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GET /v1/research/project/?format=api&offset=2100&ordering=-end_planned
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=2120&ordering=-end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=2080&ordering=-end_planned", "results": [ { "id": 1006, "title": { "de": "NPM-ALK gesteuerte, erhöhte Translation von JUNB im humanen großzelligen anaplastischen T-Zell Lymphom - Erforschung eines neuen Therapieansatzes", "en": "NPM-ALK gesteuerte, erhöhte Translation von JUNB im humanen großzelligen anaplastischen T-Zell Lymphom - Erforschung eines neuen Therapieansatzes" }, "short": "NPM_ALK_THERAPIE", "url": null, "abstract": { "de": "Das großzellige anaplastische T-zell Lymphom (ALCL) macht 30% aller Lymphome bei Kindern und 3% bei Erwachsenen aus. In etwa der Hälfte dieser hoch aggressiven hämatologischen Krebserkrankung findet sich die onkogene Fusionskinase NPM-ALK. In einem vorherigen Projekt konnten wir zeigen, dass das Fusionsprotein NPM-ALK zu einer selektiven Vermehrung des Transkriptionsfaktors JunB auf Proteinebene führt und dass dieser Effekt durch Behandlung mit dem Immunsuppressivum Rapamycin wieder rückgängig gemacht werden kann. Das hier eingereichte Projekt soll prüfen, wie NPM-ALK die Translation von JunB steuert, und zu welchen funktinellen Auswirkungen dies führt. In diesem Zusammenhang wollen wir die Rolle des NPM-ALK Moleküls selbst, und die seiner verschiedenen Phosphorylierungsstellen untersuchen. Schließlich soll die funktionelle Bedeutung der hohen JunB-Expression in ALCL mittels verschiedener knock-down Strategien geklärt, und seine Bedeutung als Ziel einer Therapie überprüft werden. Dieses Projekt charakerisiert, wie eine onkogene Fusionskinase Translation reguliert, welche Bedeutung dies für die Lymphomagenese hat, und wie ein neuer effektiver Therapieweg mit geringer Toxizität aussehen kann, der spezifisch auf die Translation nachgeschalteter Onkogene wirkt.", "en": "Das großzellige anaplastische T-zell Lymphom (ALCL) macht 30% aller Lymphome bei Kindern und 3% bei Erwachsenen aus. In etwa der Hälfte dieser hoch aggressiven hämatologischen Krebserkrankung findet sich die onkogene Fusionskinase NPM-ALK. In einem vorherigen Projekt konnten wir zeigen, dass das Fusionsprotein NPM-ALK zu einer selektiven Vermehrung des Transkriptionsfaktors JunB auf Proteinebene führt und dass dieser Effekt durch Behandlung mit dem Immunsuppressivum Rapamycin wieder rückgängig gemacht werden kann. Das hier eingereichte Projekt soll prüfen, wie NPM-ALK die Translation von JunB steuert, und zu welchen funktinellen Auswirkungen dies führt. In diesem Zusammenhang wollen wir die Rolle des NPM-ALK Moleküls selbst, und die seiner verschiedenen Phosphorylierungsstellen untersuchen. Schließlich soll die funktionelle Bedeutung der hohen JunB-Expression in ALCL mittels verschiedener knock-down Strategien geklärt, und seine Bedeutung als Ziel einer Therapie überprüft werden. Dieses Projekt charakerisiert, wie eine onkogene Fusionskinase Translation reguliert, welche Bedeutung dies für die Lymphomagenese hat, und wie ein neuer effektiver Therapieweg mit geringer Toxizität aussehen kann, der spezifisch auf die Translation nachgeschalteter Onkogene wirkt." }, "begin_planned": "2007-02-01T01:00:00+01:00", "begin_effective": "2007-02-01T01:00:00+01:00", "end_planned": "2009-02-28T01:00:00+01:00", "end_effective": "2009-02-28T01:00:00+01:00", "assignment": "2007-01-15T14:23:40+01:00", "program": 79, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1006-50903-12", "1006-54011-12", "1006-57409-11", "1006-51691-11" ] }, { "id": 1488, "title": { "de": "NANO-HEALTH: NanoSTEM: 4-D-MOLECULAR IMAGING OF HUMAN STEM CELLS", "en": "NANO-HEALTH: NanoSTEM: 4-D-MOLECULAR IMAGING OF HUMAN STEM CELLS" }, "short": "NANO-HEALTH_NANOSTEM", "url": null, "abstract": { "de": "Regenerative stem cell therapy is a novel therapeutic concept aiming to support organ regeneration after ischemic, metabolic or toxic injury by stem cell transplantation. Target diseases include cardiovascular and metabolic disorders, neurodegenerative conditions as well as immunological diseases being only the most common examples. Based on a growing amount of experimental data and early clinical observations regenerative stem cell therapy is currently translated into a growing number of groundbreaking clinical trials. One of the major limitations for understanding and consecutive optimization of regenerative stem cell therapy is a definitive lack of technology that allows monitoring the fate of the transplated stem cells after application.\r\nThe main objective of the proposed project is to utilize nanoparticles with high signalling capacity in magnetic resonance imaging to target human stem cells for high resolution molecular imaging. To accomplish this goal this project will access readily established leading technology for clinical scale propagation of human stem cells under good manufacturing practice resulting in immediate availability of reasonable quantities of billions of stem cells at highest quality.", "en": "Regenerative stem cell therapy is a novel therapeutic concept aiming to support organ regeneration after ischemic, metabolic or toxic injury by stem cell transplantation. Target diseases include cardiovascular and metabolic disorders, neurodegenerative conditions as well as immunological diseases being only the most common examples. Based on a growing amount of experimental data and early clinical observations regenerative stem cell therapy is currently translated into a growing number of groundbreaking clinical trials. One of the major limitations for understanding and consecutive optimization of regenerative stem cell therapy is a definitive lack of technology that allows monitoring the fate of the transplated stem cells after application.\r\nThe main objective of the proposed project is to utilize nanoparticles with high signalling capacity in magnetic resonance imaging to target human stem cells for high resolution molecular imaging. To accomplish this goal this project will access readily established leading technology for clinical scale propagation of human stem cells under good manufacturing practice resulting in immediate availability of reasonable quantities of billions of stem cells at highest quality." }, "begin_planned": "2007-03-01T01:00:00+01:00", "begin_effective": "2007-03-01T01:00:00+01:00", "end_planned": "2009-02-28T01:00:00+01:00", "end_effective": "2009-02-28T01:00:00+01:00", "assignment": "2008-03-10T17:12:03+01:00", "program": null, "subprogram": "FWF: Nano Initiative", "organization": 14082, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "N211", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 276, "title": { "de": "SAFE: Special Non-Invasive Advances in Foetal and Neonatal Evaluation Network ", "en": "SAFE: Special Non-Invasive Advances in Foetal and Neonatal Evaluation Network " }, "short": "SAFE", "url": null, "abstract": { "de": "The establishment of non-invasive markers for prenatal diagnosis and neo-natal screening is a very important research goal. Current invasive procedures have (1)a significant risk of induced abortion (1-2%) or maternal injury and (2) considerable discomfort and psycological distress. Currently around 5 % of pregnant women in the developed world undergo invasive prenatal diagnosis procedures, mainly due to an increased risk for foetal chromosome abnormalities(such as trisomy 21 Down syndrome). In populations with a high penetrance of an inherited genetic disorder, such as the hemoglobinopathies, cystic fibrosis or Tay Sachs syndrome, it may be advantageous to determine the genotype early in life (neonates), as this will alert individuals, who are found o be carriers of the risk of having an affected child.\r\nThe transplacental passage of foetal cells into the maternal circulation is now well established, and a number of studies have been undertaken in order to isolate these rare foetal cells for prenatal diagnostic purposes. In spite of the technical problems imposed by the scarcity of these foetal cells, substantial progress has been made by individual research groups in Europe. There is now an urgent need to integrate these fragmented and diverse activities into a coherent strategy for non-invasive prenatal diagnosis.\r\nThe recent discovery of relatively abundant quantities of cell free DNA in maternal plasma and serum has opened a new avenue for the prenatal diagnosis of the latter group of genetic disorders as well as the determination of the foetal RhD genotype in pregnancies at risk for HDN (haemolytic disease of the foetus and newborn). In addition elevations in the concentration of the new found molecular analyte may be indicative of pregnancies bearing an aneuploid foetus or those at risk for pregnancy related disorders such as preterm labour or preeclampsia. This opens the possibility for new screening tools.\r\nThe advent of high throughput gene-CHIP technology will facilitate effective screening programs for common inherited genetic disorders. Thir will alert individuals to the possibility of having an affected foetus if the partner has a certain genetic constellation; a frequent dispensation in certain populations. The program will create a leading European Network of Excellence in the area of non-invasive prenatal diagnosis and neonatal screening.", "en": "The establishment of non-invasive markers for prenatal diagnosis and neo-natal screening is a very important research goal. Current invasive procedures have (1)a significant risk of induced abortion (1-2%) or maternal injury and (2) considerable discomfort and psycological distress. Currently around 5 % of pregnant women in the developed world undergo invasive prenatal diagnosis procedures, mainly due to an increased risk for foetal chromosome abnormalities(such as trisomy 21 Down syndrome). In populations with a high penetrance of an inherited genetic disorder, such as the hemoglobinopathies, cystic fibrosis or Tay Sachs syndrome, it may be advantageous to determine the genotype early in life (neonates), as this will alert individuals, who are found o be carriers of the risk of having an affected child.\r\nThe transplacental passage of foetal cells into the maternal circulation is now well established, and a number of studies have been undertaken in order to isolate these rare foetal cells for prenatal diagnostic purposes. In spite of the technical problems imposed by the scarcity of these foetal cells, substantial progress has been made by individual research groups in Europe. There is now an urgent need to integrate these fragmented and diverse activities into a coherent strategy for non-invasive prenatal diagnosis.\r\nThe recent discovery of relatively abundant quantities of cell free DNA in maternal plasma and serum has opened a new avenue for the prenatal diagnosis of the latter group of genetic disorders as well as the determination of the foetal RhD genotype in pregnancies at risk for HDN (haemolytic disease of the foetus and newborn). In addition elevations in the concentration of the new found molecular analyte may be indicative of pregnancies bearing an aneuploid foetus or those at risk for pregnancy related disorders such as preterm labour or preeclampsia. This opens the possibility for new screening tools.\r\nThe advent of high throughput gene-CHIP technology will facilitate effective screening programs for common inherited genetic disorders. Thir will alert individuals to the possibility of having an affected foetus if the partner has a certain genetic constellation; a frequent dispensation in certain populations. The program will create a leading European Network of Excellence in the area of non-invasive prenatal diagnosis and neonatal screening." }, "begin_planned": "2004-03-01T01:00:00+01:00", "begin_effective": "2004-03-01T01:00:00+01:00", "end_planned": "2009-02-28T01:00:00+01:00", "end_effective": "2009-02-28T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 21, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1306, "title": { "de": "IMPACTS: ARCHIVE´S TISSUES: IMPROVING MOLECULAR MEDICINE RESEARCH AND CLINICAL PRACTICE", "en": "IMPACTS: ARCHIVE´S TISSUES: IMPROVING MOLECULAR MEDICINE RESEARCH AND CLINICAL PRACTICE" }, "short": "IMPACTS", "url": null, "abstract": { "de": "Nowadays, emerging capabilities are being introduced to a more personalized molecular approach in medicine with individual risk assessment and best suited care. An important tool for translation research in this field is the large number of human archive's tissues, with any kind of disease, stored in hospitals all over Europe. Tissues from biopsies or surgical therapy are fixed and paraffin embedded to obtain a histopathology diagnosis, and then stored in archives for many decades. We developed already the technology that allows molecular research at DNA and RNA level in paraffin embedded tissues, so that the findings can be evaluated in the proper context. These methods were first designed by European scientists. In this way it is easy to study lesions with known therapy outcomes. There is the opportunity of this European Coordination Action ín advanced genomics to improve and speed up clinical applications for health and also for R&D of European biotechnology companies.\r\nExpected results of the Action are integrating European molecular research with a faster dissemination and application of molecular methods in clinical practice, preparing the opportunity of new multicentric functional gemonics research projects, stimulating technology innovation with industrial collaboratiion in the fields of gene expression analysis and proteomics.", "en": "Nowadays, emerging capabilities are being introduced to a more personalized molecular approach in medicine with individual risk assessment and best suited care. An important tool for translation research in this field is the large number of human archive's tissues, with any kind of disease, stored in hospitals all over Europe. Tissues from biopsies or surgical therapy are fixed and paraffin embedded to obtain a histopathology diagnosis, and then stored in archives for many decades. We developed already the technology that allows molecular research at DNA and RNA level in paraffin embedded tissues, so that the findings can be evaluated in the proper context. These methods were first designed by European scientists. In this way it is easy to study lesions with known therapy outcomes. There is the opportunity of this European Coordination Action ín advanced genomics to improve and speed up clinical applications for health and also for R&D of European biotechnology companies.\r\nExpected results of the Action are integrating European molecular research with a faster dissemination and application of molecular methods in clinical practice, preparing the opportunity of new multicentric functional gemonics research projects, stimulating technology innovation with industrial collaboratiion in the fields of gene expression analysis and proteomics." }, "begin_planned": "2007-03-01T01:00:00+01:00", "begin_effective": "2007-03-01T01:00:00+01:00", "end_planned": "2009-02-28T01:00:00+01:00", "end_effective": "2010-02-28T01:00:00+01:00", "assignment": "2007-06-22T13:04:30+02:00", "program": 21, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51523, "contact": 51523, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1306-50598-12", "1306-51523-10" ] }, { "id": 1446, "title": { "de": "NANO-HEALTH: Nano-Plaque", "en": "NANO-HEALTH: Nano-Plaque" }, "short": "NANO-HEALTH_NANO_PLAQUE", "url": null, "abstract": { "de": "Das Projekt Nano Plaque ist integraler Bestandteil des Nano-Health Projektes, das sich aus 13 Forschungsprojekten zur Entwicklung neuer Nanopartikel (NPs) für Diagnose, Bildgebung und Wirkstofftransport zusammensetzt. \r\n\r\nNano Plaque adressiert die Frühdiagnostik und Therapie von Atherosklerose mittels Grundlagenforschung. Zu diesem Zweck wurde ein Tiermodell (ApoE defiziente Maus) etabliert. ApoE defiziente Mäuse entwickeln multilokuläre atherosklerotische Läsionen. Multifunktionale Nanopartikel werden mit monoklonalen Antikörpern oder Biomarkern konjugiert. Solche mit Gadolinium markierte Nanopartikel/Antikörper bzw. Biomarker Komplexe werden auf ihr Potential zur Erkennung von Zielstrukturen im Plaque untersucht. Zur Detektion wird ein Hochenergie 3 Tesla Kernspintomograph (Siemens Trio) eingesetzt. Weiters sollen die NP-Komplexe neben der selektiven bildgebenen Diagnostik bezüglich ihres Potentials als Träger für hochwirksame Therapiesubstanzen (z.B.: Entzündungs-hemmende Biologica) untersucht werden. ", "en": "Introduction, Background and Aims:\r\n\r\nNano-Plaque is part of the Nano-Health project, which consists of 13 research projects aiming to develop new generations of nanoparticles (NPs) for diagnosis, imaging and drug delivery. \r\n\r\nThe main objective of Nano Plaque is to address more in depth prospects of improved diagnosis of atherosclerosis complementary to the clinical studies STYJOBS/EDECTA by means of basic science. An animal model for atherosclerotic lesions, the ApoE deficient mouse, is used. Biomarkers which play an important role in the atherosclerotic plaque scenario, and binding domain fragments of antibodies against such biomarkers, will be coupled with NPs to investigate the potential of nanotechnology for an improved diagnosis of atherosclerotic plaques. These NP-biomarker, or NP-antibody fragment complexes will be investigated towards their potency to characterise critical scenarios within plaque lesions of the vascular wall. New imaging methods such as 3Tesla NMRI will be used for the visualisation. \r\n\r\n" }, "begin_planned": "2007-03-01T01:00:00+01:00", "begin_effective": "2007-03-01T01:00:00+01:00", "end_planned": "2009-02-28T01:00:00+01:00", "end_effective": "2009-02-28T01:00:00+01:00", "assignment": "2008-01-15T11:01:33+01:00", "program": null, "subprogram": "FWF: Nano Initiative", "organization": 14028, "category": 10, "type": 10, "partner_function": 2, "manager": 52854, "contact": 52854, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "N212", "ethics_committee": null, "edudract_number": null, "persons": [ "1446-52854-10" ] }, { "id": 738, "title": { "de": "SAFE: Special Non-Invasive Advances in Foetal and Neonatal Evaluation Network", "en": "SAFE: Special Non-Invasive Advances in Foetal and Neonatal Evaluation Network" }, "short": "SAFE", "url": null, "abstract": { "de": "The establishment of non-invasive markers for prenatal diagnosis and neo-natal screening is a very important research goal. Current invasive procedures have (1)a significant risk of induced abortion (1-2%) or maternal injury and (2) considerable discomfort and psycological distress. Currently around 5 % of pregnant women in the developed world undergo invasive prenatal diagnosis procedures, mainly due to an increased risk for foetal chromosome abnormalities(such as trisomy 21 Down syndrome). In populations with a high penetrance of an inherited genetic disorder, such as the hemoglobinopathies, cystic fibrosis or Tay Sachs syndrome, it may be advantageous to determine the genotype early in life (neonates), as this will alert individuals, who are found o be carriers of the risk of having an affected child.\r\nThe transplacental passage of foetal cells into the maternal circulation is now well established, and a number of studies have been undertaken in order to isolate these rare foetal cells for prenatal diagnostic purposes. In spite of the technical problems imposed by the scarcity of these foetal cells, substantial progress has been made by individual research groups in Europe. There is now an urgent need to integrate these fragmented and diverse activities into a coherent strategy for non-invasive prenatal diagnosis.\r\nThe recent discovery of relatively abundant quantities of cell free DNA in maternal plasma and serum has opened a new avenue for the prenatal diagnosis of the latter group of genetic disorders as well as the determination of the foetal RhD genotype in pregnancies at risk for HDN (haemolytic disease of the foetus and newborn). In addition elevations in the concentration of the new found molecular analyte may be indicative of pregnancies bearing an aneuploid foetus or those at risk for pregnancy related disorders such as preterm labour or preeclampsia. This opens the possibility for new screening tools.\r\nThe advent of high throughput gene-CHIP technology will facilitate effective screening programs for common inherited genetic disorders. Thir will alert individuals to the possibility of having an affected foetus if the partner has a certain genetic constellation; a frequent dispensation in certain populations. The program will create a leading European Network of Excellence in the area of non-invasive prenatal diagnosis and neonatal screening.", "en": "The establishment of non-invasive markers for prenatal diagnosis and neo-natal screening is a very important research goal. Current invasive procedures have (1)a significant risk of induced abortion (1-2%) or maternal injury and (2) considerable discomfort and psycological distress. Currently around 5 % of pregnant women in the developed world undergo invasive prenatal diagnosis procedures, mainly due to an increased risk for foetal chromosome abnormalities(such as trisomy 21 Down syndrome). In populations with a high penetrance of an inherited genetic disorder, such as the hemoglobinopathies, cystic fibrosis or Tay Sachs syndrome, it may be advantageous to determine the genotype early in life (neonates), as this will alert individuals, who are found o be carriers of the risk of having an affected child.\r\nThe transplacental passage of foetal cells into the maternal circulation is now well established, and a number of studies have been undertaken in order to isolate these rare foetal cells for prenatal diagnostic purposes. In spite of the technical problems imposed by the scarcity of these foetal cells, substantial progress has been made by individual research groups in Europe. There is now an urgent need to integrate these fragmented and diverse activities into a coherent strategy for non-invasive prenatal diagnosis.\r\nThe recent discovery of relatively abundant quantities of cell free DNA in maternal plasma and serum has opened a new avenue for the prenatal diagnosis of the latter group of genetic disorders as well as the determination of the foetal RhD genotype in pregnancies at risk for HDN (haemolytic disease of the foetus and newborn). In addition elevations in the concentration of the new found molecular analyte may be indicative of pregnancies bearing an aneuploid foetus or those at risk for pregnancy related disorders such as preterm labour or preeclampsia. This opens the possibility for new screening tools.\r\nThe advent of high throughput gene-CHIP technology will facilitate effective screening programs for common inherited genetic disorders. Thir will alert individuals to the possibility of having an affected foetus if the partner has a certain genetic constellation; a frequent dispensation in certain populations. The program will create a leading European Network of Excellence in the area of non-invasive prenatal diagnosis and neonatal screening." }, "begin_planned": "2004-03-01T01:00:00+01:00", "begin_effective": "2004-03-01T01:00:00+01:00", "end_planned": "2009-02-28T01:00:00+01:00", "end_effective": "2009-02-28T01:00:00+01:00", "assignment": "2006-03-07T16:00:05+01:00", "program": 21, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 51719, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "738-51719-10" ] }, { "id": 1507, "title": { "de": "Styrian Genomic Arthritis Project (Sty-gap)", "en": "Styrian Genomic Arthritis Project (Sty-gap)" }, "short": "Sty-gap", "url": null, "abstract": { "de": "Arthrose ist eine der häufigsten Erkrankungen des älteren Menschen. Studien ergaben, dass von 1/3 der Erwachsenen zwischen 25 und 74 Jahren ein arthrosekrankes Gelenk besitzen.\r\nSchmerz und Immobilisation sowie operative Eingriffe belasten diese Patienten. Hohe Kosten für konservative und vor allem operative Therapien lassen die Ausgaben der öffentlichen Hand steigen. Es ist mit einem dramatischen Anstieg der Erkrankten und der dadurch verursachten Kosten auf Grund der natürlichen Bevölkerungsentwicklung in Österreich zu rechnen. Trotz dem Einsatz moderner Forschungsmethoden und der Förderung und Thematisierung durch die WHO gibt es immer noch nur ein bruchteilhaftes Verständnis der Faktoren die den gesunden belastungsfähigen Knorpel degenerieren lassn. Um kausale und präventive Therapien gegen Arthrose entwickeln zu können, ist die Kenntnis der spezifischen Faktoren, die zu dieser multifaktoriellen Erkrankung führen, Voraussetzung. Das eingereichte Projekt widmet sich dieser Fragestellung.\r\nUm Ursachen dieser Erkrankung zu erforschen, müssen gesunde mit erkrankten Individuen verglichen werden: Ein umfangreiches Patientenkollektiv muss gebildet werden. Durch exakte Erhebung und Dokumentation klinischer und serologischer Parameter sowie bioptisch gewonnenem Gewebe von Patienten, die sich einem endoprothetischen Geleksersatz unterziehen, können Aussagen über maßgebliche Faktoren der Arthroseentstehung getroffen werden. Eine Beobachtung und Analyse des Arthroseverlaufes über einen Zeitraum von 10 Jahren lässt wichtige Ergebnisse im Langzeitverlauf erwarten. Die Beobachtung familiärer Häufung der Arthrose gibt einen eindeutigen Hinweis auf genetische Faktoren bei der Entstehung der Arthrose. Um diesem Umstand Rechnung zu tragen, wird eine DNA-Bank angelegt. Von jedem in das Kollektiv eingeschlossenen Patienten, wird eine DNA-Probe angelegt. Durch die Analyse der Gesamtheit Arthrose verursachender Parameter, ist die exakte Definition der Ursachen von Arthrose und Etablierung erfolgreicher Behandlungsstrategien das Ziel dieser Studie. Risikofaktoren können so definiert und präventive Maßnahmen etabliert werden.", "en": "Arthrose ist eine der häufigsten Erkrankungen des älteren Menschen. Studien ergaben, dass von 1/3 der Erwachsenen zwischen 25 und 74 Jahren ein arthrosekrankes Gelenk besitzen.\r\nSchmerz und Immobilisation sowie operative Eingriffe belasten diese Patienten. Hohe Kosten für konservative und vor allem operative Therapien lassen die Ausgaben der öffentlichen Hand steigen. Es ist mit einem dramatischen Anstieg der Erkrankten und der dadurch verursachten Kosten auf Grund der natürlichen Bevölkerungsentwicklung in Österreich zu rechnen. Trotz dem Einsatz moderner Forschungsmethoden und der Förderung und Thematisierung durch die WHO gibt es immer noch nur ein bruchteilhaftes Verständnis der Faktoren die den gesunden belastungsfähigen Knorpel degenerieren lassn. Um kausale und präventive Therapien gegen Arthrose entwickeln zu können, ist die Kenntnis der spezifischen Faktoren, die zu dieser multifaktoriellen Erkrankung führen, Voraussetzung. Das eingereichte Projekt widmet sich dieser Fragestellung.\r\nUm Ursachen dieser Erkrankung zu erforschen, müssen gesunde mit erkrankten Individuen verglichen werden: Ein umfangreiches Patientenkollektiv muss gebildet werden. Durch exakte Erhebung und Dokumentation klinischer und serologischer Parameter sowie bioptisch gewonnenem Gewebe von Patienten, die sich einem endoprothetischen Geleksersatz unterziehen, können Aussagen über maßgebliche Faktoren der Arthroseentstehung getroffen werden. Eine Beobachtung und Analyse des Arthroseverlaufes über einen Zeitraum von 10 Jahren lässt wichtige Ergebnisse im Langzeitverlauf erwarten. Die Beobachtung familiärer Häufung der Arthrose gibt einen eindeutigen Hinweis auf genetische Faktoren bei der Entstehung der Arthrose. Um diesem Umstand Rechnung zu tragen, wird eine DNA-Bank angelegt. Von jedem in das Kollektiv eingeschlossenen Patienten, wird eine DNA-Probe angelegt. Durch die Analyse der Gesamtheit Arthrose verursachender Parameter, ist die exakte Definition der Ursachen von Arthrose und Etablierung erfolgreicher Behandlungsstrategien das Ziel dieser Studie. Risikofaktoren können so definiert und präventive Maßnahmen etabliert werden." }, "begin_planned": "2008-05-01T02:00:00+02:00", "begin_effective": "2008-05-01T02:00:00+02:00", "end_planned": "2009-02-28T01:00:00+01:00", "end_effective": "2011-01-01T01:00:00+01:00", "assignment": "2008-04-04T14:18:43+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1511, "title": { "de": "ASER-Triboskop", "en": "ASER-Triboskop" }, "short": "ASER-Triboskop", "url": null, "abstract": { "de": "Die Implantation von Hüftendoprothesen zählt zu einer der häufigsten Operationen in der westlichen Welt.\r\nDer derzeit limitierende Faktor (abgesehen von bakteriellen Infekten in 0,5-0,8%) besteht im Materialverschleiß der so genannten Gleitpaarungen. Das sind im Falle des Hüftgelenkes der Prothesenkopf und der Pfanneneinsatz. Hier kommt es durch unterschiedliche, teilweise noch nicht in vollem Umfang bekannten Faktoren zu Materialabrieb und in letzter Konsequenz zu Funktionseinbußen bis zum völligen Versagen der Prothese. Einer dieser Mechanismen besteht im Auftreten einer lokalen chronischen Entzündungsreaktion ausgelöst durch Abriebpartikel mit folgender Lockerung des Implantats, welches dann in einer Revisionsoperation ausgetauscht werden muss.\r\n\r\nEine Methode, um die frühzeitige Abnutzung von Prothesen rechtzeitig zu diagnostizieren, gibt es in adäquater Weise bisher nicht. Daher haben wir, in Kooperation mit dem Institut für Krankenhaustechnik mit Prüfstelle für Medizinprodukte der TU-Graz ein Vibrationsmessgerät (ASER) entwickelt, das in der Lage sein wird, von der Hautoberfläche des Patienten aus den Prothesenabrieb nachzuweisen, bevor er klnisch manifest wird.\r\nUnser Ziel ist somit die Etablierung einer einfachen, reproduzierbaren, nebenwirkungsfreien und kostengünstigen Untersuchungsmethode zur Beurteilung des Zustandes und der Funktion einer Hüfttotalendoprothese.", "en": "Die Implantation von Hüftendoprothesen zählt zu einer der häufigsten Operationen in der westlichen Welt.\r\nDer derzeit limitierende Faktor (abgesehen von bakteriellen Infekten in 0,5-0,8%) besteht im Materialverschleiß der so genannten Gleitpaarungen. Das sind im Falle des Hüftgelenkes der Prothesenkopf und der Pfanneneinsatz. Hier kommt es durch unterschiedliche, teilweise noch nicht in vollem Umfang bekannten Faktoren zu Materialabrieb und in letzter Konsequenz zu Funktionseinbußen bis zum völligen Versagen der Prothese. Einer dieser Mechanismen besteht im Auftreten einer lokalen chronischen Entzündungsreaktion ausgelöst durch Abriebpartikel mit folgender Lockerung des Implantats, welches dann in einer Revisionsoperation ausgetauscht werden muss.\r\n\r\nEine Methode, um die frühzeitige Abnutzung von Prothesen rechtzeitig zu diagnostizieren, gibt es in adäquater Weise bisher nicht. Daher haben wir, in Kooperation mit dem Institut für Krankenhaustechnik mit Prüfstelle für Medizinprodukte der TU-Graz ein Vibrationsmessgerät (ASER) entwickelt, das in der Lage sein wird, von der Hautoberfläche des Patienten aus den Prothesenabrieb nachzuweisen, bevor er klnisch manifest wird.\r\nUnser Ziel ist somit die Etablierung einer einfachen, reproduzierbaren, nebenwirkungsfreien und kostengünstigen Untersuchungsmethode zur Beurteilung des Zustandes und der Funktion einer Hüfttotalendoprothese." }, "begin_planned": "2008-05-01T02:00:00+02:00", "begin_effective": "2008-05-01T02:00:00+02:00", "end_planned": "2009-02-28T01:00:00+01:00", "end_effective": "2009-02-28T01:00:00+01:00", "assignment": "2008-04-09T17:06:38+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 58004, "contact": 58004, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1511-58004-10" ] }, { "id": 1454, "title": { "de": "CONTICA: Control of Intracellular Calcium and Arrhythmias", "en": "Control of Intracellular Calcium and Arrhythmias" }, "short": "CONTICA", "url": null, "abstract": { "de": "Ventricular arrhythmias are a major cause of mortality. Currently there is no effective treatment available, largely because our understanding of their molecular basis is poor. Altered intracellular Ca handling may be a final common pathway predisposing to ventricular tachycardias and sudden death in acquired or congenital heart disease.\r\nUnderstanding the complex function of the RyR2 Ca channel and its regulatory mechanisms, therefore, holds the promise to develop new diagnostic and therapeutic strategies for effective treatment of these lethal arrhythmias. \r\nThe goal pursued by the CONTICA group is the elucidation of the molecular mechanisms linking defective RyR2 function to the generation of arrhythmias.\r\nThe combined knowledge gained from these studies will be used to develop and test novel diagnostic approaches and antiarrhythmic drugs to help alleviate one of the largest health burdens to the European society, i.e. malignant ventricular arrhythmias.", "en": "Ventricular arrhythmias are a major cause of mortality. Currently there is no effective treatment available, largely because our understanding of their molecular basis is poor. Altered intracellular Ca handling may be a final common pathway predisposing to ventricular tachycardias and sudden death in acquired or congenital heart disease.\r\nUnderstanding the complex function of the RyR2 Ca channel and its regulatory mechanisms, therefore, holds the promise to develop new diagnostic and therapeutic strategies for effective treatment of these lethal arrhythmias. \r\nThe goal pursued by the CONTICA group is the elucidation of the molecular mechanisms linking defective RyR2 function to the generation of arrhythmias.\r\nThe combined knowledge gained from these studies will be used to develop and test novel diagnostic approaches and antiarrhythmic drugs to help alleviate one of the largest health burdens to the European society, i.e. malignant ventricular arrhythmias." }, "begin_planned": "2007-02-01T01:00:00+01:00", "begin_effective": "2006-02-01T01:00:00+01:00", "end_planned": "2009-01-31T01:00:00+01:00", "end_effective": "2009-07-31T02:00:00+02:00", "assignment": "2008-01-22T11:15:08+01:00", "program": 21, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 3, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1454-60041-12" ] }, { "id": 917, "title": { "de": "MICRO-WEDGE", "en": "MICRO-WEDGE" }, "short": "MICRO-WEDGE", "url": null, "abstract": { "de": "Several multicenter clinical trials have provided consistent evidence that implantable defibrillation therapy prolongs patient life. This convincing demonstration of the efficacy of defibrillation has led to a nearly exponential growth, over the last decade, in the number of patients receiving implantable devices. The current wide application of defibrillation raises new concerns regarding the safety and optimization of the therapy. Improved understanding of defibrillation mechanisms is therefore\r\nimperative to the development of better and safer strategies for prevention of sudden cardiac death. Despite the importance of this therapy, understanding of mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete. While recent experimental advances have provided new characterizations of tissue\r\nresponses to shocks, mechanistic inquiry into the success and failure of defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles.\r\nThe overall objective of this research is, by employing realistic 3D computer simulations, to bring a new level of understanding of the post-shock events in the heart that lead to the failure of the shock. Current models do not incorporate anatomical microheterogeneities, which could play an important role. Specifically, this project proposes to examine, in bidomain models of cardiac micro-structure, mechanisms underlying the ``isoelectric window\", the quiescent period often preceding the first postshock activation following failed shocks. We hypothesize that the isoelectric window arises from small-scale shock-induced polarization, such as polarization of trabeculae and papillary muscle. Understanding the isoelectric window mechanisms could pave the way to new strategies for extending it indefinitely, and thus converting a failed shock into a successful one.", "en": "Several multicenter clinical trials have provided consistent evidence that implantable defibrillation therapy prolongs patient life. This convincing demonstration of the efficacy of defibrillation has led to a nearly exponential growth, over the last decade, in the number of patients receiving implantable devices. The current wide application of defibrillation raises new concerns regarding the safety and optimization of the therapy. Improved understanding of defibrillation mechanisms is therefore\r\nimperative to the development of better and safer strategies for prevention of sudden cardiac death.\r\nDespite the importance of this therapy, understanding of mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete. While recent experimental advances have provided new characterizations of tissue\r\nresponses to shocks, mechanistic inquiry into the success and failure of defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles.\r\nThe overall objective of this research is, by employing realistic 3D computer simulations, to bring a new level of understanding of the post-shock events in the heart that lead to the failure of the shock. Current models do not incorporate anatomical microheterogeneities, which could play an important role. Specifically, this project proposes to examine, in bidomain models of cardiac micro-structure, mechanisms underlying the ``isoelectric window\", the quiescent period often preceding the first postshock activation following failed shocks. We hypothesize that the isoelectric window arises from small-scale shock-induced polarization, such as polarization of trabeculae and papillary muscle. Understanding the isoelectric window mechanisms could pave the way to new strategies for extending it indefinitely, and thus converting a failed shock into a successful one." }, "begin_planned": "2006-11-01T01:00:00+01:00", "begin_effective": "2006-10-18T02:00:00+02:00", "end_planned": "2009-01-31T01:00:00+01:00", "end_effective": "2009-01-17T01:00:00+01:00", "assignment": "2006-10-11T11:51:03+02:00", "program": 21, "subprogram": "Marie Curie (Outgoing International Fellowship)", "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 50966, "contact": 50966, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "917-50966-10", "917-51502-12" ] }, { "id": 287, "title": { "de": "PEROXISOMES: Integrated Project to decipher the biological function of peroxisomes in health and disease", "en": "PEROXISOMES: Integrated Project to decipher the biological function of peroxisomes in health and disease" }, "short": "Peroxisomes", "url": null, "abstract": { "de": "Although peroxisomes are essential for life, the various functions and dynamics of this organelle in health and disease are only poorly understood. Most inherited peroxisomal disorders in humans have a low incidence but collectively they represent an enormous burden on affected individuals, families and society. A detailed understanding of biogenesis and function of this organelle is required for developing therapeutic strategies. To bridge the gap between the scarce knowledge about peroxisomes and their importance for living organisms, we will establish genomic, proteomic and metabolomic platforms focussed on peroxisomes. We will identify novel peroxisomal matrix and membrane proteins and gather comprehensive knowledge about their functions. Using this information, we should be able to decipher the molecular mechanism of so far uncharacterised peroxisomal disorders and open up novel diagnostic and therapeutic opportunities. Genome-wide gene expression and biochemical analyses of 14 different mouse models of peroxisomal deficiencies will reveal why differing phenotypes occur even when the same metabolic pathway is disturbed. Mouse genetics will be used to evaluate the role of peroxisomes in different cell types during development and in adulthood. Because evidence is emerging for a role of peroxisomes as modulators in diseases of complex inheritance, such as arteriosclerosis, cancer and Alzheimer's disease, we will screen appropriate databases to detect dysregulation of genes encoding peroxisomal proteins. Tissue microarray analysis, cDNA chip and quantitative RT-PCR analysis will be used to verify the results with the final goal to develop diagnostic tools. The role of peroxisomes in Alzheimer's disease and in chronic metabolic liver diseases will be analysed and the biogenesis and dynamics of this organelle deciphered. Only with this integrated EU project will we be able to elucidate the role of peroxisomes in living organisms in the near future.", "en": "Although peroxisomes are essential for life, the various functions and dynamics of this organelle in health and disease are only poorly understood. Most inherited peroxisomal disorders in humans have a low incidence but collectively they represent an enormous burden on affected individuals, families and society. A detailed understanding of biogenesis and function of this organelle is required for developing therapeutic strategies. To bridge the gap between the scarce knowledge about peroxisomes and their importance for living organisms, we will establish genomic, proteomic and metabolomic platforms focussed on peroxisomes. We will identify novel peroxisomal matrix and membrane proteins and gather comprehensive knowledge about their functions. Using this information, we should be able to decipher the molecular mechanism of so far uncharacterised peroxisomal disorders and open up novel diagnostic and therapeutic opportunities. Genome-wide gene expression and biochemical analyses of 14 different mouse models of peroxisomal deficiencies will reveal why differing phenotypes occur even when the same metabolic pathway is disturbed. Mouse genetics will be used to evaluate the role of peroxisomes in different cell types during development and in adulthood. Because evidence is emerging for a role of peroxisomes as modulators in diseases of complex inheritance, such as arteriosclerosis, cancer and Alzheimer's disease, we will screen appropriate databases to detect dysregulation of genes encoding peroxisomal proteins. Tissue microarray analysis, cDNA chip and quantitative RT-PCR analysis will be used to verify the results with the final goal to develop diagnostic tools. The role of peroxisomes in Alzheimer's disease and in chronic metabolic liver diseases will be analysed and the biogenesis and dynamics of this organelle deciphered. Only with this integrated EU project will we be able to elucidate the role of peroxisomes in living organisms in the near future." }, "begin_planned": "2005-01-01T01:00:00+01:00", "begin_effective": "2005-01-01T01:00:00+01:00", "end_planned": "2008-12-31T01:00:00+01:00", "end_effective": "2008-12-31T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 21, "subprogram": "Life sciences, genomics and biotechnology for health", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51691, "contact": 51691, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "287-51691-10" ] }, { "id": 1320, "title": { "de": "Mikrobiologische Untersuchungen in steirischen Weinkellern", "en": "Mikrobiologische Untersuchungen in steirischen Weinkellern" }, "short": "MIKROBIOLOG_STEIR_WEINKELLER", "url": null, "abstract": { "de": "Im geplanten Forschungsprojekt sollte eine erste umfangreiche Evaluierung der steirischen Weinkeller im Hinblick auf das Vorkommen von unerwünschten Mikroorganismen (Schimmelpilzen und Bakterien) durchgeführt werden und die Beeinflussung von Bioaerosolen auf die Weinherstellung untersucht werden.\r\nÜber einen Zetruaum von zwei Jahren sollten dabei in der Steiermark 40 verschiedene Weinkeller (unter Berücksichtigung unterschiedlicher baulicher Parameter) untersucht werden. Anhand von quantitativen und qualitativen Analysen sollte untersucht werden, in welchem Ausmaß Mikroorganismen Kellerräume belasten und in Folge die Qualität des Weines beeinträchtigen könnten. \r\nDie Untersuchungen über die Menge und Zusammenstezung der Mikroflora in Weinkellern sind sowohl für den Weinherstellungsprozess als auch aus Gründen des Arbeitnehmerschutzes von großer Bedeutung.", "en": "Im geplanten Forschungsprojekt sollte eine erste umfangreiche Evaluierung der steirischen Weinkeller im Hinblick auf das Vorkommen von unerwünschten Mikroorganismen (Schimmelpilzen und Bakterien) durchgeführt werden und die Beeinflussung von Bioaerosolen auf die Weinherstellung untersucht werden.\r\nÜber einen Zetruaum von zwei Jahren sollten dabei in der Steiermark 40 verschiedene Weinkeller (unter Berücksichtigung unterschiedlicher baulicher Parameter) untersucht werden. Anhand von quantitativen und qualitativen Analysen sollte untersucht werden, in welchem Ausmaß Mikroorganismen Kellerräume belasten und in Folge die Qualität des Weines beeinträchtigen könnten. \r\nDie Untersuchungen über die Menge und Zusammenstezung der Mikroflora in Weinkellern sind sowohl für den Weinherstellungsprozess als auch aus Gründen des Arbeitnehmerschutzes von großer Bedeutung." }, "begin_planned": "2007-02-01T01:00:00+01:00", "begin_effective": "2006-11-01T01:00:00+01:00", "end_planned": "2008-12-31T01:00:00+01:00", "end_effective": "2008-12-31T01:00:00+01:00", "assignment": "2007-07-03T10:07:42+02:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 51674, "contact": 51674, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1320-51674-10" ] }, { "id": 1469, "title": { "de": "Evaluation of Neuroproteins as Biomarkers for Traumatic Brain Injury in Pediatric Patients", "en": "Evaluation of Neuroproteins as Biomarkers for Traumatic Brain Injury in Pediatric Patients" }, "short": "TRAUMATIC_BRAIN_INJURY", "url": null, "abstract": { "de": "Berichte in der Literatur und eigene Untersuchungen lassen auf einen diagnostischen und ökonomischen Vorteil durch die Bestimmung von Neuroproteinen bei Patienten mit Schädel-Hirn-Trauma schließen. Bisher kann bei einem negativen Testergebnis eine signifikante Läsion mit Sicherheit ausgeschlossen, bei einem positiven aber nicht als bewiesen angesehen werden. Um nähere Erkenntnisse über Funktion und Regulation von S-100B, GFAP, MBP, NSE und CTP zu erhalten, sind Untersuchungen an einem großen pädiatrischen Kollektiv erforderlich. S-100B wurde bereits in einer groß angelegten Untersuchung durch die Antragsteller (n=300)evaluiert. Ziel dieser Untersuchung ist es, die anderen 4 Biomarker im selben Kollektiv zu analysieren. Weiters sollen Normwerte der untersuchten Marker für die kindliche Population anhand eines gesunden Kollektives aufgestellt werden, da diese bisher nur für Erwachsene bestimmt wurden und ein Rückschluss auf Kinder nicht unbedingt möglich ist.", "en": "Berichte in der Literatur und eigene Untersuchungen lassen auf einen diagnostischen und ökonomischen Vorteil durch die Bestimmung von Neuroproteinen bei Patienten mit Schädel-Hirn-Trauma schließen. Bisher kann bei einem negativen Testergebnis eine signifikante Läsion mit Sicherheit ausgeschlossen, bei einem positiven aber nicht als bewiesen angesehen werden. Um nähere Erkenntnisse über Funktion und Regulation von S-100B, GFAP, MBP, NSE und CTP zu erhalten, sind Untersuchungen an einem großen pädiatrischen Kollektiv erforderlich. S-100B wurde bereits in einer groß angelegten Untersuchung durch die Antragsteller (n=300)evaluiert. Ziel dieser Untersuchung ist es, die anderen 4 Biomarker im selben Kollektiv zu analysieren. Weiters sollen Normwerte der untersuchten Marker für die kindliche Population anhand eines gesunden Kollektives aufgestellt werden, da diese bisher nur für Erwachsene bestimmt wurden und ein Rückschluss auf Kinder nicht unbedingt möglich ist." }, "begin_planned": "2008-01-01T01:00:00+01:00", "begin_effective": "2008-01-01T01:00:00+01:00", "end_planned": "2008-12-31T01:00:00+01:00", "end_effective": "2009-06-30T02:00:00+02:00", "assignment": "2008-02-07T17:45:07+01:00", "program": 79, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 50785, "contact": 50785, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1469-50785-10", "1469-51344-11", "1469-58794-11" ] }, { "id": 1748, "title": { "de": "Anbahnungsfinanzierung Healthcare integrated Biobanking RP7 Health 1. Stufe", "en": "Anbahnungsfinanzierung Healthcare integrated Biobanking RP7 Health 1. Stufe" }, "short": "HEALTHCARE_INTEGR_BIOBANKING", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2008-09-03T02:00:00+02:00", "begin_effective": "2008-09-03T02:00:00+02:00", "end_planned": "2008-12-31T01:00:00+01:00", "end_effective": "2008-12-31T01:00:00+01:00", "assignment": "2009-02-17T13:36:04+01:00", "program": 54, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 51663, "contact": 51663, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "821139", "ethics_committee": null, "edudract_number": null, "persons": [ "1748-51663-10" ] }, { "id": 585, "title": { "de": "Charakterisierung von kardiovaskulären TRPC3 Kanälen (Teilprojekt)", "en": "Characterization of cardiovascular TRPC3 channels (Teilprojekt)" }, "short": "Char. of cardiovascular TRPC3 channels", "url": null, "abstract": { "de": "Over the past decade, evidence for a pivotal role of TRP (transient receptor potential) proteins in cellular Ca2+ signaling has accumulated, and the concept of TRP signaling complexes as a potential pharmacological target has emerged. TRPC proteins form cation channel complexes and are considered as highly versatile signal transduction molecules. Results obtained in heterologous expression systems suggest TRPC3 as a paradigm of multifunctional signal transduction. Due to its ability to form signalplexes with a variety of signaling partners, TRPC3 may serve cellular CA2+ signaling by multiple mechanisms and may control a variety of diestinct physiological functions. In the cardiovascular system, TRPC3 is a prominent TRPC species in endothelial cells and cardiac myocytes. The structure, regulation and functional role of cardiovascular TRPC3 channel complexes remain still elusive. Open questions that will be addressed in this project are: i) What are the pore-forming interaction partners of TRPC3 in native cardiovascular TRPC3 channel complexes, and what is the role of specific subunits as determinants of chanel function? ii) What is the physiological significance of interactions between TRPC3 and cardiovascular signaling molecules such as caveolin-1 and NCX1 in terms of channel gating and/or transduction of input stimuli into distinct Ca2+ signals? These topics will be investigated using native macro- and microvascular endothelial cell as well as cardiac myocytes. The employed methods comprise classical techniques for subcellular localization of signaling molecules and for analysis of protein-protein interactions as well as subunit stoichiometry such as immunocytochemistry, immunoprecipitation and GST-pulldown experiments as well as analysis of mutation-induced changes in channel properties. These classical methods will be complemented by detection of protein-protein interactions within TRPC signalplexes with FRET- and single molecule-microscopy and by proteomic aööroaches to identify novel signaling partners of TRPC3. The function of cardiovascular TRPC signalplexes will be analyzed by simultaneous measurement of membrane currents and intracellular ion concentrations. The proposed rigorous analysis of the molecular organization, function and physiological role of cardiovascular TRPC3 channels is suggested as an important step towards exploiting endothelial TRPC proteins as a therapeutic target. ", "en": "Over the past decade, evidence for a pivotal role of TRP (transient receptor potential) proteins in cellular Ca2+ signaling has accumulated, and the concept of TRP signaling complexes as a potential pharmacological target has emerged. TRPC proteins form cation channel complexes and are considered as highly versatile signal transduction molecules. Results obtained in heterologous expression systems suggest TRPC3 as a paradigm of multifunctional signal transduction. Due to its ability to form signalplexes with a variety of signaling partners, TRPC3 may serve cellular CA2+ signaling by multiple mechanisms and may control a variety of diestinct physiological functions. In the cardiovascular system, TRPC3 is a prominent TRPC species in endothelial cells and cardiac myocytes. The structure, regulation and functional role of cardiovascular TRPC3 channel complexes remain still elusive. Open questions that will be addressed in this project are: i) What are the pore-forming interaction partners of TRPC3 in native cardiovascular TRPC3 channel complexes, and what is the role of specific subunits as determinants of chanel function? ii) What is the physiological significance of interactions between TRPC3 and cardiovascular signaling molecules such as caveolin-1 and NCX1 in terms of channel gating and/or transduction of input stimuli into distinct Ca2+ signals? These topics will be investigated using native macro- and microvascular endothelial cell as well as cardiac myocytes. The employed methods comprise classical techniques for subcellular localization of signaling molecules and for analysis of protein-protein interactions as well as subunit stoichiometry such as immunocytochemistry, immunoprecipitation and GST-pulldown experiments as well as analysis of mutation-induced changes in channel properties. These classical methods will be complemented by detection of protein-protein interactions within TRPC signalplexes with FRET- and single molecule-microscopy and by proteomic aööroaches to identify novel signaling partners of TRPC3. The function of cardiovascular TRPC signalplexes will be analyzed by simultaneous measurement of membrane currents and intracellular ion concentrations. The proposed rigorous analysis of the molecular organization, function and physiological role of cardiovascular TRPC3 channels is suggested as an important step towards exploiting endothelial TRPC proteins as a therapeutic target. " }, "begin_planned": "2006-01-01T01:00:00+01:00", "begin_effective": "2006-01-01T01:00:00+01:00", "end_planned": "2008-12-31T01:00:00+01:00", "end_effective": "2008-12-31T01:00:00+01:00", "assignment": "2005-11-14T16:35:00+01:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51705, "contact": 51705, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P18280", "ethics_committee": null, "edudract_number": null, "persons": [ "585-51705-10" ] }, { "id": 999, "title": { "de": "Einfluss vom ET/ET Rezeptor System auf die Apoptose in Plazenten aus normalen und pathologischen Schwangerschaften", "en": "Einfluss vom ET/ET Rezeptor System auf die Apoptose in Plazenten aus normalen und pathologischen Schwangerschaften" }, "short": "APOPTOSE_PLAZENTE", "url": null, "abstract": { "de": "Apoptose ist ein kontrollierter Prozess des natürlichen Zelltods, ein physiologisches und erwünschtes Geschehen. Leider, gibt es viele Krankheiten die mit einer abnormen Apoptose in verschiedenen Organen verbunden oder sogar durch sie verursacht sind. In Schwangerschaften die durch Diabetes, Präeklampsie und fetale Wachstumsretardierung kompliziert sind, wurde eine erhöhte Apoptose in der Plazenta nachgewiesen. Endotheline, besonders Endothelin-1, und ihre Rezeptoren: ETA und ETB, könnten in diesen pathologischen Umständen eine wichtige Rolle spielen. Wegen des starken Einflusses von Endothelin-1 auf Proliferation, Invasion und Apoptose bei Karzinomzellen, verbindet man diese Substanz immer mehr mit ähnlichen Zellprozessen bei Trophoblastzellen.\r\n In der Inneren Medizin versucht man schon erfolgreich dem unerwünschten Effekt der Endotheline mit ihren Rezeptor-Antagonisten vorzubeugen. \r\nDas Ziel dieser Studie ist die physiologische Darstellung der Rolle dieses Systems in der Apoptose der normalen Plazenta, und die Erforschung der Veränderungen des Systems bei den Krankheiten mit erhöhter Apoptose in der Plazenta, wie diabetischen, präeklamptischen Schwangerschaften und Schwangerschaften mit der fetalen Wachstumsretardierung.", "en": "Apoptose ist ein kontrollierter Prozess des natürlichen Zelltods, ein physiologisches und erwünschtes Geschehen. Leider, gibt es viele Krankheiten die mit einer abnormen Apoptose in verschiedenen Organen verbunden oder sogar durch sie verursacht sind. In Schwangerschaften die durch Diabetes, Präeklampsie und fetale Wachstumsretardierung kompliziert sind, wurde eine erhöhte Apoptose in der Plazenta nachgewiesen. Endotheline, besonders Endothelin-1, und ihre Rezeptoren: ETA und ETB, könnten in diesen pathologischen Umständen eine wichtige Rolle spielen. Wegen des starken Einflusses von Endothelin-1 auf Proliferation, Invasion und Apoptose bei Karzinomzellen, verbindet man diese Substanz immer mehr mit ähnlichen Zellprozessen bei Trophoblastzellen.\r\n In der Inneren Medizin versucht man schon erfolgreich dem unerwünschten Effekt der Endotheline mit ihren Rezeptor-Antagonisten vorzubeugen. \r\nDas Ziel dieser Studie ist die physiologische Darstellung der Rolle dieses Systems in der Apoptose der normalen Plazenta, und die Erforschung der Veränderungen des Systems bei den Krankheiten mit erhöhter Apoptose in der Plazenta, wie diabetischen, präeklamptischen Schwangerschaften und Schwangerschaften mit der fetalen Wachstumsretardierung." }, "begin_planned": "2007-01-01T01:00:00+01:00", "begin_effective": "2007-01-01T01:00:00+01:00", "end_planned": "2008-12-31T01:00:00+01:00", "end_effective": "2009-12-31T01:00:00+01:00", "assignment": "2007-01-15T14:20:10+01:00", "program": null, "subprogram": null, "organization": 14064, "category": 10, "type": 10, "partner_function": 4, "manager": 51978, "contact": 51978, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "999-51978-10" ] }, { "id": 1506, "title": { "de": "PRIVILEGED", "en": "PRIVILEGED" }, "short": "PRIVILEGED", "url": null, "abstract": { "de": "PRIVILEGED (Privacy in Law, Ethics and Genetic Data) will make recommendations for research practice and public policy-making, including regulatory options at the national and European level, to promote the optimal relation between research using genetic data and bio-banks and ethical interests in privacy. PRIVILEGED will identify, analyse and compare plural ethical, cultural and social concepts of legitimate privacy interest engaged by research using genetic database and bio-banks. It will articulate the relation between such concepts and the current regulation of research using genetic data and bio-banks.\r\nPRIVILEGED will bring together experts in medicine, public health, philosophy, ethics, sience and law from across the whole research area. A series of workshops, web-resources, national and comparaive papers will be co-ordinated through three centres (Lthuania, Portugal and the UK) to address points of both potential conflict and synergy within and between the interests of science and privacy, individual and groups, and diverse cultures and fundamental ethical principles.", "en": "PRIVILEGED (Privacy in Law, Ethics and Genetic Data) will make recommendations for research practice and public policy-making, including regulatory options at the national and European level, to promote the optimal relation between research using genetic data and bio-banks and ethical interests in privacy. PRIVILEGED will identify, analyse and compare plural ethical, cultural and social concepts of legitimate privacy interest engaged by research using genetic database and bio-banks. It will articulate the relation between such concepts and the current regulation of research using genetic data and bio-banks.\r\nPRIVILEGED will bring together experts in medicine, public health, philosophy, ethics, sience and law from across the whole research area. A series of workshops, web-resources, national and comparaive papers will be co-ordinated through three centres (Lthuania, Portugal and the UK) to address points of both potential conflict and synergy within and between the interests of science and privacy, individual and groups, and diverse cultures and fundamental ethical principles." }, "begin_planned": "2006-01-01T01:00:00+01:00", "begin_effective": "2006-01-01T01:00:00+01:00", "end_planned": "2008-12-31T01:00:00+01:00", "end_effective": "2008-12-31T01:00:00+01:00", "assignment": "2008-04-03T17:43:24+02:00", "program": 21, "subprogram": null, "organization": 14045, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1004, "title": { "de": "Genetische Risikofaktoren von Plattenepithelkarzinomen und Plattenepithelpräkanzerosen des oberen Respiration- und Digestionstraktes", "en": "Genetische Risikofaktoren von Plattenepithelkarzinomen und Plattenepithelpräkanzerosen des oberen Respiration- und Digestionstraktes" }, "short": "GEN_PLATTENEPITHEL", "url": null, "abstract": { "de": "Die weitaus häufigste Form bösartiger Neubildungen im HNO-Bereich stellt unabhängig von der anatomischen Lage mit über 90% das Plattenepithelkarzinom dar. Bisherige Diagnose- und Therapieverfahren stoßen durch die enorme Heterogenität, sowohl der Entstehung, als auch des weiteren Verlaufes maligner Erkrankungen an ihre Grenzen.\r\nZiel der Studie ist der Aufbau einer DNA- und Serumbank mit dem Ziel der Charakterisierung molekularer Polymorphismen und Blutparameter, die mit der Entstehung und der Tumorbiologie oraler Plattenepithelkarzinome und deren Vorläufern in Verbindung stehen. Des weiteren die Beschreibung neuer genetischer Varianten, die einen Zusammenhang mit der beschrebenen Neoplasie aufweisen.", "en": "Die weitaus häufigste Form bösartiger Neubildungen im HNO-Bereich stellt unabhängig von der anatomischen Lage mit über 90% das Plattenepithelkarzinom dar. Bisherige Diagnose- und Therapieverfahren stoßen durch die enorme Heterogenität, sowohl der Entstehung, als auch des weiteren Verlaufes maligner Erkrankungen an ihre Grenzen.\r\nZiel der Studie ist der Aufbau einer DNA- und Serumbank mit dem Ziel der Charakterisierung molekularer Polymorphismen und Blutparameter, die mit der Entstehung und der Tumorbiologie oraler Plattenepithelkarzinome und deren Vorläufern in Verbindung stehen. Des weiteren die Beschreibung neuer genetischer Varianten, die einen Zusammenhang mit der beschrebenen Neoplasie aufweisen." }, "begin_planned": "2006-01-01T01:00:00+01:00", "begin_effective": "2006-07-01T02:00:00+02:00", "end_planned": "2008-12-31T01:00:00+01:00", "end_effective": "2008-12-31T01:00:00+01:00", "assignment": "2007-01-15T14:23:09+01:00", "program": null, "subprogram": null, "organization": 14068, "category": 10, "type": 10, "partner_function": 4, "manager": 50670, "contact": 50670, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1004-50670-10" ] }, { "id": 1435, "title": { "de": "STYJOBS - Interventionsoptimierung", "en": "STYJOBS - Interventionsoptimierung" }, "short": "STYJOBS_INTERVENT", "url": null, "abstract": { "de": "Das Projekt STYJOBS (STYrian Juvenile OBesity Study) befasst sich mit der Prävention und Theragnostik von Atherosklerose und Adipositas assoziierten Folgeerkrankungen. Aufbauend auf den bisher durchgeführten Arbeiten soll STYJOBS zu einem besseren Verständnis des Zusammenhanges zwischen Adipositas, Ess-Sucht, Entzündungsreaktionen, oxidativem Stress, genetischer Disposition, Atherosklerose und den assoziierten metabolischen Veränderungen (z.B.:Typ 2 Diabetes mellitus) führen. Dies ist eine unabdingbare Voraussetzung für eine effiziente Vorbeugung von Herzinfarkt und Schlaganfall, den häufigsten Todesursachen in unserem Bundesland.\r\nEin integraler Bestandteil von STYJOBS ist die Durchführung und Verbesserung von Interventionsmaßnahmen bei Adipositas. Aufbauend auf eine im Jahr 2006 durchgeführte umfassend evaluierte Erstintervention wird derzeit eine weitere Intervention unter besonderer Addressierung des Suchtfaktors durchgeführt. Dabei werden unter anderem neue objektive Wege der bildgebenden noninvasiven Diagnostik von dopaminergen Regelkreisen zur Kontrolle des Sättigungsverhaltens beschritten. Mit den solcherart gewonnenen Erkenntnissen soll primär sucht-disponierten adipösen jungen Menschen in Zukunft effektiver geholfen werden.", "en": "Das Projekt STYJOBS (STYrian Juvenile OBesity Study) befasst sich mit der Prävention und Theragnostik von Atherosklerose und Adipositas assoziierten Folgeerkrankungen. Aufbauend auf den bisher durchgeführten Arbeiten soll STYJOBS zu einem besseren Verständnis des Zusammenhanges zwischen Adipositas, Ess-Sucht, Entzündungsreaktionen, oxidativem Stress, genetischer Disposition, Atherosklerose und den assoziierten metabolischen Veränderungen (z.B.:Typ 2 Diabetes mellitus) führen. Dies ist eine unabdingbare Voraussetzung für eine effiziente Vorbeugung von Herzinfarkt und Schlaganfall, den häufigsten Todesursachen in unserem Bundesland.\r\nEin integraler Bestandteil von STYJOBS ist die Durchführung und Verbesserung von Interventionsmaßnahmen bei Adipositas. Aufbauend auf eine im Jahr 2006 durchgeführte umfassend evaluierte Erstintervention wird derzeit eine weitere Intervention unter besonderer Addressierung des Suchtfaktors durchgeführt. Dabei werden unter anderem neue objektive Wege der bildgebenden noninvasiven Diagnostik von dopaminergen Regelkreisen zur Kontrolle des Sättigungsverhaltens beschritten. Mit den solcherart gewonnenen Erkenntnissen soll primär sucht-disponierten adipösen jungen Menschen in Zukunft effektiver geholfen werden." }, "begin_planned": "2007-05-01T02:00:00+02:00", "begin_effective": "2007-05-01T02:00:00+02:00", "end_planned": "2008-12-31T01:00:00+01:00", "end_effective": "2008-12-31T01:00:00+01:00", "assignment": "2008-01-07T13:23:48+01:00", "program": null, "subprogram": null, "organization": 14028, "category": 10, "type": 10, "partner_function": 4, "manager": 52854, "contact": 52854, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1435-52854-10" ] }, { "id": 1313, "title": { "de": "GENOPTIKUM", "en": "GENOPTIKUM" }, "short": "GENOPTIKUM", "url": null, "abstract": { "de": "GENOPTIKUM is an interactive data exploration system for the \"visualization of\" and \" navigation in\" molecular and clinical data in the field of personalized medicine. GENOPTIKUM addresses the essential but to date unsolved problem of how to identify connections between genetic variants and their corresponding diseases or the response to certain drugs and treatments, respectively. It is, therefore, necessary to connect gene data and clinical data in order to categorise specific subgroups of patients with certain disease features. The huge amount of data provided by molecular analytical methods (genetic polymorphisms, gene expression data, proteomics) can only be analysed by applying statistical methods and bioinformatics. However, even standard methods of statistics and bioinformatics fail when the data are inhomogeneous - as is the case with clinical data - and when data structures are obscured by noise and dominant patterns", "en": "GENOPTIKUM is an interactive data exploration system for the \"visualization of\" and \" navigation in\" molecular and clinical data in the field of personalized medicine. GENOPTIKUM addresses the essential but to date unsolved problem of how to identify connections between genetic variants and their corresponding diseases or the response to certain drugs and treatments, respectively. It is, therefore, necessary to connect gene data and clinical data in order to categorise specific subgroups of patients with certain disease features. The huge amount of data provided by molecular analytical methods (genetic polymorphisms, gene expression data, proteomics) can only be analysed by applying statistical methods and bioinformatics. However, even standard methods of statistics and bioinformatics fail when the data are inhomogeneous - as is the case with clinical data - and when data structures are obscured by noise and dominant patterns" }, "begin_planned": "2007-01-01T01:00:00+01:00", "begin_effective": "2007-08-01T02:00:00+02:00", "end_planned": "2008-12-31T01:00:00+01:00", "end_effective": "2010-04-30T02:00:00+02:00", "assignment": "2007-06-26T15:39:42+02:00", "program": null, "subprogram": "FFG-Programm: FIT-IT 5% des Gesamtprojektvolumens wird von der Fa. Oridis in CASH an Unis bezahlt.", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": 51663, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1313-51449-12", "1313-51663-10" ] } ] }