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GET /v1/research/project/?format=api&offset=2120&ordering=end_effective
{ "count": 2139, "next": null, "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=2100&ordering=end_effective", "results": [ { "id": 8544, "title": { "de": "Verbindungen zwischen Aggression, Genetik und Mikrobiom", "en": "Genetic and microbial effects on aggressive behavior" }, "short": "Genetics_microbiome_aggressive behavior", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-03-01T01:00:00+01:00", "end_planned": "2029-01-01T01:00:00+01:00", "end_effective": "2029-02-28T01:00:00+01:00", "assignment": "2024-12-09T13:03:47+01:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 71386, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT5589324", "ethics_committee": null, "edudract_number": null, "persons": [ "8544-71386-10" ] }, { "id": 8233, "title": { "de": "Die Nr4a1/P53 Achse in der Immun Evasion von Lymphomen", "en": "NR4A1-P53 AXIS IN THE IMMUNE EVASION OF AGGRESSIVE LYMPHOMAS" }, "short": "LYMPHO-CHECK", "url": null, "abstract": { "de": "Aggressive Lymphome gehören zu den häufigsten Arten von Lymphdrüsenkrebs und stellen eine große Herausforderung für die Behandlung dar. Checkpoint-Blockade-Therapien (CBTs) haben sich als vielversprechender Weg erwiesen, um der Umgehung der Anti-Tumor-Immunantwort durch den Tumor entgegenzuwirken. Trotz ihres Potenzials sind CBTs mit erheblichen Kosten verbunden und basieren häufig auf Trial-and-Error-Ansätzen. Zudem sprechen nur ein kleiner Prozentsatz der Lymphom-Patienten (10-20%) auf CBT an, teilweise aufgrund eines Mangels an Verständnis darüber, wie Immun-Checkpoints während der Entwicklung von Lymphomen reguliert werden, sowie aufgrund des Fehlens prädiktiver Biomarker. Unsere jüngsten Forschungsergebnisse haben wichtige Faktoren aufgedeckt, die zu schlechten Ergebnissen bei Patienten mit diffusen großzelligen B-Zell-Lymphomen (DLBCL) beitragen. Wir beobachteten signifikante Abnahmen der NR4A1- und p53-Spiegel, die wichtige Regulatoren der Genexpression sind, vergesellschaftet mit erhöhten Checkpoint-Komponenten-Gehalt. Bei Mäusen führte die Deletion von NR4A1 zu reduzierten p53-Spiegeln, beschleunigter Lymphomentwicklung und erhöhter Expression von immuninhibitorischen Checkpoint-Komponenten. Diese Ergebnisse deuten auf eine funktionelle Beziehung zwischen NR4A1 und p53, die in der Immunantwort auf Tumore die Expression von Checkpoint-Komponenten in aggressiven Lymphomen reguliert.\r\nUnser vorgeschlagenes Forschungsprojekt zielt darauf ab, diese Herausforderungen durch die Entwicklung neuer Mausmodelle mit spezifischen Deletionen von NR4A1 und/oder p53 in B-Zellen anzugehen. Unter Verwendung fortschrittlicher molekularer und genomweiter Techniken werden wir umfassend untersuchen, wie Lymphome in diesen Modellen entstehen. Außerdem werden wir eine Methode zur wiederholten Gewebsflüssigkeitsentnahme adaptieren und damit wiederholte Messungen von Zytokinsignalen und zellulären Veränderungen in sich entwickelnden Tumoren durchführen, wodurch wertvolle Einblicke in das Lymphom-Mikromilieu gewonnen werden. Mit Hilfe dieser Modelle hoffen wir, neue Checkpoint-Blockade-Therapien für aggressive Lymphom entwickeln und auf den Status von NR4A1 und p53 abstimmen zu können. Zur Validierung unserer Ergebnisse werden wir eine große Kohorte von Lymphomproben von Patienten analysieren und mit öffentlich verfügbaren Datensätzen vergleichen. Letztendlich ist es unser Ziel, die klinische Relevanz der NR4A1-p53-Checkpoint-Achse zu bewerten und neue Biomarker zu identifizieren, die bei aggressiven Lymphomen als Entscheidungshilfe für die Behandlung mit Checkpoint-Inhibitoren dienen können. Durch unsere Forschung wollen wir die Ergebnisse für Patienten mit aggressiven Lymphomen verbessern, indem wir wirksamere und personalisierte Behandlungsstrategien entwickeln.\r\n", "en": "Aggressive lymphomas are among the most common types of lymphoid cancers and consist of Burkitt’s lymphoma, diffuse large B cell lymphoma (DLBCL), follicular lymphoma grade 3. While checkpoint blockade therapies (CBTs) have emerged as a promising avenue to counteract tumor evasion, this treatment form comes with substantial cost burdens and often rely on trial-and-error approaches. Importantly, only a small percentage of lymphoma patients (10-20%) respond favorably to CBT, partly due to the limited understanding of the regulation of immune checkpoints during lymphoma development and the absence of predictive biomarkers. Our recent investigations have shed light on key factors contributing to poor outcomes in patients with DLBCL. We observed significant decreases in the levels of NR4A1 and p53, which are important regulators of gene expression and known tumor suppressors, alongside high expression of checkpoint components. In mice, depletion of NR4A1 led to reduced p53 levels, accelerated lymphoma development, and increased expression of immune-inhibitory checkpoint components, particularly in animals with intact immune systems. These and other findings suggest a functional relationship involving NR4A1, p53, and the orchestrating immune evasive mechanisms in aggressive lymphomas.\r\nOur proposed research project aims to address this axis by developing new mouse models with specific and inducible deletion of NR4A1 and/or p53 in B cells. Using advanced molecular and genomic techniques, we will comprehensively study lymphoma development in these models. We will also implement a tissue fluid sampling method to repeatedly measure cytokine signals and cellular changes within evolving tumors, providing valuable insights into the lymphoma microenvironment. By leveraging these models, we aim to tailor CBTs based on the status of NR4A1 and p53. To clinically validate our findings, we will analyze a large cohort of lymphoma samples from GRAZ lymphoma cohort and compare them with publicly available datasets. Ultimately, our goal is to functionally establish the clinical relevance of the NR4A1-p53-checkpoint axis and identify new biomarkers that can help guide treatment decisions involving checkpoint inhibitors for aggressive lymphomas. Through our research, we are poised to improve outcomes for patients with aggressive lymphomas by developing more effective and personalized treatment strategies.\r\n" }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-06-03T02:00:00+02:00", "end_planned": "2028-12-31T01:00:00+01:00", "end_effective": "2029-06-02T02:00:00+02:00", "assignment": "2024-06-03T13:00:14+02:00", "program": 113, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 3, "manager": 59183, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "FG 30", "ethics_committee": null, "edudract_number": null, "persons": [ "8233-59183-10", "8233-79614-12", "8233-82501-12", "8233-85928-12", "8233-100134-12", "8233-122350-12", "8233-130715-12", "8233-111069-12" ] }, { "id": 8235, "title": { "de": "LYMPHO-CHECK: Lymphoma Mausmodelle und funktionelle Genomik", "en": "LYMPHO-CHECK: Lympha mouse models and functional genomics" }, "short": "LYMPHO-CHECK", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-06-03T02:00:00+02:00", "end_planned": "2029-12-31T01:00:00+01:00", "end_effective": "2029-06-02T02:00:00+02:00", "assignment": "2024-06-03T14:29:07+02:00", "program": 113, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 89979, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "FG 30", "ethics_committee": null, "edudract_number": null, "persons": [ "8235-89979-10" ] }, { "id": 8236, "title": { "de": "LYMPHO-CHECK: Bioinformatik und Data-Mining in der Lymphomforschung\r\n ", "en": "LYMPHO-CHECK: Bioinformatics and Data Mining in Lymphoma Research" }, "short": "LYMPHO-CHECK", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-06-03T02:00:00+02:00", "end_planned": "2028-12-31T01:00:00+01:00", "end_effective": "2029-06-02T02:00:00+02:00", "assignment": "2024-06-03T14:29:51+02:00", "program": 113, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 94195, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "FG 30", "ethics_committee": null, "edudract_number": null, "persons": [ "8236-94195-10" ] }, { "id": 8335, "title": { "de": "HYDrochlorothiazidE im Vergleich zu Amlodipin zur Behandlung \r\nder arteriellen Hypertonie bei hypertropher obstruktiver KardioMyopathie –\r\ndie multizentrische, randomisierte, doppelblinde, kontrollierte Crossover HYDE-HCM Studie", "en": "Randomized trial of HYDrochlorothiazidE compared to amlodipine to treat \r\narterial hypertension in patients with Hypertrophic obstructive CardioMyopathy –\r\nthe multicenter randomized double-blind controlled crossover HYDE-HCM trial" }, "short": "HYDE-HCM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-08-01T02:00:00+02:00", "begin_effective": "2024-08-01T02:00:00+02:00", "end_planned": "2029-07-31T02:00:00+02:00", "end_effective": "2029-07-31T02:00:00+02:00", "assignment": "2024-08-08T13:01:55+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 81519, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 468 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8335-81519-10" ] }, { "id": 8360, "title": { "de": "Myokardiale Strainanalyse zur Verbesserung der diagnostischen Aussagekraft von genetischen Testungen bei Hypertropher Kardiomyopathie", "en": "Myocardial deformation analysis to improve diagnostic yield of genetic testing in hypertrophic cardiomyopathy" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-08-01T02:00:00+02:00", "begin_effective": "2024-09-01T02:00:00+02:00", "end_planned": "2029-07-31T02:00:00+02:00", "end_effective": "2029-08-31T02:00:00+02:00", "assignment": "2024-08-21T10:59:10+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 106116, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 468 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8360-106116-10" ] }, { "id": 8624, "title": { "de": "CoE MetAge – Zusatzfinanzierung", "en": "CoE MetAge – Zusatzfinanzierung" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2029-09-30T02:00:00+02:00", "end_effective": "2029-09-30T02:00:00+02:00", "assignment": "2025-01-24T16:08:57+01:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 2, "manager": 94512, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": "ABT12-338847/2024-12", "ethics_committee": null, "edudract_number": null, "persons": [ "8624-94512-10" ] }, { "id": 8535, "title": { "de": "Metabolische Kontrolle von Altern und Krankheit", "en": "Metabolic control of aging and disease" }, "short": "MetAGE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2028-09-30T02:00:00+02:00", "end_effective": "2029-09-30T02:00:00+02:00", "assignment": "2024-11-29T14:49:59+01:00", "program": 125, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 2, "manager": 94512, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "COE14", "ethics_committee": null, "edudract_number": null, "persons": [ "8535-94512-10" ] }, { "id": 8536, "title": { "de": "Metabolische Kontrolle von Altern und Krankheit", "en": "Metabolic control of aging and disease" }, "short": "METAGE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2029-09-30T02:00:00+02:00", "end_effective": "2029-09-30T02:00:00+02:00", "assignment": "2024-11-29T15:01:23+01:00", "program": 125, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 2, "manager": 60041, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "COE14", "ethics_committee": null, "edudract_number": null, "persons": [ "8536-60041-10" ] }, { "id": 8602, "title": { "de": "CoE MetAge – Zusatzfinanzierung", "en": "CoE MetAge – Zusatzfinanzierung" }, "short": "CoE MetAge – Zusatzfinanzierung", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2029-09-30T02:00:00+02:00", "end_effective": "2029-09-30T02:00:00+02:00", "assignment": "2025-01-17T11:19:47+01:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 2, "manager": 91207, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": "ABT12-338847/2024-12", "ethics_committee": null, "edudract_number": null, "persons": [ "8602-91207-10" ] }, { "id": 8524, "title": { "de": "Metabolische Kontrolle von Altern und Krankheit: Von Modellen zum Menschen", "en": "Metabolic control of aging and disease: From Models to humans" }, "short": "MetAGE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2029-09-30T02:00:00+02:00", "end_effective": "2029-09-30T02:00:00+02:00", "assignment": "2024-11-21T16:12:22+01:00", "program": 125, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 1, "manager": 51831, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "COE14", "ethics_committee": null, "edudract_number": null, "persons": [ "8524-51831-10" ] }, { "id": 8527, "title": { "de": "Metabolische Kontrolle von Altern und Krankheit", "en": "Metabolic control of aging and disease" }, "short": "MetAGE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2029-09-30T02:00:00+02:00", "end_effective": "2029-09-30T02:00:00+02:00", "assignment": "2024-11-21T16:24:26+01:00", "program": 125, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 2, "manager": 91207, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "COE14", "ethics_committee": null, "edudract_number": null, "persons": [ "8527-91207-10", "8527-129219-12", "8527-108411-12" ] }, { "id": 8526, "title": { "de": "Metabolische Kontrolle von Altern und Krankheit", "en": "Metabolic control of aging and disease" }, "short": "MetAGE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2028-09-30T02:00:00+02:00", "end_effective": "2029-09-30T02:00:00+02:00", "assignment": "2024-11-21T16:12:55+01:00", "program": 125, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 71487, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "COE14", "ethics_committee": null, "edudract_number": null, "persons": [ "8526-71487-10", "8526-127474-12", "8526-116490-12", "8526-119268-12" ] }, { "id": 8525, "title": { "de": "Metabolische Kontrolle von Altern und Krankheit", "en": "Metabolic control of aging and disease" }, "short": "MetAGE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2028-09-30T02:00:00+02:00", "end_effective": "2029-09-30T02:00:00+02:00", "assignment": "2024-11-21T16:12:41+01:00", "program": 125, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51860, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "COE14", "ethics_committee": null, "edudract_number": null, "persons": [ "8525-51860-10", "8525-70922-12", "8525-124053-12", "8525-120872-12" ] }, { "id": 8412, "title": { "de": "Immunologische Evaluierung des pre-Sjögren Syndromes", "en": "Pre-Sjögren Syndrome Targeted Immunology \r\nEvaluation – The preSStige study" }, "short": "preSStige", "url": null, "abstract": { "de": "Die Sjögren Erkrankung (auch primäres Sjögren-Syndrom genannt) ist eine Autoimmunerkrankung, bei der das körpereigene Immunsystem die Speichel- und Tränendrüsen angreift und zerstört. Seltener können auch lebenswichtige Organe befallen sein. Die Erkrankung verläuft häufig schleichend weswegen sie meist sehr spät erkannt wird. Daher stammt der größte Teil des derzeitigen Wissens über die Sjögren Erkrankung von Patient*innen mit langjähriger Erkrankung. Die Symptome der Patient*innen im Frühstadium der Erkrankung, die initialen immunologischen Veränderungen und die frühen Veränderungen der Speichel- und Tränendrüsen sind völlig unbekannt. Daher gibt es derzeit auch keine Biomarker für die Frühdiagnose der Sjögren Erkrankung. Das vorliegende Projekt ist eine Zusammenarbeit zwischen universitären Zentren in Graz (Österreich) und Brest (Frankreich) und zielt darauf ab, die anfänglichen immunologischen Veränderungen der Sjögren Erkrankung aufzudecken und so die Entstehung der Erkrankung besser zu verstehen. \r\nUm dieses Ziel zu erreichen werden im vorliegenden Projekt etwa 140 Menschen mit hohem Risiko für die Entwicklung einer Sjögren Erkrankung über mehrere Jahre begleitet und eingehend untersucht. Die Methodik verbindet klinische Forschung mit modernsten Labortechniken. Mit Hilfe fortschrittlicher Instrumente werden im Rahmen der Studie eingehende Profile des Immunsystems erstellt. Techniken wie die Einzelzell-RNA-Sequenzierung und Einsatz künstlicher Intelligenz zur Diagnosevorhersage sind integrale Bestandteile des innovativen Forschungsansatzes. Mithilfe der gewonnenen Daten können immunologische Veränderungen von Studienteilnehmer*innen, die im Laufe des Beobachtungszeitraumes eine Sjögren Erkrankung entwickeln, exakt identifiziert und eingeordnet werden. Diese Erkenntnisse sollen das Verständnis zur Entstehung und die Früherkennung der Sjögren Erkrankung revolutionieren.\r\n\r\n", "en": "Sjögren's disease (also known as primary Sjögren's syndrome) is an autoimmune disease in which the body's own immune system attacks and destroys the salivary and lacrimal glands. Vital organs such as the kidneys and lungs can also be affected. The disease often progresses insidiously, which is why it is usually diagnosed very late. It is therefore clear that the majority of current knowledge about Sjögren's disease is derived from patients who have had the disease for many years. In contrast, we know little about the initial immunological events, the symptoms of patients in the early stages of the disease or the early changes in the salivary and lacrimal glands. This means that there are currently no biomarkers for the early diagnosis of Sjögren's disease. This project is a collaboration between university centres in Graz (Austria) and Brest (France). Its aim is to uncover the initial immunological changes of Sjögren's disease in order to better understand the pathogenesis of the disease. \r\nWe will achieve this goal by following and examining in detail around 140 participants at high risk of developing Sjögren's disease over several years. The methodology combines clinical research with state-of-the-art laboratory techniques. The study will create detailed profiles of the immune system using advanced instruments. Techniques such as single-cell RNA sequencing and the use of artificial intelligence for diagnosis prediction are fundamental to this innovative research approach. The data obtained will precisely identify and classify immunological changes in study participants who develop Sjögren's disease during the observation period. These findings will transform our understanding of the development and early diagnosis of Sjögren's disease.\r\n" }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2029-12-31T01:00:00+01:00", "end_effective": "2029-12-31T01:00:00+01:00", "assignment": "2024-10-02T16:37:19+02:00", "program": 111, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 3, "manager": 53560, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PIN3316924", "ethics_committee": null, "edudract_number": null, "persons": [ "8412-51002-12", "8412-53560-10", "8412-85048-12", "8412-111407-12", "8412-105947-12", "8412-120209-12", "8412-108758-12", "8412-101167-12", "8412-120630-12" ] }, { "id": 8299, "title": { "de": "Energetik-Transkriptions Kopplung im hypertensiven Herzen", "en": "Energetics-transcription coupling in hypertensive heart" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2029-12-31T01:00:00+01:00", "end_effective": "2029-12-31T01:00:00+01:00", "assignment": "2024-07-17T18:19:55+02:00", "program": 110, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 62747, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "STA 194", "ethics_committee": null, "edudract_number": null, "persons": [ "8299-62747-10", "8299-75758-12", "8299-117943-12", "8299-122231-12", "8299-110709-12", "8299-105142-12" ] }, { "id": 8079, "title": { "de": "Wirkmechanismus von Mikroplastik in entzündlichen Darmerkrankungen", "en": "Action of microplastic in inflammatory bowel diseases" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-03-01T01:00:00+01:00", "begin_effective": "2024-03-01T01:00:00+01:00", "end_planned": "2030-03-01T01:00:00+01:00", "end_effective": "2030-03-01T01:00:00+01:00", "assignment": "2024-03-11T14:44:13+01:00", "program": null, "subprogram": null, "organization": 17230, "category": 10, "type": 10, "partner_function": 4, "manager": 87298, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8079-87298-10" ] }, { "id": 8728, "title": { "de": "Vergleich der konvektive Wasserdampfablation (convective water vapor energy, WAVE™)\r\nmit dem Rezum™-System versus Holmium Laser Enukleation der Prostata (HoLEP) versus\r\nbipolare transurethrale Resektion der Prostata (TUR-P) bei Patienten mit benignen\r\nProstatasyndrom (BPS) – eine randomisierte Studie", "en": "Comparison of Convective Water Vapor Ablation (convective water vapor energy, WAVE™)\r\nwith the Rezum™ System versus Holmium Laser Enucleation of the Prostate (HoLEP) versus\r\nBipolar Transurethral Resection of the Prostate (TUR-P) in Patients with Benign Prostatic\r\nSyndrome (BPS) – A Randomized Study" }, "short": "Vektor", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2030-12-31T01:00:00+01:00", "end_effective": "2030-12-31T01:00:00+01:00", "assignment": "2025-03-17T15:43:09+01:00", "program": null, "subprogram": null, "organization": 14056, "category": 10, "type": 10, "partner_function": 3, "manager": 121670, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": 12, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8728-121670-10" ] }, { "id": 292, "title": { "de": "AT-0042 Image Processing, Information Engineering & Interdisciplinary Knowledge Exchange", "en": "AT-0042 Image Processing, Information Engineering & Interdisciplinary Knowledge Exchange" }, "short": "CEEPUS-Netzwerk AT-0042", "url": null, "abstract": { "de": "Virtual Endoscopy of Airways: \r\nApplying methods of virtual reality to Spiral Computed Tomography investigations of airways, views can be generated similar to endoscopy . These views can be used to simulate endoscopic procedures for training of residents or for planing therapeutic interventions. Moreover, the virtual camera can be sent to positions, where a real endoscope fails.\r\n\r\nVirtual Dissection of the Colon: \r\nBesides endoscopy different imaging strategies are available for detection of colonic polyps. The medical goals is to detect those polyps as early as possible in order to prevent the development of a colonic cancer. Spiral Computed Tomography (S-CT) and Magnetic Resonance Tomography (MRT), augmented by virtual reality, have already demonstrated their effectivness in the detection of colonic polyps.\r\n\r\nComputer Aided Diagnosis of Breast Cancer:\r\nA system was programmed to support the reporting radiologist as a \"never tied second reader\" by using algorithms of artificial neural nets and image processing. In addition, a graphical user interface was developed to display the results of the \"never tired second reader\" to the radiologist in a convenient way. \r\n\r\n", "en": "Virtual Endoscopy of Airways: \r\nApplying methods of virtual reality to Spiral Computed Tomography investigations of airways, views can be generated similar to endoscopy . These views can be used to simulate endoscopic procedures for training of residents or for planing therapeutic interventions. Moreover, the virtual camera can be sent to positions, where a real endoscope fails.\r\n\r\nVirtual Dissection of the Colon: \r\nBesides endoscopy different imaging strategies are available for detection of colonic polyps. The medical goals is to detect those polyps as early as possible in order to prevent the development of a colonic cancer. Spiral Computed Tomography (S-CT) and Magnetic Resonance Tomography (MRT), augmented by virtual reality, have already demonstrated their effectivness in the detection of colonic polyps.\r\n\r\nComputer Aided Diagnosis of Breast Cancer:\r\nA system was programmed to support the reporting radiologist as a \"never tied second reader\" by using algorithms of artificial neural nets and image processing. In addition, a graphical user interface was developed to display the results of the \"never tired second reader\" to the radiologist in a convenient way. \r\n\r\n" }, "begin_planned": null, "begin_effective": "1997-01-01T01:00:00+01:00", "end_planned": null, "end_effective": "9999-12-31T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": null, "subprogram": null, "organization": 14106, "category": 10, "type": 10, "partner_function": 2, "manager": 51913, "contact": 51913, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "292-51913-10" ] } ] }