Project List
List projects.
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GET /v1/research/project/?format=api&offset=360&ordering=-end_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=380&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=340&ordering=-end_effective", "results": [ { "id": 8151, "title": { "de": "Das intestinale Mikrobiom eines orthotopen und eines ektopen Hepatoblastom Mausmodelles", "en": "The Intestinal Microbiome in an Orthotopic and Ectopic Tumor Murine Model of Hepatoblastoma" }, "short": "Microbiome in Hepatoblastoma Mouse Model", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2024-04-24T15:59:17+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 1, "manager": 90375, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8151-50778-12", "8151-90375-10", "8151-97866-12" ] }, { "id": 8745, "title": { "de": "Kardiometabolische und vaskuläre Auswirkungen von Adipositas im Kindesalter", "en": "Cardiometabolic and vascular effects of childhood obesity" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-03-01T01:00:00+01:00", "begin_effective": "2025-04-01T02:00:00+02:00", "end_planned": "2026-02-28T01:00:00+01:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2025-03-28T16:01:35+01:00", "program": null, "subprogram": null, "organization": 14048, "category": 10, "type": 10, "partner_function": 4, "manager": 71568, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8745-71568-10" ] }, { "id": 7328, "title": { "de": "ANEMONE: Die Antwort in der Mikroumgebung: Resistenz des malignen Pleuramesothelioms gegen alte und neue Medikamente", "en": "ANEMONE: The ANswer within the microEnvironment: Malignant pleural mesothelioma resistance to Old and NEw drugs " }, "short": "ANEMONE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-10-01T02:00:00+02:00", "begin_effective": "2022-11-01T01:00:00+01:00", "end_planned": "2025-10-01T02:00:00+02:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2023-01-11T10:20:33+01:00", "program": 112, "subprogram": null, "organization": 14006, "category": 10, "type": 10, "partner_function": 1, "manager": 100911, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I6102", "ethics_committee": null, "edudract_number": null, "persons": [ "7328-100911-10", "7328-119328-12" ] }, { "id": 7764, "title": { "de": "Methodenplattform GeMTeX", "en": "German Medical Text Corpus" }, "short": "GeMTeX", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-09-01T02:00:00+02:00", "begin_effective": "2023-09-01T02:00:00+02:00", "end_planned": "2026-08-31T02:00:00+02:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2023-09-14T15:14:25+02:00", "program": null, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 2, "manager": 60827, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 3058 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7764-60827-10" ] }, { "id": 6661, "title": { "de": "Genetics of COVID-19 risks & resilience in Bipolar Disorder", "en": "Genetics of COVID-19 risks & resilience in Bipolar Disorder" }, "short": "BIP-COVID", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-04-01T02:00:00+02:00", "begin_effective": "2021-09-01T02:00:00+02:00", "end_planned": "2024-04-01T02:00:00+02:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2021-08-03T12:21:19+02:00", "program": 108, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": 79771, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI968", "ethics_committee": null, "edudract_number": null, "persons": [ "6661-79771-10" ] }, { "id": 8425, "title": { "de": "Nanoträger für die selektive Behandlung von HER2+ Brustkrebs", "en": "Nanocarriers for selective HER2+ breast cancer treatment" }, "short": "MIP-Magic", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-03-31T02:00:00+02:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2024-10-07T16:23:56+02:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 3, "manager": 124253, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8425-124253-10" ] }, { "id": 7062, "title": { "de": "AI powered Data Curation & Publishing Virtual Assistant", "en": "AI powered Data Curation & Publishing Virtual Assistant" }, "short": "AIDAVA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-09-01T02:00:00+02:00", "begin_effective": "2022-09-01T02:00:00+02:00", "end_planned": "2026-08-31T02:00:00+02:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2022-06-15T15:10:02+02:00", "program": 211, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 99976, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101057062", "ethics_committee": null, "edudract_number": null, "persons": [ "7062-99976-10", "7062-117162-12", "7062-124636-12" ] }, { "id": 7339, "title": { "de": "Targeting der zellulären Seneszenz basierend auf inter-organellarer Kommunikation, Proteostasis und metabolischer Kontrolle", "en": "Targeting cellular senescence based on inter-organelle communication, multi-level proteostasis and metabolic control " }, "short": "SenioProm", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-03-01T01:00:00+01:00", "begin_effective": "2023-03-01T01:00:00+01:00", "end_planned": "2027-02-28T01:00:00+01:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2023-01-18T15:33:07+01:00", "program": 113, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 85069, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "FG 2400-B", "ethics_committee": null, "edudract_number": null, "persons": [ "7339-85069-10" ] }, { "id": 7058, "title": { "de": "AI powered Data Curation & Publishing Virtual Assistant", "en": "AI powered Data Curation & Publishing Virtual Assistant" }, "short": "AIDAVA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-09-01T02:00:00+02:00", "begin_effective": "2022-09-01T02:00:00+02:00", "end_planned": "2026-08-31T02:00:00+02:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2022-06-15T10:10:24+02:00", "program": 211, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51449, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101057062", "ethics_committee": null, "edudract_number": null, "persons": [ "7058-51449-10", "7058-100777-12", "7058-101604-12", "7058-105945-12", "7058-117162-12", "7058-51050-12", "7058-125115-12" ] }, { "id": 9597, "title": { "de": "Die Rolle von Kollagen IV und seiner Matrikine in der pulmonalen Fibrose.", "en": "The role of collagen IV and it matrikines in pulmonary fibrosis." }, "short": "Col4 matrikines in IPF", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-12-01T01:00:00+01:00", "begin_effective": "2025-12-01T01:00:00+01:00", "end_planned": "2026-08-31T02:00:00+02:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2026-02-09T10:27:58+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 99630, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9597-99630-10" ] }, { "id": 6899, "title": { "de": "Wir alle sind Mischwesen: Mikrochimärsimus, Gesundheit und Evolution", "en": "We All Are Multitudes: the Microchimerism, Human Health and Evolution" }, "short": "Microchimerism and Evolution", "url": "https://www.microchimerism.info/", "abstract": { "de": "Mikrochimärismus (MC) beschreibt die Existenz einer kleinen Anzahl fremder menschlicher Zellen in einer Person. Dieses Phänomen entsteht unter anderem während der Schwangerschaft durch das Wandern von Zellen zwischen Mutter und Fötus. Das derzeitige Wissen um MC ist unvollständig und teils widersprüchlich, über die Rolle, die mikrochimäre Zellen in der Wirtsphysiologie spielen, ist wenig bekannt.\r\nWas ist der Grund der anscheinend paradoxen Effekte von MC? Welche Mechanismen sind beteiligt oder sogar verantwortlich dafür, dass mikrochimäre Zellen ins Wirtsgewebe wandern, sich dort integrieren und oftmals ein Wirtsleben lang verbleiben? Die Evolutionsbiologie und die maternal-fetale Konflikttheorie können einen Rahmen bieten, um die Persistenz mikrochimärer Zellen zu verstehen und deren Existenz mit einer erhöhten Anfälligkeit für Krankheiten zu verknüpfen.\r\nWir gehen zunächst davon aus, dass MC weiter verbreitet ist als bisher berichtet. Wir nehmen weiters an, dass mikrochimäre Zellen eine adaptive Rolle in der Physiologie des Wirts zu spielen vermögen und Vorteile für Mütter und Nachkommen bieten können, etwa durch Übertragung von Stammzellen und anderen Zelltypen aber auch durch Übertragung von wichtigen Komponenten des und Signalen für das Immunsystem. Jedoch werden sich in manchen Geweben die maternal-fötalen genetischen Interessen nicht zur Deckung bringen lassen, was eine erhöhte Anfälligkeit für Krankheiten zur Folge haben kann. Daher ist es unser Ziel, den Einfluss des MC auf Gesundheit und Krankheit zu studieren und Potential und Effekte des Zelltransfers über Generationengrenzen hinweg zu verstehen.\r\nBasis unseres Projekts ist die Verwendung modernster Technologien zur Analyse des bidirektionalen Transfers mikrochimärer Zellen zwischen Individuen und die Verteilung der mikrochimären Zellen in den Zielgeweben. Weiters widmen wir uns den Effekten, die aus der Interaktion von mikrochimären Zellen und dem Immunsystem des Wirts hervorgehen. Diese Themen studieren wir in mehreren Teilprojekten: Erstellung eines Maus-Mikrochiom-Atlas (Projekt 1), Phänotypisierung von maternalem (Projekt 2) und fetalem (Projekt 3) MC, Charakterisierung von mikrochimären Zellen in plazentanahen, -fernen Geweben und diversen Organen (Projekt 4) sowie den Zusammenhang von MC und Autoimmunerkrankung im Tiermodell (Projekt 5).\r\nUnsere Forschung dient dem Verständnis der Interaktion von mikrochimären Zellen mit dem Wirt und zur Klärung der Fragen, wie die Toleranz von MC während der Schwangerschaft und postpartum bei Müttern gewährleistet und aufrecht erhalten werden kann, welche Auswirkungen MC auf die frühe Entwicklung von Föten hat und ob es während Krankheiten zum Zusammenbruch der Immuntoleranz kommt und welche Ursachen dies hat.", "en": "Microchimerism (MC) is the harboring of a small number of cells between two distinct individuals. This transfer of cells is well known to occur between mothers and offspring during gestation, though other avenues of transfer may be possible. The current understanding of MC is puzzling and little is known about the role microchimeric cells play in host physiology.\r\nWhy are the effects of MC paradoxical and what are the mechanisms responsible for maintaining microchimeric cells over an organism’s lifetime? Evolutionary biology and maternal-fetal conflict theory can provide a framework to understand the persistence of microchimeric cells, and how this may lead to disease vulnerability.\r\nWe hypothesize MC is much more common than previously reported and microchimeric cells play an adaptive role in host physiology, providing benefits for both mothers and offspring through transfers of stem and other cell types, and providing key immune system components and signals. However, in certain host tissues the maternal-fetal genetic interests may not align, potentially leading to disease vulnerability.\r\nWe aim to understand the role MC plays in health and disease, and understand the potential for and effects of subsequent generational transfers of microchimeric cells. We will use cutting edge technology to characterize MC cell distribution and trafficking between hosts and the effects of MC-host immune system interactions in various host tissues by creating a mouse Microchiome Atlas (Project 1), phenotyping human maternal MC (mMC) (Project 2), phenotyping human fetal MC (fMC) (Project 3), phenotyping microchimeric cells proximal and distal in terms of distance from the maternal-fetal interface as well as in various other organs (Project 4), and interrogating the context of MC and autoimmune disease in animal models (Project 5).\r\nOur research will determine how microchimeric cells interact with the host system to initiate and maintain tolerance of MC during pregnancy, the postpartum period for mothers and early development in offspring, and uncover if there is a breakdown in immune tolerance during disease states, and what causes it." }, "begin_planned": "2022-02-01T01:00:00+01:00", "begin_effective": "2021-12-01T01:00:00+01:00", "end_planned": "2024-10-31T01:00:00+01:00", "end_effective": "2026-08-30T02:00:00+02:00", "assignment": "2022-02-01T12:59:33+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 3, "manager": 54171, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2575 ], "funder_projectcode": "62214", "ethics_committee": null, "edudract_number": null, "persons": [ "6899-104057-12", "6899-54171-10", "6899-82600-12", "6899-104139-12", "6899-114270-12", "6899-115382-12", "6899-116463-12" ] }, { "id": 8381, "title": { "de": "Von der Entstehung einer Arrhythmie bis zur Progression: Aufdeckung der molekularen Mechanismen, die Herzrhythmusstörungen stabilisieren", "en": "From arrhythmia initiation to progression: uncovering the molecular mechanisms stabilizing cardiac arrhythmias using a computational-experimental approach" }, "short": "NWOVidi", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-06-01T02:00:00+02:00", "begin_effective": "2024-06-01T02:00:00+02:00", "end_planned": "2026-08-14T02:00:00+02:00", "end_effective": "2026-08-14T02:00:00+02:00", "assignment": "2024-09-05T19:11:41+02:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 123850, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8381-123850-10" ] }, { "id": 6639, "title": { "de": "Erstellung von Metabolomprofilen aus Plasma und Liquor von Kindern mit seltenen neurologischen Erkrankungen ", "en": "Establishment of plasma and cerebrospinal fluid metabolome profiles of rare neurological diseases in children" }, "short": "Metabolomics/Lipidomics in rare diseases", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-07-01T02:00:00+02:00", "begin_effective": "2021-08-15T02:00:00+02:00", "end_planned": "2024-06-30T02:00:00+02:00", "end_effective": "2026-08-14T02:00:00+02:00", "assignment": "2021-07-06T15:39:00+02:00", "program": 86, "subprogram": null, "organization": 14048, "category": 10, "type": 10, "partner_function": 4, "manager": 84507, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "T1343", "ethics_committee": null, "edudract_number": null, "persons": [ "6639-50450-12", "6639-84507-10", "6639-58455-12", "6639-127259-12" ] }, { "id": 8277, "title": { "de": "Untersuchung des pro-fibrotischen Potenzials von B-Zellen in der Haut bei systemischer Sklerose", "en": "Investigating the pro-fibrotic potential of B cells in the skin niche during Systemic Sclerosis" }, "short": "SScSkin", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-08-01T02:00:00+02:00", "begin_effective": "2024-08-01T02:00:00+02:00", "end_planned": "2026-07-31T02:00:00+02:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2024-06-27T13:46:39+02:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 3, "manager": 120271, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8277-115661-12", "8277-120271-10", "8277-131740-12" ] }, { "id": 7086, "title": { "de": "Piezo1 in der Plazenta verbindet Lipide mit Gefäßfunktion", "en": " Piezo1 couples lipids and vascular function in the placenta" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-07-01T02:00:00+02:00", "begin_effective": "2022-08-01T02:00:00+02:00", "end_planned": "2025-06-30T02:00:00+02:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2022-07-06T10:07:59+02:00", "program": 124, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 113634, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "ESP 167", "ethics_committee": null, "edudract_number": null, "persons": [ "7086-50442-12", "7086-56938-12", "7086-59816-12", "7086-100813-12", "7086-113409-12", "7086-113634-10", "7086-114912-12", "7086-119149-12", "7086-125737-12", "7086-130675-12", "7086-128676-12" ] }, { "id": 9130, "title": { "de": "Auf dem Weg zu einem umfassenden Atlas des menschlichen Atmungsmikrobioms: Taxonomische, genomische und funktionelle Perspektiven", "en": "Towards a Comprehensive Atlas of the Human Respiratory Microbiome: Taxonomic,\r\nGenomic, and Functional Perspectives" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-08-01T02:00:00+02:00", "end_planned": "2025-01-01T01:00:00+01:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2025-08-05T13:14:59+02:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 90021, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9130-90021-10" ] }, { "id": 9068, "title": { "de": "Zelltypspezifische in vivo Depletion proliferierender Zellen - Charakterisierung eines einzigartigen neuen genetischen Mausmodells", "en": "Cell-type specific in vivo ablation of proliferating cells – characterization of a unique novel genetic mouse model" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-08-01T02:00:00+02:00", "begin_effective": "2025-08-01T02:00:00+02:00", "end_planned": "2026-07-31T02:00:00+02:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2025-07-04T12:12:41+02:00", "program": null, "subprogram": null, "organization": 14006, "category": 10, "type": 10, "partner_function": 1, "manager": 61540, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9068-61540-10" ] }, { "id": 7619, "title": { "de": "Umfassende genetische Analyse von Patienten und Patientinnen mit Auftreten einer Krebserkrankung in jüngerem Alter", "en": "Comprehensive genetic analysis of patients with onset of cancer at a younger age" }, "short": "CotY", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-05-01T02:00:00+02:00", "begin_effective": "2023-07-01T02:00:00+02:00", "end_planned": "2025-04-30T02:00:00+02:00", "end_effective": 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