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GET /v1/research/project/?format=api&offset=320&ordering=end_planned
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=340&ordering=end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=300&ordering=end_planned", "results": [ { "id": 2038, "title": { "de": "MIGRONIS - Projektfortführung", "en": "MIGRONIS - Projektfortführung" }, "short": "MIGRONIS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-07-01T02:00:00+02:00", "begin_effective": "2010-02-01T01:00:00+01:00", "end_planned": "2010-07-01T02:00:00+02:00", "end_effective": "2011-01-31T01:00:00+01:00", "assignment": "2010-01-15T15:49:27+01:00", "program": null, "subprogram": null, "organization": 14028, "category": 10, "type": 10, "partner_function": 4, "manager": 50562, "contact": 50562, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2038-50562-10" ] }, { "id": 1329, "title": { "de": "Mapping of the bound proton fraction in the elderly brain", "en": "Mapping of the bound proton fraction in the elderly brain" }, "short": "BOUND_PROTON_ELDERLY_BRAIN_FWF07", "url": null, "abstract": { "de": "The aim of this proposal is to investigate whether the bound pool fraction as a new and quantitative MR measure allows more insight into age related brain tissue changes than other quantitative MR measures. The specific aims are:\r\n\r\n*Develop a MR pulse sequence that allows to map the bound proton fraction on high field systems (>=3T) within a clinically reasonable measurement time (<15min). The sequence should offer whole brain coverage and should overcome current limitations such as the susceptibility for motion and B1 effects.\r\n\r\n*Measure the BPF in brain tissue of a large cohort of the Ausitria Stroke Prevention Study (ASPS). This gives us the opportunity to study a representative and homogeneous group of normal elderly people without a history or signs of neuropsychiatric diseases. By using a younger control cohort, we want to investigate how the BPF changes as a function of age, sex and anatonic region including cortical structures. In addition, we want to find out how the BPF varies within WMH with different severity and how it relates to the BPF in normal appearing brain tissue and to the neurocognitive performance.\r\n\r\n*Compare the sensitivity and specificity of bound proton fraction mapping to more established measures of brain tissue changes including atrophy, diffusion weighted imaging, and magnetization transfer imaging.", "en": "The aim of this proposal is to investigate whether the bound pool fraction as a new and quantitative MR measure allows more insight into age related brain tissue changes than other quantitative MR measures. The specific aims are:\r\n\r\n*Develop a MR pulse sequence that allows to map the bound proton fraction on high field systems (>=3T) within a clinically reasonable measurement time (<15min). The sequence should offer whole brain coverage and should overcome current limitations such as the susceptibility for motion and B1 effects.\r\n\r\n*Measure the BPF in brain tissue of a large cohort of the Ausitria Stroke Prevention Study (ASPS). This gives us the opportunity to study a representative and homogeneous group of normal elderly people without a history or signs of neuropsychiatric diseases. By using a younger control cohort, we want to investigate how the BPF changes as a function of age, sex and anatonic region including cortical structures. In addition, we want to find out how the BPF varies within WMH with different severity and how it relates to the BPF in normal appearing brain tissue and to the neurocognitive performance.\r\n\r\n*Compare the sensitivity and specificity of bound proton fraction mapping to more established measures of brain tissue changes including atrophy, diffusion weighted imaging, and magnetization transfer imaging." }, "begin_planned": "2007-08-01T02:00:00+02:00", "begin_effective": "2008-01-01T01:00:00+01:00", "end_planned": "2010-07-31T02:00:00+02:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2007-07-10T14:42:36+02:00", "program": 72, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 51279, "contact": 51279, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P20103", "ethics_committee": null, "edudract_number": null, "persons": [ "1329-51279-10" ] }, { "id": 1885, "title": { "de": "Die Rolle von Prominin-1/CD133 positiven Mikropartikeln in der Neubildung von Nervenzellen nach Schädelhirntraumata", "en": "Die Rolle von Prominin-1/CD133 positiven Mikropartikeln in der Neubildung von Nervenzellen nach Schädelhirntraumata" }, "short": "Prominin-1/CD133 ", "url": null, "abstract": { "de": "Membran-umhüllte Mikropartikel sind kleine Abschnürungen der Zellmembran. Mikropartikel tragen typischerweise die Zellmembran-Antigene und bioaktive Moleküle wie Metabolite und Proteine ihrer Herkunftszelle. Die Freisetzung der Mikropartikel kann zur Signaltransmission zwischen neuralen Stammzellen beitragen. Die Botenstoffe, die in Mikropartikeln gespeichert sind, unterstützen möglicherweise die Neubildung von Neuronen nach zerebralen Schädigungen.\r\nDie Neubildung von Neuronen ist einer der wichtigsten Mechanismen in der Regneration von geschädigtem zerebralen Gewebe. Die Identifizierung und Charakterisierung spezifischer Biomarker der Neurogenese ist eine essenzielle Voraussetzung für die Entwicklung innovativer regenerativer Therapien nach degenerativen Erkrankungen (Parkinson, Alzheimer) und neurologischen Schädigungen (Schlaganfall, Ischämie, Schädelhirntrauma).\r\n\r\nDeshalb ist das Ziel dieses Forschungsvorhabens die Bedeutung der in der zerebrospinalen Flüssigkeit zirkulierenden CD133 positiven Mikropartikel für die verletzungsbedingte Stimulation der Neurogenese zu charakterisieren.", "en": "Membran-umhüllte Mikropartikel sind kleine Abschnürungen der Zellmembran. Mikropartikel tragen typischerweise die Zellmembran-Antigene und bioaktive Moleküle wie Metabolite und Proteine ihrer Herkunftszelle. Die Freisetzung der Mikropartikel kann zur Signaltransmission zwischen neuralen Stammzellen beitragen. Die Botenstoffe, die in Mikropartikeln gespeichert sind, unterstützen möglicherweise die Neubildung von Neuronen nach zerebralen Schädigungen.\r\nDie Neubildung von Neuronen ist einer der wichtigsten Mechanismen in der Regneration von geschädigtem zerebralen Gewebe. Die Identifizierung und Charakterisierung spezifischer Biomarker der Neurogenese ist eine essenzielle Voraussetzung für die Entwicklung innovativer regenerativer Therapien nach degenerativen Erkrankungen (Parkinson, Alzheimer) und neurologischen Schädigungen (Schlaganfall, Ischämie, Schädelhirntrauma).\r\n\r\nDeshalb ist das Ziel dieses Forschungsvorhabens die Bedeutung der in der zerebrospinalen Flüssigkeit zirkulierenden CD133 positiven Mikropartikel für die verletzungsbedingte Stimulation der Neurogenese zu charakterisieren." }, "begin_planned": "2009-08-01T02:00:00+02:00", "begin_effective": "2009-08-01T02:00:00+02:00", "end_planned": "2010-07-31T02:00:00+02:00", "end_effective": "2010-07-31T02:00:00+02:00", "assignment": "2009-08-05T15:15:53+02:00", "program": null, "subprogram": "Land Steiermark Antrag über 5.000,- Euro", "organization": 14050, "category": 10, "type": 10, "partner_function": 4, "manager": 61927, "contact": 61927, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1885-61927-10" ] }, { "id": 2149, "title": { "de": "Mitochondrien Dynamik und Kalziumsignale", "en": "Mitochondrien Dynamik und Kalziumsignale" }, "short": "FluoSens III", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-05T02:00:00+02:00", "begin_effective": "2010-07-05T02:00:00+02:00", "end_planned": "2010-08-30T02:00:00+02:00", "end_effective": "2010-08-30T02:00:00+02:00", "assignment": "2010-03-03T13:26:06+01:00", "program": null, "subprogram": "Generation Innovation Praktika", "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 50810, "contact": 50810, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "826983", "ethics_committee": null, "edudract_number": null, "persons": [ "2149-50810-10" ] }, { "id": 2168, "title": { "de": "Funktionelle MRT zur Charakterisierung der neutralen Korrelate des Multi-Tasking unter besonderer Berücksichtigung geschlechtsbezogener Unterschiede", "en": "A functional MRI study probing sex-related effects in multi tasking" }, "short": "MRT_MULTITASKING", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-09-01T02:00:00+02:00", "begin_effective": "2009-09-01T02:00:00+02:00", "end_planned": "2010-08-30T02:00:00+02:00", "end_effective": "2011-06-30T02:00:00+02:00", "assignment": "2010-04-08T14:59:38+02:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 50173, "contact": 50173, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2168-50173-10" ] }, { "id": 2148, "title": { "de": "ATP Messungen in einzelnen Zellen", "en": "ATP Messungen in einzelnen Zellen" }, "short": "FluoSens II", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-05T02:00:00+02:00", "begin_effective": "2010-07-05T02:00:00+02:00", "end_planned": "2010-08-30T02:00:00+02:00", "end_effective": "2010-08-30T02:00:00+02:00", "assignment": "2010-03-03T13:25:25+01:00", "program": null, "subprogram": "Generation Innovation Praktika", "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 50810, "contact": 50810, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "826984", "ethics_committee": null, "edudract_number": null, "persons": [ "2148-50810-10" ] }, { "id": 2147, "title": { "de": "Optimierung der Verwendung von fluoreszierenden Proteinen in der Zellphysiologie", "en": "Optimierung der Verwendung von fluoreszierenden Proteinen in der Zellphysiologie" }, "short": "FluoSens I", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-05T02:00:00+02:00", "begin_effective": "2010-07-05T02:00:00+02:00", "end_planned": "2010-08-30T02:00:00+02:00", "end_effective": "2010-08-30T02:00:00+02:00", "assignment": "2010-03-03T13:24:03+01:00", "program": null, "subprogram": "Generation Innovation Praktika", "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 50810, "contact": 50810, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "826977", "ethics_committee": null, "edudract_number": null, "persons": [ "2147-50810-10" ] }, { "id": 1586, "title": { "de": "Predictive markers of spontaneous preterm delivery", "en": "Predictive markers of spontaneous preterm delivery" }, "short": "PREDICTIVE_MARKERS", "url": null, "abstract": { "de": "Frühgeburtlichkeit ist eine Hauptursache für perinatale Morbidität und Mortalität. In Bezug auf die neurologische Langzeitprognose ist die periventrikuläre Leukoenzephalomalazie (PVL) und die daraus resultierende Zerebralparese eine der häufigsten Ursachen für Behinderungen. Das Problem des Screenings und der Diagnostik liegt darin, dass die Frühgeburt ein Endpunkt verschiedener Ätiologien ist. In diesem Projekt wollen wir Marker evaluieren, die unterschiedlichen ätiologischen Kategorien entsprechen: Polymorphismen von Interleukin-10 und Interleukin-4 (Entzündung), SERPINE1 (uteroplazentare Vaskulopathie), messenger RNA von Cortikotropin-releasing-Hormon (Wehenauslösung) und Pentraxin 3 (Entzündung). Das Screeningpotential dieses Marker-Sets wird dabei sowohl für die Frühgeburt als auch für Frühgeburt mit Entwicklung einer PVL evaluiert. Diese Marker sollen den Einsatz prophylaktischer und therapeutischer Interventionen (Progesteron, anti-inflammatorische Interleukine) ermöglichen.", "en": "Frühgeburtlichkeit ist eine Hauptursache für perinatale Morbidität und Mortalität. In Bezug auf die neurologische Langzeitprognose ist die periventrikuläre Leukoenzephalomalazie (PVL) und die daraus resultierende Zerebralparese eine der häufigsten Ursachen für Behinderungen. Das Problem des Screenings und der Diagnostik liegt darin, dass die Frühgeburt ein Endpunkt verschiedener Ätiologien ist. In diesem Projekt wollen wir Marker evaluieren, die unterschiedlichen ätiologischen Kategorien entsprechen: Polymorphismen von Interleukin-10 und Interleukin-4 (Entzündung), SERPINE1 (uteroplazentare Vaskulopathie), messenger RNA von Cortikotropin-releasing-Hormon (Wehenauslösung) und Pentraxin 3 (Entzündung). Das Screeningpotential dieses Marker-Sets wird dabei sowohl für die Frühgeburt als auch für Frühgeburt mit Entwicklung einer PVL evaluiert. Diese Marker sollen den Einsatz prophylaktischer und therapeutischer Interventionen (Progesteron, anti-inflammatorische Interleukine) ermöglichen." }, "begin_planned": "2008-09-01T02:00:00+02:00", "begin_effective": "2008-09-01T02:00:00+02:00", "end_planned": "2010-08-31T02:00:00+02:00", "end_effective": "2011-02-28T01:00:00+01:00", "assignment": "2008-07-25T13:12:34+02:00", "program": 79, "subprogram": null, "organization": 14064, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1984, "title": { "de": "Does fracture instability cause leg length discrepancy?", "en": "Does fracture instability cause leg length discrepancy?" }, "short": "FRACTURE_INSTABILITY", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-09-01T02:00:00+02:00", "begin_effective": "2009-09-01T02:00:00+02:00", "end_planned": "2010-08-31T02:00:00+02:00", "end_effective": "2010-08-31T02:00:00+02:00", "assignment": "2009-11-18T15:17:20+01:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 57571, "contact": 57571, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 549 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1984-57571-10" ] }, { "id": 1581, "title": { "de": "Identification and functional characterisation of Nuclear Orphan Receptors as Tumor Suppressor Genes in aggressive non-Hodgkin`s Lymphomas and acute lymphoblastic leukemia", "en": "Identification and functional characterisation of Nuclear Orphan Receptors as Tumor Suppressor Genes in aggressive non-Hodgkin`s Lymphomas and acute lymphoblastic leukemia" }, "short": "non-Hodgkin`s Lymphoma", "url": null, "abstract": { "de": "NR4A1 (also called Nur77, TR3, or NGFI-B), NR4A2 (Nurr1 or RNR-1) and NR4A3 (Nor-1 or Minor) are three members of an orphan nuclear hormone receptor family referred to as Nur77 family. They are all transcription factors belonging to the superfamily of steroid nuclear hormone receptors. These nuclear hormone receptors (NR) are classified as early response genes, are induced by a diverse range of signals, including fatty acids, stress, growth factors, cytokines, peptide hormones, neurotransmitters, and physical stimuli for example magnetic fields or shear stress. In line with the pleiotropic physiological stimuli that induce the NR4A subgroup, these orphan NRs have been implicated in cell cycle regulation, apoptosis, inflammation, atherogenesis and more recently in carcinogenesis. \r\nThe ultimate growth of a tumour depends on not only the rate of tumour cell proliferation, but also the rate of tumour cell death (=apoptosis). NR4A1 controls both survival and death of cancer cells. \r\nIn contrast to NR4A1, only pro-survival effects, but not pro-apoptotic effects, have been reported for NR4A2. \r\nNR4A3 has been shown to be functionally redundant with NR4A1 in T-cell apoptosis. Results also suggest that NR4A1 and NR4A3 have non-redundant functions as well.\r\nThe most convincing evidence that nuclear orphan receptors function as critical tumor suppressors is the observation that the abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to rapid development of acute myeloid leukemia. Evidence of nuclear orphan receptors acting as tumor suppressor genes in B-cell malignancies comes from the observation that Epstein-Barr virus EBNA 2 blocks NR4A1 mediated apoptosis in B-cells and from gene expression profiling in diffuse large B-cell lymphoma (DLBCL) in which over expression of NR4A3 is found in cured or refractory DLBCL, as opposed to a fatal course of disease. Hence, it is speculated that NR4A3 increases the apoptotic response to chemotherapy in curable DLBCL.\r\n\r\nThe aim of our study was to comprehensively study NR expression and function in B-cell malignancies and to define the nuclear orphan receptors NR4A1 and NR4A1 as cooperative putative tumor suppressor genes (TSG) in B-cell malignancies.\r\n\r\n", "en": "NR4A1 (also called Nur77, TR3, or NGFI-B), NR4A2 (Nurr1 or RNR-1) and NR4A3 (Nor-1 or Minor) are three members of an orphan nuclear hormone receptor family referred to as Nur77 family. They are all transcription factors belonging to the superfamily of steroid nuclear hormone receptors. These nuclear hormone receptors (NR) are classified as early response genes, are induced by a diverse range of signals, including fatty acids, stress, growth factors, cytokines, peptide hormones, neurotransmitters, and physical stimuli for example magnetic fields or shear stress. In line with the pleiotropic physiological stimuli that induce the NR4A subgroup, these orphan NRs have been implicated in cell cycle regulation, apoptosis, inflammation, atherogenesis and more recently in carcinogenesis. \r\nThe ultimate growth of a tumour depends on not only the rate of tumour cell proliferation, but also the rate of tumour cell death (=apoptosis). NR4A1 controls both survival and death of cancer cells. \r\nIn contrast to NR4A1, only pro-survival effects, but not pro-apoptotic effects, have been reported for NR4A2. \r\nNR4A3 has been shown to be functionally redundant with NR4A1 in T-cell apoptosis. Results also suggest that NR4A1 and NR4A3 have non-redundant functions as well.\r\nThe most convincing evidence that nuclear orphan receptors function as critical tumor suppressors is the observation that the abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to rapid development of acute myeloid leukemia. Evidence of nuclear orphan receptors acting as tumor suppressor genes in B-cell malignancies comes from the observation that Epstein-Barr virus EBNA 2 blocks NR4A1 mediated apoptosis in B-cells and from gene expression profiling in diffuse large B-cell lymphoma (DLBCL) in which over expression of NR4A3 is found in cured or refractory DLBCL, as opposed to a fatal course of disease. Hence, it is speculated that NR4A3 increases the apoptotic response to chemotherapy in curable DLBCL.\r\n\r\nThe aim of our study was to comprehensively study NR expression and function in B-cell malignancies and to define the nuclear orphan receptors NR4A1 and NR4A1 as cooperative putative tumor suppressor genes (TSG) in B-cell malignancies." }, "begin_planned": "2008-10-01T02:00:00+02:00", "begin_effective": "2008-10-01T02:00:00+02:00", "end_planned": "2010-09-30T02:00:00+02:00", "end_effective": "2010-09-30T02:00:00+02:00", "assignment": "2008-07-17T12:24:53+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51930, "contact": 51930, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 836 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1581-51930-10" ] }, { "id": 1937, "title": { "de": "CII-AT-0042-05-0910 - Image Processing, Information Engineering & Interdisciplinary Knowledge Exchange", "en": "CII-AT-0042-05-0910 - Image Processing, Information Engineering & Interdisciplinary Knowledge Exchange" }, "short": "CEEPUS Imaging Processing", "url": "http://www.ceepus.info", "abstract": { "de": null, "en": null }, "begin_planned": "2009-10-01T02:00:00+02:00", "begin_effective": "2009-10-01T02:00:00+02:00", "end_planned": "2010-09-30T02:00:00+02:00", "end_effective": "2010-09-30T02:00:00+02:00", "assignment": null, "program": null, "subprogram": null, "organization": 14106, "category": 10, "type": 10, "partner_function": 2, "manager": 51913, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1937-51913-10" ] }, { "id": 1956, "title": { "de": "Schlaganfallrisikofaktoren in der Grazer Bevölkerung: Was bewirkt eine wiederholte Vorsorgeuntersuchung? Ergebnisse der Austrian Stroke Prevention Study", "en": "Schlaganfallrisikofaktoren in der Grazer Bevölkerung: Was bewirkt eine wiederholte Vorsorgeuntersuchung? Ergebnisse der Austrian Stroke Prevention Study" }, "short": "SCHLAGANFALLRISIKO_GRAZER_BEVOELK", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-06-01T02:00:00+02:00", "begin_effective": "2009-06-01T02:00:00+02:00", "end_planned": "2010-09-30T02:00:00+02:00", "end_effective": "2010-09-30T02:00:00+02:00", "assignment": "2009-10-22T19:32:12+02:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1617, "title": { "de": "Phase 4 development EORTC Quality of Life module specific to Endometrail Cancer (EORTC QLQ-EN34)", "en": "Phase 4 development EORTC Quality of Life module specific to Endometrail Cancer (EORTC QLQ-EN34)" }, "short": "EORTC QLQ-EN34", "url": null, "abstract": { "de": "Endometrial cancer rates have risen over the last two decades, in some countries very significantly due to a combination of factors that includes an ageing population, increased obesity, and exposure to oestrogens.\r\nWith this burgeoning research agenda there is an urgent need to develop a specific quality of life measure for women with endometrial cancer that is sensitive to the impact of treatments so that their affect on quality of life can be assessed. In addition patients are increasingly encouraged to seek information about the impact of treatment on their quality of life so that they can make informed choices about their treatment and care.", "en": "Endometrial cancer rates have risen over the last two decades, in some countries very significantly due to a combination of factors that includes an ageing population, increased obesity, and exposure to oestrogens.\r\nWith this burgeoning research agenda there is an urgent need to develop a specific quality of life measure for women with endometrial cancer that is sensitive to the impact of treatments so that their affect on quality of life can be assessed. In addition patients are increasingly encouraged to seek information about the impact of treatment on their quality of life so that they can make informed choices about their treatment and care." }, "begin_planned": "2008-07-01T02:00:00+02:00", "begin_effective": "2008-07-01T02:00:00+02:00", "end_planned": "2010-09-30T02:00:00+02:00", "end_effective": "2010-09-30T02:00:00+02:00", "assignment": "2008-09-16T16:47:26+02:00", "program": null, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 1, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 442 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1617-57392-12" ] }, { "id": 2126, "title": { "de": "Auswirkungen von Stressoren bei Kindern und Jugendlichen", "en": "Effects of stress in adolescents" }, "short": "STRESSOREN_KINDER_JUGENDLICHE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-03-01T01:00:00+01:00", "begin_effective": "2010-03-01T01:00:00+01:00", "end_planned": "2010-09-30T02:00:00+02:00", "end_effective": "2010-09-30T02:00:00+02:00", "assignment": "2010-02-22T11:26:29+01:00", "program": null, "subprogram": null, "organization": 29447, "category": 10, "type": 10, "partner_function": 1, "manager": 60040, "contact": 60040, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2126-60040-10", "2126-52274-11" ] }, { "id": 2391, "title": { "de": "Einfluss der Knochenentnahmetechnik auf die Osteoblastenaktivität", "en": "Effect of Bone Harvesting Methods to the Osteoblast activity" }, "short": "KNOCHENENTNAHME_OSTEOBLAST", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-04-01T02:00:00+02:00", "begin_effective": "2011-01-26T01:00:00+01:00", "end_planned": "2010-10-01T02:00:00+02:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2011-02-04T09:47:14+01:00", "program": null, "subprogram": null, "organization": 14057, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2569, "title": { "de": "Anbahnungsfinanzierung: Genetik von Patienten mit Meningokokkeninfektionen Projektnummer: 830184", "en": "host genetics of meningococcal infections" }, "short": "HOST GENETICS MENINGOCOCC INFECT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-06-22T02:00:00+02:00", "begin_effective": "2010-06-22T02:00:00+02:00", "end_planned": "2010-10-13T02:00:00+02:00", "end_effective": "2010-10-13T02:00:00+02:00", "assignment": "2011-09-07T13:23:21+02:00", "program": 54, "subprogram": null, "organization": 14091, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2305, "title": { "de": "Anbahnungsfinanzierung (DEVAG) - Projektnummer: 829019", "en": "Anbahnungsfinanzierung (DEVAG)" }, "short": "DEVAG", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-06-03T02:00:00+02:00", "begin_effective": "2010-07-01T02:00:00+02:00", "end_planned": "2010-10-13T02:00:00+02:00", "end_effective": "2010-10-16T02:00:00+02:00", "assignment": "2010-09-17T11:46:55+02:00", "program": 54, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 51632, "contact": 51632, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "829019", "ethics_committee": null, "edudract_number": null, "persons": [ "2305-51632-10" ] }, { "id": 1505, "title": { "de": "Genetische Determinaten zerebraler Kleingefäßerkrankung", "en": "Genetic determinants of cerebral small vessel disease" }, "short": "CEREBRALVESSEL_FWF07", "url": null, "abstract": { "de": "Die Kleingefäßerkrankung ist die zweithäufigste endemische Schädigung des alternden Gehirns nach Alzheimer Pathologie. Leukoaraiose und Lakunen sind die Hauptläsionen dieser Entität und können mittels Magnet Resonanz (MR) Tomografie des Gehirns dargestellt werden. Bis zu 90% aller Personen über dem 65.Lebensjahr zeigen Laukaraiose unterschiedlichen Schweregrades.\r\nDas Ziel unserer Studie ist die Komplexität der zerebralen Kleingefäßerkrankung auf genetischer Basis aufzutrennen, um ein besseres Verständnis des Pathomechanismus dieser Läsion zu erhalten. Im ersten Schritt werden wir eine genomweite Assoziationsstudie und ein Feinmapping der Kopplungsregionen auf Chromosom 4 und 17 in der Austrian Stroke Prevention Study Kohorte durchführen. Im zweiten Schritt werden wir Familien aus der Basiskohorte der Austrian Stroke Prevention Study rekrutieren. Die Familienmitglieder werden dem selben Studienprookoll unterzogen, wie die Probanden der Basiskohorte. In dieser Familienstudie werden wir Schätzungen zur Vererblichkeit der verschiedenen Läsionscharakteristika und die genetische Korrelation zwischen diesen Läsionsmerkmalen und ihren Hauptrisikofaktoren berechnen. Das Spektrum möglicher Endophenotypen der zerebraler Kleingefäßerkrankung soll aufgezeigt werden. In der Familienstudie werden wir Gene verifizieren, die mit dieser Hirnschädigung in früheren Studien identifiziert wurden.\r\nDie gleichzeitige Verfügbarkeit einer Familien- und einer populationsbasierenden Kohorte mit identem Protokoll bietet die einmalige Gelegenheit zur Identifizierung relevanter Gene, da Kopplungs- und Assoziationsstudien in Kombination duchgeführt werden können. Die Identifizierung solcher Gene wird unser äußerst unvollständiges pathophysiologisches Verständnis über die zerebrale Kleingefäßerkrankung verbessern und die Entdeckung neuer therapeutischer Ziele ermöglichen.", "en": "Cerebral small vessel disease is the second most common endemic entity of the ageing brain following Alzheimer pathology. Its hallmark lesions are leuko-araiosis and lacunar infarctions, which can be non-invasively depicted with brain magnetic resonance imaging. Up to 90% of persons above the age of 65 years present with leuko-araiosis. Lacunes occur less common with a frequency of 6% to 20%. Decreased mobility of the elderly due to disequilibrium and gait abnormalities, and progressive cognitive impairment up to dementia are frequent clinical sequelae of cerebral microangiopathy. Established risk factors are arterial hypertension and advancing age. There does not exist any established treatment yet which allows to modify the evolution of small vessel disease-related brain damage. \r\nThe heritability of leukoaraiosis volume ranges between 55% and 73%. There are no heritability estimates of other characteristics of white matter lesions such as type and progression are available. Similarly, the heritability of other components of small vessel disease such as lacunes, brain atrophy and microbleeds have not yet been investigated yet. Association studies indicated that the APOE, ACE, eNOS, MTHFR genes might be related to these pathologies. We found positive associations with APOE, PON1 as well as the AGT, with considerable evidence for a causal relationship for the latter. Very recently, the results of the first genome wide scan on white matter lesion volume have been reported by the Framingham Heart Study describing a significant LOD score on chromosome 4 and a suggestive LOD score for linkage on chromosome 17.\r\n \tThe aim of our study is to genetically dissect the complexity of cerebral small vessel disease in order to better understand the pathomechanisms leading to these lesions. First we will apply genome wide association as well as fine map the linkage regions on Chr 4 and 17 in the the Austrian Stroke Prevention Study cohort, which is one of the largest community-dwelling studies on cerebral small vessel disease and the study with the longest MRI follow up so far. Second, we will recruit families ascertained through participants of the Austrian Stroke Prevention Study. Family members will undergo the same study protocol including brain MRI as the probands in the population based cohort. In the family based cohort we will estimate heritability of and genetic correlation between different lesion characteristics of cerebral small vessel disease and its major risk factors. We aim to develop a spectrum of possible endophenotypes for cerebral small vessel disease. In the family based cohort we also aim to verify genes associated with cerebral small vessel disease in previous studies. \r\nThe co-existence of a family and a population based cohort characterized with identical study protocol will offer a unique and outstanding resource to identify genes by allowing for the combined use of linkage and association. Knowledge of genes involved in cerebral small vessel disease will improve our understanding of the pathogenesis of these lesions and will possibly facilitate the development of novel therapeutic targets.\r\n" }, "begin_planned": "2007-11-01T01:00:00+01:00", "begin_effective": "2008-05-01T02:00:00+02:00", "end_planned": "2010-10-31T02:00:00+02:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2008-03-31T18:04:38+02:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51912, "contact": 51912, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P20545", "ethics_committee": null, "edudract_number": null, "persons": [ "1505-51912-10" ] }, { "id": 1944, "title": { "de": "The role of HOXB4 in renal development, maldevelopment of the kidney and tumorigeneses of renal neoplasms", "en": "The role of HOXB4 in renal development, maldevelopment of the kidney and tumorigeneses of renal neoplasms" }, "short": "ROLE OF HOXB4", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-11-01T01:00:00+01:00", "begin_effective": "2009-11-01T01:00:00+01:00", "end_planned": "2010-10-31T02:00:00+02:00", "end_effective": "2010-10-31T02:00:00+02:00", "assignment": "2009-10-07T13:44:40+02:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 52569, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1944-52569-10" ] }, { "id": 2323, "title": { "de": "Computermodelle strukturell degenerativer Herzerkrankungen", "en": "Computermodelle strukturell degenerativer Herzerkrankungen" }, "short": "Computermodelle Herzerkrankung", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-11-01T01:00:00+01:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2010-10-31T02:00:00+02:00", "end_effective": "2010-07-31T02:00:00+02:00", "assignment": "2010-10-05T11:55:03+02:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 1, "manager": 51502, "contact": 51502, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2323-51502-10" ] } ] }