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GET /v1/research/project/?format=api&offset=300&ordering=-begin_planned
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=320&ordering=-begin_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=280&ordering=-begin_planned", "results": [ { "id": 8252, "title": { "de": "Neonatologischer Lungenultraschall bei Neugeborenen 15 Minuten nach der Geburt, um den Bedarf und Dauer einer Atemunterstützung vorherzusagen", "en": "Neonatologist-performed lung ultrasound (NPLUS) in neonates 15 minutes after birth to predict requirement for respiratory support persisting more than 1 hour" }, "short": "NPLUS in neonates", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-01T01:00:00+01:00", "begin_effective": "2024-04-01T02:00:00+02:00", "end_planned": "2026-02-01T01:00:00+01:00", "end_effective": "2025-04-30T02:00:00+02:00", "assignment": "2024-06-13T13:19:26+02:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 86558, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8252-79516-11", "8252-86558-10" ] }, { "id": 7977, "title": { "de": "Splicing-Faktor Mutationen in myeloischen Neoplasien", "en": "Aberrant innate immune signaling in spliceosome-mutant myeloid neoplasms" }, "short": "Engineering spliceosome mutations", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-01T01:00:00+01:00", "begin_effective": "2024-02-01T01:00:00+01:00", "end_planned": "2026-01-31T01:00:00+01:00", "end_effective": "2026-01-31T01:00:00+01:00", "assignment": "2024-01-17T11:45:23+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 50747, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1564 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7977-50747-10" ] }, { "id": 8008, "title": { "de": "Identifizierung neuer Targets in der TP53-vermittelten Therapieresistenz bei akuter myeloischer Leukämie durch CRISPRko-Screens", "en": "Identifying novel targets to combat aberrant TP53 mediated therapeutic resistance in acute myeloid leukemia using CRISPRko screens" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-01T01:00:00+01:00", "begin_effective": "2024-02-01T01:00:00+01:00", "end_planned": "2025-08-01T02:00:00+02:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2024-02-01T11:43:46+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 1, "manager": 101484, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1564 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8008-103341-12", "8008-101484-10" ] }, { "id": 7934, "title": { "de": "Maschinelles Hören im Kreißsaal: Pilotstudie zur automatischen Evaluierung der neonatalen Lungenfunktion anhand des ersten Schreis", "en": "Maschinelles Hören im Kreißsaal: Pilotstudie zur automatischen Evaluierung der neonatalen Lungenfunktion anhand des ersten Schreis" }, "short": "Maschinelles Hören im Kreißsaal", "url": null, "abstract": { "de": "Die in den ersten Lebensminuten produzierten Laute von Neugeborenen sorgen dafür, dass ein Teil der Ausatemluft vom Kehlkopf zurückpendelt und so das Fruchtwasser aus der Lunge in das umliegende Gewebe presst. Aufgrund unterschiedlich fortgeschrittener Lungenentwicklung gibt es mitunter hörbare Unterschiede zwischen Termin- und Frühgeborenen. Dieses Projekt evaluiert die Durchführbarkeit von standardisierten Tonaufnahmen in der Geburtssituation. Basierend auf Pilotdaten erfolgt erstmals eine umfassende Beschreibung akustischer Merkmale der ersten Laute von Termin- und Frühgeborenen sowie die Validierung künstlicher Intelligenz zur Einschätzung neonataler Lungenfunktion.", "en": null }, "begin_planned": "2024-01-15T01:00:00+01:00", "begin_effective": "2024-03-01T01:00:00+01:00", "end_planned": "2025-01-14T01:00:00+01:00", "end_effective": "2025-05-31T02:00:00+02:00", "assignment": "2023-12-15T12:07:02+01:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 79651, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7934-79651-10", "7934-91531-12", "7934-77049-12" ] }, { "id": 8233, "title": { "de": "Die Nr4a1/P53 Achse in der Immun Evasion von Lymphomen", "en": "NR4A1-P53 AXIS IN THE IMMUNE EVASION OF AGGRESSIVE LYMPHOMAS" }, "short": "LYMPHO-CHECK", "url": null, "abstract": { "de": "Aggressive Lymphome gehören zu den häufigsten Arten von Lymphdrüsenkrebs und stellen eine große Herausforderung für die Behandlung dar. Checkpoint-Blockade-Therapien (CBTs) haben sich als vielversprechender Weg erwiesen, um der Umgehung der Anti-Tumor-Immunantwort durch den Tumor entgegenzuwirken. Trotz ihres Potenzials sind CBTs mit erheblichen Kosten verbunden und basieren häufig auf Trial-and-Error-Ansätzen. Zudem sprechen nur ein kleiner Prozentsatz der Lymphom-Patienten (10-20%) auf CBT an, teilweise aufgrund eines Mangels an Verständnis darüber, wie Immun-Checkpoints während der Entwicklung von Lymphomen reguliert werden, sowie aufgrund des Fehlens prädiktiver Biomarker. Unsere jüngsten Forschungsergebnisse haben wichtige Faktoren aufgedeckt, die zu schlechten Ergebnissen bei Patienten mit diffusen großzelligen B-Zell-Lymphomen (DLBCL) beitragen. Wir beobachteten signifikante Abnahmen der NR4A1- und p53-Spiegel, die wichtige Regulatoren der Genexpression sind, vergesellschaftet mit erhöhten Checkpoint-Komponenten-Gehalt. Bei Mäusen führte die Deletion von NR4A1 zu reduzierten p53-Spiegeln, beschleunigter Lymphomentwicklung und erhöhter Expression von immuninhibitorischen Checkpoint-Komponenten. Diese Ergebnisse deuten auf eine funktionelle Beziehung zwischen NR4A1 und p53, die in der Immunantwort auf Tumore die Expression von Checkpoint-Komponenten in aggressiven Lymphomen reguliert.\r\nUnser vorgeschlagenes Forschungsprojekt zielt darauf ab, diese Herausforderungen durch die Entwicklung neuer Mausmodelle mit spezifischen Deletionen von NR4A1 und/oder p53 in B-Zellen anzugehen. Unter Verwendung fortschrittlicher molekularer und genomweiter Techniken werden wir umfassend untersuchen, wie Lymphome in diesen Modellen entstehen. Außerdem werden wir eine Methode zur wiederholten Gewebsflüssigkeitsentnahme adaptieren und damit wiederholte Messungen von Zytokinsignalen und zellulären Veränderungen in sich entwickelnden Tumoren durchführen, wodurch wertvolle Einblicke in das Lymphom-Mikromilieu gewonnen werden. Mit Hilfe dieser Modelle hoffen wir, neue Checkpoint-Blockade-Therapien für aggressive Lymphom entwickeln und auf den Status von NR4A1 und p53 abstimmen zu können. Zur Validierung unserer Ergebnisse werden wir eine große Kohorte von Lymphomproben von Patienten analysieren und mit öffentlich verfügbaren Datensätzen vergleichen. Letztendlich ist es unser Ziel, die klinische Relevanz der NR4A1-p53-Checkpoint-Achse zu bewerten und neue Biomarker zu identifizieren, die bei aggressiven Lymphomen als Entscheidungshilfe für die Behandlung mit Checkpoint-Inhibitoren dienen können. Durch unsere Forschung wollen wir die Ergebnisse für Patienten mit aggressiven Lymphomen verbessern, indem wir wirksamere und personalisierte Behandlungsstrategien entwickeln.\r\n", "en": "Aggressive lymphomas are among the most common types of lymphoid cancers and consist of Burkitt’s lymphoma, diffuse large B cell lymphoma (DLBCL), follicular lymphoma grade 3. While checkpoint blockade therapies (CBTs) have emerged as a promising avenue to counteract tumor evasion, this treatment form comes with substantial cost burdens and often rely on trial-and-error approaches. Importantly, only a small percentage of lymphoma patients (10-20%) respond favorably to CBT, partly due to the limited understanding of the regulation of immune checkpoints during lymphoma development and the absence of predictive biomarkers. Our recent investigations have shed light on key factors contributing to poor outcomes in patients with DLBCL. We observed significant decreases in the levels of NR4A1 and p53, which are important regulators of gene expression and known tumor suppressors, alongside high expression of checkpoint components. In mice, depletion of NR4A1 led to reduced p53 levels, accelerated lymphoma development, and increased expression of immune-inhibitory checkpoint components, particularly in animals with intact immune systems. These and other findings suggest a functional relationship involving NR4A1, p53, and the orchestrating immune evasive mechanisms in aggressive lymphomas.\r\nOur proposed research project aims to address this axis by developing new mouse models with specific and inducible deletion of NR4A1 and/or p53 in B cells. Using advanced molecular and genomic techniques, we will comprehensively study lymphoma development in these models. We will also implement a tissue fluid sampling method to repeatedly measure cytokine signals and cellular changes within evolving tumors, providing valuable insights into the lymphoma microenvironment. By leveraging these models, we aim to tailor CBTs based on the status of NR4A1 and p53. To clinically validate our findings, we will analyze a large cohort of lymphoma samples from GRAZ lymphoma cohort and compare them with publicly available datasets. Ultimately, our goal is to functionally establish the clinical relevance of the NR4A1-p53-checkpoint axis and identify new biomarkers that can help guide treatment decisions involving checkpoint inhibitors for aggressive lymphomas. Through our research, we are poised to improve outcomes for patients with aggressive lymphomas by developing more effective and personalized treatment strategies.\r\n" }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-06-03T02:00:00+02:00", "end_planned": "2028-12-31T01:00:00+01:00", "end_effective": "2029-06-02T02:00:00+02:00", "assignment": "2024-06-03T13:00:14+02:00", "program": 113, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 3, "manager": 59183, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "FG 30", "ethics_committee": null, "edudract_number": null, "persons": [ "8233-100134-12", "8233-59183-10", "8233-79614-12", "8233-82501-12", "8233-85928-12", "8233-111069-12", "8233-102513-12", "8233-132158-12", "8233-122350-12" ] }, { "id": 7913, "title": { "de": "NeEDs - necessary decision support system", "en": "NeEDs - necessary decision support system" }, "short": "NeEDs", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2023-12-05T10:18:58+01:00", "program": null, "subprogram": null, "organization": 14076, "category": 10, "type": 10, "partner_function": 4, "manager": 78071, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1040 ], "funder_projectcode": "1.000.072.603", "ethics_committee": null, "edudract_number": null, "persons": [ "7913-78071-10" ] }, { "id": 8060, "title": { "de": "Modelling Reproductive Failure with Endometrium-On-A-Chip, acib Projekt ID 98.311", "en": "Modelling Reproductive Failure with Endometrium-On-A-Chip, acib Projekt ID 98.311" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2028-12-31T01:00:00+01:00", "end_effective": "2028-12-31T01:00:00+01:00", "assignment": "2024-03-01T10:42:56+01:00", "program": 94, "subprogram": null, "organization": 14064, "category": 10, "type": 10, "partner_function": 2, "manager": 75380, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8060-75380-10" ] }, { "id": 7917, "title": { "de": "Entwicklung einer Immobilisierungsmethode für ein Compound-Screening basierend auf Fluoreszenzmikroskopie in Fadenwürmern", "en": "Establishing an immobilization method for compound screens based on\r\nfluorescence microscopy in nematodes" }, "short": "Immobilisierung_Compound-Screening_WTZ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2023-12-07T12:13:19+01:00", "program": 207, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 1, "manager": 85069, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7917-85069-10" ] }, { "id": 8142, "title": { "de": "TARgetinG disease pErsisTence and progression of\r\nMyeloProliferative Neoplasms", "en": "TARgetinG disease pErsisTence and progression of\r\nMyeloProliferative Neoplasms" }, "short": "TARGET MPN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-06-01T02:00:00+02:00", "end_planned": "2028-01-01T01:00:00+01:00", "end_effective": "2028-07-10T02:00:00+02:00", "assignment": "2024-04-18T12:35:12+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 107132, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I06944", "ethics_committee": null, "edudract_number": null, "persons": [ "8142-107132-10", "8142-134381-12", "8142-101484-12", "8142-126596-12" ] }, { "id": 8638, "title": { "de": "OptoBioInterface: Lichtaktive Mikropartikel zur Neurostimulation", "en": "OptoBioInterface: Light-Active Microparticles\r\nfor Retinal Neuron Stimulation" }, "short": "OptoBioInterface", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-05-31T02:00:00+02:00", "end_effective": "2026-04-30T02:00:00+02:00", "assignment": "2025-02-03T17:05:19+01:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 3, "manager": 99325, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8638-99325-10" ] }, { "id": 7894, "title": { "de": "Der Einfluss von Typ I Interferon auf die Pathogenese der Riesenzellarteriitis", "en": "Defining the role of the type I interferon pathway in the pathogenesis of giant cell arteritis " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2027-01-01T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2023-11-21T15:06:00+01:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 4, "manager": 117681, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 87 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7894-117681-10" ] }, { "id": 8048, "title": { "de": "Attraktivierung Allgemeinmedizin 4.0", "en": "Making general medicine 4.0 more attractive" }, "short": "Attraktivierung Allgemeinmedizin 4.0", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-02-20T11:30:33+01:00", "program": null, "subprogram": null, "organization": 27964, "category": 10, "type": 10, "partner_function": 3, "manager": 93279, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2160 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8048-93279-10" ] }, { "id": 8144, "title": { "de": "Metabolische Signaturen von T-Zell-Untergruppen als neue diagnostische oder therapeutische Angriffspunkte bei Kollagenose-assoziierten interstitiellen Lungenerkrankungen", "en": "Metabolic signatures of T cell subsets as novel diagnostic or therapeutic\r\ntargets in connective tissue disease-associated interstitial lung disease" }, "short": "T cell metabolism in CTD-ILD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-04-23T17:42:43+02:00", "program": null, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 3, "manager": 95212, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8144-78952-11", "8144-95212-10", "8144-107391-11" ] }, { "id": 7852, "title": { "de": "Ein Stammzellpflaster als Therapiemöglichkeit für Verletzungen der juvenilen Wachstumsfuge", "en": "A stem cell sheet as a therapeutic option for juvenile growth plate injuries" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2026-09-30T02:00:00+02:00", "assignment": "2023-10-24T16:18:54+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 100991, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7852-100991-10" ] }, { "id": 7906, "title": { "de": "INTERACT-EUROPE 100", "en": "INTERACT-EUROPE 100" }, "short": "INTERACT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2023-12-01T01:00:00+01:00", "end_planned": "2026-01-01T01:00:00+01:00", "end_effective": "2026-11-30T01:00:00+01:00", "assignment": "2023-11-28T13:37:15+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 107132, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101129375", "ethics_committee": null, "edudract_number": null, "persons": [ "7906-107132-10" ] }, { "id": 8024, "title": { "de": "Interaktionen von Kaffeesäure mit Nanocellulose", "en": "Interactions of caffeic acid with nanocellulose" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-02-05T15:17:40+01:00", "program": 207, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 113130, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8024-113130-10" ] }, { "id": 8449, "title": { "de": "Biokatalytische Synthese von herausfordernden Makrozyklen\r\n", "en": "Biocatalytic Synthesis of Challenging Macrocycles " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-02-01T01:00:00+01:00", "end_planned": "2027-06-30T02:00:00+02:00", "end_effective": "2027-07-31T02:00:00+02:00", "assignment": "2024-10-16T12:46:55+02:00", "program": 72, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 2, "manager": 107189, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 37113", "ethics_committee": null, "edudract_number": null, "persons": [ "8449-50565-12", "8449-107189-10", "8449-128174-12" ] }, { "id": 8061, "title": { "de": "Modelling Reproductive Failure with Endometrium-On-A-Chip, acib Projekt ID 98.311\r\n", "en": "Modelling Reproductive Failure with Endometrium-On-A-Chip, acib Projekt ID 98.311\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2028-12-31T01:00:00+01:00", "end_effective": "2028-12-31T01:00:00+01:00", 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