Project List
List projects.
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GET /v1/research/project/?format=api&offset=280&ordering=-end_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=300&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=260&ordering=-end_effective", "results": [ { "id": 7739, "title": { "de": "Evaluierung innovativer molekularer Analyseverfahren und -ansätze zur Überwachung von Antibiotikaresistenzen im Abwasser", "en": "Evaluation of innovative molecular analytical methods and approaches for monitoring antibiotic resistance in wastewater" }, "short": "ARISE", "url": null, "abstract": { "de": "Universelle DNA/RNA Diagnostik. Es soll die technische Realisier- und Leistungsfähigkeit einer neuen universell einsetzbaren molekularbiologischen Nachweisstrategie für die robuste und sensitive DNA/RNA-Diagnostik biologischer („emerging“) Gefährdungen aller Art für das Abwassermonitoring von Morgen demonstriert werden. Dies wird am Beispiel bakterieller Antibiotikaresistenzen (ARB) – auf Basis einer zukunftsweisenden neuartigen molekularbiologischen Toolbox – durchgeführt. Einerseits stellt die ARB-Problematik eine der größten zukünftigen medizinischen globalen Herausforderungen dar (= größte Relevanz), andererseits sind bereits neue leistungsfähige methodische Teillösungen vorhanden, die in kurzer Zeit zur vorgeschlagenen Toolbox kombiniert werden können (= schnelle Umsetzbarkeit). Da diese auf einer Analyse genetischer Sequenzen basiert, ist eine schnelle Ausweitung auf andere biologische Gefährdungen möglich (nach Anpassung der Sampling- und Probenaufarbeitung).\r\nWasserkreislauf-basierter Ansatz. Die vorgeschlagene Nachweisstrategie soll darüber hinaus erstmals simultane Rückschlüsse auf, i) Verbreitung und Infektionsprävalenz des überwachten Bevölkerungskollektivs im Einzugsgebiet der Abwasserentsorgung (d.h. eigentliche Abwasser-epidemiologie - „Upstream-Verfahren“), als auch, ii) die Gefährdung für Mensch- und Natur (z.B. Nutzung als Badewässer, Trinkwasser oder Fischereigewässer) im Zuge der Ausbreitung über den nachgeschalteten Vorfluter und Wasserkreislauf, ermöglichen (d.h. nutzungsbasierte Gefährdungs- und Risikoanalyse der beeinflussten Wasserressource). \r\nOne-Health Monitoring & Management. Da ARB – wie auch viele andere biologische Gefährdungen – humanen und tierischen Ursprung haben und beidseitige Relevanz besitzen können, wird das vorgeschlagene Tool auf alle Arten fäkaler Abwässer entwickelt und ermöglicht eine Zuordnung und Differenzierung (molekulares fäkales Source-Tracking). Dadurch wird eine universell anwendbare Toolbox im Sinne eines One-Health Ansatzes ermöglicht.\r\nBis Dato vorhandene Limitierungen. Verfügbare molekularbiologische Anwendungen sind i.d.R. i) sensitiv und spezifisch, aber auf wenige Targets beschränkt (z.B. qPCR, RT-qPCR), oder, ii) universell, auf viele Targets einsetzbar, aber wenig sensitiv (z.B. gängige Hochdurchsatz-Sequenzierungsmethoden). Zum anderen erfolgt der Nachweis biologischer Gefährdungen im Abwasser bislang weitgehend ohne Berücksichtigung der Quantität und Qualität der fäkalen Belastungssituation (d.h. Ausmaß, Charakteristik und Herkunft der fäkalen mikrobiologischen Beeinflussung).\r\n", "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2023-08-29T16:37:42+02:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 2, "manager": 58733, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "FO999905348", "ethics_committee": null, "edudract_number": null, "persons": [ "7739-54018-11", "7739-58733-10", "7739-103077-12" ] }, { "id": 7415, "title": { "de": "Magnetischer Stein", "en": "Magnetic Stone" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-02-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2023-02-23T09:38:55+01:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 4, "manager": 113130, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-87", "ethics_committee": null, "edudract_number": null, "persons": [ "7415-113130-10" ] }, { "id": 7933, "title": { "de": "INTERnational Cooperation of high containment research infrastructures: from Epidemic Preparedness TO\r\nResponse", "en": "INTERnational Cooperation of high containment research infrastructures: from Epidemic Preparedness TO\r\nResponse" }, "short": "INTERCEPTOR", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-09-01T02:00:00+02:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2026-08-31T02:00:00+02:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2023-12-15T12:06:13+01:00", "program": 210, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7933-51663-10" ] }, { "id": 6015, "title": { "de": "CETOCOEN Excellence", "en": "CETOCOEN Excellence" }, "short": "CETOCOEN Excellence", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-01-01T01:00:00+01:00", "begin_effective": "2020-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2020-01-07T14:17:10+01:00", "program": 109, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 51449, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6015-51449-10", "6015-99976-12", "6015-133220-12" ] }, { "id": 7271, "title": { "de": "DIOPTRA - Früherkennung von neuen Initiationsmechanismus-Protein-Biomarkern bei Darmkrebs ", "en": "DIOPTRA - Early Dynamic Screening for Colorectal Cancer via Novel Protein Biomarkers Reflecting Biological Initiation Mechanisms" }, "short": "DIOPTRA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2022-11-29T13:54:01+01:00", "program": 219, "subprogram": null, "organization": 28392, "category": 10, "type": 10, "partner_function": 4, "manager": 98966, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101096649", "ethics_committee": null, "edudract_number": null, "persons": [ "7271-98966-10" ] }, { "id": 8636, "title": { "de": "LUMES: Lichtaktive Mikropartikel bei degnerativen Augenerkrankungen", "en": "LUMES: Light-Utilizing Microparticles for Eye Sight" }, "short": "LUMES:", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2025-02-03T14:38:00+01:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 3, "manager": 99325, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8636-99325-10" ] }, { "id": 9270, "title": { "de": "Strukturiertes Kommunikationstraining mit standardisierten Patient*innen für die antenatale neonatologische Beratung bei drohender Frühgeburt", "en": "Antenatal Counselling Training for expected preterm delivery using structured communication training with standardized patients" }, "short": "ACT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2025-10-15T18:28:23+02:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 1, "manager": 68534, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 97 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9270-68534-10" ] }, { "id": 9710, "title": { "de": "Aufbau und wissenschaftliche Begleitung eines Modells zur Versorgung von Typ-2-Diabetikern im niedergelassenen Bereich der Pflege mit digitaler Entscheidungsunterstützung", "en": "Development and scientific evaluation of a model for the care of patients with type 2 diabetes in outpatient nursing, supported by digital clinical decision support" }, "short": "DigiDiab-2", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2026-03-27T10:31:34+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 3, "manager": 65558, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2160 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9710-65558-10" ] }, { "id": 8929, "title": { "de": "Anatomisches Erbe: Unseren Vergangenheit digital bewahren, Unsere Zukunft sichern", "en": "ANATOMICAL LEGACY: DIGITALLY PRESERVING OUR PAST, SECURING OUR FUTURE" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-04-01T02:00:00+02:00", "begin_effective": "2025-06-01T02:00:00+02:00", "end_planned": "2026-01-12T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2025-05-23T11:40:55+02:00", "program": 207, "subprogram": null, "organization": 14018, "category": 10, "type": 10, "partner_function": 1, "manager": 102804, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8929-97024-12", "8929-102804-10" ] }, { "id": 5704, "title": { "de": "Probiotische Modulation der Darmflora in PatientInnen mit Leberzirrhose und Lanzeiteinnahme von Protonenpumpenhemmer", "en": "Probiotic modulation of intestinal microbiota of cirrhotic patients with long-term PPI use " }, "short": "PPI-PRB", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-06-01T02:00:00+02:00", "begin_effective": "2019-03-01T01:00:00+01:00", "end_planned": "2019-05-31T02:00:00+02:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2019-02-20T10:12:04+01:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 81091, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-41", "ethics_committee": null, "edudract_number": null, "persons": [ "5704-81091-10" ] }, { "id": 9252, "title": { "de": "Magnetische Analyse von Biomarkern", "en": "Magnetic Analysis of Biomarkers" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-01-01T01:00:00+01:00", "begin_effective": "2026-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2025-10-03T11:02:07+02:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 4, "manager": 113130, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9252-113130-10" ] }, { "id": 5742, "title": { "de": "Untersuchungen zur Rolle von cholestase-induzierter Thrombozytenaktivierung in der Pathogenese cholestatischer Lebererkrankungen", "en": "Investigating the role of cholestasis induced platelet activation in the pathogenesis of cholestatic liver injury. " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-02-01T01:00:00+01:00", "begin_effective": "2019-02-01T01:00:00+01:00", "end_planned": "2020-01-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2019-03-25T09:23:29+01:00", "program": null, "subprogram": null, "organization": 14091, "category": 10, "type": 10, "partner_function": 4, "manager": 62201, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-40", "ethics_committee": null, "edudract_number": null, "persons": [ "5742-62201-10" ] }, { "id": 8463, "title": { "de": "Fortschritte in der Sepsiserkennung: Fortschrittliche magnetischen Anreicherung für eine frühere Diagnose", "en": "Advancing sepsis detection: Pioneering magnetic enrichment for earlier diagnosis" }, "short": "SEPMAG", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-10-23T11:36:06+02:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 4, "manager": 124253, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 35 ], "funder_projectcode": "EI 1326/1-1", "ethics_committee": null, "edudract_number": null, "persons": [ "8463-124253-10" ] }, { "id": 4802, "title": { "de": "Sarkomforschung", "en": "sarcoma research" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2018-01-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2017-02-02T12:27:48+01:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50696, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-17", "ethics_committee": null, "edudract_number": null, "persons": [ "4802-50696-10" ] }, { "id": 8107, "title": { "de": "Accelerating datafication for support of EU health priorities, greening of biobanks and integrated approach to “One Health”", "en": "Accelerating datafication for support of EU health priorities, greening of biobanks and integrated approach to “One Health”" }, "short": "EvolveBBMRI", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-09-01T02:00:00+02:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2026-08-31T02:00:00+02:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-03-22T10:41:14+01:00", "program": 210, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8107-51663-10" ] }, { "id": 8573, "title": { "de": "Integrierter Ansatz zur Gewebsheilung: Ein bioaktives magnetisches Pflaster mit Hyperthermie und immobilisiertem Humanserumalbumin", "en": "Integrative approach to tissue healing: A bioactive magnetic patch with hyperthermia and immobilized human serum albumin" }, "short": "BIMA-Patch", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-12-19T15:25:02+01:00", "program": 207, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 124253, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "BA 07/2025", "ethics_committee": null, "edudract_number": null, "persons": [ "8573-124253-10" ] }, { "id": 8117, "title": { "de": "Bessere Blutgefäße: Elektrogesponnene Gerüste aus humanen Proteinen.", "en": "Building Better Blood Vessels: Human Protein Electrospun Scaffolds in Tissue Engineering." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-06-01T02:00:00+02:00", "begin_effective": "2024-06-01T02:00:00+02:00", "end_planned": "2026-07-01T02:00:00+02:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-03-26T10:44:39+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 76930, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8117-76930-10" ] }, { "id": 8572, "title": { "de": "Biologische Chelatbildner zur Behandlung von Metallionenüberladung: Eine vergleichende Studie mit traditionellen chemischen Chelatoren", "en": "Biological chelation agents for metal ion overload: A comparative study\r\nwith traditional chemical chelators" }, "short": "Bio-Chem-Chel ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-12-19T14:55:05+01:00", "program": 203, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 3, "manager": 124253, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "ASEA 11/2024", "ethics_committee": null, "edudract_number": null, "persons": [ "8572-124253-10" ] }, { "id": 8503, "title": { "de": "„Mikroperfusion der Haut zur Bestimmung von Veränderungen des Mikromilieus der Haut bei SSc“", "en": "Dermal open flow microperfusion to determine changes in the skin microenvironment in vivo during SSc" }, "short": "SSc_OFM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-11-01T01:00:00+01:00", "begin_effective": "2024-11-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-11-19T13:55:23+01:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 1, "manager": 120271, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2296 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8503-120271-10" ] }, { "id": 8140, "title": { "de": "Entschlüsselung von Alzheimer: \r\nTRPC1 als zentrale Figur bei Protein-Entfaltung und Cholesterin-Biosynthese\r\n", "en": "Deciphering Alzheimer's: \r\nTRPC1 as a central player in protein unfolding and cholesterol biosynthesis" }, "short": null, "url": null, "abstract": { "de": "Hintergrund: Die Alzheimer-Krankheit (AD) ist eine irreversible und tödliche Form von Demenz, unterteilt in sporadische (SAD) und familiäre AD (FAD). FAD, mit frühem Beginn aufgrund spezifischer Genmutationen, steht im Gegensatz zu SAD, das einen späten Beginn und eine unklare Ursache aufweist. Die Ca2+-Homöostase- Hypothese von SAD legt nahe, dass eine frühzeitige Ca2+-Dysregulation mit der Fehlfaltung von Proteinen und der Anreicherung von Cholesterin einhergeht. Das endoplasmatische Retikulum (ER) ist entscheidend für die Regulation des intrazellulären Ca2+, die Verarbeitung von Proteinen und die Lipid-Biosynthese. Die Familie der transienten Rezeptorpotenzial-Kanäle (TRPC1-7) umfasst TRPC1, der im Hippocampus stark exprimiert wird. Während TRPC2-7 ausschließlich in der Plasmamembran gefunden werden, befindet sich TRPC1 auch in der ER- Membran.\r\nHypothese: TRPC1 könnte an der Regulation von Ca2+, der Synthese von Proteinen und Cholesterin im ER beteiligt sein.\r\nErgebnisse: Vorläufige Experimente zeigten, dass TRPC1 den Ca2+-Leck aus dem ER signifikant verstärkte, den Cholesterinspiegel in TRPC1-transfizierten HEK293-Zellen erhöhte, den Cholesterinspiegel in den Hippocampi transgener Mäuse im Alter veränderte und die Expression von Transkriptionsfaktoren beeinflusste, die an der Proteinfaltung beteiligt sind.\r\nFazit: Eine weitere Erforschung der Rolle von TRPC1 im ER könnte ihn als potenzielles pharmazeutisches Ziel in der AD-Behandlung etablieren.", "en": "Background: Alzheimer’s disease (AD) is an irreversible and fatal form of dementia, divided into sporadic (SAD) and familial AD (FAD). FAD, with early onset due to specific gene mutations, contrasts SAD, with late onset and an unclear cause. The Ca2+ homeostasis hypothesis of SAD suggests early Ca2+ dyshomeostasis links to protein misfolding and cholesterol accumulation. The endoplasmic reticulum (ER) is crucial, managing intracellular Ca2+, protein processing, and lipid biosynthesis. The transient receptor potential canonical family (TRPC1-7) includes TRPC1, highly expressed in the hippocampus. While TRPC2-7 target the plasma membrane, TRPC1 is also found in the ER membrane.\r\nHypothesis: TRPC1 may be involved in Ca2+ handling, protein, and cholesterol synthesis in the ER.\r\nResults: Preliminary experiments showed TRPC1 increased Ca2+ leak from the ER, elevated cholesterol in TRPC1- transfected HEK293 cells, altered cholesterol levels in hippocampi from aged transgenic mice, and affected expression of transcription factors involved in protein folding.\r\nConclusion: Further exploring TRPC1 role in the ER could establish it as a potential pharmaceutical target in AD treatment." }, "begin_planned": "2024-03-01T01:00:00+01:00", "begin_effective": "2024-03-01T01:00:00+01:00", "end_planned": "2025-02-28T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-04-16T14:17:18+02:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 90337, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8140-90337-10", "8140-116421-12", "8140-122690-12" ] } ] }