List projects.

Fields

id (integer)

Primary key.

Expansions

To activate relation expansion add the desired fields as a comma separated list to the expand query parameter like this:

?expand=<field>,<field>,<field>,...

The following relational fields can be expanded:

  • organization
  • category
  • type
  • partner_function
  • manager
  • contact
  • status
  • grant
  • research
  • event
  • study
  • language
  • program
  • funders

Filters

To filter for exact value matches:

?<fieldname>=<value>

Possible exact filters:

  • organization
  • category
  • manager
  • contact
  • status
  • grant
  • research
  • study
  • language
  • funders
  • program

For advanced filtering use lookups:

?<fieldname>__<lookup>=<value>

All fields with advanced lookups can also be used for exact value matches as described above.

Possible advanced lookups:

  • begin_planned: gt, gte, lt, lte
  • begin_effective: gt, gte, lt, lte
  • end_planned: gt, gte, lt, lte
  • end_effective: gt, gte, lt, lte
GET /v1/research/project/?format=api&offset=340&ordering=-end_effective
HTTP 200 OK
  Allow: GET, HEAD, OPTIONS
  Content-Type: application/json
  Vary: Accept
  
  {
    "count": 2329,
    "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=360&ordering=-end_effective",
    "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=320&ordering=-end_effective",
    "results": [
        {
            "id": 6763,
            "title": {
                "de": "Herz-Kreislauf-Funktion und Biomechanik bei HHcy",
                "en": "Cardiovascular function and biomechanics in HHcy"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-08-01T02:00:00+02:00",
            "begin_effective": "2021-04-01T02:00:00+02:00",
            "end_planned": "2024-07-31T02:00:00+02:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2021-10-25T14:45:30+02:00",
            "program": 72,
            "subprogram": null,
            "organization": 14054,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 53950,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P 33672",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6763-53950-10"
            ]
        },
        {
            "id": 7284,
            "title": {
                "de": "Tissue-Faktor-Aktivierung durch Gallensäuren in Hepatozyten *Wiedereinreichung",
                "en": "Bile acid-mediated tissue factor activation in hepatocytes *resubmission"
            },
            "short": null,
            "url": "https://allgemeine-paediatrie.medunigraz.at/forschung/paediatrische-haemostaseologie/tissue-faktor-aktivierung-durch-gallensaeuren-in-hepatozyten",
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2023-01-07T01:00:00+01:00",
            "begin_effective": "2023-10-01T02:00:00+02:00",
            "end_planned": "2026-01-06T01:00:00+01:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2022-12-02T11:34:30+01:00",
            "program": 72,
            "subprogram": null,
            "organization": 14091,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 62201,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P36569",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "7284-62201-10",
                "7284-101463-12",
                "7284-116323-12",
                "7284-117943-12"
            ]
        },
        {
            "id": 7984,
            "title": {
                "de": "Gewebe-infiltrierende Lymphozyten - Direkte Evaluierung der Rezeptoren ",
                "en": "Tissue-infiltrating Lymphocytes - Direct Evaluation of Receptors "
            },
            "short": "TIL-DER",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2024-04-01T02:00:00+02:00",
            "begin_effective": "2024-04-01T02:00:00+02:00",
            "end_planned": "2025-09-30T02:00:00+02:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2024-01-19T12:01:27+01:00",
            "program": 117,
            "subprogram": null,
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 97234,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                416
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "7984-97234-10"
            ]
        },
        {
            "id": 9066,
            "title": {
                "de": "Effekt von Boswellia serrata auf Schmerzintensität, zentrale und periphere Sensibilisierung, Schmerzmodulation bei gesunden Proband:innen - eine randomisierte, doppelblinde, placebo-kontrollierte, cross-over Pilot-Prüfung\r\n",
                "en": "Effect of Boswellia serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Subjects – A Randomized, Double-Blind, Placebo-Controlled, Crossover Pilot Trial"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-10-01T02:00:00+02:00",
            "begin_effective": "2025-09-01T02:00:00+02:00",
            "end_planned": "2026-03-01T01:00:00+01:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2025-07-02T16:14:25+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14069,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 101248,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2471
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "9066-58422-11",
                "9066-101248-10"
            ]
        },
        {
            "id": 9092,
            "title": {
                "de": "Gezielte elektrische Feldstimulation als neue Therapiemethode für Glioblastom Tumore",
                "en": "Targeted electrical field stimulation as a new therapeutic method for glioblastoma"
            },
            "short": "GBM-Stim",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-07-01T02:00:00+02:00",
            "begin_effective": "2025-07-01T02:00:00+02:00",
            "end_planned": "2026-06-30T02:00:00+02:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2025-07-23T12:54:09+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14011,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 104218,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "9092-104218-10"
            ]
        },
        {
            "id": 7837,
            "title": {
                "de": "Gliflozine nach akutem Myokardinfarkt",
                "en": "Understanding positive effects of gliflozins \r\nafter acute myocardial infarction\r\n"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2023-07-01T02:00:00+02:00",
            "begin_effective": "2023-12-01T01:00:00+01:00",
            "end_planned": "2025-06-30T02:00:00+02:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2023-10-18T12:46:53+02:00",
            "program": 108,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 59317,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "KLI1155",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "7837-59317-10"
            ]
        },
        {
            "id": 7983,
            "title": {
                "de": "Gewebe-infiltrierende Lymphozyten - Direkte Evaluierung der Rezeptoren",
                "en": "Tissue-infiltrating Lymphocytes - Direct Evaluation of Receptors"
            },
            "short": "TIL-DER",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2024-04-01T02:00:00+02:00",
            "begin_effective": "2024-04-01T02:00:00+02:00",
            "end_planned": "2025-09-30T02:00:00+02:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2024-01-19T11:58:34+01:00",
            "program": 117,
            "subprogram": null,
            "organization": 14092,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                416
            ],
            "funder_projectcode": "FO999909640",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 9506,
            "title": {
                "de": "Das Grazer Reanimationsregister",
                "en": "Graz Resuscitation Registry"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2026-01-01T01:00:00+01:00",
            "begin_effective": "2026-01-01T01:00:00+01:00",
            "end_planned": "2026-09-30T02:00:00+02:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2025-12-17T17:11:26+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14069,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 60097,
            "contact": null,
            "status": 2,
            "research": 10,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2471
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "9506-60097-10"
            ]
        },
        {
            "id": 8557,
            "title": {
                "de": "Services for Privacy Advancement through Generative AI and Model Sanitization",
                "en": "Services for Privacy Advancement through Generative AI and Model Sanitization"
            },
            "short": "PRIVAGAMS",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2024-10-01T02:00:00+02:00",
            "begin_effective": "2024-10-01T02:00:00+02:00",
            "end_planned": "2026-09-30T02:00:00+02:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2024-12-12T12:07:24+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14020,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 51449,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "8557-51449-10",
                "8557-135503-12"
            ]
        },
        {
            "id": 9169,
            "title": {
                "de": "Multi-Omics für personalisierte Onkologie im molekularen Tumorboard",
                "en": "Multi-omics for personalized oncology at the Molecular Tumor Board"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-10-01T02:00:00+02:00",
            "begin_effective": "2025-10-01T02:00:00+02:00",
            "end_planned": "2026-10-01T02:00:00+02:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2025-08-21T13:31:06+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14085,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 77970,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "9169-77970-10"
            ]
        },
        {
            "id": 8312,
            "title": {
                "de": "Studying TRPC6 conformational dynamics with high-speed atomic force microscopy",
                "en": "Untersuchung der Konformationsdynamik von TRPC6 mit Hochgeschwindigkeits-Atomkraftmikroskopie"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": "Transient-Rezeptor-Potential-Kanäle vom kanonischen Typ (TRPC) sind kalziumdurchlässige Ionenkanäle, die sowohl in erregbaren als auch in nicht-erregbaren Zellen vorkommen. TRPC-Kanäle werden durch Diacylglycerol (DAG) aktiviert, ein Produkt, das im Phospholipase-C-(PLC)-Weg nach der Spaltung von Phosphatidylinositol-4,5-bisphosphat (PIP2) gebildet wird. Bemerkenswerterweise sind, obwohl alle TRPC-Kanäle an (patho)physiologischen Prozessen beteiligt sind, nur TRPC6 als ein Schlüsselfaktor in der Entwicklung einer schweren Nierenerkrankung bekannt, die als fokal segmentale Glomerulosklerose (FSGS) bezeichnet wird. FSGS ist durch einen kontinuierlichen Kalziumleckstrom durch TRPC6 gekennzeichnet, der das Ionen-Gleichgewicht in den glomerulären Zellen stört und letztendlich zu einer Glomerulosklerose führt. Jüngste kryo-elektronenmikroskopische (Kryo-EM) Studien von TRPC6 konnten nur Strukturen von geschlossenen Kanälen erfassen und geben keine Einblicke in die Dynamik des Kanalöffnungsmechanismus, selbst in Anwesenheit von Aktivatoren. Ein Verständnis des Öffnungsmechanismus des TRPC6-Kanals zu gewinnen, wird jedoch unser Verständnis seiner pathophysiologischen Bedeutung erweitern. Darüber hinaus wird es die Grundlage für die Entwicklung pharmakologischer Strategien zur Regulierung des Kanals in nativen Geweben schaffen. Elektrophysiologische Analysen des TRPC6-Verhaltens auf Einzelkanalebene zeigten einen kurzlebigen geöffneten Zustand des Kanals. Folglich vermuten wir, dass das Kanalverhalten das Haupthindernis beim Verständnis des Öffnungsmechanismus von TRPC6-Kanälen in Kryo-EM-Studien darstellt. Hochgeschwindigkeits-Atomkraftmikroskopie (HS-AFM), eine hochmoderne Technik, hat in den letzten Jahren insbesondere bei der Untersuchung der Kanalöffnungsmechanismen von Ionenkanälen viel Aufmerksamkeit erlangt. Diese Technik ermöglicht hochauflösende und zeitlich aufgelöste topografische Bilder einer Probe, indem ihre Oberfläche gescannt wird. Kürzlich hat die Gruppe von Prof. Dr. Scheuring erfolgreich HS-AFM eingesetzt, um die Dynamik in den TRPV2- und TRPV3-Kanälen zu untersuchen. Um ein umfassendes Verständnis von TRPC6 zu erlangen und das Verhalten des Kanals in nativem Gewebe zu verstehen, werden wir die Dynamik des Kanalöffnungsmechanismus nach Stimulation mit verschiedenen Agonisten unter Verwendung von HS-AFM untersuchen.",
                "en": "Transient receptor potential canonical (TRPC) channels are calcium permeable ion channels found both in excitable and non-excitable cells. TRPC channels are activated by diacylglycerol (DAG), a product generated in the phospholipase C (PLC) pathway following the cleavage of phosphatidylinositol 4,5-bisphosphate (PIP2). Notably, although all TRPC channels are involved in (patho)physiological processes, only TRPC6 has been identified as playing a pivotal role in the development of a severe kidney disease known as focal segmental glomerulosclerosis (FSGS). FSGS is characterized by continuous calcium leakage through TRPC6, which disturbs ion homeostasis within glomerular cells, ultimately resulting in glomerular sclerosis. Recent cryo-electron microscopy (cryo-EM) studies of TRPC61–3 could obtain only closed-channel structures and do not give insights into the dynamics of channel gating even in presence of activators. However, gaining an understanding of the gating mechanism of the TRPC6 channel will enhance our comprehension of its pathophysiological significance. Furthermore, it will establish a foundation for developing pharmacological strategies to regulate the channel within native tissues. Electrophysiological analysis of TRPC6 behavior on a single channel level showed a short-lived open state of the channel.4 Consequently, we hypothesized that the channel behavior is the main obstacle in gaining insights into the gating mechanism of TRPC6 channels during cryo-EM.  High-speed atomic force microscopy (HS-AFM), a state-of-the-art technique, has gained high attention in recent years especially in studying ion channel gating. This technique allows high-resolution and time resolved topographic images of a sample by scanning its surface. Recently the group of Prof. Dr. Scheuring, successfully employed HS-AFM to study the dynamics in TRPV25 and TRPV36 ion channels. To gain a comprehensive understanding of TRPC6 and understand the behavior of the channel in native tissue we will study the dynamics of channel gating upon stimulation with different agonists using HS-AFM. "
            },
            "begin_planned": "2024-10-01T02:00:00+02:00",
            "begin_effective": "2024-10-01T02:00:00+02:00",
            "end_planned": "2026-09-30T02:00:00+02:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2024-07-26T11:43:41+02:00",
            "program": 116,
            "subprogram": null,
            "organization": 14011,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 116421,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                15
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "8312-73077-12",
                "8312-78591-12",
                "8312-90337-12",
                "8312-98848-12",
                "8312-116421-10"
            ]
        },
        {
            "id": 8426,
            "title": {
                "de": "Immunometabolic biomarkers and therapeutic targets in multiple sclerosis",
                "en": "Immunometabolic biomarkers and therapeutic targets in multiple sclerosis"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2024-09-01T02:00:00+02:00",
            "begin_effective": "2024-10-01T02:00:00+02:00",
            "end_planned": "2026-08-31T02:00:00+02:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2024-10-07T16:32:04+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14014,
            "category": 10,
            "type": 10,
            "partner_function": 1,
            "manager": 107391,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "8426-107391-10"
            ]
        },
        {
            "id": 6217,
            "title": {
                "de": "Therapeutisches Potenzial von AMPs bei atopischer Dermatitis",
                "en": "Therapeutic potential of antimicrobial peptides in atopic dermatitis "
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2020-10-01T02:00:00+02:00",
            "begin_effective": "2020-10-01T02:00:00+02:00",
            "end_planned": "2024-09-30T02:00:00+02:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2020-07-30T11:25:38+02:00",
            "program": 111,
            "subprogram": null,
            "organization": 14047,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 51618,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "I4939",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6217-54011-12",
                "6217-84167-12",
                "6217-87275-12",
                "6217-87663-12",
                "6217-88082-12",
                "6217-51618-10",
                "6217-107955-12",
                "6217-108412-12",
                "6217-118468-12"
            ]
        },
        {
            "id": 7309,
            "title": {
                "de": "Bewertung der Rolle der Succinat-Sensierung über GPR91 bei der T-Zell-vermittelten Anti-Tumor-Immunität ",
                "en": "Evaluating the role of succinate sensing via GPR91 in T cell-mediated \r\nanti-tumour immunity "
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2023-01-01T01:00:00+01:00",
            "begin_effective": "2023-03-01T01:00:00+01:00",
            "end_planned": "2025-12-31T01:00:00+01:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2022-12-20T13:44:44+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14014,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 107391,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2576
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "7309-60706-12",
                "7309-107391-10"
            ]
        },
        {
            "id": 7773,
            "title": {
                "de": "Entwicklung einer App zur Bewertung sowie Quantifizierung des Schweregrads idiopathischer epiretinaler Membranen und Vorschlag eines Punktesystems zur weiteren Therapiegliederung: eine prospektive Pilotstudie ",
                "en": "Developing an App to assess and quantify idiopathic epiretinal membrane severity and proposing a scoring system for further treatment recommendation: a prospective pilot study"
            },
            "short": "ERM APP",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2023-10-10T02:00:00+02:00",
            "begin_effective": "2023-10-01T02:00:00+02:00",
            "end_planned": "2024-10-10T02:00:00+02:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2023-09-19T12:46:56+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14043,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 104906,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                938,
                2194
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "7773-104906-10"
            ]
        },
        {
            "id": 7363,
            "title": {
                "de": "Digitale Zwillinge für die Behandlung von Vorhofflimmern",
                "en": "Digital Twins to Treat Atrial Fibrillation"
            },
            "short": "DAWN-AF",
            "url": null,
            "abstract": {
                "de": "Vorhofflimmern (VHF) ist die häufigste Arrhythmie des Herzens. Bei VHF handelt es sich um eine fortschreitende Erkrankung des Herzens. Je länger VHF andauert, umso schwieriger ist die Behandlung, und das Risiko Folgeschäden wie Schlaganfälle, Demenz oder Herzinsuffizienz zu erleiden nimmt zu. Die effektivste Therapie für VHF ist die Ablationstherapie mittels Herzkatheter, eine Prozedur, bei der Gewebe in den Vorhöfen des Herzens zerstört wird um die Ausbreitungspfade von elektrischen Wellen einzuschränken. Aktuelle Therapieformen sind generisch, die Variabilität der Patienten hinsichtlich der Struktur der Vorhöfe wird nicht berücksichtigt, weshalb VHF-Symptome auch nach anfänglich positiver Therapie häufig zurückkehren.\r\n\r\nDas Ziel des DAWN-AF Projektes ist es, einen personalisierten medizinischen Ansatz zu entwickeln, der auf Computermodellierung basiert. Konkret werden digitale Zwillinge der Vorhöfe des Herzens entwickelt. Diese können zur verbesserten Planung der VHF-Ablation im Computer verwendet werden, um ein Wiederauftreten von VHF zu verhindern. Dazu werden präoperative Messungen wie das Elektrokardiogramm und tomographische Bildgebung (MRT/CT) verwendet, um anatomisch und funktionell detaillierte digitale Zwillinge zu erstellen. Da diese Daten jedoch nicht ausreichen, um die Vorhöfe eindeutig zu charakterisieren, wird für jeden Patienten ein Satz an potenziellen digitalen Zwillingen erstellt, um dann für jede einzelne Variation die jeweils ideale Ablationsbehandlung zu bestimmen. Anhand von invasiven Messungen während des Eingriffs wird dann derjenige digitale Zwilling ausgewählt, der am besten zum Patienten passt. Eine wirtschaftliche Analyse der VHF-Therapie wird den Nutzen unseres mittels digitaler Zwillinge personalisierten Therapiezugangs bewerten. Dieser Nutzen ergibt sich aus einer frühzeitigen präventiven Behandlung, aus einem länger anhaltenden Therapieerfolg, aus einer verkürzten Eingriffsdauer und einer Reduktion des Eingriffsrisikos.\r\n",
                "en": "Atrial Fibrillation (AF) is the most common cardiac arrhythmia. Since AF is progressive, the longer one has it, the harder it is to treat, and the risks of stroke, dementia and heart failure increase. The most effective treatment is catheter ablation therapy, a procedure that strategically destroys tissue to restrict propagation of electrical waves. However, approaches are currently generic, ignoring patient variability in atrial structure, and AF usually recurs. We aim to develop a personalised medicine approach based on computer modelling, to use digital twins to plan AF ablation to prevent recurrence. We propose to use preoperative measurements, imaging (MRI/CT) and the ECG, to build digital twins. However, these data are insufficient to uniquely characterize the atria, so we will build sets of potential digital twins for each patient, each of which will have its ideal ablation treatment determined. Invasive measurements acquired during the ablation procedure will be then used to select the digital twin that best matches the patient. Economic analysis will evaluate benefits arising from early preventative and longer-lasting treatment, reduced duration and procedural risks of interventions."
            },
            "begin_planned": "2023-01-01T01:00:00+01:00",
            "begin_effective": "2023-03-01T01:00:00+01:00",
            "end_planned": "2025-12-31T01:00:00+01:00",
            "end_effective": "2026-09-28T02:00:00+02:00",
            "assignment": "2023-02-01T16:15:05+01:00",
            "program": 112,
            "subprogram": null,
            "organization": 14011,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 50966,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "I 6476-B",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "7363-50966-10",
                "7363-91352-12",
                "7363-96212-12",
                "7363-50967-12",
                "7363-122514-12"
            ]
        },
        {
            "id": 8324,
            "title": {
                "de": "Untersuchung der Eigenschaften von NR4As bei der Gestaltung der Tumormikroumgebung in diffusen großzelligen B-Zell-Lymphomen",
                "en": "Investigating the properties of NR4As in shaping the tumour microenvironment in diffuse large B cell lymphomas"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2024-09-02T02:00:00+02:00",
            "begin_effective": "2024-09-02T02:00:00+02:00",
            "end_planned": "2026-09-01T02:00:00+02:00",
            "end_effective": "2026-09-01T02:00:00+02:00",
            "assignment": "2024-08-05T12:39:44+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14082,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 59183,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1375
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "8324-59183-10"
            ]
        },
        {
            "id": 7328,
            "title": {
                "de": "ANEMONE: Die Antwort in der Mikroumgebung: Resistenz des malignen Pleuramesothelioms gegen alte und neue Medikamente",
                "en": "ANEMONE: The ANswer within the microEnvironment: Malignant pleural mesothelioma resistance to Old and NEw drugs "
            },
            "short": "ANEMONE",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-10-01T02:00:00+02:00",
            "begin_effective": "2022-11-01T01:00:00+01:00",
            "end_planned": "2025-10-01T02:00:00+02:00",
            "end_effective": "2026-08-31T02:00:00+02:00",
            "assignment": "2023-01-11T10:20:33+01:00",
            "program": 112,
            "subprogram": null,
            "organization": 14006,
            "category": 10,
            "type": 10,
            "partner_function": 1,
            "manager": 100911,
            "contact": null,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "I6102",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "7328-100911-10",
                "7328-119328-12"
            ]
        },
        {
            "id": 8745,
            "title": {
                "de": "Kardiometabolische und vaskuläre Auswirkungen von Adipositas im Kindesalter",
                "en": "Cardiometabolic and vascular effects of childhood obesity"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-03-01T01:00:00+01:00",
            "begin_effective": "2025-04-01T02:00:00+02:00",
            "end_planned": "2026-02-28T01:00:00+01:00",
            "end_effective": "2026-08-31T02:00:00+02:00",
            "assignment": "2025-03-28T16:01:35+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14048,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 71568,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2471
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "8745-71568-10"
            ]
        },
        {
            "id": 7062,
            "title": {
                "de": "AI powered Data Curation & Publishing Virtual Assistant",
                "en": "AI powered Data Curation & Publishing Virtual Assistant"
            },
            "short": "AIDAVA",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-09-01T02:00:00+02:00",
            "begin_effective": "2022-09-01T02:00:00+02:00",
            "end_planned": "2026-08-31T02:00:00+02:00",
            "end_effective": "2026-08-31T02:00:00+02:00",
            "assignment": "2022-06-15T15:10:02+02:00",
            "program": 211,
            "subprogram": null,
            "organization": 14020,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 99976,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": "101057062",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "7062-99976-10",
                "7062-117162-12",
                "7062-124636-12"
            ]
        }
    ]
}