Project List
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GET /v1/research/project/?format=api&offset=360&ordering=-end_effective
{ "count": 2244, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=380&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=340&ordering=-end_effective", "results": [ { "id": 7923, "title": { "de": "Die Zukunft im Blick: Alterung des Immunsystems als prädiktiver Marker für Autoimmunerkrankungen in jungen gesunden Individuen\r\n", "en": "The Future in Focus: Aging of the Immune System as a Predictive Marker for Autoimmune Diseases in Young Healthy Individuals" }, "short": "Aging Immune System_Autoimmune Diseases", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2023-12-12T10:50:37+01:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 1, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 7913, "title": { "de": "NeEDs - necessary decision support system", "en": "NeEDs - necessary decision support system" }, "short": "NeEDs", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2023-12-05T10:18:58+01:00", "program": null, "subprogram": null, "organization": 14076, "category": 10, "type": 10, "partner_function": 4, "manager": 78071, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1040 ], "funder_projectcode": "1.000.072.603", "ethics_committee": null, "edudract_number": null, "persons": [ "7913-78071-10" ] }, { "id": 9502, "title": { "de": "Der periphere (muskuläre) Oxygenierungs- und Perfusions-Score (POP-Score): ein neues nicht-invasives Instrument zur Vorhersage erhöhter C-reaktiver Proteinwerte bei Neugeborenen – eine prospektive beobachtende Phase-II-Studie", "en": "The peripheral(-muscle) oxygenation and perfusion Score (POP Score): a new non-invasive tool to predict elevations in C-reactive protein levels in neonates – a prospective Phase II observational study " }, "short": "POP-Score ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-11-01T01:00:00+01:00", "begin_effective": "2026-01-01T01:00:00+01:00", "end_planned": "2027-11-01T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2025-12-17T15:13:35+01:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 82050, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9502-82050-10" ] }, { "id": 6971, "title": { "de": "Mütterliche Blutplättchen und extravillöse Trophoblasten", "en": "Maternal platelets and extravillous trophoblasts" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-03-01T01:00:00+01:00", "begin_effective": "2022-09-01T02:00:00+02:00", "end_planned": "2025-02-28T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2022-03-24T09:19:41+01:00", "program": 72, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 53232, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P35118", "ethics_committee": null, "edudract_number": null, "persons": [ "6971-53232-10" ] }, { "id": 7984, "title": { "de": "Gewebe-infiltrierende Lymphozyten - Direkte Evaluierung der Rezeptoren ", "en": "Tissue-infiltrating Lymphocytes - Direct Evaluation of Receptors " }, "short": "TIL-DER", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-04-01T02:00:00+02:00", "begin_effective": "2024-04-01T02:00:00+02:00", "end_planned": "2025-09-30T02:00:00+02:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2024-01-19T12:01:27+01:00", "program": 117, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 97234, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7984-97234-10" ] }, { "id": 6852, "title": { "de": "Anomalien im Fettstoffwechsel von PEMT-Knockout Mäusen", "en": "Abnormalities in lipid metabolism of PEMT knockout mice." }, "short": "PEMT-KO-Mäuse", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-12-17T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2023-04-30T02:00:00+02:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2021-12-20T09:49:08+01:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 4, "manager": 50712, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6852-50712-10" ] }, { "id": 8751, "title": { "de": "Neue Horizonte in der Behandlung von Pneumonie und Sepsis: Die Rolle von\r\nTRPC-Ionenkanälen bei bakteriellen Infektionen\r\n", "en": "New horizons in the treatment of pneumonia and sepsis: The role of\r\nTRPC ion channels in bacterial infections" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-04-01T02:00:00+02:00", "begin_effective": "2025-04-01T02:00:00+02:00", "end_planned": "2026-03-31T02:00:00+02:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2025-04-01T17:49:14+02:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 86144, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8751-86144-10" ] }, { "id": 9504, "title": { "de": "Datenerweiterung für die Aufrollung der österreichischen SARS-CoV-2-\r\nPandemie", "en": "Data expansion for the reappraisal of the Austrian SARS‑CoV‑2 pandemic" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-01-01T01:00:00+01:00", "begin_effective": "2026-01-01T01:00:00+01:00", "end_planned": "2026-03-31T02:00:00+02:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2025-12-17T16:11:40+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 125656, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9504-125656-10" ] }, { "id": 8140, "title": { "de": "Entschlüsselung von Alzheimer: \r\nTRPC1 als zentrale Figur bei Protein-Entfaltung und Cholesterin-Biosynthese\r\n", "en": "Deciphering Alzheimer's: \r\nTRPC1 as a central player in protein unfolding and cholesterol biosynthesis" }, "short": null, "url": null, "abstract": { "de": "Hintergrund: Die Alzheimer-Krankheit (AD) ist eine irreversible und tödliche Form von Demenz, unterteilt in sporadische (SAD) und familiäre AD (FAD). FAD, mit frühem Beginn aufgrund spezifischer Genmutationen, steht im Gegensatz zu SAD, das einen späten Beginn und eine unklare Ursache aufweist. Die Ca2+-Homöostase- Hypothese von SAD legt nahe, dass eine frühzeitige Ca2+-Dysregulation mit der Fehlfaltung von Proteinen und der Anreicherung von Cholesterin einhergeht. Das endoplasmatische Retikulum (ER) ist entscheidend für die Regulation des intrazellulären Ca2+, die Verarbeitung von Proteinen und die Lipid-Biosynthese. Die Familie der transienten Rezeptorpotenzial-Kanäle (TRPC1-7) umfasst TRPC1, der im Hippocampus stark exprimiert wird. Während TRPC2-7 ausschließlich in der Plasmamembran gefunden werden, befindet sich TRPC1 auch in der ER- Membran.\r\nHypothese: TRPC1 könnte an der Regulation von Ca2+, der Synthese von Proteinen und Cholesterin im ER beteiligt sein.\r\nErgebnisse: Vorläufige Experimente zeigten, dass TRPC1 den Ca2+-Leck aus dem ER signifikant verstärkte, den Cholesterinspiegel in TRPC1-transfizierten HEK293-Zellen erhöhte, den Cholesterinspiegel in den Hippocampi transgener Mäuse im Alter veränderte und die Expression von Transkriptionsfaktoren beeinflusste, die an der Proteinfaltung beteiligt sind.\r\nFazit: Eine weitere Erforschung der Rolle von TRPC1 im ER könnte ihn als potenzielles pharmazeutisches Ziel in der AD-Behandlung etablieren.", "en": "Background: Alzheimer’s disease (AD) is an irreversible and fatal form of dementia, divided into sporadic (SAD) and familial AD (FAD). FAD, with early onset due to specific gene mutations, contrasts SAD, with late onset and an unclear cause. The Ca2+ homeostasis hypothesis of SAD suggests early Ca2+ dyshomeostasis links to protein misfolding and cholesterol accumulation. The endoplasmic reticulum (ER) is crucial, managing intracellular Ca2+, protein processing, and lipid biosynthesis. The transient receptor potential canonical family (TRPC1-7) includes TRPC1, highly expressed in the hippocampus. While TRPC2-7 target the plasma membrane, TRPC1 is also found in the ER membrane.\r\nHypothesis: TRPC1 may be involved in Ca2+ handling, protein, and cholesterol synthesis in the ER.\r\nResults: Preliminary experiments showed TRPC1 increased Ca2+ leak from the ER, elevated cholesterol in TRPC1- transfected HEK293 cells, altered cholesterol levels in hippocampi from aged transgenic mice, and affected expression of transcription factors involved in protein folding.\r\nConclusion: Further exploring TRPC1 role in the ER could establish it as a potential pharmaceutical target in AD treatment." }, "begin_planned": "2024-03-01T01:00:00+01:00", "begin_effective": "2024-03-01T01:00:00+01:00", "end_planned": "2025-02-28T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2024-04-16T14:17:18+02:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 90337, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8140-90337-10", "8140-116421-12", "8140-122690-12" ] }, { "id": 6465, "title": { "de": "Polycystisches Ovar-Syndrom bei Adoleszenten und jungen Frauen-für eine pathophysiologie-basierte Behandlung", "en": "PCOS in adolescent girls and young women: toward a treatment guided by pathophysiology" }, "short": "SPIOMET4HEALTH ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-03-01T01:00:00+01:00", "begin_effective": "2021-04-01T02:00:00+02:00", "end_planned": "2026-02-28T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2021-02-22T12:29:25+01:00", "program": 109, "subprogram": null, "organization": 14091, "category": 10, "type": 10, "partner_function": 2, "manager": 50659, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "899671", "ethics_committee": null, "edudract_number": null, "persons": [ "6465-50659-10" ] }, { "id": 8106, "title": { "de": "Klonale Dominanz in Splicingfaktor mutierten myeloischen Neoplasien: Beitrag deregulierter Immunsignalwege", "en": "Aberrant immune signaling and clonal dominance in splicing factor mutant myeloid malignancies" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-03-01T01:00:00+01:00", "begin_effective": "2024-04-01T02:00:00+02:00", "end_planned": "2026-02-28T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2024-03-21T14:19:14+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 50747, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8106-50747-10", "8106-108881-12" ] }, { "id": 8478, "title": { "de": "Veränderung menschlicher Eosinophiler Granulozyten im Alter abhängig vom Geschlecht", "en": "Phenotypic changes of eosinophil granulocytes in aging and sex" }, "short": "Eosinph. Granulozyten_Alter_Geschlecht", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2025-09-30T02:00:00+02:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2024-11-06T09:30:06+01:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 85658, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8478-85658-10" ] }, { "id": 6587, "title": { "de": "Phänotypisierung und Mechanismen der humanen diabetischen Kardiomyopathie", "en": "Phenotyping and Candidate Mechanisms\r\nof Human Diabetic Cardiomyopathy" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-01-01T01:00:00+01:00", "begin_effective": "2021-01-01T01:00:00+01:00", "end_planned": "2022-12-31T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2021-05-19T12:48:52+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 100924, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 151 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6587-89639-12", "6587-101322-12", "6587-100924-10" ] }, { "id": 9081, "title": { "de": "Integrating exercise and NAD+ replenishment to reduce cardiometabolic risk\r\n", "en": "Integrating exercise and NAD+ replenishment to reduce cardiometabolic risk\r\n" }, "short": "iNterAcD+", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-04-01T02:00:00+02:00", "begin_effective": "2023-04-01T02:00:00+02:00", "end_planned": "2026-03-31T02:00:00+02:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2025-07-09T13:10:09+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 89979, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9081-89979-10", "9081-108473-12" ] }, { "id": 6029, "title": { "de": "Diagnostik und Management fieberhafter Erkrankungen unter Verwendung von personalisierter RNA Molekularsignatur ", "en": "Diagnosis and Management of Febrile Illness using RNA Personalised Molecular Signature Diagnosis" }, "short": "Diamonds", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-01-01T01:00:00+01:00", "begin_effective": "2020-01-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2020-01-17T15:19:36+01:00", "program": 109, "subprogram": null, "organization": 14091, "category": 10, "type": 10, "partner_function": 1, "manager": 51647, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": " 848196", "ethics_committee": null, "edudract_number": null, "persons": [ "6029-62056-12", "6029-51647-10" ] }, { "id": 5738, "title": { "de": "Expressionsmanipulation von osteoporose-assoziierter microRNAs in humanen Osteoblasten", "en": "Expression manipulation of osteoporosis-associated microRNAs in human MSC-derived osteoblasts " }, "short": "Neue Biomarker für die Osteoporose", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-05-01T02:00:00+02:00", "begin_effective": "2019-05-01T02:00:00+02:00", "end_planned": "2020-04-30T02:00:00+02:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2019-03-15T10:52:00+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 50909, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-43", "ethics_committee": null, "edudract_number": null, "persons": [ "5738-50909-10" ] }, { "id": 8739, "title": { "de": "Neue antimikrobielle, erdölfreie Oberflächen für\r\nKlinikbereich, Textilien und Verpackungen", "en": "New antimicrobial, petroleum-free surfaces for\r\nclinical areas, textiles and packaging" }, "short": "SafeSurface", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-03-01T01:00:00+01:00", "begin_effective": "2025-04-01T02:00:00+02:00", "end_planned": "2026-02-28T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2025-03-25T17:06:31+01:00", "program": 247, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 54018, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "FO999921649", "ethics_committee": null, "edudract_number": null, "persons": [ "8739-54018-10" ] }, { "id": 6820, "title": { "de": "enFaced 2.0 - AR-Tool für die Gesichtschirurgie", "en": "enFaced 2.0 - Instant AR Tool for Maxillofacial Surgery" }, "short": "enFaced 2.0", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-04-01T02:00:00+02:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2021-12-09T10:55:12+01:00", "program": 108, "subprogram": null, "organization": 14112, "category": 10, "type": 10, "partner_function": 2, "manager": 76910, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI1044", "ethics_committee": null, "edudract_number": null, "persons": [ "6820-76910-10" ] }, { "id": 8825, "title": { "de": "Kardiovaskuläre Auswirkungen bei Neugeborenen von Müttern\r\nmit Schwangerschaftsdiabetes\r\n", "en": "Cardiovascular effects in neonates of mothers\r\nwith gestational diabetes" }, "short": "Kardiovask_Auswirk_SchwangerschDiabetes", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2026-03-31T02:00:00+02:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2025-05-05T12:08:47+02:00", "program": null, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 50674, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8825-50674-10" ] }, { "id": 8055, "title": { "de": "Manipulation des intra- und extrazellulären K+ in Krebs", "en": "Targeting K+ in cancer" }, "short": "Targeting K+ in cancer", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-06-01T02:00:00+02:00", "begin_effective": "2021-09-01T02:00:00+02:00", "end_planned": "2022-06-01T02:00:00+02:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2024-02-21T15:16:05+01:00", "program": 69, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 92462, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "J4457", "ethics_committee": null, "edudract_number": null, "persons": [ "8055-92462-10", "8055-130318-12", "8055-130657-12", "8055-132497-12" ] } ] }