bei chronischem Ulcus cruris venosum (kontrollierte prospektive randomisierte klinische Studie)", "en": "Mit autologen Thrombozyten angereichertes körpereigenes Fibrin zur Förderung der Wundheilung bei chronischem Ulcus cruris venosum (kontrollierte prospektive randomisierte klinische Studie)" }, "short": " Ulcus cruris venosum Studie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2008-10-01T02:00:00+02:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2009-09-30T02:00:00+02:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-01-12T17:36:20+01:00", "program": null, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": 51612, "contact": 51612, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2033-51612-10" ] } ] }