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GET /v1/research/project/?format=api&offset=280&ordering=-begin_planned
{ "count": 2244, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=300&ordering=-begin_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=260&ordering=-begin_planned", "results": [ { "id": 8585, "title": { "de": "AKUTE EFFEKTE UND VERTRÄGLICHKEIT VON TRAININGSBELASTUNGEN BEI LUNGENKREBSPATIENTINNEN UNTER IMMUNTHERAPIE", "en": "ACUTE EFFECTS AND TOLERABLITY OF EXERCISE IN LUNG CANCER PATIENTS UPON IMMUNOTHERAPY" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-02-01T01:00:00+01:00", "begin_effective": "2025-02-01T01:00:00+01:00", "end_planned": "2026-02-01T01:00:00+01:00", "end_effective": "2026-02-01T01:00:00+01:00", "assignment": "2025-01-07T16:03:50+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 1, "manager": 71794, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": "2024 - FB Wissenschaft 10_24", "ethics_committee": null, "edudract_number": null, "persons": [ "8585-71794-10" ] }, { "id": 8609, "title": { "de": "Exogene eletrische und mechanische Stimulation durch eletronische Haut stimuliert die Zellprofileration der oralen Mundschleimhaut", "en": "Exogenous electrical and mechanical motion stimulation by using an electronic skin for support oral cell proliferation." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-02-01T01:00:00+01:00", "begin_effective": "2025-06-01T02:00:00+02:00", "end_planned": "2028-01-31T01:00:00+01:00", "end_effective": "2028-05-31T02:00:00+02:00", "assignment": "2025-01-21T17:58:12+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 133140, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "ESP6372324", "ethics_committee": null, "edudract_number": null, "persons": [ "8609-133140-10" ] }, { "id": 8589, "title": { "de": "Rejuvenated yeasts for better biorefineries", "en": "Rejuvenated yeasts for better biorefineries" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-31T01:00:00+01:00", "begin_effective": "2025-01-31T01:00:00+01:00", "end_planned": "2028-01-30T01:00:00+01:00", "end_effective": "2028-01-30T01:00:00+01:00", "assignment": "2025-01-10T10:29:19+01:00", "program": 94, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 113130, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8589-113130-10", "8589-132237-12" ] }, { "id": 8707, "title": { "de": "Pilotprojekt: 5 Präventionsfaktoren der Grazer Gehirngesundheit", "en": "Pilot project: 5 Preventive Factors of brain health" }, "short": "5P_3G", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-27T01:00:00+01:00", "begin_effective": "2025-01-27T01:00:00+01:00", "end_planned": "2026-01-27T01:00:00+01:00", "end_effective": "2026-01-27T01:00:00+01:00", "assignment": "2025-03-04T18:18:04+01:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 66708, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8707-66708-10" ] }, { "id": 9076, "title": { "de": "MetAGE: Metabolische Kontrolle von Altern & Krankheit (Zusatzfinanzierung des FWF-geförderten Cluster of Excelence; CoE14)", "en": "MetAGE: Metabolische Kontrolle von Altern & Krankheit (Zusatzfinanzierung des FWF-geförderten Cluster of Excelence; CoE14)" }, "short": "MetAGE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2025-07-07T18:11:47+02:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 91207, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9076-91207-10" ] }, { "id": 8189, "title": { "de": "Orphan Device für pädiatrische Patienten: eine einzigartige Plattform mit innovativen Dienstleistungen", "en": "Orphan Device for paediatric patients: a unique platform providing innovative services" }, "short": "OrphaDev4kids", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2028-01-01T01:00:00+01:00", "end_effective": "2027-06-30T02:00:00+02:00", "assignment": "2024-05-08T10:42:03+02:00", "program": null, "subprogram": "EU4H-2023-PJ", "organization": 14052, "category": 10, "type": 10, "partner_function": 2, "manager": 50785, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101161377", "ethics_committee": null, "edudract_number": null, "persons": [ "8189-50785-10" ] }, { "id": 8635, "title": { "de": "Untersuchung der Pathologie pustulöser Hautkrankheiten: Integration von Spatial Transcriptomics und In-situ-Analysen von seltenen Krankheiten", "en": "Deciphering Pustular Skin Disease Pathology: Integrating Spatial Transcriptomics and In Situ Analysis of rare diseases " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2025-02-03T14:35:54+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 88082, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8635-88082-10" ] }, { "id": 8316, "title": { "de": "Uterine Trophoblasteninvasion: Ein mastrixbasiertes 3D-Gefäßmodel zur \r\nCharakterisierung schwangerschaftsassozierter Erkrankungen", "en": "Uterine trophoblast invasion: A mastrix-based 3D vascular model for the characterization of pregnancy-associated diseases" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-07-29T15:26:52+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 76930, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8316-76930-10", "8316-97931-11" ] }, { "id": 9505, "title": { "de": "RefBurn - Tabellarischer Atlas der Verbrennungstiefe", "en": "RefBurn - A Systematic Catalog of Burn Depths" }, "short": "RefBurn", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2025-12-17T16:26:00+01:00", "program": null, "subprogram": null, "organization": 14076, "category": 10, "type": 10, "partner_function": 1, "manager": 124934, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9505-124934-10" ] }, { "id": 8395, "title": { "de": "Identifying novel lung cancer drivers: Unravelling the functional role of genes affected by large copy number gains\r\n", "en": "Identifying novel lung cancer drivers: Unravelling the functional role of genes affected by large copy number gains\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-09-23T13:30:15+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 109002, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1888 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8395-98327-12", "8395-109501-11", "8395-111070-11", "8395-109002-10", "8395-134203-12" ] }, { "id": 8761, "title": { "de": "Innovative Ansätze für die Implantationsforschung in Gesundheit und Krankheit", "en": "Innovative approaches to implantation research in health and disease" }, "short": "IMPLANTEU", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2028-09-30T02:00:00+02:00", "assignment": "2025-04-09T16:15:10+02:00", "program": 209, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 1, "manager": 53232, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101169308", "ethics_committee": null, "edudract_number": null, "persons": [ "8761-53232-10" ] }, { "id": 8317, "title": { "de": "Neurofilamente im Kammerwasser von Glaukompatient*innen", "en": "Neurofilaments in the Aqueous Humor of Glaucoma Patients" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2024-09-01T02:00:00+02:00", "end_planned": "2026-01-01T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-07-31T14:56:00+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": 89577, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 938 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8317-89577-10" ] }, { "id": 8532, "title": { "de": "Identifizierung Glykosylierungs-bezogener Biomarker\r\nzur Stratifizierung des Schweregrads beim chronischen Fatigue Syndrom", "en": "Exploring the Glycome: Identifying Glycosylation-Related Biomarkers\r\nfor severity stratification in Chronic Fatigue Syndrome" }, "short": "GlycoExplore-CFS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-02-28T01:00:00+01:00", "assignment": "2024-11-27T12:11:08+01:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 1, "manager": 120271, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1844 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8532-120271-10" ] }, { "id": 8544, "title": { "de": "Verbindungen zwischen Aggression, Genetik und Mikrobiom", "en": "Genetic and microbial effects on aggressive behavior" }, "short": "Genetics_microbiome_aggressive behavior", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-03-01T01:00:00+01:00", "end_planned": "2029-01-01T01:00:00+01:00", "end_effective": "2029-02-28T01:00:00+01:00", "assignment": "2024-12-09T13:03:47+01:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 71386, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT5589324", "ethics_committee": null, "edudract_number": null, "persons": [ "8544-71386-10" ] }, { "id": 8459, "title": { "de": "Succinat als Signalmolekül in der menschlichen Plazenta", "en": "Succinate as Signaling Molecule in the human Placenta" }, "short": "Succinat_Signalmolekül_menschlPlazenta", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2024-12-01T01:00:00+01:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2027-11-30T01:00:00+01:00", "assignment": "2024-10-21T11:54:18+02:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 51756, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT8808224", "ethics_committee": null, "edudract_number": null, "persons": [ "8459-51756-10", "8459-100879-11", "8459-106867-12", "8459-111587-12", "8459-132258-12" ] }, { "id": 8463, "title": { "de": "Fortschritte in der Sepsiserkennung: Fortschrittliche magnetischen Anreicherung für eine frühere Diagnose", "en": "Advancing sepsis detection: Pioneering magnetic enrichment for earlier diagnosis" }, "short": "SEPMAG", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-10-23T11:36:06+02:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 4, "manager": 124253, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 35 ], "funder_projectcode": "EI 1326/1-1", "ethics_committee": null, "edudract_number": null, "persons": [ "8463-124253-10" ] }, { "id": 8362, "title": { "de": "MEK Inhibition bei RAS-mutierter/EZH2-inaktivierter CMML", "en": "MEK inhibition in RAS-mutated/EZH2-inactivated CMML" }, "short": null, "url": null, "abstract": { "de": "Forschungskontext/theoretischer Rahmen:\r\nDie chronische myelomonozytäre Leukämie (CMML) ist eine aggressive hämatopoetische Neoplasie, die häufig auf Aberrationen zurückzuführen ist, die die RAS-Onkogene verändern (RASmut). Leider sind die derzeitigen therapeutischen Ansätze für RASmut-CMML-Patienten unzureichend. Wir zeigen, dass RASmut bei CMML häufig mit inaktivierenden Aberrationen des epigenetischen Modifikators EZH2 (EZH2inact) einhergeht. In-vitro-Zellkulturstudien zeigen, dass myeloische Zellen mit RASmut/EZH2inact eine Hyperaktivierung der RAS-Signaltransduktion aufweisen und besonders stark auf eine RAS-MAPK/ERK-Inhibition mit MEK-Inhibitoren (MEKi) reagieren.\r\n\r\nHypothesen/Forschungsfragen/Zielsetzungen:\r\nForschungsfrage: \r\nWir fragen, ob unterschiedliche pharmakologische Ansätze therapeutisch auf RASmut/EZH2inact CMML abzielen können.\r\nHypothese: \r\nWir stellen die Hypothese auf, dass RASmut und EZH2inact synergistisch RAS-Signalwege in CMML aktivieren und eine erhöhte Empfindlichkeit gegenüber MEKi verleihen.\r\nZielsetzungen: \r\nDurch die strategische Einbindung unserer Biobank mit klinisch gut annotierten Patientenproben in modernste In-vitro- und In-vivo-Ansätze werden wir zunächst unser Wissen über die Auswirkungen des gemeinsamen Auftretens von RASmut/EZH2inact auf die RAS-MAPK/ERK-Signalübertragung bei CMML erweitern. Anschließend werden wir die MEKi-Therapie in diesen Modellen analysieren und nach einer bevorzugten Empfindlichkeit des RASmut/EZH2inact-Genotyps fragen. Schließlich werden wir die Auswirkungen von MEKi auf RASmut/EZH2inact CMML-Leukämie-Stammzellen (LSC) und die klonale Evolution untersuchen. \r\n\r\nHerangehensweise/Methoden:\r\nWir werden zunächst die Auswirkungen von EZH2inact auf die Aktivierung der RASmut-Signalübertragung in transgenen In-vivo-Mausmodellen, primären CMML-Patientenproben und von Patienten stammenden Xenografts (PDX) untersuchen. Diese Analysen werden die durchflusszytometrische Bewertung des RAS-signalisings in hämatopoetischen Stamm- und Vorläuferzellen (HSPC) und LSC umfassen. Anschließend werden wir diese Modelle verwenden, um die Auswirkungen des gleichzeitigen Auftretens von RASmut/EZH2inact auf MEKi zu bewerten. Letztendlich wollen wir das therapeutische Potenzial von MEKi zur Heilung von RASmut/EZH2inact CMML bewerten. Daher werden wir die Auswirkungen der MEKi-Behandlung auf RASmut/EZH2inact-HSPC-Kompartimente, CMML-LSC und die klonale Evolution der CMML untersuchen. \r\n\r\nGrad der Originalität/Innovation:\r\nDie gezielte Beeinflussung der aberranten RAS-Signalübertragung ist seit Jahrzehnten ein wichtiger Forschungsschwerpunkt. Obwohl seit kurzem direkte RAS-Inhibitoren der nächsten Generation zur Verfügung stehen, war der therapeutische Nutzen für RASmut-CMML-Patienten begrenzt. Dieses Projekt untersucht einen neuartigen Ansatz und schlägt vor, dass eine erfolgreiche molekular gesteuerte Behandlung bei RASmut CMML den Einfluss von koexistierenden und funktionell interagierenden Läsionen berücksichtigen muss.\r\n\r\nBeteiligte Hauptforscher:\r\nArmin Zebisch, der über eine langjährige Erfahrung auf dem Gebiet der RAS-Signalübertragung bei myeloischen Neoplasien verfügt, wird der Hauptforscher sein. Er wird von klinischen Hämatologen und Grundlagenforschern unterstützt, die über profunde Kenntnisse der CMML und der in diesem Projekt verwendeten Modelle verfügen. Ein Doktorand und ein Techniker werden sein Laborteam bei der Durchführung dieses Projekts unterstützen.\r\n", "en": "Wider research context/theoretical framework:\r\nChronic myelomonocytic leukemia (CMML) is an aggressive hematopoietic neoplasia and is frequently driven by aberrations modifying the RAS oncogenes (RASmut). Unfortunately, current therapeutic approaches for RASmut CMML patients are insufficient. We demonstrate that RASmut in CMML often co-occur with inactivating aberrations of the epigenetic modifier EZH2 (EZH2inact). In-vitro cell culture studies reveal that RASmut/EZH2inact myeloid cells exhibit RAS-signaling hyperactivation and might be preferentially sensitive to RAS-MAPK/ERK inhibition with MEK inhibitors (MEKi).\r\n\r\nHypotheses/research questions/objectives:\r\nResearch question: \r\nWe ask whether distinctive pharmacological approaches can therapeutically target RASmut/EZH2inact CMML.\r\nHypothesis:\r\nWe hypothesize that RASmut and EZH2inact synergistically activate RAS-signaling pathways in CMML and confer increased sensitivity to MEKi.\r\nObjectives: \r\nBy strategically incorporating our biobank with clinically well-annotated patient specimens into state-of-the-art in-vitro and in-vivo approaches, we will initially extend our knowledge on the effects of RASmut/EZH2inact co-occurrence on RAS-MAPK/ERK signaling in CMML. We will then analyze MEKi therapy within these models and ask for preferential sensitivity in the RASmut/EZH2inact genotype. Ultimately, we will assess the effects of MEKi on RASmut/EZH2inact CMML-leukemic stem cells (LSC) and clonal evolution. \r\n\r\nApproach/methods:\r\nWe will initially elaborate on the effects of EZH2inact on the activation of RASmut-signaling in transgenic murine in-vivo models, primary CMML patient specimens, and patient-derived xenografts (PDX). These analyses will include the flow-cytometry-based assessment of RAS-signaling in hematopoietic stem and progenitor cells (HSPC) and LSC. We will then use these models to assess the effects of RASmut/EZH2inact co-occurrence on MEKi. Ultimately, we will aim to assess the therapeutic potential of MEKi to cure RASmut/EZH2inact CMML. Therefore, we will study the effects of MEKi treatment on RASmut/EZH2inact HSPC compartments, CMML-LSC and clonal evolution of CMML. \r\nLevel of originality/innovation\r\nTargeting aberrant RAS signaling has been a significant focus of research for the last decades. Despite the recent advent of direct next-generation RAS inhibitors, the therapeutic benefit for RASmut CMML patients was limited. This project assesses a novel approach and proposes that successful molecular-guided treatment in RASmut CMML must consider the influence of co-existing and functionally interacting lesions.\r\nPrimary researchers involved\r\nArmin Zebisch has a strong track record on RAS-signaling in myeloid neoplasms and will be the principal investigator. He will be supported by clinical hematologists and basic researchers with profound expertise in CMML and the models used within this project. A PhD student and technician will further support his lab team in executing this project.\r\n" }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2028-01-01T01:00:00+01:00", "end_effective": "2029-12-31T01:00:00+01:00", "assignment": "2024-08-21T15:56:58+02:00", "program": 72, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 57402, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT 1753824", "ethics_committee": null, "edudract_number": null, "persons": [ "8362-57402-10", "8362-97430-12", "8362-97983-12", "8362-50116-12" ] }, { "id": 9568, "title": { "de": "OBELIX-NEPHROSE: B Zell Depletion in therapie-naiver MCD", "en": "OBELIX-NEPHROSIS: B CELLDEPLETION IN THERAPY-NAÏVE MCD" }, "short": "OBELIX-NEPHROSIS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-08-01T02:00:00+02:00", "end_planned": "2028-12-31T01:00:00+01:00", "end_effective": "2029-07-31T02:00:00+02:00", "assignment": "2026-01-29T13:31:32+01:00", "program": 111, "subprogram": null, "organization": 14084, "category": 10, "type": 10, "partner_function": 2, "manager": 94970, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9568-94970-10" ] }, { "id": 9014, "title": { "de": "Elemental and Structural Composition underlying Brain MRI", "en": "Elemental and Structural Composition underlying Brain MRI" }, "short": "WhatsMRI", "url": null, "abstract": { "de": "Magnetic Resonance Imaging (MRI) is widely established, with 50,000 scanners worldwide and more than100 million diagnostic scans conducted yearly. Myelin acts as the electrical insulation of neuronal fibers andis essential for motor, sensory, and cognitive functions and is composed of several lipids and proteins arrangedin a specific geometry. However, myelin loss occurs regionally in inflammatory diseases like multiplesclerosis, myelitis, and optic neuritis, and it also serves as a biomarker of aging.Despite the availability of various MRI-based approaches for detecting myelin, there remains a significant gapin systematically validated knowledge regarding how myelin's lipids, proteins, and structural variationsinfluence MRI signal generation. Furthermore, there is no gold standard for assessing the constituents ofmyelin, and conclusions are primarily based on MRI of formalin-fixed tissue.Quantitative post-mortem MRI of unfixed human brains in situ, combined with subsequent mass spectrometryimaging (LA-ICP-TOF-MS, MALDI-MSI), small-angle X-ray scattering (SAXS), and microscopy (CARS,TEM, IHC), will enable histologically enriched modelling of tissue and the simulation of fundamental MRIparameters (relaxometry, susceptibility, and diffusion) to reveal causal relationships with chemical elements,matrix composition, structure, and common molecules of myelin, neural fiber orientation, and biometals. Inaddition to 20 control brains, 10 brains from deceased individuals with multiple sclerosis will be recruited tobroaden the spectrum of myelination under investigation.This research addresses the fundamental biophysical mechanisms underlying MRI of myelin and chemicalelements, which currently lack validation. We will establish a publicly available elemental and histochemicalatlas of the human brain and identify how histological features causally contribute to quantitative MRIparameters.", "en": "Magnetic Resonance Imaging (MRI) is widely established, with 50,000 scanners worldwide and more than100 million diagnostic scans conducted yearly. Myelin acts as the electrical insulation of neuronal fibers andis essential for motor, sensory, and cognitive functions and is composed of several lipids and proteins arrangedin a specific geometry. However, myelin loss occurs regionally in inflammatory diseases like multiplesclerosis, myelitis, and optic neuritis, and it also serves as a biomarker of aging.Despite the availability of various MRI-based approaches for detecting myelin, there remains a significant gapin systematically validated knowledge regarding how myelin's lipids, proteins, and structural variationsinfluence MRI signal generation. Furthermore, there is no gold standard for assessing the constituents ofmyelin, and conclusions are primarily based on MRI of formalin-fixed tissue.Quantitative post-mortem MRI of unfixed human brains in situ, combined with subsequent mass spectrometryimaging (LA-ICP-TOF-MS, MALDI-MSI), small-angle X-ray scattering (SAXS), and microscopy (CARS,TEM, IHC), will enable histologically enriched modelling of tissue and the simulation of fundamental MRIparameters (relaxometry, susceptibility, and diffusion) to reveal causal relationships with chemical elements,matrix composition, structure, and common molecules of myelin, neural fiber orientation, and biometals. Inaddition to 20 control brains, 10 brains from deceased individuals with multiple sclerosis will be recruited tobroaden the spectrum of myelination under investigation.This research addresses the fundamental biophysical mechanisms underlying MRI of myelin and chemicalelements, which currently lack validation. We will establish a publicly available elemental and histochemicalatlas of the human brain and identify how histological features causally contribute to quantitative MRIparameters." }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2030-01-01T01:00:00+01:00", "end_effective": "2030-09-30T02:00:00+02:00", "assignment": "2025-06-10T15:39:19+02:00", "program": 208, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 3, "manager": 60116, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9014-70759-11", "9014-86408-11", "9014-101162-11", "9014-60116-10", "9014-132017-12", "9014-134821-12", "9014-135321-12", "9014-135543-12", "9014-127954-12" ] }, { "id": 8573, "title": { "de": "Integrierter Ansatz zur Gewebsheilung: Ein bioaktives magnetisches Pflaster mit Hyperthermie und immobilisiertem Humanserumalbumin", "en": "Integrative approach to tissue healing: A bioactive magnetic patch with hyperthermia and immobilized human serum albumin" }, "short": "BIMA-Patch", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-12-19T15:25:02+01:00", "program": 207, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 124253, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "BA 07/2025", "ethics_committee": null, "edudract_number": null, "persons": [ "8573-124253-10" ] } ] }