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GET /v1/research/project/?format=api&offset=1940&ordering=end_planned
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1960&ordering=end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1920&ordering=end_planned", "results": [ { "id": 7739, "title": { "de": "Evaluierung innovativer molekularer Analyseverfahren und -ansätze zur Überwachung von Antibiotikaresistenzen im Abwasser", "en": "Evaluation of innovative molecular analytical methods and approaches for monitoring antibiotic resistance in wastewater" }, "short": "ARISE", "url": null, "abstract": { "de": "Universelle DNA/RNA Diagnostik. Es soll die technische Realisier- und Leistungsfähigkeit einer neuen universell einsetzbaren molekularbiologischen Nachweisstrategie für die robuste und sensitive DNA/RNA-Diagnostik biologischer („emerging“) Gefährdungen aller Art für das Abwassermonitoring von Morgen demonstriert werden. Dies wird am Beispiel bakterieller Antibiotikaresistenzen (ARB) – auf Basis einer zukunftsweisenden neuartigen molekularbiologischen Toolbox – durchgeführt. Einerseits stellt die ARB-Problematik eine der größten zukünftigen medizinischen globalen Herausforderungen dar (= größte Relevanz), andererseits sind bereits neue leistungsfähige methodische Teillösungen vorhanden, die in kurzer Zeit zur vorgeschlagenen Toolbox kombiniert werden können (= schnelle Umsetzbarkeit). Da diese auf einer Analyse genetischer Sequenzen basiert, ist eine schnelle Ausweitung auf andere biologische Gefährdungen möglich (nach Anpassung der Sampling- und Probenaufarbeitung).\r\nWasserkreislauf-basierter Ansatz. Die vorgeschlagene Nachweisstrategie soll darüber hinaus erstmals simultane Rückschlüsse auf, i) Verbreitung und Infektionsprävalenz des überwachten Bevölkerungskollektivs im Einzugsgebiet der Abwasserentsorgung (d.h. eigentliche Abwasser-epidemiologie - „Upstream-Verfahren“), als auch, ii) die Gefährdung für Mensch- und Natur (z.B. Nutzung als Badewässer, Trinkwasser oder Fischereigewässer) im Zuge der Ausbreitung über den nachgeschalteten Vorfluter und Wasserkreislauf, ermöglichen (d.h. nutzungsbasierte Gefährdungs- und Risikoanalyse der beeinflussten Wasserressource). \r\nOne-Health Monitoring & Management. Da ARB – wie auch viele andere biologische Gefährdungen – humanen und tierischen Ursprung haben und beidseitige Relevanz besitzen können, wird das vorgeschlagene Tool auf alle Arten fäkaler Abwässer entwickelt und ermöglicht eine Zuordnung und Differenzierung (molekulares fäkales Source-Tracking). Dadurch wird eine universell anwendbare Toolbox im Sinne eines One-Health Ansatzes ermöglicht.\r\nBis Dato vorhandene Limitierungen. Verfügbare molekularbiologische Anwendungen sind i.d.R. i) sensitiv und spezifisch, aber auf wenige Targets beschränkt (z.B. qPCR, RT-qPCR), oder, ii) universell, auf viele Targets einsetzbar, aber wenig sensitiv (z.B. gängige Hochdurchsatz-Sequenzierungsmethoden). Zum anderen erfolgt der Nachweis biologischer Gefährdungen im Abwasser bislang weitgehend ohne Berücksichtigung der Quantität und Qualität der fäkalen Belastungssituation (d.h. Ausmaß, Charakteristik und Herkunft der fäkalen mikrobiologischen Beeinflussung).\r\n", "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2023-08-29T16:37:42+02:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 2, "manager": 58733, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "FO999905348", "ethics_committee": null, "edudract_number": null, "persons": [ "7739-54018-11", "7739-58733-10", "7739-103077-12" ] }, { "id": 7896, "title": { "de": "Verbesserung der MALDI-TOF-Identifizierung von Pseudomonas-Arten: Ein Schritt zur schnellen und genauen Untersuchung", "en": "Improvement of MALDI-TOF identification of Pseudomonas species: A step towards fast and accurate investigation of antimicrobial susceptibility " }, "short": null, "url": null, "abstract": { "de": "Pseudomonas ist weit verbreitet, insbesondere in aquatischen Umgebungen, und kann dort unter verschiedenen Bedingungen gut überleben. Pseudomonas kann Infektionen bei Menschen, Tieren und Pflanzen verursachen. Die hohe natürliche Antibiotikaresistenz stellt ein besonderes Problem in der Humanmedizin dar. In den letzten Jahren hat die Anzahl der Arten aus dem Genus ebenfalls erheblich zugenommen, und Studien deuten darauf hin, dass viele Arten noch zu beschreiben sind. Um die Bedeutung dieser verschiedenen Arten für die Umwelt, aber auch für den Menschen zu verstehen, ist eine gute und einfache Unterscheidung der einzelnen Arten erforderlich.\r\n\r\nDie Zusammenarbeit zwischen ANSES und MUG wird die MALDI-TOF-Differenzierung und eine offene Datenbank nutzen, um eine Methode zur schnellen, kostengünstigen und zuverlässigen Bestimmung von Pseudomonas-Arten zu entwickeln. Die Stammsammlungen der beiden Institutionen dienen als Grundlage. Diese umfassen Isolate aus der Umwelt sowie aus humanen und veterinären Proben. Die Isolate sollen durch Sequenzierung und MALDI-TOF charakterisiert werden. Die Resistenz gegenüber wichtigen Antibiotika wird ebenfalls an diesen Isolaten mit beiden Methoden, Agardiffusion und Mikrodilution, getestet.\r\n\r\nDie MALDI-TOF-Proben werden in einer frei zugänglichen Datenbank platziert. Diese Anwendung wird kostenlos sein und von jedermann genutzt werden können. Ein weiterer Vorteil wird sein, dass man mit der Anwendung in Kontakt mit anderen Forschern kommen kann, die an Pseudomonas arbeiten, und so ein Pseudomonas-Netzwerk aufgebaut werden könnte. Wenn dieses Projekt erfolgreich ist, könnte es auch auf andere Bakteriengruppen (z. B. Aeromonas, Bacilli usw.) angewendet werden. In jedem Fall legt diese Arbeit den Grundstein für eine enge Zusammenarbeit zwischen ANSES und MUG auf dem Gebiet der Pseudomonadenforschung.", "en": "Pseudomonas that is widespread, especially in aquatic environments, and can survive well there under various conditions. Pseudomonas can cause infections in humans, animals and plants. The high natural resistance to antibiotics is a particular problem in human medicine. In recent years, the number of species from the genus has also increased considerably and studies suggest that many species remain to be described. To understand the importance of these different species for the environment but also for humans, a good and simple differentiation of the individual species is necessary.\r\nThe collaboration between ANSES and MUG will use MALDI TOF differentiation and an open database to develop a method for fast, cheap and reliable determination of species of Pseudomonas.\r\nStrain collections of the two institutions serve as a basis. These include isolates from the environment, from human and veterinary samples. The isolates are to be chartered by sequencing and MALDI TOF. Resistance to important antibiotics will also be tested in these isolates using btoh methods Agar diffusion and Micro broth dilution. MALDI TOF specimens will be placed in a open accessible database. This application will be free of charge and can be used by anyone. Another advantage will be that with the application one can get in touch with other researchers working on Pseudomonas and thus a Pseudomonas network could be established\r\nIf this project proves successful, it could also be applied to other groups of bacteria (e.g. Aeromonas, Bacilli, etc.). In any case, this work lays the foundation for close collaboration between ANSES and MUG in the field of Pseudomonads research. The participating institutions in France and Austria have different and complementary expertise in the research of this genus. A harmonisation and an efficient exchange of methods will be a key factor for both, to deepen their standing in this field of research and to other aquatic genera like Vibrio, Aeromonas.\r\n" }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2023-11-21T15:29:59+01:00", "program": 207, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 58733, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "FR 01/2024", "ethics_committee": null, "edudract_number": null, "persons": [ "7896-54018-12", "7896-58733-10", "7896-103077-12" ] }, { "id": 8316, "title": { "de": "Uterine Trophoblasteninvasion: Ein mastrixbasiertes 3D-Gefäßmodel zur \r\nCharakterisierung schwangerschaftsassozierter Erkrankungen", "en": "Uterine trophoblast invasion: A mastrix-based 3D vascular model for the characterization of pregnancy-associated diseases" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-07-29T15:26:52+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 76930, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8316-76930-10", "8316-97931-11" ] }, { "id": 9078, "title": { "de": "Einfluss von Humanmilch-Oligosacchariden auf das Harnmikrobiom in der Schwangerschaft", "en": "Influence of human milk oligosaccharides on the urinary microbiome during pregnancy" }, "short": "Humanmilch_Harnmikrobiom_StadtGraz", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-04-01T02:00:00+02:00", "begin_effective": "2025-04-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2025-07-08T12:54:31+02:00", "program": null, "subprogram": null, "organization": 14064, "category": 10, "type": 10, "partner_function": 4, "manager": 88993, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9078-88993-10" ] }, { "id": 6571, "title": { "de": "PERSONALISIERUNG DER IMMUNSUPPRESSION DURCH ÜBERWACHUNG DER VIRUSLAST NACH NIERENTRANSPLANTATION - EINE RANDOMISIERTE, KONTROLLIERTE PHASE-II-STUDIE", "en": "PERSONALISATION OF IMMUNOSUPPRESSION BY MONITORING VIRAL LOAD POST KIDNEY\r\nTRANSPLANTATION - A RANDOMISED CONTROLLED PHASE II TRIAL" }, "short": "TTV GUIDE TX", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-01-01T01:00:00+01:00", "begin_effective": "2021-05-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-04-30T02:00:00+02:00", "assignment": "2021-05-11T12:03:53+02:00", "program": 109, "subprogram": null, "organization": 14084, "category": 10, "type": 10, "partner_function": 2, "manager": 74174, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6571-100601-12", "6571-74174-10", "6571-74175-12", "6571-75657-12", "6571-86124-12", "6571-86588-12", "6571-104723-12", "6571-118529-12" ] }, { "id": 7363, "title": { "de": "Digitale Zwillinge für die Behandlung von Vorhofflimmern", "en": "Digital Twins to Treat Atrial Fibrillation" }, "short": "DAWN-AF", "url": null, "abstract": { "de": "Vorhofflimmern (VHF) ist die häufigste Arrhythmie des Herzens. Bei VHF handelt es sich um eine fortschreitende Erkrankung des Herzens. Je länger VHF andauert, umso schwieriger ist die Behandlung, und das Risiko Folgeschäden wie Schlaganfälle, Demenz oder Herzinsuffizienz zu erleiden nimmt zu. Die effektivste Therapie für VHF ist die Ablationstherapie mittels Herzkatheter, eine Prozedur, bei der Gewebe in den Vorhöfen des Herzens zerstört wird um die Ausbreitungspfade von elektrischen Wellen einzuschränken. Aktuelle Therapieformen sind generisch, die Variabilität der Patienten hinsichtlich der Struktur der Vorhöfe wird nicht berücksichtigt, weshalb VHF-Symptome auch nach anfänglich positiver Therapie häufig zurückkehren.\r\n\r\nDas Ziel des DAWN-AF Projektes ist es, einen personalisierten medizinischen Ansatz zu entwickeln, der auf Computermodellierung basiert. Konkret werden digitale Zwillinge der Vorhöfe des Herzens entwickelt. Diese können zur verbesserten Planung der VHF-Ablation im Computer verwendet werden, um ein Wiederauftreten von VHF zu verhindern. Dazu werden präoperative Messungen wie das Elektrokardiogramm und tomographische Bildgebung (MRT/CT) verwendet, um anatomisch und funktionell detaillierte digitale Zwillinge zu erstellen. Da diese Daten jedoch nicht ausreichen, um die Vorhöfe eindeutig zu charakterisieren, wird für jeden Patienten ein Satz an potenziellen digitalen Zwillingen erstellt, um dann für jede einzelne Variation die jeweils ideale Ablationsbehandlung zu bestimmen. Anhand von invasiven Messungen während des Eingriffs wird dann derjenige digitale Zwilling ausgewählt, der am besten zum Patienten passt. Eine wirtschaftliche Analyse der VHF-Therapie wird den Nutzen unseres mittels digitaler Zwillinge personalisierten Therapiezugangs bewerten. Dieser Nutzen ergibt sich aus einer frühzeitigen präventiven Behandlung, aus einem länger anhaltenden Therapieerfolg, aus einer verkürzten Eingriffsdauer und einer Reduktion des Eingriffsrisikos.\r\n", "en": "Atrial Fibrillation (AF) is the most common cardiac arrhythmia. Since AF is progressive, the longer one has it, the harder it is to treat, and the risks of stroke, dementia and heart failure increase. The most effective treatment is catheter ablation therapy, a procedure that strategically destroys tissue to restrict propagation of electrical waves. However, approaches are currently generic, ignoring patient variability in atrial structure, and AF usually recurs. We aim to develop a personalised medicine approach based on computer modelling, to use digital twins to plan AF ablation to prevent recurrence. We propose to use preoperative measurements, imaging (MRI/CT) and the ECG, to build digital twins. However, these data are insufficient to uniquely characterize the atria, so we will build sets of potential digital twins for each patient, each of which will have its ideal ablation treatment determined. Invasive measurements acquired during the ablation procedure will be then used to select the digital twin that best matches the patient. Economic analysis will evaluate benefits arising from early preventative and longer-lasting treatment, reduced duration and procedural risks of interventions." }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-03-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-09-28T02:00:00+02:00", "assignment": "2023-02-01T16:15:05+01:00", "program": 112, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 2, "manager": 50966, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I 6476-B", "ethics_committee": null, "edudract_number": null, "persons": [ "7363-50966-10", "7363-91352-12", "7363-96212-12", "7363-50967-12", "7363-122514-12" ] }, { "id": 7889, "title": { "de": "Magnetische molekularimprintete Polymere als eine Platform für den Wirkstofftransport", "en": "Magnetic Molecularly Imprinted Polymers as a Platform for Drug Delivery\r\n" }, "short": "MMIPP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2023-11-20T11:36:13+01:00", "program": 207, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 2, "manager": 113130, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "FR 05/2024", "ethics_committee": null, "edudract_number": null, "persons": [ "7889-113130-10" ] }, { "id": 8561, "title": { "de": "Gewaltambulanz\r\nder Medizinischen Universität Graz und Konzept für die\r\nflächendeckende Versorgung", "en": "-" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-04-01T02:00:00+02:00", "begin_effective": "2024-04-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-12-12T14:44:55+01:00", "program": null, "subprogram": null, "organization": 14019, "category": 10, "type": 10, "partner_function": 4, "manager": 115441, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8561-115441-10" ] }, { "id": 8294, "title": { "de": "Der Zusammenhang zwischen Körpergewicht und kortikaler Neuroplastizität und Lernen – eine Pilotstudie", "en": "The relationship between Body Weight and Human Motor Cortical Plasticity and Learning" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-10-01T02:00:00+02:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-04-30T02:00:00+02:00", "assignment": "2024-07-10T16:17:43+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 58643, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": "FIF-A 16-0532/2024-0001", "ethics_committee": null, "edudract_number": null, "persons": [ "8294-58643-10" ] }, { "id": 7916, "title": { "de": "ARCTECH: Das Potenzial von Archaea nutzbar machen\r\nAusbildung der nächsten Visionäre Europas für eine innovative und nachhaltige Zukunft", "en": "ARCTECH: Harnessing the potential of Archaea\r\nTraining Europe’s next visionaries for an innovative and sustainable future" }, "short": "ARCTECH", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2024-03-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2028-02-29T01:00:00+01:00", "assignment": "2023-12-07T10:05:45+01:00", "program": 209, "subprogram": "HORIZON-MSCA-2022-DN-01", "organization": 14023, "category": 10, "type": 10, "partner_function": 2, "manager": 90021, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101120407", "ethics_committee": null, "edudract_number": null, "persons": [ "7916-90021-10", "7916-99612-12", "7916-100035-12", "7916-104024-12", "7916-109121-12", "7916-100806-12", "7916-106195-12", "7916-111471-12", "7916-128134-12" ] }, { "id": 7278, "title": { "de": "CDK9 Inhibition bei RAS-mutierter CMML", "en": "CDK9 inhibition in RAS-mutated CMML" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-03-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2027-06-30T02:00:00+02:00", "assignment": "2022-12-01T10:38:07+01:00", "program": 72, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 57402, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P36672", "ethics_committee": null, "edudract_number": null, "persons": [ "7278-57402-10", "7278-97430-12", "7278-122511-12" ] }, { "id": 6942, "title": { "de": "CBmed: MODUL - Mikroplastik: Eine Gefahr für die menschliche Gesundheit Projekt 3\r\nInteraktion - Gesundheitseffekte - Prävention", "en": "CBmed: MODUL - Microplastic Particles: A Hazard for Human Health Project 3\r\nINTERACTION – HUMAN HEALTH EFFECTS – TREATMENT" }, "short": "MicroONE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2022-03-02T13:48:50+01:00", "program": 94, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 50989, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6942-81091-12", "6942-107131-12", "6942-106674-12", "6942-112689-12", "6942-50989-10", "6942-114553-12", "6942-115621-12", "6942-125874-12", "6942-126494-12", "6942-124112-12" ] }, { "id": 7913, "title": { "de": "NeEDs - necessary decision support system", "en": "NeEDs - necessary decision support system" }, "short": "NeEDs", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2023-12-05T10:18:58+01:00", "program": null, "subprogram": null, "organization": 14076, "category": 10, "type": 10, "partner_function": 4, "manager": 78071, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1040 ], "funder_projectcode": "1.000.072.603", "ethics_committee": null, "edudract_number": null, "persons": [ "7913-78071-10" ] }, { "id": 8752, "title": { "de": "Aufbau der Grazer Ambulanz für Riech- und Schmeckstörungen", "en": "Establishment of the Graz Clinic for Smell and Taste Disorders" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-06-01T02:00:00+02:00", "begin_effective": "2025-05-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2025-04-01T19:13:16+02:00", "program": null, "subprogram": null, "organization": 14066, "category": 10, "type": 10, "partner_function": 4, "manager": 89704, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": "FIF-A 16-0020/2025-0001", "ethics_committee": null, "edudract_number": null, "persons": [ "8752-89704-10" ] }, { "id": 7215, "title": { "de": "Die Bedeutung von \"Glial Fibrillary Acidic Pretein\" im Plasma als diagnostischer und prognostischer Marker der Hirnalterung und der Alzheimer Krankheit", "en": "The Role of Plasma Glial Fibrillary Acidic Protein as a diagnostic and prognostic marker in brain aging and Alzheimer´s disease" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2022-10-13T14:04:13+02:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 57435, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2269 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7215-57435-10", "7215-73547-11" ] }, { "id": 8532, "title": { "de": "Identifizierung Glykosylierungs-bezogener Biomarker\r\nzur Stratifizierung des Schweregrads beim chronischen Fatigue Syndrom", "en": "Exploring the Glycome: Identifying Glycosylation-Related Biomarkers\r\nfor severity stratification in Chronic Fatigue Syndrome" }, "short": "GlycoExplore-CFS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-02-28T01:00:00+01:00", "assignment": "2024-11-27T12:11:08+01:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 1, "manager": 120271, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1844 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8532-120271-10" ] }, { "id": 8710, "title": { "de": "Klinisch-immunologische Charakterisierung der Chronischen Rhinosinusitis", "en": "Clinical-immunological characterization of chronic rhinosinusitis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-05-01T02:00:00+02:00", "begin_effective": "2025-05-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2027-12-31T01:00:00+01:00", "assignment": "2025-03-06T10:01:42+01:00", "program": null, "subprogram": null, "organization": 14066, "category": 10, "type": 10, "partner_function": 4, "manager": 89704, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": 12, "language": null, "funders": [ 457 ], "funder_projectcode": "FIF-A 16-0479/2024-0002", "ethics_committee": null, "edudract_number": null, "persons": [ "8710-89704-10" ] }, { "id": 6474, "title": { "de": "GROUND-BREAKING ELECTROPORATION-BASED INTERVENTION FOR ATRIAL FIBRILLATION TREATMENT (BEAT AF)", "en": "GROUND-BREAKING ELECTROPORATION-BASED INTERVENTION FOR ATRIAL FIBRILLATION TREATMENT (BEAT AF)" }, "short": "BEAT AF", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-01-01T01:00:00+01:00", "begin_effective": "2021-03-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-02-28T01:00:00+01:00", "assignment": "2021-03-01T21:04:25+01:00", "program": 109, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 2, "manager": 50168, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": " 945125", "ethics_committee": null, "edudract_number": null, "persons": [ "6474-50168-10" ] }, { "id": 8503, "title": { "de": "„Mikroperfusion der Haut zur Bestimmung von Veränderungen des Mikromilieus der Haut bei SSc“", "en": "Dermal open flow microperfusion to determine changes in the skin microenvironment in vivo during SSc" }, "short": "SSc_OFM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-11-01T01:00:00+01:00", "begin_effective": "2024-11-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-11-19T13:55:23+01:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 1, "manager": 120271, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2296 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8503-120271-10" ] }, { "id": 7055, "title": { "de": "Lösung des offenen Rätsels von TRPC3 durch Photopharmakologie", "en": "Resolving the open state enigma of TRPC3 by photopharmacology" }, "short": null, "url": null, "abstract": { "de": "• Wider research context / theoretical framework: TRPC3 is a distinct member of TRPC family. This channel is expressed in excitable and non-excitable cells. By non-selectively conducting cations even at its resting state, TRPC3 promotes cellular processes in both health and disease. However, there are only a few modulators of this channel available. To precisely design new therapeutic ligands, it is of high importance to gain knowledge about TRPC3 protein structure and, consequently, its gating mechanism. Recently, two TRPC3 structures were revealed by cryo electron microscopy (cryo-EM). Nonetheless, neither of them captured open pore architecture. Hence, the open conformations is the critical missing piece of information to solve the TRPC3 gating puzzle. This knowledge is essential for comprehension of the molecular function of TRPC3 and definition of possible ligand binding sites to control this channel is health and, especially, disease.\r\n• Hypotheses / research questions / objectives: Here, we propose to succeed in capturing open pore structures of TRPC3 by stabilizing and synchronizing the channels at a high open probability using photochromic ligands and in addition by preserving their lipid environment during the protein preparation for cryo-EM.\r\n• Approach / methods: We will screen two expression systems for suitability to maintain TRPC3 in open conformation. We will utilize photopharmacological tools for a temporal control over TRPC3 gating during protein extraction and cryo-EM. Structural details obtained from cryo-EM will be followed by structure-guided mutagenesis and evaluated in a multifunctional live cell approach combining Ca2+ imaging and electrophysiology.\r\n• Level of originality / innovation: With our project, we will introduce a novel approach to control protein conformations during cryo-EM by photoswitchable ligands. Our work will unravel TRPC3 open architecture and promote the development of new concepts for therapeutic targeting of these channels.\r\n• Primary researchers involved: The research team will include profound experts in TRPC3 electrophysiology and Ca2+ signaling Dr. Oleksandra Tiapko and Dr. Klaus Groschner (Medical University of Graz, Austria), experts in membrane lipids Dr. Anita Emmerstorfer-Augustin (Graz University of Technology) and in structural biology and electron microscopy Dr. Christine Ziegler (University of Regensburg).", "en": "• Wider research context / theoretical framework: TRPC3 is a distinct member of TRPC family. This channel is expressed in excitable and non-excitable cells. By non-selectively conducting cations even at its resting state, TRPC3 promotes cellular processes in both health and disease. However, there are only a few modulators of this channel available. To precisely design new therapeutic ligands, it is of high importance to gain knowledge about TRPC3 protein structure and, consequently, its gating mechanism. Recently, two TRPC3 structures were revealed by cryo electron microscopy (cryo-EM). Nonetheless, neither of them captured open pore architecture. Hence, the open conformations is the critical missing piece of information to solve the TRPC3 gating puzzle. This knowledge is essential for comprehension of the molecular function of TRPC3 and definition of possible ligand binding sites to control this channel is health and, especially, disease.\r\n• Hypotheses / research questions / objectives: Here, we propose to succeed in capturing open pore structures of TRPC3 by stabilizing and synchronizing the channels at a high open probability using photochromic ligands and in addition by preserving their lipid environment during the protein preparation for cryo-EM.\r\n• Approach / methods: We will screen two expression systems for suitability to maintain TRPC3 in open conformation. We will utilize photopharmacological tools for a temporal control over TRPC3 gating during protein extraction and cryo-EM. Structural details obtained from cryo-EM will be followed by structure-guided mutagenesis and evaluated in a multifunctional live cell approach combining Ca2+ imaging and electrophysiology.\r\n• Level of originality / innovation: With our project, we will introduce a novel approach to control protein conformations during cryo-EM by photoswitchable ligands. Our work will unravel TRPC3 open architecture and promote the development of new concepts for therapeutic targeting of these channels.\r\n• Primary researchers involved: The research team will include profound experts in TRPC3 electrophysiology and Ca2+ signaling Dr. Oleksandra Tiapko and Dr. Klaus Groschner (Medical University of Graz, Austria), experts in membrane lipids Dr. Anita Emmerstorfer-Augustin (Graz University of Technology) and in structural biology and electron microscopy Dr. Christine Ziegler (University of Regensburg)." }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-10-31T01:00:00+01:00", "assignment": "2022-06-13T15:55:42+02:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 90337, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": " P 35291", "ethics_committee": null, "edudract_number": null, "persons": [ "7055-90337-10", "7055-116421-12" ] } ] }