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GET /v1/research/project/?format=api&offset=1940&ordering=-end_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1960&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1920&ordering=-end_effective", "results": [ { "id": 2043, "title": { "de": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action", "en": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action" }, "short": "ORPHAN RECEPTOR GPR55", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-01-20T12:45:29+01:00", "program": 92, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1002, "title": { "de": "EuroSTEC: Soft tissue engineering for congenital birth defects in children: from \"biomatrix - cell interaction - model system\" to clinical trials", "en": "EuroSTEC: Soft tissue engineering for congenital birth defects in children: from \"biomatrix - cell interaction - model system\" to clinical trials" }, "short": "EuroSTEC", "url": null, "abstract": { "de": "The aim of this project is to use modern tissue engineering approaches to treat children with structural disorders present at birth, such as spina bifida, urogenital defects or abdominal wall defects and surrounding anomalies. The project strives to elucidate underlying mechanisms and take a translational route through in vitro and animal experiments.\r\nThis project will give more insight in the opportunities for advanced technical possibilities with tissue engineering techniques and new treatment strategies for severe and major structural congenital birth defects in children. \r\n", "en": "The aim of this project is to use modern tissue engineering approaches to treat children with structural disorders present at birth, such as spina bifida, urogenital defects or abdominal wall defects and surrounding anomalies. The project strives to elucidate underlying mechanisms and take a translational route through in vitro and animal experiments.\r\nThis project will give more insight in the opportunities for advanced technical possibilities with tissue engineering techniques and new treatment strategies for severe and major structural congenital birth defects in children. \r\n" }, "begin_planned": "2006-11-01T01:00:00+01:00", "begin_effective": "2007-01-01T01:00:00+01:00", "end_planned": "2011-10-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2007-01-15T14:22:41+01:00", "program": 21, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2788, "title": { "de": "Scanningbewegungen des Kopfes als Ausdruck des Schauverhaltens am gehenden Patienten im Low vision Bereich: Entwicklung der Analysemethode und Standardisierung", "en": "Headscanning in Mobility Testing" }, "short": "Headscanning in Mobility Testing", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-01T02:00:00+02:00", "begin_effective": "2011-05-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2012-02-14T15:16:48+01:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 938 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2341, "title": { "de": "Einzelzellanalyse in der forensischen Medizin", "en": "Single cell analysis in forensic medicine" }, "short": "Single cell analysis", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-05-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2011-04-30T02:00:00+02:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-11-17T11:21:30+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 54171, "contact": 54171, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2341-54171-10" ] }, { "id": 2460, "title": { "de": "Etablierung organtypischer Zellkultur für Herzgewebe", "en": "Establishing of organotypic cell culture for heart tissue" }, "short": "ORGANOTYPIC CELL CULTURE HEART TISSUE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-03-01T01:00:00+01:00", "begin_effective": "2011-05-01T02:00:00+02:00", "end_planned": "2011-08-31T02:00:00+02:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-04-07T13:19:02+02:00", "program": null, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2406, "title": { "de": "Adipokine Visfatin und Chemerin im Kindes- und Jugendalter", "en": "The adipokines visfatin and chemerin in childhood and adolescence" }, "short": "ADIPOKINE VISFATIN CHEMERIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-10-01T02:00:00+02:00", "begin_effective": "2011-03-01T01:00:00+01:00", "end_planned": "2011-10-01T02:00:00+02:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-02-15T12:46:08+01:00", "program": null, "subprogram": null, "organization": 14091, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2451, "title": { "de": "Ein US28/GNA Fusionsprotein zur Induktion der Apoptose beim Melanom", "en": "A US28/GNA Fusion Protein to Induce Apoptosis in Melanoma " }, "short": "US28/GNA and Melanoma", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-03-01T01:00:00+01:00", "begin_effective": "2011-04-01T02:00:00+02:00", "end_planned": "2011-05-31T02:00:00+02:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-03-23T11:47:48+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 53662, "contact": 53662, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2451-53662-10" ] }, { "id": 2457, "title": { "de": "INTEROCEPTION AND ARTERIAL STIFFNESS", "en": "INTEROCEPTION AND ARTERIAL STIFFNESS" }, "short": "STRESS HYPOXIC CONDITIONS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-04-01T02:00:00+02:00", "begin_effective": "2011-03-28T02:00:00+02:00", "end_planned": "2011-12-30T01:00:00+01:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-03-29T11:56:04+02:00", "program": null, "subprogram": null, "organization": 29447, "category": 10, "type": 10, "partner_function": 4, "manager": 60040, "contact": 60040, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2457-60040-10" ] }, { "id": 825, "title": { "de": "MPO-modifiziertes High-Density Lipoprotein und Rezeptoren", "en": "MPO-modified high-density lipoprotein and receptors" }, "short": "MPO-mod. HD LDL", "url": null, "abstract": { "de": "The vascular endothelium is a wide spread organ responsible for the regulation of hemodynamics, angiogenic vascular remodeling, metabolic, synthetic, antiinflammatory, and antithrombogenic processes. Diminished nitric oxide (NO) availability has been linked to vascular disease and a heightened state of inflammation is characterized, in part, by an increase in vascular myeloperoxidase and proteins in vivo modified by its principal oxidant, hypochlourous acid/hypochlorous acid/hypochlorite (HOCI/OCI). Modification of high-density lipoprotein (HDL) by HOCI generates a proatherogenic and proinflammatory lipoprotein particle. HOCI-HDL, present in human lesions material and on endothelial cells, attenuates the expression and activity of vasuloprotective endothelial NO synthase (eNOS). Therefore, one part of this application is to clarify the mechanisms that governs interaction of HODI-HDL and its lipid (plasmalogen)-derived oxidant 2-chlorohexadecanal with eNOS, to focus whether caveolae-located proteins are involved, to profile alterations in endothelial gene expression patterns, and to investigate endothelium-dependent vascular relaxation in aortic rings and perfused vessels. As endothelial dysfunction may be induced by receptor-ligand interaction, the other part of this application will focus on interaction of HOCI-HDL with candidate receptors mediating (patho)physiologically relevant cellualar responses, i.e. activation of transcription factors, kinases and production of cytokines, leadng to the perpetuation of the inflammatory response and endothelial dysfunction. To answer these questions cell lines overexpressing candidate receptors will be used before adapting the cellular signaling cascade patterns to a specific endothelial cell line. We propose that myeloperoxidase-modified HDL- a unique and clinically significant marker for atherosclerosis - mediates endothelial dysfunction by specific receptor-evoked intracellular signaling pathways. ", "en": "The vascular endothelium is a wide spread organ responsible for the regulation of hemodynamics, angiogenic vascular remodeling, metabolic, synthetic, antiinflammatory, and antithrombogenic processes. Diminished nitric oxide (NO) availability has been linked to vascular disease and a heightened state of inflammation is characterized, in part, by an increase in vascular myeloperoxidase and proteins in vivo modified by its principal oxidant, hypochlourous acid/hypochlorous acid/hypochlorite (HOCI/OCI). Modification of high-density lipoprotein (HDL) by HOCI generates a proatherogenic and proinflammatory lipoprotein particle. HOCI-HDL, present in human lesions material and on endothelial cells, attenuates the expression and activity of vasuloprotective endothelial NO synthase (eNOS). Therefore, one part of this application is to clarify the mechanisms that governs interaction of HODI-HDL and its lipid (plasmalogen)-derived oxidant 2-chlorohexadecanal with eNOS, to focus whether caveolae-located proteins are involved, to profile alterations in endothelial gene expression patterns, and to investigate endothelium-dependent vascular relaxation in aortic rings and perfused vessels. As endothelial dysfunction may be induced by receptor-ligand interaction, the other part of this application will focus on interaction of HOCI-HDL with candidate receptors mediating (patho)physiologically relevant cellualar responses, i.e. activation of transcription factors, kinases and production of cytokines, leadng to the perpetuation of the inflammatory response and endothelial dysfunction. To answer these questions cell lines overexpressing candidate receptors will be used before adapting the cellular signaling cascade patterns to a specific endothelial cell line. We propose that myeloperoxidase-modified HDL- a unique and clinically significant marker for atherosclerosis - mediates endothelial dysfunction by specific receptor-evoked intracellular signaling pathways. " }, "begin_planned": "2006-07-01T02:00:00+02:00", "begin_effective": "2006-12-16T01:00:00+01:00", "end_planned": "2009-06-30T02:00:00+02:00", "end_effective": "2011-12-15T01:00:00+01:00", "assignment": "2006-05-16T17:47:52+02:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51833, "contact": 51833, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P19074", "ethics_committee": null, "edudract_number": null, "persons": [ "825-51833-10" ] }, { "id": 1725, "title": { "de": "Role of T regulatory cells in polymorphic light eruption", "en": "Role of T regulatory cells in polymorphic light eruption" }, "short": "polymorphic light eruption", "url": null, "abstract": { "de": "Die polymorphe Lichtdermatose (PLD- \"Sonnenallergie\"), deren Prävalenz (mit bis zu 20%) vor allem bei jungen Frauen außerordentlich hoch ist, ist durch an sonnenexponierten Körperstellen auftretende, stark juckende Hautveränderungen gekennzeichnet. Die Ätiopathogenese der PLD ist unbekannt, eine Störung der UV-induzierten Immunsuppression mit Immunreaktionen gegen Photoneoantigene der Haut wird vermutet. Bei der Immunsuppression nach UV-EInwirkung kommt den regulatorischen T-Zellen (CD4+CD25+FoxP3+) (Tregs), einer Subpoulation der T-Helfer Zellen, eine bedeutende Rolle zu.\r\nIm vorliegenden Projekt soll die Hypothese geprüft werden, dass Tregs von PLD-Patienten pathogenetisch bedeutsam im Jahresverlauf abnormal fluktuierende Spiegel und Funktionen aufweisen, welche möglicherweise durch Photohardening (UV-Abhärtung) normalisierbar sind. Aus einem besseren Verständnis der Pathogenese der PLD könnten möglicherweise Ansätze für neue therapeutische Strategien resultieren.", "en": "Die polymorphe Lichtdermatose (PLD- \"Sonnenallergie\"), deren Prävalenz (mit bis zu 20%) vor allem bei jungen Frauen außerordentlich hoch ist, ist durch an sonnenexponierten Körperstellen auftretende, stark juckende Hautveränderungen gekennzeichnet. Die Ätiopathogenese der PLD ist unbekannt, eine Störung der UV-induzierten Immunsuppression mit Immunreaktionen gegen Photoneoantigene der Haut wird vermutet. Bei der Immunsuppression nach UV-EInwirkung kommt den regulatorischen T-Zellen (CD4+CD25+FoxP3+) (Tregs), einer Subpoulation der T-Helfer Zellen, eine bedeutende Rolle zu.\r\nIm vorliegenden Projekt soll die Hypothese geprüft werden, dass Tregs von PLD-Patienten pathogenetisch bedeutsam im Jahresverlauf abnormal fluktuierende Spiegel und Funktionen aufweisen, welche möglicherweise durch Photohardening (UV-Abhärtung) normalisierbar sind. Aus einem besseren Verständnis der Pathogenese der PLD könnten möglicherweise Ansätze für neue therapeutische Strategien resultieren." }, "begin_planned": "2009-01-01T01:00:00+01:00", "begin_effective": "2009-01-01T01:00:00+01:00", "end_planned": "2010-12-31T01:00:00+01:00", "end_effective": "2011-11-30T01:00:00+01:00", "assignment": "2009-01-16T14:41:21+01:00", "program": 79, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 51618, "contact": 51618, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1725-54011-12", "1725-51618-10" ] }, { "id": 2607, "title": { "de": "Die Rolle der Phospholipid-Scramblase 1 (PLSCR1) in der Differenzierung und Fusion von humanen Trophoblasten ", "en": "The role of Phospholipid-Scramblase 1 (PLSCR1) in human trophoblast differentiation and fusion" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-13T02:00:00+02:00", "begin_effective": "2011-05-13T02:00:00+02:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2011-11-30T01:00:00+01:00", "assignment": "2011-10-05T11:53:24+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 53232, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2607-53232-10" ] }, { "id": 1302, "title": { "de": "Cardiac Conduction and Microstructure in the Right Atrial Isthmus", "en": "Cardiac Conduction and Microstructure in the Right Atrial Isthmus" }, "short": "VORHOFFLIMMERN_FWF", "url": null, "abstract": { "de": "Vorhofflimmern und Vorhofflattern sind Erkrankungen, deren Inzidenz in hohem Alter um ein vielfaches zunimmt. In USA sind derzeit 6% der Bevölkerung über 65 Jahre davon betroffen. Die Erforschung atrialer Erregungsleitung unter besonderer Berücksichtigung der altersbedingten Mikrostrukturveränderungen des Myokards verdient daher besondere Beachtung. Aus klinischer Sicht wird u.a. der postero-laterale Isthmus des rechten Atriums als kritisches Substrat für die Entstehung von intermittierendem Leitungblock angesehen. Diese Zone besteht aus einem komplexen Netzwerk kabelförmiger Faserbündel (Musculi Pectinati), welche die Crista Terminalis und das Vestibulum verbinden. \r\nNeuere Untersuchungen der Bindegewebsmatrix im Atrium Gewebe lassen die Vermutung zu, dass in detailliert mikroskopischer Sicht (Submillimeterbereich) Erregungsausbreitung nicht so verläuft, wie in makroskopischen intrakardialen Verfahren abgebildet. Da klinische Messverfahren auch in absehbarer Zukunft diese hohe räumliche Auflösung nicht erwarten lassen, sind in-vitro Experimente am isolierten Kleintierherz mit ultra-hochauflösenden Verfahren zweckdienlich und geplant. Ein derartiges System wurde von unserer Forschergruppe entwickelt. Es ermöglicht das Erfassen des elektrischen Nah-Feldes (CNF = cardiac near field) an der Gewebsoberfläche durch vier Elektroden innerhalb von 50x50 µm und in einer Entfernung von 60 µm und kann dieses als zweidimensionales Signal (Vektorschleife) mit exzellenter Signalqualität aufzeichnen. Betrag und Richtung der lokalen Ausbreitungsgeschwindigkeit sowie kleinste Signallatenzen im Bereich von wenigen Mikrosekunden können ermittelt werden. Somit werden Diskontinuitäten der Erregungsausbreitung, verursacht durch (oft nur durch Bruchteile eines Millimeters getrennte) Bindegewebseinlagerungen detektierbar. Durch gezielte individuelle Positionierung von bis zu 5 nadelförmigen Nahfeld-Sensoren und simultane Erfassung der kardialen Nahfelder speziell im Bereich von Verzweigungen oder Einmündungen von dünnen Muskelfasern kann man eine Aufklärung sowohl der makroskopischen als auch der mikroskopischen Leitungsmechanismen in diesem Faserbündelnetz des Isthmus erwarten. \r\nZiel des Projektes ist es, Makro- und Mikroerregungsaubreitung an kritischen Zonen des Vorhofs zu messen und zu analysieren, und zwar mit einer bisher unerreichten Auflösung in Raum (50µm) und Zeit (5µs). Um dieses Ziel zu erreichen, benötigen wir vier Komponenten: 1. die Erstellung einer detaillierten elektro-anatomischen Karte des Isthmus mit einer Zuordnung der leitungsrelevanten Parameter (Größe und Richtung der Ausbreitungsgeschwindigkeit sowie deren Komplexität). 2. Histologische Schnitte zur Bestimmung des Verlaufs von Faserrichtung, Bindegewebsstrukturen und der Topologie der zwischenzellulären Spalte. 3. Bildverabeitung von histologischen Schnitten zur Konstruktion von 3D-Leitungsmodellen und 4. Simulation der Erregungsausbreitung im Gewebsstrukturmodell. Mit einem derartigen Modell kann das elektrophysiologische Experiment validiert werden und vice versa. \r\nEin breiter interdisziplinärer Ansatz mit Einsatz modernster Verfahren aus Signalverarbeitung, Bildverarbeitung, Messtechnik und Sensorik, Histologie und Computersimulation lässt neue Erkenntnisse um die Mechanismen von Vorhofflimmern und flattern erwarten. In weiterer Zukunft könnten derartige mikrostrukturrelevante Analysen aus dem Nahfeldsignal auch für die klinische Anwendung in minimal-invasiver Kathetertechnik relevant werden. \r\n", "en": "Severe atrial conduction disturbances, namely atrial flutter and atrial fibrillation are associated with aging. In USA atrial fibrillation nowadays affects 6 % of the population elder than 65 years, a fraction rising steady with increasing life expectancy. Research on atrial conduction comprising functional and structural aspects associated ageing is therefore of particular interest. \r\nThe lateral and posterior part of the lower right atrium is seen as critical substrate for the genesis of intermittent block of conduction. This region of interest (ROI) forms a network of cable-like muscle bundles comprising the terminal ramifications of the terminal crest, pectinate muscles and the tricuspidal valve vestibule. \r\nRecent studies on the tissue matrix in several regions of the atria suggest, that excitation spread at a sub-millimetre size scale may differ substantially from activation maps taken from clinical recordings at a coarser size scale. However clinical mapping systems capable of resolving activation sequences in the sub-millimetre range will not be available in the foreseeable future. Ultra-high resolution techniques, like the Cardiac Near Field (CNF) recording developed recently by our group, are ideally suited to study macro- as well as micro-propagation of the cardiac impulse in the ROI. CNF-analysis allows the determination of magnitude and direction of conduction velocity as well as the detection of complex discontinuities of conduction within an observation area of much less than 1 mm². From such high-resolution recordings taken simultaneously at 5 individual sites one can get details of conduction along an individual muscle fibre or specifically in zones where fibres branch or merge. Complex conduction caused by recurrent thin (some tens of microns) barriers formed by connective tissue can be detected by this new technique. \r\nThe aim of the project is to study and compare mechanisms of macro- and micro-propagation in the ROI and to develop a structure-related computer model of this atrial zone with spatio-temporal resolution unknown until know. Four components of knowledge about the ROI are needed to reach this goal: 1. a detailed electro-anatomical map of signals reflecting magnitude and direction of local conduction velocity as well as an index of microstructural complexity 2. histological images revealing the course and the topology of conducting fibers, of connective tissue and of interstitial clefts. 3. methods of image processing to convert these images into microgrids of conduction parameters related to the histograph 4. methods to assemble these data to a structure related computer model. Validation of the virtual tissue model can be made by electrophysiological experiments and vice versa. Only a broad multidisciplinary view comprising histology, image analysis, measurement technique, signal processing, computer simulation and cardiac electrophysiology will let us achieve these goals. The scientists involved in this project will ensure this approach by cooperation established yet. The results should push forward the knowledge of microstructure related conduction disturbances, particularly in the Isthmus of the right atrium. A profound analysis of the signature of microstructure in CNF-signals will open new aspects of diagnostic tools of arrhythmia analysis for future minimal-invasive catheter techniques. \r\n" }, "begin_planned": "2007-07-01T02:00:00+02:00", "begin_effective": "2007-07-01T02:00:00+02:00", "end_planned": "2010-06-30T02:00:00+02:00", "end_effective": "2011-10-31T01:00:00+01:00", "assignment": "2007-06-13T17:49:54+02:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 51502, "contact": 51502, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P19993", "ethics_committee": null, "edudract_number": null, "persons": [ "1302-50966-12", "1302-58963-12", "1302-51753-12", "1302-50126-12", "1302-51502-10" ] }, { "id": 2327, "title": { "de": "Vollkeramische Sofortversorgung einteiliger Zirkonoxidimplantate", "en": "All ceramic immediate provisional restoration of Circonia single-peace implants" }, "short": "Vollkeramische Sofortversorgung", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2011-10-31T01:00:00+01:00", "assignment": "2010-10-13T13:26:05+02:00", "program": null, "subprogram": null, "organization": 14057, "category": 10, "type": 10, "partner_function": 1, "manager": 50792, "contact": 50792, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2327-50792-10" ] }, { "id": 2631, "title": { "de": "Parakriner Effekt von mesenchymalen Stammzellen der Plazenta auf die Funktion von Endothelzellen", "en": "Paracrine effects of placental mesenchymal stem cells on endothelial cell function" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-06-01T02:00:00+02:00", "begin_effective": "2011-06-01T02:00:00+02:00", "end_planned": "2011-10-31T01:00:00+01:00", "end_effective": "2011-10-31T01:00:00+01:00", "assignment": "2011-11-09T12:45:09+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 51718, "contact": 51718, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2631-51718-10" ] }, { "id": 2329, "title": { "de": "Doktoratskolleg \"Metabolische und Kardiovaskuläre Erkrankungen\"", "en": "\"Metabolic and Cardiovascular disease\"" }, "short": "DK-MCD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-05-01T02:00:00+02:00", "begin_effective": "2010-05-01T02:00:00+02:00", "end_planned": "2014-06-30T02:00:00+02:00", "end_effective": "2011-09-30T02:00:00+02:00", "assignment": "2010-10-20T13:08:26+02:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 51691, "contact": 51691, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": "W1226", "ethics_committee": null, "edudract_number": null, "persons": [ "2329-51691-10" ] }, { "id": 2266, "title": { "de": "Mikropellets für genderspezifische Medikation", "en": "Mikropellets für genderspezifische Medikation" }, "short": "MIKROPELLETS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-04-01T02:00:00+02:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2011-09-30T02:00:00+02:00", "end_effective": "2011-09-30T02:00:00+02:00", "assignment": "2010-08-16T16:53:15+02:00", "program": null, "subprogram": "FemTech FTI-Projekt", "organization": 28394, "category": 10, "type": 10, "partner_function": 2, "manager": 53900, "contact": 53900, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2266-53900-10" ] }, { "id": 2165, "title": { "de": "\"Blauer LASER\" in der Akupunktur-Weltweit erste wissenschaftliche Untersuchungen am interuniversitären TCM Forschungszentrum Graz", "en": "\"Blauer LASER\" in der Akupunktur-Weltweit erste wissenschaftliche Untersuchungen am interuniversitären TCM Forschungszentrum Graz" }, "short": "Blauer LASER", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2011-06-30T02:00:00+02:00", "end_effective": "2011-09-30T02:00:00+02:00", "assignment": "2010-03-29T18:06:01+02:00", "program": null, "subprogram": null, "organization": 14044, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2074, "title": { "de": "Gamma Knife Radiochirurgie zur Behandlung des malignen Melanoms der Aderhaut - eine multizentrische randomisierte prospektive Studie", "en": "Gamma Knife Radiochirurgie zur Behandlung des malignen Melanoms der Aderhaut - eine multizentrische randomisierte prospektive " }, "short": "Gamma Knife Radiochirurgie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-10-01T02:00:00+02:00", "begin_effective": "2009-10-01T02:00:00+02:00", "end_planned": "2011-09-30T02:00:00+02:00", "end_effective": "2011-09-30T02:00:00+02:00", "assignment": "2010-02-02T16:33:12+01:00", "program": null, "subprogram": "Land Steiermark Projekt über5.000,- Euro", "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1580, "title": { "de": "Albumin an acute-on-chronic liver failure: more than just volume? A randomized, controlled study", "en": "Albumin an acute-on-chronic liver failure: more than just volume? A randomized, controlled study" }, "short": "LIVER_FAILURE", "url": null, "abstract": { "de": "Acute-on-chronic liver failure (ACLF) often results in multiple organ dysfunction and mortality rates are in the order of 50-90%.\r\nAlbumin is the major plasma protein and is produced in the liver. Albumin undertakes a variety of functions including: fatty acid transport; metal chelation; drug-binding; and anti-oxidant activity. In liver disease its concentration is diminished but the mechanism of this reduction is uncertain. Currently, albumin infusion in patients with cirrhosis is used primarily as a volume expander. However, recent studies showing reduction in severity of hepatic encephalopathy and improved survival of cirrhotic patients with spontaneous bacterial peritonitis and hepatorenal syndrome treated with albumin infusion is compelling.\r\nOne of the substances that bind to albumin is endotoxin. Endotoxin is a lipopolysaccharid derived from the wall of gram-negative bacteria that causes immediate and strong immune response.\r\n\r\nWe hypothesize that infusion of albumin can improve endotoxin binding capacity and thereby prevent inappropriate neutrophil activation and neutrophil dysfunction in patients with spontaneous bacterial peritonitits. Therefore we aim to investigate neutrophil function (oxidative burst and phagocytosis) and endotoxin binding capacity as well as albumin function in patients with spontaneous bacterial peritonitis before, during and after high-dose albumin infusions as compared to standard therapy. We will also record the occurence of organ failure as a clinical endpoint.", "en": "Acute-on-chronic liver failure (ACLF) often results in multiple organ dysfunction and mortality rates are in the order of 50-90%.\r\nAlbumin is the major plasma protein and is produced in the liver. Albumin undertakes a variety of functions including: fatty acid transport; metal chelation; drug-binding; and anti-oxidant activity. In liver disease its concentration is diminished but the mechanism of this reduction is uncertain. Currently, albumin infusion in patients with cirrhosis is used primarily as a volume expander. However, recent studies showing reduction in severity of hepatic encephalopathy and improved survival of cirrhotic patients with spontaneous bacterial peritonitis and hepatorenal syndrome treated with albumin infusion is compelling.\r\nOne of the substances that bind to albumin is endotoxin. Endotoxin is a lipopolysaccharid derived from the wall of gram-negative bacteria that causes immediate and strong immune response.\r\n\r\nWe hypothesize that infusion of albumin can improve endotoxin binding capacity and thereby prevent inappropriate neutrophil activation and neutrophil dysfunction in patients with spontaneous bacterial peritonitits. Therefore we aim to investigate neutrophil function (oxidative burst and phagocytosis) and endotoxin binding capacity as well as albumin function in patients with spontaneous bacterial peritonitis before, during and after high-dose albumin infusions as compared to standard therapy. We will also record the occurence of organ failure as a clinical endpoint." }, "begin_planned": "2008-04-01T02:00:00+02:00", "begin_effective": "2008-10-01T02:00:00+02:00", "end_planned": "2010-03-31T02:00:00+02:00", "end_effective": "2011-09-30T02:00:00+02:00", "assignment": "2008-07-16T16:58:47+02:00", "program": 79, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 50989, "contact": 50989, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1580-50989-10" ] }, { "id": 1543, "title": { "de": "Expression und Lokalisierung der Endothel Lipase in stabilen und unstabilen atherosklerotischen Plaques", "en": "Expression and localization of endothelial lipase in stable and unstable atherosclerotic plaques" }, "short": "EXPRESS_LOKALIS_ENDOTHEL_LIPASE", "url": null, "abstract": { "de": "Atherosklerose im Bereich der Karotiden ist Hauptverursacher des Schlaganfalles, einer der häufigsten Invaliditäts- und Todesursachen in den westlichen Industrieländern. Das Auftreten von neurologischen Symptomen bei betroffenen Patienten geht mit der Destabilisierung der atherosklerotischen Plaques einher. Da die Endothel Lipase in den Plaque-assoziierten Zellen exprimiert wird, wollen wir im Rahmen des beantragten Projektes untersuchen ob sich die Expressionsrate und die zellspezifische Lokalisierung der Endothel Lipase zwischen stabilen und unstabilen atherosklerotischen Plaques von Patienten nach operativer Endarterektomie unterscheidet. Die Ergebnisse dieser Studie versprechen neue Erkenntnisse über die Rolle von Endothel Lipase in der Entwicklung und Destabilisierung von karotidalen atherosklerotischen Plaques und stellen die Basis für die Entwicklung neuer Medikamente zur Prävention von Plaque-Destabilisierung dar.", "en": "Atherosklerose im Bereich der Karotiden ist Hauptverursacher des Schlaganfalles, einer der häufigsten Invaliditäts- und Todesursachen in den westlichen Industrieländern. Das Auftreten von neurologischen Symptomen bei betroffenen Patienten geht mit der Destabilisierung der atherosklerotischen Plaques einher. Da die Endothel Lipase in den Plaque-assoziierten Zellen exprimiert wird, wollen wir im Rahmen des beantragten Projektes untersuchen ob sich die Expressionsrate und die zellspezifische Lokalisierung der Endothel Lipase zwischen stabilen und unstabilen atherosklerotischen Plaques von Patienten nach operativer Endarterektomie unterscheidet. Die Ergebnisse dieser Studie versprechen neue Erkenntnisse über die Rolle von Endothel Lipase in der Entwicklung und Destabilisierung von karotidalen atherosklerotischen Plaques und stellen die Basis für die Entwicklung neuer Medikamente zur Prävention von Plaque-Destabilisierung dar." }, "begin_planned": "2008-10-01T02:00:00+02:00", "begin_effective": "2008-10-01T02:00:00+02:00", "end_planned": "2011-09-30T02:00:00+02:00", "end_effective": "2011-09-30T02:00:00+02:00", "assignment": "2008-05-29T11:09:47+02:00", "program": 79, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51988, "contact": 51988, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1543-51988-10" ] } ] }