Project List

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    "results": [
        {
            "id": 2192,
            "title": {
                "de": "Akupressur-Stimulationsequipment zur emotionalen Entlastung von Menschen mit geistiger Behinderung",
                "en": "Akupressur-Stimulationsequipment zur emotionalen Entlastung von Menschen mit geistiger Behinderung"
            },
            "short": "AKUPRESSUR_STIMULATION",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2013-12-31T01:00:00+01:00",
            "assignment": "2010-05-03T14:28:49+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14044,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51073,
            "contact": 51073,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2192-51073-10"
            ]
        },
        {
            "id": 2043,
            "title": {
                "de": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action",
                "en": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action"
            },
            "short": "ORPHAN RECEPTOR GPR55",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-01-20T12:45:29+01:00",
            "program": 92,
            "subprogram": null,
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                20
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2342,
            "title": {
                "de": "Quantifizierung der orthostatischen Kapazität",
                "en": "Orthocap - Use of galanin and adrenomedullin responses to quantify orthostatic capacity"
            },
            "short": "Orthocap",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2009-07-31T02:00:00+02:00",
            "begin_effective": "2010-12-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2012-12-31T01:00:00+01:00",
            "assignment": "2010-11-22T12:56:50+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51683,
            "contact": 51683,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                416
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2342-51683-10"
            ]
        },
        {
            "id": 2498,
            "title": {
                "de": "Die Rolle von Metalloproteasen und Endothelin im ersten Schwangerschaftstrimester",
                "en": "The role of metalloproteinases and endothelin in the first trimester of pregnancy"
            },
            "short": "METALLPROTEINASES_ENDOTHELIN_PREGNANCY",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-07-01T02:00:00+02:00",
            "begin_effective": "2011-07-01T02:00:00+02:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2011-06-16T12:49:53+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14038,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2095,
            "title": {
                "de": "Purkinje Topology",
                "en": "Purkinje Topology"
            },
            "short": "PURKINJE TOPOLOGY",
            "url": null,
            "abstract": {
                "de": "Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. ",
                "en": "Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. "
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-02-09T12:53:47+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50967,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                894
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2095-50967-10"
            ]
        },
        {
            "id": 2130,
            "title": {
                "de": "Kinder erzählen: Text- und Erzählkompetenz im Vorschulalter: eine Voraussetzung für den schulischen Erfolg.",
                "en": "Narratives in first language acquisition."
            },
            "short": "TEXT- UND ERZÄHLKOMPETENZ",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-03-01T01:00:00+01:00",
            "begin_effective": "2010-03-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-02-24T10:55:39+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 58883,
            "contact": 58883,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2130-58883-10"
            ]
        },
        {
            "id": 2495,
            "title": {
                "de": "Bipolar affektive Erkrankung und Schwangerschaft, Geburt und Postpartum",
                "en": "Bipolar affektive Erkrankung und Schwangerschaft, Geburt und Postpartum"
            },
            "short": "Bipolar affektive Erkrankungen",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-05-01T02:00:00+02:00",
            "begin_effective": "2011-06-01T02:00:00+02:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2012-02-28T01:00:00+01:00",
            "assignment": "2011-06-10T12:18:59+02:00",
            "program": null,
            "subprogram": null,
            "organization": 29444,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50654,
            "contact": 50654,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2495-50654-10"
            ]
        },
        {
            "id": 2090,
            "title": {
                "de": "Expression profiling in hypoxic non-small cell lung cancer",
                "en": "Expression profiling in hypoxic non-small cell lung cancer"
            },
            "short": "NON-SMALL CELL LUNG CANCER ",
            "url": null,
            "abstract": {
                "de": "Das Bronchialkarzinom ist nach wie vor die führende Krebstodesursache weltweit. 80% sind sogenannte Nicht-kleinzellige Bronchialkarzinome (non-small cell lung cancers, NSCLC). Das Gesamtüberleben der Patienten mit NSCLC ist schlecht, trotz der derzeit vorhandenen Therapieoptionen, zum Teil wegen Resistenz gegenüber Radio- und Chemotherapie. Tumorhypoxie (verminderte Sauerstoffzufuhr im Tumor) induziert in den Tumorzellen Adaptationsvorgänge und ist zum Teil für die Therapieresistenz verantwortlich. Die genauen Mechanismen sind jedoch nicht bekannt. Unser neu etabliertes ex-vivo Modell der hypoxischen Adaptation beim NSCLC, welches auf der Verwendung von kleinsten NSCLC Fragmenten aus Operationsmaterial beruht, ist geignet, um die Vorgänge im Tumor unter hypoxischen Bedingungen zu untersuchen. Das Ziel der vorliegenden Studie ist, die Genexpressionsmuster der in Hypoxie bzw unter normalen Sauerstoffbedingungen kultivierten NSCLC Fragmente zu vergleichen. Die differenziell regulierten Gene werden dafür mittels cDNA microarrays bestimmt. Die Ergebnisse werden in nachfolgenden Einzelgen-Polymerase Kettenreaktionen validiert. Unsere Studie könnte somit das Verständnis der Pathomechanismen beim Tumorwachstum verbessern und mögliche neue Therapieoptionen beim NSCLC aufzeigen.",
                "en": "Lung cancer is the leading cause of cancer deaths overall in the world. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancers. Overall survival is poor, in part due to resistance to chemotherapy and radiotherapy. Intratumoral hypoxia (limited oxygen supply) frequently occurs in solid tumors, such as NSCLC. Hypoxia initiates adaptive responses in tumor cells and was shown to induce chemotherapy resistance and promote aggressive tumor growth. The mechanisms of hypoxia-induced adaptive responses in solid tumors are not fully elucidated, yet. We established an ex-vivo model for hypoxic adaptation using NSCLC surgery fragments. The fragments are maintained in short-time culture in hypoxia or ambient oxygen (normoxia) without significant loss of viability or increase in apoptosis and display significant induction of carbonic anhydrase IX, a marker for tumor hypoxia, under hypoxic conditions. The aim of the current study is to analyze hypoxia-induced gene expression changes using cDNA microarrays and consecutive single gene real-time polymerase chain reaction (RT-PCR) on hypoxic vs. normoxic NSCLC fragments, in order to identify genes that are consistently induced or suppressed in hypoxia.  Our study thus provides a novel approach to identify molecular pathways that are crucial for hypoxic adaptive changes in NSCLC and might represent targets for therapy."
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-02-09T11:39:13+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14087,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 57557,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                894
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2090-57557-10"
            ]
        },
        {
            "id": 2340,
            "title": {
                "de": "Die Bedeutung des gluconeogenetischen Enzyms Phosphoenolpyruvat Carboxykinase (PEPCK) für das Tumorwachstum",
                "en": "The role of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) in cancer growth"
            },
            "short": "PEPCK",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-09-01T02:00:00+02:00",
            "begin_effective": "2010-12-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2012-03-31T02:00:00+02:00",
            "assignment": "2010-11-17T10:58:29+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14087,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 57557,
            "contact": 57557,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2340-57557-10"
            ]
        },
        {
            "id": 2339,
            "title": {
                "de": "Proteomic and microbial profiling of human cervico-vaginal fluid and saliva of pregnant women throughout gestation",
                "en": "Proteomic and microbial profiling of human cervico-vaginal fluid and saliva of pregnant women throughout gestation"
            },
            "short": "PROTEOMIC PROFILING",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-07-01T02:00:00+02:00",
            "begin_effective": "2011-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2012-12-31T01:00:00+01:00",
            "assignment": "2010-11-11T13:26:31+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14064,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51719,
            "contact": 51719,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2339-51719-10"
            ]
        },
        {
            "id": 2097,
            "title": {
                "de": "Role of SPN in PP1-mediated RyR2 regulation and intracellular Ca2+ handling",
                "en": "Role of SPN in PP1-mediated RyR2 regulation and intracellular Ca2+ handling"
            },
            "short": "ROLE OF SPN ",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-02-09T12:56:38+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                894
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2550,
            "title": {
                "de": "Endothelin und Matrixmetalloproteinasen im ersten Schwangerschaftstrimester",
                "en": "Endothelin and matrix metalloproteinases in the first trimester of pregnancy"
            },
            "short": "EndothelMatrix",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-08-01T02:00:00+02:00",
            "begin_effective": "2011-08-01T02:00:00+02:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2011-08-02T14:12:12+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14038,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2457,
            "title": {
                "de": "INTEROCEPTION AND ARTERIAL STIFFNESS",
                "en": "INTEROCEPTION AND ARTERIAL STIFFNESS"
            },
            "short": "STRESS HYPOXIC CONDITIONS",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-04-01T02:00:00+02:00",
            "begin_effective": "2011-03-28T02:00:00+02:00",
            "end_planned": "2011-12-30T01:00:00+01:00",
            "end_effective": "2011-12-30T01:00:00+01:00",
            "assignment": "2011-03-29T11:56:04+02:00",
            "program": null,
            "subprogram": null,
            "organization": 29447,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 60040,
            "contact": 60040,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2457-60040-10"
            ]
        },
        {
            "id": 2438,
            "title": {
                "de": "Genvarianten in den RAD51-, XRCC2-, XRCC3-, XPD- und XPG-Genen als Prädiktionsfaktoren für Metastasierung bei PatientInnen mit Weichteilsarkomen",
                "en": "Genetic variants in the RAD51, XRCC2, XRCC3, XPD and XPG genes as predictors of outcome in soft tissue sarcoma patients"
            },
            "short": "SOFT TISSUE SARCOMA PATIENTS",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-12-01T01:00:00+01:00",
            "begin_effective": "2011-04-01T02:00:00+02:00",
            "end_planned": "2011-12-01T01:00:00+01:00",
            "end_effective": "2012-03-30T02:00:00+02:00",
            "assignment": "2011-03-03T12:10:08+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14085,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 69234,
            "contact": 69234,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2438-69234-10",
                "2438-58814-12"
            ]
        },
        {
            "id": 1735,
            "title": {
                "de": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 8: Lipid droplet-associated proteins regulating lipid storage and release in macrophages and foam cells",
                "en": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 8: Lipid droplet-associated proteins regulating lipid storage and release in macrophages and foam cells"
            },
            "short": "GOLD3_KRATKY",
            "url": null,
            "abstract": {
                "de": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.",
                "en": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis."
            },
            "begin_planned": "2008-12-01T01:00:00+01:00",
            "begin_effective": "2009-02-01T01:00:00+01:00",
            "end_planned": "2011-11-30T01:00:00+01:00",
            "end_effective": "2012-04-30T02:00:00+02:00",
            "assignment": "2009-01-22T11:56:26+01:00",
            "program": 73,
            "subprogram": null,
            "organization": 14013,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 51904,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                152
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "1735-51904-10",
                "1735-58794-11"
            ]
        },
        {
            "id": 2607,
            "title": {
                "de": "Die Rolle der Phospholipid-Scramblase 1 (PLSCR1) in der Differenzierung und Fusion von humanen Trophoblasten ",
                "en": "The role of Phospholipid-Scramblase 1 (PLSCR1) in human trophoblast differentiation and fusion"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-05-13T02:00:00+02:00",
            "begin_effective": "2011-05-13T02:00:00+02:00",
            "end_planned": "2011-11-30T01:00:00+01:00",
            "end_effective": "2011-11-30T01:00:00+01:00",
            "assignment": "2011-10-05T11:53:24+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14017,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 53232,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                530
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2607-53232-10"
            ]
        },
        {
            "id": 2504,
            "title": {
                "de": "Subtyp-spezifische, nicht kompetitive metabotrope Glutamatrezeptor-1 Antoagonisten als neuer alternativer Therapieansatz bei neuroendokrinen Tumoren",
                "en": "Subtype-specific, non competitive metabotropic glutamatereceptor-1 antagonists as novel alternative therapeutic option for neuroendocrine tumors"
            },
            "short": "glutamate-receptor-1 antagonists",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-07-01T02:00:00+02:00",
            "begin_effective": "2011-07-01T02:00:00+02:00",
            "end_planned": "2011-11-30T01:00:00+01:00",
            "end_effective": "2012-01-31T01:00:00+01:00",
            "assignment": "2011-06-21T11:36:12+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14014,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2568,
            "title": {
                "de": "Akustisches Interface zur Tremoranalyse",
                "en": "Acoustic interface for tremoranalysis"
            },
            "short": "ACOUSTIC INTERFACE TREMORANALYSIS",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-09-01T02:00:00+02:00",
            "begin_effective": "2011-09-01T02:00:00+02:00",
            "end_planned": "2011-11-30T01:00:00+01:00",
            "end_effective": "2012-10-31T01:00:00+01:00",
            "assignment": "2011-09-06T12:41:59+02:00",
            "program": null,
            "subprogram": "Forschung Steiermark - Planung, Steuerung, Impulse\r\nHTI",
            "organization": 14051,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 1714,
            "title": {
                "de": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling",
                "en": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling"
            },
            "short": "GOLD3_BIRNER_GRUENBERGER",
            "url": null,
            "abstract": {
                "de": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.",
                "en": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis."
            },
            "begin_planned": "2008-12-01T01:00:00+01:00",
            "begin_effective": "2009-02-01T01:00:00+01:00",
            "end_planned": "2011-11-30T01:00:00+01:00",
            "end_effective": "2012-04-30T02:00:00+02:00",
            "assignment": "2009-01-14T12:15:11+01:00",
            "program": 73,
            "subprogram": null,
            "organization": 28394,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 58794,
            "contact": 58794,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                152
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "1714-58794-10"
            ]
        },
        {
            "id": 2496,
            "title": {
                "de": "Einfluss mechanischer Belastung auf die Expression von Matrix Metalloproteasen in Knorpelzellen aus der kindlichen Wachstumsfuge",
                "en": "Influence of mechanical strain on the expression of Matrix Metalloproteases in chondrocytes from the infant growth plate"
            },
            "short": "KINDLICHE WACHSTUMSFUGE",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-06-01T02:00:00+02:00",
            "begin_effective": "2011-06-01T02:00:00+02:00",
            "end_planned": "2011-11-30T01:00:00+01:00",
            "end_effective": "2012-02-28T01:00:00+01:00",
            "assignment": "2011-06-10T12:21:53+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14049,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        }
    ]
}