Project List
List projects.
Fields
id (integer)
Primary key.
Expansions
To activate relation expansion add the desired fields as a comma separated
list to the expand query parameter like this:
?expand=<field>,<field>,<field>,...
The following relational fields can be expanded:
organizationcategorytypepartner_functionmanagercontactstatusgrantresearcheventstudylanguageprogramfunders
Filters
To filter for exact value matches:
?<fieldname>=<value>
Possible exact filters:
organizationcategorymanagercontactstatusgrantresearchstudylanguagefundersprogram
For advanced filtering use lookups:
?<fieldname>__<lookup>=<value>
All fields with advanced lookups can also be used for exact value matches as described above.
Possible advanced lookups:
begin_planned:gt,gte,lt,ltebegin_effective:gt,gte,lt,lteend_planned:gt,gte,lt,lteend_effective:gt,gte,lt,lte
GET /v1/research/project/?format=api&offset=2280&ordering=begin_planned
{ "count": 2323, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=2300&ordering=begin_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=2260&ordering=begin_planned", "results": [ { "id": 2793, "title": { "de": "Anschaffung einer Infrastruktur zur Dokumentation und quantitativen markierungsfreien mikroskopischen Erfassung physiologischer Zellvorgänge", "en": "Anschaffung einer Infrastruktur zur Dokumentation und quantitativen markierungsfreien mikroskopischen Erfassung physiologischer Zellvorgänge" }, "short": "EFRE", "url": null, "abstract": { "de": "Manche Zellveränderungen lassen sich anhand des Gehaltes bestimmter Zellbestandteile, der Aktivität von Enzymen oder der Bindung bestimmter Farbstoffe erkennen. Am besten lassen sich zelluläre Vorgänge wie Zellteilung, Formveränderungen und Absterben von Zellen aber über die Beobachtung ungefärbter Zellen im Mikroskop erfassen, da es hier nicht zum Zusatz möglicherweise beeinflussender Substanzen kommt. Der Nachteil der mikroskopischen Auswertung ist, dass die Beurteilung sehr zeitaufwendig ist, nie alle Zellen erfassen kann und nicht standardisiert abläuft. Zusätzlich kam in der Vergangenheit hinzu, dass die Beobachtung im Mikroskop nur am Ende des Versuches möglich war, denn die Zellen mussten dazu aus dem Brutschrank genommen werden. Dadurch waren sie einem Temperaturschock und einer Veränderung der Atmosphäre ausgesetzt und hörten damit auf zu wachsen. Je nach Länge der Untersuchung fanden Abbauvorgänge in der Zelle statt, die das Ergebnis verfälschen konnten. Neuere Entwicklungen im mikroskopischen Bereich haben dazu geführt, dass Verlaufstudien möglich sind, indem eine Dokumentation von Zellen in einem dem Brutschrank ähnlichen Milieu möglich wurde. Die fehlende Quantifizierung dieser Veränderungen stellt jedoch weiterhin ein Problem dar. Im Projekt soll daher eine long-term Imaging Gerät angeschafft werden, welches sich teilende Zellen von absterbenden Zellen anhand der damit verbundenen dynamischen morphologischen Veränderungen unterscheiden kann und die prozentuale Verteilung von ruhenden, teilenden und sterbenden Zellen darstellen kann. Weiters kann das Gerät physiologische Veränderungen quantifizieren als beispielsweise die Richtung und Strecke bestimmter Zellwanderungen oder die Länge von Fortsätzen bestimmen. So lassen sich Veränderungen von Zellen, die verschiedenen Stimulationen ausgesetzt wurden über mehrere Tage im Brutschrank nicht nur beobachten und dokumentieren, sondern auch quantifizieren. Dies stellt eine entscheidende Weiterentwicklung in der mikroskopischen Auswertung von Zellvorgängen dar.", "en": "Manche Zellveränderungen lassen sich anhand des Gehaltes bestimmter Zellbestandteile, der Aktivität von Enzymen oder der Bindung bestimmter Farbstoffe erkennen. Am besten lassen sich zelluläre Vorgänge wie Zellteilung, Formveränderungen und Absterben von Zellen aber über die Beobachtung ungefärbter Zellen im Mikroskop erfassen, da es hier nicht zum Zusatz möglicherweise beeinflussender Substanzen kommt. Der Nachteil der mikroskopischen Auswertung ist, dass die Beurteilung sehr zeitaufwendig ist, nie alle Zellen erfassen kann und nicht standardisiert abläuft. Zusätzlich kam in der Vergangenheit hinzu, dass die Beobachtung im Mikroskop nur am Ende des Versuches möglich war, denn die Zellen mussten dazu aus dem Brutschrank genommen werden. Dadurch waren sie einem Temperaturschock und einer Veränderung der Atmosphäre ausgesetzt und hörten damit auf zu wachsen. Je nach Länge der Untersuchung fanden Abbauvorgänge in der Zelle statt, die das Ergebnis verfälschen konnten. Neuere Entwicklungen im mikroskopischen Bereich haben dazu geführt, dass Verlaufstudien möglich sind, indem eine Dokumentation von Zellen in einem dem Brutschrank ähnlichen Milieu möglich wurde. Die fehlende Quantifizierung dieser Veränderungen stellt jedoch weiterhin ein Problem dar. Im Projekt soll daher eine long-term Imaging Gerät angeschafft werden, welches sich teilende Zellen von absterbenden Zellen anhand der damit verbundenen dynamischen morphologischen Veränderungen unterscheiden kann und die prozentuale Verteilung von ruhenden, teilenden und sterbenden Zellen darstellen kann. Weiters kann das Gerät physiologische Veränderungen quantifizieren als beispielsweise die Richtung und Strecke bestimmter Zellwanderungen oder die Länge von Fortsätzen bestimmen. So lassen sich Veränderungen von Zellen, die verschiedenen Stimulationen ausgesetzt wurden über mehrere Tage im Brutschrank nicht nur beobachten und dokumentieren, sondern auch quantifizieren. Dies stellt eine entscheidende Weiterentwicklung in der mikroskopischen Auswertung von Zellvorgängen dar." }, "begin_planned": null, "begin_effective": "2009-06-10T02:00:00+02:00", "end_planned": null, "end_effective": "2010-05-31T02:00:00+02:00", "assignment": null, "program": null, "subprogram": "EFRE ", "organization": 17230, "category": 10, "type": 10, "partner_function": 4, "manager": 53900, "contact": 53900, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10, 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2793-53900-10" ] }, { "id": 223, "title": { "de": "Plazenta, Fettsäuren und Diabetes", "en": "Plazenta, Fettsäuren und Diabetes" }, "short": "Plazenta, Fettsäuren und Diabetes", "url": null, "abstract": { "de": "Plazenta, Fettsäuren und Diabetes.", "en": "Plazenta, Fettsäuren und Diabetes." }, "begin_planned": null, "begin_effective": "2002-12-12T01:00:00+01:00", "end_planned": null, "end_effective": "2004-12-31T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 79, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 51632, "contact": 51632, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "223-51632-10" ] }, { "id": 1374, "title": { "de": "SFB LIPOTOX: Teilprojekt des Koordinationsprojekts (Pathophysiologischer Teil)", "en": "SFB LIPOTOX: Teilprojekt des Koordinationsprojekts (Pathophysiologischer Teil)" }, "short": "SFB_LIPOTOX_Höfler", "url": null, "abstract": { "de": "The goal of the SFB-LIPOTOX is to elucidate the molecular and cellular\r\nprocesses and pathways behind the conversion of physiological substrates,\r\nsuch as FA and lipids into noxious compounds, their effects on cell and\r\norgan function and dysfunction, and their contribution to various forms of\r\ncell death. \r\nThe conversion of FA and lipids into lipotoxic substances occurs via two\r\nprocesses: First, substrate overload, as defined by the excessive cellular\r\nuptake of FA and lipids that exceeds the oxidative capacity of target cells.\r\nSecond, the chemical conversion and modification of FA and lipid substrates\r\ngenerating biologically active signaling molecules of high toxic potential,\r\ne.g. ceramide, lysophospholipids, lipid oxidation products, or ROS. Within\r\nthe SFB-LIPOTOX we propose to identify presently unknown lipotoxic compounds\r\nby a mass spectrometry (MS) based lipidomic approach, to study the molecular\r\nmechanisms of their biosynthesis and inactivation, and to elucidate the resulting biological responses in genetically modified model organisms. \r\nWe will:\r\n*identify and characterize enzymatic processes that generate or catabolize signalling lipids;\r\n*study the mechanisms by which FA and lipotoxic lipids affect cell signalling;\r\n*examine lipid modification processes and their role in lipotoxicity;\r\n*characterize the involvement of genes and their protein products in lipotoxic pathways;\r\n*uncover lipotoxic effects on cell and organ function and lipid-induced cell death;\r\nrelate our findings in model organisms to the pathogenesis of human diseases, such as insulin resistance, atherosclerosis, and neurodegenerative disorders.\r\n\r\nTo achieve these goals, it is necessary to combine a broad spectrum of\r\nscientific and methodological expertise from various fields in biomedicine:\r\nlipid biology, signal transduction, cell organelle function, and apoptosis\r\nresearch. Accordingly, we assembled an interdisciplinary research consortium\r\non the basis of scientific excellence, plus a keen interest in, and a strong\r\ncommitment to the goals of the SFB-LIPOTOX. All principal investigators have\r\na strong scientific track record, contribute important biological model\r\nsystems required for the project, and possess the technical expertise\r\nrequired for the proposed research. The combined expertise of the consortium\r\nmembers will provide a unique opportunity to investigate lipotoxic pathways\r\non a large scale across species, tissues, and conditions.\r\nWithin the initial funding period of the SFB-LIPOTOX (4 years) we expect to\r\ndiscover unknown lipid species involved in signaling, enzymes and metabolic\r\nprocesses that generate or inactivate (degrade) signalling lipids, and the\r\nconsequences of lipid signalling on cell dysfunction and death. Long term\r\ngoals beyond the initial project period include the elucidation of the\r\ndetailed physiological function of our discoveries, their contribution to\r\nlipid and energy metabolism, and their potential application in the\r\ndiagnosis and treatment of human disease.\r\n", "en": "The goal of the SFB-LIPOTOX is to elucidate the molecular and cellular\r\nprocesses and pathways behind the conversion of physiological substrates,\r\nsuch as FA and lipids into noxious compounds, their effects on cell and\r\norgan function and dysfunction, and their contribution to various forms of\r\ncell death. \r\nThe conversion of FA and lipids into lipotoxic substances occurs via two\r\nprocesses: First, substrate overload, as defined by the excessive cellular\r\nuptake of FA and lipids that exceeds the oxidative capacity of target cells.\r\nSecond, the chemical conversion and modification of FA and lipid substrates\r\ngenerating biologically active signaling molecules of high toxic potential,\r\ne.g. ceramide, lysophospholipids, lipid oxidation products, or ROS. Within\r\nthe SFB-LIPOTOX we propose to identify presently unknown lipotoxic compounds\r\nby a mass spectrometry (MS) based lipidomic approach, to study the molecular\r\nmechanisms of their biosynthesis and inactivation, and to elucidate the resulting biological responses in genetically modified model organisms. \r\nWe will:\r\n*identify and characterize enzymatic processes that generate or catabolize signalling lipids;\r\n*study the mechanisms by which FA and lipotoxic lipids affect cell signalling;\r\n*examine lipid modification processes and their role in lipotoxicity;\r\n*characterize the involvement of genes and their protein products in lipotoxic pathways;\r\n*uncover lipotoxic effects on cell and organ function and lipid-induced cell death;\r\nrelate our findings in model organisms to the pathogenesis of human diseases, such as insulin resistance, atherosclerosis, and neurodegenerative disorders.\r\n\r\nTo achieve these goals, it is necessary to combine a broad spectrum of\r\nscientific and methodological expertise from various fields in biomedicine:\r\nlipid biology, signal transduction, cell organelle function, and apoptosis\r\nresearch. Accordingly, we assembled an interdisciplinary research consortium\r\non the basis of scientific excellence, plus a keen interest in, and a strong\r\ncommitment to the goals of the SFB-LIPOTOX. All principal investigators have\r\na strong scientific track record, contribute important biological model\r\nsystems required for the project, and possess the technical expertise\r\nrequired for the proposed research. The combined expertise of the consortium\r\nmembers will provide a unique opportunity to investigate lipotoxic pathways\r\non a large scale across species, tissues, and conditions.\r\nWithin the initial funding period of the SFB-LIPOTOX (4 years) we expect to\r\ndiscover unknown lipid species involved in signaling, enzymes and metabolic\r\nprocesses that generate or inactivate (degrade) signalling lipids, and the\r\nconsequences of lipid signalling on cell dysfunction and death. Long term\r\ngoals beyond the initial project period include the elucidation of the\r\ndetailed physiological function of our discoveries, their contribution to\r\nlipid and energy metabolism, and their potential application in the\r\ndiagnosis and treatment of human disease.\r\n" }, "begin_planned": null, "begin_effective": "2007-04-01T02:00:00+02:00", "end_planned": null, "end_effective": "2011-03-31T02:00:00+02:00", "assignment": "2007-10-04T17:55:13+02:00", "program": 67, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51691, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "F30", "ethics_committee": null, "edudract_number": null, "persons": [ "1374-51691-10" ] }, { "id": 482, "title": { "de": "Defective DNA-Repair in acute myeloid leukemia", "en": "Defective DNA-Repair in acute myeloid leukemia" }, "short": "Defective DNA-Repair ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": null, "begin_effective": "2005-09-05T02:00:00+02:00", "end_planned": null, "end_effective": "2009-09-03T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51857, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "482-51857-10" ] }, { "id": 131, "title": { "de": "PERILIP: Influence of dietary fatty acids on the pathophysiology of intrauterine foetal growth and neonatal development", "en": "PERILIP: Influence of dietary fatty acids on the pathophysiology of intrauterine foetal growth and neonatal development" }, "short": "PERILIP", "url": null, "abstract": { "de": "Perinatal nutrition is known to affect the health and development of the newborn child. A foetus that suffers from intra-uterine growth restriction (IUGR) is more likely to suffer from cardiac or diabtetic problems in later life, an effect known as \"metabolic programming\". Particular fatty acids are required for development but the optimum composition of dietary lipids remains controversial. The project will compare normal and IUGR pregnancies in terms of matter, neonatal and placenta fatty acid profiles. Placental transfer of fatty acids in vivo and the funcional ability of trophoblasts in vitro will be measured. The effects of dietary fats, on maternal endocrine status, oxidative stress, milk composition, placental function and on the development of IUGR and normal foetuses in utero (or ex utero in the case of the pretern infants fed intravenously) will be assessed. Human's studies will be complemented with appropriate rat and pig animal-models. The results will be used to formulate improved dietary recommendations for mothers throughout pregnancy and lactation. ", "en": "Perinatal nutrition is known to affect the health and development of the newborn child. A foetus that suffers from intra-uterine growth restriction (IUGR) is more likely to suffer from cardiac or diabtetic problems in later life, an effect known as \"metabolic programming\". Particular fatty acids are required for development but the optimum composition of dietary lipids remains controversial. The project will compare normal and IUGR pregnancies in terms of matter, neonatal and placenta fatty acid profiles. Placental transfer of fatty acids in vivo and the funcional ability of trophoblasts in vitro will be measured. The effects of dietary fats, on maternal endocrine status, oxidative stress, milk composition, placental function and on the development of IUGR and normal foetuses in utero (or ex utero in the case of the pretern infants fed intravenously) will be assessed. Human's studies will be complemented with appropriate rat and pig animal-models. The results will be used to formulate improved dietary recommendations for mothers throughout pregnancy and lactation. " }, "begin_planned": null, "begin_effective": "2002-04-01T02:00:00+02:00", "end_planned": null, "end_effective": "2005-09-30T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 20, "subprogram": "Quality of Life", "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 51632, "contact": 51632, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "131-51632-10" ] }, { "id": 303, "title": { "de": "Wilson Disease: Creating a European Clinical Database and designing randomised controlled clinical trials", "en": "Wilson Disease: Creating a European Clinical Database and designing randomised controlled clinical trials" }, "short": "EuroWilson", "url": null, "abstract": { "de": "Wilson disease is an autosomal recessive disorder in which deficiency of a copper-transporting trans-golgi P-type ATPase leads to intracellular retention of copper and hence hepatic, neurological & renal disease. Incidence estimates vary from 1:30000 to 1:100000. Mutation identification aids early diagnosis. Although there is encouraging single centre experience with copper-chelators (BAL in early work, now penicillamine or trientine), zinc sulfate of acetate, or ammonium tetrathiomolybdate, treatment dilemmas remain. We do not know how to treat pre-symptomatically diagnosed infants. There is a lack of randomised controlled clinical trials (RCTs). Initial neurological deterioration on starting treatment may not be reversible. Long term outlook is uncertain. A small survey of clinicians revealed wide differences in treatment choices and lack of certainty about optimum treatment. A Cochrane-style literature review found virtually no Level I evidence. A multicentre stratified RCT is necessary. In 2002 the European Society of Paediatric Gastroeneterology, Hepatology and Nutrition established a working group of paediatric and adult hepatologists and neurologists with representation from the European Society for the Study of the Liver and the Movement Disorder Society. This has concluded that mounting an RCT is not possible without data on the incidence, prevalence of sub-types, current treatments, and short term outcomes. The consortium wishes to establish a European Clinical Database, data from which will inform the process of setting up an RCT. Preliminary work has addressed diagnostic criteria, database items, choice of software, database host, and secure access. The aims of the project are to set up the database, collect and analyse 1 year's data, set up an RCT planning group and workshop, and to continue data collection and patient monitoring for 4 years.", "en": "Wilson disease is an autosomal recessive disorder in which deficiency of a copper-transporting trans-golgi P-type ATPase leads to intracellular retention of copper and hence hepatic, neurological & renal disease. Incidence estimates vary from 1:30000 to 1:100000. Mutation identification aids early diagnosis. Although there is encouraging single centre experience with copper-chelators (BAL in early work, now penicillamine or trientine), zinc sulfate of acetate, or ammonium tetrathiomolybdate, treatment dilemmas remain. We do not know how to treat pre-symptomatically diagnosed infants. There is a lack of randomised controlled clinical trials (RCTs). Initial neurological deterioration on starting treatment may not be reversible. Long term outlook is uncertain. A small survey of clinicians revealed wide differences in treatment choices and lack of certainty about optimum treatment. A Cochrane-style literature review found virtually no Level I evidence. A multicentre stratified RCT is necessary. In 2002 the European Society of Paediatric Gastroeneterology, Hepatology and Nutrition established a working group of paediatric and adult hepatologists and neurologists with representation from the European Society for the Study of the Liver and the Movement Disorder Society. This has concluded that mounting an RCT is not possible without data on the incidence, prevalence of sub-types, current treatments, and short term outcomes. The consortium wishes to establish a European Clinical Database, data from which will inform the process of setting up an RCT. Preliminary work has addressed diagnostic criteria, database items, choice of software, database host, and secure access. The aims of the project are to set up the database, collect and analyse 1 year's data, set up an RCT planning group and workshop, and to continue data collection and patient monitoring for 4 years." }, "begin_planned": null, "begin_effective": "2004-06-01T02:00:00+02:00", "end_planned": null, "end_effective": "2008-08-31T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 21, "subprogram": null, "organization": 14048, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 292, "title": { "de": "AT-0042 Image Processing, Information Engineering & Interdisciplinary Knowledge Exchange", "en": "AT-0042 Image Processing, Information Engineering & Interdisciplinary Knowledge Exchange" }, "short": "CEEPUS-Netzwerk AT-0042", "url": null, "abstract": { "de": "Virtual Endoscopy of Airways: \r\nApplying methods of virtual reality to Spiral Computed Tomography investigations of airways, views can be generated similar to endoscopy . These views can be used to simulate endoscopic procedures for training of residents or for planing therapeutic interventions. Moreover, the virtual camera can be sent to positions, where a real endoscope fails.\r\n\r\nVirtual Dissection of the Colon: \r\nBesides endoscopy different imaging strategies are available for detection of colonic polyps. The medical goals is to detect those polyps as early as possible in order to prevent the development of a colonic cancer. Spiral Computed Tomography (S-CT) and Magnetic Resonance Tomography (MRT), augmented by virtual reality, have already demonstrated their effectivness in the detection of colonic polyps.\r\n\r\nComputer Aided Diagnosis of Breast Cancer:\r\nA system was programmed to support the reporting radiologist as a \"never tied second reader\" by using algorithms of artificial neural nets and image processing. In addition, a graphical user interface was developed to display the results of the \"never tired second reader\" to the radiologist in a convenient way. \r\n\r\n", "en": "Virtual Endoscopy of Airways: \r\nApplying methods of virtual reality to Spiral Computed Tomography investigations of airways, views can be generated similar to endoscopy . These views can be used to simulate endoscopic procedures for training of residents or for planing therapeutic interventions. Moreover, the virtual camera can be sent to positions, where a real endoscope fails.\r\n\r\nVirtual Dissection of the Colon: \r\nBesides endoscopy different imaging strategies are available for detection of colonic polyps. The medical goals is to detect those polyps as early as possible in order to prevent the development of a colonic cancer. Spiral Computed Tomography (S-CT) and Magnetic Resonance Tomography (MRT), augmented by virtual reality, have already demonstrated their effectivness in the detection of colonic polyps.\r\n\r\nComputer Aided Diagnosis of Breast Cancer:\r\nA system was programmed to support the reporting radiologist as a \"never tied second reader\" by using algorithms of artificial neural nets and image processing. In addition, a graphical user interface was developed to display the results of the \"never tired second reader\" to the radiologist in a convenient way. \r\n\r\n" }, "begin_planned": null, "begin_effective": "1997-01-01T01:00:00+01:00", "end_planned": null, "end_effective": "2050-12-31T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": null, "subprogram": null, "organization": 14106, "category": 10, "type": 10, "partner_function": 2, "manager": 51913, "contact": 51913, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "292-51913-10" ] }, { "id": 299, "title": { "de": "Chemotherapie von Phäochromocytomen: In vitro and in vivo Modelle als neue Testsysteme", "en": "Chemotherapie von Phäochromocytomen: In vitro and in vivo Modelle als neue Testsysteme" }, "short": "Chemotherapie von Phäochromocytomen", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": null, "begin_effective": "2004-08-01T02:00:00+02:00", "end_planned": null, "end_effective": "2007-08-31T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 81, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 52 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 27, "title": { "de": "Neue Mechanismen der selektiven Regulation von Basophilen", "en": "Neue Mechanismen der selektiven Regulation von Basophilen" }, "short": "Mechanismen der selektiven Regulation", "url": null, "abstract": { "de": "Allergie ist eine häufige Erkrankung, die in Form von Heuschnupfen, Bindehautentzündung, Asthma bronchiale und Hautveränderungen auftritt. Eine Gruppe von verwandten Erkrankungen, wie zum Beispiel intrinsisches Asthma oder Aspirin-Unverträglichkeit, imitiert sowohl klinisch als auch pathophysiologisch ein allergisches Geschehen, ohne dass dabei auslösende Allergene nachzuweisen sind. Die betroffenen Patienten leiden während ihres ganzen Lebens an diesen Symptomen, und eine kausale Therapie ist, außer in ausgewählten Fällen durch eine systemische Desensibilisierung mit dem jeweiligen Allergen, nicht möglich. Die symptomatische Therapie hingegen ist oft wenig wirksam oder, wie im Fall der Glucocorticoide, mit schweren Nebenwirkungen verbunden. Einem bisher weniger beachteten Subtypen der weissen Blutkörperchen, den basophilen Granulozyten, scheint eine zentrale Rolle zuzukommen, da sie sich nach Allergenkontakt im Entzündungsherd anreichern, Mediatoren der Allergie, wie zum Beispiel Histamin und Leukotrien C4, freisetzen, und große Mengen an Interleukin (IL)-4 und IL-13 produzieren. Das lässt vermuten, dass Basophile durch mehrere pathophysiologische Angriffspunkte an der Entstehung der Allergie, beziehungsweise des Asthma, beteiligt sind, einschließlich der allergischen Früh- und Spätreaktionen, Neigung zu Atemwegsverengung (Hyperreagibilität) und vermehrten IgE Produktion. Eine durch medikamentöse Maßnahmen gehemmte Einwanderung von Basophilen in die Entzündungsherde könnte somit die schädigende allergische Reaktionskaskade durch multiple Angriffspunkte durchbrechen.\r\nZur Zeit sind die pharmakologischen Grundlagen der selektiven Einwanderung von Basophilen wenig erforscht. Hierfür scheinen spezielle Mechanismen und Mediatoren verantwortlich zu sein, da die Kinetik der Infiltration durch Basophile von jenen der anderen Entzündungszellen unterscheidet. Das Ziel dieses Projektes ist die Erforschung neuer Mechanismen, deren sich Basophile während ihrer Einwanderung in das Gewebe bedienen. Durch die pharmakologische Charakterisierung dieser Mechanismen sollen Angriffspunkte für neue medikamentöse Therapien eröffnet werden: Erstens wollen wir aus Humanzellen neue, für Basophile spezifische chemotaktische Faktoren isolieren und charakterisieren. Zweitens untersuchen wir, ob das Zusammenspiel von verschiedenen Chemokinen eine spezifische Wirkung auf Basophile ausübt. Die Erkenntnisse aus diesen Experimenten werden neue, für die Entstehung und Perpetuierung von Allergie und Asthma relevante Mechanismen darlegen, deren medikamentöse Hemmung schlussendlich zu wirksameren Therapieformen führen wird. \r\n\r\n", "en": "Allergie ist eine häufige Erkrankung, die in Form von Heuschnupfen, Bindehautentzündung, Asthma bronchiale und Hautveränderungen auftritt. Eine Gruppe von verwandten Erkrankungen, wie zum Beispiel intrinsisches Asthma oder Aspirin-Unverträglichkeit, imitiert sowohl klinisch als auch pathophysiologisch ein allergisches Geschehen, ohne dass dabei auslösende Allergene nachzuweisen sind. Die betroffenen Patienten leiden während ihres ganzen Lebens an diesen Symptomen, und eine kausale Therapie ist, außer in ausgewählten Fällen durch eine systemische Desensibilisierung mit dem jeweiligen Allergen, nicht möglich. Die symptomatische Therapie hingegen ist oft wenig wirksam oder, wie im Fall der Glucocorticoide, mit schweren Nebenwirkungen verbunden. Einem bisher weniger beachteten Subtypen der weissen Blutkörperchen, den basophilen Granulozyten, scheint eine zentrale Rolle zuzukommen, da sie sich nach Allergenkontakt im Entzündungsherd anreichern, Mediatoren der Allergie, wie zum Beispiel Histamin und Leukotrien C4, freisetzen, und große Mengen an Interleukin (IL)-4 und IL-13 produzieren. Das lässt vermuten, dass Basophile durch mehrere pathophysiologische Angriffspunkte an der Entstehung der Allergie, beziehungsweise des Asthma, beteiligt sind, einschließlich der allergischen Früh- und Spätreaktionen, Neigung zu Atemwegsverengung (Hyperreagibilität) und vermehrten IgE Produktion. Eine durch medikamentöse Maßnahmen gehemmte Einwanderung von Basophilen in die Entzündungsherde könnte somit die schädigende allergische Reaktionskaskade durch multiple Angriffspunkte durchbrechen.\r\nZur Zeit sind die pharmakologischen Grundlagen der selektiven Einwanderung von Basophilen wenig erforscht. Hierfür scheinen spezielle Mechanismen und Mediatoren verantwortlich zu sein, da die Kinetik der Infiltration durch Basophile von jenen der anderen Entzündungszellen unterscheidet. Das Ziel dieses Projektes ist die Erforschung neuer Mechanismen, deren sich Basophile während ihrer Einwanderung in das Gewebe bedienen. Durch die pharmakologische Charakterisierung dieser Mechanismen sollen Angriffspunkte für neue medikamentöse Therapien eröffnet werden: Erstens wollen wir aus Humanzellen neue, für Basophile spezifische chemotaktische Faktoren isolieren und charakterisieren. Zweitens untersuchen wir, ob das Zusammenspiel von verschiedenen Chemokinen eine spezifische Wirkung auf Basophile ausübt. Die Erkenntnisse aus diesen Experimenten werden neue, für die Entstehung und Perpetuierung von Allergie und Asthma relevante Mechanismen darlegen, deren medikamentöse Hemmung schlussendlich zu wirksameren Therapieformen führen wird. \r\n\r\n" }, "begin_planned": null, "begin_effective": "2002-05-01T02:00:00+02:00", "end_planned": null, "end_effective": "2005-04-30T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 51756, "contact": 51756, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P15453", "ethics_committee": null, "edudract_number": null, "persons": [ "27-51756-10" ] }, { "id": 2314, "title": { "de": "Experimentelle Säuglingslungenfunktionsdiagnostik", "en": "Experimentelle Säuglingslungenfunktionsdiagnostik" }, "short": "P09518-MED", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": null, "begin_effective": "1994-04-01T02:00:00+02:00", "end_planned": null, "end_effective": "1996-07-31T02:00:00+02:00", "assignment": null, "program": null, "subprogram": null, "organization": 14095, "category": 10, "type": 10, "partner_function": 4, "manager": 51713, "contact": 51713, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2314-51713-10" ] }, { "id": 2797, "title": { "de": "Gemeinsame Anschaffung eines Hochleistungs-Transmissionselektronenmikroskopes (TEM) für die Core Facility Ultrastrukturanalyse und das Institut für Zellbiologie, Histologie und Embryologie", "en": "Gemeinsame Anschaffung eines Hochleistungs-Transmissionselektronenmikroskopes (TEM) für die Core Facility Ultrastrukturanalyse und das Institut für Zellbiologie, Histologie und Embryologie" }, "short": "EFRE-TEM", "url": null, "abstract": { "de": "An der Medizinischen Universität Graz wird ein neues Hochleistungs-Transmissionselektronenmikroskop beantragt. Aufbauend auf langjähriger Erfahrung in elektronenmikroskopischen Forschungsprojekten wird dieses Mikroskop die 3D-Untersuchung feinster Strukturen im Inneren von Zellen und Geweben und die genaue Lokalisation chemischer Elemente mit hoher Auflösung ermöglichen und so völlig neue Forschungsbereiche für die biomedizinischen Forschung in Graz eröffnen. Ein Kipphalter, ein Energiefilter, ein Röntgenemissionsdetektor und spezielle Software werden neue, unverzichtbare Technologien, Elektronentomographie und Analytische Elektronenmikroskopie, und damit eine Reihe neuer, innovativer Forschungsprojekte ermöglichen. \r\nDie Elektronentomographie dient zur Visualisierung feinster Strukturen im 3D - Bereich. Mittels Kipphalter werden dafür Präparate unter unterschiedlichen Blickwinkeln untersucht und spezielle bildverarbeitende Verfahren ermöglichen daraufhin eine 3D-Rekonstruktion. \r\nMit der Analytischen Elektronenmikroskopie kann man die chemischen Elemente in einem Schnittpräparat identifizieren und deren Verteilung in hoher Auflösung darstellen. Dieses Verfahren beruht darauf, dass jedes chemische Element auf eine charakteristische Weise mit dem Elektronenstrahl interagiert. Mittels Detektion dieser elementtypischen Interaktionen (Elektronenenergieverlustspektroskopie, EELS, und Energiedispersive Röntgenspektroskopie, EDX) können die chemischen Elemente innerhalb der Probe identifiziert werden. Mittels Energiefilter-Transmissionselektronenmikroskopie, EFTEM, kann die Verteilung der chemischen Elemente im Präparat dargestellt werden.\r\n\r\nBeispiele für Anwendungen dieser neuen Technologien sind im 3D-Bereich die Entstehung von Fetttröpfchen in Zellen oder die Gestalt und das Zusammenspiel von Molekülen, die an der synaptischen Übertragung an Kontaktstellen im Nervensystem beteiligt sind; Beispiele für Forschungsprojekte in der Analyse chemischer Elemente sind die Aufnahme und der Transport von Nanopartikeln im Körper (Teilbereich der Nanotechnologie), die Detektion medizinisch relevanter Einlagerungen von Schwermetallen in Geweben oder die Diagnostik neuroendokriner Erkrankungen.\r\n\r\n", "en": "An der Medizinischen Universität Graz wird ein neues Hochleistungs-Transmissionselektronenmikroskop beantragt. Aufbauend auf langjähriger Erfahrung in elektronenmikroskopischen Forschungsprojekten wird dieses Mikroskop die 3D-Untersuchung feinster Strukturen im Inneren von Zellen und Geweben und die genaue Lokalisation chemischer Elemente mit hoher Auflösung ermöglichen und so völlig neue Forschungsbereiche für die biomedizinischen Forschung in Graz eröffnen. Ein Kipphalter, ein Energiefilter, ein Röntgenemissionsdetektor und spezielle Software werden neue, unverzichtbare Technologien, Elektronentomographie und Analytische Elektronenmikroskopie, und damit eine Reihe neuer, innovativer Forschungsprojekte ermöglichen. \r\nDie Elektronentomographie dient zur Visualisierung feinster Strukturen im 3D - Bereich. Mittels Kipphalter werden dafür Präparate unter unterschiedlichen Blickwinkeln untersucht und spezielle bildverarbeitende Verfahren ermöglichen daraufhin eine 3D-Rekonstruktion. \r\nMit der Analytischen Elektronenmikroskopie kann man die chemischen Elemente in einem Schnittpräparat identifizieren und deren Verteilung in hoher Auflösung darstellen. Dieses Verfahren beruht darauf, dass jedes chemische Element auf eine charakteristische Weise mit dem Elektronenstrahl interagiert. Mittels Detektion dieser elementtypischen Interaktionen (Elektronenenergieverlustspektroskopie, EELS, und Energiedispersive Röntgenspektroskopie, EDX) können die chemischen Elemente innerhalb der Probe identifiziert werden. Mittels Energiefilter-Transmissionselektronenmikroskopie, EFTEM, kann die Verteilung der chemischen Elemente im Präparat dargestellt werden.\r\n\r\nBeispiele für Anwendungen dieser neuen Technologien sind im 3D-Bereich die Entstehung von Fetttröpfchen in Zellen oder die Gestalt und das Zusammenspiel von Molekülen, die an der synaptischen Übertragung an Kontaktstellen im Nervensystem beteiligt sind; Beispiele für Forschungsprojekte in der Analyse chemischer Elemente sind die Aufnahme und der Transport von Nanopartikeln im Körper (Teilbereich der Nanotechnologie), die Detektion medizinisch relevanter Einlagerungen von Schwermetallen in Geweben oder die Diagnostik neuroendokriner Erkrankungen.\r\n\r\n" }, "begin_planned": null, "begin_effective": "2009-06-10T02:00:00+02:00", "end_planned": null, "end_effective": "2011-05-31T02:00:00+02:00", "assignment": null, "program": null, "subprogram": null, "organization": 25164, "category": 10, "type": 10, "partner_function": 4, "manager": 50960, "contact": 50960, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10, 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2797-50960-10" ] }, { "id": 199, "title": { "de": "CLINICIP: Closed Loop Insulin Infusion for Critically Ill Patients", "en": "CLINICIP: Closed Loop Insulin Infusion for Critically Ill Patients" }, "short": "CLINICIP", "url": null, "abstract": { "de": "Im Projekt Clinicip wird ein intelligentes System für eine verbesserte Überwachung und Behandlung von kritisch kranken Menschen, die sich auf Intensivstationen befinden, entwickelt. Durch Bio-sensoren werden die Blutzuckerwerte und andere Stoffwechselparameter kontinuierlich gemessen. In einer frühen Projektphase soll damit ein anpassungsfähiger Kontrollalgorithmus eine beratende Funktion für das Krankenhauspersonal ausüben; d.h. dieses System soll als Entscheidungshilfe für Ärzte und Krankenschwestern zum Einsatz kommen. In weiterer Folge wird aufgrund der aktuellen Messergebnisse des Blutzuckerspiegels und der anderen Stoffwechselparameter automatisch die richtige Menge Insulin verabreicht und damit der Stoffwechsel dieser schwer erkrankten Menschen optimiert. ", "en": "Im Projekt Clinicip wird ein intelligentes System für eine verbesserte Überwachung und Behandlung von kritisch kranken Menschen, die sich auf Intensivstationen befinden, entwickelt. Durch Bio-sensoren werden die Blutzuckerwerte und andere Stoffwechselparameter kontinuierlich gemessen. In einer frühen Projektphase soll damit ein anpassungsfähiger Kontrollalgorithmus eine beratende Funktion für das Krankenhauspersonal ausüben; d.h. dieses System soll als Entscheidungshilfe für Ärzte und Krankenschwestern zum Einsatz kommen. In weiterer Folge wird aufgrund der aktuellen Messergebnisse des Blutzuckerspiegels und der anderen Stoffwechselparameter automatisch die richtige Menge Insulin verabreicht und damit der Stoffwechsel dieser schwer erkrankten Menschen optimiert" }, "begin_planned": null, "begin_effective": "2004-01-01T01:00:00+01:00", "end_planned": null, "end_effective": "2007-12-31T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 21, "subprogram": null, "organization": 14046, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": 51831, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "199-51831-10" ] }, { "id": 2315, "title": { "de": "The genetic background of bronchial asthma and allergy", "en": "The genetic background of bronchial asthma and allergy" }, "short": "J01055-MED", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": null, "begin_effective": "1995-08-01T02:00:00+02:00", "end_planned": null, "end_effective": "1996-07-21T02:00:00+02:00", "assignment": null, "program": null, "subprogram": null, "organization": 14095, "category": 10, "type": 10, "partner_function": 4, "manager": 51713, "contact": 51713, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2315-51713-10" ] }, { "id": 332, "title": { "de": "Investigation of the Effect of Physiological Hyperinsulinemia on the Access of Macromolecules to Insulin Sensitive Tissues", "en": "Investigation of the Effect of Physiological Hyperinsulinemia on the Access of Macromolecules to Insulin Sensitive Tissues" }, "short": "Access to Insulin-Sensitive Tissues", "url": null, "abstract": { "de": "In recent years a rapid growing body of work has demonstrated that insulin, besides its metabolic effects, also stimulates systemic blood flow and tissue perfusion to enhance the delivery of nutrients to insulin sensitive tissues. It has benn suggested that these effects of insulin might support insulins primary mechanism at the cellular level to stimulate glucose disposal. The objective of the present grant application is to evaluate the effects of physiological hyperinsulinemia on the perfusion of insulin sensitive tissues by direct measurement of the distribution kinetics of the extracellular marker inulin in interstitial fluid of healthy volunteers. Results from the proposed study will add new knowledge about the potential of insulin to stimulate glucose uptake and other metabolic processes via hemodynamic as opposed to purely biochemical processes. The submitted project is a prerequisite for further planned studies investigating the hemodynamic effect of insulin during disease states such as obesity and type II diabetes.", "en": "In recent years a rapid growing body of work has demonstrated that insulin, besides its metabolic effects, also stimulates systemic blood flow and tissue perfusion to enhance the delivery of nutrients to insulin sensitive tissues. It has benn suggested that these effects of insulin might support insulins primary mechanism at the cellular level to stimulate glucose disposal. The objective of the present grant application is to evaluate the effects of physiological hyperinsulinemia on the perfusion of insulin sensitive tissues by direct measurement of the distribution kinetics of the extracellular marker inulin in interstitial fluid of healthy volunteers. Results from the proposed study will add new knowledge about the potential of insulin to stimulate glucose uptake and other metabolic processes via hemodynamic as opposed to purely biochemical processes. The submitted project is a prerequisite for further planned studies investigating the hemodynamic effect of insulin during disease states such as obesity and type II diabetes." }, "begin_planned": null, "begin_effective": "2005-03-01T01:00:00+01:00", "end_planned": null, "end_effective": "2006-10-31T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": null, "subprogram": null, "organization": 14046, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 151 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2540, "title": { "de": "Modellierung des kardiopulmonal-arteriellen Baroreflexes ", "en": "Modellierung des kardiopulmonal-arteriellen Baroreflexes " }, "short": "Baroreflex", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": null, "begin_effective": "2006-02-15T01:00:00+01:00", "end_planned": null, "end_effective": "2009-03-14T01:00:00+01:00", "assignment": null, "program": 72, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 439, "title": { "de": "Möglichkeiten der pharmakologischen und nicht-pharmakologischen Beeinflussung lokaler Knochenumbauprozesse vor, während und nach kieferorthopädischen Behandlungen zur Optimierung von Therapiedauer und Nachhaltigkeit des Regulierungsergebnisses", "en": "Möglichkeiten der pharmakologischen und nicht-pharmakologischen Beeinflussung lokaler Knochenumbauprozesse vor, während und nach kieferorthopädischen Behandlungen zur Optimierung von Therapiedauer und Nachhaltigkeit des Regulierungsergebnisses" }, "short": "Lokale Knochenumbauprozesse", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": null, "begin_effective": "2005-01-01T01:00:00+01:00", "end_planned": null, "end_effective": "2007-12-31T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51874, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "439-51874-10" ] }, { "id": 708, "title": { "de": "Physiology and Pathophysiology of Excitability and Contractility in the isolated Cell", "en": "Physiology and Pathophysiology of Excitability and Contractility in the isolated Cell" }, "short": "SFB007/707 Biomembranen", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": null, "begin_effective": "1995-10-01T01:00:00+01:00", "end_planned": null, "end_effective": "2001-09-30T02:00:00+02:00", "assignment": null, "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 51681, "contact": 51681, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P11131", "ethics_committee": null, "edudract_number": null, "persons": [ "708-51681-10" ] }, { "id": 437, "title": { "de": "Am Übergang vom Feten zum Neugeborenen: Neonatale Immunologie.", "en": "At the crossing-point from fetus to newborn: neonatal immunology." }, "short": "Neonatal immunology", "url": null, "abstract": { "de": "During pregnancy TH1 immunity is downregulated favouring a TH2 driven immunresponse so that preeclampsia, premature delivery or even placental detachment and fetal soll are preventet. Furthermore, B cells express primarily IgM, but have not completed their maturation process in order to perform Ig switching. In addition to that, reduction in the available bone marrow reserve of granulocyte precursors, recuction in serum complement activity and deficient phagocytic cell function contribute to a physiologically immaturity of the neonate's immune system. An adult form of immune response is developed after live birth during the first yeaars of childhood by interaction with environmental stimuli (antigens). The reduced ability of the neonat's immune system to respond to bacterial, viral or fungal organisms is reflected by a higher rate of infections and septic events. The incidence of neonatal sepsis is still high, it varies from 1 to 8, 1 casses per 1.000 live births. The factor associated most significantly with development of septicaemia is low birth weight, therefore, preterm infants are essentially higher risk. Inflaamation and sepsis do not only contribute to a high mortality rate, but also to high morbidity. For example, neurological outcome, expecially occurrence of cerebral palsy, is strongly associated with neionatal infection. In order to reuce the resulting high mortality and morbidity, but also in order to study a model of primary immune response diverse studies have been performed by using umbilical cord blood. However, few investigations have been made with peripheral blood mononuclear cells of neonates, especially of lower gestational age. Peripheral blood represents another environment; so blood cells are exposed to other stimuli, resulting in other messages for B and T cells triggering activation and subsequent proliferation, differentntiation or even cell-death. Therefore, we want to examine absolute count of diverse lymphcyte subsets for different gestational ages in order to get reliable reference values, expression patterns of costimulatory molecules like CD40/CD40L, CD80, CD86, CD28, CD152, Interleukinsecretion of T cells, functional abilities conerning activation, proliferation and cell-death as read-out systems for activation and interactions of B and T cells immediately after life-birth.", "en": "During pregnancy TH1 immunity is downregulated favouring a TH2 driven immunresponse so that preeclampsia, premature delivery or even placental detachment and fetal soll are preventet. Furthermore, B cells express primarily IgM, but have not completed their maturation process in order to perform Ig switching. In addition to that, reduction in the available bone marrow reserve of granulocyte precursors, recuction in serum complement activity and deficient phagocytic cell function contribute to a physiologically immaturity of the neonate's immune system. An adult form of immune response is developed after live birth during the first yeaars of childhood by interaction with environmental stimuli (antigens). The reduced ability of the neonat's immune system to respond to bacterial, viral or fungal organisms is reflected by a higher rate of infections and septic events. The incidence of neonatal sepsis is still high, it varies from 1 to 8, 1 casses per 1.000 live births. The factor associated most significantly with development of septicaemia is low birth weight, therefore, preterm infants are essentially higher risk. Inflaamation and sepsis do not only contribute to a high mortality rate, but also to high morbidity. For example, neurological outcome, expecially occurrence of cerebral palsy, is strongly associated with neionatal infection. In order to reuce the resulting high mortality and morbidity, but also in order to study a model of primary immune response diverse studies have been performed by using umbilical cord blood. However, few investigations have been made with peripheral blood mononuclear cells of neonates, especially of lower gestational age. Peripheral blood represents another environment; so blood cells are exposed to other stimuli, resulting in other messages for B and T cells triggering activation and subsequent proliferation, differentntiation or even cell-death. Therefore, we want to examine absolute count of diverse lymphcyte subsets for different gestational ages in order to get reliable reference values, expression patterns of costimulatory molecules like CD40/CD40L, CD80, CD86, CD28, CD152, Interleukinsecretion of T cells, functional abilities conerning activation, proliferation and cell-death as read-out systems for activation and interactions of B and T cells immediately after life-birth." }, "begin_planned": null, "begin_effective": "2005-03-01T01:00:00+01:00", "end_planned": null, "end_effective": "2008-02-28T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 79, "subprogram": null, "organization": 14048, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "437-51743-12", "437-51643-11" ] }, { "id": 28, "title": { "de": "Rolle von Stem Cell Factor in der Regulation von Basophilen.", "en": "Rolle von Stem Cell Factor in der Regulation von Basophilen." }, "short": "Stem Cell Factor - Basophile", "url": null, "abstract": { "de": "Rolle von Stem Cell Factor in der Regulation von Basophilen.", "en": "Rolle von Stem Cell Factor in der Regulation von Basophilen." }, "begin_planned": null, "begin_effective": "2003-01-01T01:00:00+01:00", "end_planned": null, "end_effective": "2004-06-30T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 79, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 51756, "contact": 51756, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "28-51756-10" ] }, { "id": 333, "title": { "de": "Psycho-Neuro-Immunologie. Einfluss einer psychosozialen Intervention auf T und NK Zellfunktion von Patientinnen mit Mammakarzinom", "en": "Psycho-Neuro-Immunologie. Einfluss einer psychosozialen Intervention auf T und NK Zellfunktion von Patientinnen mit Mammakarzinom" }, "short": "Psycho-Neuro-Immunologie Mammakarzinom", "url": null, "abstract": { "de": "The autonomic, neuroendocrine, and the immune systems are orchestrated in part to preserve conditions compatible with life. The critical question in immunosurveillance against cancer is whether differences between individuals with regard to immunologic host-defense mechanisms can predict the incidende or progression of cancer. Acute as well as chronic stressors have been associated with reduction of various in vitro measures of immune function. Even acute commonplace stressful events like a final examination scenario for medical students or \"the public speaking situation\" are associated with transient changes in immunologic parameters (e.g. natural killer(NK) cell number and cytotoxity, T helper/inducer cell number, production of interferon (IFN) gamma by lymphocytes stimulated with Concavalin-A, etc.) along with elevated stress hormone levels and cardiovascular activation compared to controls. The aims of the study are: * Further evaluation of differences in immune parameters of patients with breast cancer compared to their significant others and non related healthy volunteers focusing on differences in the relative number of T and NK cell subpopulations, onset of apoptosis and functional parameters like the kinetics of perforin release of stimulated T and NK cells. *Assessment of hormonal parameters in the three study populations and their correlation to immune parameters as well as psychosocial parameters. * Investigation of the influence of psychosocial intervention on the immune system with special regard to T cell- and NK cell subpopulations, rate of apoptosis and perforin release of these immune cells in patients with operated breast cancer compared to significant others and healthy volunteers.", "en": "The autonomic, neuroendocrine, and the immune systems are orchestrated in part to preserve conditions compatible with life. The critical question in immunosurveillance against cancer is whether differences between individuals with regard to immunologic host-defense mechanisms can predict the incidende or progression of cancer. Acute as well as chronic stressors have been associated with reduction of various in vitro measures of immune function. Even acute commonplace stressful events like a final examination scenario for medical students or \"the public speaking situation\" are associated with transient changes in immunologic parameters (e.g. natural killer(NK) cell number and cytotoxity, T helper/inducer cell number, production of interferon (IFN) gamma by lymphocytes stimulated with Concavalin-A, etc.) along with elevated stress hormone levels and cardiovascular activation compared to controls. The aims of the study are: * Further evaluation of differences in immune parameters of patients with breast cancer compared to their significant others and non related healthy volunteers focusing on differences in the relative number of T and NK cell subpopulations, onset of apoptosis and functional parameters like the kinetics of perforin release of stimulated T and NK cells. * Assessment of hormonal parameters in the three study populations and their correlation to immune parameters as well as psychosocial parameters. * Investigation of the influence of psychosocial intervention on the immune system with special regard to T cell- and NK cell subpopulations, rate of apoptosis and perforin release of these immune cells in patients with operated breast cancer compared to significant others and healthy volunteers" }, "begin_planned": null, "begin_effective": "2005-01-01T01:00:00+01:00", "end_planned": null, "end_effective": "2006-10-31T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 79, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 51692, "contact": 51692, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "333-50563-12", "333-51692-10", "333-52003-12" ] } ] }