Project List
List projects.
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GET /v1/research/project/?format=api&offset=260&ordering=begin_planned
{ "count": 2244, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=280&ordering=begin_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=240&ordering=begin_planned", "results": [ { "id": 2254, "title": { "de": "Nanoelectronics for Mobile Ambient Assisted Living (AAL) Systems - Technology Platform for AAL Applications - MAS", "en": "Nanoelectronics for Mobile Ambient Assisted Living (AAL) Systems - Technology Platform for AAL Applications - MAS" }, "short": "MAS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2010-07-15T12:58:37+02:00", "program": 24, "subprogram": "ENIAC", "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": 51831, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10, 416 ], "funder_projectcode": "120228", "ethics_committee": null, "edudract_number": null, "persons": [ "2254-51831-10" ] }, { "id": 2327, "title": { "de": "Vollkeramische Sofortversorgung einteiliger Zirkonoxidimplantate", "en": "All ceramic immediate provisional restoration of Circonia single-peace implants" }, "short": "Vollkeramische Sofortversorgung", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2011-10-31T01:00:00+01:00", "assignment": "2010-10-13T13:26:05+02:00", "program": null, "subprogram": null, "organization": 14057, "category": 10, "type": 10, "partner_function": 1, "manager": 50792, "contact": 50792, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2327-50792-10" ] }, { "id": 2381, "title": { "de": "EUTRAF - THE EUROPEAN NETWORK FOR TRANSLATIONAL RESEARCH IN ATRIAL FIBRILLATION", "en": "EUTRAF - THE EUROPEAN NETWORK FOR TRANSLATIONAL RESEARCH IN ATRIAL FIBRILLATION" }, "short": "EUTRAF", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2015-12-31T01:00:00+01:00", "end_effective": "2015-10-31T01:00:00+01:00", "assignment": "2011-01-19T10:52:22+01:00", "program": 24, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 2, "manager": 50168, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "261057", "ethics_committee": null, "edudract_number": null, "persons": [ "2381-60041-12", "2381-66430-12", "2381-79173-12", "2381-50168-10" ] }, { "id": 2152, "title": { "de": "Variation des Erythropoetin-Gens als Risikofaktor für Brustkrebs", "en": "Variation des Erythropoetin-Gens als Risikofaktor für Brustkrebs" }, "short": "ERYTHROPOETIN_BRUSTKREBS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2010-12-31T01:00:00+01:00", "end_effective": "2011-06-30T02:00:00+02:00", "assignment": "2010-03-04T14:48:32+01:00", "program": 81, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 58814, "contact": 58814, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 52 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2152-58814-10" ] }, { "id": 2031, "title": { "de": "Genetic variants in the RAD51, BRCA1 and BRCA2 genes as predictors of radiation response and toxicity in prostate cancer patients", "en": "Genetic variants in the RAD51, BRCA1 and BRCA2 genes as predictors of radiation response and toxicity in prostate cancer patients" }, "short": "GENETIC_PROSTATE_CANCER_OeNB", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-01-11T15:12:11+01:00", "program": 79, "subprogram": null, "organization": 14060, "category": 10, "type": 10, "partner_function": 4, "manager": 50495, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2031-50495-10", "2031-50910-12" ] }, { "id": 2256, "title": { "de": "Stammbaumanalysen bei PatientInnen mit Therapie-assoziierten myeloischen Neoplasien", "en": "Stammbaumanalysen bei PatientInnen mit Therapie-assoziierten myeloischen Neoplasien" }, "short": "myeloische Neoplasien", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-06-30T02:00:00+02:00", "end_effective": "2014-04-30T02:00:00+02:00", "assignment": "2010-07-28T12:50:24+02:00", "program": null, "subprogram": "Land Steiermark Abteilung 3 (Forschung); Projektsumme über 5.000,- ", "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51857, "contact": 51857, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2256-77615-12", "2256-77770-12", "2256-51857-10", "2256-50116-12" ] }, { "id": 2183, "title": { "de": "Entwicklung von strukturierten Oberflächen für die optimierte Adhäsion, Proliferation und Differenzierung von Zellen", "en": "Entwicklung von strukturierten Oberflächen für die optimierte Adhäsion, Proliferation und Differenzierung von Zellen" }, "short": "ENTWICKLUNG STRUKTUR OBERFLÄCHEN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-03-01T01:00:00+01:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2014-02-28T01:00:00+01:00", "assignment": "2010-04-19T15:05:26+02:00", "program": null, "subprogram": null, "organization": 14050, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2183-63490-12", "2183-67749-12" ] }, { "id": 2043, "title": { "de": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action", "en": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action" }, "short": "ORPHAN RECEPTOR GPR55", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-01-20T12:45:29+01:00", "program": 92, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1903, "title": { "de": "Funktionelle Magentresonanztomographie zum Studium motorischer Rehabilitation nach Schlaganfall", "en": "Funktionelle Magentresonanztomographie zum Studium motorischer Rehabilitation nach Schlaganfall" }, "short": "Motorische Rehabilitation ", "url": null, "abstract": { "de": "Die funktionelle Limitation motorischer Defizite nach Schlafganfall steht im Zentrum der Bemühungen der Neurorehabilitation. Moderne neurorehabilitative Strategien zielen hierbei primär auf eine Förderung neuronaler Plastizität ab, wobei das individuelle Ansprechen auf therapeutische Bemühungen auf Basis klinischer Kriterien schwer vorhersagbar ist. Im vorliegenden Projekt soll die Methode der funktionellen Magnetresonanztomographie (fMRT) eingesetzt werden, um zu klären, inwieweit Unterschiede in mit motorischem Sequenzlernen assoziierten fMRT Aktivierungsänderungen Vorhersagewert im Hinblick auf die motorische Rehabilitationsfähigkeit von Schlaganfall-Betroffenen aufweisen. Von derartigen Einblicken lassen sich unter Umständen eine wesentliche Hilfestellung hinsichtlich der Selektion von PatientInnen oder auch die Entwicklung neuartiger Rehabilitationsstrategien erhoffen.", "en": "Die funktionelle Limitation motorischer Defizite nach Schlafganfall steht im Zentrum der Bemühungen der Neurorehabilitation. Moderne neurorehabilitative Strategien zielen hierbei primär auf eine Förderung neuronaler Plastizität ab, wobei das individuelle Ansprechen auf therapeutische Bemühungen auf Basis klinischer Kriterien schwer vorhersagbar ist. Im vorliegenden Projekt soll die Methode der funktionellen Magnetresonanztomographie (fMRT) eingesetzt werden, um zu klären, inwieweit Unterschiede in mit motorischem Sequenzlernen assoziierten fMRT Aktivierungsänderungen Vorhersagewert im Hinblick auf die motorische Rehabilitationsfähigkeit von Schlaganfall-Betroffenen aufweisen. Von derartigen Einblicken lassen sich unter Umständen eine wesentliche Hilfestellung hinsichtlich der Selektion von PatientInnen oder auch die Entwicklung neuartiger Rehabilitationsstrategien erhoffen." }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2013-07-01T02:00:00+02:00", "end_effective": "2013-07-01T02:00:00+02:00", "assignment": "2009-08-27T14:08:42+02:00", "program": 79, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 50173, "contact": 50173, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1903-70680-12", "1903-50173-10" ] }, { "id": 1798, "title": { "de": "DALI - Vitamin D and Lifestyle Intervention for GDM Prevention", "en": "DALI - Vitamin D and Lifestyle Intervention for GDM Prevention" }, "short": "DALI", "url": null, "abstract": { "de": "Europe is facing an unprecedented threat from Type 2 diabetes (T2D) with associated human suffering and economic burden and rapidly growing proportions. While T2D is traditionally associated with sedentary lifestyle and unhealthy diet, the currently observed growth in developed countries is greater than expected from lifestyle changes alone. Evidence is accumulating that GDM is a more important contributor to these epidemics than prevoiusly recognised.\r\n\r\nIn this study, we will use an exploratory trial approach to develop the best intervention for preventing gestational diabetes mellitus (GDM). We will concurrently use the trial data, samples and cohorts to increase our understanding of the pathophysiological mechanisms leading to enhanced diabetes and obesity risk to mother and baby. Building upon the expertise of members of the Diabetes in Pregnancy Study Group Europe (DPSG) and joined by behavioural researchers and health economists, our study is designed to collate the evidence around the epidemiology of GDM in Europe, to promote pan-European standards and measures for GDM and identify suitable preventive measures against GDM.", "en": "Europe is facing an unprecedented threat from Type 2 diabetes (T2D) with associated human suffering and economic burden and rapidly growing proportions. While T2D is traditionally associated with sedentary lifestyle and unhealthy diet, the currently observed growth in developed countries is greater than expected from lifestyle changes alone. Evidence is accumulating that GDM is a more important contributor to these epidemics than prevoiusly recognised.\r\n\r\nIn this study, we will use an exploratory trial approach to develop the best intervention for preventing gestational diabetes mellitus (GDM). We will concurrently use the trial data, samples and cohorts to increase our understanding of the pathophysiological mechanisms leading to enhanced diabetes and obesity risk to mother and baby. Building upon the expertise of members of the Diabetes in Pregnancy Study Group Europe (DPSG) and joined by behavioural researchers and health economists, our study is designed to collate the evidence around the epidemiology of GDM in Europe, to promote pan-European standards and measures for GDM and identify suitable preventive measures against GDM." }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-03-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2015-12-31T01:00:00+01:00", "assignment": "2009-04-27T16:25:57+02:00", "program": 24, "subprogram": "HEALTH-2009-2.4.3-1", "organization": 14038, "category": 10, "type": 10, "partner_function": 3, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2093, "title": { "de": "Isolation of Side Population Cells in Human Soft Tissue Sarcomas", "en": "Isolation of Side Population Cells in Human Soft Tissue Sarcomas" }, "short": "ISOLATION OF SIDE POP CELLS ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T12:52:51+01:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50696, "contact": 50696, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2093-50696-10" ] }, { "id": 2431, "title": { "de": "Genetic predisposition to therapy-related myeloid neoplasms: involvement of the Fanconi anemia/BRCA pathway?", "en": "Genetic predisposition to therapy-related myeloid neoplasms: involvement of the Fanconi anemia/BRCA pathway?" }, "short": "FANCONI ANEMIA BRCA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2011-02-28T11:28:49+01:00", "program": 79, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51857, "contact": 51857, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2431-77371-12", "2431-77615-12", "2431-51857-10", "2431-50116-12" ] }, { "id": 2092, "title": { "de": "Analysis of germline polymorphisms in the VEGF/VEGFR pathway to predict colorectal cancer outcome", "en": "Analysis of germline polymorphisms in the VEGF/VEGFR pathway to predict colorectal cancer outcome" }, "short": "GERMLINE POLYMORPH VEGF/VEGFR", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2010-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T11:47:57+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2092-58814-12" ] }, { "id": 2165, "title": { "de": "\"Blauer LASER\" in der Akupunktur-Weltweit erste wissenschaftliche Untersuchungen am interuniversitären TCM Forschungszentrum Graz", "en": "\"Blauer LASER\" in der Akupunktur-Weltweit erste wissenschaftliche Untersuchungen am interuniversitären TCM Forschungszentrum Graz" }, "short": "Blauer LASER", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2011-06-30T02:00:00+02:00", "end_effective": "2011-09-30T02:00:00+02:00", "assignment": "2010-03-29T18:06:01+02:00", "program": null, "subprogram": null, "organization": 14044, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2052, "title": { "de": "Etablierung und Evaluierung eines Bluttestes für die Detektion von Endothel - Lipase im Serum ¿ einem potentiellen Marker für Arteriosklerose", "en": "Etablierung und Evaluierung eines Bluttestes für die Detektion von Endothel - Lipase im Serum ¿ einem potentiellen Marker für Arteriosklerose" }, "short": "ENDOTHEL LIPASE IM SERUM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-03-25T01:00:00+01:00", "end_planned": "2010-06-30T02:00:00+02:00", "end_effective": "2010-12-24T01:00:00+01:00", "assignment": "2010-01-21T13:36:00+01:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2051, "title": { "de": "Bedeutung des Endothelinsystems bei der Pathogenese der Präeklamsie", "en": "Bedeutung des Endothelinsystems bei der Pathogenese der Präeklamsie" }, "short": "Endothelinsystems und Präeklamsie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2010-12-31T01:00:00+01:00", "end_effective": "2011-07-30T02:00:00+02:00", "assignment": "2010-01-21T12:47:04+01:00", "program": null, "subprogram": "Land Steiermark-Projekt über 5.000,- Euro Antragssumme", "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2155, "title": { "de": "Remote Assessibility to Diabetes Management and Therapy in Operational healthcare Networks - REACTION", "en": "Remote Assessibility to Diabetes Management and Therapy in Operational healthcare Networks - REACTION" }, "short": "REACTION", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-03-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2014-02-28T01:00:00+01:00", "assignment": "2010-03-05T10:04:48+01:00", "program": 24, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "248590", "ethics_committee": null, "edudract_number": null, "persons": [ "2155-51831-10", "2155-59231-12", "2155-64875-12", "2155-65558-12" ] }, { "id": 2076, "title": { "de": "Identifikation von neuen Biomarkern und ß-Zellantigenen bei PatientInnen mit Typ 1 Diabetes und deren Verwandten ersten Grades: Stufe 1 des Österreichischen Diabetes Präventions-Programmes (ADPP-001)", "en": "Identification of new biomarkers an ß cell antigens in type 1 diabetic subjects and their first-degree relatives: Step 1 of the Austrian Diabetes Prevention Programme (ADPP-001)" }, "short": "ADPP-001", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2010-02-04T16:37:59+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 51831, "contact": 51831, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 984 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2076-51831-10", "2076-50551-12", "2076-67348-12", "2076-76349-12" ] }, { "id": 2097, "title": { "de": "Role of SPN in PP1-mediated RyR2 regulation and intracellular Ca2+ handling", "en": "Role of SPN in PP1-mediated RyR2 regulation and intracellular Ca2+ handling" }, "short": "ROLE OF SPN ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T12:56:38+01:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2090, "title": { "de": "Expression profiling in hypoxic non-small cell lung cancer", "en": "Expression profiling in hypoxic non-small cell lung cancer" }, "short": "NON-SMALL CELL LUNG CANCER ", "url": null, "abstract": { "de": "Das Bronchialkarzinom ist nach wie vor die führende Krebstodesursache weltweit. 80% sind sogenannte Nicht-kleinzellige Bronchialkarzinome (non-small cell lung cancers, NSCLC). Das Gesamtüberleben der Patienten mit NSCLC ist schlecht, trotz der derzeit vorhandenen Therapieoptionen, zum Teil wegen Resistenz gegenüber Radio- und Chemotherapie. Tumorhypoxie (verminderte Sauerstoffzufuhr im Tumor) induziert in den Tumorzellen Adaptationsvorgänge und ist zum Teil für die Therapieresistenz verantwortlich. Die genauen Mechanismen sind jedoch nicht bekannt. Unser neu etabliertes ex-vivo Modell der hypoxischen Adaptation beim NSCLC, welches auf der Verwendung von kleinsten NSCLC Fragmenten aus Operationsmaterial beruht, ist geignet, um die Vorgänge im Tumor unter hypoxischen Bedingungen zu untersuchen. Das Ziel der vorliegenden Studie ist, die Genexpressionsmuster der in Hypoxie bzw unter normalen Sauerstoffbedingungen kultivierten NSCLC Fragmente zu vergleichen. Die differenziell regulierten Gene werden dafür mittels cDNA microarrays bestimmt. Die Ergebnisse werden in nachfolgenden Einzelgen-Polymerase Kettenreaktionen validiert. Unsere Studie könnte somit das Verständnis der Pathomechanismen beim Tumorwachstum verbessern und mögliche neue Therapieoptionen beim NSCLC aufzeigen.", "en": "Lung cancer is the leading cause of cancer deaths overall in the world. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancers. Overall survival is poor, in part due to resistance to chemotherapy and radiotherapy. Intratumoral hypoxia (limited oxygen supply) frequently occurs in solid tumors, such as NSCLC. Hypoxia initiates adaptive responses in tumor cells and was shown to induce chemotherapy resistance and promote aggressive tumor growth. The mechanisms of hypoxia-induced adaptive responses in solid tumors are not fully elucidated, yet. We established an ex-vivo model for hypoxic adaptation using NSCLC surgery fragments. The fragments are maintained in short-time culture in hypoxia or ambient oxygen (normoxia) without significant loss of viability or increase in apoptosis and display significant induction of carbonic anhydrase IX, a marker for tumor hypoxia, under hypoxic conditions. The aim of the current study is to analyze hypoxia-induced gene expression changes using cDNA microarrays and consecutive single gene real-time polymerase chain reaction (RT-PCR) on hypoxic vs. normoxic NSCLC fragments, in order to identify genes that are consistently induced or suppressed in hypoxia. Our study thus provides a novel approach to identify molecular pathways that are crucial for hypoxic adaptive changes in NSCLC and might represent targets for therapy." }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T11:39:13+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 57557, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2090-57557-10" ] } ] }