API @ Medical University of Graz

List projects.

Fields

`id` (`integer`)

Primary key.

Expansions

To activate relation expansion add the desired fields as a comma separated list to the expand query parameter like this:

?expand=<field>,<field>,<field>,...

The following relational fields can be expanded:

organization
category
type
partner_function
manager
contact
status
grant
research
event
study
language
program
funders

Filters

To filter for exact value matches:

?<fieldname>=<value>

Possible exact filters:

organization
category
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contact
status
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research
study
language
funders
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For advanced filtering use lookups:

?<fieldname>__<lookup>=<value>

All fields with advanced lookups can also be used for exact value matches as described above.

Possible advanced lookups:

begin_planned: gt, gte, lt, lte
begin_effective: gt, gte, lt, lte
end_planned: gt, gte, lt, lte
end_effective: gt, gte, lt, lte

GET /v1/research/project/?format=api&offset=1880&ordering=-end_effective

HTTP 200 OK
  Allow: GET, HEAD, OPTIONS
  Content-Type: application/json
  Vary: Accept
  
  {
    "count": 2265,
    "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1900&ordering=-end_effective",
    "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1860&ordering=-end_effective",
    "results": [
        {
            "id": 2023,
            "title": {
                "de": "Induction of immunological changes by endoluminal photodynamic therapy (PDT) for esophageal carcinoma",
                "en": "Induction of immunological changes by endoluminal photodynamic therapy (PDT) for esophageal carcinoma"
            },
            "short": "PDT_ESOPHAGEAL_CARCINOMA",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2009-12-18T12:29:42+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14077,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51615,
            "contact": 51615,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2023-62056-12",
                "2023-51615-10",
                "2023-51618-12"
            ]
        },
        {
            "id": 2788,
            "title": {
                "de": "Scanningbewegungen des Kopfes als Ausdruck des Schauverhaltens am gehenden Patienten im Low vision Bereich: Entwicklung der Analysemethode und Standardisierung",
                "en": "Headscanning in Mobility Testing"
            },
            "short": "Headscanning in Mobility Testing",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-05-01T02:00:00+02:00",
            "begin_effective": "2011-05-01T02:00:00+02:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2012-02-14T15:16:48+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14043,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 3,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                938
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 1329,
            "title": {
                "de": "Mapping of the bound proton fraction in the elderly brain",
                "en": "Mapping of the bound proton fraction in the elderly brain"
            },
            "short": "BOUND_PROTON_ELDERLY_BRAIN_FWF07",
            "url": null,
            "abstract": {
                "de": "The aim of this proposal is to investigate whether the bound pool fraction as a new and quantitative MR measure allows more insight into age related brain tissue changes than other quantitative MR measures. The specific aims are:\r\n\r\n*Develop a MR pulse sequence that allows to map the bound proton fraction on high field systems (>=3T) within a clinically reasonable measurement time (<15min). The sequence should offer whole brain coverage and should overcome current limitations such as the susceptibility for motion and B1 effects.\r\n\r\n*Measure the BPF in brain tissue of a large cohort of the Ausitria Stroke Prevention Study (ASPS). This gives us the opportunity to study a representative and homogeneous group of normal elderly people without a history or signs of neuropsychiatric diseases. By using a younger control cohort, we want to investigate how the BPF changes as a function of age, sex and anatonic region including cortical structures. In addition, we want to find out how the BPF varies within WMH with different severity and how it relates to the BPF in normal appearing brain tissue and to the neurocognitive performance.\r\n\r\n*Compare the sensitivity and specificity of bound proton fraction mapping to more established measures of brain tissue changes including atrophy, diffusion weighted imaging, and magnetization transfer imaging.",
                "en": "The aim of this proposal is to investigate whether the bound pool fraction as a new and quantitative MR measure allows more insight into age related brain tissue changes than other quantitative MR measures. The specific aims are:\r\n\r\n*Develop a MR pulse sequence that allows to map the bound proton fraction on high field systems (>=3T) within a clinically reasonable measurement time (<15min). The sequence should offer whole brain coverage and should overcome current limitations such as the susceptibility for motion and B1 effects.\r\n\r\n*Measure the BPF in brain tissue of a large cohort of the Ausitria Stroke Prevention Study (ASPS). This gives us the opportunity to study a representative and homogeneous group of normal elderly people without a history or signs of neuropsychiatric diseases. By using a younger control cohort, we want to investigate how the BPF changes as a function of age, sex and anatonic region including cortical structures. In addition, we want to find out how the BPF varies within WMH with different severity and how it relates to the BPF in normal appearing brain tissue and to the neurocognitive performance.\r\n\r\n*Compare the sensitivity and specificity of bound proton fraction mapping to more established measures of brain tissue changes including atrophy, diffusion weighted imaging, and magnetization transfer imaging."
            },
            "begin_planned": "2007-08-01T02:00:00+02:00",
            "begin_effective": "2008-01-01T01:00:00+01:00",
            "end_planned": "2010-07-31T02:00:00+02:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2007-07-10T14:42:36+02:00",
            "program": 72,
            "subprogram": null,
            "organization": 14051,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51279,
            "contact": 51279,
            "status": 2,
            "research": 3,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P20103",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "1329-51279-10"
            ]
        },
        {
            "id": 2092,
            "title": {
                "de": "Analysis of germline polymorphisms in the VEGF/VEGFR pathway to predict colorectal cancer outcome",
                "en": "Analysis of germline polymorphisms in the VEGF/VEGFR pathway to predict colorectal cancer outcome"
            },
            "short": "GERMLINE POLYMORPH VEGF/VEGFR",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2010-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-02-09T11:47:57+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14085,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 59304,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                894
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2092-59304-10",
                "2092-58814-12"
            ]
        },
        {
            "id": 1901,
            "title": {
                "de": "Neurale Korrelate des Schriftspracherwerbs bei morphembasiertem Training bei Legasthenie gemessen anhand der funktionellen Magnetresonanztomographie",
                "en": "Neurale Korrelate des Schriftspracherwerbs bei morphembasiertem Training bei Legasthenie gemessen anhand der funktionellen Magnetresonanztomographie"
            },
            "short": "Legasthenie ",
            "url": null,
            "abstract": {
                "de": "Die Lese- und Rechtschreibschwäche (Legasthenie) wird zunehmend als ernstzunehmendes Problem erkannt. Erscheinungsformen und Ursachen sind vielfältig und weitgehend ungeklärt. Die zum überwiegenden Teil durchschnittlich bis überdurchschnittlich intelligenten Kinder und Jugendlichen haben-teils organisch, teils psychosozial bedingt- spezifische Schwierigkeiten beim Lesen und Schreiben, wobei die Leistungen \"...unter dem Niveau liegen, das aufgrund des Alters, der allgemeinen Intelligenz und der Beschulung zu erwarten ist\" (Dilling et al. 1991). Wird die Lese-Rechtschreibschwäche nicht frühzeitig erkannt und behandelt, wirkt sich diese bald auch in anderen Wissensbereichen, in denen Lesen vorausgesetzt wird, negativ aus.\r\nIn dieser Studie sollen legasthene Kinder und Jugendliche zwischen 9 und 16 Jahren untersucht und behandelt werden. In einem Vortest wird untersucht, mit welchen psychologischen Funktionsstörungen die Lese- und Rechtschreibschwäche einhergeht. Die TeilnehmerInnen werden dann einer speziellen fMRT Untersuchung unterzogen. Anschließend wird die Gruppe nach einem 5-wöchigen Intensivtraining (mittels MORPHEUS: einem in der Steiermark entwickelten computergestützten Grundwortschatz-Segmentierungstraining, das auf jeden beliebigen Heim-PC installiert werden kann) erneut einer fMRT Untersuchung zugeführt. Eine zweite Warte- bzw. Kontrollgruppe erhält zunächst kein Rechtschreibtraining, wird aber ebenso zweimalig mittels fMRT untersucht. Dadurch lassen sich wesentliche Erkenntnisse über neurophysiologische Veränderungen als Folge des Trainings erwarten.",
                "en": "Die Lese- und Rechtschreibschwäche (Legasthenie) wird zunehmend als ernstzunehmendes Problem erkannt. Erscheinungsformen und Ursachen sind vielfältig und weitgehend ungeklärt. Die zum überwiegenden Teil durchschnittlich bis überdurchschnittlich intelligenten Kinder und Jugendlichen haben-teils organisch, teils psychosozial bedingt- spezifische Schwierigkeiten beim Lesen und Schreiben, wobei die Leistungen \"...unter dem Niveau liegen, das aufgrund des Alters, der allgemeinen Intelligenz und der Beschulung zu erwarten ist\" (Dilling et al. 1991). Wird die Lese-Rechtschreibschwäche nicht frühzeitig erkannt und behandelt, wirkt sich diese bald auch in anderen Wissensbereichen, in denen Lesen vorausgesetzt wird, negativ aus.\r\nIn dieser Studie sollen legasthene Kinder und Jugendliche zwischen 9 und 16 Jahren untersucht und behandelt werden. In einem Vortest wird untersucht, mit welchen psychologischen Funktionsstörungen die Lese- und Rechtschreibschwäche einhergeht. Die TeilnehmerInnen werden dann einer speziellen fMRT Untersuchung unterzogen. Anschließend wird die Gruppe nach einem 5-wöchigen Intensivtraining (mittels MORPHEUS: einem in der Steiermark entwickelten computergestützten Grundwortschatz-Segmentierungstraining, das auf jeden beliebigen Heim-PC installiert werden kann) erneut einer fMRT Untersuchung zugeführt. Eine zweite Warte- bzw. Kontrollgruppe erhält zunächst kein Rechtschreibtraining, wird aber ebenso zweimalig mittels fMRT untersucht. Dadurch lassen sich wesentliche Erkenntnisse über neurophysiologische Veränderungen als Folge des Trainings erwarten."
            },
            "begin_planned": "2009-09-01T02:00:00+02:00",
            "begin_effective": "2009-09-01T02:00:00+02:00",
            "end_planned": "2011-08-31T02:00:00+02:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2009-08-26T15:51:25+02:00",
            "program": null,
            "subprogram": "Land Steiermark. Projektantrag über 5.000,- euro",
            "organization": 14051,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50173,
            "contact": 50173,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "1901-50173-10"
            ]
        },
        {
            "id": 2031,
            "title": {
                "de": "Genetic variants in the RAD51, BRCA1 and BRCA2 genes as predictors of radiation response and toxicity in prostate cancer patients",
                "en": "Genetic variants in the RAD51, BRCA1 and BRCA2 genes as predictors of radiation response and toxicity in prostate cancer patients"
            },
            "short": "GENETIC_PROSTATE_CANCER_OeNB",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-01-11T15:12:11+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14060,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50495,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2031-50495-10",
                "2031-50910-12"
            ]
        },
        {
            "id": 1610,
            "title": {
                "de": "Vitamin D and new bone marker levels in breast cancer patients with and without bone metastases",
                "en": "Vitamin D and new bone marker levels in breast cancer patients with and without bone metastases"
            },
            "short": "VIT_D_BONE_MARKER_LEVELS",
            "url": null,
            "abstract": {
                "de": "Brustkrebs (BrCa) ist die häufigste Form von Krebs bei Frauen. Das Skelettsystem ist ein bevorzugtes Ziel für Metastasen bei BrCa. Hoher Knochenumsatz erhöht das Risiko für Krankheitsprogression und Tod. Der im Knochenstoffwechsel etablierte Einfluss von Vitamin D3 könnte daher auch ein wichtiger Risikofaktor für Skelettmetastasen sein.\r\nVitamin D3 und Serummarker des Knochenstoffwechsels sollen aus einer großen retrospektiven Kohorte von BrCa-Patientinnen mit einem Pool von 5400 BrCa-Patientinnen an ausgewählten Patientinnen mit (n=1050) und ohne Knochenmetastasen in konsekutiven Serumproben ausgewertet werden. Diese Gruppen werden in Alter und Tumorstadium übereingestimmt und sowohl im Querschnitt als auch im Verlauf nach Knochenmetastasen untersucht. Wir erwarten aus dieser Auswertung neue Perspektiven für Vitamin D3 und Knochenstoffwechselmarker in Pathophysiologie, Diagnose und Verlauf von Knochenmetastasen bei Brustkrebspatientinnen.",
                "en": "Brustkrebs (BrCa) ist die häufigste Form von Krebs bei Frauen. Das Skelettsystem ist ein bevorzugtes Ziel für Metastasen bei BrCa. Hoher Knochenumsatz erhöht das Risiko für Krankheitsprogression und Tod. Der im Knochenstoffwechsel etablierte Einfluss von Vitamin D3 könnte daher auch ein wichtiger Risikofaktor für Skelettmetastasen sein.\r\nVitamin D3 und Serummarker des Knochenstoffwechsels sollen aus einer großen retrospektiven Kohorte von BrCa-Patientinnen mit einem Pool von 5400 BrCa-Patientinnen an ausgewählten Patientinnen mit (n=1050) und ohne Knochenmetastasen in konsekutiven Serumproben ausgewertet werden. Diese Gruppen werden in Alter und Tumorstadium übereingestimmt und sowohl im Querschnitt als auch im Verlauf nach Knochenmetastasen untersucht. Wir erwarten aus dieser Auswertung neue Perspektiven für Vitamin D3 und Knochenstoffwechselmarker in Pathophysiologie, Diagnose und Verlauf von Knochenmetastasen bei Brustkrebspatientinnen."
            },
            "begin_planned": "2008-07-01T02:00:00+02:00",
            "begin_effective": "2008-07-01T02:00:00+02:00",
            "end_planned": "2009-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2008-08-22T12:07:22+02:00",
            "program": 79,
            "subprogram": null,
            "organization": 14080,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51809,
            "contact": 51809,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "1610-51809-10",
                "1610-51692-12",
                "1610-57544-12"
            ]
        },
        {
            "id": 2097,
            "title": {
                "de": "Role of SPN in PP1-mediated RyR2 regulation and intracellular Ca2+ handling",
                "en": "Role of SPN in PP1-mediated RyR2 regulation and intracellular Ca2+ handling"
            },
            "short": "ROLE OF SPN ",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-02-09T12:56:38+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                894
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2130,
            "title": {
                "de": "Kinder erzählen: Text- und Erzählkompetenz im Vorschulalter: eine Voraussetzung für den schulischen Erfolg.",
                "en": "Narratives in first language acquisition."
            },
            "short": "TEXT- UND ERZÄHLKOMPETENZ",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-03-01T01:00:00+01:00",
            "begin_effective": "2010-03-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-02-24T10:55:39+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 58883,
            "contact": 58883,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2130-58883-10"
            ]
        },
        {
            "id": 1002,
            "title": {
                "de": "EuroSTEC: Soft tissue engineering for congenital birth defects in children: from \"biomatrix - cell interaction - model system\" to clinical trials",
                "en": "EuroSTEC: Soft tissue engineering for congenital birth defects in children: from \"biomatrix - cell interaction - model system\" to clinical trials"
            },
            "short": "EuroSTEC",
            "url": null,
            "abstract": {
                "de": "The aim of this project is to use modern tissue engineering approaches to treat children with structural disorders present at birth, such as spina bifida, urogenital defects or abdominal wall defects and surrounding anomalies. The project strives to elucidate underlying mechanisms and take a translational route through in vitro and animal experiments.\r\nThis project will give more insight in the opportunities for advanced technical possibilities with tissue engineering techniques and new treatment strategies for severe and major structural congenital birth defects in children. \r\n",
                "en": "The aim of this project is to use modern tissue engineering approaches to treat children with structural disorders present at birth, such as spina bifida, urogenital defects or abdominal wall defects and surrounding anomalies. The project strives to elucidate underlying mechanisms and take a translational route through in vitro and animal experiments.\r\nThis project will give more insight in the opportunities for advanced technical possibilities with tissue engineering techniques and new treatment strategies for severe and major structural congenital birth defects in children. \r\n"
            },
            "begin_planned": "2006-11-01T01:00:00+01:00",
            "begin_effective": "2007-01-01T01:00:00+01:00",
            "end_planned": "2011-10-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2007-01-15T14:22:41+01:00",
            "program": 21,
            "subprogram": null,
            "organization": 14049,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2093,
            "title": {
                "de": "Isolation of Side Population Cells in Human Soft Tissue Sarcomas",
                "en": "Isolation of Side Population Cells in Human Soft Tissue Sarcomas"
            },
            "short": "ISOLATION OF SIDE POP CELLS ",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-02-09T12:52:51+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14052,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50696,
            "contact": 50696,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                894
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2093-50696-10"
            ]
        },
        {
            "id": 2095,
            "title": {
                "de": "Purkinje Topology",
                "en": "Purkinje Topology"
            },
            "short": "PURKINJE TOPOLOGY",
            "url": null,
            "abstract": {
                "de": "Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. ",
                "en": "Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. "
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-02-09T12:53:47+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50967,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                894
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2095-50967-10"
            ]
        },
        {
            "id": 2341,
            "title": {
                "de": "Einzelzellanalyse in der forensischen Medizin",
                "en": "Single cell analysis in forensic medicine"
            },
            "short": "Single cell analysis",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-05-01T02:00:00+02:00",
            "begin_effective": "2010-12-01T01:00:00+01:00",
            "end_planned": "2011-04-30T02:00:00+02:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-11-17T11:21:30+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14017,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 54171,
            "contact": 54171,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2341-54171-10"
            ]
        },
        {
            "id": 2043,
            "title": {
                "de": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action",
                "en": "Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action"
            },
            "short": "ORPHAN RECEPTOR GPR55",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-01-20T12:45:29+01:00",
            "program": 92,
            "subprogram": null,
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                20
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2550,
            "title": {
                "de": "Endothelin und Matrixmetalloproteinasen im ersten Schwangerschaftstrimester",
                "en": "Endothelin and matrix metalloproteinases in the first trimester of pregnancy"
            },
            "short": "EndothelMatrix",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-08-01T02:00:00+02:00",
            "begin_effective": "2011-08-01T02:00:00+02:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2011-08-02T14:12:12+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14038,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2090,
            "title": {
                "de": "Expression profiling in hypoxic non-small cell lung cancer",
                "en": "Expression profiling in hypoxic non-small cell lung cancer"
            },
            "short": "NON-SMALL CELL LUNG CANCER ",
            "url": null,
            "abstract": {
                "de": "Das Bronchialkarzinom ist nach wie vor die führende Krebstodesursache weltweit. 80% sind sogenannte Nicht-kleinzellige Bronchialkarzinome (non-small cell lung cancers, NSCLC). Das Gesamtüberleben der Patienten mit NSCLC ist schlecht, trotz der derzeit vorhandenen Therapieoptionen, zum Teil wegen Resistenz gegenüber Radio- und Chemotherapie. Tumorhypoxie (verminderte Sauerstoffzufuhr im Tumor) induziert in den Tumorzellen Adaptationsvorgänge und ist zum Teil für die Therapieresistenz verantwortlich. Die genauen Mechanismen sind jedoch nicht bekannt. Unser neu etabliertes ex-vivo Modell der hypoxischen Adaptation beim NSCLC, welches auf der Verwendung von kleinsten NSCLC Fragmenten aus Operationsmaterial beruht, ist geignet, um die Vorgänge im Tumor unter hypoxischen Bedingungen zu untersuchen. Das Ziel der vorliegenden Studie ist, die Genexpressionsmuster der in Hypoxie bzw unter normalen Sauerstoffbedingungen kultivierten NSCLC Fragmente zu vergleichen. Die differenziell regulierten Gene werden dafür mittels cDNA microarrays bestimmt. Die Ergebnisse werden in nachfolgenden Einzelgen-Polymerase Kettenreaktionen validiert. Unsere Studie könnte somit das Verständnis der Pathomechanismen beim Tumorwachstum verbessern und mögliche neue Therapieoptionen beim NSCLC aufzeigen.",
                "en": "Lung cancer is the leading cause of cancer deaths overall in the world. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancers. Overall survival is poor, in part due to resistance to chemotherapy and radiotherapy. Intratumoral hypoxia (limited oxygen supply) frequently occurs in solid tumors, such as NSCLC. Hypoxia initiates adaptive responses in tumor cells and was shown to induce chemotherapy resistance and promote aggressive tumor growth. The mechanisms of hypoxia-induced adaptive responses in solid tumors are not fully elucidated, yet. We established an ex-vivo model for hypoxic adaptation using NSCLC surgery fragments. The fragments are maintained in short-time culture in hypoxia or ambient oxygen (normoxia) without significant loss of viability or increase in apoptosis and display significant induction of carbonic anhydrase IX, a marker for tumor hypoxia, under hypoxic conditions. The aim of the current study is to analyze hypoxia-induced gene expression changes using cDNA microarrays and consecutive single gene real-time polymerase chain reaction (RT-PCR) on hypoxic vs. normoxic NSCLC fragments, in order to identify genes that are consistently induced or suppressed in hypoxia.  Our study thus provides a novel approach to identify molecular pathways that are crucial for hypoxic adaptive changes in NSCLC and might represent targets for therapy."
            },
            "begin_planned": "2010-01-01T01:00:00+01:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2011-12-31T01:00:00+01:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-02-09T11:39:13+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14087,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 57557,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                894
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2090-57557-10"
            ]
        },
        {
            "id": 1510,
            "title": {
                "de": "EuroSTEC: Soft tissue engineering for congenital birth defects in children: from \"biomatrix - cell interaction - model system\" to clinical trials",
                "en": "EuroSTEC: Soft tissue engineering for congenital birth defects in children: from \"biomatrix - cell interaction - model system\" to clinical trials"
            },
            "short": "IMPPACT",
            "url": null,
            "abstract": {
                "de": "IMPPACT will develop an intervention planning and monitoring application for Radiofrequency Ablation (RFA) of malignant liver tumours. RFA is a minimally invasive form to treat cancer without open surgery, by placing a needle inside the malignancy and destroying it through intensive heating. Though the advantages of this approach ale obvious, the intervention is currently hard to plan, almost impossible to monitor or assess, and therefore is not the first choice for treatment. IMPPACT will develop a physiological model of the liver and simulate the intervention's result, accounting for patient specific physiological factors. Gaps in the understanding of particular aspects of the RFA treatment will be closed by multi-scale studies on cells and animals. New findings will be evaluated microscopically and transformed into macroscopic equations. The long-established bio-heat equation will be extended to incorporate multiple scales. Validation will be performed at multiple levels. Images from ongoing patient treatment will be used to cross check validity for human physiology. Final validation will be performed at macroscopic level through visual comparison of simulation and treatment results gathered in animal studies and during patient treatment. This extensive validation together with a user-centered software design approach will guarantee suitability of the solution for clinical practice. The consortium consists of two Hospitals, three Universities, one Research Institute and one industrial SME. The final project deliverables will be the patient specific intervention planning system and an augmented reality training simulator for the RFA intervention.",
                "en": "IMPPACT will develop an intervention planning and monitoring application for Radiofrequency Ablation (RFA) of malignant liver tumours. RFA is a minimally invasive form to treat cancer without open surgery, by placing a needle inside the malignancy and destroying it through intensive heating. Though the advantages of this approach ale obvious, the intervention is currently hard to plan, almost impossible to monitor or assess, and therefore is not the first choice for treatment. IMPPACT will develop a physiological model of the liver and simulate the intervention's result, accounting for patient specific physiological factors. Gaps in the understanding of particular aspects of the RFA treatment will be closed by multi-scale studies on cells and animals. New findings will be evaluated microscopically and transformed into macroscopic equations. The long-established bio-heat equation will be extended to incorporate multiple scales. Validation will be performed at multiple levels. Images from ongoing patient treatment will be used to cross check validity for human physiology. Final validation will be performed at macroscopic level through visual comparison of simulation and treatment results gathered in animal studies and during patient treatment. This extensive validation together with a user-centered software design approach will guarantee suitability of the solution for clinical practice. The consortium consists of two Hospitals, three Universities, one Research Institute and one industrial SME. The final project deliverables will be the patient specific intervention planning system and an augmented reality training simulator for the RFA intervention."
            },
            "begin_planned": "2008-06-01T02:00:00+02:00",
            "begin_effective": "2008-09-01T02:00:00+02:00",
            "end_planned": "2011-05-31T02:00:00+02:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2008-04-09T17:00:52+02:00",
            "program": 24,
            "subprogram": null,
            "organization": 14073,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 50874,
            "contact": 50874,
            "status": 2,
            "research": 3,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "1510-50874-10",
                "1510-62118-12",
                "1510-51955-12",
                "1510-51983-12"
            ]
        },
        {
            "id": 2033,
            "title": {
                "de": "Mit autologen Thrombozyten angereichertes körpereigenes Fibrin zur Förderung der Wundheilung bei chronischem Ulcus cruris venosum (kontrollierte prospektive randomisierte klinische Studie)",
                "en": "Mit autologen Thrombozyten angereichertes körpereigenes Fibrin zur Förderung der Wundheilung bei chronischem Ulcus cruris venosum (kontrollierte prospektive randomisierte klinische Studie)"
            },
            "short": " Ulcus cruris venosum Studie",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2008-10-01T02:00:00+02:00",
            "begin_effective": "2010-01-01T01:00:00+01:00",
            "end_planned": "2009-09-30T02:00:00+02:00",
            "end_effective": "2011-12-31T01:00:00+01:00",
            "assignment": "2010-01-12T17:36:20+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14073,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51612,
            "contact": 51612,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "2033-51612-10"
            ]
        },
        {
            "id": 2406,
            "title": {
                "de": "Adipokine Visfatin und Chemerin im Kindes- und Jugendalter",
                "en": "The adipokines visfatin and chemerin in childhood and adolescence"
            },
            "short": "ADIPOKINE VISFATIN CHEMERIN",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2010-10-01T02:00:00+02:00",
            "begin_effective": "2011-03-01T01:00:00+01:00",
            "end_planned": "2011-10-01T02:00:00+02:00",
            "end_effective": "2011-12-30T01:00:00+01:00",
            "assignment": "2011-02-15T12:46:08+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14091,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 2460,
            "title": {
                "de": "Etablierung organtypischer Zellkultur für Herzgewebe",
                "en": "Establishing of organotypic cell culture for heart tissue"
            },
            "short": "ORGANOTYPIC CELL CULTURE HEART TISSUE",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2011-03-01T01:00:00+01:00",
            "begin_effective": "2011-05-01T02:00:00+02:00",
            "end_planned": "2011-08-31T02:00:00+02:00",
            "end_effective": "2011-12-30T01:00:00+01:00",
            "assignment": "2011-04-07T13:19:02+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14073,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        }
    ]
}

Project List

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