Project List
List projects.
Fields
id (integer)
Primary key.
Expansions
To activate relation expansion add the desired fields as a comma separated
list to the expand query parameter like this:
?expand=<field>,<field>,<field>,...
The following relational fields can be expanded:
organizationcategorytypepartner_functionmanagercontactstatusgrantresearcheventstudylanguageprogramfunders
Filters
To filter for exact value matches:
?<fieldname>=<value>
Possible exact filters:
organizationcategorymanagercontactstatusgrantresearchstudylanguagefundersprogram
For advanced filtering use lookups:
?<fieldname>__<lookup>=<value>
All fields with advanced lookups can also be used for exact value matches as described above.
Possible advanced lookups:
begin_planned:gt,gte,lt,ltebegin_effective:gt,gte,lt,lteend_planned:gt,gte,lt,lteend_effective:gt,gte,lt,lte
GET /v1/research/project/?format=api&offset=240&ordering=-begin_effective
{ "count": 2260, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=260&ordering=-begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=220&ordering=-begin_effective", "results": [ { "id": 8133, "title": { "de": "Alterssuizid in Österreich: Eine Niedrig- und Hochrisikopopulationsstudie basierend auf verknüpften personenbezogenen Registerdaten", "en": "Suicide among older adults in Austria: A low- and high-risk population study based on linked individual-level register data" }, "short": "SAOAA", "url": "https://www.oeaw.ac.at/foerderungen/data-research-austria", "abstract": { "de": "Der Suizid eines Menschen ist eine Tragödie auf individueller Ebene und gleichzeitig ein Problem der öffentlichen Gesundheitsfürsorge auf gesellschaftlicher Ebene. Wenig bekannt ist dabei, dass die Suizidraten sowohl in Österreich als auch allen anderen europäischen Ländern stark mit dem Alter ansteigen. Die allerhöchsten Suizidraten finden sich bei hochaltrigen Männern. Österreich hat gegenwärtig eine der höchsten Suizidraten bei Hochaltrigen in ganz Europa und es wird erwartet, dass die absolute Zahl der Suizide bei älteren Menschen in den nächsten Dekaden aufgrund der fortschreitenden Überalterung der Bevölkerung, insbesondere durch das Älterwerden der Babyboomer-Generation, steigen wird. Die zentrale Forschungsfrage dieses Projekts ist daher, welche Risikofaktoren Suizide bei älteren Menschen in Österreich vorhersagen können, was in weiterer Folge dazu beitragen soll, Präventionsmaßnahmen zu verbessern. Vor dem Hintergrund erstmalig zugänglicher und auf individueller Ebene verknüpfbarer Registerdaten in Österreich durch das Austria Micro Data Center (AMDC) soll im Rahmen dieses Projekts untersucht werden, welche älteren Personengruppen ein erhöhtes Risiko für Suizid haben. Konkret planen wir Risikofaktoren in zwei Bevölkerungsgruppen zu untersuchen: (1) die gesamte ältere Allgemeinbevölkerung (Niedrigrisiko-Ansatz) und (2) ältere gerontopsychiatrische Patient*innen (Hochrisiko-Ansatz). Potentielle Risikofaktoren werden demographische und sozioökonomische Faktoren, körperliche und psychische Erkrankungen, Pflegebedürftigkeit und soziale Isolation umfassen. Dabei werden diese Risikofaktoren nicht nur isoliert voneinander betrachtet, sondern auch deren multiplikativer Effekt, d.h. wenn beispielsweise der Verlust eines Partners mit einer neuen Krebsdiagnose zusammenfällt, untersucht. Mit diesem Forschungsprojekt wollen wir den Alterssuizid in Österreich besser verstehen und damit eine bessere Grundlage für Präventionsmaßnahmen schaffen, und nicht zuletzt die Lebensumstände jener älteren Personen besser zu beleuchten, die keinen anderen Ausweg sehen, als sich selbst (oft mit Gewalt) das Leben zu nehmen. ", "en": "Suicide is a tragedy at the individual level and a serious public health problem at the societal level. Although often overlooked, suicide rates in both Austria and other European countries increase rapidly with age, so that the highest suicide rates tend to show among the oldest old, and here, specifically among men. Austria has one of the highest suicide rates among the oldest old within the EU-27 countries. The high number of suicide deaths among older adults in Austria is not only a present-day concern, but also worrying against the background of population ageing, specifically the ageing of the large baby boomer generation, as this will likely lead to an increase in the absolute number of suicides among older adults in the decades ahead. The main research question of this project therefore is what risk factors can predict old age suicides in Austria, which can subsequently inform suicide prevention efforts. Against the background of newly available individual-level register data linkage in Austria within the Austrian Micro Data Center (AMDC), the aim of this project is to provide new and hitherto unavailable evidence on who among the older population is at an elevated risk of suicide death. Specifically, we seek to identify risk factors in two populations: (1) the whole general older population (low-risk setting) and (2) older psychiatric inpatients (high-risk setting). Risk factors will include demographic and socioeconomic factors, physical and mental health problems, disability and social disconnectedness. We will not only look at these factors in isolation, but also assess whether there are multiplicative effects for suicide risk, that is, when multiple risk factors co-occur at the same time, e.g. when the loss of spouse coincides with a cancer diagnosis. With this research project, we aim to better understand old age suicide in Austria, to inform suicide prevention efforts, and to illuminate the life circumstances of those older adults who see no other way but to (often violently) end their own lives." }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2024-04-10T11:05:11+02:00", "program": 245, "subprogram": null, "organization": 14024, "category": 10, "type": 10, "partner_function": 1, "manager": 89152, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8133-89152-10", "8133-119651-12", "8133-128434-12" ] }, { "id": 8077, "title": { "de": "Smart FOX - Smart and Federated Open Data eXchange of citizen-based data donations for clinical research", "en": "Smart FOX - Smart and Federated Open Data eXchange of citizen-based data donations for clinical research" }, "short": "Smart FOX", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-12-01T01:00:00+01:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2025-11-30T01:00:00+01:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2024-03-08T10:12:02+01:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8077-51663-10" ] }, { "id": 8296, "title": { "de": "Qualitätsverbesserungsprojekt: Automatisiertes Reanimationsfeedback des Notarzteinsatzfahrzeugs Universitätsklinikum Graz", "en": "Quality improvement project: Automated resuscitation feedback from the physician response unit of the Medical University of Graz" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-07-01T02:00:00+02:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2025-07-01T02:00:00+02:00", "end_effective": "2026-02-01T01:00:00+01:00", "assignment": "2024-07-16T10:20:01+02:00", "program": null, "subprogram": null, "organization": 14069, "category": 10, "type": 10, "partner_function": 1, "manager": 95708, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8296-100227-12", "8296-60097-12", "8296-95708-10", "8296-97332-12", "8296-100461-12", "8296-99639-12" ] }, { "id": 8681, "title": { "de": "Smart and Federated Open data eXchange of citizen-based data donations for clinical research", "en": "Smart and Federated Open data eXchange of citizen-baseddata donations for clinical research " }, "short": "SmartFOX", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2025-02-24T16:54:03+01:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 1, "manager": 99976, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8681-99976-10" ] }, { "id": 8243, "title": { "de": "Nach der Geburt durchgeführte neonatologische Lungenultraschalluntersuchungen zur Prognose der Notwendigkeit einer Atemunterstützung >60 Lebensminuten", "en": "Neonatologist-performed lung ultrasound during immediate transition after birth to predict the need for respiratory support persisting more than 1 hour" }, "short": "Lung Ultrasound in the Delivery Room", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-03-01T01:00:00+01:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2027-02-28T01:00:00+01:00", "end_effective": "2027-06-30T02:00:00+02:00", "assignment": "2024-06-10T11:34:36+02:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 79516, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8243-79516-10", "8243-86558-11" ] }, { "id": 8456, "title": { "de": "Recycling von multifunktionalen Carbonsäurebausteinen durch Erweiterung des Substratfensters von Enzymen", "en": "Recycling of multi-functional carboxylic acid building blocks by enzyme substrate window expansion" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-07-01T02:00:00+02:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2027-06-30T02:00:00+02:00", "end_effective": "2027-06-30T02:00:00+02:00", "assignment": "2024-10-18T15:12:16+02:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 2, "manager": 107189, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8456-107189-10" ] }, { "id": 8504, "title": { "de": "European Federation for Cancer Images", "en": "European Federation for Cancer Images" }, "short": "EUCAIM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-11-19T14:02:04+01:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 1, "manager": 99976, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8504-99976-10", "8504-133200-12", "8504-133281-12" ] }, { "id": 8433, "title": { "de": "Next Generation NMR-based Metabolomics", "en": "Next Generation NMR-based Metabolomics" }, "short": "NextGen metNMR", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-07-01T02:00:00+02:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2027-06-30T02:00:00+02:00", "end_effective": "2027-06-30T02:00:00+02:00", "assignment": "2024-10-08T13:23:25+02:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 3, "manager": 91207, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8433-91207-10" ] }, { "id": 8333, "title": { "de": "Assessment of the cardiovascular risk profile of infants exposed to pre-eclampsia in utero", "en": "Assessment of the cardiovascular risk profile of infants exposed to pre-eclampsia in utero" }, "short": "CARIPRE-ECLAMPSIA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-07-01T02:00:00+02:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2026-06-30T02:00:00+02:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2024-08-08T11:09:42+02:00", "program": 254, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 3, "manager": 57932, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8333-57932-10" ] }, { "id": 8189, "title": { "de": "Orphan Device für pädiatrische Patienten: eine einzigartige Plattform mit innovativen Dienstleistungen", "en": "Orphan Device for paediatric patients: a unique platform providing innovative services" }, "short": "OrphaDev4kids", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2028-01-01T01:00:00+01:00", "end_effective": "2027-06-30T02:00:00+02:00", "assignment": "2024-05-08T10:42:03+02:00", "program": null, "subprogram": "EU4H-2023-PJ", "organization": 14052, "category": 10, "type": 10, "partner_function": 2, "manager": 50785, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101161377", "ethics_committee": null, "edudract_number": null, "persons": [ "8189-50785-10" ] }, { "id": 8295, "title": { "de": "Auswirkung von CD8+ T-Zelldepletion auf das Tumormikromilieu (TME) bei Nr4a1-Verlust", "en": "Effect of CD8+ T cell depletion on the tumour microenvironment (TME) in Nr4a1 loss" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-07-01T02:00:00+02:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2025-02-28T01:00:00+01:00", "end_effective": "2025-02-28T01:00:00+01:00", "assignment": "2024-07-11T11:00:10+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 100134, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": "FIF-A 16-0477/212007029", "ethics_committee": null, "edudract_number": null, "persons": [ "8295-100134-10", "8295-111069-12" ] }, { "id": 8656, "title": { "de": "Bile acid-HDL conjugates ameliorate obesity associated endothelial dysfunction", "en": "Bile acid-HDL conjugates ameliorate obesity associated endothelial dysfunction" }, "short": "BAED", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-07-01T02:00:00+02:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2025-06-30T02:00:00+02:00", "end_effective": "2025-06-30T02:00:00+02:00", "assignment": "2025-02-13T11:39:55+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 98847, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8656-98847-10" ] }, { "id": 8267, "title": { "de": "Hans Salzer Preis der Österreichischen Gesellschaft für Kinder- und Jugendchirurgie", "en": "Hans Salzer Preis of the Austrian Association of Pediatric and Adolescent Surgery" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-06-18T02:00:00+02:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-06-18T13:01:08+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 102332, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1567 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8267-102332-10" ] }, { "id": 8275, "title": { "de": "Pilotstudie zum Vokalisationsverhalten von Babys mit Regulationsproblemen", "en": "Pilotstudie zum Vokalisationsverhalten von Babys mit Regulationsproblemen" }, "short": null, "url": null, "abstract": { "de": "Die Pilotstudie beschäftigt sich mit Babys mit Regulationsproblemen. Dies sind Babys, welche in den vergangenen 3 Wochen an mindestens 3 Tagen pro Woche 3 oder mehr Stunden geweint haben (\"Wessel-Kriterien\"); sie werden häufig auch als \"Schreibabys\" bezeichnet. Wissenschaftliche Studien zeigten, dass Kinder, die als Babys Regulationsprobleme hatten, später häufiger Verhaltens- und Entwicklungsauffälligkeiten haben als Kinder, die als Babys keine Regulationsprobleme hatten. Ob solche Probleme auftreten werden lässt sich im Babyalter aktuell nicht vorhersagen, zumal es bislang auch kaum Untersuchungen dazu gibt, wie sich Babys mit Regulationsproblemen – abgesehen von der Schreihäufigkeit – in den ersten Lebensmonaten verhalten. Der vorrangige Zweck dieser Pilotstudie ist es,\r\nLautäußerungen von Babys mit Regulationsproblemen und Babys ohne Regulationsprobleme im Alter von 8 bis 10 Wochen zu analysieren und erste Vergleiche anzustellen. Die Ergebnisse könnten Hinweise auf Abweichungen im vorsprachlichen Verhalten von Kindern mit Regulationsproblemen liefern. Die gewonnenen Erkenntnisse über potentiell geeignete Parameter könnten in Folgestudien dazu beitragen, Babys zu identifizieren, die ein erhöhtes Risiko für persistierende Regulationsprobleme bzw. oftmals damit einhergehende Verhaltens- und Entwicklungsdefizite haben. Die Rekrutierung für die Studie erfolgt in Zusammenarbeit mit dem Ärztlichen Dienst der Stadt Graz.", "en": null }, "begin_planned": "2024-05-01T02:00:00+02:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-06-26T16:44:08+02:00", "program": null, "subprogram": null, "organization": 14068, "category": 10, "type": 10, "partner_function": 4, "manager": 77049, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": "FIF-A 16-0451/2024-0001", "ethics_committee": null, "edudract_number": null, "persons": [ "8275-50573-12", "8275-79651-12", "8275-83581-12", "8275-91531-12", "8275-77049-10" ] }, { "id": 8276, "title": { "de": "Weiterentwicklung und Erweiterung einer Kryobank humaner laryngealer Zelllinien und des Ursprungsgewebes", "en": "Further development and expansion of a cryobank of human laryngeal cell lines and the tissue of origin" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-06-30T02:00:00+02:00", "begin_effective": "2024-06-30T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-06-26T16:55:23+02:00", "program": null, "subprogram": null, "organization": 14068, "category": 10, "type": 10, "partner_function": 4, "manager": 82902, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8276-50670-11", "8276-82902-10", "8276-88652-12", "8276-103118-12", "8276-116882-12" ] }, { "id": 8390, "title": { "de": "Intermittierendes Fasten und Bewegung bei Typ 2 Diabetes", "en": "Intermittent Fasting and Exercise in Type 2 Diabetes" }, "short": "INTERFAST-3", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-06-15T02:00:00+02:00", "begin_effective": "2024-06-15T02:00:00+02:00", "end_planned": "2027-06-14T02:00:00+02:00", "end_effective": "2028-06-14T02:00:00+02:00", "assignment": "2024-09-17T12:19:28+02:00", "program": 108, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 50838, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLP3413324", "ethics_committee": null, "edudract_number": null, "persons": [ "8390-50838-10" ] }, { "id": 8235, "title": { "de": "LYMPHO-CHECK: Lymphoma Mausmodelle und funktionelle Genomik", "en": "LYMPHO-CHECK: Lympha mouse models and functional genomics" }, "short": "LYMPHO-CHECK", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-06-03T02:00:00+02:00", "end_planned": "2029-12-31T01:00:00+01:00", "end_effective": "2029-06-02T02:00:00+02:00", "assignment": "2024-06-03T14:29:07+02:00", "program": 113, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 89979, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "FG 30", "ethics_committee": null, "edudract_number": null, "persons": [ "8235-89979-10" ] }, { "id": 8233, "title": { "de": "Die Nr4a1/P53 Achse in der Immun Evasion von Lymphomen", "en": "NR4A1-P53 AXIS IN THE IMMUNE EVASION OF AGGRESSIVE LYMPHOMAS" }, "short": "LYMPHO-CHECK", "url": null, "abstract": { "de": "Aggressive Lymphome gehören zu den häufigsten Arten von Lymphdrüsenkrebs und stellen eine große Herausforderung für die Behandlung dar. Checkpoint-Blockade-Therapien (CBTs) haben sich als vielversprechender Weg erwiesen, um der Umgehung der Anti-Tumor-Immunantwort durch den Tumor entgegenzuwirken. Trotz ihres Potenzials sind CBTs mit erheblichen Kosten verbunden und basieren häufig auf Trial-and-Error-Ansätzen. Zudem sprechen nur ein kleiner Prozentsatz der Lymphom-Patienten (10-20%) auf CBT an, teilweise aufgrund eines Mangels an Verständnis darüber, wie Immun-Checkpoints während der Entwicklung von Lymphomen reguliert werden, sowie aufgrund des Fehlens prädiktiver Biomarker. Unsere jüngsten Forschungsergebnisse haben wichtige Faktoren aufgedeckt, die zu schlechten Ergebnissen bei Patienten mit diffusen großzelligen B-Zell-Lymphomen (DLBCL) beitragen. Wir beobachteten signifikante Abnahmen der NR4A1- und p53-Spiegel, die wichtige Regulatoren der Genexpression sind, vergesellschaftet mit erhöhten Checkpoint-Komponenten-Gehalt. Bei Mäusen führte die Deletion von NR4A1 zu reduzierten p53-Spiegeln, beschleunigter Lymphomentwicklung und erhöhter Expression von immuninhibitorischen Checkpoint-Komponenten. Diese Ergebnisse deuten auf eine funktionelle Beziehung zwischen NR4A1 und p53, die in der Immunantwort auf Tumore die Expression von Checkpoint-Komponenten in aggressiven Lymphomen reguliert.\r\nUnser vorgeschlagenes Forschungsprojekt zielt darauf ab, diese Herausforderungen durch die Entwicklung neuer Mausmodelle mit spezifischen Deletionen von NR4A1 und/oder p53 in B-Zellen anzugehen. Unter Verwendung fortschrittlicher molekularer und genomweiter Techniken werden wir umfassend untersuchen, wie Lymphome in diesen Modellen entstehen. Außerdem werden wir eine Methode zur wiederholten Gewebsflüssigkeitsentnahme adaptieren und damit wiederholte Messungen von Zytokinsignalen und zellulären Veränderungen in sich entwickelnden Tumoren durchführen, wodurch wertvolle Einblicke in das Lymphom-Mikromilieu gewonnen werden. Mit Hilfe dieser Modelle hoffen wir, neue Checkpoint-Blockade-Therapien für aggressive Lymphom entwickeln und auf den Status von NR4A1 und p53 abstimmen zu können. Zur Validierung unserer Ergebnisse werden wir eine große Kohorte von Lymphomproben von Patienten analysieren und mit öffentlich verfügbaren Datensätzen vergleichen. Letztendlich ist es unser Ziel, die klinische Relevanz der NR4A1-p53-Checkpoint-Achse zu bewerten und neue Biomarker zu identifizieren, die bei aggressiven Lymphomen als Entscheidungshilfe für die Behandlung mit Checkpoint-Inhibitoren dienen können. Durch unsere Forschung wollen wir die Ergebnisse für Patienten mit aggressiven Lymphomen verbessern, indem wir wirksamere und personalisierte Behandlungsstrategien entwickeln.\r\n", "en": "Aggressive lymphomas are among the most common types of lymphoid cancers and consist of Burkitt’s lymphoma, diffuse large B cell lymphoma (DLBCL), follicular lymphoma grade 3. While checkpoint blockade therapies (CBTs) have emerged as a promising avenue to counteract tumor evasion, this treatment form comes with substantial cost burdens and often rely on trial-and-error approaches. Importantly, only a small percentage of lymphoma patients (10-20%) respond favorably to CBT, partly due to the limited understanding of the regulation of immune checkpoints during lymphoma development and the absence of predictive biomarkers. Our recent investigations have shed light on key factors contributing to poor outcomes in patients with DLBCL. We observed significant decreases in the levels of NR4A1 and p53, which are important regulators of gene expression and known tumor suppressors, alongside high expression of checkpoint components. In mice, depletion of NR4A1 led to reduced p53 levels, accelerated lymphoma development, and increased expression of immune-inhibitory checkpoint components, particularly in animals with intact immune systems. These and other findings suggest a functional relationship involving NR4A1, p53, and the orchestrating immune evasive mechanisms in aggressive lymphomas.\r\nOur proposed research project aims to address this axis by developing new mouse models with specific and inducible deletion of NR4A1 and/or p53 in B cells. Using advanced molecular and genomic techniques, we will comprehensively study lymphoma development in these models. We will also implement a tissue fluid sampling method to repeatedly measure cytokine signals and cellular changes within evolving tumors, providing valuable insights into the lymphoma microenvironment. By leveraging these models, we aim to tailor CBTs based on the status of NR4A1 and p53. To clinically validate our findings, we will analyze a large cohort of lymphoma samples from GRAZ lymphoma cohort and compare them with publicly available datasets. Ultimately, our goal is to functionally establish the clinical relevance of the NR4A1-p53-checkpoint axis and identify new biomarkers that can help guide treatment decisions involving checkpoint inhibitors for aggressive lymphomas. Through our research, we are poised to improve outcomes for patients with aggressive lymphomas by developing more effective and personalized treatment strategies.\r\n" }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-06-03T02:00:00+02:00", "end_planned": "2028-12-31T01:00:00+01:00", "end_effective": "2029-06-02T02:00:00+02:00", "assignment": "2024-06-03T13:00:14+02:00", "program": 113, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 3, "manager": 59183, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "FG 30", "ethics_committee": null, "edudract_number": null, "persons": [ "8233-100134-12", "8233-59183-10", "8233-79614-12", "8233-82501-12", "8233-85928-12", "8233-111069-12", "8233-102513-12", "8233-132158-12", "8233-122350-12" ] }, { "id": 8236, "title": { "de": "LYMPHO-CHECK: Bioinformatik und Data-Mining in der Lymphomforschung\r\n ", "en": "LYMPHO-CHECK: Bioinformatics and Data Mining in Lymphoma Research" }, "short": "LYMPHO-CHECK", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-06-03T02:00:00+02:00", "end_planned": "2028-12-31T01:00:00+01:00", "end_effective": "2029-06-02T02:00:00+02:00", "assignment": "2024-06-03T14:29:51+02:00", "program": 113, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 94195, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "FG 30", "ethics_committee": null, "edudract_number": null, "persons": [ "8236-94195-10" ] }, { "id": 8562, "title": { "de": "Pilotprojekt Telemedizin in der klinisch-forensischen Untersuchung", "en": "-" }, "short": "Telemedizin_klin-foren_Untersuchungen", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-07-01T02:00:00+02:00", "begin_effective": "2024-06-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-12-12T14:49:41+01:00", "program": null, "subprogram": null, "organization": 14019, "category": 10, "type": 10, "partner_function": 4, "manager": 115441, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8562-115441-10" ] } ] }