Project List
List projects.
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The following relational fields can be expanded:
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GET /v1/research/project/?format=api&offset=1880&ordering=-end_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1900&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1860&ordering=-end_effective", "results": [ { "id": 2039, "title": { "de": "Wilms Tumor Development as a Mirror of Nephrogenesis - The Role of Imprinted Genes", "en": "Wilms Tumor Development as a Mirror of Nephrogenesis - The Role of Imprinted Genes" }, "short": "WILMS TUMOR NEPHROGENESIS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-02-01T01:00:00+01:00", "begin_effective": "2010-02-01T01:00:00+01:00", "end_planned": "2012-01-31T01:00:00+01:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2010-01-18T10:41:24+01:00", "program": 79, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 52569, "contact": 52569, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2039-52569-10" ] }, { "id": 1992, "title": { "de": "Laserakupunktur als unterstützende Therapie beim Neugeborenen mit Entzugssyndrom aufgrund mütterlicher Substitutionstherapie", "en": "Laserakupunktur als unterstützende Therapie beim Neugeborenen mit Entzugssyndrom aufgrund mütterlicher Substitutionstherapie" }, "short": "LASERAKUP_NEUGEB_ENTZUG", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-07-01T02:00:00+02:00", "begin_effective": "2009-07-01T02:00:00+02:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2009-11-26T15:43:39+01:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2620, "title": { "de": "Etablierung des Mutationsspektrums in zirkulierenden Tumorzellen von Patienntinnen und Patienten mit Mamma- oder Prostatakarzinomen _ONCOTYROL", "en": "Establishment of the mutation spectrum in circulating tumor cells of patients with breast and prostate cancer" }, "short": "ONCOTYROL", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-09-01T02:00:00+02:00", "begin_effective": "2010-09-01T02:00:00+02:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2011-10-28T13:07:04+02:00", "program": 94, "subprogram": "Das K1 Zentrum ONCOTYROL - Center for Personalized Cancer Medicine ist im Rahmen des vom BMWA und BMVIT initiierten Strukturprogramms COMET in Zusammenarbeit mit\r\n\r\n * Land Tirol\r\n * Land Steiermark (Abteilung 3, Abteilung 14 und Wirtschaftsressort)\r\n * Steirische Wirtschaftsförderung\r\n * den drei regionalen Universitäten und der Industrie geschaffen worden.", "organization": 14021, "category": 10, "type": 10, "partner_function": 1, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2, 416, 1040, 1154 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2208, "title": { "de": "Forschungs- und Wissenstransfer in der pflegerischen Praxis - Implementierung wissenschaftsbasierter Leitlininen", "en": "Research and knowledge transfer in nursing practice - implementation of clinical practice guidelines" }, "short": "FWT-Leitlinie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-09-01T02:00:00+02:00", "begin_effective": "2010-05-01T02:00:00+02:00", "end_planned": "2012-09-01T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2010-05-25T12:09:03+02:00", "program": null, "subprogram": null, "organization": 14509, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2099, "title": { "de": "Funktionelle MRT zur Charakterisierung der neuralen Korrelate des Multi-Tasking unter besonderer Berücksichtigung geschlechtsbezogener Unterschiede", "en": "A functional MRI study probing sex-related effects in multi tasking" }, "short": "Funktionelle MRT ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-02-01T01:00:00+01:00", "begin_effective": "2010-02-01T01:00:00+01:00", "end_planned": "2011-01-31T01:00:00+01:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2010-02-09T14:28:20+01:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 59566, "contact": 59566, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2099-59566-10" ] }, { "id": 2325, "title": { "de": "Bedeutung von MikroRNAs im Wnt Signalweg beim Gallengangskarzinom", "en": "Role of microRNAs of the wnt pathway in biliary tract cancer" }, "short": "MICRORNAS WNT PATHWAY ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-01T02:00:00+02:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2011-06-30T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2010-10-11T11:00:11+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1865, "title": { "de": "Prognostic evaluation of circulating methylated DNA using HRM assay in colorectal cancer patients", "en": "Prognostic evaluation of circulating methylated DNA using HRM assay in colorectal cancer patients" }, "short": "PROGNOSTIC EVALUATION_COLORECTAL_CANCER", "url": null, "abstract": { "de": "Beim kolorektalen Karzinom handelt es sich um einen der häufigsten malignen Tumore des Menschen. Eine operative Entfernung der Tumore in den Stadien I und II ist sehr effektiv, allerdings kommt es in 20-30% der Fälle zu Rezidiven. Daher ist es sehr wichtig, jene Patienten zu identifizieren, welche mit hoher Wahrscheinlichkeit ein Rezidiv entwickeln, und somit von einer Chemotherapie profitieren würden. Veränderte DNA Methylierung in Tumoren ist ein Kennzeichen von Krebs und wurde in kolorektalen Tumoren bereits umfassend untersucht. Eine veränderte Promotor-Methylierung kann auch in frei zirkulierenden Nukleinsäuren aus Serum detektiert werden, und stellt ein neue nicht-invasive Methode dar, um Hochrisikopatienten zu identifizieren.\r\nZiel dieses Projektes ist die Etablierung der High-Resolution Melting Real-Time PCR als prognostisches Werkzeug zur Risikoabschätzung von Wiederauftreten kolorektaler Tumoren bei Stadium II Patienten.", "en": "Beim kolorektalen Karzinom handelt es sich um einen der häufigsten malignen Tumore des Menschen. Eine operative Entfernung der Tumore in den Stadien I und II ist sehr effektiv, allerdings kommt es in 20-30% der Fälle zu Rezidiven. Daher ist es sehr wichtig, jene Patienten zu identifizieren, welche mit hoher Wahrscheinlichkeit ein Rezidiv entwickeln, und somit von einer Chemotherapie profitieren würden. Veränderte DNA Methylierung in Tumoren ist ein Kennzeichen von Krebs und wurde in kolorektalen Tumoren bereits umfassend untersucht. Eine veränderte Promotor-Methylierung kann auch in frei zirkulierenden Nukleinsäuren aus Serum detektiert werden, und stellt ein neue nicht-invasive Methode dar, um Hochrisikopatienten zu identifizieren.\r\nZiel dieses Projektes ist die Etablierung der High-Resolution Melting Real-Time PCR als prognostisches Werkzeug zur Risikoabschätzung von Wiederauftreten kolorektaler Tumoren bei Stadium II Patienten." }, "begin_planned": "2009-07-01T02:00:00+02:00", "begin_effective": "2009-07-01T02:00:00+02:00", "end_planned": "2011-06-30T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2009-07-09T15:14:13+02:00", "program": 79, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 50899, "contact": 50899, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1865-50899-10" ] }, { "id": 2641, "title": { "de": "Einfluss von Empfänger- und Spender-Cytochrom P450 3A5 Genotypen auf die Pharmakokinetik von Tacrolimus bei PatientInnen nach Lebertransplantation", "en": "Einfluss von Empfänger- und Spender-Cytochrom P450 3A5 Genotypen auf die Pharmakokinetik von Tacrolimus bei PatientInnen nach Lebertransplantation" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-01T02:00:00+02:00", "begin_effective": "2011-11-01T01:00:00+01:00", "end_planned": "2013-10-31T01:00:00+01:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2011-11-18T13:45:47+01:00", "program": null, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": 58323, "contact": 58323, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2641-58323-10" ] }, { "id": 2609, "title": { "de": "Hepcidin im Rahmen von Sepsis und Adipositas", "en": "The Role of Hepcidin in Sepsis and Obesity" }, "short": "HEPCIDIN_SEPSIS_ADIPOSITAS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2011-10-06T15:38:08+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 50778, "contact": 50778, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2609-50778-10" ] }, { "id": 2505, "title": { "de": "Assoziation von Vitamin-D-Rezeptor-Genvarianten mit der Prognose des Kolonkarzinoms", "en": "Association of vitamin D receptor gene variants with colon cancer prognosis" }, "short": "VITAMIN D RECEPTOR COLON CANCER", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-11-01T01:00:00+01:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2011-10-31T01:00:00+01:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2011-06-21T11:36:47+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 69234, "contact": 69234, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2505-69234-10", "2505-58814-12" ] }, { "id": 2985, "title": { "de": "Grazer Studie über die hormonellen Ursachen des arteriellen Bluthochdruckes (GECOH Studie)", "en": "Graz Endocrine Causes of Hypertension (GECOH) Study" }, "short": "GECOH Study", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-03-01T01:00:00+01:00", "end_planned": "2012-06-01T02:00:00+02:00", "end_effective": "2012-06-01T02:00:00+02:00", "assignment": "2012-09-24T12:56:43+02:00", "program": null, "subprogram": "Land Steiermark: Förderung wissenschaftlicher (Forschungs)Projekte", "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 53344, "contact": 53344, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2985-53344-10" ] }, { "id": 1735, "title": { "de": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 8: Lipid droplet-associated proteins regulating lipid storage and release in macrophages and foam cells", "en": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 8: Lipid droplet-associated proteins regulating lipid storage and release in macrophages and foam cells" }, "short": "GOLD3_KRATKY", "url": null, "abstract": { "de": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.", "en": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis." }, "begin_planned": "2008-12-01T01:00:00+01:00", "begin_effective": "2009-02-01T01:00:00+01:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2009-01-22T11:56:26+01:00", "program": 73, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51904, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1735-51904-10", "1735-58794-11" ] }, { "id": 2480, "title": { "de": "FET FlagShip: Information Technology Future of Medicine", "en": "FET FlagShip: Information Technology Future of Medicine" }, "short": "IT FoM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-01T02:00:00+02:00", "begin_effective": "2011-05-01T02:00:00+02:00", "end_planned": "2012-06-01T02:00:00+02:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2011-05-19T10:22:48+02:00", "program": 24, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": 51663, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": " 285609", "ethics_committee": null, "edudract_number": null, "persons": [ "2480-51663-10" ] }, { "id": 1714, "title": { "de": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling", "en": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling" }, "short": "GOLD3_BIRNER_GRUENBERGER", "url": null, "abstract": { "de": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.", "en": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis." }, "begin_planned": "2008-12-01T01:00:00+01:00", "begin_effective": "2009-02-01T01:00:00+01:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2009-01-14T12:15:11+01:00", "program": 73, "subprogram": null, "organization": 28394, "category": 10, "type": 10, "partner_function": 2, "manager": 58794, "contact": 58794, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1714-58794-10" ] }, { "id": 1822, "title": { "de": "Mechanisms of restoration of ß-cell function in relation to adipoinsular and enteroinsular axes after gastric bypass surgery in severly obese patients with type 2 diabetes - double-centre, prospective, controlled, longitudinal open study - short: Restoration of ß-cell function after gastric bypass", "en": "Mechanisms of restoration of ß-cell function in relation to adipoinsular and enteroinsular axes after gastric bypass surgery in severly obese patients with type 2 diabetes - double-centre, prospective, controlled, longitudinal open study - short: Restoration of ß-cell function after gastric bypass" }, "short": "Restoration of ß-cell function", "url": null, "abstract": { "de": "The presented project aims to: \r\n1) compare changes in â-cell function following gastric bypass in patients with short- and long-term history of type 2 diabetes (T2DM), \r\n2) evaluate the â-cell insulin response to oral and intravenous glucose load early and late after gastric bypass surgery,\r\n3) relate the early and long-term changes in â-cell function after gastric bypass to changes in parameters of adipoinsular and enteroinsular axes in patients with and without T2DM and \r\n4) compare the changes of adipoinsular and enteroinsular axes after weight loss achieved after gastric bypass with BMI-matched controls without bariatric surgery.", "en": "The presented project aims to: \r\n1) compare changes in â-cell function following gastric bypass in patients with short- and long-term history of type 2 diabetes (T2DM), \r\n2) evaluate the â-cell insulin response to oral and intravenous glucose load early and late after gastric bypass surgery,\r\n3) relate the early and long-term changes in â-cell function after gastric bypass to changes in parameters of adipoinsular and enteroinsular axes in patients with and without T2DM and \r\n4) compare the changes of adipoinsular and enteroinsular axes after weight loss achieved after gastric bypass with BMI-matched controls without bariatric surgery." }, "begin_planned": "2009-07-01T02:00:00+02:00", "begin_effective": "2009-07-01T02:00:00+02:00", "end_planned": "2011-06-30T02:00:00+02:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2009-05-18T17:08:39+02:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": 51831, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 431 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1822-51831-10" ] }, { "id": 2780, "title": { "de": "Gelotophobie - Die Angst vor dem Lachen anderer - Studie zur Erforschung der zu Grunde liegenden emotionalen Prozesse in spontaner Interaktion.", "en": "Gelotophobia - A biopsychological approach" }, "short": "Gelotophobie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-02-01T01:00:00+01:00", "begin_effective": "2012-02-01T01:00:00+01:00", "end_planned": "2012-04-30T02:00:00+02:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2012-02-06T18:26:26+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 3, "manager": 64295, "contact": 64295, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2780-64295-10" ] }, { "id": 2104, "title": { "de": "Refining the basophil activation test (BAT) for the diagnosis of Hymenoptera venom allergy", "en": "Refining the basophil activation test (BAT) for the diagnosis of Hymenoptera venom allergy" }, "short": "BAT_09", "url": null, "abstract": { "de": "Weiterentwicklung des Basophilen-Aktivierungstests (BAT) für die Diagnostik der Insektengiftallergie\r\n\r\nZur Routinediagnostik einer Insektengiftallergie gehören Anamnese, Hauttests und die Bestimmung spezifischer IgE Antikörper im Serum. Leider führen diese Verfahren manchmal zu inkonkulsiven Ergebnissen. In den letzten Jahren hat sich der Basophilenaktivierungstest (BAT) als nützliche zusätzliche Methode bewährt. Ein Nachteil des BAT ist jedoch, dass durch den Grad der Zellaktivierung im Test sich kein Rückschluss auf den Schweregrad der allergischen Reaktion ziehen lässt. Ferner sind Daten verschiedener Labors kaum vergleichbar, da es kein standardisiertes Protokoll gibt. Um nun die Möglichkeiten der Allergiediagnostik zu optimieren und für den betroffen Patienten die bestmögliche Versorgung sicherzustellen ist es unerlässlich, auf diesem Gebiet nach weiteren neuen Ansatzpunkten zu suchen. Ziel des Projektes ist es daher einen auf der Expression verschiedener neuer Oberflächenmarker basierenden Basophilenaktivierungstest für die Diagnostik der Insektengiftallergie zu entwickeln.\r\n", "en": null }, "begin_planned": "2010-05-01T02:00:00+02:00", "begin_effective": "2010-05-01T02:00:00+02:00", "end_planned": "2012-04-30T02:00:00+02:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2010-02-10T17:29:56+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 87717, "contact": 87717, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1161 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2104-87717-10" ] }, { "id": 981, "title": { "de": "SFB LIPOTOXICITY - Part 07: Myeloperoxidase-mediated lipotoxicity in the central nervous system", "en": "SFB LIPOTOXICITY" }, "short": "SFB LIPOTOXICITY", "url": null, "abstract": { "de": "Das Ziel des SFB-LIPOTOX ist die Zusammenführung relevanter Forschungsgruppen um gemeinsam ein zentrales Thema zu bearbeiten, Lipotoxizität. Unter Lipotoxizität versteht man die fehlgesteuerte Aufnahme bzw. Produktion von Fettsäuren und Lipiden, die zur Bildung (lipo)toxischer Substanzen führen, die Dysfunktion von Zellen und Geweben bewirken und im Zelltod enden können. Wir wollen jene metabolischen Vorgänge und molekularen Mechanismen untersuchen, die durch lipotoxische Effektoren ausgelöst werden und die pathologische Basis prävalenter Erkrankungen, wie z.B. dem Metabolischen Syndrom, Typ-2 Diabetes und Atherosklerose darstellen. Dieses hochgesteckte Ziel ist nur durch eine gemeinsame Anstrengung innerhalb eines dynamischen und interaktiven Konsortiums, die weit über die Möglichkeiten innerhalb von Einzelprojektförderungen hinausgeht, zu erreichen. Durch Einsatz aktueller genomischer, proteomischer und lipidomischer Methoden sollen neue lipotoxische Stoffwechselwege entdeckt werden. Durch Einsatz mutanter Maus- und Hefemodelle werden jene molekulare Mechanismen untersucht, durch die zelluläre Dysfunktion und Zelltod bewirkt werden. Die gewonnenen Erkenntnisse können somit einen wichtigen Beitrag zur Auffindung neuartiger Diagnose- und Behandlungsmethoden leisten.", "en": "Das Ziel des SFB-LIPOTOX ist die Zusammenführung relevanter Forschungsgruppen um gemeinsam ein zentrales Thema zu bearbeiten, Lipotoxizität. Unter Lipotoxizität versteht man die fehlgesteuerte Aufnahme bzw. Produktion von Fettsäuren und Lipiden, die zur Bildung (lipo)toxischer Substanzen führen, die Dysfunktion von Zellen und Geweben bewirken und im Zelltod enden können. Wir wollen jene metabolischen Vorgänge und molekularen Mechanismen untersuchen, die durch lipotoxische Effektoren ausgelöst werden und die pathologische Basis prävalenter Erkrankungen, wie z.B. dem Metabolischen Syndrom, Typ-2 Diabetes und Atherosklerose darstellen. Dieses hochgesteckte Ziel ist nur durch eine gemeinsame Anstrengung innerhalb eines dynamischen und interaktiven Konsortiums, die weit über die Möglichkeiten innerhalb von Einzelprojektförderungen hinausgeht, zu erreichen. Durch Einsatz aktueller genomischer, proteomischer und lipidomischer Methoden sollen neue lipotoxische Stoffwechselwege entdeckt werden. Durch Einsatz mutanter Maus- und Hefemodelle werden jene molekulare Mechanismen untersucht, durch die zelluläre Dysfunktion und Zelltod bewirkt werden. Die gewonnenen Erkenntnisse können somit einen wichtigen Beitrag zur Auffindung neuartiger Diagnose- und Behandlungsmethoden leisten." }, "begin_planned": "2007-03-01T01:00:00+01:00", "begin_effective": "2007-03-01T01:00:00+01:00", "end_planned": "2011-02-28T01:00:00+01:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2006-12-27T15:02:44+01:00", "program": 67, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51705, "contact": 51833, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "F30", "ethics_committee": null, "edudract_number": null, "persons": [ "981-51705-10" ] }, { "id": 2197, "title": { "de": "Aufbau eines osteuropäisches Implantationszentrum mit angeschlossenen Rehabilitations- und Trainingszentrum", "en": "Development of an Eastern European implantation center with adjacent Rehabilitation and Trainings center" }, "short": "Osteuropäisches_Implantationszentrum", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-04-01T02:00:00+02:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2011-02-01T01:00:00+01:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2010-05-07T10:52:01+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2198, "title": { "de": "Kommunikation als Screeninginstrument", "en": "Kommunikation als Screeninginstrument" }, "short": "KOMMUNIK_SCREENING", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-10-01T02:00:00+02:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2011-05-31T02:00:00+02:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2010-05-07T16:16:27+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": 54332, "contact": 54332, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 70 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2198-54332-10" ] } ] }