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GET /v1/research/project/?format=api&offset=360&ordering=-begin_effective
{ "count": 2244, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=380&ordering=-begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=340&ordering=-begin_effective", "results": [ { "id": 7645, "title": { "de": "Charakterisierung von P2Y-Rezeptoren in T-Zell-Subtypen: Eine Möglichkeit zur Wiederherstellung einer gesunden Immunfunktion bei älteren Menschen?", "en": "Characterization of P2Y receptors in T cell subsets: A tool to restore healthy immune function in the elderly?" }, "short": "P2Y receptors on T cells in the elderly", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-07-01T02:00:00+02:00", "begin_effective": "2023-08-01T02:00:00+02:00", "end_planned": "2023-07-31T02:00:00+02:00", "end_effective": "2024-07-31T02:00:00+02:00", "assignment": "2023-07-03T16:30:15+02:00", "program": null, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": 95212, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7645-95212-10" ] }, { "id": 7651, "title": { "de": "Neutrophile und GPR55: neue Mitspieler bei Eosinophiler Ösophagitis ", "en": "Neutrophils and GPR55: new players in Eosinophilic Esophagitis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-08-01T02:00:00+02:00", "begin_effective": "2023-08-01T02:00:00+02:00", "end_planned": "2024-08-01T02:00:00+02:00", "end_effective": "2024-08-01T02:00:00+02:00", "assignment": "2023-07-04T13:08:26+02:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 97983, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7651-97983-10" ] }, { "id": 7698, "title": { "de": "Erforschung eines mechanistischen Stoffwechselweges, welcher ein potentieller Auslöser für IUGR ist.", "en": "Investigation of a mechanistic metabolic pathway, potentially contributing IUGR " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-09-01T02:00:00+02:00", "begin_effective": "2023-08-01T02:00:00+02:00", "end_planned": "2024-11-01T01:00:00+01:00", "end_effective": "2024-10-01T02:00:00+02:00", "assignment": "2023-07-28T13:06:02+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 82600, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7698-82600-10" ] }, { "id": 7654, "title": { "de": "Die Rolle des Prostaglandin D2 Rezeptor 2 in der Tumor-Mikroumgebung des Dickdarmkarzinoms", "en": "The role of prostaglandin D2 receptor 2 in the tumor microenvironment of colon cancer" }, "short": "Prostaglandin D2 Rezeptor_Dickdarmkarzin", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-08-01T02:00:00+02:00", "begin_effective": "2023-08-01T02:00:00+02:00", "end_planned": "2024-07-31T02:00:00+02:00", "end_effective": "2024-07-31T02:00:00+02:00", "assignment": "2023-07-04T15:23:03+02:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 99558, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7654-99558-10" ] }, { "id": 8049, "title": { "de": "Verbesserung der Achtsamkeit für Mentalen Gesundheit bei Studenten in Kenya", "en": "Strengthening Mental Health Awareness among Secondary School Students in\r\nKenya (SMEHAS)" }, "short": "SMEHAS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-08-11T02:00:00+02:00", "begin_effective": "2023-07-01T02:00:00+02:00", "end_planned": "2025-08-11T02:00:00+02:00", "end_effective": "2025-06-30T02:00:00+02:00", "assignment": "2024-02-20T14:35:55+01:00", "program": 201, "subprogram": null, "organization": 29447, "category": 10, "type": 10, "partner_function": 2, "manager": 59288, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8049-59288-10" ] }, { "id": 7795, "title": { "de": "Entwicklung und biologische Charakterisierung eines nanoskaligen Wirkstoffdarreichungssystems für den einbau von multiresistenzumgehenden RNA Konstrukten", "en": "Development and biological characterization of nanoscale drug delivery systems, incorporating multidrug resistence-reversing RNA constructs" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-07-01T02:00:00+02:00", "begin_effective": "2023-07-01T02:00:00+02:00", "end_planned": "2025-06-30T02:00:00+02:00", "end_effective": "2025-09-30T02:00:00+02:00", "assignment": "2023-10-03T13:43:33+02:00", "program": 207, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 113130, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7795-113130-10" ] }, { "id": 7774, "title": { "de": "Die Inzidenz der Hyperfibrinolyse während natürlicher Geburt und Sectio caesarea", "en": "The incidence of hyperfibrinolysis during vaginal delivery and cesarean section " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-06-01T02:00:00+02:00", "begin_effective": "2023-07-01T02:00:00+02:00", "end_planned": "2023-11-30T01:00:00+01:00", "end_effective": "2024-03-31T01:00:00+01:00", "assignment": "2023-09-19T17:12:41+02:00", "program": null, "subprogram": null, "organization": 14069, "category": 10, "type": 10, "partner_function": 4, "manager": 60097, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": "GZ: FIF-A 16-0361/2023-0001 CRM:0055218", "ethics_committee": null, "edudract_number": null, "persons": [ "7774-58422-11", "7774-60097-10" ] }, { "id": 7619, "title": { "de": "Umfassende genetische Analyse von Patienten und Patientinnen mit Auftreten einer Krebserkrankung in jüngerem Alter", "en": "Comprehensive genetic analysis of patients with onset of cancer at a younger age" }, "short": "CotY", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-05-01T02:00:00+02:00", "begin_effective": "2023-07-01T02:00:00+02:00", "end_planned": "2025-04-30T02:00:00+02:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2023-06-16T10:50:35+02:00", "program": null, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 4, "manager": 57423, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 52 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7619-57423-10" ] }, { "id": 7306, "title": { "de": "KCNRG in der Regulation der Lungenzirkulation", "en": "Novel role of the potassium channel regulator KCNRG in the pulmonary circulation" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-07-01T02:00:00+02:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2027-06-30T02:00:00+02:00", "assignment": "2022-12-19T11:45:25+01:00", "program": 111, "subprogram": null, "organization": 14006, "category": 10, "type": 10, "partner_function": 4, "manager": 54345, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I 6299", "ethics_committee": null, "edudract_number": null, "persons": [ "7306-62906-12", "7306-84366-12", "7306-91409-12", "7306-102187-12", "7306-110870-12", "7306-54345-10" ] }, { "id": 7529, "title": { "de": "Impfbare Krankheiten bei schwangeren und stillenden Frauen", "en": "Vaccine preventable diseases in pregnant and lactating women" }, "short": null, "url": null, "abstract": { "de": "Given its effectiveness in protecting pregnant women, foetuses and infants from infectious diseases, maternal immunization has gained interest in recent years. Nevertheless, information on the optimal timing for this vaccination strategy is limited by the relatively poor understanding of the immunobiology of vaccine responses in pregnancy and during lactation. Dynamic changes in immune function occur during gestation that may affect vaccine response in pregnant women if vaccination is given at a different timepoint in pregnancy. Additionally, since several recommendations for vaccination in pregnancy or during lactation are currently in place or being made, the question arises whether the administration of different vaccines has an impact on the induction of the antibody-mediated immune responses and whether this possibly also influence the kinetics of these vaccine-induced antibodies. This implies that repeated sampling after vaccination is needed to describe and analyse antibody kinetics. However, the design of maternal immunization studies is typically informed by generic statistical approaches not dealing with questions as to when and how often samples should be taken in order to gather the right amount of information to investigate antibody kinetics.\r\n\r\nThe objectives are 1) to describe and compare kinetics of antibodies to two different vaccines (Tdap, COVID-19) and to investigate potential interactions; 2) to develop a framework to plan maternal immunization studies.\r\n\r\nIn two ongoing trials, serum and breastmilk samples are collected at several timepoints during and after pregnancy. In the Tdap trial, three cohorts of women are included differing in gestational age at which women are vaccinated with Tdap vaccine. In the COVID-19 trial, the effects of vaccinating pregnant and lactating women with a COVID-19 vaccine are investigated. In this project, we will measure antibody titres in blood and breastmilk samples for the vaccine not being the focus of the respective trial, i.e. getting in all samples information on Tdap and COVID-19. We will use mathematical models combined with statistical tools to analyse dynamic immune response and to improve the design of maternal immunization studies.\r\n\r\nThe main innovations are:1) comparing kinetic behaviour of antibodies induced by two different vaccines on several time points in serum and breastmilk; 2) investigating potential interactions of antibodies induced by two vaccines impacting the kinetics over time; 3) development of novel methodology to analyse and plan maternal immunization studies. Within this project, we focus on pertussis and COVID-19 as examples, but outcomes of this project can be applied to other infectious diseases for which vaccines can be administered in pregnancy or during lactation.", "en": "Aufgrund der hohen Anfälligkeit von Schwangeren, Föten und Säuglingen für Infektionskrankheiten hat die Immunisierung von Müttern in den letzten Jahren an Interesse gewonnen. Dennoch ist der optimale Zeitpunkt für eine Impfung in der Schwangerschaft noch immer unbekannt. Außerdem kommt es während der Schwangerschaft zu dynamischen Veränderungen der Immunfunktion, wenn ein Impfstoff zu einem anderen Schwangerschaftsalter verabreicht wird. Dies kann die Reaktion auf den Impfstoff und die Kinetik der durch den Impfstoff induzierten mütterlichen Antikörper im Blut und in der Muttermilch der Schwangeren beeinflussen.\r\n\r\nDa derzeit mehrere Empfehlungen für Impfungen in der Schwangerschaft gelten bzw. ausgesprochen werden, stellt sich außerdem die Frage, ob die Verabreichung verschiedener Impfstoffe in der Schwangerschaft Auswirkungen auf die Immunreaktionen auf diese Impfstoffe hat und möglicherweise eine Wechselwirkung in der Kinetik der durch verschiedene Impfstoffe induzierten Antikörper verursacht.\r\n\r\nIm Rahmen dieses Projekts wollen wir den optimalen Zeitpunkt für die Impfung in der Schwangerschaft bestimmen, die Antikörperkinetik vergleichen und mögliche Wechselwirkungen bei der Immunantwort untersuchen, wenn verschiedene Impfstoffe (z. B. Pertussis, COVID-19) in der Schwangerschaft verabreicht werden. Wir entwickeln konzeptionelle Rahmen, in denen wir statistische Ansätze mit mathematischen Modellen von Infektionskrankheiten kombinieren, um die Analyse und das Design von Studien zur mütterlichen Immunisierung zu verbessern.\r\n\r\nDer Schwerpunkt des Projekts liegt auf Pertussis und COVID-19, aber die Ergebnisse können auch auf andere Infektionskrankheiten angewendet werden, gegen die Impfstoffe in der Schwangerschaft verabreicht werden können." }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-06-01T02:00:00+02:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2028-05-31T02:00:00+02:00", "assignment": "2023-04-27T14:12:52+02:00", "program": 111, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 1, "manager": 83644, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I6376", "ethics_committee": null, "edudract_number": null, "persons": [ "7529-83644-10" ] }, { "id": 7461, "title": { "de": "ActiHeal: Rolle des ribosomalen Proteins S6 in der Heilung", "en": "ActiHeal: role of ribosomal protein S6 in healing" }, "short": "ActiHeal", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-06-01T02:00:00+02:00", "begin_effective": "2023-06-01T02:00:00+02:00", "end_planned": "2025-05-31T02:00:00+02:00", "end_effective": "2027-03-31T02:00:00+02:00", "assignment": "2023-03-27T14:38:06+02:00", "program": 72, "subprogram": null, "organization": 14076, "category": 10, "type": 10, "partner_function": 2, "manager": 80111, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 36483", "ethics_committee": null, "edudract_number": null, "persons": [ "7461-80111-10" ] }, { "id": 7552, "title": { "de": "Früherkennung von Therapieresistenzen bei Prostatakrebs: RNA-analysen von therapierelevanten Biomarkern in zirkulierenden Tumorzellen", "en": "Early detection of therapy resistance in prostate cancer: RNA analysis of therapy-relevant biomarkers in circulating tumor cells" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-04-01T02:00:00+02:00", "begin_effective": "2023-06-01T02:00:00+02:00", "end_planned": "2024-04-30T02:00:00+02:00", "end_effective": "2025-06-30T02:00:00+02:00", "assignment": "2023-05-10T12:09:21+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 66435, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1888 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7552-66435-10", "7552-105102-12" ] }, { "id": 7612, "title": { "de": "Kombination von \"secondary bioinformatics\" und \"spatial transcriptomics\" zur Analyse des größten Datensets von Transkriptomdaten der humanen Placenta im Verlauf der Schwangerschaft und bei Präeklampsie", "en": "Combining secondary bioinformatics and spatial transcriptomics to analyze the largest data set of transcriptome data of the human placenta in the course of normal pregnancy and in preeclampsia" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-06-01T02:00:00+02:00", "begin_effective": "2023-06-01T02:00:00+02:00", "end_planned": "2025-05-31T02:00:00+02:00", "end_effective": "2025-05-31T02:00:00+02:00", "assignment": "2023-06-12T13:52:14+02:00", "program": 207, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 1, "manager": 54142, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7612-54142-10" ] }, { "id": 8087, "title": { "de": "Die Bedeutung der Lipidhydrolyse für die Regeneration der Lunge nach bakterieller\r\nLungenentzündung.", "en": "Importance of lipid hydrolysis for lung regeneration after bacterial\r\npneumonia." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-06-01T02:00:00+02:00", "begin_effective": "2023-06-01T02:00:00+02:00", "end_planned": "2023-06-01T02:00:00+02:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2024-03-15T09:14:48+01:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 65966, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8087-65966-10" ] }, { "id": 7627, "title": { "de": "Tissue©ell", "en": "Tissue©ell" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-06-01T02:00:00+02:00", "begin_effective": "2023-06-01T02:00:00+02:00", "end_planned": "2024-01-31T01:00:00+01:00", "end_effective": "2024-01-31T01:00:00+01:00", "assignment": "2023-06-20T17:34:23+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1310 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 7658, "title": { "de": "Mechanistic Studies of the Vascular and Cardiac Effects of the Aqueous Calyx Extract of Hibiscus sabdariffa ", "en": "Mechanistic Studies of the Vascular and Cardiac Effects of the Aqueous Calyx Extract of Hibiscus sabdariffa " }, "short": "AQUECALYX", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-06-01T02:00:00+02:00", "begin_effective": "2023-06-01T02:00:00+02:00", "end_planned": "2025-05-31T02:00:00+02:00", "end_effective": "2025-11-30T01:00:00+01:00", "assignment": "2023-07-06T11:49:58+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 2, "manager": 57932, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7658-57932-10" ] }, { "id": 7757, "title": { "de": "ROBo(o)st- VoRn dabei beim Forschen", "en": "ROBo(o)st- VoRn dabei beim Forschen" }, "short": "ROBoost", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-06-01T02:00:00+02:00", "begin_effective": "2023-06-01T02:00:00+02:00", "end_planned": "2025-05-31T02:00:00+02:00", "end_effective": "2025-05-31T02:00:00+02:00", "assignment": "2023-09-12T15:20:25+02:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 3, "manager": 50654, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "FO999900572", "ethics_committee": null, "edudract_number": null, "persons": [ "7757-50654-10" ] }, { "id": 7646, "title": { "de": "Pilotprojekt DigiDiab Assistenz Mobile Pflege", "en": "Pilot DigiDiab Assistant Domiciliary Nursing Care" }, "short": "DigiDiab", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-12-01T01:00:00+01:00", "begin_effective": "2023-06-01T02:00:00+02:00", "end_planned": "2024-11-30T01:00:00+01:00", "end_effective": "2025-08-31T02:00:00+02:00", "assignment": "2023-07-03T17:39:49+02:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 3, "manager": 65558, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2160 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7646-54235-12", "7646-65558-10", "7646-99971-12" ] }, { "id": 7672, "title": { "de": "Nachhaltige und grüne Elektronik in der Kreislaufwirtschaft", "en": "Sustainable and green electronics for circular economy" }, "short": "SUSTRONICS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-06-01T02:00:00+02:00", "begin_effective": "2023-06-01T02:00:00+02:00", "end_planned": "2026-05-31T02:00:00+02:00", "end_effective": "2026-05-31T02:00:00+02:00", "assignment": "2023-07-10T11:21:51+02:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51809, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10, 416 ], "funder_projectcode": "101112109 und FO999899269", "ethics_committee": null, "edudract_number": null, "persons": [ "7672-98005-12", "7672-51809-10", "7672-104611-12" ] }, { "id": 7490, "title": { "de": "NR4A1 mediierte Regulation der Immuneevasion in Lymphomen", "en": "NR4A1-mediated regulation of immune evasion in lymphoma*" }, "short": "NIEL", "url": null, "abstract": { "de": "Tumorzellen haben eine Reihe von Mechanismen entwickelt, um die immunvermittelte Erkennung und Zerstörung von Tumorzellen zu umgehen bzw. zu unterdrücken. Eine unserer Erkenntnisse ist, dass ein Teil der aggressiven B-Lymphome, maligne Tumore der antikörperproduzierenden Zellen, eine geringe Expression des Transkriptionsfaktors NR4A1 aufweisen. NR4A1 reguliert, wie andere Transkriptionsfaktoren, zahlreiche biologische Prozesse in Zellen. Die Funktion in aggressiven B-Lymphomen ist jedoch bis dato noch nicht untersucht worden. In unserer Vorstudie haben wir herausgefunden, dass eine niedrige NR4A1-Expression mit einer reduzierten Überlebensrate bei Standardtherapie einherging. In unserem Lymphommausmodell konnten wir nachweisen, dass der Verlust von Nr4a1 die Lymphomentwicklung deutlich beschleunigte, begleitet von einer erhöhten Expression immunsuppressiver Oberflächenmoleküle und einem höheren Gehalt an Immunzellen in Mäusen, die ein funktionierendes Immunsystem besaßen, aber nicht in Mausmodellen mit einem nicht funktionierenden Immunsystem. Weitere Analysen deuten darauf hin, dass der Verlust von Nr4a1 mit einer verminderten immunzellvermittelten Zerstörung von Lymphomzellen verbunden ist. Zusammenfassend deuten unsere Daten auf eine tumorsuppressive Funktion von NR4A1 hin, die durch immunregulatorische Eigenschaften bei der Entwicklung aggressiver Lymphome vermittelt wird.\r\nIn dem geplanten Projekt wollen wir mit globalen genetischen Ansätzen aufklären, welche Gene und/oder genetischen Programme durch NR4A1 reguliert werden, sowie mit Hilfe neuartiger Sequenzierungstechnologien die Auswirkungen von NR4A1 auf die Zusammensetzung und die Aktivität der Immunzellen in aggressiven Lymphomen untersuchen. Darüber hinaus wollen wir die Wirksamkeit von Immuntherapien als Einzelwirkstoffe sowie in Kombination (einschließlich neuer Moleküle) in Bezug auf die NR4A1-Expression bei aggressiven Lymphomen funktionell testen. Schließlich werden wir die Daten aus dem präklinischen Modell auf Patientenproben übertragen. Hier werden wir NR4A1, Antigenpräsentation und immunsuppressive Oberflächenmoleküle in unserer DLBCL-Patientenkohorte untersuchen, um unsere Erkenntnisse in einem klinischeren Umfeld zu validieren.\r\nAnhand der Ergebnisse könnten wir einen neuen Mechanismus identifizieren, der wesentlich zur Lymphomentwicklung beiträgt und zur Identifizierung von Lymphompatienten genutzt werden kann, die von einer neuartigen Immuntherapie profitieren könnten.\r\n", "en": "Tumour cells have developed a number of mechanisms to avoid or suppress their recognition, targeting and killing by immune cells. We found out that a part of aggressive B cell lymphomas, a tumour consisting of the antibody-producing cells, exhibited low expression of the transcription factor NR4A1. NR4A1, like other transcription factors, regulates numerous biological processes in cells. However, its function has not been yet investigated in aggressive B cell lymphomas. In our preliminary study, we observed that low NR4A1 levelwas associated with reduced survival in patients treated with standard therapy. In mice with a functional immune system, we showed that loss of Nr4a1 markedly accelerated the development of lymphoma, with increased presence of surface molecules that inhibit immune cells, but also a higher content of these immune cells compared to immunodeficient mouse models. Further, our analyses indicate that loss of Nr4a1 is linked to reduced killing of lymphoma by immune cells. Taken together our data indicate a tumour-suppressive function of NR4A1 mediated by its immune regulatory properties in the development of aggressive lymphomas.\r\nIn the planned project, we aim to elucidate which genes and/or genetic programs are regulated by NR4A1 with global genetic approaches and to investigate the impact of NR4A1 on immune cell composition and activity in aggressive lymphomas using novel sequencing technologies. In addition, our aim is to functionally test the efficacy of immune therapies as single agents as well as in combination (including novel molecules) in relation to the NR4A1 level in aggressive lymphomas. Finally, we will transfer data from the preclinical model to patients samples and investigate NR4A1 expression, antigen presentation, and immune suppressive surface molecules in our DLBCL patient cohort to validate our findings in a more clinical setting.\r\nBased on the finding, we might identify a novel mechanism, which significantly contribute to lymphoma development and which can be used to identify lymphoma patients who may benefit from a novel type of immune therapy. \r\n" }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-05-15T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-10-14T02:00:00+02:00", "assignment": "2023-04-11T15:10:20+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 59183, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P36643", "ethics_committee": null, "edudract_number": null, "persons": [ "7490-100134-12", "7490-59183-10", "7490-79614-12", "7490-82501-12", "7490-85928-12", "7490-92181-12", "7490-111069-12", "7490-130555-12", "7490-131900-12", "7490-122350-12", "7490-122590-12" ] } ] }