Project List
List projects.
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The following relational fields can be expanded:
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begin_planned:gt,gte,lt,ltebegin_effective:gt,gte,lt,lteend_planned:gt,gte,lt,lteend_effective:gt,gte,lt,lte
GET /v1/research/project/?format=api&offset=340&ordering=-end_planned
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=360&ordering=-end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=320&ordering=-end_planned", "results": [ { "id": 8707, "title": { "de": "Pilotprojekt: 5 Präventionsfaktoren der Grazer Gehirngesundheit", "en": "Pilot project: 5 Preventive Factors of brain health" }, "short": "5P_3G", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-27T01:00:00+01:00", "begin_effective": "2025-01-27T01:00:00+01:00", "end_planned": "2026-01-27T01:00:00+01:00", "end_effective": "2026-03-04T01:00:00+01:00", "assignment": "2025-03-04T18:18:04+01:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 66708, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8707-66708-10" ] }, { "id": 7553, "title": { "de": "Zusammensetzung und Funktion von Immunzellen bei Patient*innen mit und ohne Steroid-refraktärer akuter Graft-versus-Host-Erkrankung nach allogener hämatopoetischer Blutzelltransplantation", "en": "Immune cell composition and function in patients with and without steroid-refractory acute graft-versus-host disease after allogeneic hematopoietic cell transplantation" }, "short": "Prospektives GVHD Projekt", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-12T01:00:00+01:00", "begin_effective": "2023-05-01T02:00:00+02:00", "end_planned": "2026-01-12T01:00:00+01:00", "end_effective": "2026-04-30T02:00:00+02:00", "assignment": "2023-05-10T12:09:34+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 1, "manager": 82501, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7553-100134-12", "7553-59183-12", "7553-82501-10", "7553-111069-12" ] }, { "id": 8929, "title": { "de": "Anatomisches Erbe: Unseren Vergangenheit digital bewahren, Unsere Zukunft sichern", "en": "ANATOMICAL LEGACY: DIGITALLY PRESERVING OUR PAST, SECURING OUR FUTURE" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-04-01T02:00:00+02:00", "begin_effective": "2025-06-01T02:00:00+02:00", "end_planned": "2026-01-12T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2025-05-23T11:40:55+02:00", "program": 207, "subprogram": null, "organization": 14018, "category": 10, "type": 10, "partner_function": 1, "manager": 102804, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8929-97024-12", "8929-102804-10" ] }, { "id": 7284, "title": { "de": "Tissue-Faktor-Aktivierung durch Gallensäuren in Hepatozyten *Wiedereinreichung", "en": "Bile acid-mediated tissue factor activation in hepatocytes *resubmission" }, "short": null, "url": "https://allgemeine-paediatrie.medunigraz.at/forschung/paediatrische-haemostaseologie/tissue-faktor-aktivierung-durch-gallensaeuren-in-hepatozyten", "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-07T01:00:00+01:00", "begin_effective": "2023-10-01T02:00:00+02:00", "end_planned": "2026-01-06T01:00:00+01:00", "end_effective": "2026-09-30T02:00:00+02:00", "assignment": "2022-12-02T11:34:30+01:00", "program": 72, "subprogram": null, "organization": 14091, "category": 10, "type": 10, "partner_function": 4, "manager": 62201, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P36569", "ethics_committee": null, "edudract_number": null, "persons": [ "7284-62201-10", "7284-101463-12", "7284-116323-12", "7284-117943-12" ] }, { "id": 8188, "title": { "de": "Pilztranslokation über den Darm gemessen durch 1,3-Beta-D-Glukan und seine Rolle in Patient:innen mit Leberzirrhose", "en": "Gut fungal translocation measured by 1,3-Beta-D-Glucan and its role in patients with liver cirrhosis" }, "short": "BDG-Cirrhosis", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-08-01T02:00:00+02:00", "begin_effective": "2024-08-01T02:00:00+02:00", "end_planned": "2026-01-01T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-05-07T15:35:19+02:00", "program": null, "subprogram": null, "organization": 29164, "category": 10, "type": 10, "partner_function": 4, "manager": 115781, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 203 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8188-115781-10" ] }, { "id": 8541, "title": { "de": "Der Einfluss von Adipsin auf den Phänotyp von Lungenfibroblasten", "en": "The influence of adipsin in lung fibroblasts phenotype" }, "short": "Adipsin_Phänotyp_Lungenfibroblasten", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-01-01T01:00:00+01:00", "end_effective": "2026-01-01T01:00:00+01:00", "assignment": "2024-12-04T12:08:02+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 73404, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8541-73404-10" ] }, { "id": 8317, "title": { "de": "Neurofilamente im Kammerwasser von Glaukompatient*innen", "en": "Neurofilaments in the Aqueous Humor of Glaucoma Patients" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2024-09-01T02:00:00+02:00", "end_planned": "2026-01-01T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-07-31T14:56:00+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": 89577, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 938 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8317-89577-10" ] }, { "id": 8633, "title": { "de": "Messung der bukkalen Knochen- und Mukosadicke mittels Ultraschall und künstlicher Intelligenz in der dentalen Implantologie", "en": "Ultrasound assessment of buccal bone and mucosal thickness using artificial intelligence aided segmentation in dental implantology" }, "short": "Ultimate-Project", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-05-01T02:00:00+02:00", "begin_effective": "2023-05-01T02:00:00+02:00", "end_planned": "2026-01-01T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2025-01-31T15:35:22+01:00", "program": null, "subprogram": null, "organization": 14111, "category": 10, "type": 10, "partner_function": 4, "manager": 125157, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 35 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8633-125157-10" ] }, { "id": 7906, "title": { "de": "INTERACT-EUROPE 100", "en": "INTERACT-EUROPE 100" }, "short": "INTERACT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2023-12-01T01:00:00+01:00", "end_planned": "2026-01-01T01:00:00+01:00", "end_effective": "2026-11-30T01:00:00+01:00", "assignment": "2023-11-28T13:37:15+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 107132, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101129375", "ethics_committee": null, "edudract_number": null, "persons": [ "7906-107132-10" ] }, { "id": 8151, "title": { "de": "Das intestinale Mikrobiom eines orthotopen und eines ektopen Hepatoblastom Mausmodelles", "en": "The Intestinal Microbiome in an Orthotopic and Ectopic Tumor Murine Model of Hepatoblastoma" }, "short": "Microbiome in Hepatoblastoma Mouse Model", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2024-04-24T15:59:17+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 1, "manager": 90375, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8151-50778-12", "8151-90375-10", "8151-97866-12" ] }, { "id": 7916, "title": { "de": "ARCTECH: Das Potenzial von Archaea nutzbar machen\r\nAusbildung der nächsten Visionäre Europas für eine innovative und nachhaltige Zukunft", "en": "ARCTECH: Harnessing the potential of Archaea\r\nTraining Europe’s next visionaries for an innovative and sustainable future" }, "short": "ARCTECH", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2024-03-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2028-02-29T01:00:00+01:00", "assignment": "2023-12-07T10:05:45+01:00", "program": 209, "subprogram": "HORIZON-MSCA-2022-DN-01", "organization": 14023, "category": 10, "type": 10, "partner_function": 2, "manager": 90021, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101120407", "ethics_committee": null, "edudract_number": null, "persons": [ "7916-90021-10", "7916-99612-12", "7916-100035-12", "7916-104024-12", "7916-109121-12", "7916-100806-12", "7916-106195-12", "7916-128134-12" ] }, { "id": 8144, "title": { "de": "Metabolische Signaturen von T-Zell-Untergruppen als neue diagnostische oder therapeutische Angriffspunkte bei Kollagenose-assoziierten interstitiellen Lungenerkrankungen", "en": "Metabolic signatures of T cell subsets as novel diagnostic or therapeutic\r\ntargets in connective tissue disease-associated interstitial lung disease" }, "short": "T cell metabolism in CTD-ILD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-04-23T17:42:43+02:00", "program": null, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 3, "manager": 95212, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8144-78952-11", "8144-95212-10", "8144-107391-11" ] }, { "id": 7155, "title": { "de": "Hypermethylierung als Resistenzmechanismus für eine cisplatinhältige Chemotherapie bei Keimzelltumorpatienten", "en": "Hypermethylation as a mechanism for cisplatin resistance in germ cell tumors" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2022-09-02T10:19:44+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 86226, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1375 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7155-86226-10" ] }, { "id": 8316, "title": { "de": "Uterine Trophoblasteninvasion: Ein mastrixbasiertes 3D-Gefäßmodel zur \r\nCharakterisierung schwangerschaftsassozierter Erkrankungen", "en": "Uterine trophoblast invasion: A mastrix-based 3D vascular model for the characterization of pregnancy-associated diseases" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-07-29T15:26:52+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 76930, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8316-76930-10", "8316-97931-11" ] }, { "id": 8294, "title": { "de": "Der Zusammenhang zwischen Körpergewicht und kortikaler Neuroplastizität und Lernen – eine Pilotstudie", "en": "The relationship between Body Weight and Human Motor Cortical Plasticity and Learning" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-04-30T02:00:00+02:00", "assignment": "2024-07-10T16:17:43+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 58643, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": "FIF-A 16-0532/2024-0001", "ethics_committee": null, "edudract_number": null, "persons": [ "8294-58643-10" ] }, { "id": 7896, "title": { "de": "Verbesserung der MALDI-TOF-Identifizierung von Pseudomonas-Arten: Ein Schritt zur schnellen und genauen Untersuchung", "en": "Improvement of MALDI-TOF identification of Pseudomonas species: A step towards fast and accurate investigation of antimicrobial susceptibility " }, "short": null, "url": null, "abstract": { "de": "Pseudomonas ist weit verbreitet, insbesondere in aquatischen Umgebungen, und kann dort unter verschiedenen Bedingungen gut überleben. Pseudomonas kann Infektionen bei Menschen, Tieren und Pflanzen verursachen. Die hohe natürliche Antibiotikaresistenz stellt ein besonderes Problem in der Humanmedizin dar. In den letzten Jahren hat die Anzahl der Arten aus dem Genus ebenfalls erheblich zugenommen, und Studien deuten darauf hin, dass viele Arten noch zu beschreiben sind. Um die Bedeutung dieser verschiedenen Arten für die Umwelt, aber auch für den Menschen zu verstehen, ist eine gute und einfache Unterscheidung der einzelnen Arten erforderlich.\r\n\r\nDie Zusammenarbeit zwischen ANSES und MUG wird die MALDI-TOF-Differenzierung und eine offene Datenbank nutzen, um eine Methode zur schnellen, kostengünstigen und zuverlässigen Bestimmung von Pseudomonas-Arten zu entwickeln. Die Stammsammlungen der beiden Institutionen dienen als Grundlage. Diese umfassen Isolate aus der Umwelt sowie aus humanen und veterinären Proben. Die Isolate sollen durch Sequenzierung und MALDI-TOF charakterisiert werden. Die Resistenz gegenüber wichtigen Antibiotika wird ebenfalls an diesen Isolaten mit beiden Methoden, Agardiffusion und Mikrodilution, getestet.\r\n\r\nDie MALDI-TOF-Proben werden in einer frei zugänglichen Datenbank platziert. Diese Anwendung wird kostenlos sein und von jedermann genutzt werden können. Ein weiterer Vorteil wird sein, dass man mit der Anwendung in Kontakt mit anderen Forschern kommen kann, die an Pseudomonas arbeiten, und so ein Pseudomonas-Netzwerk aufgebaut werden könnte. Wenn dieses Projekt erfolgreich ist, könnte es auch auf andere Bakteriengruppen (z. B. Aeromonas, Bacilli usw.) angewendet werden. In jedem Fall legt diese Arbeit den Grundstein für eine enge Zusammenarbeit zwischen ANSES und MUG auf dem Gebiet der Pseudomonadenforschung.", "en": "Pseudomonas that is widespread, especially in aquatic environments, and can survive well there under various conditions. Pseudomonas can cause infections in humans, animals and plants. The high natural resistance to antibiotics is a particular problem in human medicine. In recent years, the number of species from the genus has also increased considerably and studies suggest that many species remain to be described. To understand the importance of these different species for the environment but also for humans, a good and simple differentiation of the individual species is necessary.\r\nThe collaboration between ANSES and MUG will use MALDI TOF differentiation and an open database to develop a method for fast, cheap and reliable determination of species of Pseudomonas.\r\nStrain collections of the two institutions serve as a basis. These include isolates from the environment, from human and veterinary samples. The isolates are to be chartered by sequencing and MALDI TOF. Resistance to important antibiotics will also be tested in these isolates using btoh methods Agar diffusion and Micro broth dilution. MALDI TOF specimens will be placed in a open accessible database. This application will be free of charge and can be used by anyone. Another advantage will be that with the application one can get in touch with other researchers working on Pseudomonas and thus a Pseudomonas network could be established\r\nIf this project proves successful, it could also be applied to other groups of bacteria (e.g. Aeromonas, Bacilli, etc.). In any case, this work lays the foundation for close collaboration between ANSES and MUG in the field of Pseudomonads research. The participating institutions in France and Austria have different and complementary expertise in the research of this genus. A harmonisation and an efficient exchange of methods will be a key factor for both, to deepen their standing in this field of research and to other aquatic genera like Vibrio, Aeromonas.\r\n" }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2023-11-21T15:29:59+01:00", "program": 207, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 58733, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "FR 01/2024", "ethics_committee": null, "edudract_number": null, "persons": [ "7896-54018-12", "7896-58733-10", "7896-103077-12" ] }, { "id": 8024, "title": { "de": "Interaktionen von Kaffeesäure mit Nanocellulose", "en": "Interactions of caffeic acid with nanocellulose" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-02-05T15:17:40+01:00", "program": 207, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 113130, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8024-113130-10" ] }, { "id": 8752, "title": { "de": "Aufbau der Grazer Ambulanz für Riech- und Schmeckstörungen", "en": "Establishment of the Graz Clinic for Smell and Taste Disorders" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-06-01T02:00:00+02:00", "begin_effective": "2025-05-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2025-04-01T19:13:16+02:00", "program": null, "subprogram": null, "organization": 14066, "category": 10, "type": 10, "partner_function": 4, "manager": 89704, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": "FIF-A 16-0020/2025-0001", "ethics_committee": null, "edudract_number": null, "persons": [ "8752-89704-10" ] }, { "id": 7363, "title": { "de": "Digitale Zwillinge für die Behandlung von Vorhofflimmern", "en": "Digital Twins to Treat Atrial Fibrillation" }, "short": "DAWN-AF", "url": null, "abstract": { "de": "Vorhofflimmern (VHF) ist die häufigste Arrhythmie des Herzens. Bei VHF handelt es sich um eine fortschreitende Erkrankung des Herzens. Je länger VHF andauert, umso schwieriger ist die Behandlung, und das Risiko Folgeschäden wie Schlaganfälle, Demenz oder Herzinsuffizienz zu erleiden nimmt zu. Die effektivste Therapie für VHF ist die Ablationstherapie mittels Herzkatheter, eine Prozedur, bei der Gewebe in den Vorhöfen des Herzens zerstört wird um die Ausbreitungspfade von elektrischen Wellen einzuschränken. Aktuelle Therapieformen sind generisch, die Variabilität der Patienten hinsichtlich der Struktur der Vorhöfe wird nicht berücksichtigt, weshalb VHF-Symptome auch nach anfänglich positiver Therapie häufig zurückkehren.\r\n\r\nDas Ziel des DAWN-AF Projektes ist es, einen personalisierten medizinischen Ansatz zu entwickeln, der auf Computermodellierung basiert. Konkret werden digitale Zwillinge der Vorhöfe des Herzens entwickelt. Diese können zur verbesserten Planung der VHF-Ablation im Computer verwendet werden, um ein Wiederauftreten von VHF zu verhindern. Dazu werden präoperative Messungen wie das Elektrokardiogramm und tomographische Bildgebung (MRT/CT) verwendet, um anatomisch und funktionell detaillierte digitale Zwillinge zu erstellen. Da diese Daten jedoch nicht ausreichen, um die Vorhöfe eindeutig zu charakterisieren, wird für jeden Patienten ein Satz an potenziellen digitalen Zwillingen erstellt, um dann für jede einzelne Variation die jeweils ideale Ablationsbehandlung zu bestimmen. Anhand von invasiven Messungen während des Eingriffs wird dann derjenige digitale Zwilling ausgewählt, der am besten zum Patienten passt. Eine wirtschaftliche Analyse der VHF-Therapie wird den Nutzen unseres mittels digitaler Zwillinge personalisierten Therapiezugangs bewerten. Dieser Nutzen ergibt sich aus einer frühzeitigen präventiven Behandlung, aus einem länger anhaltenden Therapieerfolg, aus einer verkürzten Eingriffsdauer und einer Reduktion des Eingriffsrisikos.\r\n", "en": "Atrial Fibrillation (AF) is the most common cardiac arrhythmia. Since AF is progressive, the longer one has it, the harder it is to treat, and the risks of stroke, dementia and heart failure increase. The most effective treatment is catheter ablation therapy, a procedure that strategically destroys tissue to restrict propagation of electrical waves. However, approaches are currently generic, ignoring patient variability in atrial structure, and AF usually recurs. We aim to develop a personalised medicine approach based on computer modelling, to use digital twins to plan AF ablation to prevent recurrence. We propose to use preoperative measurements, imaging (MRI/CT) and the ECG, to build digital twins. However, these data are insufficient to uniquely characterize the atria, so we will build sets of potential digital twins for each patient, each of which will have its ideal ablation treatment determined. Invasive measurements acquired during the ablation procedure will be then used to select the digital twin that best matches the patient. Economic analysis will evaluate benefits arising from early preventative and longer-lasting treatment, reduced duration and procedural risks of interventions." }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-03-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-09-28T02:00:00+02:00", "assignment": "2023-02-01T16:15:05+01:00", "program": 112, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 2, "manager": 50966, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I 6476-B", "ethics_committee": null, "edudract_number": null, "persons": [ "7363-50966-10", "7363-91352-12", "7363-96212-12", "7363-50967-12", "7363-122514-12" ] }, { "id": 7309, "title": { "de": "Bewertung der Rolle der Succinat-Sensierung über GPR91 bei der T-Zell-vermittelten Anti-Tumor-Immunität ", "en": "Evaluating the role of succinate sensing via GPR91 in T cell-mediated \r\nanti-tumour immunity " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-03-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-09-30T02:00:00+02:00", "assignment": "2022-12-20T13:44:44+01:00", "program": null, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": 107391, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2576 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7309-60706-12", "7309-107391-10" ] } ] }