Project List
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GET /v1/research/project/?format=api&offset=280&ordering=end_planned
{ "count": 2244, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=300&ordering=end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=260&ordering=end_planned", "results": [ { "id": 2534, "title": { "de": "Bipolar affektive Erkrankung und Schwangerschaft, Geburt und Postpartum", "en": "Bipolar affective disorder in pregnancy and postpartum period" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-01T02:00:00+02:00", "begin_effective": "2011-05-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-09-30T02:00:00+02:00", "assignment": "2011-07-15T14:17:12+02:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": 50654, "contact": 50654, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2534-50654-10" ] }, { "id": 2495, "title": { "de": "Bipolar affektive Erkrankung und Schwangerschaft, Geburt und Postpartum", "en": "Bipolar affektive Erkrankung und Schwangerschaft, Geburt und Postpartum" }, "short": "Bipolar affektive Erkrankungen", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-01T02:00:00+02:00", "begin_effective": "2011-06-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-02-28T01:00:00+01:00", "assignment": "2011-06-10T12:18:59+02:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": 50654, "contact": 50654, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2495-50654-10" ] }, { "id": 2498, "title": { "de": "Die Rolle von Metalloproteasen und Endothelin im ersten Schwangerschaftstrimester", "en": "The role of metalloproteinases and endothelin in the first trimester of pregnancy" }, "short": "METALLPROTEINASES_ENDOTHELIN_PREGNANCY", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2011-06-16T12:49:53+02:00", "program": null, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2043, "title": { "de": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action", "en": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action" }, "short": "ORPHAN RECEPTOR GPR55", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-01-20T12:45:29+01:00", "program": 92, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1734, "title": { "de": "Verkalkung von Gefäßen und Knochen bei NierentransplantationspatientInnen [Regulierung der Kalzifizierung bei NierentransplantationspatientInnen]", "en": "Verkalkung von Gefäßen und Knochen bei NierentransplantationspatientInnen [Regulierung der Kalzifizierung bei NierentransplantationspatientInnen]" }, "short": "Verkalkung bei Nierentransplantationen", "url": null, "abstract": { "de": "Kalzifizierung tritt physiologisch im Knochen und pathophysiologisch im Gefäßsystem auf. Kardiovaskuläre Erkrankungen sind eine Haupt-Todesursache von Nierenerkrankten und sind entscheidend für die Durchführbarkeit von Nierentransplantationen (RTX). Das derezeitige Wissen um die Regulation der Kalzifizierung in Knochen und Gefäßsystem bei RTX-Patienten ist fragmentarisch.\r\n\r\nDiese offene, kontrollierte, monozentrische Studie untersucht die Regulation der Kalzifizierung im Knochen- und Gefäßsystem bei PatientInnen mit RTX.\r\nUnsere Fragestellung zielt auf Unterschiede der Expressionslevels von Regulatoren der Kalzifizierung in beiden Gewebstypen und im Vergleich von athero- und mediasklerotischen Gefäßen.\r\nWir erwarten uns Einblick in Kalzifizierungsmechanismen und mögliche klinische Aspekte für Diagnose und Therapie bei diesen HochrisikopatientInnen.", "en": "Kalzifizierung tritt physiologisch im Knochen und pathophysiologisch im Gefäßsystem auf. Kardiovaskuläre Erkrankungen sind eine Haupt-Todesursache von Nierenerkrankten und sind entscheidend für die Durchführbarkeit von Nierentransplantationen (RTX). Das derezeitige Wissen um die Regulation der Kalzifizierung in Knochen und Gefäßsystem bei RTX-Patienten ist fragmentarisch.\r\n\r\nDiese offene, kontrollierte, monozentrische Studie untersucht die Regulation der Kalzifizierung im Knochen- und Gefäßsystem bei PatientInnen mit RTX.\r\nUnsere Fragestellung zielt auf Unterschiede der Expressionslevels von Regulatoren der Kalzifizierung in beiden Gewebstypen und im Vergleich von athero- und mediasklerotischen Gefäßen.\r\nWir erwarten uns Einblick in Kalzifizierungsmechanismen und mögliche klinische Aspekte für Diagnose und Therapie bei diesen HochrisikopatientInnen." }, "begin_planned": "2009-01-01T01:00:00+01:00", "begin_effective": "2009-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2009-01-21T15:49:20+01:00", "program": 79, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": 51982, "contact": 51982, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1734-51982-10", "1734-57544-12" ] }, { "id": 2023, "title": { "de": "Induction of immunological changes by endoluminal photodynamic therapy (PDT) for esophageal carcinoma", "en": "Induction of immunological changes by endoluminal photodynamic therapy (PDT) for esophageal carcinoma" }, "short": "PDT_ESOPHAGEAL_CARCINOMA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2009-12-18T12:29:42+01:00", "program": 79, "subprogram": null, "organization": 14077, "category": 10, "type": 10, "partner_function": 4, "manager": 51615, "contact": 51615, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2023-62056-12", "2023-51615-10", "2023-51618-12" ] }, { "id": 2097, "title": { "de": "Role of SPN in PP1-mediated RyR2 regulation and intracellular Ca2+ handling", "en": "Role of SPN in PP1-mediated RyR2 regulation and intracellular Ca2+ handling" }, "short": "ROLE OF SPN ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T12:56:38+01:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2384, "title": { "de": "Mobile Teledermatologie in der Behandlung von Akne-Patienten", "en": "Use of Mobile Teledermatology in the Care of Acne Patients" }, "short": "Mobile Acne Care", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-01-01T01:00:00+01:00", "begin_effective": "2011-04-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2011-01-24T15:38:08+01:00", "program": 79, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 51711, "contact": 51711, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2384-51711-10" ] }, { "id": 1716, "title": { "de": "Nano-Health: Nano-structured materials for drug targeting, release and imaging", "en": "Nano-Health: Nano-structured materials for drug targeting, release and imaging" }, "short": "NANO-HEALTH", "url": null, "abstract": { "de": "The increasing incidence of cancer and of degenerative diseases, the latter uncreasingly in relatively young patients, calls for a new healthcare model that is more proactive (detects asymptomatic disease when it is more amenable to treatment), more personalised (based on the growing knowledge about the molecular mechanisms underlying disease), less traumatic and more targeted (non/minimally invasively and specifically treats the affected tissue or organ(s)) and that allows more informed interventions (following of the progress of therapy and disease reoccurrence in as close to real time as possible).\r\nThis prolongation of NANO-HEALTH will build on the work done to date to develop new NM-based solutions for targeted drug delivery and imaging. The following topics will be pursued:\r\n*Further development of thiomers for oral delivery of active substances\r\n*An industrial production process for nano-thiomers\r\n*Development of targeted imaging for cancer using MRI\r\n*Stem cell tracking in vivo\r\n*Atherosclerotic plaque detection\r\n*Chronic nanotoxicity", "en": "The increasing incidence of cancer and of degenerative diseases, the latter uncreasingly in relatively young patients, calls for a new healthcare model that is more proactive (detects asymptomatic disease when it is more amenable to treatment), more personalised (based on the growing knowledge about the molecular mechanisms underlying disease), less traumatic and more targeted (non/minimally invasively and specifically treats the affected tissue or organ(s)) and that allows more informed interventions (following of the progress of therapy and disease reoccurrence in as close to real time as possible).\r\nThis prolongation of NANO-HEALTH will build on the work done to date to develop new NM-based solutions for targeted drug delivery and imaging. The following topics will be pursued:\r\n*Further development of thiomers for oral delivery of active substances\r\n*An industrial production process for nano-thiomers\r\n*Development of targeted imaging for cancer using MRI\r\n*Stem cell tracking in vivo\r\n*Atherosclerotic plaque detection\r\n*Chronic nanotoxicity" }, "begin_planned": "2009-01-01T01:00:00+01:00", "begin_effective": "2009-03-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-02-28T01:00:00+01:00", "assignment": "2009-01-14T14:15:30+01:00", "program": null, "subprogram": "Nano-Initiative", "organization": 28392, "category": 10, "type": 10, "partner_function": 2, "manager": 54033, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1716-54033-10" ] }, { "id": 2192, "title": { "de": "Akupressur-Stimulationsequipment zur emotionalen Entlastung von Menschen mit geistiger Behinderung", "en": "Akupressur-Stimulationsequipment zur emotionalen Entlastung von Menschen mit geistiger Behinderung" }, "short": "AKUPRESSUR_STIMULATION", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2010-05-03T14:28:49+02:00", "program": null, "subprogram": null, "organization": 14044, "category": 10, "type": 10, "partner_function": 4, "manager": 51073, "contact": 51073, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2192-51073-10" ] }, { "id": 2093, "title": { "de": "Isolation of Side Population Cells in Human Soft Tissue Sarcomas", "en": "Isolation of Side Population Cells in Human Soft Tissue Sarcomas" }, "short": "ISOLATION OF SIDE POP CELLS ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T12:52:51+01:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50696, "contact": 50696, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2093-50696-10" ] }, { "id": 1996, "title": { "de": "Disturbed Lipid Metabolism in Gestational Diabetes - Culprit of Fetal Adverse Outcome", "en": "Disturbed Lipid Metabolism in Gestational Diabetes - Culprit of Fetal Adverse Outcome" }, "short": "DISTURBED LIPID METABOLISM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2009-11-30T14:36:35+01:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 52569, "contact": 52569, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 151 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1996-52569-10" ] }, { "id": 1204, "title": { "de": "Graz als Forschungszentrum für Traditionelle Chinesische Medizin ", "en": "Graz als Forschungszentrum für Traditionelle Chinesische Medizin" }, "short": "GRAZ_FORSCHUNGSZENTRUM_TCM", "url": null, "abstract": { "de": "Das große Interesse der Menschen an komplementärmedizinischen Methoden unterstreicht die Notwendigkeit, dass sich die universitäre Forschung noch intensiver mit der Traditionellen Chinesischen Medizin (TCM) auseinander setzt. Unter der Initiative Grazer Wissenschaftler der Medizinischen Universität und der Karl-Franzens-Universität sowie unter Miteinbeziehung zahlreicher \"collaborative partners\" soll versucht werden, ein Interuniversitäres Forschungszentrum für TCM in Graz zu etablieren. Hauptziel des Projektes ist es, die TCM nach streng naturwissenschaftlichen Methoden zu erforschen und damit eine klare Abgrenzung zu dogmatischen Sichtweisen zu erreichen. Mit den Forschungstätigkeiten des geplanten Zentrums soll durch einen Brückenschlag zwischen östlicher und westlicher Medizin die naturwissenschaftliche Entmysitifizierung der TCM für die Zukunft untermauert werden.", "en": "Das große Interesse der Menschen an komplementärmedizinischen Methoden unterstreicht die Notwendigkeit, dass sich die universitäre Forschung noch intensiver mit der Traditionellen Chinesischen Medizin (TCM) auseinander setzt. Unter der Initiative Grazer Wissenschaftler der Medizinischen Universität und der Karl-Franzens-Universität sowie unter Miteinbeziehung zahlreicher \"collaborative partners\" soll versucht werden, ein Interuniversitäres Forschungszentrum für TCM in Graz zu etablieren. Hauptziel des Projektes ist es, die TCM nach streng naturwissenschaftlichen Methoden zu erforschen und damit eine klare Abgrenzung zu dogmatischen Sichtweisen zu erreichen. Mit den Forschungstätigkeiten des geplanten Zentrums soll durch einen Brückenschlag zwischen östlicher und westlicher Medizin die naturwissenschaftliche Entmysitifizierung der TCM für die Zukunft untermauert werden." }, "begin_planned": "2007-01-01T01:00:00+01:00", "begin_effective": "2007-03-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2009-08-31T02:00:00+02:00", "assignment": "2007-03-30T14:54:07+02:00", "program": 75, "subprogram": "MUG ist gleichberechtigter Projektpartner", "organization": 14044, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 55 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1204-54121-12" ] }, { "id": 2340, "title": { "de": "Die Bedeutung des gluconeogenetischen Enzyms Phosphoenolpyruvat Carboxykinase (PEPCK) für das Tumorwachstum", "en": "The role of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) in cancer growth" }, "short": "PEPCK", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-09-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2010-11-17T10:58:29+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 57557, "contact": 57557, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2340-57557-10" ] }, { "id": 2031, "title": { "de": "Genetic variants in the RAD51, BRCA1 and BRCA2 genes as predictors of radiation response and toxicity in prostate cancer patients", "en": "Genetic variants in the RAD51, BRCA1 and BRCA2 genes as predictors of radiation response and toxicity in prostate cancer patients" }, "short": "GENETIC_PROSTATE_CANCER_OeNB", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-01-11T15:12:11+01:00", "program": 79, "subprogram": null, "organization": 14060, "category": 10, "type": 10, "partner_function": 4, "manager": 50495, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2031-50495-10", "2031-50910-12" ] }, { "id": 2550, "title": { "de": "Endothelin und Matrixmetalloproteinasen im ersten Schwangerschaftstrimester", "en": "Endothelin and matrix metalloproteinases in the first trimester of pregnancy" }, "short": "EndothelMatrix", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-08-01T02:00:00+02:00", "begin_effective": "2011-08-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2011-08-02T14:12:12+02:00", "program": null, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2609, "title": { "de": "Hepcidin im Rahmen von Sepsis und Adipositas", "en": "The Role of Hepcidin in Sepsis and Obesity" }, "short": "HEPCIDIN_SEPSIS_ADIPOSITAS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2011-10-06T15:38:08+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 50778, "contact": 50778, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2609-50778-10" ] }, { "id": 2095, "title": { "de": "Purkinje Topology", "en": "Purkinje Topology" }, "short": "PURKINJE TOPOLOGY", "url": null, "abstract": { "de": "Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. ", "en": "Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. " }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T12:53:47+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 50967, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2095-50967-10" ] }, { "id": 2090, "title": { "de": "Expression profiling in hypoxic non-small cell lung cancer", "en": "Expression profiling in hypoxic non-small cell lung cancer" }, "short": "NON-SMALL CELL LUNG CANCER ", "url": null, "abstract": { "de": "Das Bronchialkarzinom ist nach wie vor die führende Krebstodesursache weltweit. 80% sind sogenannte Nicht-kleinzellige Bronchialkarzinome (non-small cell lung cancers, NSCLC). Das Gesamtüberleben der Patienten mit NSCLC ist schlecht, trotz der derzeit vorhandenen Therapieoptionen, zum Teil wegen Resistenz gegenüber Radio- und Chemotherapie. Tumorhypoxie (verminderte Sauerstoffzufuhr im Tumor) induziert in den Tumorzellen Adaptationsvorgänge und ist zum Teil für die Therapieresistenz verantwortlich. Die genauen Mechanismen sind jedoch nicht bekannt. Unser neu etabliertes ex-vivo Modell der hypoxischen Adaptation beim NSCLC, welches auf der Verwendung von kleinsten NSCLC Fragmenten aus Operationsmaterial beruht, ist geignet, um die Vorgänge im Tumor unter hypoxischen Bedingungen zu untersuchen. Das Ziel der vorliegenden Studie ist, die Genexpressionsmuster der in Hypoxie bzw unter normalen Sauerstoffbedingungen kultivierten NSCLC Fragmente zu vergleichen. Die differenziell regulierten Gene werden dafür mittels cDNA microarrays bestimmt. Die Ergebnisse werden in nachfolgenden Einzelgen-Polymerase Kettenreaktionen validiert. Unsere Studie könnte somit das Verständnis der Pathomechanismen beim Tumorwachstum verbessern und mögliche neue Therapieoptionen beim NSCLC aufzeigen.", "en": "Lung cancer is the leading cause of cancer deaths overall in the world. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancers. Overall survival is poor, in part due to resistance to chemotherapy and radiotherapy. Intratumoral hypoxia (limited oxygen supply) frequently occurs in solid tumors, such as NSCLC. Hypoxia initiates adaptive responses in tumor cells and was shown to induce chemotherapy resistance and promote aggressive tumor growth. The mechanisms of hypoxia-induced adaptive responses in solid tumors are not fully elucidated, yet. We established an ex-vivo model for hypoxic adaptation using NSCLC surgery fragments. The fragments are maintained in short-time culture in hypoxia or ambient oxygen (normoxia) without significant loss of viability or increase in apoptosis and display significant induction of carbonic anhydrase IX, a marker for tumor hypoxia, under hypoxic conditions. The aim of the current study is to analyze hypoxia-induced gene expression changes using cDNA microarrays and consecutive single gene real-time polymerase chain reaction (RT-PCR) on hypoxic vs. normoxic NSCLC fragments, in order to identify genes that are consistently induced or suppressed in hypoxia. Our study thus provides a novel approach to identify molecular pathways that are crucial for hypoxic adaptive changes in NSCLC and might represent targets for therapy." }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T11:39:13+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 57557, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2090-57557-10" ] }, { "id": 1821, "title": { "de": "Nano-Health: Nano-Plaque-Extension", "en": "Nano-Health: Nano-Plaque-Extension" }, "short": "Nano-Plaque-Extension", "url": null, "abstract": { "de": "The increasing incidence of cancer and of degenerative diseases, the latter increasingly in relatively young patientes, call for a new healthcare model that is more proactive, i.e. that detects disease pre-symptomatically when it is more amenable to treatment, more personalised, i.e. based on the growing knowledge about the molecular mechanisms underlying disease, less traumatic and more targeted, i.e. that non-invasively or minimally invasively and specifically treats the affected tissue or organ(s) and allows more informed interventions, i.e. That enables the progress of therapy and relapse to be followed in as close to real time as possible.\r\nThe extended project will build on the achievements of NANO-HEALTH made to date. Within the first two years an NP platform based on 4 different types of NPs was elaborated and optimised for drug delivery and imaging. All NPs were characterised in detail by physico-chemical and chemical methods. Starting from this platform, the most promising NPs were optimised for oral drug delivery, for a depot formulation of Vasoactive Intestinal Peptide (VIP), for contrast media using MRI and Spect/PET and to trace stem cells in vivo and for the early detection of atherosclerotic plaque. Several proof-of-concept studies were performed from the end of year 2 up to now (3 years and 3 months).\r\n\r\nThe prolongation of NANO-HEALTH year 5 to 7 will build on the work done to date to develop new NM-based solutions for targeted drug delivery and imaging. The following topics will be pursued:\r\n*Further development of thiomers for oral and topical (depot)delivery of active substances\r\n*(Based on the successful results obtained so far) large scale production processes for nano-thiomers and PLA-HSA-based NPs\r\n*Development of targeted imaging for cancer using MRI\r\n*Stem cell tracking in vivo\r\n*Atherosclerotic plaque detection\r\n*Chronic nanotoxicity", "en": "The increasing incidence of cancer and of degenerative diseases, the latter increasingly in relatively young patientes, call for a new healthcare model that is more proactive, i.e. that detects disease pre-symptomatically when it is more amenable to treatment, more personalised, i.e. based on the growing knowledge about the molecular mechanisms underlying disease, less traumatic and more targeted, i.e. that non-invasively or minimally invasively and specifically treats the affected tissue or organ(s) and allows more informed interventions, i.e. That enables the progress of therapy and relapse to be followed in as close to real time as possible.\r\nThe extended project will build on the achievements of NANO-HEALTH made to date. Within the first two years an NP platform based on 4 different types of NPs was elaborated and optimised for drug delivery and imaging. All NPs were characterised in detail by physico-chemical and chemical methods. Starting from this platform, the most promising NPs were optimised for oral drug delivery, for a depot formulation of Vasoactive Intestinal Peptide (VIP), for contrast media using MRI and Spect/PET and to trace stem cells in vivo and for the early detection of atherosclerotic plaque. Several proof-of-concept studies were performed from the end of year 2 up to now (3 years and 3 months).\r\n\r\nThe prolongation of NANO-HEALTH year 5 to 7 will build on the work done to date to develop new NM-based solutions for targeted drug delivery and imaging. The following topics will be pursued:\r\n*Further development of thiomers for oral and topical (depot)delivery of active substances\r\n*(Based on the successful results obtained so far) large scale production processes for nano-thiomers and PLA-HSA-based NPs\r\n*Development of targeted imaging for cancer using MRI\r\n*Stem cell tracking in vivo\r\n*Atherosclerotic plaque detection\r\n*Chronic nanotoxicity" }, "begin_planned": "2009-03-01T01:00:00+01:00", "begin_effective": "2009-03-01T01:00:00+01:00", "end_planned": "2012-01-28T01:00:00+01:00", "end_effective": "2012-02-28T01:00:00+01:00", "assignment": "2009-05-18T13:05:25+02:00", "program": null, "subprogram": "Nano-Health Verlängerung", "organization": 14028, "category": 10, "type": 10, "partner_function": 2, "manager": 52854, "contact": 52854, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1821-52854-10" ] } ] }