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GET /v1/research/project/?format=api&offset=1940&ordering=end_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1960&ordering=end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1920&ordering=end_effective", "results": [ { "id": 9181, "title": { "de": "Metabolische Anpassungen von Lungenkrebszellen bei Hemmung der Glykolyse", "en": "Metabolic adaptations of lung cancer cells to glycolysis inhibition" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-11-01T01:00:00+01:00", "begin_effective": "2025-11-01T01:00:00+01:00", "end_planned": "2026-06-30T02:00:00+02:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2025-09-04T10:32:00+02:00", "program": 204, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 105621, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9181-105621-10" ] }, { "id": 9104, "title": { "de": "Wirkung von S. auf die Adipozyten–Makrophagen-Kommunikation im Lipödem", "en": "Effect of S. on the adipocyte-macrophage-crosstalk in lipedema" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-07-01T02:00:00+02:00", "begin_effective": "2025-07-01T02:00:00+02:00", "end_planned": "2026-06-30T02:00:00+02:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2025-07-28T16:29:26+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 90806, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9104-90806-10" ] }, { "id": 6520, "title": { "de": "Fäkale Mikrobiomtherapie-Charakterisierung bei Adipositas", "en": "Characterizing Fecal Microbiota Treatment in Human Obesity" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-07-01T02:00:00+02:00", "begin_effective": "2021-07-01T02:00:00+02:00", "end_planned": "2023-06-30T02:00:00+02:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2021-04-08T18:10:53+02:00", "program": 111, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 1, "manager": 50877, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I 5130", "ethics_committee": null, "edudract_number": null, "persons": [ "6520-50877-10", "6520-59231-12", "6520-87054-12", "6520-97866-12", "6520-99940-12", "6520-122513-12" ] }, { "id": 8333, "title": { "de": "Assessment of the cardiovascular risk profile of infants exposed to pre-eclampsia in utero", "en": "Assessment of the cardiovascular risk profile of infants exposed to pre-eclampsia in utero" }, "short": "CARIPRE-ECLAMPSIA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-07-01T02:00:00+02:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2026-06-30T02:00:00+02:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2024-08-08T11:09:42+02:00", "program": 254, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 3, "manager": 57932, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8333-57932-10" ] }, { "id": 8880, "title": { "de": "Effekt von S. auf Immunzellen und Adipozyten von Lipödempatienten", "en": "Effect of S. on the lipedema immune cell compartment and adipocytes\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-07-01T02:00:00+02:00", "begin_effective": "2025-07-01T02:00:00+02:00", "end_planned": "2026-06-30T02:00:00+02:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2025-05-20T14:58:10+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 90806, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8880-90806-10" ] }, { "id": 7973, "title": { "de": "Einfluss der pulmonalen Belastungshämodynamik auf die rechtsventrikuläre Funktion", "en": "Impact of pulmonary exercise hemodynamics on right ventricular function" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-12-01T01:00:00+01:00", "begin_effective": "2023-12-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2024-01-16T14:16:04+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 79732, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2396 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7973-79732-10" ] }, { "id": 8133, "title": { "de": "Alterssuizid in Österreich: Eine Niedrig- und Hochrisikopopulationsstudie basierend auf verknüpften personenbezogenen Registerdaten", "en": "Suicide among older adults in Austria: A low- and high-risk population study based on linked individual-level register data" }, "short": "SAOAA", "url": "https://www.oeaw.ac.at/foerderungen/data-research-austria", "abstract": { "de": "Der Suizid eines Menschen ist eine Tragödie auf individueller Ebene und gleichzeitig ein Problem der öffentlichen Gesundheitsfürsorge auf gesellschaftlicher Ebene. Wenig bekannt ist dabei, dass die Suizidraten sowohl in Österreich als auch allen anderen europäischen Ländern stark mit dem Alter ansteigen. Die allerhöchsten Suizidraten finden sich bei hochaltrigen Männern. Österreich hat gegenwärtig eine der höchsten Suizidraten bei Hochaltrigen in ganz Europa und es wird erwartet, dass die absolute Zahl der Suizide bei älteren Menschen in den nächsten Dekaden aufgrund der fortschreitenden Überalterung der Bevölkerung, insbesondere durch das Älterwerden der Babyboomer-Generation, steigen wird. Die zentrale Forschungsfrage dieses Projekts ist daher, welche Risikofaktoren Suizide bei älteren Menschen in Österreich vorhersagen können, was in weiterer Folge dazu beitragen soll, Präventionsmaßnahmen zu verbessern. Vor dem Hintergrund erstmalig zugänglicher und auf individueller Ebene verknüpfbarer Registerdaten in Österreich durch das Austria Micro Data Center (AMDC) soll im Rahmen dieses Projekts untersucht werden, welche älteren Personengruppen ein erhöhtes Risiko für Suizid haben. Konkret planen wir Risikofaktoren in zwei Bevölkerungsgruppen zu untersuchen: (1) die gesamte ältere Allgemeinbevölkerung (Niedrigrisiko-Ansatz) und (2) ältere gerontopsychiatrische Patient*innen (Hochrisiko-Ansatz). Potentielle Risikofaktoren werden demographische und sozioökonomische Faktoren, körperliche und psychische Erkrankungen, Pflegebedürftigkeit und soziale Isolation umfassen. Dabei werden diese Risikofaktoren nicht nur isoliert voneinander betrachtet, sondern auch deren multiplikativer Effekt, d.h. wenn beispielsweise der Verlust eines Partners mit einer neuen Krebsdiagnose zusammenfällt, untersucht. Mit diesem Forschungsprojekt wollen wir den Alterssuizid in Österreich besser verstehen und damit eine bessere Grundlage für Präventionsmaßnahmen schaffen, und nicht zuletzt die Lebensumstände jener älteren Personen besser zu beleuchten, die keinen anderen Ausweg sehen, als sich selbst (oft mit Gewalt) das Leben zu nehmen. ", "en": "Suicide is a tragedy at the individual level and a serious public health problem at the societal level. Although often overlooked, suicide rates in both Austria and other European countries increase rapidly with age, so that the highest suicide rates tend to show among the oldest old, and here, specifically among men. Austria has one of the highest suicide rates among the oldest old within the EU-27 countries. The high number of suicide deaths among older adults in Austria is not only a present-day concern, but also worrying against the background of population ageing, specifically the ageing of the large baby boomer generation, as this will likely lead to an increase in the absolute number of suicides among older adults in the decades ahead. The main research question of this project therefore is what risk factors can predict old age suicides in Austria, which can subsequently inform suicide prevention efforts. Against the background of newly available individual-level register data linkage in Austria within the Austrian Micro Data Center (AMDC), the aim of this project is to provide new and hitherto unavailable evidence on who among the older population is at an elevated risk of suicide death. Specifically, we seek to identify risk factors in two populations: (1) the whole general older population (low-risk setting) and (2) older psychiatric inpatients (high-risk setting). Risk factors will include demographic and socioeconomic factors, physical and mental health problems, disability and social disconnectedness. We will not only look at these factors in isolation, but also assess whether there are multiplicative effects for suicide risk, that is, when multiple risk factors co-occur at the same time, e.g. when the loss of spouse coincides with a cancer diagnosis. With this research project, we aim to better understand old age suicide in Austria, to inform suicide prevention efforts, and to illuminate the life circumstances of those older adults who see no other way but to (often violently) end their own lives." }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2024-04-10T11:05:11+02:00", "program": 245, "subprogram": null, "organization": 14024, "category": 10, "type": 10, "partner_function": 1, "manager": 89152, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8133-89152-10", "8133-119651-12", "8133-128434-12" ] }, { "id": 7011, "title": { "de": "Quantitative Susceptibilitätsbildgebung mit Deep Learning", "en": "Deep Learning for Quantitative Susceptibility Mapping" }, "short": "deepQSM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-07-01T02:00:00+02:00", "begin_effective": "2022-07-01T02:00:00+02:00", "end_planned": "2025-06-30T02:00:00+02:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2022-05-10T12:01:20+02:00", "program": 72, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 60116, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 35887", "ethics_committee": null, "edudract_number": null, "persons": [ "7011-60116-10" ] }, { "id": 8681, "title": { "de": "Smart and Federated Open data eXchange of citizen-based data donations for clinical research", "en": "Smart and Federated Open data eXchange of citizen-baseddata donations for clinical research " }, "short": "SmartFOX", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2025-02-24T16:54:03+01:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 1, "manager": 99976, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8681-99976-10" ] }, { "id": 8277, "title": { "de": "Untersuchung des pro-fibrotischen Potenzials von B-Zellen in der Haut bei systemischer Sklerose", "en": "Investigating the pro-fibrotic potential of B cells in the skin niche during Systemic Sclerosis" }, "short": "SScSkin", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-08-01T02:00:00+02:00", "begin_effective": "2024-08-01T02:00:00+02:00", "end_planned": "2026-07-31T02:00:00+02:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2024-06-27T13:46:39+02:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 3, "manager": 120271, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8277-115661-12", "8277-120271-10", "8277-131740-12" ] }, { "id": 6139, "title": { "de": "Entwicklung einer effizienten und einfachen Methode zur Verbesserung der diagnostischen Prozesse und Performance bei primärem Hyperparathyreoidismus", "en": "Establishing an efficient and simple method to improve diagnostic procedures and performance in primary hyperparathyroidism" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-08-01T02:00:00+02:00", "begin_effective": "2020-08-01T02:00:00+02:00", "end_planned": "2022-07-31T02:00:00+02:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2020-05-19T14:25:06+02:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 1, "manager": 85701, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2427 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6139-85701-10" ] }, { "id": 7619, "title": { "de": "Umfassende genetische Analyse von Patienten und Patientinnen mit Auftreten einer Krebserkrankung in jüngerem Alter", "en": "Comprehensive genetic analysis of patients with onset of cancer at a younger age" }, "short": "CotY", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-05-01T02:00:00+02:00", "begin_effective": "2023-07-01T02:00:00+02:00", "end_planned": "2025-04-30T02:00:00+02:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2023-06-16T10:50:35+02:00", "program": null, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 4, "manager": 57423, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 52 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7619-57423-10" ] }, { "id": 9130, "title": { "de": "Auf dem Weg zu einem umfassenden Atlas des menschlichen Atmungsmikrobioms: Taxonomische, genomische und funktionelle Perspektiven", "en": "Towards a Comprehensive Atlas of the Human Respiratory Microbiome: Taxonomic,\r\nGenomic, and Functional Perspectives" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-10-01T02:00:00+02:00", "begin_effective": "2025-08-01T02:00:00+02:00", "end_planned": "2025-01-01T01:00:00+01:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2025-08-05T13:14:59+02:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 90021, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9130-90021-10" ] }, { "id": 8008, "title": { "de": "Identifizierung neuer Targets in der TP53-vermittelten Therapieresistenz bei akuter myeloischer Leukämie durch CRISPRko-Screens", "en": "Identifying novel targets to combat aberrant TP53 mediated therapeutic resistance in acute myeloid leukemia using CRISPRko screens" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-01T01:00:00+01:00", "begin_effective": "2024-02-01T01:00:00+01:00", "end_planned": "2025-08-01T02:00:00+02:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2024-02-01T11:43:46+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 1, "manager": 101484, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1564 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8008-103341-12", "8008-101484-10" ] }, { "id": 9068, "title": { "de": "Zelltypspezifische in vivo Depletion proliferierender Zellen - Charakterisierung eines einzigartigen neuen genetischen Mausmodells", "en": "Cell-type specific in vivo ablation of proliferating cells – characterization of a unique novel genetic mouse model" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-08-01T02:00:00+02:00", "begin_effective": "2025-08-01T02:00:00+02:00", "end_planned": "2026-07-31T02:00:00+02:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2025-07-04T12:12:41+02:00", "program": null, "subprogram": null, "organization": 14006, "category": 10, "type": 10, "partner_function": 1, "manager": 61540, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9068-61540-10" ] }, { "id": 7086, "title": { "de": "Piezo1 in der Plazenta verbindet Lipide mit Gefäßfunktion", "en": " Piezo1 couples lipids and vascular function in the placenta" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-07-01T02:00:00+02:00", "begin_effective": "2022-08-01T02:00:00+02:00", "end_planned": "2025-06-30T02:00:00+02:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2022-07-06T10:07:59+02:00", "program": 124, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 113634, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "ESP 167", "ethics_committee": null, "edudract_number": null, "persons": [ "7086-50442-12", "7086-56938-12", "7086-59816-12", "7086-100813-12", "7086-113409-12", "7086-113634-10", "7086-114912-12", "7086-119149-12", "7086-125737-12", "7086-130675-12", "7086-128676-12" ] }, { "id": 8381, "title": { "de": "Von der Entstehung einer Arrhythmie bis zur Progression: Aufdeckung der molekularen Mechanismen, die Herzrhythmusstörungen stabilisieren", "en": "From arrhythmia initiation to progression: uncovering the molecular mechanisms stabilizing cardiac arrhythmias using a computational-experimental approach" }, "short": "NWOVidi", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-06-01T02:00:00+02:00", "begin_effective": "2024-06-01T02:00:00+02:00", "end_planned": "2026-08-14T02:00:00+02:00", "end_effective": "2026-08-14T02:00:00+02:00", "assignment": "2024-09-05T19:11:41+02:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 123850, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8381-123850-10" ] }, { "id": 6639, "title": { "de": "Erstellung von Metabolomprofilen aus Plasma und Liquor von Kindern mit seltenen neurologischen Erkrankungen ", "en": "Establishment of plasma and cerebrospinal fluid metabolome profiles of rare neurological diseases in children" }, "short": "Metabolomics/Lipidomics in rare diseases", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-07-01T02:00:00+02:00", "begin_effective": "2021-08-15T02:00:00+02:00", "end_planned": "2024-06-30T02:00:00+02:00", "end_effective": "2026-08-14T02:00:00+02:00", "assignment": "2021-07-06T15:39:00+02:00", "program": 86, "subprogram": null, "organization": 14048, "category": 10, "type": 10, "partner_function": 4, "manager": 84507, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "T1343", "ethics_committee": null, "edudract_number": null, "persons": [ "6639-50450-12", "6639-84507-10", "6639-58455-12", "6639-127259-12" ] }, { "id": 6899, "title": { "de": "Wir alle sind Mischwesen: Mikrochimärsimus, Gesundheit und Evolution", "en": "We All Are Multitudes: the Microchimerism, Human Health and Evolution" }, "short": "Microchimerism and Evolution", "url": "https://www.microchimerism.info/", "abstract": { "de": "Mikrochimärismus (MC) beschreibt die Existenz einer kleinen Anzahl fremder menschlicher Zellen in einer Person. Dieses Phänomen entsteht unter anderem während der Schwangerschaft durch das Wandern von Zellen zwischen Mutter und Fötus. Das derzeitige Wissen um MC ist unvollständig und teils widersprüchlich, über die Rolle, die mikrochimäre Zellen in der Wirtsphysiologie spielen, ist wenig bekannt.\r\nWas ist der Grund der anscheinend paradoxen Effekte von MC? Welche Mechanismen sind beteiligt oder sogar verantwortlich dafür, dass mikrochimäre Zellen ins Wirtsgewebe wandern, sich dort integrieren und oftmals ein Wirtsleben lang verbleiben? Die Evolutionsbiologie und die maternal-fetale Konflikttheorie können einen Rahmen bieten, um die Persistenz mikrochimärer Zellen zu verstehen und deren Existenz mit einer erhöhten Anfälligkeit für Krankheiten zu verknüpfen.\r\nWir gehen zunächst davon aus, dass MC weiter verbreitet ist als bisher berichtet. Wir nehmen weiters an, dass mikrochimäre Zellen eine adaptive Rolle in der Physiologie des Wirts zu spielen vermögen und Vorteile für Mütter und Nachkommen bieten können, etwa durch Übertragung von Stammzellen und anderen Zelltypen aber auch durch Übertragung von wichtigen Komponenten des und Signalen für das Immunsystem. Jedoch werden sich in manchen Geweben die maternal-fötalen genetischen Interessen nicht zur Deckung bringen lassen, was eine erhöhte Anfälligkeit für Krankheiten zur Folge haben kann. Daher ist es unser Ziel, den Einfluss des MC auf Gesundheit und Krankheit zu studieren und Potential und Effekte des Zelltransfers über Generationengrenzen hinweg zu verstehen.\r\nBasis unseres Projekts ist die Verwendung modernster Technologien zur Analyse des bidirektionalen Transfers mikrochimärer Zellen zwischen Individuen und die Verteilung der mikrochimären Zellen in den Zielgeweben. Weiters widmen wir uns den Effekten, die aus der Interaktion von mikrochimären Zellen und dem Immunsystem des Wirts hervorgehen. Diese Themen studieren wir in mehreren Teilprojekten: Erstellung eines Maus-Mikrochiom-Atlas (Projekt 1), Phänotypisierung von maternalem (Projekt 2) und fetalem (Projekt 3) MC, Charakterisierung von mikrochimären Zellen in plazentanahen, -fernen Geweben und diversen Organen (Projekt 4) sowie den Zusammenhang von MC und Autoimmunerkrankung im Tiermodell (Projekt 5).\r\nUnsere Forschung dient dem Verständnis der Interaktion von mikrochimären Zellen mit dem Wirt und zur Klärung der Fragen, wie die Toleranz von MC während der Schwangerschaft und postpartum bei Müttern gewährleistet und aufrecht erhalten werden kann, welche Auswirkungen MC auf die frühe Entwicklung von Föten hat und ob es während Krankheiten zum Zusammenbruch der Immuntoleranz kommt und welche Ursachen dies hat.", "en": "Microchimerism (MC) is the harboring of a small number of cells between two distinct individuals. This transfer of cells is well known to occur between mothers and offspring during gestation, though other avenues of transfer may be possible. The current understanding of MC is puzzling and little is known about the role microchimeric cells play in host physiology.\r\nWhy are the effects of MC paradoxical and what are the mechanisms responsible for maintaining microchimeric cells over an organism’s lifetime? Evolutionary biology and maternal-fetal conflict theory can provide a framework to understand the persistence of microchimeric cells, and how this may lead to disease vulnerability.\r\nWe hypothesize MC is much more common than previously reported and microchimeric cells play an adaptive role in host physiology, providing benefits for both mothers and offspring through transfers of stem and other cell types, and providing key immune system components and signals. However, in certain host tissues the maternal-fetal genetic interests may not align, potentially leading to disease vulnerability.\r\nWe aim to understand the role MC plays in health and disease, and understand the potential for and effects of subsequent generational transfers of microchimeric cells. We will use cutting edge technology to characterize MC cell distribution and trafficking between hosts and the effects of MC-host immune system interactions in various host tissues by creating a mouse Microchiome Atlas (Project 1), phenotyping human maternal MC (mMC) (Project 2), phenotyping human fetal MC (fMC) (Project 3), phenotyping microchimeric cells proximal and distal in terms of distance from the maternal-fetal interface as well as in various other organs (Project 4), and interrogating the context of MC and autoimmune disease in animal models (Project 5).\r\nOur research will determine how microchimeric cells interact with the host system to initiate and maintain tolerance of MC during pregnancy, the postpartum period for mothers and early development in offspring, and uncover if there is a breakdown in immune tolerance during disease states, and what causes it." }, "begin_planned": "2022-02-01T01:00:00+01:00", "begin_effective": "2021-12-01T01:00:00+01:00", "end_planned": "2024-10-31T01:00:00+01:00", "end_effective": "2026-08-30T02:00:00+02:00", "assignment": "2022-02-01T12:59:33+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 3, "manager": 54171, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2575 ], "funder_projectcode": "62214", "ethics_committee": null, "edudract_number": null, "persons": [ "6899-104057-12", "6899-54171-10", "6899-82600-12", "6899-104139-12", "6899-114270-12", "6899-115382-12", "6899-116463-12" ] }, { "id": 7717, "title": { "de": "Metrologie für Genomprofilerstellung zur Unterstützung der Krebsfrüherkennung und Präzisionsmedizin", "en": "Metrology for genomic profiling to support early cancer detection and precision medicine" }, "short": "GenomeMET", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-07-01T02:00:00+02:00", "begin_effective": "2023-09-01T02:00:00+02:00", "end_planned": "2027-06-30T02:00:00+02:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2023-08-10T15:15:02+02:00", "program": 239, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51870, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "22HLT06", "ethics_committee": null, "edudract_number": null, "persons": [ "7717-51870-10" ] } ] }