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GET /v1/research/project/?format=api&offset=240&ordering=-end_planned
{ "count": 2244, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=260&ordering=-end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=220&ordering=-end_planned", "results": [ { "id": 9556, "title": { "de": "Österreichisch-afrikanische Forschungskooperation zur Untersuchung des toxikologischen und immunpharmakologischen Potenzials von kenianischem Khat (Catha edulis) zur Verbesserung nachhaltiger Lebensgrundlagen in Kenia\r\n", "en": "Austria-Africa Research Collaboration on Exploring the Toxicological and Immunopharmacological Potential of Kenyan Khat (Catha edulis) for Enhancing Quality Livelihoods in Kenya" }, "short": "Österr-afrikan Koop_kenianisches Khat", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-03-01T01:00:00+01:00", "begin_effective": "2026-03-01T01:00:00+01:00", "end_planned": "2028-02-28T01:00:00+01:00", "end_effective": "2028-02-29T01:00:00+01:00", "assignment": "2026-01-26T11:52:19+01:00", "program": 254, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 1, "manager": 60706, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9556-60706-10" ] }, { "id": 9148, "title": { "de": "Biosynthetisiertes Porphyrin-beladenes Hydrogel für die photodynamische Therapie von multiresistenter Candida albicans bei HIV-infizierten Patienten", "en": "Biosynthesised porphyrin loaded hydrogel for photodynamic\r\ntherapy of multidurg-resistant Candida albicans in HIV infected\r\npatients" }, "short": "BioPor-PDT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-03-01T01:00:00+01:00", "begin_effective": "2025-12-01T01:00:00+01:00", "end_planned": "2028-02-28T01:00:00+01:00", "end_effective": "2027-11-30T01:00:00+01:00", "assignment": "2025-08-14T16:24:27+02:00", "program": 254, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 124253, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "P161", "ethics_committee": null, "edudract_number": null, "persons": [ "9148-124253-10" ] }, { "id": 9226, "title": { "de": "Data Stewards für interoperables Management klinischer Daten innerhalb der Mission Cancer an der Med Uni Graz", "en": "Data stewards for interoperable clinical data management within the Cancer Mission at the Medical University of Graz" }, "short": "DS Mission Cancer", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-02-02T01:00:00+01:00", "begin_effective": "2026-02-02T01:00:00+01:00", "end_planned": "2028-02-01T01:00:00+01:00", "end_effective": "2028-02-01T01:00:00+01:00", "assignment": "2025-09-26T11:17:21+02:00", "program": 255, "subprogram": null, "organization": 28083, "category": 10, "type": 10, "partner_function": 4, "manager": 57544, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "FO999929811", "ethics_committee": null, "edudract_number": null, "persons": [ "9226-57544-10" ] }, { "id": 7304, "title": { "de": "Steirische Kinderkrebsforschung - Forschungseinheit für Krebserkrankungen und Störungen des Blutes und Immunsystems bei Kindern \r\n", "en": "Styrian Children's Cancer Research - Research Unit for Childhood Cancer and Inborn Errors of the Blood or Immunity" }, "short": "Steirische Kinderkrebsforschung", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-02-01T01:00:00+01:00", "begin_effective": "2023-01-01T01:00:00+01:00", "end_planned": "2028-01-31T01:00:00+01:00", "end_effective": "2027-12-31T01:00:00+01:00", "assignment": "2022-12-15T14:14:16+01:00", "program": null, "subprogram": null, "organization": 14092, "category": 10, "type": 10, "partner_function": 4, "manager": 85188, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1550 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7304-85188-10" ] }, { "id": 8609, "title": { "de": "Exogene eletrische und mechanische Stimulation durch eletronische Haut stimuliert die Zellprofileration der oralen Mundschleimhaut", "en": "Exogenous electrical and mechanical motion stimulation by using an electronic skin for support oral cell proliferation." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-02-01T01:00:00+01:00", "begin_effective": "2025-06-01T02:00:00+02:00", "end_planned": "2028-01-31T01:00:00+01:00", "end_effective": "2028-05-31T02:00:00+02:00", "assignment": "2025-01-21T17:58:12+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 133140, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "ESP6372324", "ethics_committee": null, "edudract_number": null, "persons": [ "8609-133140-10" ] }, { "id": 8578, "title": { "de": "OptimaMind - Verbesserung der kognitiven Funktion durch Ernährung", "en": "OptimaMind - Enhancing cognitive longevity through lifestyle and nutrition" }, "short": "OptimaMind", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-02-03T01:00:00+01:00", "begin_effective": "2025-02-03T01:00:00+01:00", "end_planned": "2028-01-31T01:00:00+01:00", "end_effective": "2028-01-31T01:00:00+01:00", "assignment": "2025-01-03T17:54:51+01:00", "program": 112, "subprogram": null, "organization": 28392, "category": 10, "type": 10, "partner_function": 2, "manager": 89175, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PIN8074224", "ethics_committee": null, "edudract_number": null, "persons": [ "8578-89175-10" ] }, { "id": 8589, "title": { "de": "Rejuvenated yeasts for better biorefineries", "en": "Rejuvenated yeasts for better biorefineries" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-31T01:00:00+01:00", "begin_effective": "2025-01-31T01:00:00+01:00", "end_planned": "2028-01-30T01:00:00+01:00", "end_effective": "2028-01-30T01:00:00+01:00", "assignment": "2025-01-10T10:29:19+01:00", "program": 94, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 113130, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8589-113130-10", "8589-132237-12" ] }, { "id": 8362, "title": { "de": "MEK Inhibition bei RAS-mutierter/EZH2-inaktivierter CMML", "en": "MEK inhibition in RAS-mutated/EZH2-inactivated CMML" }, "short": null, "url": null, "abstract": { "de": "Forschungskontext/theoretischer Rahmen:\r\nDie chronische myelomonozytäre Leukämie (CMML) ist eine aggressive hämatopoetische Neoplasie, die häufig auf Aberrationen zurückzuführen ist, die die RAS-Onkogene verändern (RASmut). Leider sind die derzeitigen therapeutischen Ansätze für RASmut-CMML-Patienten unzureichend. Wir zeigen, dass RASmut bei CMML häufig mit inaktivierenden Aberrationen des epigenetischen Modifikators EZH2 (EZH2inact) einhergeht. In-vitro-Zellkulturstudien zeigen, dass myeloische Zellen mit RASmut/EZH2inact eine Hyperaktivierung der RAS-Signaltransduktion aufweisen und besonders stark auf eine RAS-MAPK/ERK-Inhibition mit MEK-Inhibitoren (MEKi) reagieren.\r\n\r\nHypothesen/Forschungsfragen/Zielsetzungen:\r\nForschungsfrage: \r\nWir fragen, ob unterschiedliche pharmakologische Ansätze therapeutisch auf RASmut/EZH2inact CMML abzielen können.\r\nHypothese: \r\nWir stellen die Hypothese auf, dass RASmut und EZH2inact synergistisch RAS-Signalwege in CMML aktivieren und eine erhöhte Empfindlichkeit gegenüber MEKi verleihen.\r\nZielsetzungen: \r\nDurch die strategische Einbindung unserer Biobank mit klinisch gut annotierten Patientenproben in modernste In-vitro- und In-vivo-Ansätze werden wir zunächst unser Wissen über die Auswirkungen des gemeinsamen Auftretens von RASmut/EZH2inact auf die RAS-MAPK/ERK-Signalübertragung bei CMML erweitern. Anschließend werden wir die MEKi-Therapie in diesen Modellen analysieren und nach einer bevorzugten Empfindlichkeit des RASmut/EZH2inact-Genotyps fragen. Schließlich werden wir die Auswirkungen von MEKi auf RASmut/EZH2inact CMML-Leukämie-Stammzellen (LSC) und die klonale Evolution untersuchen. \r\n\r\nHerangehensweise/Methoden:\r\nWir werden zunächst die Auswirkungen von EZH2inact auf die Aktivierung der RASmut-Signalübertragung in transgenen In-vivo-Mausmodellen, primären CMML-Patientenproben und von Patienten stammenden Xenografts (PDX) untersuchen. Diese Analysen werden die durchflusszytometrische Bewertung des RAS-signalisings in hämatopoetischen Stamm- und Vorläuferzellen (HSPC) und LSC umfassen. Anschließend werden wir diese Modelle verwenden, um die Auswirkungen des gleichzeitigen Auftretens von RASmut/EZH2inact auf MEKi zu bewerten. Letztendlich wollen wir das therapeutische Potenzial von MEKi zur Heilung von RASmut/EZH2inact CMML bewerten. Daher werden wir die Auswirkungen der MEKi-Behandlung auf RASmut/EZH2inact-HSPC-Kompartimente, CMML-LSC und die klonale Evolution der CMML untersuchen. \r\n\r\nGrad der Originalität/Innovation:\r\nDie gezielte Beeinflussung der aberranten RAS-Signalübertragung ist seit Jahrzehnten ein wichtiger Forschungsschwerpunkt. Obwohl seit kurzem direkte RAS-Inhibitoren der nächsten Generation zur Verfügung stehen, war der therapeutische Nutzen für RASmut-CMML-Patienten begrenzt. Dieses Projekt untersucht einen neuartigen Ansatz und schlägt vor, dass eine erfolgreiche molekular gesteuerte Behandlung bei RASmut CMML den Einfluss von koexistierenden und funktionell interagierenden Läsionen berücksichtigen muss.\r\n\r\nBeteiligte Hauptforscher:\r\nArmin Zebisch, der über eine langjährige Erfahrung auf dem Gebiet der RAS-Signalübertragung bei myeloischen Neoplasien verfügt, wird der Hauptforscher sein. Er wird von klinischen Hämatologen und Grundlagenforschern unterstützt, die über profunde Kenntnisse der CMML und der in diesem Projekt verwendeten Modelle verfügen. Ein Doktorand und ein Techniker werden sein Laborteam bei der Durchführung dieses Projekts unterstützen.\r\n", "en": "Wider research context/theoretical framework:\r\nChronic myelomonocytic leukemia (CMML) is an aggressive hematopoietic neoplasia and is frequently driven by aberrations modifying the RAS oncogenes (RASmut). Unfortunately, current therapeutic approaches for RASmut CMML patients are insufficient. We demonstrate that RASmut in CMML often co-occur with inactivating aberrations of the epigenetic modifier EZH2 (EZH2inact). In-vitro cell culture studies reveal that RASmut/EZH2inact myeloid cells exhibit RAS-signaling hyperactivation and might be preferentially sensitive to RAS-MAPK/ERK inhibition with MEK inhibitors (MEKi).\r\n\r\nHypotheses/research questions/objectives:\r\nResearch question: \r\nWe ask whether distinctive pharmacological approaches can therapeutically target RASmut/EZH2inact CMML.\r\nHypothesis:\r\nWe hypothesize that RASmut and EZH2inact synergistically activate RAS-signaling pathways in CMML and confer increased sensitivity to MEKi.\r\nObjectives: \r\nBy strategically incorporating our biobank with clinically well-annotated patient specimens into state-of-the-art in-vitro and in-vivo approaches, we will initially extend our knowledge on the effects of RASmut/EZH2inact co-occurrence on RAS-MAPK/ERK signaling in CMML. We will then analyze MEKi therapy within these models and ask for preferential sensitivity in the RASmut/EZH2inact genotype. Ultimately, we will assess the effects of MEKi on RASmut/EZH2inact CMML-leukemic stem cells (LSC) and clonal evolution. \r\n\r\nApproach/methods:\r\nWe will initially elaborate on the effects of EZH2inact on the activation of RASmut-signaling in transgenic murine in-vivo models, primary CMML patient specimens, and patient-derived xenografts (PDX). These analyses will include the flow-cytometry-based assessment of RAS-signaling in hematopoietic stem and progenitor cells (HSPC) and LSC. We will then use these models to assess the effects of RASmut/EZH2inact co-occurrence on MEKi. Ultimately, we will aim to assess the therapeutic potential of MEKi to cure RASmut/EZH2inact CMML. Therefore, we will study the effects of MEKi treatment on RASmut/EZH2inact HSPC compartments, CMML-LSC and clonal evolution of CMML. \r\nLevel of originality/innovation\r\nTargeting aberrant RAS signaling has been a significant focus of research for the last decades. Despite the recent advent of direct next-generation RAS inhibitors, the therapeutic benefit for RASmut CMML patients was limited. This project assesses a novel approach and proposes that successful molecular-guided treatment in RASmut CMML must consider the influence of co-existing and functionally interacting lesions.\r\nPrimary researchers involved\r\nArmin Zebisch has a strong track record on RAS-signaling in myeloid neoplasms and will be the principal investigator. He will be supported by clinical hematologists and basic researchers with profound expertise in CMML and the models used within this project. A PhD student and technician will further support his lab team in executing this project.\r\n" }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2028-01-01T01:00:00+01:00", "end_effective": "2029-12-31T01:00:00+01:00", "assignment": "2024-08-21T15:56:58+02:00", "program": 72, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 57402, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT 1753824", "ethics_committee": null, "edudract_number": null, "persons": [ "8362-57402-10", "8362-97430-12", "8362-97983-12", "8362-50116-12" ] }, { "id": 8189, "title": { "de": "Orphan Device für pädiatrische Patienten: eine einzigartige Plattform mit innovativen Dienstleistungen", "en": "Orphan Device for paediatric patients: a unique platform providing innovative services" }, "short": "OrphaDev4kids", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2028-01-01T01:00:00+01:00", "end_effective": "2027-06-30T02:00:00+02:00", "assignment": "2024-05-08T10:42:03+02:00", "program": null, "subprogram": "EU4H-2023-PJ", "organization": 14052, "category": 10, "type": 10, "partner_function": 2, "manager": 50785, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101161377", "ethics_committee": null, "edudract_number": null, "persons": [ "8189-50785-10" ] }, { "id": 8142, "title": { "de": "TARgetinG disease pErsisTence and progression of\r\nMyeloProliferative Neoplasms", "en": "TARgetinG disease pErsisTence and progression of\r\nMyeloProliferative Neoplasms" }, "short": "TARGET MPN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-06-01T02:00:00+02:00", "end_planned": "2028-01-01T01:00:00+01:00", "end_effective": "2028-07-10T02:00:00+02:00", "assignment": "2024-04-18T12:35:12+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 107132, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I06944", "ethics_committee": null, "edudract_number": null, "persons": [ "8142-107132-10", "8142-134381-12", "8142-101484-12", "8142-126596-12" ] }, { "id": 9299, "title": { "de": "Prädiktive Marker und Pathomechanismen der Krankheitsprogression bei Mycosis fungoides", "en": "Predictive markers and pathomechanisms of mycosis fungoides disease progression: Integrating Spatial Transcriptomics and In Situ Analysis of archived FFPE samples" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-10-01T02:00:00+02:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2027-09-30T02:00:00+02:00", "assignment": "2025-11-06T09:08:00+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 118468, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1161 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9299-118468-10" ] }, { "id": 8761, "title": { "de": "Innovative Ansätze für die Implantationsforschung in Gesundheit und Krankheit", "en": "Innovative approaches to implantation research in health and disease" }, "short": "IMPLANTEU", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2028-09-30T02:00:00+02:00", "assignment": "2025-04-09T16:15:10+02:00", "program": 209, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 1, "manager": 53232, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101169308", "ethics_committee": null, "edudract_number": null, "persons": [ "8761-53232-10" ] }, { "id": 9151, "title": { "de": "Traditionelle nigerianische Ernährung: Nachhaltige Wege zu besserer Gesundheit und Krankheitsprävention", "en": "Unlocking the potential of traditional Nigerian diets for sustainable nutrition and disease prevention" }, "short": "FERMENT-HEALTH", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-01-01T01:00:00+01:00", "begin_effective": "2026-01-01T01:00:00+01:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2027-12-31T01:00:00+01:00", "assignment": "2025-08-14T17:20:12+02:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 124253, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "P155", "ethics_committee": null, "edudract_number": null, "persons": [ "9151-124253-10" ] }, { "id": 8065, "title": { "de": "Digitalisierung von innovativen Pflegeprozessen \r\nzur Entlastung und Befähigung von Pflegekräften", "en": "Digitalisation of Innovative Care Processes \r\nto Unburden and Empower Nurses\r\n" }, "short": "N!CA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-03-01T01:00:00+01:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2028-02-29T01:00:00+01:00", "assignment": "2024-03-04T14:49:30+01:00", "program": 94, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 3, "manager": 65558, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "FO999904895", "ethics_committee": null, "edudract_number": null, "persons": [ "8065-54235-12", "8065-65558-10", "8065-99971-12", "8065-126174-12", "8065-134561-12" ] }, { "id": 9149, "title": { "de": "Probiotische Hefen und Nanotechnologie: Isolierung, Charakterisierung und neue Verabreichungssysteme für Gesundheits- und Lebensmittelanwendungen", "en": "Probiotic yeasts and nanotechnology: Isolation, characterization, and innovative delivery systems for health and food applications" }, "short": "PRONANO", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-01-01T01:00:00+01:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2027-10-31T02:00:00+02:00", "assignment": "2025-08-14T16:59:00+02:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 1, "manager": 124253, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "P153", "ethics_committee": null, "edudract_number": null, "persons": [ "9149-124253-10" ] }, { "id": 9540, "title": { "de": "Umweltfaktoren für den Schlaf: Ein bilateraler Ansatz für Review, Analyse und Forschungsplanung", "en": "Environmental determinants of sleep: A bilateral approach to review, research, and analytical planning" }, "short": "Environmental determinants of sleep", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-01-01T01:00:00+01:00", "begin_effective": "2026-01-01T01:00:00+01:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2027-12-31T01:00:00+01:00", "assignment": "2026-01-21T13:12:01+01:00", "program": 201, "subprogram": null, "organization": 14024, "category": 10, "type": 10, "partner_function": 1, "manager": 131598, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9540-131598-10" ] }, { "id": 7529, "title": { "de": "Impfbare Krankheiten bei schwangeren und stillenden Frauen", "en": "Vaccine preventable diseases in pregnant and lactating women" }, "short": null, "url": null, "abstract": { "de": "Given its effectiveness in protecting pregnant women, foetuses and infants from infectious diseases, maternal immunization has gained interest in recent years. Nevertheless, information on the optimal timing for this vaccination strategy is limited by the relatively poor understanding of the immunobiology of vaccine responses in pregnancy and during lactation. Dynamic changes in immune function occur during gestation that may affect vaccine response in pregnant women if vaccination is given at a different timepoint in pregnancy. Additionally, since several recommendations for vaccination in pregnancy or during lactation are currently in place or being made, the question arises whether the administration of different vaccines has an impact on the induction of the antibody-mediated immune responses and whether this possibly also influence the kinetics of these vaccine-induced antibodies. This implies that repeated sampling after vaccination is needed to describe and analyse antibody kinetics. However, the design of maternal immunization studies is typically informed by generic statistical approaches not dealing with questions as to when and how often samples should be taken in order to gather the right amount of information to investigate antibody kinetics.\r\n\r\nThe objectives are 1) to describe and compare kinetics of antibodies to two different vaccines (Tdap, COVID-19) and to investigate potential interactions; 2) to develop a framework to plan maternal immunization studies.\r\n\r\nIn two ongoing trials, serum and breastmilk samples are collected at several timepoints during and after pregnancy. In the Tdap trial, three cohorts of women are included differing in gestational age at which women are vaccinated with Tdap vaccine. In the COVID-19 trial, the effects of vaccinating pregnant and lactating women with a COVID-19 vaccine are investigated. In this project, we will measure antibody titres in blood and breastmilk samples for the vaccine not being the focus of the respective trial, i.e. getting in all samples information on Tdap and COVID-19. We will use mathematical models combined with statistical tools to analyse dynamic immune response and to improve the design of maternal immunization studies.\r\n\r\nThe main innovations are:1) comparing kinetic behaviour of antibodies induced by two different vaccines on several time points in serum and breastmilk; 2) investigating potential interactions of antibodies induced by two vaccines impacting the kinetics over time; 3) development of novel methodology to analyse and plan maternal immunization studies. Within this project, we focus on pertussis and COVID-19 as examples, but outcomes of this project can be applied to other infectious diseases for which vaccines can be administered in pregnancy or during lactation.", "en": "Aufgrund der hohen Anfälligkeit von Schwangeren, Föten und Säuglingen für Infektionskrankheiten hat die Immunisierung von Müttern in den letzten Jahren an Interesse gewonnen. Dennoch ist der optimale Zeitpunkt für eine Impfung in der Schwangerschaft noch immer unbekannt. Außerdem kommt es während der Schwangerschaft zu dynamischen Veränderungen der Immunfunktion, wenn ein Impfstoff zu einem anderen Schwangerschaftsalter verabreicht wird. Dies kann die Reaktion auf den Impfstoff und die Kinetik der durch den Impfstoff induzierten mütterlichen Antikörper im Blut und in der Muttermilch der Schwangeren beeinflussen.\r\n\r\nDa derzeit mehrere Empfehlungen für Impfungen in der Schwangerschaft gelten bzw. ausgesprochen werden, stellt sich außerdem die Frage, ob die Verabreichung verschiedener Impfstoffe in der Schwangerschaft Auswirkungen auf die Immunreaktionen auf diese Impfstoffe hat und möglicherweise eine Wechselwirkung in der Kinetik der durch verschiedene Impfstoffe induzierten Antikörper verursacht.\r\n\r\nIm Rahmen dieses Projekts wollen wir den optimalen Zeitpunkt für die Impfung in der Schwangerschaft bestimmen, die Antikörperkinetik vergleichen und mögliche Wechselwirkungen bei der Immunantwort untersuchen, wenn verschiedene Impfstoffe (z. B. Pertussis, COVID-19) in der Schwangerschaft verabreicht werden. Wir entwickeln konzeptionelle Rahmen, in denen wir statistische Ansätze mit mathematischen Modellen von Infektionskrankheiten kombinieren, um die Analyse und das Design von Studien zur mütterlichen Immunisierung zu verbessern.\r\n\r\nDer Schwerpunkt des Projekts liegt auf Pertussis und COVID-19, aber die Ergebnisse können auch auf andere Infektionskrankheiten angewendet werden, gegen die Impfstoffe in der Schwangerschaft verabreicht werden können." }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-06-01T02:00:00+02:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2028-05-31T02:00:00+02:00", "assignment": "2023-04-27T14:12:52+02:00", "program": 111, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 1, "manager": 83644, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I6376", "ethics_committee": null, "edudract_number": null, "persons": [ "7529-83644-10" ] }, { "id": 8325, "title": { "de": "XR2ESILIENCE - BAHNBRECHENDE XR-TECHNOLOGIE ZUR FÖRDERUNG DER RESILIENZ \r\nUND DER PSYCHISCHEN GESUNDHEIT DES GESUNDHEITSPERSONALS", "en": "XR2ESILIENCE - PIONEERING XR TECHNOLOGY FOR THE PROMOTION OF RESILIENCE \r\nAND MENTAL HEALTH OF THE HEALTHCARE WORKFORCE" }, "short": "XR2ESILIENCE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-12-01T01:00:00+01:00", "begin_effective": "2024-08-01T02:00:00+02:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2028-07-31T02:00:00+02:00", "assignment": "2024-08-05T12:40:49+02:00", "program": 211, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 3, "manager": 79733, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8325-79733-10" ] }, { "id": 8459, "title": { "de": "Succinat als Signalmolekül in der menschlichen Plazenta", "en": "Succinate as Signaling Molecule in the human Placenta" }, "short": "Succinat_Signalmolekül_menschlPlazenta", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2024-12-01T01:00:00+01:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2027-11-30T01:00:00+01:00", "assignment": "2024-10-21T11:54:18+02:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 51756, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT8808224", "ethics_committee": null, "edudract_number": null, "persons": [ "8459-51756-10", "8459-100879-11", "8459-106867-12", "8459-111587-12", "8459-132258-12" ] }, { "id": 8486, "title": { "de": "Unlocking RI potential with Scalable AI and Data", "en": "Unlocking RI potential with Scalable AI and Data" }, "short": "RI-SCALE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-03-01T01:00:00+01:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2028-02-29T01:00:00+01:00", "assignment": "2024-11-15T13:51:39+01:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 1, "manager": 99976, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8486-99976-10", "8486-108575-12", "8486-119452-12", "8486-125115-12", "8486-133220-12", "8486-133281-12" ] } ] }