Project List
List projects.
Fields
id (integer)
Primary key.
Expansions
To activate relation expansion add the desired fields as a comma separated
list to the expand query parameter like this:
?expand=<field>,<field>,<field>,...
The following relational fields can be expanded:
organizationcategorytypepartner_functionmanagercontactstatusgrantresearcheventstudylanguageprogramfunders
Filters
To filter for exact value matches:
?<fieldname>=<value>
Possible exact filters:
organizationcategorymanagercontactstatusgrantresearchstudylanguagefundersprogram
For advanced filtering use lookups:
?<fieldname>__<lookup>=<value>
All fields with advanced lookups can also be used for exact value matches as described above.
Possible advanced lookups:
begin_planned:gt,gte,lt,ltebegin_effective:gt,gte,lt,lteend_planned:gt,gte,lt,lteend_effective:gt,gte,lt,lte
GET /v1/research/project/?format=api&offset=240&ordering=begin_planned
{ "count": 2244, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=260&ordering=begin_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=220&ordering=begin_planned", "results": [ { "id": 2162, "title": { "de": "Xerostomie und orale Mukositis bei PatientInnen mit Plattenepithelkarzinomen im Hals/Kopf Bereich unter Strahlentherapie: Biomarker aus dem Speichel und die mikrobiologische Kolonisierug der Mundhöhle", "en": "Xerostomia and oral mucositis in patients with squamous cell cancer of the head and neck undergoing radiotherapy: Salivary biomarkers and oral microbiological colonization" }, "short": "XEROSANT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-10-01T02:00:00+02:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2011-03-31T02:00:00+02:00", "end_effective": "2011-08-31T02:00:00+02:00", "assignment": "2010-03-15T14:29:34+01:00", "program": null, "subprogram": "1 x ige Anschubfinanzierung - Stipendium der Österreichischen Gesellschaft für Laboratoriumsmedizin und Klinische Chemie", "organization": 14028, "category": 10, "type": 10, "partner_function": 4, "manager": 50564, "contact": 50564, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 990 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2162-50564-10", "2162-62261-12", "2162-51803-12", "2162-51812-12", "2162-51976-11" ] }, { "id": 2198, "title": { "de": "Kommunikation als Screeninginstrument", "en": "Kommunikation als Screeninginstrument" }, "short": "KOMMUNIK_SCREENING", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-10-01T02:00:00+02:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2011-05-31T02:00:00+02:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2010-05-07T16:16:27+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": 54332, "contact": 54332, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 70 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2198-54332-10" ] }, { "id": 1868, "title": { "de": "Computer-based analysis of heart rate variability (HRV) during different methods of acupuncture", "en": "Computer-based analysis of heart rate variability (HRV) during different methods of acupuncture" }, "short": "HRV during acupuncture", "url": null, "abstract": { "de": "Die Herzratenvariabilität stellt die prozentuelle Änderung aufeinander folgender Kammerkomplexe im EKG dar. Der Parameter HRV wird durch das Blutdruckkontrollsystem, Einflüsse vom Hypothalamus und vor allem durch den vagalen Teil des Kreislaufzentrums im unteren Hirnstamm vermittelt. Eine computergestützte Analyse der HRV soll während unterschiedlicher Methoden der Akupunktur und anderer Stimulationsmethoden im gegenständlichen Projekt zum Einsatz kommen. Für die Untersuchungen soll ein Medilog AR 12 verwendet werden. Insgesamt sollen 80 Probanden (im Alter 20-50 Jahren) während unterschiedlicher Akupunktursitzungen (Nadel- und Laserakupunktur) untersucht werden. Dabei werden die folgenden Akupunkturpunkte verwendet: Neiguan (Pe.6), Shenmen (He.7) und Hegu (Di.4). Innerhalb dieses Projektes soll die HRV auch während Stimulationen des Punktes Yintang (Ex.1) näher untersucht werden. Das Projekt könnte dazu beitragen, die Beziehungen zwischen westlicher und östlicher Medizin zu vertiefen.", "en": "Die Herzratenvariabilität stellt die prozentuelle Änderung aufeinander folgender Kammerkomplexe im EKG dar. Der Parameter HRV wird durch das Blutdruckkontrollsystem, Einflüsse vom Hypothalamus und vor allem durch den vagalen Teil des Kreislaufzentrums im unteren Hirnstamm vermittelt. Eine computergestützte Analyse der HRV soll während unterschiedlicher Methoden der Akupunktur und anderer Stimulationsmethoden im gegenständlichen Projekt zum Einsatz kommen. Für die Untersuchungen soll ein Medilog AR 12 verwendet werden. Insgesamt sollen 80 Probanden (im Alter 20-50 Jahren) während unterschiedlicher Akupunktursitzungen (Nadel- und Laserakupunktur) untersucht werden. Dabei werden die folgenden Akupunkturpunkte verwendet: Neiguan (Pe.6), Shenmen (He.7) und Hegu (Di.4). Innerhalb dieses Projektes soll die HRV auch während Stimulationen des Punktes Yintang (Ex.1) näher untersucht werden. Das Projekt könnte dazu beitragen, die Beziehungen zwischen westlicher und östlicher Medizin zu vertiefen." }, "begin_planned": "2009-10-01T02:00:00+02:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-09-30T02:00:00+02:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2009-07-13T18:54:46+02:00", "program": 79, "subprogram": null, "organization": 14044, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1868-54121-12" ] }, { "id": 2074, "title": { "de": "Gamma Knife Radiochirurgie zur Behandlung des malignen Melanoms der Aderhaut - eine multizentrische randomisierte prospektive Studie", "en": "Gamma Knife Radiochirurgie zur Behandlung des malignen Melanoms der Aderhaut - eine multizentrische randomisierte prospektive " }, "short": "Gamma Knife Radiochirurgie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-10-01T02:00:00+02:00", "begin_effective": "2009-10-01T02:00:00+02:00", "end_planned": "2011-09-30T02:00:00+02:00", "end_effective": "2011-09-30T02:00:00+02:00", "assignment": "2010-02-02T16:33:12+01:00", "program": null, "subprogram": "Land Steiermark Projekt über5.000,- Euro", "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1944, "title": { "de": "The role of HOXB4 in renal development, maldevelopment of the kidney and tumorigeneses of renal neoplasms", "en": "The role of HOXB4 in renal development, maldevelopment of the kidney and tumorigeneses of renal neoplasms" }, "short": "ROLE OF HOXB4", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-11-01T01:00:00+01:00", "begin_effective": "2009-11-01T01:00:00+01:00", "end_planned": "2010-10-31T02:00:00+02:00", "end_effective": "2010-10-31T02:00:00+02:00", "assignment": "2009-10-07T13:44:40+02:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 52569, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1944-52569-10" ] }, { "id": 2030, "title": { "de": "Inotrope Effekte der milden Hypothermie", "en": "Inotrope Effekte der milden Hypothermie" }, "short": "MILDE HYOPTHERMIE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-11-01T01:00:00+01:00", "begin_effective": "2009-11-01T01:00:00+01:00", "end_planned": "2010-06-30T02:00:00+02:00", "end_effective": "2010-06-30T02:00:00+02:00", "assignment": "2010-01-11T13:54:54+01:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2040, "title": { "de": "Wirkung chirurgischer und pharmakologischer Interventionen auf das fetale Lungenwachstum bei pulmonaler Hypoplasie", "en": "Impact of surgical and pharmacological interventions on fetal lung growth in pulmonary hypoplasia" }, "short": "IncreaseLungGrowth08", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-12-15T01:00:00+01:00", "begin_effective": "2009-12-15T01:00:00+01:00", "end_planned": "2012-12-15T01:00:00+01:00", "end_effective": "2012-12-15T01:00:00+01:00", "assignment": "2010-01-18T12:45:19+01:00", "program": 24, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 50155, "contact": 50155, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2040-50155-10" ] }, { "id": 2023, "title": { "de": "Induction of immunological changes by endoluminal photodynamic therapy (PDT) for esophageal carcinoma", "en": "Induction of immunological changes by endoluminal photodynamic therapy (PDT) for esophageal carcinoma" }, "short": "PDT_ESOPHAGEAL_CARCINOMA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2009-12-18T12:29:42+01:00", "program": 79, "subprogram": null, "organization": 14077, "category": 10, "type": 10, "partner_function": 4, "manager": 51615, "contact": 51615, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2023-62056-12", "2023-51615-10", "2023-51618-12" ] }, { "id": 1798, "title": { "de": "DALI - Vitamin D and Lifestyle Intervention for GDM Prevention", "en": "DALI - Vitamin D and Lifestyle Intervention for GDM Prevention" }, "short": "DALI", "url": null, "abstract": { "de": "Europe is facing an unprecedented threat from Type 2 diabetes (T2D) with associated human suffering and economic burden and rapidly growing proportions. While T2D is traditionally associated with sedentary lifestyle and unhealthy diet, the currently observed growth in developed countries is greater than expected from lifestyle changes alone. Evidence is accumulating that GDM is a more important contributor to these epidemics than prevoiusly recognised.\r\n\r\nIn this study, we will use an exploratory trial approach to develop the best intervention for preventing gestational diabetes mellitus (GDM). We will concurrently use the trial data, samples and cohorts to increase our understanding of the pathophysiological mechanisms leading to enhanced diabetes and obesity risk to mother and baby. Building upon the expertise of members of the Diabetes in Pregnancy Study Group Europe (DPSG) and joined by behavioural researchers and health economists, our study is designed to collate the evidence around the epidemiology of GDM in Europe, to promote pan-European standards and measures for GDM and identify suitable preventive measures against GDM.", "en": "Europe is facing an unprecedented threat from Type 2 diabetes (T2D) with associated human suffering and economic burden and rapidly growing proportions. While T2D is traditionally associated with sedentary lifestyle and unhealthy diet, the currently observed growth in developed countries is greater than expected from lifestyle changes alone. Evidence is accumulating that GDM is a more important contributor to these epidemics than prevoiusly recognised.\r\n\r\nIn this study, we will use an exploratory trial approach to develop the best intervention for preventing gestational diabetes mellitus (GDM). We will concurrently use the trial data, samples and cohorts to increase our understanding of the pathophysiological mechanisms leading to enhanced diabetes and obesity risk to mother and baby. Building upon the expertise of members of the Diabetes in Pregnancy Study Group Europe (DPSG) and joined by behavioural researchers and health economists, our study is designed to collate the evidence around the epidemiology of GDM in Europe, to promote pan-European standards and measures for GDM and identify suitable preventive measures against GDM." }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-03-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2015-12-31T01:00:00+01:00", "assignment": "2009-04-27T16:25:57+02:00", "program": 24, "subprogram": "HEALTH-2009-2.4.3-1", "organization": 14038, "category": 10, "type": 10, "partner_function": 3, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2183, "title": { "de": "Entwicklung von strukturierten Oberflächen für die optimierte Adhäsion, Proliferation und Differenzierung von Zellen", "en": "Entwicklung von strukturierten Oberflächen für die optimierte Adhäsion, Proliferation und Differenzierung von Zellen" }, "short": "ENTWICKLUNG STRUKTUR OBERFLÄCHEN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-03-01T01:00:00+01:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2014-02-28T01:00:00+01:00", "assignment": "2010-04-19T15:05:26+02:00", "program": null, "subprogram": null, "organization": 14050, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2183-63490-12", "2183-67749-12" ] }, { "id": 2043, "title": { "de": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action", "en": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action" }, "short": "ORPHAN RECEPTOR GPR55", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-01-20T12:45:29+01:00", "program": 92, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2256, "title": { "de": "Stammbaumanalysen bei PatientInnen mit Therapie-assoziierten myeloischen Neoplasien", "en": "Stammbaumanalysen bei PatientInnen mit Therapie-assoziierten myeloischen Neoplasien" }, "short": "myeloische Neoplasien", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-06-30T02:00:00+02:00", "end_effective": "2014-04-30T02:00:00+02:00", "assignment": "2010-07-28T12:50:24+02:00", "program": null, "subprogram": "Land Steiermark Abteilung 3 (Forschung); Projektsumme über 5.000,- ", "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51857, "contact": 51857, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2256-77615-12", "2256-77770-12", "2256-51857-10", "2256-50116-12" ] }, { "id": 1991, "title": { "de": "Proteomic characterization of mitochondrial ion channels", "en": "Proteomic characterization of mitochondrial ion channels" }, "short": "mitochondrial ion channels", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2012-03-13T01:00:00+01:00", "end_effective": "2012-03-13T01:00:00+01:00", "assignment": "2009-11-25T16:00:48+01:00", "program": 69, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "J2968-B19", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2119, "title": { "de": "Alzheimer drugs incorporated in nanoparticles for specific transport over the blood brain barrier (NanoBrain)", "en": "Alzheimer drugs incorporated in nanoparticles for specific transport over the blood brain barrier (NanoBrain)" }, "short": "NanoBrain", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-10-01T02:00:00+02:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2010-02-12T14:34:51+01:00", "program": 64, "subprogram": "ERA-Net", "organization": 14051, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I453", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2220, "title": { "de": "Stratifizierung genetischer Veränderungen von malignen Kindertumoren - Grundlage für eine personalisierte Therapie", "en": "Stratifizierung genetischer Veränderungen von malignen Kindertumoren - Grundlage für eine personalisierte Therapie" }, "short": "MALIGNE KINDERTUMORE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-07-01T02:00:00+02:00", "end_planned": "2010-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2010-06-09T10:58:03+02:00", "program": null, "subprogram": "MAE: IANr. eingetragen (01.06.2010)", "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 52569, "contact": 52569, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2220-52569-10" ] }, { "id": 2103, "title": { "de": "Fatty liver: Inhibition of Progression (Role of hepatic triglyceride lipases in the progression of NASH)", "en": "Fatty liver: Inhibition of Progression (Role of hepatic triglyceride lipases in the progression of NASH)" }, "short": "FLIP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2010-02-10T16:24:47+01:00", "program": 24, "subprogram": "HEALTH-2009-2.4.5-1", "organization": 14081, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "241762", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2093, "title": { "de": "Isolation of Side Population Cells in Human Soft Tissue Sarcomas", "en": "Isolation of Side Population Cells in Human Soft Tissue Sarcomas" }, "short": "ISOLATION OF SIDE POP CELLS ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T12:52:51+01:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50696, "contact": 50696, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2093-50696-10" ] }, { "id": 2095, "title": { "de": "Purkinje Topology", "en": "Purkinje Topology" }, "short": "PURKINJE TOPOLOGY", "url": null, "abstract": { "de": "Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. ", "en": "Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. " }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T12:53:47+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 50967, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2095-50967-10" ] }, { "id": 2375, "title": { "de": "Grazer Laser Studie GLAS", "en": "Grazer Laser Study GLAS" }, "short": "GLAS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-04-30T02:00:00+02:00", "end_effective": "2011-07-31T02:00:00+02:00", "assignment": "2011-01-10T11:10:16+01:00", "program": 75, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2051, "title": { "de": "Bedeutung des Endothelinsystems bei der Pathogenese der Präeklamsie", "en": "Bedeutung des Endothelinsystems bei der Pathogenese der Präeklamsie" }, "short": "Endothelinsystems und Präeklamsie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2010-12-31T01:00:00+01:00", "end_effective": "2011-07-30T02:00:00+02:00", "assignment": "2010-01-21T12:47:04+01:00", "program": null, "subprogram": "Land Steiermark-Projekt über 5.000,- Euro Antragssumme", "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] } ] }