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GET /v1/research/project/?format=api&offset=2120
{ "count": 2194, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=2140", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=2100", "results": [ { "id": 5419, "title": { "de": "Potential der MRT 4D-Flussbildgebung zur Charakterisierung der diastolischen Herzfunktion", "en": "Potential role of MR 4D-Flow imaging for the characterization of diastology" }, "short": "CMR2018", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-08-01T02:00:00+02:00", "begin_effective": "2018-08-01T02:00:00+02:00", "end_planned": "2021-07-31T02:00:00+02:00", "end_effective": "2022-07-31T02:00:00+02:00", "assignment": "2018-07-17T13:49:17+02:00", "program": null, "subprogram": null, "organization": 14104, "category": 10, "type": 10, "partner_function": 4, "manager": 82111, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": "17934", "ethics_committee": null, "edudract_number": null, "persons": [ "5419-82111-10" ] }, { "id": 8004, "title": { "de": "KI-basierte digitale Applikation zur Risikoeinschätzung von unklaren Hautbefunden der Glans penis – retrospektive Pilotphase ", "en": "AI-based urological application for pathological penile skin lesions - retrospective pilot study" }, "short": "UroKI", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-09-01T02:00:00+02:00", "begin_effective": "2023-10-01T02:00:00+02:00", "end_planned": "2024-05-31T02:00:00+02:00", "end_effective": "2024-05-31T02:00:00+02:00", "assignment": "2024-01-30T15:31:21+01:00", "program": null, "subprogram": null, "organization": 14056, "category": 10, "type": 10, "partner_function": 3, "manager": 113095, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8004-113095-10" ] }, { "id": 6834, "title": { "de": "Operation Nepal", "en": "Operation Nepal" }, "short": "OPNEP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-10-01T02:00:00+02:00", "begin_effective": "2021-10-01T02:00:00+02:00", "end_planned": "2022-12-31T01:00:00+01:00", "end_effective": "2022-12-31T01:00:00+01:00", "assignment": "2021-12-15T09:43:58+01:00", "program": null, "subprogram": null, "organization": 14106, "category": 10, "type": 10, "partner_function": 3, "manager": 51913, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 762 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6834-51913-10" ] }, { "id": 6186, "title": { "de": "Intermittierendes Fasten bei Typ 2 Diabetes", "en": "Intermittent fasting in type 2 diabetes" }, "short": "INTERFAST-2", "url": null, "abstract": { "de": "Intermittierendes Fasten bei Typ 2 Diabetes\r\n\r\nZunehmendes Alter, Übergewicht und Bewegungsmangel sind neben dem genetischen Background entscheidende Risikofaktoren für das Auftreten eines Diabetes mellitus Typ 2. Langfristig führt eine unzureichende Blutzuckereinstellung zusammen mit Bluthochdruck oder erhöhten Blutfetten zu einem deutlich erhöhten Risiko für Herzinfarkte, Schlaganfälle, Amputationen, Augen-, Nieren-, oder Nervenschäden bei den betroffenen Personen.\r\n\r\nInterventionsstudien haben gezeigt, dass eine Änderung des Lebensstils mit nachfolgender Reduktion des Körpergewichts zu Prävention einer Zuckerkrankheit aber auch Verbesserung der Blutzuckereinstellung bei bereits bestehendem Diabetes mellitus Typ 2 führen kann. \r\nEs gibt zahlreiche spezielle Diätinterventionen, denen allen gemeinsam ist, dass es nur wenig bis gar keine guten klinischen Studiendaten über deren Effektivität und Sicherheit bei Menschen mit Diabetes gibt. Eine populäre Diät ist das intermittierende Fasten, wo sich Esstage mit Fasttagen abwechseln. Der Einfluss einer derartigen Intervention auf die Blutzuckereinstellung aber auch die Sicherheit bei Menschen mit insulinbehandeltem Typ 2 Diabetes ist bisher noch nicht untersucht.\r\nIn unserer Studie werden PatientInnen mit Diabetes mellitus Typ 2, die eine Insulintherapie benötigen, zufällig zur Gruppe, die intermittierendes Fasten betreibt oder aber der Kontrollgruppe zugeordnet. In der 3-monatigen Studie soll vor allem der Einfluss auf das Körpergewicht, die Körperzusammensetzung, die Blutzuckereinstellung, die notwendige Insulindosis, das Wohlbefinden, den Blutdruck aber auch die Gefahr für Unterzuckerungen erhoben werden. \r\n", "en": null }, "begin_planned": "2020-07-01T02:00:00+02:00", "begin_effective": "2020-07-01T02:00:00+02:00", "end_planned": "2023-06-30T02:00:00+02:00", "end_effective": "2023-06-30T02:00:00+02:00", "assignment": "2020-07-06T11:04:16+02:00", "program": 108, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 50838, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI851", "ethics_committee": null, "edudract_number": null, "persons": [ "6186-61990-12", "6186-50838-10", "6186-57425-12", "6186-98564-12" ] }, { "id": 5639, "title": { "de": "Mikrobiomveränderungen als Indikator für einen steroid-refraktären Verlauf bei Colitis ulzerosa\r\n\r\n\r\n", "en": "Study investigating if specific fecal microbiota alterations can predict a refractory disease course to standard steroid therapy in patients with active ulcerative colitis." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-01-01T01:00:00+01:00", "begin_effective": "2019-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2021-05-31T02:00:00+02:00", "assignment": "2019-01-24T09:45:52+01:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 1, "manager": 53167, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": "17936", "ethics_committee": null, "edudract_number": null, "persons": [ "5639-53167-10" ] }, { "id": 5044, "title": { "de": "Diabetes mellitus und assoziierte Risikofaktoren bei bipolarer Störung", "en": "Diabetes mellitus und associated risk factors in bipolar disorder" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-09-01T02:00:00+02:00", "end_planned": "2018-04-01T02:00:00+02:00", "end_effective": "2021-02-28T01:00:00+01:00", "assignment": "2017-08-23T12:39:33+02:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 1, "manager": 79733, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5044-79733-10" ] }, { "id": 5810, "title": { "de": "Pilotstudie: Immunologische und mikrobielle Besonderheiten bei chronisch Schmerzkranken mit Fibromyalgie-Syndrom", "en": "Pilot study: Immunological and microbial features of patients suffering from chronic pain due to Fibromyalgia-Syndrome" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-11-01T01:00:00+01:00", "begin_effective": "2019-06-01T02:00:00+02:00", "end_planned": "2019-12-01T01:00:00+01:00", "end_effective": "2020-05-31T02:00:00+02:00", "assignment": "2019-05-27T17:16:28+02:00", "program": null, "subprogram": null, "organization": 14070, "category": 10, "type": 10, "partner_function": 4, "manager": 86560, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5810-57386-12", "5810-86560-10" ] }, { "id": 6030, "title": { "de": "Automatische Textanalyse radiologischer Befunde und Aufbau von CT basierten Trainingsdatensätzen für den zukünftigen Einsatz von Deep-Learning-Algorithmen in der radiologischen Diagnostik.", "en": "Automatic text analysis of radiological findings and development of CT-based training datasets for the future use of deep learning algorithms in radiological diagnostics." }, "short": "FutureLab.Radiology", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-09-01T02:00:00+02:00", "begin_effective": "2020-02-01T01:00:00+01:00", "end_planned": "2021-08-31T02:00:00+02:00", "end_effective": "2022-01-31T01:00:00+01:00", "assignment": "2020-01-21T14:19:31+01:00", "program": null, "subprogram": null, "organization": 14054, "category": 10, "type": 10, "partner_function": 3, "manager": 57389, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 55 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6030-57389-10" ] }, { "id": 5770, "title": { "de": "Transdisziplinäre und forschungsgeleitete Hochschullehre im Hochtechnologiebereich am Beispiel eines Mikro CTs - ein innovatives Konzept zur Stärkung des steirischen Hochschulraumes.", "en": "Transdisziplinäre und forschungsgeleitete Hochschullehre im Hochtechnologiebereich am Beispiel eines Mikro CTs - ein innovatives Konzept zur Stärkung des steirischen Hochschulraumes." }, "short": "Triple4Science", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-02-01T01:00:00+01:00", "begin_effective": "2019-02-01T01:00:00+01:00", "end_planned": "2020-04-30T02:00:00+02:00", "end_effective": "2020-07-31T02:00:00+02:00", "assignment": "2019-04-24T14:31:05+02:00", "program": null, "subprogram": null, "organization": 14054, "category": 10, "type": 10, "partner_function": 2, "manager": 57389, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 55 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5770-57389-10" ] }, { "id": 7133, "title": { "de": "Untersuchung der Nr4a1-vermittelten Regulation von Immunevasionsmechanismen in aggressiven Lymphomen", "en": "Investigation of Nr4a1-regulated immune evasion in aggressive lymphomas" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-09-01T02:00:00+02:00", "begin_effective": "2022-09-01T02:00:00+02:00", "end_planned": "2023-08-31T02:00:00+02:00", "end_effective": "2023-08-31T02:00:00+02:00", "assignment": "2022-08-17T10:03:46+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 100134, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7133-100134-10" ] }, { "id": 8482, "title": { "de": "Sport und das Ansprechen auf Immuntherapie bei Lungenkrebs.", "en": "Exercise as a tool to improve the response to immunotherapy in lung cancer." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-05-01T02:00:00+02:00", "begin_effective": "2025-03-01T01:00:00+01:00", "end_planned": "2027-05-01T02:00:00+02:00", "end_effective": "2028-02-28T01:00:00+01:00", "assignment": "2024-11-07T17:18:48+01:00", "program": 72, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 1, "manager": 71794, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT1625724", "ethics_committee": null, "edudract_number": null, "persons": [ "8482-71794-10", "8482-135562-12" ] }, { "id": 8295, "title": { "de": "Auswirkung von CD8+ T-Zelldepletion auf das Tumormikromilieu (TME) bei Nr4a1-Verlust", "en": "Effect of CD8+ T cell depletion on the tumour microenvironment (TME) in Nr4a1 loss" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-07-01T02:00:00+02:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2025-02-28T01:00:00+01:00", "end_effective": "2025-02-28T01:00:00+01:00", "assignment": "2024-07-11T11:00:10+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 100134, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": "FIF-A 16-0477/212007029", "ethics_committee": null, "edudract_number": null, "persons": [ "8295-100134-10", "8295-111069-12" ] }, { "id": 8585, "title": { "de": "AKUTE EFFEKTE UND VERTRÄGLICHKEIT VON TRAININGSBELASTUNGEN BEI LUNGENKREBSPATIENTINNEN UNTER IMMUNTHERAPIE", "en": "ACUTE EFFECTS AND TOLERABLITY OF EXERCISE IN LUNG CANCER PATIENTS UPON IMMUNOTHERAPY" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-02-01T01:00:00+01:00", "begin_effective": "2025-02-01T01:00:00+01:00", "end_planned": "2026-02-01T01:00:00+01:00", "end_effective": "2026-02-01T01:00:00+01:00", "assignment": "2025-01-07T16:03:50+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 1, "manager": 71794, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": "2024 - FB Wissenschaft 10_24", "ethics_committee": null, "edudract_number": null, "persons": [ "8585-71794-10" ] }, { "id": 8604, "title": { "de": "Die Rolle von CXCR4 in der synchronisierten Erythropoese aus humanen pluripotenten Stammzellen", "en": "The role of CXCR4 in synchronised erythropoiesis of human pluripotent stem cells" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-03-01T01:00:00+01:00", "begin_effective": "2025-03-01T01:00:00+01:00", "end_planned": "2025-04-30T02:00:00+02:00", "end_effective": "2025-04-30T02:00:00+02:00", "assignment": "2025-01-20T10:24:01+01:00", "program": null, "subprogram": null, "organization": 14058, "category": 10, "type": 10, "partner_function": 2, "manager": 96172, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1921 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8604-96172-10" ] }, { "id": 7182, "title": { "de": "Vereinfachung medizinischer Befunde mit Hilfe von künstlicher Intelligenz.", "en": "Simplification of medical reports using Artificial Intelligence." }, "short": "SimplifAI", "url": null, "abstract": { "de": "In den letzten Jahren hat sich in der medizinischen Landschaft ein Trend hin zu einer wertorientierten Gesundheitsversorgung abgezeichnet. Diese zielt darauf ab, die bestmöglichen Behandlungsergebnisse oder die bestmögliche Versorgung zu den niedrigsten Kosten zu erreichen [Porter, 2010]. Studien haben gezeigt, dass Patienten, die ihren Gesundheitszustand besser verstehen, eine höhere Therapieakzeptanz und einen besseren Heilungsverlauf aufweisen. Gut informierte und eigenverantwortliche Patienten spielen daher eine Schlüsselrolle in einem modernen patientenzentrierten Gesundheitssystem.\r\nWesentliche Informationen über eine Krankheit und die entsprechende Therapie werden in einem medizinischen Patientenbericht festgehalten. Dieser Bericht dient den behandelnden Ärzten zur Dokumentation des Zustands des Patienten und dem Informationsaustausch mit anderen Ärzten. Im Allgemeinem ist ein Patientenbericht nicht dazu gedacht, dem Patienten Informationen zu vermitteln, weshalb eine hochspezialisierte medizinische Fachsprache verwendet wird. Um dem Patienten relevante Informationen zu übermitteln, ist ein Patientengespräch üblich. Die Qualität der Informationsübermittlung hängt von den Kommunikationsfähigkeiten des Arztes und des Patienten, der für das Gespräch zur Verfügung stehenden Zeit und dem psychischen Zustand des Patienten ab.\r\nDie Verfügbarkeit elektronischer Gesundheitsakten (EHR) und das Aufkommen von Deep Learning (DL)-Technologien in der Sprachverarbeitung (NLP) ermöglichen eine semantische Analyse, um komplexe Inhalte in eine, für Patienten leicht verständliche Sprache zu übersetzen. Vor allem im deutschsprachigen, medizinischen Bereich sind DL-Techniken, aufgrund des Mangels an frei zugänglichen Daten, nicht einsetzbar. Dies ist vor allem auf strenge Datenschutzbestimmungen zurückzuführen. Ziel dieses Projekts ist die Vereinfachung deutschsprachiger klinischer Befunde mit Fokus Radiologie, um Patienten eine aktivere Rolle beim Management ihrer Gesundheit zu ermöglichen.\r\nAbseits von radiologischen Befunden ist es wichtig, das Schema für die Extraktion von medizinischen Entitäten und deren Beziehungen zueinander auf andere medizinische Bereiche auszuweiten. Für die Generierung eines heterogenen, annotierten, medizinischen Datensatzes ist die Einbindung von Expertenwissen unabdingbar. Um den Aufwand für manuelles Labeling so gering wie möglich zu halten, ist die Entwicklung einer neuartigen, einfach zu bedienenden Open-Source-Applikation ein weiterer wesentlicher Punkt in diesem Projekt.\r\nEin weiteres wichtiges Ziel ist die Analyse, inwieweit vereinfachte medizinische Befunde Patienten in einem realen Szenario zur Verfügung gestellt werden können sowie die Akzeptanz diese Befunde. Zukünftig sollen einerseits bestehende Gesundheitsdienstleister mit dieser Technologie ausgerüstet werden und andererseits Patienten in der Lage sein, über eine Webanwendung ihre medizinischen Befunde selbständig übersetzen zu lassen.\r\n", "en": "In recent years, there has been a trend in the medical landscape toward value-based healthcare. Value-based healthcare strives to achieve the best possible health outcomes or the best possible care at the lowest cost [Porter, 2010]. Studies proved that patients that better understand their health status have higher treatment compliance and a better outcome. Hence, well-informed and empowered patients play a key role in a modern patient-centered healthcare system.\r\nThe necessary information about a disease and the appropriate therapy is recorded in a medical patient report. This report is used to document the patient's state by treating physicians and to exchange information between physicians involved in the patient’s therapy. Originally, a patient report is not intended to provide information to the patient, so highly specialized medical language is used. To convey relevant information to the patient, a verbal conversation is the usual way. The quality of this information transfer is related to the doctor’s and patient’s communication skills, the time available for the conversation and the mental state of the patient, making this process highly user-dependent.\r\nThe availability of electronic health records (EHR) and the advent of Deep Learning (DL) technologies in natural language processing (NLP) now enable a semantic analysis to translate relevant content into language that medical laypeople can understand. Especially in the healthcare and clinical domain, DL techniques are rarely used as they lack available open data, which is mainly due to privacy concerns. This is even worse for German-language clinical data. In this project, we want to overcome these issues and apply text simplification for German-language clinical reports with a special focus on radiological reports to empower patients to take a more active role in managing their health.\r\nTo go beyond radiology reports, it is essential to extend the schema for medical entity and relation extraction to other medical fields. The generation of a large annotated medical corpus has to be supported by expert knowledge. To keep manual annotation costs as low as possible, the development of a novel easy to use, multiuser open-source annotation framework for human annotators is another goal of this project. It is important for this project to demonstrate the feasibility of report simplification in a real-world scenario. We are aiming to support existing healthcare providers with this technology, as well as enable patients to autonomously upload and analyze their medical reports independently.\r\n" }, "begin_planned": "2022-10-01T02:00:00+02:00", "begin_effective": "2022-10-01T02:00:00+02:00", "end_planned": "2024-09-30T02:00:00+02:00", "end_effective": "2025-02-07T01:00:00+01:00", "assignment": "2022-09-26T15:49:59+02:00", "program": 126, "subprogram": null, "organization": 14054, "category": 10, "type": 10, "partner_function": 3, "manager": 57389, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "894729", "ethics_committee": null, "edudract_number": null, "persons": [ "7182-57389-10", "7182-62787-12" ] }, { "id": 8524, "title": { "de": "Metabolische Kontrolle von Altern und Krankheit: Von Modellen zum Menschen", "en": "Metabolic control of aging and disease: From Models to humans" }, "short": "MetAGE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2029-09-30T02:00:00+02:00", "end_effective": "2029-09-30T02:00:00+02:00", "assignment": "2024-11-21T16:12:22+01:00", "program": 125, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 1, "manager": 51831, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "COE14", "ethics_committee": null, "edudract_number": null, "persons": [ "8524-51831-10" ] }, { "id": 3178, "title": { "de": "Physikalische, chemische und molekulare Mechanismen der Insulinwirkung auf implantierte Glukose-Sensor-Systeme für die künstliche Bauchspeicheldrüse", "en": "Physikalische, chemische und molekulare Mechanismen der Insulinwirkung auf implantierte Glukose-Sensor-Systeme für die künstliche Bauchspeicheldrüse" }, "short": "DSZ-Projekt", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-10-01T02:00:00+02:00", "begin_effective": "2012-10-01T02:00:00+02:00", "end_planned": "2016-04-30T02:00:00+02:00", "end_effective": "2016-09-30T02:00:00+02:00", "assignment": "2013-02-19T10:48:16+01:00", "program": 103, "subprogram": "Hans L. Merkle Stiftung Hans L. Merkle Program for Excellency in Science and Technology", "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 51831, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1388 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3178-51831-10" ] }, { "id": 5401, "title": { "de": "Virtuelle und Augmentierte Realität zur 3D Rekonstruktion", "en": "Virtual and Augmented Reality Module for 3D Reconstruction" }, "short": "enFaced", "url": "https://www.tugraz.at/index.php?id=26448", "abstract": { "de": null, "en": "This interdisciplinary research project between computer science and medicine targets the development of a comprehensive image-guided tool for head and neck surgery with the main focus on mandibular and mid-facial fractures. The tool supports the physicians in all treatment stages (diagnosis, planning, intervention and monitoring) and can also be used during clinical traineeship. A key point is the development of an algorithm for the semi-automatic and automatic segmentation of bone structures and soft tissue in CT and MRI acquisitions. A segmentation enables a three-dimensional localization, quantification and visualization of biological structures in a very short time. Based on the radiological images from the clinical routine, treatment diagnosis can be visualized, and surgical planning processes or alternative surgery options can be simulated. In addition, the postoperative simulation results can be presented preoperatively in a photo-realistic manner. In particular, this will be applied in the reposition of bony structures, the reconstruction of facial defects and the removal of tumors in complex anatomical areas. Moreover, we plan the development of patient-individual three-dimensional implants, which will 3D printed in-house for comparison with the external manufactured ones and for clinical usage. Furthermore, the medical personnel can be supported in real-time during surgery by an interactive navigation, where Augmented Reality integrates computer-generated objects into the operation field. The application reduces surgical complications and ensures a successful treatment result by pre- and intraoperative simulations. Hence, the number of necessary corrective surgeries and the operation time needed can be reduced, and a higher patient survival rate can be achieved. In addition, the combination with Virtual Reality glasses allows the virtual training of operations during medical education. The objective of the project is the establishment of an open source tool as basis for further research and developments for the participating universities. Currently, comparable tools are protected by strict licensing conditions and not accessible without restrictions for academic research. Existing software for clinical practice is not functionally stable enough and has too high error rates. Additionally, the usage imposes high financial costs, which makes a widespread application not possible. Finally, Augmented Reality in the clinical routine is an important topic for current surgical research and cannot be ignored by modern medical universities.\r\n\r\n" }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2018-07-01T02:00:00+02:00", "end_planned": "2021-12-31T01:00:00+01:00", "end_effective": "2021-09-30T02:00:00+02:00", "assignment": "2018-06-21T10:10:08+02:00", "program": 108, "subprogram": null, "organization": 14112, "category": 10, "type": 10, "partner_function": 4, "manager": 76910, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI 678-B31", "ethics_committee": null, "edudract_number": null, "persons": [ "5401-76910-10" ] }, { "id": 6021, "title": { "de": "Der Effekt von Palmitylethanolamid auf die zentrale und periphere Sensibilisierung bei gesunden Probanden - Pilotstudie", "en": "The Effect of Palmitylethanolamide on central and peripheral sensitization in healthy volunteers - Pilot Study" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-11-01T01:00:00+01:00", "begin_effective": "2019-11-01T01:00:00+01:00", "end_planned": "2020-07-06T02:00:00+02:00", "end_effective": "2021-12-31T01:00:00+01:00", "assignment": "2020-01-15T14:51:01+01:00", "program": null, "subprogram": null, "organization": 14070, "category": 10, "type": 10, "partner_function": 4, "manager": 58422, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6021-58422-10" ] }, { "id": 8414, "title": { "de": "Entschlüsselung der Auswirkungen von NR4A1 auf die Tumormikroumgebung und Interaktionen auf Immun- und Lymphomzellen in aggressiven Lymphomen", "en": "Deciphering the impact of NR4A1 on the Tumor Microenvironment and Interaction of Immune and Lymphoma Cells in aggressive Lymphoma" }, "short": null, "url": null, "abstract": { "de": "NR4A1 ist ein nukleärer Rezeptor, der eine Schlüsselrolle bei der Regulation der Tumormikroumgebung (TME) und der Interaktion zwischen Immun- und Lymphomzellen in aggressiven Lymphomen spielt. Trotz wachsender Erkenntnisse über seine Funktion bleibt unklar, wie NR4A1 die Immunantwort moduliert und das Wachstum von Lymphomzellen beeinflusst. In dieser Studie untersuchen wir die Auswirkungen von NR4A1 auf Immunzellen, insbesondere auf T-Zellen und Makrophagen, sowie auf die zellulären und molekularen Mechanismen, die zur Tumorprogression beitragen. Mithilfe modernster Einzelzell-RNA-Sequenzierung und funktioneller Immunanalysen analysieren wir die NR4A1-vermittelten Signalwege in der TME. Unsere Ergebnisse könnten neue therapeutische Ansätze zur gezielten Beeinflussung von NR4A1 in der Immunmodulation und Lymphombehandlung ermöglichen.", "en": "NR4A1 is a nuclear receptor that plays a key role in regulating the tumor microenvironment (TME) and interactions between immune and lymphoma cells in aggressive lymphomas. Despite growing insights into its function, how NR4A1 modulates immune responses and influences lymphoma cell growth remains unclear. In this study, we investigate the impact of NR4A1 on immune cells, particularly T cells and macrophages, as well as the cellular and molecular mechanisms contributing to tumor progression. Using advanced single-cell RNA sequencing and functional immune analyses, we analyze NR4A1-mediated signaling pathways in the TME. Our findings may pave the way for novel therapeutic approaches targeting NR4A1 in immune modulation and lymphoma treatment." }, "begin_planned": "2024-04-01T02:00:00+02:00", "begin_effective": "2024-06-01T02:00:00+02:00", "end_planned": "2027-04-01T02:00:00+02:00", "end_effective": "2027-05-31T02:00:00+02:00", "assignment": "2024-10-03T12:57:24+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 85928, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8414-85928-10" ] } ] }