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GET /v1/research/project/?format=api&offset=2240
{ "count": 2260, "next": null, "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=2220", "results": [ { "id": 2034, "title": { "de": "Analyse von Zytokin-Genpolymorphismen bei Patienten mit retinalem nichtentzündlichen Arterienverschluss", "en": "Analyse von Zytokin-Genpolymorphismen bei Patienten mit retinalem nichtentzündlichen Arterienverschluss" }, "short": "ZYTOKIN_GENPOLYMORPHISMEN_ARTERIEN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-06-01T02:00:00+02:00", "begin_effective": "2009-06-01T02:00:00+02:00", "end_planned": "2009-12-31T01:00:00+01:00", "end_effective": "2009-12-31T01:00:00+01:00", "assignment": "2010-01-12T18:03:24+01:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": 51984, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 938 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2034-51984-10" ] }, { "id": 2381, "title": { "de": "EUTRAF - THE EUROPEAN NETWORK FOR TRANSLATIONAL RESEARCH IN ATRIAL FIBRILLATION", "en": "EUTRAF - THE EUROPEAN NETWORK FOR TRANSLATIONAL RESEARCH IN ATRIAL FIBRILLATION" }, "short": "EUTRAF", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2015-12-31T01:00:00+01:00", "end_effective": "2015-10-31T01:00:00+01:00", "assignment": "2011-01-19T10:52:22+01:00", "program": 24, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 2, "manager": 50168, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "261057", "ethics_committee": null, "edudract_number": null, "persons": [ "2381-60041-12", "2381-66430-12", "2381-79173-12", "2381-50168-10" ] }, { "id": 2203, "title": { "de": "Effekt der Hyperthermie auf die Zytokinproduktion", "en": "Effect of Fever-Range Whole Body Hyperthermia induced by water-filtered infrared A expusure on circulating cytokine levels in healthy volunteers" }, "short": "Hyperthermie ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-06-01T02:00:00+02:00", "begin_effective": "2009-06-01T02:00:00+02:00", "end_planned": "2010-06-01T02:00:00+02:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2010-05-14T11:55:05+02:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5775, "title": { "de": "Die Rolle von PEPCK-M in der zellulären Anpassung von Lungenkrebszellen", "en": "The role of PEPCK-M in the cellular adaptation of lung cancer cells" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-06-01T02:00:00+02:00", "begin_effective": "2019-06-01T02:00:00+02:00", "end_planned": "2021-11-30T01:00:00+01:00", "end_effective": "2021-05-31T02:00:00+02:00", "assignment": "2019-04-24T15:18:16+02:00", "program": 116, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2672, "title": { "de": "2.1 Metabolic biomarkers for progression of fatty liver disease and chronic viral hepatitis", "en": "2.1 Metabolic biomarkers for progression of fatty liver disease and chronic viral hepatitis" }, "short": "BioPersMed Project No 2.1", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-01T02:00:00+02:00", "begin_effective": "2010-07-01T02:00:00+02:00", "end_planned": "2015-06-30T02:00:00+02:00", "end_effective": "2015-06-30T02:00:00+02:00", "assignment": "2010-12-12T12:15:40+01:00", "program": 94, "subprogram": "K-Projekt", "organization": 14081, "category": 10, "type": 10, "partner_function": 3, "manager": 51530, "contact": 51530, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2, 1040, 1154 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2672-81601-12", "2672-88572-12", "2672-51530-10" ] }, { "id": 2673, "title": { "de": "2.3 Vitamin D metabolites as novel biomarkers for progression and prognosis in liver disease", "en": "2.3 Vitamin D metabolites as novel biomarkers for progression and prognosis in liver disease" }, "short": "BioPersMed Project No. 2.3", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-01T02:00:00+02:00", "begin_effective": "2010-07-01T02:00:00+02:00", "end_planned": "2015-06-30T02:00:00+02:00", "end_effective": "2015-06-30T02:00:00+02:00", "assignment": "2010-12-12T12:15:40+01:00", "program": 94, "subprogram": "K-Projekt", "organization": 14081, "category": 10, "type": 10, "partner_function": 3, "manager": 51530, "contact": 51530, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2, 1040, 1154 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2673-51530-10" ] }, { "id": 6847, "title": { "de": "Neurofilament-Leichtketten als Biomarker bei Patient*innen mit Autosomal dominanter\r\nOptikusatrophie und Leberscher hereditärer Optikusneuropathie", "en": "Neurofilament light chain as biomarker in patients with Autosomal Dominant Optic Atrophy and Leber Hereditary Optic Neuropathy" }, "short": "Biomarker bei ADOA und LHON", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-09-28T02:00:00+02:00", "begin_effective": "2021-09-28T02:00:00+02:00", "end_planned": "2023-03-28T02:00:00+02:00", "end_effective": "2023-03-28T02:00:00+02:00", "assignment": "2021-12-17T14:17:06+01:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": 97142, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2194 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6847-97142-10" ] }, { "id": 7773, "title": { "de": "Entwicklung einer App zur Bewertung sowie Quantifizierung des Schweregrads idiopathischer epiretinaler Membranen und Vorschlag eines Punktesystems zur weiteren Therapiegliederung: eine prospektive Pilotstudie ", "en": "Developing an App to assess and quantify idiopathic epiretinal membrane severity and proposing a scoring system for further treatment recommendation: a prospective pilot study" }, "short": "ERM APP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-10-10T02:00:00+02:00", "begin_effective": "2023-10-01T02:00:00+02:00", "end_planned": "2024-10-10T02:00:00+02:00", "end_effective": "2024-09-30T02:00:00+02:00", "assignment": "2023-09-19T12:46:56+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": 104906, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 938, 2194 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7773-104906-10" ] }, { "id": 8356, "title": { "de": "CXCR4 role in the anabolic response of teriparatide in bone ", "en": "CXCR4 role in the anabolic response of teriparatide in bone " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2028-03-31T02:00:00+02:00", "end_effective": "2028-03-31T02:00:00+02:00", "assignment": "2024-08-19T14:37:04+02:00", "program": 72, "subprogram": null, "organization": 14028, "category": 10, "type": 10, "partner_function": 4, "manager": 107134, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT4629323", "ethics_committee": null, "edudract_number": null, "persons": [ "8356-50464-12", "8356-56571-12", "8356-107134-10", "8356-110967-12", "8356-129458-12", "8356-122433-12", "8356-124131-12" ] }, { "id": 6881, "title": { "de": "Biomarker für kardiovaskuläre Risiken und neurodegenerative Erkrankungen nach insulininduzierter Hypoglykämie", "en": "Biomarkers for cardiovascular risk and neurodegenerative disease following insulin-induced hypoglycaemia" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-12-01T01:00:00+01:00", "begin_effective": "2021-12-01T01:00:00+01:00", "end_planned": "2022-06-30T02:00:00+02:00", "end_effective": "2022-06-30T02:00:00+02:00", "assignment": "2022-01-17T15:13:04+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 1, "manager": 100944, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 151 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6881-78894-11", "6881-100944-10" ] }, { "id": 2197, "title": { "de": "Aufbau eines osteuropäisches Implantationszentrum mit angeschlossenen Rehabilitations- und Trainingszentrum", "en": "Development of an Eastern European implantation center with adjacent Rehabilitation and Trainings center" }, "short": "Osteuropäisches_Implantationszentrum", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-04-01T02:00:00+02:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2011-02-01T01:00:00+01:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2010-05-07T10:52:01+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2335, "title": { "de": "Steirische Vitamin D Bluthochdruck Studie", "en": "Styrian Vitamin D Hypertension Study" }, "short": "STEIRISCHE_BLUTHOCHDRUCK_STUDIE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-08-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2013-07-31T02:00:00+02:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2010-11-10T10:05:48+01:00", "program": 79, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 53344, "contact": 53344, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2335-53344-10" ] }, { "id": 2028, "title": { "de": "Characterization of breast cancer stem cells and their responsiveness to osteoporose treatment", "en": "Characterization of breast cancer stem cells and their responsiveness to osteoporose treatment" }, "short": "BREAST CANCER STEM CELLS_OSTEO_TREAT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-02-01T01:00:00+01:00", "begin_effective": "2010-02-01T01:00:00+01:00", "end_planned": "2012-01-31T01:00:00+01:00", "end_effective": "2012-07-31T02:00:00+02:00", "assignment": "2009-12-22T15:26:56+01:00", "program": 79, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 51063, "contact": 51063, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2028-51063-10" ] }, { "id": 2090, "title": { "de": "Expression profiling in hypoxic non-small cell lung cancer", "en": "Expression profiling in hypoxic non-small cell lung cancer" }, "short": "NON-SMALL CELL LUNG CANCER ", "url": null, "abstract": { "de": "Das Bronchialkarzinom ist nach wie vor die führende Krebstodesursache weltweit. 80% sind sogenannte Nicht-kleinzellige Bronchialkarzinome (non-small cell lung cancers, NSCLC). Das Gesamtüberleben der Patienten mit NSCLC ist schlecht, trotz der derzeit vorhandenen Therapieoptionen, zum Teil wegen Resistenz gegenüber Radio- und Chemotherapie. Tumorhypoxie (verminderte Sauerstoffzufuhr im Tumor) induziert in den Tumorzellen Adaptationsvorgänge und ist zum Teil für die Therapieresistenz verantwortlich. Die genauen Mechanismen sind jedoch nicht bekannt. Unser neu etabliertes ex-vivo Modell der hypoxischen Adaptation beim NSCLC, welches auf der Verwendung von kleinsten NSCLC Fragmenten aus Operationsmaterial beruht, ist geignet, um die Vorgänge im Tumor unter hypoxischen Bedingungen zu untersuchen. Das Ziel der vorliegenden Studie ist, die Genexpressionsmuster der in Hypoxie bzw unter normalen Sauerstoffbedingungen kultivierten NSCLC Fragmente zu vergleichen. Die differenziell regulierten Gene werden dafür mittels cDNA microarrays bestimmt. Die Ergebnisse werden in nachfolgenden Einzelgen-Polymerase Kettenreaktionen validiert. Unsere Studie könnte somit das Verständnis der Pathomechanismen beim Tumorwachstum verbessern und mögliche neue Therapieoptionen beim NSCLC aufzeigen.", "en": "Lung cancer is the leading cause of cancer deaths overall in the world. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancers. Overall survival is poor, in part due to resistance to chemotherapy and radiotherapy. Intratumoral hypoxia (limited oxygen supply) frequently occurs in solid tumors, such as NSCLC. Hypoxia initiates adaptive responses in tumor cells and was shown to induce chemotherapy resistance and promote aggressive tumor growth. The mechanisms of hypoxia-induced adaptive responses in solid tumors are not fully elucidated, yet. We established an ex-vivo model for hypoxic adaptation using NSCLC surgery fragments. The fragments are maintained in short-time culture in hypoxia or ambient oxygen (normoxia) without significant loss of viability or increase in apoptosis and display significant induction of carbonic anhydrase IX, a marker for tumor hypoxia, under hypoxic conditions. The aim of the current study is to analyze hypoxia-induced gene expression changes using cDNA microarrays and consecutive single gene real-time polymerase chain reaction (RT-PCR) on hypoxic vs. normoxic NSCLC fragments, in order to identify genes that are consistently induced or suppressed in hypoxia. Our study thus provides a novel approach to identify molecular pathways that are crucial for hypoxic adaptive changes in NSCLC and might represent targets for therapy." }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-02-09T11:39:13+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 57557, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2090-57557-10" ] }, { "id": 1880, "title": { "de": "Untersuchung von Keimbahnpolymorphismen im VEGF-Pathway um Metastasierung bei Patientinnen mit Brustkrebs voherzusagen", "en": "Untersuchung von Keimbahnpolymorphismen im VEGF-Pathway um Metastasierung bei Patientinnen mit Brustkrebs voherzusagen" }, "short": "KEIMBAHNPOLYMORPH", "url": null, "abstract": { "de": "Brustkrebs ist das häufigste Karzinom bei Frauen und die zweithäufigste Ursache für Karzinom-bezogenen Tod in Europa mit einem Lebenszeitrisiko von 10-13%. Metastasierung zeigt sich für ca. 90% der Krazinom-bezogenen Todesfälle mit weiter steigendem Einfluss verantwortlich. Metastasierung umfasst einen komplexen Prozess bei dem die Neubildung von Gefäßen (Angiogenese) eine Schlüsselrolle spielt. Der vaskuläre endotheliale Wachstumsfaktor (VEGF) ist mit seinen Rezeptoren (VEGFR) der wichtigste Aktivator. im VEGF/VEGFR findet man substantielle genetische Variabilität inklusive multipler Einzelnukleotid-Polymorphismen (SNPs). DNA-Sequenz Variationen in den VEGF/VEGFR-Genen verändern die VEGF-Produktion und/oder Aktivität un verursachen inter-individuelle Unterschiede bei Angiogenese und Tumorwachstum. Im Rahmen dieses Projektes untersuchen wir SNPs in den VEGF/VEGFR Genen bei 800 Patientinnen mit Brustkrebs und korrelieren diese mit dem erkrankungsfreien Überleben. \r\nAls Hauptziel unserer Studie möchten wir somit genetische Vorhersagevariablen für Brustkrebs-Metastasierung entwickeln. Unsere Resultate könnten zu einer optimierten Risikoabschätzung bei Patientinnen mit Brustkrebs und somit zu einer individualisierten Therapieplanung führen.", "en": "Brustkrebs ist das häufigste Karzinom bei Frauen und die zweithäufigste Ursache für Karzinom-bezogenen Tod in Europa mit einem Lebenszeitrisiko von 10-13%. Metastasierung zeigt sich für ca. 90% der Krazinom-bezogenen Todesfälle mit weiter steigendem Einfluss verantwortlich. Metastasierung umfasst einen komplexen Prozess bei dem die Neubildung von Gefäßen (Angiogenese) eine Schlüsselrolle spielt. Der vaskuläre endotheliale Wachstumsfaktor (VEGF) ist mit seinen Rezeptoren (VEGFR) der wichtigste Aktivator. im VEGF/VEGFR findet man substantielle genetische Variabilität inklusive multipler Einzelnukleotid-Polymorphismen (SNPs). DNA-Sequenz Variationen in den VEGF/VEGFR-Genen verändern die VEGF-Produktion und/oder Aktivität un verursachen inter-individuelle Unterschiede bei Angiogenese und Tumorwachstum. Im Rahmen dieses Projektes untersuchen wir SNPs in den VEGF/VEGFR Genen bei 800 Patientinnen mit Brustkrebs und korrelieren diese mit dem erkrankungsfreien Überleben. \r\nAls Hauptziel unserer Studie möchten wir somit genetische Vorhersagevariablen für Brustkrebs-Metastasierung entwickeln. Unsere Resultate könnten zu einer optimierten Risikoabschätzung bei Patientinnen mit Brustkrebs und somit zu einer individualisierten Therapieplanung führen." }, "begin_planned": "2009-07-01T02:00:00+02:00", "begin_effective": "2009-07-01T02:00:00+02:00", "end_planned": "2009-12-31T01:00:00+01:00", "end_effective": "2009-12-31T01:00:00+01:00", "assignment": "2009-07-31T14:09:06+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 58814, "contact": 58814, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1880-58814-10" ] }, { "id": 1882, "title": { "de": "Analysis of drug-metabolizing enzyme polymorphisms for response to anthracycline-based neoadjuvant chemotherapy in breast cancer", "en": "Analysis of drug-metabolizing enzyme polymorphisms for response to anthracycline-based neoadjuvant chemotherapy in breast cancer" }, "short": "CHEMOTHERAP_BREAST CANCER", "url": null, "abstract": { "de": "Breast cancer is the most common malignancy affecting women. It is the second leading cause of cancer-related death in Europe and the United States. Despite several improvements in early diagnosis, surgical techniques and hormone-, immune- and chemotherapy, this disease remains a threat to life for a large number of women. Moreover, providing individual treatment with low toxicity but maximum benefit is still an unsolved problem.\r\nNeoadjuvant chemotherapy using anthracycline-containing regimes is a standard therapy for patients with locally advanced breast cancer and is increasingly used for early-stage operable disease. The main goal of neoadjuvant chemotherapy is to eliminate potential micrometastasis, thus improving disease-free survial.\r\nPharmacogenetics is aimed at understanding and predicting an individual's drug response based upon genetic variation.\r\n\r\nIn this pharmacogenetic project we investigate a set of heritable genetic factors in drug-metabolizing enzymes that might predict drug-induced anti-tumor response and toxicity of anthracycline-based neoadjuvant therapy in breast cancer, based upon multigenetic analysis.", "en": "Breast cancer is the most common malignancy affecting women. It is the second leading cause of cancer-related death in Europe and the United States. Despite several improvements in early diagnosis, surgical techniques and hormone-, immune- and chemotherapy, this disease remains a threat to life for a large number of women. Moreover, providing individual treatment with low toxicity but maximum benefit is still an unsolved problem.\r\nNeoadjuvant chemotherapy using anthracycline-containing regimes is a standard therapy for patients with locally advanced breast cancer and is increasingly used for early-stage operable disease. The main goal of neoadjuvant chemotherapy is to eliminate potential micrometastasis, thus improving disease-free survial.\r\nPharmacogenetics is aimed at understanding and predicting an individual's drug response based upon genetic variation.\r\n\r\nIn this pharmacogenetic project we investigate a set of heritable genetic factors in drug-metabolizing enzymes that might predict drug-induced anti-tumor response and toxicity of anthracycline-based neoadjuvant therapy in breast cancer, based upon multigenetic analysis." }, "begin_planned": "2009-05-01T02:00:00+02:00", "begin_effective": "2009-05-01T02:00:00+02:00", "end_planned": "2009-09-30T02:00:00+02:00", "end_effective": "2010-09-30T02:00:00+02:00", "assignment": "2009-08-03T14:52:33+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 58814, "contact": 58814, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1882-58814-10" ] }, { "id": 2474, "title": { "de": "Angiogenesis gene polymorphisms and efficacy of bevacizumab therapy in patients with metastatic colorectal cancer", "en": "Angiogenesis gene polymorphisms and efficacy of bevacizumab therapy in patients with metastatic colorectal cancer" }, "short": "ANGIOGENESIS_GENE_POLYMORPH_ÖGHO", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-04-01T02:00:00+02:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2011-04-30T02:00:00+02:00", "end_effective": "2011-04-30T02:00:00+02:00", "assignment": "2011-05-13T13:36:41+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 58814, "contact": 58814, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 122 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2474-58814-10" ] }, { "id": 2152, "title": { "de": "Variation des Erythropoetin-Gens als Risikofaktor für Brustkrebs", "en": "Variation des Erythropoetin-Gens als Risikofaktor für Brustkrebs" }, "short": "ERYTHROPOETIN_BRUSTKREBS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2010-12-31T01:00:00+01:00", "end_effective": "2011-06-30T02:00:00+02:00", "assignment": "2010-03-04T14:48:32+01:00", "program": 81, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 58814, "contact": 58814, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 52 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2152-58814-10" ] }, { "id": 8766, "title": { "de": "Wirksamkeit eines Therapieoptimierungsmodules zu Verbesserung der ärztlichen Leitlinienadhärenz bei medikamnetöser Therapie für PatientInnen mit Herzinsuffizienz-\"AMPEL\" trial", "en": "Efficacy of an Assisted therapy optimizing Module to impove Physician adherence with guideline-directed medical therapy in patients with heart failure - \"AMPEL\" trial" }, "short": "AMPEL", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": null, "begin_effective": "2025-04-01T02:00:00+02:00", "end_planned": null, "end_effective": "2027-03-31T02:00:00+02:00", "assignment": "2025-04-11T13:25:54+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 1, "manager": 72301, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": 2, "language": null, "funders": [ 2160 ], "funder_projectcode": null, "ethics_committee": "1110/2024", "edudract_number": null, "persons": [ "8766-72301-10" ] }, { "id": 744, "title": { "de": "Expression von Apoptose-regulierenden Faktoren beim nicht-kleinzelligen Bronchialkarzinom (NSCLC): Korrelation mit dem Ansprechen auf Chemotherapie.", "en": "Expression von Apoptose-regulierenden Faktoren beim nicht-kleinzelligen Bronchialkarzinom (NSCLC): Korrelation mit dem Ansprechen auf Chemotherapie." }, "short": "Apoptose-regulierende Faktoren ", "url": null, "abstract": { "de": "Das Bronchialkarzinom zählt zu den häufigsten malignen Erkrankungen. Die Prognose bei fortgeschrittenen NSCLC ist schlecht, eine Chemotherapie wird in diesem Stadium mit palliativer Zielsetzung durchgeführt. Während bei einigen Patienten ein gutes Ansprechen auf eine bestimmte Chemotherapie beobachtet wird (meist Platine in Kombination mit einem anderen Präparat), kommt es bei anderen Patienten unter Chemotherapie zu einer Progression. Ein einfach zu bestimmender prognostischer Marker für das Ansprechenm auf die Chemotherapie beim NSCLC ist nicht bekannt.\r\nDie Expression von Apoptose-regulierenden Signaltransduktionsmolekülen war in etlichen in-vitro Studien mit einer besseren Chemosensitivität der Karzinomzellen verbunden. Das Ziel dieser Studie ist daher die immunhistochemische Bestimmung von Apoptoser-regulierenden Faktoren (DR4, DR5, DcR1, DcR2 und PTEN) und die Korrelation mit dem Therapieansprechen und der Überlebenszeit.", "en": "Das Bronchialkarzinom zählt zu den häufigsten malignen Erkrankungen. Die Prognose bei fortgeschrittenen NSCLC ist schlecht, eine Chemotherapie wird in diesem Stadium mit palliativer Zielsetzung durchgeführt. Während bei einigen Patienten ein gutes Ansprechen auf eine bestimmte Chemotherapie beobachtet wird (meist Platine in Kombination mit einem anderen Präparat), kommt es bei anderen Patienten unter Chemotherapie zu einer Progression. Ein einfach zu bestimmender prognostischer Marker für das Ansprechenm auf die Chemotherapie beim NSCLC ist nicht bekannt.\r\nDie Expression von Apoptose-regulierenden Signaltransduktionsmolekülen war in etlichen in-vitro Studien mit einer besseren Chemosensitivität der Karzinomzellen verbunden. Das Ziel dieser Studie ist daher die immunhistochemische Bestimmung von Apoptoser-regulierenden Faktoren (DR4, DR5, DcR1, DcR2 und PTEN) und die Korrelation mit dem Therapieansprechen und der Überlebenszeit." }, "begin_planned": "2005-08-01T02:00:00+02:00", "begin_effective": "2005-08-01T02:00:00+02:00", "end_planned": "2006-10-01T02:00:00+02:00", "end_effective": "2006-10-01T02:00:00+02:00", "assignment": "2006-03-22T14:36:41+01:00", "program": 81, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 3, "manager": 57557, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 52 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "744-50466-12", "744-51523-12", "744-51532-12", "744-57557-10", "744-78013-12" ] } ] }