Project List

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            "id": 8765,
            "title": {
                "de": "Einfluss der perioperativen probiotischen Therapie auf Regeneration und klinische Ergebnisse bei zweizeitiger Major-Hepatektomie – eine prospektive randomisiert-kontrollierte Studie",
                "en": "Impact of perioperative probiotic therapy on regeneration and clinical outcomes in\r\ntwo-stage major hepatectomy – a prospective randomized controlled study"
            },
            "short": "PROTECT_HEPATECTOMY Studie",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
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            "organization": 14073,
            "category": 10,
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            "status": 2,
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                3833
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                "8765-117782-10"
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        {
            "id": 9066,
            "title": {
                "de": "Effekt von Boswellia serrata auf Schmerzintensität, zentrale und periphere Sensibilisierung, Schmerzmodulation bei gesunden Proband:innen - eine randomisierte, doppelblinde, placebo-kontrollierte, cross-over Pilot-Prüfung\r\n",
                "en": "Effect of Boswellia serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Subjects – A Randomized, Double-Blind, Placebo-Controlled, Crossover Pilot Trial"
            },
            "short": null,
            "url": null,
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                "de": null,
                "en": null
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            "end_planned": "2026-03-01T01:00:00+01:00",
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            "assignment": "2025-07-02T16:14:25+02:00",
            "program": null,
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            "organization": 14069,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 101248,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
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            "funders": [
                2471
            ],
            "funder_projectcode": null,
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            "persons": [
                "9066-101248-10"
            ]
        },
        {
            "id": 9270,
            "title": {
                "de": "Strukturiertes Kommunikationstraining mit standardisierten Patient*innen für die antenatale neonatologische Beratung bei drohender Frühgeburt",
                "en": "Antenatal Counselling Training for expected preterm delivery using structured communication training with standardized patients"
            },
            "short": "ACT",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-10-01T02:00:00+02:00",
            "begin_effective": "2025-10-01T02:00:00+02:00",
            "end_planned": "2026-12-31T01:00:00+01:00",
            "end_effective": "2026-12-31T01:00:00+01:00",
            "assignment": "2025-10-15T18:28:23+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14094,
            "category": 10,
            "type": 10,
            "partner_function": 1,
            "manager": 68534,
            "contact": null,
            "status": 2,
            "research": 10,
            "grant": 10,
            "event": null,
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            "language": null,
            "funders": [
                97
            ],
            "funder_projectcode": null,
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            "persons": [
                "9270-68534-10"
            ]
        },
        {
            "id": 9223,
            "title": {
                "de": "Diethylsuccinat als neues Therapeutikum bei IPF",
                "en": "Diethylsuccinate as a novel therapeutic for IPF"
            },
            "short": "Diethylsuccinat_therapeutic_IPF",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-10-01T02:00:00+02:00",
            "begin_effective": "2025-11-01T01:00:00+01:00",
            "end_planned": "2028-09-30T02:00:00+02:00",
            "end_effective": "2029-10-31T01:00:00+01:00",
            "assignment": "2025-09-24T11:54:15+02:00",
            "program": 72,
            "subprogram": null,
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 85658,
            "contact": null,
            "status": 2,
            "research": 1,
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                9
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            "funder_projectcode": "PAT2165825",
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            "persons": [
                "9223-85658-10",
                "9223-50132-12",
                "9223-111587-12",
                "9223-116746-12",
                "9223-126994-12"
            ]
        },
        {
            "id": 9279,
            "title": {
                "de": "Verständnis und Kontrolle von Methanobrevibacter zum Nutzen von Umwelt und Gesundheit",
                "en": "Archaeal keystone species in host microbiomes:\r\nUnderstanding and controlling Methanobrevibacter for Environmental and Health Benefits"
            },
            "short": "ARCH-Meth",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-10-01T02:00:00+02:00",
            "begin_effective": "2026-01-01T01:00:00+01:00",
            "end_planned": "2030-09-30T02:00:00+02:00",
            "end_effective": "2030-12-31T01:00:00+01:00",
            "assignment": "2025-10-30T09:03:41+01:00",
            "program": 208,
            "subprogram": null,
            "organization": 14023,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 90021,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
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            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": "101199346",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "9279-90021-10"
            ]
        },
        {
            "id": 9299,
            "title": {
                "de": "Prädiktive Marker und Pathomechanismen der Krankheitsprogression bei Mycosis fungoides",
                "en": "Predictive markers and pathomechanisms of mycosis fungoides disease progression: Integrating Spatial Transcriptomics and In Situ Analysis of archived FFPE samples"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-10-01T02:00:00+02:00",
            "begin_effective": "2025-10-01T02:00:00+02:00",
            "end_planned": "2027-12-31T01:00:00+01:00",
            "end_effective": "2027-09-30T02:00:00+02:00",
            "assignment": "2025-11-06T09:08:00+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14047,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 118468,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1161
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "9299-118468-10"
            ]
        },
        {
            "id": 9130,
            "title": {
                "de": "Auf dem Weg zu einem umfassenden Atlas des menschlichen Atmungsmikrobioms: Taxonomische, genomische und funktionelle Perspektiven",
                "en": "Towards a Comprehensive Atlas of the Human Respiratory Microbiome: Taxonomic,\r\nGenomic, and Functional Perspectives"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-10-01T02:00:00+02:00",
            "begin_effective": "2025-08-01T02:00:00+02:00",
            "end_planned": "2025-01-01T01:00:00+01:00",
            "end_effective": "2026-07-31T02:00:00+02:00",
            "assignment": "2025-08-05T13:14:59+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14023,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 90021,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "9130-90021-10"
            ]
        },
        {
            "id": 9169,
            "title": {
                "de": "Multi-Omics für personalisierte Onkologie im molekularen Tumorboard",
                "en": "Multi-omics for personalized oncology at the Molecular Tumor Board"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-10-01T02:00:00+02:00",
            "begin_effective": "2025-10-01T02:00:00+02:00",
            "end_planned": "2026-10-01T02:00:00+02:00",
            "end_effective": "2026-09-30T02:00:00+02:00",
            "assignment": "2025-08-21T13:31:06+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14085,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 77970,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "9169-77970-10"
            ]
        },
        {
            "id": 9139,
            "title": {
                "de": "HER2-gerichteter M13-Bakteriophage als Träger für TRAIL zur gezielten Therapie von Brustkrebs",
                "en": "Targeted TRAIL delivery via HER2-specific M13 bacteriophage for breast cancer therapy"
            },
            "short": "PHANTHER",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-10-01T02:00:00+02:00",
            "begin_effective": "2025-10-01T02:00:00+02:00",
            "end_planned": "2027-09-30T02:00:00+02:00",
            "end_effective": "2027-09-30T02:00:00+02:00",
            "assignment": "2025-08-07T12:17:54+02:00",
            "program": 203,
            "subprogram": null,
            "organization": 14012,
            "category": 10,
            "type": 10,
            "partner_function": 1,
            "manager": 124253,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                20
            ],
            "funder_projectcode": "ASEA 29/2025",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "9139-124253-10"
            ]
        },
        {
            "id": 9044,
            "title": {
                "de": "OSIP: Die Erneuerung der Werkzeuge für den Planetenschutz",
                "en": "OSIP: Modernizing planetary protection toolkits"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": "Artikel IX des Weltraumvertrags (OST) (https://www.unoosa.org/oosa/en/ourwork/spacelaw/treaties/outerspacetreaty.html) verlangt, dass die Vertragsstaaten geeignete Maßnahmen ergreifen, um eine schädliche Verunreinigung von Himmelskörpern und nachteilige Veränderungen auf der Erde zu vermeiden. Die ESA handelt im Namen ihrer Mitgliedstaaten, die alle Vertragsparteien des Weltraumvertrags sind. Als solche müssen die Aktivitäten der ESA mit den Verpflichtungen der Mitgliedstaaten gemäß Artikel IX übereinstimmen. Die derzeitigen PP-Standards, die auf den Methoden der Viking-Mission der NASA aus den 1970er Jahren beruhen, sind veraltet. Unser Verständnis von mikrobiellem Leben hat sich weiterentwickelt, und so muss auch unser Ansatz für PP. Wir schlagen ein revolutionäres Projekt im Einklang mit der PP-Vision der ESA für 2026 vor (ESA-TECQI-TN-2024-000152). Unser Ziel ist es, den Standardtest (ECSS-Q-ST-70-55) mit einem hochmodernen probabilistischen Risikobewertungsmodell zu erweitern. Jüngste Forschungsarbeiten (Green et al., 2023) haben mehrere Wissenslücken aufgedeckt, wie z. B. die Überlebensfähigkeit von PP-relevanten Mikroorganismen, die wir nun systematisch angehen wollen. Zu diesem Zweck werden wir modernste Metagenomik als Schlüsseltechnologie zur Bewertung der Biodiversität und des Risikos von Vorwärts- und Rückwärtskontaminationen einsetzen. Durch die Integration von Echtzeit-Sequenzierungstechnologien wie Nanopore können wir zeitnah (<24h) ein Profil von Umgebungen mit geringer Biomasse erstellen und den Ingenieuren ermöglichen, Maßnahmen zu ergreifen. Um die Anpassung von Mikroben an Reinraum- und Raumfahrzeugumgebungen wirklich zu verstehen, werden wir Metabolitenvorhersagen auf Genomebene und Massenspektrometrie von Proteinen und Metaboliten durchführen. Wir planen die Entwicklung eines überwachten maschinellen Lernmodells, das metagenomische und massenspektrometrische Daten nutzt, um einen risikoinformierten Wert für die Überlebensfähigkeit von Mikroben in Reinräumen und auf Oberflächen von Raumfahrzeugen zu ermitteln. Unser innovativer Ansatz wird die PP-Toolkits modernisieren, den ESA-Missionsteams mehr Flexibilität und Effizienz bei der Implementierung von PP in Industrieunternehmen bieten und gleichzeitig die Unternehmensverpflichtungen der ESA zur Durchführung verantwortungsvoller und nachhaltiger Weltraumerkundungen erfüllen. Begleiten Sie uns auf diesem kühnen Weg, PP neu zu definieren und eine sichere und nachhaltige Zukunft in der Weltraumforschung zu gewährleisten.",
                "en": "Article IX of the Outer Space Treaty (OST) (https://www.unoosa.org/oosa/en/ourwork/spacelaw/treaties/outerspacetreaty.html) requires that State parties adopt appropriate measures to avoid harmful contamination of celestial bodies and adverse changes on Earth. ESA acts on behalf of its Member States, all of which are State parties to the OST. As such, ESA's activities shall comply with Member States' obligations to Article IX. The current PP standards, rooted in methodologies from the 1970s NASA Viking mission, are outdated. Our understanding of microbial life has evolved, and so must our approach to PP. We propose a revolutionary project in line with ESA’s PP vision for 2026 (ESA-TECQI-TN-2024-000152). Our goal is to enhance the standard assay (ECSS-Q-ST-70-55) with a cutting-edge probabilistic risk assessment model. Recent research (Green et al., 2023) has unveiled several knowledge gaps, such as the survivability of PP-relevant microorganisms, which we aim to address now systematically. For this, we will leverage state-of-the-art metagenomics as a key technology to assess biodiversity and the risk of forward and backward contaminations. By integrating real-time sequencing technologies like Nanopore, we can profile low biomass environments in a timely manner (<24h) and allow engineers to take action. To truly understand the adaptation of microbes to cleanroom and spacecraft environments, we will implement genome-scale metabolite predictions and mass spectrometry of proteins and metabolites. We plan to develop a supervised machine learning model that uses metagenomic and mass spectrometry data to provide a risk-informed value for the survivability of microbes from cleanrooms and spacecraft surfaces. Our innovative approach will modernize PP toolkits, provide more flexibility and increased efficiency to ESA mission teams when implementing PP inside industrial organizations while fulfilling ESA’s corporate obligations to conduct responsible and sustainable space explorations. Join us in this bold journey to redefine PP and ensure a safe and sustainable future in space exploration."
            },
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            "end_effective": "2028-09-30T02:00:00+02:00",
            "assignment": "2025-06-20T11:55:25+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14023,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 100035,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
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                1203
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            "funder_projectcode": null,
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            "persons": [
                "9044-90021-12",
                "9044-100035-10",
                "9044-113714-12"
            ]
        },
        {
            "id": 9208,
            "title": {
                "de": "Entwicklung von PNPLA3 Inhibitoren",
                "en": "Targeting PNPLA3 activity to elucidate its role in MASLD"
            },
            "short": "PNPLA3 Inhibitoren",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-10-01T02:00:00+02:00",
            "begin_effective": "2026-01-01T01:00:00+01:00",
            "end_planned": "2030-09-30T02:00:00+02:00",
            "end_effective": "2030-12-31T01:00:00+01:00",
            "assignment": "2025-09-18T13:18:49+02:00",
            "program": 250,
            "subprogram": null,
            "organization": 14013,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 124190,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "AST7750924",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "9208-124190-10"
            ]
        },
        {
            "id": 9268,
            "title": {
                "de": "Cross Regions 4 Health",
                "en": "Cross Regions 4 Health"
            },
            "short": "CrossReg-4-Health",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-10-01T02:00:00+02:00",
            "begin_effective": "2025-11-01T01:00:00+01:00",
            "end_planned": "2028-09-30T02:00:00+02:00",
            "end_effective": "2028-10-30T01:00:00+01:00",
            "assignment": "2025-10-13T12:38:35+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14051,
            "category": 10,
            "type": 10,
            "partner_function": 1,
            "manager": 82411,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
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                10
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "9268-82411-10"
            ]
        },
        {
            "id": 9082,
            "title": {
                "de": "Der Einfluss von humanen p53 Varianten auf Gewichtsschwankungs-assoziierte Metaflammation",
                "en": "Impact of human p53 variants on metaflammation during weight cycling"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-09-01T02:00:00+02:00",
            "begin_effective": "2025-09-01T02:00:00+02:00",
            "end_planned": "2028-08-31T02:00:00+02:00",
            "end_effective": "2028-08-31T02:00:00+02:00",
            "assignment": "2025-07-09T15:54:23+02:00",
            "program": 116,
            "subprogram": null,
            "organization": 14017,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 124455,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
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                15
            ],
            "funder_projectcode": null,
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            "edudract_number": null,
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                "9082-124455-10"
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        },
        {
            "id": 9083,
            "title": {
                "de": "Metabolische Signaturen und Reaktionsvorhersage unter Nährstoffentzug bei Brustkrebs",
                "en": "Metabolic Signatures and Response Prediction under Nutrient Deprivation in Breast Cancer"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
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            "end_effective": "2028-08-31T02:00:00+02:00",
            "assignment": "2025-07-09T16:52:51+02:00",
            "program": 116,
            "subprogram": null,
            "organization": 14017,
            "category": 10,
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            "partner_function": 4,
            "manager": 107135,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                15
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "9083-107135-10"
            ]
        },
        {
            "id": 9255,
            "title": {
                "de": "Präziseres Therapiemonitoring dank blutbasierter Biomarker",
                "en": "It’s in our blood: Improving cancer treatment monitoring via liquid biomarkers"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2025-09-01T02:00:00+02:00",
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