Project List
List projects.
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begin_planned:gt,gte,lt,ltebegin_effective:gt,gte,lt,lteend_planned:gt,gte,lt,lteend_effective:gt,gte,lt,lte
GET /v1/research/project/?format=api&offset=1900&ordering=-end_planned
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1920&ordering=-end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1880&ordering=-end_planned", "results": [ { "id": 2457, "title": { "de": "INTEROCEPTION AND ARTERIAL STIFFNESS", "en": "INTEROCEPTION AND ARTERIAL STIFFNESS" }, "short": "STRESS HYPOXIC CONDITIONS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-04-01T02:00:00+02:00", "begin_effective": "2011-03-28T02:00:00+02:00", "end_planned": "2011-12-30T01:00:00+01:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-03-29T11:56:04+02:00", "program": null, "subprogram": null, "organization": 29447, "category": 10, "type": 10, "partner_function": 4, "manager": 60040, "contact": 60040, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2457-60040-10" ] }, { "id": 2438, "title": { "de": "Genvarianten in den RAD51-, XRCC2-, XRCC3-, XPD- und XPG-Genen als Prädiktionsfaktoren für Metastasierung bei PatientInnen mit Weichteilsarkomen", "en": "Genetic variants in the RAD51, XRCC2, XRCC3, XPD and XPG genes as predictors of outcome in soft tissue sarcoma patients" }, "short": "SOFT TISSUE SARCOMA PATIENTS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-12-01T01:00:00+01:00", "begin_effective": "2011-04-01T02:00:00+02:00", "end_planned": "2011-12-01T01:00:00+01:00", "end_effective": "2012-03-30T02:00:00+02:00", "assignment": "2011-03-03T12:10:08+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 69234, "contact": 69234, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2438-69234-10", "2438-58814-12" ] }, { "id": 2568, "title": { "de": "Akustisches Interface zur Tremoranalyse", "en": "Acoustic interface for tremoranalysis" }, "short": "ACOUSTIC INTERFACE TREMORANALYSIS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-01T02:00:00+02:00", "begin_effective": "2011-09-01T02:00:00+02:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2012-10-31T01:00:00+01:00", "assignment": "2011-09-06T12:41:59+02:00", "program": null, "subprogram": "Forschung Steiermark - Planung, Steuerung, Impulse\r\nHTI", "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1735, "title": { "de": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 8: Lipid droplet-associated proteins regulating lipid storage and release in macrophages and foam cells", "en": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 8: Lipid droplet-associated proteins regulating lipid storage and release in macrophages and foam cells" }, "short": "GOLD3_KRATKY", "url": null, "abstract": { "de": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.", "en": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis." }, "begin_planned": "2008-12-01T01:00:00+01:00", "begin_effective": "2009-02-01T01:00:00+01:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2009-01-22T11:56:26+01:00", "program": 73, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51904, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1735-51904-10", "1735-58794-11" ] }, { "id": 1714, "title": { "de": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling", "en": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling" }, "short": "GOLD3_BIRNER_GRUENBERGER", "url": null, "abstract": { "de": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.", "en": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis." }, "begin_planned": "2008-12-01T01:00:00+01:00", "begin_effective": "2009-02-01T01:00:00+01:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2009-01-14T12:15:11+01:00", "program": 73, "subprogram": null, "organization": 28394, "category": 10, "type": 10, "partner_function": 2, "manager": 58794, "contact": 58794, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1714-58794-10" ] }, { "id": 2504, "title": { "de": "Subtyp-spezifische, nicht kompetitive metabotrope Glutamatrezeptor-1 Antoagonisten als neuer alternativer Therapieansatz bei neuroendokrinen Tumoren", "en": "Subtype-specific, non competitive metabotropic glutamatereceptor-1 antagonists as novel alternative therapeutic option for neuroendocrine tumors" }, "short": "glutamate-receptor-1 antagonists", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2012-01-31T01:00:00+01:00", "assignment": "2011-06-21T11:36:12+02:00", "program": null, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2496, "title": { "de": "Einfluss mechanischer Belastung auf die Expression von Matrix Metalloproteasen in Knorpelzellen aus der kindlichen Wachstumsfuge", "en": "Influence of mechanical strain on the expression of Matrix Metalloproteases in chondrocytes from the infant growth plate" }, "short": "KINDLICHE WACHSTUMSFUGE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-06-01T02:00:00+02:00", "begin_effective": "2011-06-01T02:00:00+02:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2012-02-28T01:00:00+01:00", "assignment": "2011-06-10T12:21:53+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2607, "title": { "de": "Die Rolle der Phospholipid-Scramblase 1 (PLSCR1) in der Differenzierung und Fusion von humanen Trophoblasten ", "en": "The role of Phospholipid-Scramblase 1 (PLSCR1) in human trophoblast differentiation and fusion" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-13T02:00:00+02:00", "begin_effective": "2011-05-13T02:00:00+02:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2011-11-30T01:00:00+01:00", "assignment": "2011-10-05T11:53:24+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 53232, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2607-53232-10" ] }, { "id": 2403, "title": { "de": "Maßgeschneiderte Therapien für Chordome: Bietet IGF-IR-Targeting neue Behandlungsoptionen?", "en": "Targeted Therapies for Chordomas: Does IGF-IR-Targeting Provide New Treatment Options?" }, "short": "Chordoma Targeted Therapies", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-11-01T01:00:00+01:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2011-11-01T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2011-02-09T14:17:52+01:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 1, "manager": 50448, "contact": 50448, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1091 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2403-50448-10" ] }, { "id": 2631, "title": { "de": "Parakriner Effekt von mesenchymalen Stammzellen der Plazenta auf die Funktion von Endothelzellen", "en": "Paracrine effects of placental mesenchymal stem cells on endothelial cell function" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-06-01T02:00:00+02:00", "begin_effective": "2011-06-01T02:00:00+02:00", "end_planned": "2011-10-31T01:00:00+01:00", "end_effective": "2011-10-31T01:00:00+01:00", "assignment": "2011-11-09T12:45:09+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 51718, "contact": 51718, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2631-51718-10" ] }, { "id": 2553, "title": { "de": "Der Einfluss von Dexamethason auf rheumatoide Synoviozyten untersucht anhand einer Gen Chip Transkriptionsanalyse", "en": "The Influence of Dexamethasone on Rheumatoid Fibroblast-Like Synoviocytes based on a Gene CHip Transcription Analysis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-01T02:00:00+02:00", "begin_effective": "2011-08-09T02:00:00+02:00", "end_planned": "2011-10-31T01:00:00+01:00", "end_effective": "2012-03-30T02:00:00+02:00", "assignment": "2011-08-10T10:28:02+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2505, "title": { "de": "Assoziation von Vitamin-D-Rezeptor-Genvarianten mit der Prognose des Kolonkarzinoms", "en": "Association of vitamin D receptor gene variants with colon cancer prognosis" }, "short": "VITAMIN D RECEPTOR COLON CANCER", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-11-01T01:00:00+01:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2011-10-31T01:00:00+01:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2011-06-21T11:36:47+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 69234, "contact": 69234, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2505-69234-10", "2505-58814-12" ] }, { "id": 2414, "title": { "de": "Rolle des enterischen Nervensystems (ENS) auf die Chemotaxis von Leukozyten in der Entzuendung", "en": "Chemoattraction of leukocytes by the enteric nervous system (ENS) during inflammation" }, "short": "CHEMOATTR_LEUKOCYTES_ENS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-11-01T01:00:00+01:00", "begin_effective": "2011-03-01T01:00:00+01:00", "end_planned": "2011-10-31T01:00:00+01:00", "end_effective": "2012-02-28T01:00:00+01:00", "assignment": "2011-02-17T09:32:46+01:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 56687, "contact": 56687, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2414-56687-10" ] }, { "id": 1002, "title": { "de": "EuroSTEC: Soft tissue engineering for congenital birth defects in children: from \"biomatrix - cell interaction - model system\" to clinical trials", "en": "EuroSTEC: Soft tissue engineering for congenital birth defects in children: from \"biomatrix - cell interaction - model system\" to clinical trials" }, "short": "EuroSTEC", "url": null, "abstract": { "de": "The aim of this project is to use modern tissue engineering approaches to treat children with structural disorders present at birth, such as spina bifida, urogenital defects or abdominal wall defects and surrounding anomalies. The project strives to elucidate underlying mechanisms and take a translational route through in vitro and animal experiments.\r\nThis project will give more insight in the opportunities for advanced technical possibilities with tissue engineering techniques and new treatment strategies for severe and major structural congenital birth defects in children. \r\n", "en": "The aim of this project is to use modern tissue engineering approaches to treat children with structural disorders present at birth, such as spina bifida, urogenital defects or abdominal wall defects and surrounding anomalies. The project strives to elucidate underlying mechanisms and take a translational route through in vitro and animal experiments.\r\nThis project will give more insight in the opportunities for advanced technical possibilities with tissue engineering techniques and new treatment strategies for severe and major structural congenital birth defects in children. \r\n" }, "begin_planned": "2006-11-01T01:00:00+01:00", "begin_effective": "2007-01-01T01:00:00+01:00", "end_planned": "2011-10-31T01:00:00+01:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2007-01-15T14:22:41+01:00", "program": 21, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2338, "title": { "de": "Genomic changes in the liver in ageing population: impact on metabolism and hepatocellualar carcinoma ", "en": "Genomic changes in the liver in ageing population: impact on metabolism and hepatocellualar carcinoma " }, "short": "AgedLiver", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-10-25T02:00:00+02:00", "begin_effective": "2010-10-25T02:00:00+02:00", "end_planned": "2011-10-24T02:00:00+02:00", "end_effective": "2010-12-31T01:00:00+01:00", "assignment": "2010-11-11T12:26:50+01:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": 51663, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 25 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2338-51663-10" ] }, { "id": 2397, "title": { "de": "Körperliche Aktivität, Fitness und Hirnaltern ", "en": "Physical activity, fitness and brain aging" }, "short": "FITNESS AND BRAIN AGING", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-05-01T02:00:00+02:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2011-10-20T02:00:00+02:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2011-02-07T14:46:33+01:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51912, "contact": 51912, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2397-51912-10" ] }, { "id": 2614, "title": { "de": "Mechanismen der Kalzium-getriggerten Arrhythmien", "en": "Mechanisms of Ca2+-triggered arrhythmias" }, "short": "Buchkapitel", "url": null, "abstract": { "de": null, "en": "Calcium (Ca2+) - the simplest and most versatile intracellular messenger - couples an action potential with the contraction in cardiac myocytes. Abnormal changes in intracellular Ca2+ homeostasis may cause contractile dysfunction, subcellular Ca2+ alternans and oscillations of the myocyte membrane potential, such as early afterdepolarizations (EADs) and delayed afterdepolarizations (DADs), both of which may evoke a number of triggered arrhythmias that cause sudden cardiac death. EAD occurs during excessive action potential prolongation mainly due to the reactivation of L-type Ca2+ channels. DAD, on the other hand, typically results from the increased diastolic SR Ca2+ release, which is caused by either defective regulation of the sarcoplasmic reticulum (SR) Ca2+ release channel (ryanodine receptor, RyR2), increased SR Ca2+ load or a combination of both. Sufficient cytosolic Ca2+ elevation propagates along myocytes as Ca2+ waves, which may activate an arrhythmogenic depolarizing current largely carried by inward Na+/Ca2+ exchanger. DADs need to reach threshold potential for voltage-gated Na+ channels to evoke premature beats (ectopic activity). Ca2+-dependent triggered arrhythmias occur both in acquired (e.g. heart failure, atrial fibrillation) and in congenital cardiac diseases (e.g. cathecholaminergic polymorphic ventricular tachycardia, CPVT). CPVT is an inherited arrhythmia syndrome associated with mutations in either RyR2 or calsequestrin, SR Ca2+-binding protein. Both mutations destabilize the RyR2 Ca2+ release complex implying increased diastolic SR Ca2+ leak through RyR2 in the presence of beta-adrenergic stimulation (e.g. physical exercise or emotional stress). Several mechanisms underlying the increased diastolic Ca2+ leak in heart failure and CPVT have been proposed, including excessive RyR2 phosphorylation, altered Ca2+ sensitivity of the RyR2 at luminal or cytosolic sites, weaker interdomain interaction and lower threshold for store-overload-induced Ca2+ release. A better understanding of the similarities and differences between the mechanisms underlying triggered arrhythmias in acquired and inherited cardiac diseases, holds the promise to develop new specific diagnostic and therapeutic approaches for effective treatment of defective ion handling in these lethal arrhythmias. \r\nThis chapter will review common mechanisms that cause the susceptibility to, and initiation of, Ca2+-dependent arrhythmias with a focus on increased SR Ca2+ release due to congenital or acquired RyR2 dysfunction and increased SR Ca2+ load. Finally, RyR2 stabilizers (e.g. JTV-519, flecainide, dantrolene) and RyR2 phosphorylation inhibitors (e.g. CaMKII inhibitors) as novel therapeutic targets will be discussed. \t\t\r\n" }, "begin_planned": "2011-06-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2011-10-15T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2011-10-14T16:07:01+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 60041, "contact": 60041, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2614-60041-10" ] }, { "id": 2406, "title": { "de": "Adipokine Visfatin und Chemerin im Kindes- und Jugendalter", "en": "The adipokines visfatin and chemerin in childhood and adolescence" }, "short": "ADIPOKINE VISFATIN CHEMERIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-10-01T02:00:00+02:00", "begin_effective": "2011-03-01T01:00:00+01:00", "end_planned": "2011-10-01T02:00:00+02:00", "end_effective": "2011-12-30T01:00:00+01:00", "assignment": "2011-02-15T12:46:08+01:00", "program": null, "subprogram": null, "organization": 14091, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2529, "title": { "de": "Untersuchung der MMP Expression in der humanen Chordomzellinie MUG-Chor 1", "en": "MMP Expression Analysis on the Human Chordoma Cell Line MUG-Chor 1" }, "short": "MMP EXPRESSION ANALYSIS_CHORDOMA CELL", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-06-01T02:00:00+02:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2011-10-01T02:00:00+02:00", "end_effective": "2012-02-28T01:00:00+01:00", "assignment": "2011-07-14T11:48:32+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50696, "contact": 50696, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2529-50696-10" ] }, { "id": 1640, "title": { "de": "Effect of ivabradine, a novel If-blocker, on human atrial myocytes under elevated endotoxin levels", "en": "Effect of ivabradine, a novel If-blocker, on human atrial myocytes under elevated endotoxin levels" }, "short": "IVABRADINE_FWF08", "url": null, "abstract": { "de": "Endotoxine (Lipopolysaccharide, LPSe), die Auslöser von gram-negativer Sepsis, führen durch Interaktion mit den Wirtszellen zu einer Vielzahl von biologischen Reaktionen. Kürzlich konnten wir in einer Publikation zeigen, dass LPS den Schrittmacherstrom If in humanen Vorhofzellen, nach 6-stündiger Inkubation hemmt, ein Ereignis, das für das Verständnis der bei Sepsis auftretenden Reduktion der Herzfrequenzvariabilität von großer Relevanz ist.\r\nAusgehend von der hemmenden LPS-Wirkung auf If sollen 2 große Themenschwerpunkte untersucht werden:\r\n*Interaktion von Ivabradine und Endotoxin auf den humanen If\r\n*Mechanismus der Endotoxinwirkung", "en": "Endotoxine (Lipopolysaccharide, LPSe), die Auslöser von gram-negativer Sepsis, führen durch Interaktion mit den Wirtszellen zu einer Vielzahl von biologischen Reaktionen. Kürzlich konnten wir in einer Publikation zeigen, dass LPS den Schrittmacherstrom If in humanen Vorhofzellen, nach 6-stündiger Inkubation hemmt, ein Ereignis, das für das Verständnis der bei Sepsis auftretenden Reduktion der Herzfrequenzvariabilität von großer Relevanz ist.\r\nAusgehend von der hemmenden LPS-Wirkung auf If sollen 2 große Themenschwerpunkte untersucht werden:\r\n*Interaktion von Ivabradine und Endotoxin auf den humanen If\r\n*Mechanismus der Endotoxinwirkung" }, "begin_planned": "2008-10-01T02:00:00+02:00", "begin_effective": "2009-10-01T02:00:00+02:00", "end_planned": "2011-09-30T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2008-10-13T14:02:42+02:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 50615, "contact": 50615, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P21159", "ethics_committee": null, "edudract_number": null, "persons": [ "1640-50615-10", "1640-50417-12", "1640-50969-12", "1640-51592-12" ] } ] }